Medication dispenser depilling mechanism

Abstract

The present invention provides a depilling device for a blister package comprising at least one array of dosage forms to be dispensed, wherein each dosage form is contained within a blister formed as a covered cavity bounded by a backing, said device comprising a double action depilling mechanism, comprising a first pusher, sized and adapted to engage a top surface of said covered cavity and to exert a first sufficient force thereagainst so as to push said dosage form contained therein against its respective bounding backing, and a second pusher sized and adapted to more forcibly engage said top surface of said covered cavity and to exert a second sufficient force thereagainst so as to expel said dosage form from said blister.

Claims

1. A depilling device for a blister package comprising at least one dosage form to be dispensed, wherein: said at least one dosage form is contained within a blister formed as a covered cavity bounded by a backing; and said device comprises a double action depilling mechanism, comprising: a first pusher, sized and adapted to engage a top surface of said covered cavity and to exert a first sufficient force thereagainst so as to push said dosage form contained therein against its respective backing; and a second pusher sized and adapted to more forcibly engage said top surface of said covered cavity and to exert a second sufficient force thereagainst so as to expel said dosage form from said blister, wherein said first pusher, said second pusher or a combination thereof is operationally connected to a release means that promotes said first sufficient force, said second sufficient force or a combination thereof, resulting in release of said dosage form from said blister.

2. A depilling device according to claim 1 wherein said depilling device is adapted for depilling of an array of dosage forms to be dispensed, optionally wherein each dosage form is contained within a blister formed as a covered cavity bounded by a backing.

3. A depilling device according to claim 1 wherein said second sufficient force is of greater magnitude than said first sufficient force.

4. A depilling device according to claim 1 wherein said backing is flexible or penetrable.

5. A depilling device according to claim 1 wherein said backing is a foil backing.

6. A depilling device according to claim 1 wherein said backing is formed from a combination of a foil backing and a reinforcing film layer.

7. A depilling device according to claim 1, for a standard blister package of the type having at least one array of dosage forms to be dispensed, wherein said blister is a polymeric blister said backing is a foil backing, and said first pusher is sized and adapted to engage said top surface to exert said first sufficient force thereagainst so as to push said dosage form against its respective backing until rupture thereof, and said second pusher is sized and adapted to more forcibly engage said top surface and any dosage form at least partially retained within said blister by said ruptured backing and to force the complete release of said dosage form from said blister through said ruptured backing.

8. A depilling device according to claim 1, for a standard blister package of the type having at least one array of dosage forms to be dispensed, wherein said blister is a polymeric blister and said backing is a combination foil and polymer film backing, and said first pusher is sized and adapted to engage said top surface to exert said first sufficient force thereagainst so as to push said at least one dosage form against its respective backing, and said second pusher is sized and adapted to more forcibly engage said top surface and any dosage form at least partially retained within said blister by said backing and to force the complete release of said dosage form from said blister through said combination foil and polymer film backing.

9. A depilliing device according to claim 1 where said depilling mechanism is manually operated.

10. A depilliing device according to claim 1 where said depilling mechanism is motor driven, optionally where said depilling mechanism is driven by a single motor.

11. A depilling device according to claim 1 wherein said second pusher is spring loaded and capable of a hammer action when released and wherein said second pusher applies said hammer action on said top surface of said covered cavity containing at least one dosage form of said blister and wherein said hammer action promotes full release of said dosage form from said blister, facilitated by prior pressure or partial release promoted by the exertion of force thereagainst by said first pusher.

12. A depilling device according to claim 1 wherein engagement of said first pusher exerts a first force on said top surface which is operationally connected to spring loading of said second pusher.

13. A depilling device according to claim 1 provided in conjunction with a stationary depilling station for the controlled sequential delivery of a regimen of dosage forms on an as-needed basis, from any standard commercial flat multiple dosage form-containing pack of the double arrayed blister package type having two columns and a plurality of rows of dosage forms to be dispensed from said blisters, which are each formed as a covered cavity with a backing, said station comprising a blister pack support having two spaced-apart dosage form receiving apertures, each aperture being sized and positioned to receive dosage forms of same or different sizes, shapes and spacing in said blister pack array; wherein said depilling device comprises a pair of said double action depilling mechanisms positioned, upon activation, to force at least one dosage form at a time from its respective blister through the backing of said blister via one of said apertures as said blister pack is advanced through said stationary depilling station, each of said pair being motor driven.

14. A depilling device according to claim 1 wherein said release means are in the forms of a reciprocating shafts, which are reciprocally movable along parallel axes.

15. A depilling device according to claim 1 provided in conjunction with a depilling station for the controlled sequential delivery of a regimen of dosage forms, from a circular blister package type having at least one single circular array of dosage forms to be dispensed from said blister.

16. A depilling device according to claim 1 provided in conjunction with a depilling station for the controlled sequential delivery of a regimen of dosage forms, from a circular blister package type having at least one single circular array of dosage forms to be dispensed from said blister, said device sized to be mobile and fit into a hand bag or pocket.

17. A depilling device according to claim 1 provided in conjunction with a depilling station for the controlled sequential delivery of a regimen of dosage forms, from a circular blister package type having at least one single circular array of dosage forms to be dispensed from said blister, said device sized having an outlet to deliver the at least one dosage form into a container.

18. A depilling device according to claim 1 provided in conjunction with a depilling station for the controlled sequential delivery of a regimen of dosage forms, from a circular blister package type having at least one single circular array of dosage forms to be dispensed from said blister, said device sized having an outlet to deliver the at least one dosage form directly into a mouth.

19. A depilling device for a blister package comprising at least one dosage form to be dispensed, wherein: said at least one dosage form is contained within a blister formed as a covered cavity bounded by a backing; and said device comprises a double action depilling mechanism, comprising: a first pusher, sized and adapted to engage a top surface of said covered cavity and to exert a first sufficient force thereagainst so as to push said dosage form contained therein against its respective bounding backing; and a second pusher sized and adapted to more forcibly engage said top surface of said covered cavity and to exert a second sufficient force thereagainst so as to expel said dosage form from said blister, wherein said first pusher and said second pusher are concentrically configured with said second pusher being reciprocally movable within a tubular opening provided in said first pusher.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIGS. 1A and 1B show embodied elements of embodied depilling devices of this invention in cross-section. The First pusher 11 is sized and adapted to engage a top surface 16 of a covered cavity 15 and to exert a first sufficient force thereagainst. The second pusher 12 sized and adapted to more forcibly engage the top surface of said covered cavity and to exert a second sufficient force thereagainst is depicted. The direction 18 of applied force of the first pusher 11 and the direction 17 of the second pusher 12 is shown. The blister package 13 orientation to position the first and second pusher proximally to the blister containing a unit dosage form is evident. A blister pack with a single pill (1A) or a single column array of pills (1B) is shown.

(2) FIG. 1C shows elements of another embodied depilling device of this invention in cross-section, where the device is sized and adapted to release unit dosage forms from a circular array 19 blister pack containing same.

(3) FIG. 1D shows elements of another embodied depilling device of this invention in cross-section, where the blister is arranged such that the pushers are oriented to apply force horizontally, as opposed to vertically in order to release the dosage form contained therein.

(4) FIG. 2 shows a cross section of an embodied blister pack 13 containing a covered cavity 22 in which a unit dosage 15 is contained. The blister is bounded by a single layer backing 24, such as a foil backing.

(5) FIG. 3 shows a cross section of an embodied blister pack 21 containing a covered cavity 22 in which a unit dosage 15 is contained. The blister is bounded by a double layer backing, having a first layer 24, which for example is a foil backing; and a second layer 31, which is a strengthening layer, for example, a polymer film.

(6) FIG. 4 shows a cross sectional view of embodied elements of an embodied depilling device 10 of this invention in cross-section, detailing engagement of a first pusher 11 with the top surface of a covered cavity to exert a first sufficient force which deforms the dome structure 42. As a result of this first applied force, a rupture 41 in the bounding backing 24 is created, which promotes partial egress of the unit dosage form 43 contained therein.

(7) FIG. 5a shows a cross sectional view of embodied elements of an embodied depilling device 10 of this invention in cross-section, detailing engagement of a first pusher 11 with the top surface of a covered cavity to exert a first sufficient force which places the dome structure 42 under tension. The direction of applied force is shown 51. The unit dosage form 54 is located in a blister pack with a strengthened backing 55 of two layers a proximal layer 55 and distal layer 59. Positioning of the second pusher 12 with respect to the first pusher 11 is shown, as well.

(8) FIG. 5b shows a cross sectional view of the embodied depilling device in FIG. 5a, detailing further engagement of the proximal end 57 of the second pusher 12 with the top surface of the covered cavity under pressure 42, further deforming the surface. The unit dosage form 54 in turn, is now completely released from the tensioned backing 55.

(9) FIG. 6a shows a cross section of a reciprocating crank shaft 61 and a linking shaft 62, which facilitates the first pusher 11 engaging the blister pack. The arrangement promotes alternation between a pressurized and relaxed state, as the reciprocating crank shaft is revolved around the indicated axis in the direction of movement indicated by 63.

(10) FIG. 6b shows a cross section of a reciprocating crank shaft 61 and a linking shaft 62, showing 180 degree view of that shown in FIG. 61. The reciprocating crank shaft 61 has a tensioner part 66, which is engaged by a latching part 67 of the shaft 65 of the second pusher 12. When the reciprocating crank shaft 61 is rotated about the axis in the direction as shown in 69, for at least half of the revolution length of the crank shaft, the tensioner is latched via the latching part 67, which in turn causes tensioning of the spring 68, which is positioned over the shaft 58 of the second pusher 12, between the tamper 57 and the stabilizer pin 64.

(11) FIG. 7 shows a similar cross-sectional view to that shown in FIG. 6b, however, in this aspect, when the reciprocating crank shaft 61 is further rotated about the axis in the direction as shown in 69, from that shown in FIG. 6b, for at least the second half of the revolution length of the crank shaft, the tensioner is no longer latched via the latching part 67, which in turn causes relaxation/release of the spring 68, as the shaft 58 of the second pusher 12 is propelled downward, until the latching part 67 abuts the stabilizer pin 64.

(12) FIG. 8 shows a side perspective view of the depilling device depicted in FIG. 6b, rotated 90 degrees from that shown in FIG. 6b, illustrating the potential for attachment of a manually operated device. In this aspect, a rotating gear 75 engages a reciprocating geared lever 78, which is activated by, for example, a push switch 82 or any other appropriate structure to actuate the reciprocating crank shaft and tensioner mechanism;

(13) FIG. 9 shows a side perspective view of the depilling device depicted in FIG. 6b, rotated 90 degrees from that shown in FIG. 6b, illustrating the potential for attachment of a motor 80 to the reciprocating crank shaft 61;

(14) FIG. 10 shows a depilling device comprising two depilling stations 90 and 91, respectively, and their relative positioning with respect to a blister pack 94 containing two columns 92 of spaced unit dosage forms and the relative positioning of dosage form receiving apertures 93 through which the released unit dosage form is ejected.

(15) FIG. 11 shows positioning of the depilling device shown in FIG. 9, as positioned over a circular blister pack array 102.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

(16) This invention provides a depilling device for a blister package, which can accommodate a single pill or one or more arrays of dosage forms to be dispensed, with each dosage form being contained within a blister formed as a covered cavity bounded by a backing. Unique aspects of the depilling device include the presence of a double action depilling mechanism, comprising a first pusher, sized and adapted to engage a top surface of a covered cavity of the blister pack and to exert a first sufficient force thereagainst so as to push a dosage form contained therein against its respective bounding backing, and a second pusher sized and adapted to more forcibly engage the top surface of the covered cavity and to exert a second sufficient force thereagainst so as to expel the dosage form from the blister.

(17) Referring now to FIGS. 1A and 1B, in which embodied elements of a depilling device of the invention is shown, a blister pack 13 with a single dosage form or single column array of unit dosage forms arranged are depicted, where the unit dosage forms are contained in a respective cavity 15 with a covered region 16. The depilling device engages the blister package in the direction marked by element 18 in the figure. The depilling device comprises a first pusher, depicted in the figure as element 11, and a second pusher, depicted in the figure as element 12, where there structural arrangement is coupled to promote first engagement by the first pusher followed by second engagement of the covered cavity by the second pusher.

(18) In this aspect, the second pusher is comprised of at least two parts, an elongated shaft 58 and a striker element 57.

(19) It will be appreciated that the depiction is for exemplification purposes and other geometries of the first and second pusher are readily envisioned.

(20) Referring now to FIG. 1C, in which embodied elements of a depilling device of the invention is shown, a blister pack 13 with a single array of unit dosage forms arranged in a circular pattern is depicted and each dosage forms is contained in a respective cavity 15 with a covered region 16. Other elements of the depilling device are comparable to counterpart elements depicted in FIG. 1A, 1B.

(21) FIG. 1D shows elements of another embodied depilling device of this invention in cross-section, where the blister is arranged such that the pushers are oriented to apply force horizontally, as opposed to vertically in order to release the dosage form contained therein. Other elements of the depilling device are comparable to counterpart elements depicted in FIG. 1A, 1B and it will be apparent to the skilled artisan that the depilling devices of this invention may comprise rotation of various elements in order to accommodate different sized, shaped blister packs, or in some embodiments, different orientations of such blister packs therein, all of which are to be considered as part of this invention.

(22) It will be appreciated that numerous blister packages are available commercially and a feature of the devices and methods of this invention is their suitability for application using readily available blister packages and dosage forms already packaged therein.

(23) In some aspects, the elements of the depilling device may be comprised of any appropriate material, such as metals or metal alloys or metal composites, polymers, plastics, resins, and others. In some aspects, mixtures of elements may be readily used for the construction of any of the stated parts of the device or parts of the specified elements in the device. For example, and in one embodiment, with respect to the second pusher of this invention, the shaft element 58 and striker element 57 may be comprised of the same or different materials. In some aspects, the striker element 57 may be comprised of a material with significantly greater hardness than the shaft, or vice versa. In some aspects, the striker element may be comprised of a plastic, whereas the shaft may be comprised of a metal part, or vice versa.

(24) The invention is not to be limited in terms of the composition of the elements of the pushers as described herein.

(25) FIGS. 2 and 3 depict embodiments of blister packages, highlighting the nature of the backing of same, whereby depilling the unit dosage form located therein can be readily accomplished in a controlled manner via the devices and methods of this invention.

(26) In FIG. 2, a unit dosage form 15 is located in a blister package 13, inside the covered cavity 22, which is bounded by a single layer backing 24.

(27) In some aspects, the single layer backing will be any conventional backing, such as a thin foil, thin paper or other appropriate backing.

(28) In FIG. 3, a unit dosage form 15 is located in a blister package 21, inside the covered cavity 22, which is bounded by a multi-layer backing. In some aspects, the multi-layer backing is comprised of 2 layers, an inner layer 24 and an outer layer 31, so termed based on their relative positioning with respect to the outer packaging surface.

(29) In some aspects, the inner layer may be comprised of the same materials as the single layer as depicted in FIG. 2. In some aspects, the inner layer may be thinner or comprise a coating on the outer layer.

(30) In some aspects, the backing, whether in single layer, multi-layer or both, is flexible or penetrable. In some aspects, the backing is a foil backing and in some embodiments, the backing is formed from a combination of a foil backing and a reinforcing film layer.

(31) In some aspects, the blister packages for use with the devices and methods of this invention could contain one or more unit dosage forms therein, and same can comprise any suitable form, such as a tablet, capsule, caplet, suppository, pessary, gelcap and others, as will be appreciated by the skilled artisan.

(32) It is to be understood that while a specific blister in a blister pack normally and preferably contains only one dosage form to be dispensed, it is possible to prepare blister packs with more than one dosage form and/or more than one type of dosage form per blister when a regimen of providing two or more dosage forms simultaneously is prescribed.

(33) It is to be understood that the invention contemplates a single blister pack being dispensed containing one or more dosage forms within the single blister pack, or in other embodiments, a single column array of blisters, with each blister containing one or more dosage forms in each blister, or in some embodiments, a single array of blisters in other patterns, for example, a circular array of blisters, with each blister containing one or more dosage forms in each blister, or in some embodiments, an array of two or more columns, or two or more rows, or a combination thereof, of blisters, with each blister containing one or more dosage forms in each blister, and other arrays, as will be appreciated by the skilled artisan. The invention is not to be limited in terms of the arrays that may be introduced, or the number of dosage forms included in each blister of the arrays suitable for use with the depilling devices of this invention.

(34) FIG. 4 depicts the engagement of the first pusher 11 with the covered cavity of the blister package and the impact on the covered cavity 42, in terms of deformation of same. As a result of the first applied force, a rupture 41 in the bounding backing 24 is created, which promotes partial egress of the unit dosage form 43 contained therein, for example, when the bounding backing is a single layer flexible, penetrable backing. The relative positioning of the second pusher 12 is shown, whereby the second pusher has not yet engaged the covered cavity. In this aspect, the unit dosage form 43 is partially liberated from the packaging, in that an opening 41 in the backing has been created, however, the dosage form is not yet fully released from the blister package.

(35) FIG. 5a depicts the engagement of the first pusher 11 with the covered cavity of the blister package and the impact on the covered cavity 42, in terms of deformation of same, similar to that seen in FIG. 4. According to this aspect, the bounding backing of the blister package 21 however, is comprised of two layers, an inner layer 55 and an outer layer 59. In this depicted aspect, the engagement of the first pusher 11 with the covered cavity does result in some deformation of same 42, however the backing has not yet ruptured and the dosage form 54 is still fully contained within the blister package.

(36) As will be apparent to the skilled artisan, the engagement of the first pusher with the covered cavity of the blister pack will place the contents of same under tension/pressure, which is insufficient, in some aspects to pierce the double backing.

(37) FIG. 5b depicts engagement of the second pusher which in some aspects, is with greater applied force, or in some aspects, is of a magnitude/strength to expel the dosage form 54 from the blister. In this aspect, the further engagement of the proximal end 57 of the second pusher 12 with the top surface of the covered cavity under pressure 42, further deforms the surface and results in the unit dosage form 54 in turn, being completely released from the tensioned backing.

(38) In some aspects of the invention, the depilling devices facilitate egress of the dosage form from a blister pack in a controlled and automated manner.

(39) According to this aspect, and in some embodiments, the first pusher, second pusher or a combination thereof is operationally connected to a release means that promotes or facilitates creation of the first sufficient force, second sufficient force or a combination thereof, resulting in release of the dosage form from the blister.

(40) FIGS. 6a and 6b exemplify such controlled regulation at the level of the coordinated activity of the first and second pusher, as accomplished via the incorporation of a reciprocating crank shaft 61 in the device. Such reciprocating crank shaft 61 may be attached to a linking shaft 62, via respective and appropriate connectors 65 and 64. Such connectors, for example, may be simple pins or lateral extensions, facilitating joining of the respective parts for the coupled activity of same, as illustrated and described herein.

(41) The relative positioning of the reciprocating crank shaft assembly vis a vis the first pusher 11 is shown in FIG. 6a, as well.

(42) Rotation of the assembly in FIG. 6a about a horizontal axis is shown in FIG. 6b.

(43) According to this aspect, and in one embodiment, there is provided a linking shaft 62, which participates in coordinated activity with the reciprocating crank shaft 61 via further partial engagement of the tensioner part 66 during a portion of the full rotation of the reciprocating crank shaft 61. In some aspects, such arrangement promotes alternation between a pressurized and relaxed state, as the reciprocating crank shaft is revolved around the indicated axis in the direction of movement indicated by 69.

(44) According to this aspect, the tensioner part 66 of the reciprocating crank shaft 61 is engaged by a latching part 67 of the shaft 65 of the second pusher. When the reciprocating crank shaft 61 is rotated about the axis in the direction as shown in 69, for at least a partial revolution length of the crank shaft, the tensioner is latched via the latching part 67, which in turn causes tensioning of the spring 68, which is positioned over the shaft 58 of the second pusher 12, between the proximal end 57, which functions as a tamper, and the stabilizer pin 64.

(45) It will be appreciated that even extremely discreet minor fractional rotation of the reciprocating crank shaft 61 about the axis in the direction, e.g. as shown by 69 will facilitate latching and unlatching of the tensioner to actuate the pushers as described and the invention is not to be limited by the length of such partial revolution. In some embodiments, such revolution may be at least a quarter, or in some embodiments, at least a half, or in some embodiments, at least three quarters of a revolution, or in some embodiments, such revolution may be at least a tenth to at least a quarter-length revolution.

(46) FIG. 7 further extends the coordinated activity of the elements of the depilling device, now showing uncoupling of the reciprocating crank shaft and latching part, when the reciprocating crank shaft 61 is further rotated about the axis in the direction as shown in 69, from that shown in FIG. 6b. In this aspect, for at least the second half of the revolution length of the crank shaft, the tensioner 66 is no longer latched via the latching part 67, which in turn causes relaxation/release of the spring 68, as the shaft 58 of the second pusher 12 is propelled downward, until the latching part 67 abuts the stabilizer pin 64. As depicted, this enables propulsion of the second pusher toward the covered cavity to further deform same and promote full release of the unit dosage form 54 from the backing of the blister package.

(47) In some aspects, as will be readily appreciated by the skilled artisan, a reciprocating crank shaft may as well regulate engagement of the first pusher with the blister package as well as with the engagement of the second pusher. In some aspects a single reciprocating crank shaft may control the engagement of both the first pusher and second pusher, for example via the revolution around a tensioner or series of tensioners, the rotation around wish, and respective tensioning and relaxation of the respective controllers resulting in engagement of the first pusher and/or second pusher with the blister pack being regulated by for example, motors and appropriate circuitry to regulate engagement of same.

(48) In some aspects, different motors may regulate engagement of the first pusher and second pusher, for example by engaging different reciprocating crank shafts operationally connected to each.

(49) In some aspects, engagement of the first pusher may be via a switch and relay system that in turn initiates rotation of the reciprocating crank shaft operationally connected to the second pusher.

(50) The skilled artisan will readily appreciate that the reciprocating crank shaft may be comprised of any suitable material, and may comprise a plastic, resin, polymer, or other suitable material. In some aspects, such assembly may be constructed as a single piece, for example, via use of appropriate molds and known processes for preparing same. In other embodiments, individual parts may be suitable attached and in some embodiments, lithography or three-dimensional printing of parts is envisioned, as well.

(51) It will be apparent to the skilled artisan that the depilling devices of this invention may be further coupled to automating elements, for example, via the attachment of suitable motors or appropriate manual controls.

(52) FIG. 8 shows a side perspective view of the depilling device depicted in FIG. 6b, rotated 90 degrees from that shown in FIG. 6b, illustrating the potential for manual operation of the device. In this aspect, a rotating gear 75 engages a reciprocating geared element or lever 78, which can be advanced/engaged via a push button mechanism 82, as depicted. It will be appreciated by the skilled artisan that any number of mechanisms for manual operation are envisioned that allow for the actuation of the first and second pusher mechanisms as described.

(53) FIG. 9 shows a side perspective view of the depilling device depicted in FIG. 6b, rotated 90 degrees from that shown in FIG. 6b, illustrating the potential for attachment of a motor 80 to the reciprocating crank shaft 61.

(54) In some aspects a single motor may be coupled to multiple reciprocating crank shafts in a device of this invention, or in some embodiments, multiple motors may be coupled to multiple reciprocating crank shafts in a device of this invention.

(55) FIG. 10 further depicts the potential to further automate the depilling devices of this invention by, for example, coupling two or more depilling stations 90 and 91, respectively. The relative positioning of such stations with respect to a blister pack 94 containing two columns 92 of spaced unit dosage forms and the relative positioning of dosage form receiving apertures 93 through which the released unit dosage forms are ejected are exemplified, but the skilled artisan will readily appreciate the obvious potential alternate geometries and orientations which would be suitable, as well.

(56) FIG. 11 further depicts the versatility of the platform provided by the devices and methods of this invention. In this aspect, the positioning of the depilling device shown in FIG. 9, is changed to accomodate a circular blister pack array 102.

(57) It is understood that the above description of the embodiments of the present invention are for illustrative purposes only, and is not meant to be exhaustive or to limit the invention to the precise form or forms disclosed, as many modifications and variations are possible. Such modifications and variations are intended to be included within the scope of the present invention as defined by the accompanying claims.