CARTRIDGE WITH SINGLE-LAYER CONTAINER AND ITS NOZZLE-SHAPED CAP FOR NEBULIZATION INHALATION

Abstract

The present invention is directed to a single-layer cartridge, and a process for producing a plastic single-layer container included in the cartridge. The single-layer cartridge comprises a plastic single-layer container, a seal and a nozzle-shaped cap or stopper, wherein the single-layer cartridge can be used to connected with a soft mist inhalation device or inhalation atomizer.

Claims

1. An inhalation device comprising a cartridge comprising a single-layer plastic container, an opening, and a nozzle-shaped cap or stopper, wherein the cartridge is connected to a soft mist inhalation device.

2. The inhalation device according to claim 1, wherein the nozzle-shaped cap or stopper is connected to the singe-layer container by means of a snap-in connection.

3. The inhalation device according to claim 1, wherein the cartridge further comprises a transfer bed to support the snap-in connection action.

4. The inhalation device according to claim 1, wherein the stopper comprises a plastic material that is non-releasably connected to the single-layer plastic container.

5. The inhalation device according to claim 1, further comprising a sealing disc provided with sealing beads, wherein the sealing disc is disposed between an upper surface of the container and an inside surface of the stopper.

6. The inhalation device according to claim 1, configured such that the cartridge can be pulled out of the soft mist inhalation device by means of a withdrawal aid.

7. The inhalation device according to claim 1 further comprising a rigid outer casing that the cartridge can be inserted into.

8. The inhalation device according to claim 1, further comprising a dispensing device, wherein the dispensing device is provided with snap hook that enables the dispensing device to lock with an upper part of the rigid outer casing after the cartridge has been inserted into the rigid outer casing.

9. The inhalation device according to the claim 1, wherein the single-layer cartridge is connected to the soft mist inhalation device by a push plug-in connection or a bayonet connection.

10. The inhalation device according to claim 1, further comprising a pharmaceutical liquid comprising a pharmaceutically active substance.

11. The inhalation device according to claim 10, wherein the pharmaceutical liquid is selected from the group consisting of water, alcohol, or a combination thereof.

12. The inhalation device according to claim 1, wherein the single-layer plastic container has a thickness of between about 0.05 mm and about 1.0 mm.

13. The inhalation device according to claim 12, wherein the single-layer plastic container has a thickness of between about 0.1 mm and about 0.3 mm.

14. The inhalation device according to claim 1, wherein the single-layer plastic container has a length of between about 20 mm and about 70 mm.

15. The inhalation device according to claim 14, wherein the single-layer plastic container has a length of between about 40 mm and about 55 mm.

16. The inhalation device according to claim 15, wherein the single layer plastic container has a length of between about 45 mm and about 50 mm.

17. The inhalation device according to claim 1, wherein the single layer plastic container is formed by an injection-blow-molding process.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0013] FIG. 1 shows a complete overview of the single-layer cartridge.

[0014] FIG. 2 shows a schematic presentation of the single-layer plastic container with cross section in the direction of the container central axis through the base area as an embodiment of the container.

[0015] FIG. 3 shows a schematic representation of a cross-section view of the nozzle-shaped stopper of the container through the central axis

[0016] FIG. 4 shows a schematic representation of a top view of the nozzle-shaped stopper.

[0017] FIG. 5 shows a cross section view of the soft silicon type material disc.

[0018] FIG. 6 shows a schematic top view of the soft silicon type material disc.

[0019] FIG. 7 shows a compressed negative pressure effect of the single-layer cartridge.

[0020] FIG. 8 shows a schematic section of a typical soft mist inhalation device.

[0021] The use of identical or similar reference numerals in different figures denotes identical or similar features.

DETAILED DESCRIPTION OF THE INVENTION

[0022] The present invention relates to a single-layer cartridge, and a process for producing a plastic single-layer container included in the cartridge. The single-layer cartridge comprises a plastic single-layer container, a seal and a nozzle-shaped cap or stopper, wherein the single-layer cartridge can be connected to a soft mist inhalation device or inhalation atomizer. The single-layer cartridge may be further fitted into and/or protected by a metallic or aluminum canister.

[0023] FIG. 1 shows a complete view of the single-layer cartridge comprising the single-layer plastic container and a nozzle shape cap or a stopper. FIG. 2 shows a cross section in the direction of the single-layer plastic container center axis 10, wherein the container wall based on single layer 1 has space 2 for a pharmaceutical formulation solution inside the container. The single-layer cartridge has a cap or stopper lock key 5 projections disposed on the end of the container neck 7 where the single-layer plastic container opening inlet space of cap or stopper 3 nozzle and sealing surface 4 are located. The single-layer plastic container has a transfer bed 8 in between the container neck and slant surface 9 of the container. The transfer bed provides support for the nozzle shaped cap or stopper snap action.

[0024] FIG. 3 and FIG. 4 show the nozzle-shaped cap or stopper, wherein the dispensing or soft mist inhalation device or draw-off connection portion has already penetrated the sealing foil on the top side of the top portion 18 and the outlet part 21 of the cap.

[0025] The inlet sealing slant provides cannula-free moment space 22, the free moment space 22 penetrates into the neck space insertion connection portion 6 which is sealed with silicon material 20 and is joined to the container sealing surface 4 on its cap or stopper. The stopper is held at its top side by a flanged over portion of the upper end of the stiff casing. The cartridge can be sealed by the stopper with the tight sealing disc 24 which closes to the open end of the capillary tube insertion portion.

[0026] FIG. 5 and FIG. 6 show a sealing disc 24, which is disposed between the upper edge of the container and inlet/outlet space 25 on silicon type material disc inside of the cap or stopper of the cartridge. Disposed between the upper edge sealing surface 4 of the container and the underside of the stopper is the sealing disc 24 having cap locking tab 15. The cap or stopper is held at its top side by a flanged over portion of the upper end of the stiff casing. The cartridge can be sealed by a nozzle-shaped cap or stopper with the tight sealing disc 24 which closes the open end of the capillary tube insertion portion. The cartridge comprises a capillary tube inside a cannula. The capillary breaks the seal of the cap outlet 20 and goes inside the space of container 2.

[0027] FIG. 7 shows a complete view of a compressed container with the negative pressure effect on the container wall after usage of medicine. When the capillary tube is inserted inside the cartridge, it breaks the seal of the cap or stopper and goes into the cannula while breaking the cap outlet seal 20, and the capillary tube enters inside the container space 2. With the usage of medicine, the container wall 1 is compressed because of the negative pressure. Because the pressure inside the container is lower than the surrounding pressure, this mechanism increases the vacuum inside the container. The compressed negative pressure effect can clearly be seen on the container wall.

[0028] The single-layer cartridge according to the current invention can be used with a soft mist inhalation device as shown in FIG. 3 and FIG. 4 of US20190030268 inhalation atomizer comprising a blocking function and a counter. The typical inhalable device can be carried anywhere by the patient, since it has a cylindrical shape and a handy size of less than about 8 cm to about 18 cm long, and about 2.5 cm to about 5 cm wide. The nebulizer sprays a defined volume of the pharmaceutical formulation solution out through small nozzles at high pressures, so as to produce an inhalable aerosol.

[0029] The typical inhalation atomizer comprising the block function and the counter described above for spraying a medicament fluid is depicted in FIG. 8. The inhalation atomizer comprising the block function and the counter described above is preferably a portable inhaler that requires no propellant gas.

[0030] The subject of the present invention not only ensures the individual claims, but also the combination of the individual claims. All information and features disclosed in the documentation, including the abstract and, in particular, the structures shown in drawings, are claimed as substantial to the invention insofar as they are novel individually or in combination to the prior art. The innovation is described in more detail with reference to drawings showing several embodiments, features and advantages of significance to the invention which ensue from the drawings.

[0031] While various embodiments of the present invention have been described above, it should be understood that they have been presented by way of example only, and not limitation. For example, the present invention is not limited to the physical arrangements or dimensions illustrated or described. Nor is the present invention limited to any particular design or materials of construction. As such, the breadth and scope of the present invention should not be limited to any of the above-described exemplary embodiments, but should be defined only in accordance with the following claims and their equivalents.

LIST OF REFERENCE NUMERALS USED IN THE FIGURES

[0032] 1. Single-layer wall plastic container [0033] 2. Pharmaceutical formulation solution space inside the container [0034] 3. Inlet space of cap or stopper nozzle [0035] 4. Sealing surface [0036] 5. Cap or stopper lock key [0037] 6. Neck space [0038] 7. Container Neck [0039] 8. Transfer Bed [0040] 9. Slant surface [0041] 10. Container central axis [0042] 11. Upper part Cap with snap-in key [0043] 12. Silicon bed hook [0044] 13. Outer surface of cap nose [0045] 14. Cap or stopper nozzle [0046] 15. Cap or stopper locking tab [0047] 17. Cap closing space [0048] 18. Inlet Opening [0049] 19. Inlet sealing slant [0050] 20. Cap or stopper outlet Sealing [0051] 21. Out let in cap or stopper [0052] 22. Cannula free movement space [0053] 23. Cap or stopper outer surface [0054] 24. Cap Sealing Disc [0055] 25. Inlet/outlet space on silicon type material disc [0056] 26. Compressed effect