Coolant mixtures

Abstract

The invention relates to coolant mixtures containing: (a) at least one compound of formula (I), (b) at least one compound of formula (II) in which R.sup.1 stands for hydrogen or a methyl group, R.sup.2 stands for a methyl, ethyl or propyl group and n stands for 0, 1, or 2, and if applicable (c) an additional component. ##STR00001##

Claims

1. A coolant mixture comprising: (a) at least one compound of the formula (I) ##STR00012## (b) at least one compound of the formula (II) ##STR00013## wherein R.sup.1 is in each case hydrogen or a methyl group, R.sup.2 is in each case a methyl, ethyl or propyl group and n is 0, 1 or 2; and (c) optionally a further coolant wherein said mixture comprises: (a) about 90 to about 99% by weight substances of the formula (I), (b) about 1 to about 10% by weight substances of the formula (II), and (c) 0 to about 90% by weight further coolants with the proviso that the components add up to 100% by weight.

2. The coolant mixture, according to claim 1, wherein, said mixture comprises isobutyraldehyde or isovaleraldehyde or mixtures thereof as component (a).

3. The coolant mixture, according to claim 1, wherein said mixture comprises isobutyric acid or isovaleric acid or mixtures thereof as component (b).

4. The coolant mixture, according to claim 1, wherein said mixture comprises one selected from menthol, menthyl acetate, and mixtures thereof as component (c).

5. The coolant mixture, according to claim 1 said mixture comprises at least one mixture of components (a) and (b) selected from: (i) isobutyraldehyde and isobutyric acid; (ii) isovaleraldehyde and isovaleric acid; (iii) isobutyraldehyde and isovaleric acid; (iv) isovaleraldehyde and isobutyric acid; and (v) isobutyraldehyde, isobutyric acid, isovaleraldehyde and isovaleric acid.

6. A preparation for oral administration comprising the coolant mixture, according to claim 1.

7. The preparation, according to claim 6, wherein said preparation takes a form of one selected from foodstuffs, pharmaceutical preparations, mouth compositions, dental care compositions, and combinations thereof.

8. The preparation, according to claim 7, wherein said preparation takes a form of one selected from hard candies, chewy candies, and chewing gums.

9. The preparation, according to claim 7, wherein said preparation takes a form of a cold remedy.

10. The preparation, according to claim 7, wherein said preparation takes a form of one selected from toothpastes, mouthwashes, and medicinal chewing gums.

11. The preparation, according to claim 6, wherein said preparation comprises the coolant mixture in an amount of from about 0.005 to about 5% by weight-based on the finished preparation.

12. A method for enhancing the cooling effect caused by a preparation on oral administration, the method comprising adding the coolant mixture, according to claim 1, to the preparation.

13. The preparation according to claim 9, wherein the cold remedy is one selected from syrups, sprays, and candies.

Description

EXAMPLES

(1) Performance Inventigations

Examples 1 to 6, Comparative Examples C1 to C4

(2) The cooling effect and flavor profile of various coolant mixtures were evaluated by a panel consisting of 5 trained testers. For this purpose, the mixtures were incorporated into an unsweetened and non-aromatized standard chewy candy preparation. The results are reported in table 1. The evaluation was reported according to the notation (5)=very true to (0)=largely not true. Data are mean values. Examples 1 to 6 are inventive while examples C1 to C4 serve as comparison.

(3) TABLE-US-00001 TABLE 1 Sensory evaluation of coolant mixtures Components C1 C2 C3 C4 1 2 3 4 5 6 Isobutyraldehyde 100 99 99 45 0.5 Isovaleraldehyde 100 99 99 45 Isobutyric acid 100 1 1 5 0.5 Isovaleric acid 100 1 1 5 Menthol 10 Menthyl acetate 89 Sensory evaluation Cooling effect is strong 3.2 3.1 3.0 3.1 4.2 4.4 4.1 4.4 4.6 4.9 Cooling effect occurs rapidly 2.1 2.0 2.2 2.5 3.8 3.5 3.7 3.6 4.1 4.4 Stinging taste 4.0 4.0 4.0 4.0 2.3 2.5 2.9 2.8 2.0 3.0 Pungent taste 4.0 4.0 3.9 3.8 2.5 2.1 2.1 2.4 2.3 2.8 Bitter taste 2.0 2.0 2.0 1.8 2.1 2.1 2.0 2.0 1.8 2.0

(4) The examples and comparative examples show that the mixtures according to the invention exert a greater and more rapid cooling effect and are assessed sensorially as significantly greater than the individual substances.

(5) A series of formulation examples are given below.

Example 1

(6) TABLE-US-00002 Toothpaste (figures as % by weight) COMPONENTS AMOUNT Water (deionized) to 100 Sorbitol 70% 45.00 Trisodium phosphate 0.10 Saccharin 0.20 Sodium monofluorophosphate 1.14 PEG 1500 5.00 Sident 9 (abrasive silica) 10.00 Sident 22 S (Thickening silica) 8.00 Sodium carboxymethylcellulose 1.10 Titanium (IV) oxide 0.50 Water (deionized) 4.50 Sodium lauryl sulfate (SLS) 1.50 Aroma mixture 1.00 Solbrol M (Sodium salt) (Methylparaben) 0.15 Coolant mixture I 0.40

Example 2

(7) TABLE-US-00003 Toothpaste with zinc citrate (figures as % by weight) COMPONENTS AMOUNT Water (deionized) to 100 Sorbitol 70% 45.00 Trisodium phosphate 0.10 Saccharin 0.20 Sodium monofluorophosphate 1.14 PEG 1500 5.00 Sident 9 (abrasive silica) 10.00 Sident 22 S (Thickening silica) 8.00 Sodium carboxymethylcellulose 1.10 Zinc citrate 1.00 Titanium (IV) oxide 0.50 Water (deionized) 4.50 Sodium lauryl sulfate (SLS) 1.50 Aroma mixture 1.00 SymDiol 68 (1.2-Hexanediol. Caprylyl glycol) 0.25 Coolant mixture II 0.10

Example 3

(8) TABLE-US-00004 Mouthwash (figures as % by weight) COMPONENTS AMOUNT Ethyl alcohol 10.00 Cremophor CO 40 (PEG 40 hydrogenated castor oil) 1.00 Aroma mixture 0.25 Water (deionized) To 100.00 Sorbitol 70% 5.00 Sodium saccharin 450 0.07 Sodium fluoride 0.18 Benzoic acid 0.12 Coolant mixture III 0.30

Example 4

(9) TABLE-US-00005 Dental gel (figures as % by weight) COMPONENTS AMOUNT Na carboxymethylcellulose 0.40 Sorbitol 70%. in water 72.00 Polyethylene glycol (PEG) 1500 3.00 Na saccarinate 0.07 Na fluoride 0.24 Aroma mixture 1.00 Abrasive silica 11.00 Thickening silica 6.00 Sodium dodecyl sulfate (SDS) 1.40 Dist. water to 100 p-Hydroxybenzoic acid (PHB) ethyl ester 0.15 Coolant mixture IV 0.20

Example 5

(10) TABLE-US-00006 Anti-plaque toothpaste (figures as % by weight) COMPONENTS AMOUNT Carrageenan 0.90 Glycerol 15.00 Sorbitol 70%. in water 25.00 PEG 1000 3.00 Na fluoride 0.24 Tetrapotassium diphosphate 4.50 Tetrasodium diphosphate 1.50 Na saccarinate 0.40 Precipitated silica 20.00 Titanium dioxide 1.00 Triclosan 0.30 Spearmint flavor (comprising 60 wt. % I-carvone 1.00 and 25 wt. % I-menthol) Sodium dodecyl sulfate 1.30 Dist. water to 100 Benzylalcohol 0.50 Coolant mixture V 0.25

Example 6

(11) TABLE-US-00007 Toothpaste for sensitive teeth (figures as % by weight) COMPONENTS AMOUNT Na carboxymethylcellulose 0.70 Xanthan gum 0.50 Glycerol 15.00 Sorbitol 70%. in water 12.00 Potassium nitrate 5.00 Sodium monofluorophosphate 0.80 Na saccharinate 0.20 Aroma mixture 1.00 Ca carbonate 35.00 Silicon dioxide 1.00 Sodium dodecyl sulfate (SDS) 1.50 Dist. water to 100 PHB methyl ester and PHB propyl ester 0.20 Coolant mixture I 0.50

Example 7

(12) TABLE-US-00008 Toothpaste and mouthwash 2:1 (figures as % by weight) COMPONENTS AMOUNT Sorbitol 40.00 Glycerol 20.00 Ethanol 5.00 Water to 100 Na monofluorophosphate 0.75 Saccharin 0.20 Sident 9 (abrasive silicon dioxide) 20.00 Sident 22 S (thickening silicon dioxide) 2.00 Sodium carboxymethylcellulose 0.30 Sodium lauryl sulfate (SDS) 1.20 Color (Suspension. 1% in water) C.I. Pigment Blue 15 0.50 Aroma mixture 0.90 Solbrol M. sodium salt (methylparaben. sodium salt) 0.20 Coolant mixture II 0.30

Example 8

(13) TABLE-US-00009 Mouthwash with fluoride (figures as % by weight) COMPONENTS AMOUNT Ethanol 7.00 Glycerol 12.00 Na fluoride 0.05 Pluronic F-127 (BASF. surface-active substance) 1.40 Na phosphate buffer pH 7.0 1.10 Na saccharinate 0.10 Aroma mixture 0.15 Chlorhexidine digluconate 0.2 Dist. water to 100 Sorbic acid 0.20 Coolant mixture III 0.30

Example 9

(14) TABLE-US-00010 Sugar-free chewing gum (figures as % by weight) COMPONENTS AMOUNT Chewing gum base 30.00 Sorbitol. powder to 100 Palatinite 9.50 Xylitol 2.00 Mannitol 3.00 Aspartame 0.10 Acesulfame K 0.10 Emulgum/emulsifier 0.30 Sorbitol 70%. in water 14.00 Glycerol 1.00 Aroma mixture 1.50 Coolant mixture IV 0.20