COMPOSITIONS CONTAINING BETA-NICOTINAMIDE MONONUCLEOTIDE AND CORDYCEPS SINENSIS AND USE THEREOF

Abstract

The invention discloses a composition containing -nicotinamide mononucleotide and Cordyceps sinensis. The ratio of -nicotinamide mononucleotide to Cordyceps sinensis can be 2-5:1. The composition has the effects of improving NAD+ level in vivo, repairing DNA, maintaining cell health, promoting NADP synthesis, and increasing immunity. The combination of -nicotinamide mononucleotide and Cordyceps sinensis can strengthen various effects, create synergistic effect, and thus the present composition is suitable for the majority of people.

Claims

1. A composition comprising: -nicotinamide mononucleotide and Cordyceps sinensis.

2. The composition according to claim 1, wherein the Cordyceps sinensis is an artificially fermented mycelium of Cordyceps sinensis.

3. The composition according to claim 1, wherein the weight ratio of -nicotinamide mononucleotide to Cordyceps sinensis is 2-5:1.

4. The composition according to claim 3, wherein the weight ratio of -nicotinamide mononucleotide and Cordyceps sinensis is 3:1.

5. The composition according to claim 1, comprising: 2-5 parts by weight of -nicotinamide mononucleotide; 1 part by weight of Cordyceps sinensis; 1.5-3 parts by weight of microcrystalline cellulose; and 0.03-0.12 parts by weight of magnesium stearate.

6. The composition according to claim 5, comprising: 3 parts by weight of -nicotinamide mononucleotide; 1 part by weight of Cordyceps sinensis; 2 parts by weight of microcrystalline cellulose; and 0.03 part by weight of magnesium stearate.

7. The composition according to claim 5, wherein the Cordyceps sinensis is an artificially fermented mycelium.

8. The composition according to claim 5, which is in the form of a solid preparation.

9. The composition according to claim 5, wherein the solid preparation is a capsule.

10. A method of improving NAD+ level of a subject, repairing DNA of a subject, maintaining cell health of a subject, or promoting NADP synthesis of a subject, using the composition according to claim 1.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0023] The Cordyceps sinensis suitable for the present invention includes artificially fermented mycelium of Cordyceps sinensis and natural Cordyceps sinensis. From the perspective of environmental protection, cost reduction and industrialization, artificially fermented mycelium of Cordyceps sinensis is more suitable for the present invention than natural Cordyceps sinensis. Artificially fermented mycelium of Cordyceps sinensis is a Cordyceps sinensis mycelium obtained by industrial fermentation of Hirsutella sinensis which is an anamorph of Cordyceps sinensis (Berkeley) Sacc. At present, a number of manufacturers can produce Cordyceps sinensis mycelium by artificial fermentation.

[0024] The weight ratio of -nicotinamide mononucleotide and Cordyceps sinensis used in the composition of the present invention can be 2-5:1, preferably 3:1.

[0025] The invention discloses a composition containing -nicotinamide mononucleotide and Cordyceps sinensis, comprising:

[0026] 2-5 parts by weight of -nicotinamide mononucleotide;

[0027] 1 part by weight of Cordyceps sinensis;

[0028] 1.5-3 parts by weight of microcrystalline cellulose; and

[0029] 0.03-0.12 part by weight of magnesium stearate.

[0030] According to some more preferred embodiments in the present invention, the composition of the invention comprises:

[0031] 3 parts by weight of -nicotinamide mononucleotide;

[0032] 1 part by weight of Cordyceps sinensis;

[0033] 2 parts by weight of microcrystalline cellulose; and

[0034] 0.03 part by weight of magnesium stearate.

[0035] The Cordyceps sinensis is preferably the artificially Fermented mycelium of Cordyceps sinensis, and the microcrystalline cellulose is preferably microcrystalline cellulose PH102.

[0036] The composition of the invention can be made into solid preparations, such as capsules, tablets, etc. Depending on the specific preparation, flavoring agent, colorant, coating (film coating, sugar coating) and the like can be added into the composition.

[0037] The composition disclosed in the invention is preferably made into capsules.

[0038] The solid preparation of the composition of the invention can be prepared by conventional methods.

[0039] The composition of the invention has the effects of improving a subject's (such as a human) NAD+ level in vivo, repairing the subject's DNA, maintaining the subject's cell health, promoting the subject's NADP synthesis, and also has the effect of increasing the subject's immunity.

[0040] The combination of -nicotinamide mononucleotide and Cordyceps sinensis in the invention can have improved efficacies than either component alone. Moreover, the combination has synergistic effect which is stronger than the sum of the effects of either -nicotinamide mononucleoside or Cordyceps sinensis alone. Therefore, the combination is suitable for the general population.

EXAMPLES

Example 1

[0041]

TABLE-US-00001 Raw and Auxiliary materials Amount (g) -nicotinamide mononucleotide 100 Cordyceps sinensis mycelium powder 50 microcrystalline cellulose PH102 75 magnesium stearate 1.5
The materials were mixed evenly and pressed to prepare tablets (1,000 tablets were obtained).

Example 2

[0042]

TABLE-US-00002 Raw and Auxiliary Materials Amount (g) -nicotinamide mononucleotide 1,500 Cordyceps sinensis mycelium powder 500 microcrystalline cellulose PH102 1,000 magnesium stearate 15
The materials were mixed evenly and filled into No. 1 gelatin hollow capsules to thereby obtain 10,000 capsules.

Example 3

[0043]

TABLE-US-00003 Raw and Auxiliary Materials Amount (g) -nicotinamide mononucleotide 25,000 Cordyceps sinensis mycelium powder 5,000 microcrystalline cellulose PH102 15,000 magnesium stearate 600
The materials were mixed evenly and filled into No. 0 gelatin hollow capsules to thereby obtain 100,000 capsules.