Porous bionic skull repairing material, preparation method and implement method thereof

Abstract

A porous bionic skull repairing material includes a polymer material, whose structure is consistent with that of a human skull. The surface layers of the porous bionic skull repairing material are dense layers which are composed of non-degradable or degradable polymer materials and has blind holes having an asymmetric structure, and the inner layer of the porous bionic skull repairing material is a loose layer which has a porous structure. The repairing material can be molded by adopting a mixed mould pressing method or a 3D printing method, simulates a bone structure, with two dense sides and a loose middle, of a human skull to the greatest extent.

Claims

1. A porous bionic skull repairing material, from inner to outer, successively comprising an inner dense layer, a loose layer and an outer dense layer, wherein the loose layer is located between the inner dense layer and the outer dense layer, and the inner dense layer and the outer dense layer are both connected with the loose layer, wherein the inner dense layer and the outer dense layer are both provided with asymmetrical blind hole structures; wherein, a diameter of each of the blind hole structures is 0.1 mm-10 mm, a gap between the blind hole structures is 1 mm-10 mm; the loose layer is of a porous structure with a pore size of 10-700 m and a porosity of 5%-90%.

2. The porous bionic skull repairing material according to claim 1, wherein the porous structure of the loose layer is a three-dimensional porous structure or a crossed pore-shaped structure.

3. The porous bionic skull repairing material according to claim 1, wherein the inner dense layer and the outer dense layer simulate a cortical bone structure, and the loose layer simulates a skull bone trabecula structure.

4. The porous bionic skull repairing material according to claim 1, wherein the porous bionic skull repairing material is configured to match with a human skull structure.

5. The porous bionic skull repairing material according to claim 1, wherein the inner dense layer and the outer dense layer are made of polymer materials, or made of a polymer material and a bioactive substance, and the materials of the inner dense layer and the outer dense layer can be the same or different, wherein, the polymer material is a non-degradable polymer material or a degradable polymer material; the loose layer is made of a polymer material and a porogen, or made of a polymer material, a porogen and a bioactive substance, wherein, the polymer material is a non-degradable polymer material or a degradable polymer material.

6. The porous bionic skull repairing material according to claim 5, wherein the porogen is an inorganic salt forming a three-dimensional porous structure or a metal wire forming a crossed pore-shaped structure, wherein a positive ion of the inorganic salt is a sodium ion or a potassium ion, a negative ion is at least one of a chlorine ion, a carbonate ion, a sulfate ion, a phosphate ion and a nitrate ion, wherein the inorganic salt is at least one of sodium chloride, sodium carbonate, potassium chloride, potassium sulfate, potassium carbonate and potassium phosphate, wherein the metal wire is formed by winding at least one of a magnesium wire, a zinc wire and an aluminum wire.

7. The porous bionic skull repairing material according to claim 5, wherein the non-degradable polymer material is a polyaryletherketone material, comprising at least one of polyetheretherketone (PEEK), polyetherketone (PEK), polyetherketoneketone (PEKK), polyetheretherketoneketone (PEEKK) and polyetherketoneetherketoneketone (PEKEKK); wherein the degradable polymer material is a polyester degradable polymer material comprising at least one of polylactic acid, polyglycollide and polycaprolactone; wherein the bioactive substance is at least one of nano hydroxyapatite (HAp), nano titania (TiO.sub.2), calcium silicate, -tricalcium phosphate and bioactive glass.

8. The porous bionic skull repairing material according to claim 1, wherein at least one of the inner dense layer, the outer dense layer and the loose layer contains an antibiotic component or an active factor; when being present in the inner dense layer or the outer dense layer, the antibiotic component or the active factor are located on the naked surface of the inner dense layer or the outer dense layer; when being present in the loose layer, the antibiotic component or/and the active factor are located on the naked surface of the loose layer and in the pores inside the loose layer.

9. The porous bionic skull repairing material according to claim 8, wherein the antibiotic component is at least one of a metal substance, a non-metal substance and an organic substance, the metal substance is at least one of a silver ion, a zinc ion, a copper ion, silver oxide, zinc oxide and copper oxide, the non-metal substance is a compound containing at least one of a hydrogen element, a chlorine element and a selenium element and having an antibacterial action, the organic substance is at least one of antibiotics, antimicrobial peptide and chitosan; the active factor is at least one of a bone Gla protein (BGP), a bone morphogenetic protein (BMP) and a basic fibroblast growth factor (BFGF).

10. The porous bionic skull repairing material according to claim 1, wherein the porous bionic skull repairing material is subjected to surface modification by virtue of one or more of the following a-g manners: a. treating the porous bionic skull repairing material with a gas cluster ion beam method; b. treating the porous bionic skull repairing material with a plasma method; c. treating the porous bionic skull repairing material with a surface covering method; d. treating the porous bionic skull repairing material with a laser irradiation method; e. treating the porous bionic skull repairing material with an electron beam deposition method; f. treating the porous bionic skull repairing material with an embedding method; and g. treating the porous bionic skull repairing material with an osmose method.

11. The porous bionic skull repairing material according to claim 1, wherein the porous bionic skull repairing material is prepared by using a 3D printing technology or a mixed mould pressing method.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 is a structural diagram of a porous bionic skull repairing material.

(2) FIG. 2 is a formation diagram of a board when in mixed mould pressing

(3) FIG. 3 is a plastic formation diagram of a board through a moldless forming technique when in mixed mould pressing.

(4) FIG. 4 is a local microcosmic enlarged view of a loose layer of a porous bionic skull repairing prosthesis prepared in example 1.

(5) FIG. 5 is a local microcosmic enlarged view of a loose layer of a porous bionic skull repairing prosthesis prepared in example 2.

(6) In the drawings, 1outer dense layer; 2loose layer; 3inner dense layer; 4core bar; 5mould barrel; 6demould seat; 7base mould; 8upper basic body of moldless multi-point molding equipment; 9porous bionic skull repairing material; 10lower basic body of moldless multi-point molding equipment.

DESCRIPTION OF THE EMBODIMENTS

(7) Next, embodiments of the disclosure are further described in detail in combination with accompanying drawings. It should be understood that these embodiments are used for illustrating the disclosure but not limiting the scope of the disclosure. Implementation conditions adopted in examples can be further regulated according to conditions of specific manufacturers, non-noted implementation conditions are generally conditions in conventional experiments.

Example 1

(8) 1. A skull of a patient is scanned by using a computed tomography technology, a scanned image is stored in a DICOM (Digital Imaging and Communication in Medicine) format, data is divided and extracted utilizing image processing software, a three-dimensional model for a skull and a defect part of a patient is rebuilt, and the size and curvature of the artificial skull of the defect part are calculated.

(9) 2. Preparation of a board:

(10) preparation of mixed powder: a loose layer mixed powder material is prepared in an ideal volume of 102% mould, namely, NaCl particles having a size of 250 m and PEEK powder having a grain size of 70 m are sufficiently mixed for 30 min with a planet ball mill at 200 rpm in a ratio of PEEK to NaCl of 80 wt %:20 wt % to prepare a mixed powder material as the loose layer mixed powder material; and the dense layer powder material is pure PEEK powder;

(11) preparation of a cold pressed sheet: the pure PEEK powder is poured into the bottom of the mould to be used as the inner dense layer, the loose layer mixed powder material is placed in the middle of the mould, then a layer of pure PEEK powder is paved on an upper layer to be used as the outer dense layer, the ready mould is placed in a hydraulic machine to compact the materials at a pressure of 30 MPa, pressurizing and pressure releasing are repeatedly carried out three times, the pressure is gradually raised when in pressurizing so that the residual gas in the mould is discharged, and the pressure is maintained for 5 min when achieving 30 Mpa, so as to ensure the quality and property of the product;

(12) melting: the cold pressed mould is placed on a high-temperature oven or an external heating device for melting and heating the material at a heating temperature of 390 C. but less than a boiling point of the porogen NaCl, so that PEEK is completely molten, wherein, heating time is 1 h;

(13) hot pressing: the mould in which the material is completely molten is quickly placed into a hydraulic machine for hot pressing, with a maximal set pressure of 15 MPa; pressurizing and pressure releasing are repeatedly carried out three times, the pressure is gradually raised when in pressurizing, and the pressure is maintained for 10 min after achieving 15 Mpa;

(14) cooling: the pressure is released from the press machine when the temperature is reduced to less than 300 C. after the pressure is maintained, and the mould is cooled at a speed of 40 C./min; and

(15) demoulding: when the temperature of the mould is reduced to less than 150 C., demouling is carried out to prepare a board with inner and outer dense layers and a middle loose layer, as shown in FIG. 1, wherein, the inner and outer dense layers are both provided with blind hole structures whose pore size is 1 mm and a gap is 3 mm; the loose layer has three-dimensional pores with a pore size of 250 m and a porosity of 20%; the thicknesses of the inner and outer dense layers are both 1.5 mm, and the thickness of the loose layer is 2 mm.

(16) 3. Plastic treatment: the built three-dimensional model for the skull defect part of the patient is guided into moldless multi-point molding equipment, the demoulded blank obtained in the above step is heated to 200 C., the heated blank is quickly transferred to the moldless multi-point molding equipment, compression molding is carried out to obtain the personalized skull repairing prosthesis customized according to the patient, and the skull repairing prosthesis is cut so that its size exceeds the size of calculated artificial skull by about 1 cm.

(17) 4. Preparation of a personalized porous bionic skull repairing prosthesis: the personalized skull repairing prosthesis obtained in the above step is placed into an ultrasonic water bath pot with a set temperature of 80 C. until the porogen is completely separated out, and subsequently, drying is carried out (for about 24 h) to obtain the porous bionic skull repairing prosthesis customized according to the patient.

(18) a. Mechanical Property Test

(19) The porous bionic skull repairing prosthesis obtained in step 4 is tested according to a method stipulated by GB/T1040.1-2006. Results are as follows:

(20) TABLE-US-00001 Yield strength Elongation ratio at breaking Elasticity modulus (MPa) (%) (GPa) 70 10.5 2.6

(21) b. Morphological Observation

(22) FIG. 4 is a local microcosmic enlarged view of the loose layer of the obtained porous bionic skull repairing prosthesis. It can be seen from the drawing that the loose layer has an obvious pore structure.

Example 2

(23) 1. A skull of a patient is scanned by using a computed tomography technology, a scanned image is stored in a DICOM (Digital Imaging and Communication in Medicine) format, data is divided and extracted utilizing image processing software, a three-dimensional model for a skull and a defect part of a patient is rebuilt, and the size and curvature of the artificial skull of the defect part are calculated.

(24) 2. Preparation of a board:

(25) preparation of mixed powder: a mixed powder material of dense layers and a loose layer is prepared in an ideal volume of 102% mould, namely, NaCl particles having a size of 250 m, PEEK powder having a grain size of 70 m and nm-HA (nano hydroxyapatite) having a grain size of 70 nm are sufficiently mixed for 30 min with V-shaped blender mixer at 200 rpm in a ratio of PEEK to NaCl to nm-HA of 70 wt %:20 wt %:10 wt % to prepare a mixed powder material as a loose layer mixed powder material; and the dense layer powder material is pure PEEK powder;

(26) preparation of a cold pressed sheet: the outer dense layer PEEK powder material is paved at the bottom of the mould, the loose layer mixed powder material is placed in the middle of the mould, then inner dense layer PEEK powder is paved on an upper layer, the ready mould is placed in a hydraulic machine to compact the materials at a pressure of 30 MPa, pressurizing and pressure releasing are repeatedly carried out three times so that the residual gas in the mould is completely discharged, the pressure is gradually raised when in pressurizing, and the pressure is maintained for 5 min when achieving 30 Mpa, so as to ensure the quality and property of the product;

(27) melting: the cold pressed mould is placed on a high-temperature oven or an external heating device for melting and heating the material at a heating temperature of 400 C. but less than a boiling point of the porogen NaCl so that the PEEK powder is completely molten, wherein, heating time is 1 h;

(28) hot pressing: the mould in which the material is completely molten is quickly placed into a hydraulic machine for hot pressing, with a maximal set pressure of 15 MPa; pressurizing and pressure releasing are repeatedly carried out three times, the pressure is gradually raised when in pressurizing, and the pressure is maintained for 10 min after achieving 15 Mpa;

(29) cooling: the pressure is released from the press machine when the temperature is reduced to less than 300 C. after the pressure is maintained, and the mould is cooled at a speed of 40 C./min; and

(30) demoulding: when the temperature of the mould is reduced to less than 150 C., a blank is demoulded to take out a board; as shown in FIG. 1, the inner and outer dense layers are both provided with blind hole structures whose pore size is 1.5 mm and a gap is 3.5 mm; the loose layer has three-dimensional pores with a pore size of 250 m and a porosity of 20%; the thicknesses of the inner and outer dense layers are 1.5 mm, and the thickness of the loose layer is 2 mm.

(31) 3. Plastic treatment: the built three-dimensional model for the skull defect part of the patient is guided into moldless multi-point molding equipment, the demoulded blank obtained in the above step is heated to 200 C., the heated blank is quickly transferred to the moldless multi-point molding equipment, compression molding is carried out to obtain the personalized skull repairing prosthesis customized according to the patient, and the skull repairing prosthesis is cut so that its size exceeds the size of calculated artificial skull by about 1 cm.

(32) 4. Preparation of a personalized porous bionic skull repairing prosthesis: the personalized skull repairing prosthesis obtained in the above step is placed into an ultrasonic water bath pot with a set temperature of 80 C. until the porogen is completely separated out, and subsequently, drying is carried out (for about 24 h) to obtain the porous bionic skull repairing prosthesis customized according to the patient.

(33) a. Morphological Observation

(34) FIG. 5 is a local microcosmic enlarged view of the loose layer of the obtained porous bionic skull repairing prosthesis. It can be seen from the drawing that hydroxyapatite and polyetheretherketone have a good interface compatibility.

(35) b. Mechanical Property Test

(36) The porous bionic skull repairing prosthesis obtained in step 4 is tested according to a method stipulated by GB/T1040.1-2006. Results are as follows:

(37) TABLE-US-00002 Yield strength Elongation ratio at breaking Elasticity modulus (MPa) (%) (GPa) 85 10.5 2.8

Example 3

(38) 1. A skull of a patient is scanned by using a computed tomography technology, a scanned image is stored in a DICOM (Digital Imaging and Communication in Medicine) format, data is divided and extracted utilizing image processing software, a three-dimensional model for a skull and a defect part of a patient is rebuilt, and the size and curvature of the artificial skull of the defect part are calculated.

(39) 2. Preparation of a board:

(40) preparation of mixed powder: a mixed powder material of dense layers and a loose layer is prepared in an ideal volume of 102% mould, namely, PEEK powder of 70 m and TiO.sub.2 of 70 nm are added into a V-shaped blender mixer in a ratio of PEEK to TiO.sub.2 of 90 wt %:10 wt % to be sufficiently and evenly mixed to prepare a dense layer powder material; a mixed powder material is prepared from KCl particles having a size of 250 m, PEEK powder having a grain size of 70 m and TiO.sub.2 powder of 70 nm are sufficiently mixed for 30 min with a planet ball mill at 200 rpm in a ratio of PEEK to KCl to TiO.sub.2 of 65 wt %:25 wt %:10 wt % to prepare the loose layer mixed powder material;

(41) preparation of a cold pressed sheet: the dense layer powder material is paved at the bottom of the mould, the loose layer mixed powder material is placed in the middle of the mould, the dense layer PEEK powder material is paved on an upper layer, the ready mould is placed in a hydraulic machine to compact the materials at a pressure of 30 MPa, pressurizing and pressure releasing are repeatedly carried out three times, the pressure is gradually raised when in pressurizing so that the residual gas in the mould is completely discharged, and the pressure is maintained for 4 min when achieving 30 Mpa, so as to ensure the quality and property of the product;

(42) melting: the cold pressed mould is placed on a high-temperature oven or an external heating device for melting and heating the material at a heating temperature of 390 C. but less than a boiling point of KCl so that PEEK is completely molten, wherein, heating time is 45 min;

(43) hot pressing: the mould in which the material is completely molten is quickly placed into a hydraulic machine for hot pressing, with a maximal set pressure of 15 MPa; pressurizing and pressure releasing are repeatedly carried out three times, the pressure is gradually raised when in pressurizing, and the pressure is maintained for 10 min after achieving 15 Mpa;

(44) cooling: the pressure is released from the press machine when the temperature is reduced to less than 300 C. after the pressure is maintained, and the mould is cooled at a speed of 40 C./min; and

(45) demoulding: when the temperature of the mould is reduced to less than 150 C., a board is demoulded and taken out; the structure of the board is as shown in FIG. 1, wherein, the inner and outer dense layers are both provided with blind hole structures whose pore size is 1.5 mm and a gap is 4 mm; the loose layer has three-dimensional pores with a pore size of 250 m and a porosity is 25%; the thicknesses of the inner and outer dense layers are 1 mm, and the thickness of the loose layer is 2 mm.

(46) 3. Plastic treatment: the built three-dimensional model for the skull defect part of the patient is guided into moldless multi-point molding equipment, the demoulded blank obtained in the above step is heated to 200 C., the heated blank is quickly transferred to the moldless multi-point molding equipment, compression molding is carried out to obtain the personalized skull repairing prosthesis customized according to the patient, and the skull repairing prosthesis is cut so that its size exceeds the size of calculated artificial skull by about 1 cm.

(47) 4. Preparation of a personalized porous bionic skull repairing prosthesis: the personalized skull repairing prosthesis obtained in the above step is placed into an ultrasonic water bath pot with a set temperature of 80 C. until the porogen is completely separated out, and subsequently, drying is carried out (for about 24 h) to obtain the porous bionic skull repairing prosthesis customized according to the patient.

(48) 5. The porous bionic skull repairing prosthesis in which the porogen is removed in the above step 4 is subjected to surface treatment using a gas cluster ion beam (GCIB) so as to improve the surface hydrophilicity of the prosthesis and facilitating adhesion of cells, thereby obtaining the porous bionic skull repairing prosthesis customized according to the patient.

(49) a. Mechanical Property Test

(50) The porous bionic skull repairing prosthesis obtained in step 5 is tested measured according to a method stipulated by GB/T1040.1-2006. Results are as follows:

(51) TABLE-US-00003 Yield strength Elongation ratio at breaking Elasticity modulus (MPa) (%) (GPa) 72 9.8 2.2

Example 4

(52) 1. A skull of a patient is scanned by using a computed tomography technology, a scanned image is stored in a DICOM (Digital Imaging and Communication in Medicine) format, data is divided and extracted utilizing image processing software, a three-dimensional model for a skull and a defect part of a patient is rebuilt, and the size and curvature of the artificial skull of the defect part are calculated.

(53) 2. Preparation of a board:

(54) preparation of mixed powder: a mixed powder material of dense layers and a loose layer is prepared in an ideal volume of 102% mould, namely, PEEK powder of 70 m and hydroxyapatite powder of 70 nm are put into a V-shaped blender mixer in a ratio of PEEK to hydroxyapatite of 90 wt %:10 wt % to be sufficiently and evenly mixed to prepare a dense layer powder material; Na.sub.2CO.sub.3 particles having a size of 600m, PEEK powder having a grain size of 70 m and hydroxyapatite of 70 nm are sufficiently mixed for 30 min with a planet ball mill at a rotation speed of 200 rpm in a ratio of PEEK to Na.sub.2CO.sub.3 to hydroxyapatite of 65 wt %:25 wt %:10 wt % to prepare a loose layer mixed powder material;

(55) preparation of a cold pressed sheet: the dense layer powder material is paved at the bottom of the mould, the loose layer powder material is placed in the middle of the mould, the dense layer powder material is paved on the upper layer, the ready mould is placed in a hydraulic machine to compact the materials at a pressure of 40 MPa, pressurizing and pressure releasing are repeatedly carried out three times, the pressure is gradually raised when in pressurizing so that the residual gas in the mould is discharged, and the pressure is maintained for 5 min when achieving 40 Mpa, so as to ensure the quality and property of the product;

(56) melting: the cold pressed mould is placed on a high-temperature oven or an external heating device for melting and heating the material, wherein, the temperature is set as 400 C., and heating time is 1 h;

(57) hot pressing: the mould in which the material is completely molten is quickly placed into a hydraulic machine for hot pressing, with a set pressure of 20 MPa; pressurizing and pressure releasing are repeatedly carried out three times, the pressure is gradually raised when in pressurizing, and the pressure is maintained for 10 min after achieving 20 Mpa;

(58) cooling: the pressure is released from the press machine when the temperature is reduced to less than 300 C. after the pressure is maintained, and the mould is cooled at a speed of 40 C./min; and

(59) demoulding: when the temperature of the mould is reduced to less than 150 C., a board is demoulded and taken out; the structure of the board is as shown in FIG. 1, wherein, the inner and outer dense layers are both provided with blind hole structures whose pore size is 2 mm and a gap is 4 mm; the loose layer has three-dimensional pores with a pore size of 600 m and a porosity of 25%; the thicknesses of the inner and outer dense layers are 1 mm, and the thickness of the loose layer is 2 mm.

(60) 3. Plastic treatment: the built three-dimensional model for the skull defect part of the patient is guided into moldless multi-point molding equipment, the demouded blank obtained in the above step is heated to 200 C., the heated blank is quickly transferred to the moldless multi-point molding equipment, compression molding is carried out to obtain the personalized skull repairing prosthesis customized according to the patient, and the skull repairing prosthesis is cut so that its size exceeds the size of the calculated artificial skull by about 1 cm.

(61) 4. Preparation of a personalized porous bionic skull repairing prosthesis: the personalized skull repairing prosthesis obtained in the above step is placed into an ultrasonic water bath pot with a set temperature of 80 C. until the porogen is completely separated out, and subsequently, drying is carried out (about 24 h).

(62) 5. Antibiotic tobramycin is loaded into the pores of the dried personalized porous bionic skull repairing prosthesis in step 4 utilizing an embedding method to form a personalized porous bionic skull repairing prosthesis having an antibacterial function.

(63) a. Mechanical Property Test

(64) The porous bionic skull repairing prosthesis having the antibacterial function obtained in step 5 is tested according to a method stipulated by GB/T1040.1-2006. Results are as follows:

(65) TABLE-US-00004 Yield strength Elongation ratio at breaking Elasticity modulus (MPa) (%) (GPa) 81 9.8 2.4

Example 5

(66) 1. A skull of a patient is scanned by using a computed tomography technology, a scanned image is stored in a DICOM (Digital Imaging and Communication in Medicine) format, data is divided and extracted utilizing image processing software, a three-dimensional model for a skull and a defect part of a patient is rebuilt, and the size and curvature of the artificial skull of the defect part are calculated.

(67) 2. Preparation of a board:

(68) preparation of mixed powder: in the loose layer, a wound magnesium wire is selected as a porogen, various raw materials are weighed in a ratio of polyaryletheretherketone (PEEK) to nano hydroxyapatite to the porogen of 80 wt %:5 wt %:15 wt %, polyaryletheretherketone (PEEK) and nano hydroxyapatite are added into a V-shaped blender mixer to be sufficiently and evenly mixed to prepare a loose layer mixed powder material;

(69) cold press molding: when in cold pressing, pure PEEK powder is added at the bottom of the mould for cold pressing to form a board, namely, an outer dense layer, then a wound magnesium wire is placed on the outer dense layer board, wherein, the diameter of the magnesium wire is 0.6 mm; the loose layer mixed powder material prepared in the above step is poured into the mould for pressing to form a loose layer, and finally, the pure PEEK powder is added on the loose layer, and pressurizing and pressure releasing are repeatedly carried out more than three times so as to prepare the cold pressed board, wherein, the pressure is set as 30 Mpa when in cold pressing, the pressure is gradually raised when in pressurizing, and the pressure is maintained for 5 min after achieving 30 Mpa;

(70) melting: the board obtained in the above step and the mould are integrally put into an external heating device, wherein, the temperature is heated to 390 C., and heating time is 1 h;

(71) hot press molding: the molten blank obtained in the above step is quickly placed into a press machine, pressurizing and pressure releasing are repeatedly carried out more than three times, the pressure is gradually raised when in pressurizing, and the pressure is maintained for 10 min after achieving 15 Mpa, and the blank is demoulded and taken out when the temperature is reduced to 150 C.; the structure of the board is as shown in FIG. 1, wherein, the inner and outer dense layers are both provided with blind hole structures whose pore size is 5 mm and a gap is 5 mm; the loose layer has three-dimensional pores with a pore size of 600 m and a porosity of 15%; the thicknesses of the inner and outer dense layers are 1.5 mm, and the thickness of the loose layer is 2 mm.

(72) 3. Plastic treatment: the built three-dimensional model for the skull defect part of the patient is guided into moldless multi-point molding equipment, the blank obtained in the above step is heated to 200 C., the heated blank is quickly transferred to the moldless multi-point molding equipment, compression molding is carried out so as to obtain the personalized skull repairing prosthesis customized according to the patient, and the skull repairing prosthesis is cut so that its size exceeds the size of calculated artificial skull by about 1 cm.

(73) 4. Preparation of a personalized porous bionic skull repairing prosthesis: the personalized skull repairing prosthesis obtained in the above step is placed into hydrochloric acid until the porogen is completely corroded, subsequently, the personalized skull repairing prosthesis is placed into an ultrasonic water bath pot to be sufficiently soaked to remove strong acid, and then drying is carried out (for about 24 h) to obtain the porous bionic skull repairing prosthesis customized according to the patient.

(74) a. Mechanical Property Test

(75) The porous bionic skull repairing prosthesis obtained in step 4 is tested according to a method stipulated by GB/T1040.1-2006. Results are as follows:

(76) TABLE-US-00005 Yield strength Elongation ratio at breaking Elasticity modulus (MPa) (%) (GPa) 76 9.4 2.3

Example 6

(77) The porous bionic skull repairing prosthesis is prepared according to the method in Example 1, and a difference is that the loose layer is a mixture of PEEK powder having a grain size of 70 m and NaCl powder having a grain size of 500m in a ratio of PEEK to NaCl of 20 wt %:80 wt %. The loose layer of the obtained porous bionic skull repairing prosthesis has three-dimensional pores with a pore size of 500 m and a porosity of 80%.

Example 7

(78) The porous bionic skull repairing prosthesis is prepared according to the method in Example 2, and a difference is that the loose layer is a mixture of NaCl particles having a grain size of 600 m, PEEK powder having a grain size of 70 m and hydroxyapatite having a grain size of 70 nm in a ratio of PEEK to NaCl to hydroxyapatite of 20 wt %:70 wt %:10 wt %. The loose layer of the obtained porous bionic skull repairing prosthesis has three-dimensional pores with a pore size of 600 m and porosity of 70%.

Example 8

(79) The personalized porous bionic skull repairing prosthesis having an antibacterial function is prepared according to the method in Example 4, and a difference is that the loose layer is a mixture of Na.sub.2CO.sub.3 particles having a grain size of 600 m, PEEK powder having a grain size of 70 m and hydroxyapatite having a grain size of 70 nm in a ratio of PEEK to Na.sub.2CO.sub.3 to hydroxyapatite of 25 wt %:65 wt %:10 wt %. The loose layer of the obtained porous bionic skull repairing prosthesis has three-dimensional pores with a pore size of 600 m and a porosity of 65%.

Example 9

(80) The personalized porous bionic skull repairing prosthesis having an antibacterial function is prepared according to the method in Example 5, and a difference is that the loose layer is a mixture of a wound magnesium wire having a diameter of 600m, PEEK powder having a grain size of 70 m and hydroxyapatite having a grain size of 70 nm in a ratio of PEEK to a magnesium wire to hydroxyapatite of 15 wt %:80 wt %:5 wt %. The loose layer of the obtained porous bionic skull repairing prosthesis has three-dimensional pores with a pore size of 600 m and porosity of 80%.