Multi-dosage tablet array

Abstract

Described is a multi-dosage array of tablets comprising one or more active substances, the tablets being coated and void of tablet portioning means so as to avoid contact of the tablet constituents upon handling by a user for the provision of a plurality of different dosages of the one or more active substances to a plurality of patients of different weight who are in need of the said one or more active substances, the dosage being dependent on the weight of the respective patient, the array of tablets comprising three or more tablet groups, each tablet group consisting of identical tablets having unique identification means and a unique dosage of the one or more active substances, the said tablets differing from tablets of another group of the array in at least the dosage of the said two or more active substances and in the identification means. Further described are a multi-dosage tablet array system, a medicament dosage comprising a plurality of the tablets of the multi-dosage array of tablets, a dosage comprising a plurality of the tablets of the multi-dosage tablet array, a method of providing a dosage of one or more active substances tailored to the body weight of a patient and a method of providing a tailored dosage of one or more active substances to the body weight of a patient.

Claims

1. A multi-dosage tablet array system, comprising: a plurality of multi-dosage arrays of tablets, each said tablet being coated and void of tablet portioning means, and each having one or more veterinary active substances for a treatment of an intended animal patient, all of the tablets in a single multi-dosage array having the same active substances, and all of the tablets in each different multi-dosage array having differing active substances, wherein each said multi-dosage array of tablets comprises three or more tablet groups, each said tablet group consisting of a plurality of identical tablets, each having a dosage of the one or more active substances tailored for a predetermined body weight of the intended animal patient, and an identifier that identifies the corresponding dosage, whereby tablets in the same tablet group having the same dosage also have the same identifier, wherein each of the tablets of each tablet group differ from each of the tablets of another tablet group within each said multi-dosage array in the dosage of the said one or more active substances and in the identifier, the dosage in the tablets of each tablet group being tailored to a different predetermined body weight of the intended animal patient and having a different identifier, and wherein the three or more tablet groups within each said multi-dosage array include tablet groups with dosages of the one or more active substances characteristic of that array, tailored to the same predetermined body weights of the intended animal patient, and the tablets of each tablet group of each said multi-dosage array that have a dosage tailored to the same predetermined body weight, having the same identifier.

2. The multi-dosage tablet array system of claim 1, wherein in each said multi-dosage array, the dosage of the one or more active substances in the tablets of the second tablet group is 2.5 times the dosage of the said one or more active substances in the tablets of the first tablet group, and the dosage of the one or more active substances in the tablets of the third tablet group is twice the dosage of the said one or more active substances in the tablets of the second tablet group.

3. The multi-dosage tablet array system of claim 1, wherein the identifier comprises a visual identifier.

4. The multi-dosage tablet array system of claim 3, wherein the visual identifier is the tablet color.

5. The multi-dosage tablet array system of claim 1, wherein each said multi-dosage tablet array comprises at least 4 tablet groups, wherein the dosage of the one or more active substances in the tablets of the fourth tablet group is twice the dosage of the said one or more active substances in the tablets of the third tablet group.

6. The multi-dosage tablet array system of claim 1, wherein each said multi-dosage tablet array comprises an additional tablet group wherein the dosage of the one or more active ingredients in the tablets of the said additional tablet group is half the dosage of the said one or more active substances in the tablets of the first tablet group.

7. The multi-dosage tablet array system of claim 1, wherein the animal patients of different weight belong to the same species.

8. The multi-dosage tablet array system of claim 1, wherein the animal patients of different weight are companion animals.

9. The multi-dosage tablet array system of claim 8, wherein the animal patients of different weight are canine.

10. The multi-dosage tablet array system of claim 1, wherein the tablets of the first tablet group of each of said multi-dosage arrays have a dosage of the one or more active substances tailored for an animal patient having a body weight of about 2 kg.

11. A dosage of a plurality of active substances comprising a plurality of the tablets of one or more arrays of the array system of claim 1.

12. A method of providing a dosage of a plurality of active substances for an animal patient, comprising providing a plurality of tablets from one or more of the multi-dosage tablet array system of claim 1.

13. A method of providing a dosage of a plurality of active substances tailored to the body weight of an animal patient according to claim 12, comprising the steps of: determining the weight of the animal patient, and combining a plurality of tablets from one or more of said multi-dosage arrays of tablets, such that the dosage of the one or more active substances of the said plurality of tablets from each array corresponds with the animal patient weight determined in said determining step.

14. The method of claim 13, wherein said combining step comprises combining tablets from different tablet groups from the one or more multi-dosage arrays of tablets.

Description

(1) FIG. 1 shows a dosing scheme of a multi-dosage tablet array as described above, comprising four tablet groups (A-D), each indicated by unique visual identification means, allowing the tablets from the different groups to be discriminated from one another. Tablets of group A (open circles) have a medicament dosage that is tailored for (i.e. corresponds with) a body weight of up to 2 kg for an envisaged patient, e.g. 8 mg. Tablets of group B (circles with dots) have a dosage that is tailored for a body weight of 5 kg for the same envisaged patient, in this example 20 mg. Tablets of group C (hatched circles) have a dosage that is tailored for a body weight of 10 kg for the same envisaged patient, in this example 40 mg, and tablets of group D (circle with horizontal lines) have a dosage that is tailored for a body weight of 20 kg for the same envisaged patient, in this example 80 mg. By combination of tablets from one or more groups, almost any body weight-dependent dosage can be obtained. By providing another multi-dosage tablet array, comprising tablets having another medicament or medicament combination, the very same dosing scheme can be applied. Of course, the dosage of the medicaments can vary per array, as for the one medicament 8 mg is suitable for 2 kg body weight, whereas for another medicament only 2 mg may be suitable for that body weight of 2 kg. The arrays and system that comprises different arrays highly facilitate the proper dosing of tableted medicaments for patients, without being in contact with any critical compounds of the tablet constituents and without the need of further manipulation of the tablets.

(2) FIG. 2 shows a multi-dosage array system for three different medicaments, each array comprising four tablet groups, the tablets of the first group (Tab 1) being red (open circles), of the second group (Tab 2) being blue (dotted circles), of the third group (Tab 3) being yellow (hatched circles) and of the fourth group (Tab 4) being green (lined circles). The first array, shown in FIG. 2A, comprises tablets comprising the active substance prednisolone for dogs, wherein the dose corresponds with 1 mg/kg. The first (red) tablet group has a prednisolone dosage of 2 mg, i.e. tailored for a predetermined body weight of 2 kg of the dog. The second (blue) tablet group has a dosage of 5 mg, i.e. tailored for a predetermined body weight of 5 kg of the dog. The third (yellow) tablet group has a dosage of 10 mg, i.e. tailored for a predetermined body weight of 10 kg of the dog. The fourth (green) tablet group has a dosage of 20 mg, i.e. tailored for a predetermined body weight of 20 kg of the dog. As can be seen in FIG. 2A, a dog of 4 kg total body weight will receive two prednisolone tablets of the first tablet group, each tablet being dosed for a predetermined body weight of 2 kg. A dog of 7 kg will receive a single tablet from group 1 and a single tablet from group 2. Accordingly, a dog of 15 kg will receive a single tablet from group 2 and a single tablet from group 5. Accordingly, a dog having a body weight of 17 kg will receive an additional tablet from the first tablet group. A large dog of 40 kg will receive 2 green tablets.

(3) In FIG. 2B, a second array of the system is shown wherein the tablets comprise the active substance amoxicillin for dogs and cats, wherein the dose corresponds with 10 mg/kg. The first (red) tablet group has an amoxicillin dosage of 20 mg, i.e. tailored for a predetermined body weight of 2 kg of the dog or cat. The second (blue) tablet group has a dosage of 50 mg, i.e. tailored for a predetermined body weight of 5 kg of the dog/cat. The third (yellow) tablet group has a dosage of 100 mg, i.e. tailored for a predetermined body weight of 10 kg of the dog/cat. The fourth (green) tablet group has a dosage of 200 mg, i.e. tailored for a predetermined body weight of 20 kg of the dog/cat. As can be seen in FIG. 2B, a dog or cat of 4 kg total body weight will receive two amoxicillin tablets of the first tablet group, each tablet being dosed for a predetermined body weight of 2 kg. A dog or cat of 7 kg will receive a single tablet from group 1 and a single tablet from group 2. Accordingly, a dog or cat of 15 kg will receive a single tablet from group 2 and a single tablet from group 5, and a dog or cat having a body weight of 17 kg will receive an additional tablet from the first tablet group.

(4) In FIG. 2C, a third array of the system is shown wherein the tablets comprise the active substance benazepril for dogs and cats, wherein the dose corresponds with 0.25 mg/kg. The first (red) tablet group has an amoxicillin dosage of 0.5 mg, i.e. tailored for a predetermined body weight of 2 kg of the dog or cat. The second (blue) tablet group has a dosage of 1.25 mg, i.e. tailored for a predetermined body weight of 5 kg of the dog/cat. The third (yellow) tablet group has a dosage of 2.5 mg, i.e. tailored for a predetermined body weight of 10 kg of the dog/cat. The fourth (green) tablet group has a dosage of 5 mg, i.e. tailored for a predetermined body weight of 20 kg of the dog/cat. As can be seen in FIG. 2B, a dog or cat of 4 kg total body weight will receive two benazepril tablets of the first tablet group, each tablet being dosed for a predetermined body weight of 2 kg. A dog or cat of 7 kg will receive a single tablet from group 1 and a single tablet from group 2. Accordingly, a dog or cat of 15 kg will receive a single tablet from group 2 and a single tablet from group 5, and a dog or cat having a body weight of 17 kg will receive an additional tablet from the first tablet group.