Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application

Abstract

The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. ##STR00001## The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.

Claims

1. An isothiazole oxime ether-containing strobilurin compound, wherein the compound is: ##STR00038##

2. A composition comprising an isothiazole oxime ether-containing strobilurin compound, wherein the compound is: ##STR00039## or a combination thereof.

3. The composition of claim 2, wherein the composition is formulated as an insecticide composition, a fungicide composition, an antiviral composition, an acaricide composition, a tobacco mosaic virus agent composition, a pesticide composition, a plant elicitor composition, or a plant activator composition.

4. The composition of claim 2, wherein the isothiazole oxime ether-containing strobilurin compound is present in the composition in an amount between 1%-90% by mass percentage.

5. The composition of claim 2, further comprising: one or more insecticides; one or more fungicides; one or more anti-plant virus agents; or one or more acaricides.

6. The composition of claim 5, wherein a mass ratio of the isothiazole oxime ether-containing strobilurin compound to the one or more insecticides, the one or more fungicides, the one or more anti-plant virus agents, or the one or more acaricides is from 99%:1% to 1%:99%.

7. The composition of claim 2, wherein the composition is formulated as a suspension concentrate for seed treatment, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, block bait, granular bait, flake bait, concentrated bait, slow release block, electrostatic spray formulation, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, hot spray formulation, cold spray formulation, aerosol, solid liquid mixing agent, liquid/liquid mixing agent, solid/solid mixing agent, lacquer, granule, tracking powder, oil suspension, oil dispersible powder, thickener, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra-low volume liquid agent, or steam release agent.

8. A method of controlling a plant disease or a plant pest, the method comprising: applying an isothiazole oxime ether-containing strobilurin compound to one or more plants or to one or more insects to control a plant disease or a plant pest, wherein the isothiazole oxime ether-containing strobilurin compound is: ##STR00040## or a combination thereof.

9. The method of claim 8, wherein applying an isothiazole oxime ether-containing strobilurin compound to one or more plants or to one or more insects comprises applying the isothiazole oxime ether-containing strobilurin compound to control agricultural, forestry, or horticultural plant pests.

10. The method of claim 8, wherein applying an isothiazole oxime ether-containing strobilurin compound to one or more plants or to one or more insects to control a plant disease or a plant pest comprises applying an insecticidal composition comprising the isothiazole oxime ether-containing strobilurin compound to the one or more plants to control the plant pest, the one or more plants comprising rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, tapioca, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture, peanut, rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, rape, Onions, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, or bonsai, and the plant pest comprising Tetranychus cinnbarinus, Locusta migratoria manilensis, cypress locust, rice blast, Japanese yellow ridge, single locust, oriental carp, rice locust, scorpion horse, greenhouse hummer, rice tube hummer, wheat tube hummer, greenhouse whitefly, whitefly, black-tailed leafhopper, big green leafhopper, cotton leafhopper, spotted wax hopper, brown plant hopper, white-backed plant hopper, gray plant hopper, sugarcane, squared cornucopia, cotton aphid, wheat Fork, wheat long tube, peach aphid, sorghum, radish, blown sorghum, mulberry scorpion, scorpion shield, pear round scorpion, white wax worm, red wax scorpion, Korean ball scorpion, stephanitis nashi esaki et takeya, Banana nets, fine-horned flower buds, tiny flower buds, needle-edge mites, rice spider mites, rice brown mites, rice black mites, rice green mites, green blind mites, ticks, black scorpions, large grass mites, licao, chinese grasshopper, moth, moth, yellow moth, brown moth, flat moth, wheat moth, cotton bollworm, sweet potato moth, diamondback moth, peach small heartworm, soybean heartworm, peach small carnivorous worm, apple leaf roller moth, brown leaf moth, yellow leaf moth, sorghum, pea pod, corn borer, stem borer, rapeseed meal, rice leaf roller, stripe, roller leafhopper, peach aphid, armyworm, Spodoptera litura, rice blast, cotton small bridge worm, beet armyworm, giant salamander, cotton bollworm, dingdian diamond, small tiger, earth tiger, yellow tiger, toxic moth, gypsy moth, sweet potato hawk moth, bean hawk moth, straight grain rice butterfly, cryptic valley butterfly, citrus phoenix butterfly, jade belt phoenix butterfly, cabbage butterfly, ramie red butterfly, ramie butterfly, bean phthalocyanine, venus carapace, wrinkle-skinned armor, wheat-spotted armor, ditch-gold needle, fine-necked Golden Needle, G. striata, Black-skinned scorpion, citrus small jiding, lampralimbatagebler, Tenebrio molitor, Black mealworm, tribolium castaneum herbst, Tribolium confusum jac. du val., patina, golden tortoise, dark golden tortoise, north China black scorpion golden tortoise, mulberry ox, star celestial, orange brown hornbill, peach red neck horn, big worm leaf worm, small cockroach Leaf worm, yellow squash, yellow scalloped beetle, mung bean elephant, pea elephant, broad bean elephant, corn elephant, rice elephant, Dolerus Chu, pear fruit sawfly, yellow belt wasp, armyworm white star wasp, Chrysalis suspense, Campoletis chlorideae Uchida, Verruca verruca, mosquito, fly, horsefly, wheat blossom midge, wheat midge, rice gall midge, Tetradacus citri, Melon fruit fly, wheat fly ash, Leafminer, soybean stem borer, wheat straw flies, seed fly, onion fly, carrot fly, Exorista civilis Rondani, Mailing flies of corn borer, or armyworm.

11. The method of claim 8, wherein applying an isothiazole oxime ether-containing strobilurin compound to one or more plants or to one or more insects to control a plant disease or a plant pest comprises applying a fungicidal composition comprising the isothiazole oxime ether-containing strobilurin compound to the one or more plants to control the plant disease, the one or more plants comprising rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, tapioca, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture, peanut, rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, rape, Onions, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, or bonsai, and the plant disease comprising rice seedling cotton rot, tomato root rot, potato late blight, tobacco black shank, millet powdery mildew, grape downy mildew, lettuce downy mildew, cucumber downy mildew, or cucumber anthracnose.

12. The method of claim 8, wherein applying an isothiazole oxime ether-containing strobilurin compound to one or more plants or to one or more insects to control a plant disease or a plant pest comprises applying an antiviral composition comprising the isothiazole oxime ether-containing strobilurin compound to the one or more plants to control the plant disease, the one or more plants comprising rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, cassava, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture, peanuts, rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, Rape, onion, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, or bonsai, and the plant disease comprising rice dwarf disease, yellow dwarf disease, stripe leaf blight, tomato fern leaf virus disease, pepper mosaic virus disease, tobacco vein necrosis virus disease, corn dwarf mosaic disease, cauliflower mosaic virus, citrus virus disease, orchid leaf Virus, or Jianlan ring spot virus.

13. The method of claim 8, wherein applying an isothiazole oxime ether-containing strobilurin compound to one or more plants or to one or more insects to control a plant disease or a plant pest comprises applying an acaricide composition comprising the isothiazole oxime ether-containing strobilurin compound to the one or more plants to control the plant pest, the one or more plants comprising rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, tapioca, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture, peanuts, rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, Rape, onion, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, or bonsai, and the plant pest comprising the genus Aphididae, the genus Diptera, the eucalyptus, the genus Eucalyptus, or mites.

14. The method of claim 8, further comprising co-administering the isothiazole oxime ether-containing strobilurin compound with one or more insecticides, one or more fungicides, one or more anti-plant virus agents, or one or more acaricides.

Description

EXAMPLE 1

General Procedure for the Synthesis of Compounds II

(1) A solution of compound I (1.10 mmol) in 15 ml ethanol was added to the solution of intermediates 3,4-dichloroisothiazole-5-substituted carbonyl compounds (1.02 mmol) in ethanol (15 ml), wherein 3,4-dichloroisothiazole-5-substituted carbonyl compounds are chosen from 3,4-dichloroisothiazole-5-carbaldehyde, 1-(3,4-dichloroisothiazol-5-yl)ethanone, and 4-(3,4-dichloroisothiazol-5-yl)but-3-en-2-one. And to the reaction mixture was added the catalytic amount of hydrochloric acid (2 mol/L) and stirred at room temperature overnight. The solvent was evaporated under reduced pressure and the residue was then purified by recrystallization in ethanol or column chromatography on silica gel using ethyl acetate and petroleum ether (b.p. 60-90 C.) with 1:9 of v/v as an eluent to obtain II in a 70-80% yield; Wherein R.sup.1 is methyl; Y is (CHCH).sub.m, m=0; Z is N, .sup.1H NMR (CDCl.sub.3) 7.51 (s, 1H, Ph-H), 7.47-7.43 (m, 2H, Ph-H), 7.24-7.20 (m, 1H, Ph-H), 5.23 (s, 2H, Ph-CH.sub.2), 4.06 (s, 3H, OCH.sub.3), 3.83 (s, 3H, OCH.sub.3), 2.52 (s, 3H, NCCH.sub.3). The amount of compound II preparation and the volume of the reaction vessel increase or decrease in corresponding proportions. The yields, physical properties, .sup.1H NMR data of the compounds II are listed in Table 1.

EXAMPLE 2

General Procedure for the Synthesis of the Other Compounds II

(2) A solution of compounds I (1.10 mmol) in 15 ml ethanol was added to the solution of commercially available 3,4-dichloroisothiazole-5-carbonitrile (1.00 mmol) in ethanol (15 ml), 2-mercaptoacetic acid (0.10 g, 1.09 mmol) was added to the reaction mixture for stirring at room temperature overnight. The solvent was evaporated under reduced pressure and the residue was then purified by recrystallization in ethyl acetate or column chromatography on silica gel using ethyl acetate and petroleum ether (b.p. 60-90 C.) with 1:10 of v/v as an eluent to give II in a 80-97% yield. Wherein R.sup.1 is amino; Y is (CHCH).sub.m, m=0; Z is N, .sup.1H NMR (CDCl.sub.3) 7.40-7.30 (m, 3H, Ph-H), 7.13 (d, J=6.4 Hz, 1H, Ph-H), 5.18 (s, 2H, NH.sub.2), 4.91 (s, 2H, Ph-CH.sub.2), 3.97 (s, 3H, OCH.sub.3), 3.79 (s, 3H, OCH.sub.3) The yields, physical properties, .sup.1H NMR data of the compounds II are listed in Table 1.

EXAMPLE 3

General Procedure for the Synthesis of the Other Compounds III

(3) One of intermediates II (2.49 mmol) was dissolved in 15 ml methanol, the solution of sodium hydroxide (0.30 g, 7.47 mmol) in 15 ml methanol was added to the reaction mixture for 30 minutes of refluxing. After completing of the reaction, the solvent was evaporated under reduced pressure and to the residue was added 15 ml water. The aqueous phase was adjusted to pH 2-3 with dilute hydrochloric acid (3 mol/L). The aqueous layer was extracted with ethyl acetate (215 ml). The organic layers were combined and washed with saturated brine (50 ml), dried over sodium sulfate. After filtration, the solvent was evaporated to obtain the compounds III as a white solid in a 95% yield.

EXAMPLE 4

General Procedure for the Synthesis of the Other Compounds IV

(4) The reaction mixture of the compound III (0.75 mmol), EDCI (0.17 g, 0.90 mmol), HOBT (0.11 g, 0.77 mmol) in dichloromethane (25 ml) was stirred for 15 minutes in ice bath. A solution of amine in dichloromethane (25 ml) was added and followed by Et.sub.3N (0.09 g, 0.90 mmol), the reaction mixture was stirred for further 16 hours. After completion of the reaction, the organic layer was successively washed with water (230 ml) and saturated brine (40 ml), dried over MgSO.sub.4 and concentrated under vacuum. After filtration, the solvent was evaporated. The residue was then purified by column chromatography on silica gel using ethyl acetate and petroleum ether (60-90 C.) with 1:4 of v/v as an eluent to give a white solid IV in a 95% yield. The yields, physical properties, .sup.1H NMR data of the compounds IV are listed in Table 1.

EXAMPLE 5

General Procedure for the Synthesis of the Other Compound CL04-00

(5) ##STR00006##

(6) A solution of compounds b (1.10 mmol) in 15 ml ethanol was added to the solution of commercially available 1-(3-chloroisothiazol-5-yl)ethanone a (1.00 mmol) in ethanol (15 ml), and the reaction mixture was added the catalytic amount of hydrochloric acid (2 mol/L) and stirred at room temperature for overnight. The solvent was evaporated under reduced pressure and the residue was then purified by recrystallization in ethanol or column chromatography on silica gel using ethyl acetate and petroleum ether (b.p. 60-90 C.) with 1:4 of v/v as an eluent to obtain II in a 68.22% yield.

EXAMPLE 6

General Procedure for the Synthesis of the Other Compound CL05-00

(7) ##STR00007##

(8) In order to compare the difference activities between the compounds CL05-00 whose structure is closest to the structure of the compound in the present invention, the compound CL05-00 was synthesized according to the literature. The steps are described as follows:

(9) The reaction mixture of the compound A (1.00 mmol) in 15 ml DMF and CsCO.sub.3 (1.50 mmol) was stirred for 5 minutes. The compound B was added to a solution and was stirred at room temperature for 12 hours. The solvent was evaporated under reduced pressure and the residue was then purified by recrystallization in ethanol or column chromatography on silica gel using ethyl acetate and petroleum ether (b.p. 60-90 C.) with 1:8 of v/v as an eluent to obtain CL05-00 in a 55.57% yield.

EXAMPLE 7

Results of the Fungicide Activities of the Compounds IV

(10) It is worth noting that the compound CL04-00 reported in the patent WO 2000/003974 A1 is closest to the structure of the compound in the present invention. In order to compare the biological activity of the novel compound synthesized by the present invention, the present invention synthesizes the compound CL04-00.

(11) The results of the fungicide activities of the compounds IV at 50 g/mL are listed in Table 2. It showed that all compounds in the present invention have different potential of fungicidal activity. The compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22A, CL04-22D, CL04-25C, CL04-17, CL04-32A, CL04-32B, CL04-32C and CL04-32D showed over 30% inhibition against A. solani at 50 g/mL, which showed over 10% better inhibition than that of the compound CL04-00; and among them, the compounds CL03-50, CL04-03, CL04-04-A, CL04-06, CL04-15B, CL04-15C and CL04-32D showed over 10% better inhibition than that of the compound CL05-00, besides, the compounds CL04-04-A and CL04-15B showed more than 80% inhibition against A. solani, which showed over 10% and 30% higher inhibition than that of the positive controls azoxystrobin and kresoxim-methyl respectively; especially CL04-15B displayed the best fungicidal activity, up to 100%. The compounds CL03-49, CL03-50, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22A, CL04-22B, CL04-22C, CL04-22D, CL04-22E, CL04-25C, CL04-17, CL04-32A, CL04-32B, CL04-32C and CL04-32D showed over 30% inhibition against C. arachidicola at 50 g/mL, which over 10% better inhibition than that of the compound CL04-00; and among them, the compounds CL04-04-A, CL04-04-B, CL04-15B, CL04-15C, CL04-22D and CL04-32D showed more than 75% inhibition, which showed over 10% better inhibition than that of the compound CL05-00, and over 20% better than that of the positive controls azoxystrobin and kresoxim-methyl; and the compounds CL04-03 and CL04-15B exhibited 100% and 91.67%, respectively. The compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22A, CL04-22B, CL04-22C, CL04-22D, CL04-22E, CL04-22F, CL04-24, CL04-25A, CL04-25B, CL04-25C, CL04-25E, CL04-17, CL04-32A, CL04-32B, CL04-32C, CL04-32D and CL04-32F showed over 30% inhibition against G. zeae at 50 g/mL, which showed over 10% better inhibition than that of the compound CL04-00 and kresoxim-methyl; and among them, the compounds CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15B, CL04-15C, CL04-22A, CL04-22B, CL04-22C, CL04-22D, CL04-25B, CL04-25C, CL04-17, CL04-32B, CL04-32C and CL04-32F showed over 10% better inhibition than that of the compound CL05-00; and among them, CL04-15C, CL04-22B, CL04-22D, CL04-25C, CL04-32B and CL04-32D showed more than 80% inhibition, which showed over 10% better than that of the positive control azoxystrobin; especially the compounds CL04-22B, CL04-22D, CL04-25C and CL04-32D showed the best fungicidal activity, up to 100%. The compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22B, CL04-22C, CL04-22D, CL04-17, CL04-32B, CL04-32C and CL04-32D showed over 45% inhibition against P. piricola at 50 g/mL, which showed over 10% better inhibition than that of the compound CL04-00; and among them, the compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-06, CL04-15C, CL04-22D, CL04-32C showed more than 70% inhibition, which showed over 10% better inhibition than that of the compound CL05-00 and kresoxim-methyl; and the compound CL04-03 exhibited the best inhibition, up to 86.96%. The compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22A, CL04-22B, CL04-22C, CL04-22D, CL04-22E, CL04-22F, CL04-25C, CL04-17, CL04-32A, CL04-32B, CL04-32C and CL04-32D showed over 45% inhibition against B. cinerea at 50 g/mL, which showed over 10% better inhibition than that of the compound CL04-00; and among them, the compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22D and CL04-22E showed over 10% better inhibition than that of kresoxim-methyl; and the compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22D and CL04-17 showed 100% inhibition, which showed over 25% better inhibition than that of the compound CL05-00 and higher than azoxystrobin. The compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22A, CL04-22B, CL04-22C, CL04-22D, CL04-22F, CL04-25A, CL04-25B, CL04-25C, CL04-25D, CL04-25E, CL04-17, CL04-32A, CL04-32B, CL04-32C, CL04-32D and CL04-32F showed over 40% inhibition against S. sclerotiorum at 50 g/mL, which showed over 10% better inhibition than that of the compound CL04-00; and among them, the compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22A, CL04-22B, CL04-22C, CL04-22D, CL04-25C, CL04-17, CL04-32B, CL04-32C and CL04-32D showed over 10% better inhibition than that of kresoxim-methyl; besides, the compounds CL04-03, CL04-04-A, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22B, CL04-22D showed over 90% inhibition, which showed over 20% better inhibition than that of the compound CL05-00 and higher than azoxystrobin; especially CL04-03, CL04-06, CL04-15A, CL04-22B, CL04-22D showed the best fungicidal activity, up to 100%. The compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22A, CL04-22B, CL04-22C, CL04-22D, CL04-22E, CL04-22F, CL04-24, CL04-25A, CL04-25B, CL04-25C, CL04-25E, CL04-17, CL04-32A, CL04-32B, CL04-32C, CL04-32D and CL04-32F showed over 50% inhibition against R. cerealis at 50 g/mL, which showed over 40% better inhibition than that of the compound CL04-00; and among them, the compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-06, CL04-15B, CL04-22D, CL04-25C and CL04-32B showed over 90% inhibition, which showed over 10% better inhibition than that of the compound CL05-00 and azoxystrobin, and over 20% higher inhibition than that of kresoxim-methyl. The compounds CL03-49, CL03-50, CL04-03, CL04-04-A and CL04-06 showed the best fungicidal activity, up to 100%. The compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22B, CL04-22C, CL04-22B, CL04-25A, CL04-25C, CL04-17, CL04-32A, CL04-32B, CL04-32C and CL04-32D showed over 35% inhibition against P. sasakii at 50 g/mL, which showed over 10% better inhibition than that of the compound CL04-00; and among them, the compounds CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22B, CL04-22D, CL04-25C, CL04-32B, CL04-32C and CL04-32D showed over 10% better inhibition than that of the compound CL05-00 and kresoxim-methyl; besides the compounds CL04-22D, CL04-25C and CL04-32D showed over 80% inhibition, which showed better inhibition than that of azoxystrobin. The compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22A, CL04-22B, CL04-22C, CL04-22D, CL04-25A, CL04-25C, CL04-17, CL04-32A, CL04-32B, CL04-32C and CL04-32D showed over 40% inhibition against P. infestans (Mont.) de Bary at 50 g/mL, which showed over 10% better inhibition than that of the compound CL04-00 and kresoxim-methyl, and among them, the compounds CL04-03, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22A, CL04-22B, CL04-22C, CL04-22D, CL04-25A, CL04-25C, CL04-32A, CL04-32B, CL04-32C and CL04-32D showed over 55% inhibition, which showed over 10% better inhibition than that of azoxystrobin; besides, the compounds CL04-15B, CL04-15C, CL04-22C, CL04-22D, CL04-25A, CL04-25C, CL04-32A, CL04-32B, CL04-32C and CL04-32D showed over 86% inhibition, which showed over 10% better inhibition than that of the compound CL05-00; especially the compounds CL04-22C, CL04-22D, CL04-25A, CL04-25C, CL04-32B, CL04-32C and CL04-32D showed the best fungicidal activity, up to 100%. In summary, the compounds CL04-03, CL04-15B, CL04-15C and CL04-22D showed broad spectrum of fungicidal activities.

EXAMPLE 8

Fungicidal Efficacy of the Compounds IV in the Present Invention Against Sphaerotheca fuliginea

(12) Fungicidal efficacy of the active compound in field was carried out in the present invention. The name and code of the selected control object was Sphaerotheca fuliginea. is Jinyou 40 cucumber was selected as test crop variety. Application method and water consumption (L/ha): Spraying is applied before or at the onset of the disease. Spray the plants evenly with a dose of 675 L/hm.sup.2, and spray the same amount of water as a blank control. The results are listed in Table 3, and it showed that fungicidal efficacy of a 9.60% EC of CL04-22D against S. fuliginea was 78.62%; while efficacy of 250 g/L azoxystrobin SC and 250 g/L pyraclostrobin EC were 70.19% and 68.02%, respectively. The structure of trifloxystrobin is closest to the structure of the compound in the present invention, and efficacy of CL04-22D displayed over 10% higher than this positive control. By using analysis of variance and multiple comparisons, 9.60% CL04-22D EC showed significantly better efficacy against S. fuliginea than 250 g/L azoxystrobin SC and 50% trifloxystrobin WG at an application dosage of 37.5 g ai/ha. During the test, every treatment of 9.60% CL04-22D EC have no adverse effects on cucumbers. In summary, 9.60% CL04-22D EC showed good efficacy against S. fuliginea on cucumber.

EXAMPLE 9

Fungicidal Efficacy of the Compounds IV in the Present Invention Against Pseudoperonspera cubensis

(13) Fungicidal efficacy of active compound in field was carried out in the present invention. The name and code of the selected control object was Pseudoperonspera cubensis. Jinyou 3 cucumber was selected as test crop variety. Application method and water consumption (L/ha): Spraying is applied before or at the onset of the disease. Spray the plants evenly with a dose of 675 L/hm.sup.2, and spray the same amount of water as a blank control. The results are listed in Table 4, and it showed that fungicidal efficacy of a 9.60% EC of CL04-22D against P. cubensis was 79.18%; which showed 5% efficacy higher than 50% trifloxystrobin WG (72.02%); and was similar to 250 g/L pyraclostrobin EC (77.52%). By using analysis of variance and multiple comparisons, 9.60% CL04-22D EC showed similar efficacy against P. cubensis to 250 g/L pyraclostrobin EC and significantly better efficacy 50% trifloxystrobin WG at an application dosage of 75 g ai/ha. During the test, every treatment of 9.60% CL04-22D EC have no adverse effects on cucumbers. In summary, 9.60% CL04-22D EC showed good efficacy against P. cubensis on cucumber.

EXAMPLE 10

General Procedure for Systemic Acquired Resistance Screening of the Compounds IV

(14) The results of activity screening against TMV are listed in Table 5, and it indicated that most compounds showed a certain degree of direct inhibition activities against TMV at 100 g/mL. In curative mode, the compounds CL03-49, CL04-50, CL04-03, CL04-25A, CL04-25D, CL04-17, CL04-32B and CL04-32F had over 30% inhibition activities against TMV; among them, the compounds CL03-49, CL04-50, CL04-03, CL04-25A, CL04-32B and CL04-32F showed over 10% inhibition higher than that of the compounds CL04-00, CL05-00 and Isotianil; and the compounds CL04-25A, CL04-32B and CL04-32F had over 60% inhibition against TMV, especially the compounds CL04-25A and CL04-32B showed higher inhibition against TMV than Ningnanmycin. In inactivation mode, the compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-15A, CL04-15B, CL04-15C, CL04-22A, CL04-22B, CL04-22E, CL04-17, CL04-32A, CL04-32B, CL04-32C and CL04-32D had over 30% inhibition activities against TMV, which showed over 10% inhibition higher than that of the compounds CL04-00, CL05-00 and Isotianil; especially the compounds CL03-50, CL04-04-A and CL04-32B had over 70% inhibition against TMV, which were similar to Ribavirin. And the compound CL04-03 showed the best inactivation inhibition, up to 80%. In protection mode, the compounds CL03-50, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-22B, CL04-22D, CL04-25A, CL04-25C, CL04-32A, CL04-32E and CL04-32F had over 40% inhibition against TMV, which showed over 10% inhibition higher than that of the compounds CL04-00, CL05-00 and Isotianil; among them, the compounds CL03-50, CL04-04-A, CL04-06, CL04-22B, CL04-25C and CL04-32F had over 50% inhibition against TMV. In induction mode, the compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-04-B, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22A, CL04-22B, CL04-22C, CL04-22D, CL04-22F, CL04-24, CL04-25A, CL04-25C, CL04-17, CL04-32A, CL04-32B, CL04-32D and CL04-32F had over 30% inhibition against TMV, which showed over 10% inhibition higher than that of the compounds CL04-00 and CL05-00; among them, the compounds CL03-49, CL03-50, CL04-03, CL04-04-A, CL04-06, CL04-15A, CL04-15B, CL04-15C, CL04-22C, CL04-22D, CL04-25A, CL04-32B, CL04-32E had over 70% inhibition against TMV, especially the compounds CL03-50, CL04-15C, CL04-22C had over 80% induction inhibition against TMV, which showed higher inhibition than that of TDL, BTH, SZG-7 and Isotianil. In inactivation mode, the above compounds showed good inactivation activity. In summary, the compounds CL04-04-A and CL04-32B showed good inhibition against TMV. The most compounds in the present invention had good inhibition against TMV.

(15) The isothiazole oxime ether strobilurins derivatives IV of the present invention is also resistant to rice dwarf disease, yellow dwarf disease, stripe leaf blight, tomato fern leaf virus disease, pepper mosaic virus disease, tobacco vein necrosis virus, corn Dwarf mosaic disease, cauliflower mosaic virus, citrus virus disease, broccoli virus disease, Jianlan ring spot virus agriculture and forestry, and horticultural plant virus diseases have good antiviral activity.

EXAMPLE 11

The Use of the Isothiazole Oxime Ether-Containing Strobilurin Derivatives IV of the Present Invention in Combination with an Insecticide for Controlling Agricultural and Forestry and Horticultural Plant Pests

(16) The isothiazole oxime ether-containing strobilurin derivatives IV of this invention is combined with one, two or more insecticides to form an insecticidal composition for agricultural, forestry and horticultural plant pests controlling. The insecticides are chosen from Chlorpyrifos, Diazinon, Acetamiprid, Emamectin, Milbemectin, Abamectin, Spinosad, Fenvalerate, S-fenvalerate, -Cypermethrin, -Cypermethrin, Cyhalothrin, Deltamethrin, -Cyfluthrin, -Cyhalothrin, Permethrin, S-Bioallethrin, Bifenthrin, Ethofenprox, Tau-fluvalinate, Imidacloprid, Nitenpyram, Imidaclothiz, Thiacloprid, Thiamethoxam, Clothianidin, Dinotefuran, Diflubenzuron, chlorbenzuron, Teflubenzuron, Hexaflumuron, Flufenoxuron, Chlorfluazuron, Lufenuron, Penfluoron, Noviflumuron (CAS: 121451-02-3), Flucycloxuron, Novaluron, Bay sir 6874, Bay SIR-8514, N-[[5-(4-bromophenyl)-6-methyl pyrazin-2-yl]carbamoyl]-2-chlorobenzamide, Bistrifluron, (CAS: 467427-81-1), Tebufenozide, Halofenozide, Methoxyfenozide, Chromafenozide, Dimethoate, O,O-Dimethyl-S-methyl carbamoylmethyl phosphorothioate, Dichlorvos, Orthene, Triazophos, Quinalphos, Pyridaphenthion, Isazophos, Isoprocarb, Carbaryl, Pirimicarb, Metolcarb, Cartap, Fenobucarb, N-methyl-2,3-dimethylphenyl carbamate, Benfuracarb, Carbosulfan, Bromopropylate, Hexythiazox, Fenpyroximate, Pyridaben, Clofentezine, Propargite, Diafenthiuron, Pymetrozine, Spirodiclofen, Spirotetramatr, flufiprole, Azocyclotin, Buprofezin, Mocap, Fipronil, Molosultap, Chloantraniliprole, Flubendiamide, Cyhalodiamide, Cyantraniliprole, Tolfenpyrad, Chlorfenapyr, Etoxazole, 4-Chloro-N-(4-tert-butyl benzyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide (CAS: 119168-77-3), Tebufenpyrad, 4-chloro-5-[(6-chloropyridin-3-yl)methoxy]-2-(3,4-dichlorophenyl)pyridazin-3-one (CAS: 107360-34-9), and Pyriproxyfen. The isothiazole oxime ether-containing strobilurin derivatives IV is present in the insecticidal composition in an amount between 1%-90% by mass percentage. The mass ratio of the isothiazole oxime ether-containing strobilurin derivatives IV to the above-described insecticide is from 1%:99% to 99%:1%. The plant pests controlled by the insecticidal composition are chosen from Tetranychus cinnbarinus, Locusta migratoria manilensis, cypress locust, rice blast, Japanese yellow ridge, single locust, oriental carp, rice locust, scorpion horse, greenhouse hummer, rice tube hummer, wheat tube hummer, greenhouse whitefly, whitefly, black-tailed leafhopper, big green leafhopper, cotton leafhopper, spotted wax hopper, brown plant hopper, white-backed plant hopper, gray plant hopper, sugarcane, squared cornucopia, cotton aphid, wheat fork, wheat long tube, sorghum, radish, blown sorghum, mulberry scorpion, scorpion shield, pear round scorpion, white wax worm, red wax scorpion, Korean ball scorpion, stephanitis nashi esaki et takeya, banana nets, fine-horned flower buds, tiny flower buds, needle-edge mites, rice spider mites, rice brown mites, rice black mites, rice green mites, green blind mites, ticks, black scorpions, large grass mites, licao, chinese grasshopper, moth, yellow moth, brown moth, flat moth, wheat moth, cotton bollworm, sweet potato moth, diamondback moth, peach small heartworm, soybean heartworm, peach small carnivorous worm, apple leaf roller moth, brown leaf moth, yellow leaf moth, sorghum, pea pod, corn borer, stem borer, rapeseed meal, rice leaf roller, stripe, roller leafhopper, armyworm, Spodoptera litura, cotton small bridge worm, beet armyworm, giant salamander, dingdian diamond, small tiger, earth tiger, yellow tiger, toxic moth, gypsy moth, sweet potato hawk moth, bean hawk moth, straight grain rice butterfly, cryptic valley butterfly, citrus phoenix butterfly, jade belt phoenix butterfly, cabbage butterfly, ramie red butterfly, ramie butterfly, bean phthalocyanine, venus carapace, wrinkle-skinned armor, wheat-spotted armor, ditch-gold needle, fine-necked Golden Needle, G. striata, Black-skinned scorpion, citrus small jiding, lampra limbata gebler, Tenebrio molitor, Black mealworm, tribolium castaneum herbst, Tribolium confusum jac. du val., patina, golden tortoise, dark golden tortoise, north China black scorpion golden tortoise, mulberry ox, star celestial, orange brown hornbill, peach red neck horn, big worm leaf worm, small cockroach leaf worm, yellow squash, yellow scalloped beetle, mung bean elephant, pea elephant, broad bean elephant, corn elephant, rice elephant, Dolerus Chu, pear fruit sawfly, yellow belt wasp, armyworm white star wasp, Chrysalis suspense, Campoletis chlorideae Uchida, Verruca verruca, mosquito, fly, horsefly, wheat blossom midge, wheat midge, rice gall midge, Tetradacus citri, melon fruit fly, wheat fly ash, Leafminer, soybean stem borer, wheat straw flies, seed fly, onion fly, carrot fly, Exorista civilis Rondani, and Mailing flies of corn borer. The plant controlled by the pesticidal composition is selected from the group consisting of rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, tapioca, soybean, pea, broad bean, mung bean, adzuki bean, cotton, sericulture, peanut, rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, rape, onions, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, banana, orchid, or bonsai.

EXAMPLE 12

The Use of the Isothiazole Oxime Ether-Containing Strobilurin Derivatives IV of the Present Invention in Combination with a Fungicide for Controlling Agricultural and Forestry and Horticultural Plant Diseases

(17) The isothiazole oxime ether-containing strobilurin derivatives IV of the present invention is combined with one, two or more fungicides to form a fungicidal composition for controlling agricultural and forestry and horticultural plant diseases. The above-described fungicides are chosen from Benzothiadiazole, Tiadinil, abbreviated as TDL, thiazamide, SZG-7, 4-methyl-1,2,3-thiadiazole-5-carboxylic acid, 4-methyl-1,2,3-thiadiazol-5-formate, 4-methyl-1,2,3-thiadiazole-5-carboxylic acid ethyl ester, DL--aminobutyric acid, isotianil, 3,4-dichloroisothiazol-5-carboxylic acid, 3,4-dichloroisothiazol-5-formate, 3,4-dichloroisothiazol-5-carboxylic acid ethyl ester, ribavirin, Antofine, Ningnanmycin or salicylic acid, cymoxanil, thiram, Zinc bis dimethyldithiocarbamate, mancozeb, ethylphosphorus, Thiophanate-methyl, chlorothalonil, Fenaminosulf, procymidone, fenpropidin, Thiophanate-methyl, thiophanate, Metalaxyl-M, flumorph, Dimethomorph, benalaxylM, diclocymet, flusulfamide, TF-991, thifluzamide, flutolanil, tecloftalam, carpropamid, cyflufenamid, fenhexamide, fenoxanil, silthiopham, furametpyr, penthiopyrad, mandipropamid, zoxamide, fenfuram, carboxin, chlozolinate, iprodione, procymidone, azoxystrobin, dimoxystrobin, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin, pyraclostrobin, trifloxystrobin, enestroburin, SYP-1620, Azaconazole, bromuconazole, cyproconazole, difenoconazole, diniconazole, diniconazoleM, epoxiconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, simeconazole, tebuconazole, tetraconazole, triadimenol, triticonazole, bitertanol, thiabendazole, fuberidazole, imazalil, S-imazalil, prochloraz, triflumizole, cyazofamid, fenamidone, oxpoconazole, pefurazoate, famoxadone, SYPZ048, hymexazol, oxadixyl, ethaboxam, etridiazole, octhilinone, benthiazole, dodemorph, fenpropimorph, tridemorph, fenpiclonil, fludioxonil, fluazinam, pyrifenox, ICIA0858, boscalid, fluopicolide, PEIP, cyprodinil, diflumetorim, ferimzone, mepanipyrim, pyrimethanil, fenarimol, nuarimol, chinomethionat, dithianon, ethoxyquin, 8 hydroxyquinoline, sulfate, proquinazid, quinoxyfen, diethofencarb, iprovalicarb, benthiavalicarb, Isopropyl, propamocarb, methasulfocarb, edifenphos, iprobenfos, pyrazophos, tolclofosmethyl, S-blasticidin, Kasugamycin, myxothiazol, polyoxins, olyoxorim, pseudomycin, PSFD271, validamycin, jinggangmycin, streptomycin, metalaxyl, furalaxyl, benalaxyl, ofurace, mepronil, carbendazim, benomyl, thiophanate-methyl, triadimefon, bupirimate, dimethirimol, ethirimol, captafol, captan, folpet, vinclozolin, fluoroimide, dimethachlon, isoprothiolane, EBP, bismerthiazol, quintozene, propineb, fosetylaluminium, sulfur, Bordeaux-mixture, copper-sulphate, copper-oxychloride, cuprous-oxide, copper-hydroxide, acibenzolar, metrafenone, pencycuron, bethoxazin, diclomezine, fenpropidin, Phthalide, pyroquilon, spiroxamine, tricyclazole, triforine, cymoxanil, dodine, guazatine, iminoctadine, GY81330, NKI42650330, dicloran, dichlofluanid, tolylfluanid, zopfiellin, OK9601, fenaminosulf, oxolinic-acid, probenazole, bronopol, benclothiaz, methyl-bromide, methyl-iodide, metam, methyl-isothiocyanate, dazomet, DCIP, fosthiazate, cadusafos, fensulfothion, thionazin, fenamiphos, ethoprophos, dichlofenthion, isazofos, fosthietan, oxamyl, aldicarb, carbofuran, sulfuryl-fluoride, 1,3-dichloropropene, methyl 2,5-dichloroisonicotinate, or oryzaemate.

(18) The isothiazole oxime ether-containing strobilurin derivatives IV is present in the fungicidal composition in an amount between 1%-90% by mass percentage. The mass ratio of the isothiazole oxime ether-containing strobilurin derivatives IV to the above-described fungicide is from 1%:99% to 99%:1%. The formulation processed by the fungicidal composition is chosen from suspension concentrates for seed treatment, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, block bait, granular bait, flake bait, concentrated bait, slow release block, electrostatic spray formulation, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, hot spray formulation, cold spray formulation, aerosol, solid liquid mixing agent, liquid/liquid mixing agent, solid/solid mixing agent, lacquer, granule, tracking powder, oil suspension, oil dispersible powder, thickener, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra-low volume liquid agent, or steam release agent. The plant disease controlled by the fungicidal composition is selected from the group consisting of rice seedling cotton rot, tomato root rot, potato late blight, tobacco black shank, millet powdery mildew, grape downy mildew, lettuce downy mildew, cucumber Downy mildew, and cucumber anthracnose. The plant controlled by the fungicidal composition is chosen from rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, cassava, soybean, pea, broad bean, mung bean, adzuki bean, cotton, sericulture, peanut, rape, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, onion, garlic, watermelon, melon, cantaloupe, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, banana, papaya, orchid, or bonsai.

EXAMPLE 13

The Use of the Isothiazole Oxime Ether-Containing Strobilurin Derivatives IV of the Present Invention in Combination with an Anti-Plant Virus Agent for Controlling Agricultural and Forestry and Horticultural Plant Diseases

(19) The isothiazole oxime ether-containing strobilurin derivatives IV can be used alone or can be mixed with one, two or more antiviral agents to form an antiviral mixture for controlling agricultural and forestry and horticultural plant virus diseases. The above-described antiviral agents are chosen from Benzothiadiazole, Tiadinil, abbreviated as TDL, thiazamide, SZG-7, 4-methyl-1,2,3-thiadiazole-5-carboxylic acid, 4-methyl-1,2,3-thiadiazol-5-formate, 4-methyl-1,2,3-thiadiazole-5-carboxylic acid ethyl ester, DL--aminobutyric acid, isotianil, 3,4-dichloroisothiazol-5-carboxylic acid, 3,4-dichloroisothiazol-5-formate, 3,4-dichloroisothiazol-5-carboxylic acid ethyl ester, ribavirin, Antofine, Ningnanmycin or salicylic acid, Cytosinpeptidemycin, methyl 2,5-dichloroisonicotinate, Oryzaemate, Validoxylamine A, or Validamycin. The isothiazole oxime ether-containing strobilurin derivatives IV is present in the antiviral composition in an amount between 1%-90% by mass percentage. The mass ratio of the isothiazole oxime ether-containing strobilurin derivatives IV to the above-described antiviral agents is from 1%:99% to 99%:1%. The formulation processed by the antiviral composition is chosen from suspension concentrates for seed treatment, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, block bait, granular bait, flake bait, concentrated bait, slow release block, electrostatic spray formulation, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, hot spray formulation, cold spray formulation, aerosol, solid liquid mixing agent, liquid/liquid mixing agent, solid/solid mixing agent, lacquer, granule, tracking powder, oil suspension, oil dispersible powder, thickener, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra-low volume liquid agent, or steam release agent. The plants viral diseases controlled by the antiviral composition are chosen from rice dwarf disease, yellow dwarf disease, stripe leaf blight, tomato fern leaf virus disease, pepper mosaic virus disease, tobacco vein necrosis virus disease, corn dwarf mosaic disease, cauliflower mosaic virus, citrus virus disease, orchid leaf virus, or Jianlan ring spot virus. The plants controlled by the antiviral composition are chosen from rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, cassava, soybean, pea, broad bean, mung bean, adzuki bean, cotton, sericulture, peanuts, rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, radish, cucumber, cabbage, celery, mustard, beet, rape, onion, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, orchid, or bonsai.

EXAMPLE 14

The Use of the Isothiazole Oxime Ether-Containing Strobilurin Derivatives IV of the Present Invention in Combination with an Acaricide for Controlling Agricultural and Forestry and Horticultural Plant Damage

(20) The isothiazole oxime ether-containing strobilurin derivatives IV can be used alone or can be mixed with one, two or more acaricides to form an acaricide composition for controlling agricultural and forestry and horticultural plant diseases. The above-described acaricides are chosen from Azocyclotin, Cyhexatin, Fenbutatin oxide, Triphosphorustin, Chlorfenvinphos, Dimethylvinphos, Crotoxyphos, Dichlorvos, Heptenophos, Mevinphos, Monocrotophos, Dibrom, Chlorpyrifos, Pirimiphos ethyl, Dialifos, O,O-Dimethyl-S-methylcarbamoylmethyl phosphorothioate, Dioxathion, Ethion, Malathion, Methacrifos, Phosalone, Phoxim, Pirimiphos-methyl, Quinalphos, Sulfotep, Triazophos, Vamidothion, Isocarbophos, Methamidophos, Popetamphos, Phosmet, Arinathrin, Bifenthrin, Cyhalothrin, Gamma-Cyhalothrin, Fenpropathrin, Flucythrinate, Flumethrin, Tau-fluvalinate, brofluthrinate, Bifenazate, Fenothiocarb, Aldicarb, Butocarboxim, Oxamyl, Thiocarbonime, Thiofanox, Benomyl, Banol, Carbofuran, Carbosulfan, Metolcarb, promacyl, formetanate, N-2,4-dimethylphenyl-N-methylformamidine, Chlordimeform, Amitraz, Benzyl benzoate, Bromopropylate, Cyflumetofen, Acequinocyl, Flufenoxuron, liuyangmycin, piericidin, -exotoxin, tetranactin, Abamectin, Doramectin, Eprinomectin, Ivermectin, Selamectin, Moxidectin, pyrethrins, Nicotine, Matrine, Azadirachtin, rotenone, Tebufenpyrad, Pyridaben, Fenpyroximate, clofentezine, Propargite, Hexythiazox, Spirodiclofen, Fluacrypyrim, Ovex, or Pyridaben. The isothiazole oxime ether-containing strobilurin derivatives IV is present in the acaricidal composition in an amount between 1%-90% by mass percentage. The mass ratio of the isothiazole oxime ether-containing strobilurin derivatives IV to the above-described acaricidal agents is from 1%:99% to 99%:1%. The formulation processed by the acaricidal composition is chosen from suspension concentrates for seed treatment, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, block bait, granular bait, flake bait, concentrated bait, slow release block, electrostatic spray formulation, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, hot spray formulation, cold spray formulation, aerosol, solid liquid mixing agent, liquid/liquid mixing agent, solid/solid mixing agent, lacquer, granule, tracking powder, oil suspension, oil dispersible powder, thickener, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra-low volume liquid agent, or steam release agent. The insects controlled by the acaricidal composition are chosen from the genus Aphididae, the genus Diptera, the eucalyptus, the genus Eucalyptus, and the mites, world agricultural pests, forest pests, horticultural pests and health hazards. The plants controlled the acaricidal composition are chosen from rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, tapioca, soybean, pea, broad bean, mung bean, adzuki bean, cotton, sericulture, peanuts, rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, rape, onion, garlic, watermelon, melon, cantaloupe, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, banana, papaya, orchid, or bonsai.

(21) TABLE-US-00001 TABLE 1 Structure and physical and chemical parameters of the isothiazole oxime ether-containing strobilurin derivatives IV of the present invention Num- .sup.1HNMR(CDCl.sub.3, ber Name Structure m.p./ C. 400 MHz, ppm) Yield % Shape 1 CL03-49 100-102 7.53(s, 1H, CCH), 7.42- 7.36(m, 1H, PhH), 7.31- 7.23(m, 2H, PhH), 7.13- 7.07(m, 1H, PhH), 5.20 (s, 2H, PhCH.sub.2), 3.72(s, OCH.sub.3), 3.59(s, OCH.sub.3), 2.45(s, CCH.sub.3) 59.14% Yellow crystal 2 CL03-50 61-63 8.10(s, 1H, OCH), 7.54 (s, 1H CCH), 7.39 (dd, J = 5.4, 3.6 Hz, PhH), 7.28(dd, J = 5.7, 3.4 Hz, 2H, PhH), 7.11(dd, J = 5.4, 3.5 Hz, 1H, PhH), 5.08(s, 2H, PhCH.sub.2), 3.77 (s, 3H, OCH.sub.3), 3.63(s, 3H, OCH.sub.3) 56.82% Yellow crystal 3 CL04-03 0 105-107 7.61(s, 1H, CCHO), 7.48(dd, J = 8.3, 4.9 Hz, 1H, PhH), 7.37(dd, J = 5.3, 3.8 Hz, 2H, PhH), 7.22-7.18(m, 1H, PhH), 5.29(s, 2H, NH.sub.2), 5.02(s, 2H, PhCH.sub.2), 3.84(s, 3H, OCH.sub.3), 3.73(s, 3H, OCH.sub.3) 97.83% Yellow solid 4 CL04-04-A 36-38 7.51(s, 1H, CCHO), 7.33(dd, J = 5.9, 3.1 Hz, 1H, PhH), 7.29-7.24 (m, 2H, PhH), 7.12- 7.06(m, 1H, PhH), 5.22(ddd, J = 9.0, 3.7, 2.7 Hz, OCH), 4.94 (s, 1H, PhCH.sub.2) 3.78- 3.73(s, 3H, OCH.sub.3), 3.62(s, 3H, OCH.sub.3), 2.73(dd, J = 16.9, 2.4 Hz, 1H, NCCH.sub.2), 2.42(dd, J = 16.8, 9.1 92.11% Light Yellow solid Hz, 1H, NCCH.sub.2), 1.81(s, 3H, NCCH.sub.3) 5 CL04-04-B 103-105 11.74(s, 1H, OCCH.sub.2), 7.53(s, 1H, CCHO), 7.36(m, 1H, PhH), 7.33 7.23(m, 2H, PhH), 7.11 (m, 2H, PhH), 5.92(s, 1H, OCCH.sub.2), 4.98 (s, 2H, PhCH.sub.2), 3.77 (s, 3H, OCH.sub.3), 3.63 (s, 3H, OCH.sub.3), 2.00 (s, 3H, NCCH.sub.3) 47.62% Yellow solid 6 CL04-06 101-103 7.57(s, 1H, CCHO), 7.45(dd, J = 7.3, 4.5 Hz, 2H, CHCH, PhH), 7.35-7.31(m, 2H, PhH), 7.19-7.15(m, 1H, PhH), 6.88(d, J = 16.7 Hz, 1H, CHCH), 5.09(s, 2H, PhCH.sub.2), 3.81(s, 3H, OCH.sub.3), 3.67(s, 3H, OCH.sub.3), 2.11(s, 3H, 40.00% White solid NCCH.sub.3) 7 CL04-15A 73-75 7.51(s, 1H, PhH), 7.47-7.43(m, 2H, PhH), 7.24-7.20 (m, 1H, PhH), 5.23 (s, 2H, PhCH.sub.2), 4.06 (s, 3H, OCH.sub.3), 3.83 (s, 3H, OCH.sub.3), 2.52 (s, 3H, NCCH.sub.3) 71.43% Light yellow power 8 CL04-15B 88-90 7.74(s, 1H, NCH), 7.42(s, 1H, PhH), 7.37(dd, J = 6.9, 2.9 Hz, 2H, PhH), 7.15-7.12 (m, 1H, PhH), 5.22(s, 2H, PhCH.sub.2), 3.96(s, 3H, OCH.sub.3), 3.72(s, 3H, OCH.sub.3) 72.73% Light yellow power 9 CL04-15C 104-106 7.40-7.30(m, 3H, PhH), 7.13(d, J = 6.4 Hz, 1H, PhH), 5.18(s, 2H, NH.sub.2), 4.91 (s, 2H, PhCH.sub.2), 3.97 (s, 3H, OCH.sub.3), 3.79 (s, 3H, OCH.sub.3) 42.96% Brownish yellow crystal 10 CL04-22A 78-80 7.57-7.39(m, 3H, PhH), 7.22(dd, J = 6.7, 1.9 Hz, 1H, PhH), 7.11(s, 1H, PhH), 5.91(tdd, J = 55.9, 8.6, 4.3 Hz, 1H, CHF.sub.2), 5.18(d, J = 38.8 Hz, 2H, PhCH.sub.2), 4.00(d, J = 13.8 Hz, 3H, OCH.sub.3), 3.83-3.65(m, 2H, NCH.sub.2), 2.42(d, 95.00% White crystal J = 72.2 Hz, 3H, NCCH.sub.3) 11 CL04-22B 120-122 7.50(s, 1H, PhH), 7.44(dd, J = 9.6, 5.3 Hz, 2H, PhH), 7.22 (d, J = 6.8 Hz, 1H, PhH), 6.99(s, 1H, OCNH), 5.24(s, 2H, PhCH.sub.2), 4.14(d, J = 5.2 Hz, 2H, NCH.sub.2), 3.98(s, 3H, OCH.sub.3), 2.42(d, J = 70.7 Hz, 3H, NCCH.sub.3), 2.29(d, J = 9.0 Hz, 1H, 95% White crystal CCH) 12 CL04-22C 115-117 7.50(d, J = 7.0 Hz, 1H, PhH), 7.42 (dt, J = 11.5, 8.0 Hz, 2H, PhH), 7.22(d, J = 6.7 Hz, 1H, PhH), 6.87(s, 1H, OCNH), 5.24(s, 2H,, PhCH.sub.2), 3.93(s, 3H, OCH.sub.3), 2.78 (d, J = 3.6 Hz, 1H, NCH), 2.51(s, 3H, NCCH.sub.3), 72.73% Colorless crystal 0.82(d, J = 6.3 Hz, 2H, cyclopropyl-CH.sub.2), 0.59 (s, 2H, cyclopropyl-CH.sub.2) 13 CL04-22D 0 79-81 7.52-7.44(m, 1H, PhH), 7.40(dd, J = 9.4, 5.8 Hz, 2H, PhH), 7.21(d, J = 7.2 Hz, 1H, PhH), 6.92(d, J = 4.5 Hz, 1H, OCNH), 5.25(s, 2H, PhCH.sub.2), 3.91(s, 3H, OCH.sub.3), 2.84(d, J = 4.9 Hz, 3H, NCH.sub.3), 2.48(s, 3H, 70.97% White solid NCCH.sub.3) 14 CL04-22E 7.47(d, J = 6.8 Hz, 1H, PhH), 7.44-7.38 (m, 2H, PhH), 7.23- 7.19(m, 1H, PhH), 6.93(s, 1H, OCNH), 5.15(s, 2H, PhCH.sub.2), 3.99(s, 3H, OCH.sub.3), 3.00(s, 2H, SCH.sub.2), 2.37(s, 3H, NCCH.sub.3), 2.19(s, 3H, SCH.sub.3), 1.49 (s, 6H, CH.sub.3CCH.sub.3) 36.84% Yellow oil 15 CL04-22F 35-37 7.44(dd, J = 7.2, 4.1 Hz, 1H, PhH), 7.42- 7.37(m, 2H, PhH), 7.20(d, J = 6.7 Hz, 1H, PhH), 6.88(d, J = 8.0 Hz, 1H, OCNH), 5.13(s, 2H, PhCH.sub.2), 4.24(dt, J = 13.4, 6.6 Hz, 1H, NCH), 3.98 (s, 3H, OCH.sub.3), 2.72 (dd, J = 13.5, 5.5 Hz, 1H, SCH.sub.2), 2.63(dd, J = 13.5, 6.4 Hz, 1H, 37.84% White power SCH.sub.2), 2.33(s, 3H, NCCH.sub.3), 2.15(s, 3H, SCH.sub.3), 1.32(d, J = 6.6 Hz, 3H, NCCH.sub.3) 16 CL04-24 118-120 7.37(s, 1H, PhH), 7.35-7.30(m, 2H, PhH), 7.13-7.08(m, 1H, PhH), 7.02(s, 1H, OCNH), 5.84 (tt, J = 55.9, 4.0 Hz, 1H, CHF.sub.2), 5.18(s, 2H, NH.sub.2), 4.88(s, 2H, PhCH.sub.2), 3.92(s, 3H, OCH.sub.3), 3.73- 3.60(m, 2H, NCH.sub.2) 76.60% Colorless crystal 17 CL04-25A 106-108 7.36(t, J = 3.6 Hz, 1H, PhH), 7.35-7.31(m, 2H, PhH), 7.10(dd, J = 5.8, 3.0 Hz, 1H, PhH), 6.92(s, 1H, OCNH), 5.21(s, 2H, NH.sub.2), 4.88(s, 2H, PhCH.sub.2), 4.08 (dd, J = 5.4, 2.5 Hz, 2H, NCH.sub.3), 3.91(s, 3H, OCH.sub.3), 2.17(t, J = 2.5 Hz, 1H, CCH) 71.43% White solid 18 CL04-25B 12-128 7.38-7.35(m, 1H, PhH), 7.34-7.30(m, 2H, PhH), 7.11-7.08 (m, 1H, PhH), 6.80 (s, 1H, OCNH), 5.27(s, 2H, NH.sub.2), 4.87 (s, 2H, PhCH.sub.2), 3.87 (s, 3H, OCH.sub.3), 2.77- 2.70(m, 1H, NCH), 0.73 (dd, J = 7.0, 5.4 Hz, 2H, 48.71% White power cyclopropyl-CH.sub.2), 0.55- 0.50(m, 2H, cyclopropyl-CH.sub.2) 19 CL04-25C 122-124 7.37(d, J = 5.7 Hz, 1H, PhH), 7.32(dd, J = 6.0, 3.1 Hz, 2H, PhH), 7.12-7.08(m, 1H, PhH), 6.73(d, J = 3.8 Hz, 1H, OCNH), 5.25(s, 2H, NH.sub.2), 4.88(s, 2H, PhCH.sub.2), 3.88(s, 3H, OCH.sub.3), 2.84(d, J = 5.0 Hz, 3H, NCH.sub.3) 39.39% White power 20 CL04-25D 28-30 7.44(dd, J = 5.9, 3.3 Hz, 1H, PhH), 7.40- 7.36(m, 2H, PhH), 7.16(dd, J = 5.6, 3.3 Hz, 1H, PhH), 6.91 (s, 1H, OCNH), 5.35(s, 2H, NH.sub.2), 4.96 (s, 2H, PhCH.sub.2), 3.96 (s, 3H, OCH.sub.3), 2.98 (s, 2H, S CH.sub.2), 2.16 (s, 3H, SCH.sub.3), 1.46 (s, 6H, CH.sub.3CCH.sub.3) 58.06% Yellow- trans- parent crystal 21 CL04-25E 7.44(dd, J = 3.9, 1.9 Hz, 1H, PhH), 7.41- 7.38(m, 2H, PhH), 7.20-7.16(m, 1H, PhH), 6.91(d, J = 8.2 Hz, 1H, OCNH), 5.34(s, 2H, NH.sub.2), 4.96(s, 2H, PhCH.sub.2), 4.29-4.21(m, 1H, NCH), 3.97(s, 3H, OCH.sub.3), 2.73(dd, J = 13.5, 5.5 Hz, 1H, SCH.sub.2), 2.64(dd, J = 13.5, 6.4 Hz, 1H, 44.19% Yellow oil SCH.sub.2), 2.15(s, 3H, SCH.sub.3), 1.32(d, J = 6.6 Hz, 3H, NCHCH.sub.3) 22 CL04-17 105-107 7.35(ddd, J = 9.6, 6.1, 2.0 Hz, 3H, PhH), 7.14-7.11 (m, 1H, PhH), 6.75 (d, J = 5.1 Hz, 2H, CHCH), 5.02(s, 2H, PhCH.sub.2), 3.97(s, 3H, OCH.sub.3), 3.79(s, 3H, NCH.sub.3), 1.97(s, 3H, CCCH.sub.3) 60.00% white power 23 CL04-32A 0 98-100 7.47-7.36(m, 4H, CHCH, PhH), 7.21-7.16(m, 1H, PhH), 7.07(d, J = 5.8 Hz, 1H, OCNH), 6.87 (d, J = 16.7 Hz, 1H, CHCH), 5.86(tt, J = 55.9, 4.1 Hz, 1H, CHF.sub.2), 5.05(s, 2H, PhCH.sub.2), 3.97(s, 53.57% White solid 3H, OCH.sub.3), 3.80- 3.63(m, 2H, NCH.sub.2), 2.09(s, 3H, NCCH.sub.3) 24 CL04-32B 92-93 7.47-7.35(m, 4H, CHCH, PhH), 7.21- 7.17(m, 1H, PhH), 7.00-6.91(m, 1H, OCNH), 6.82(d, J = 3.7 Hz, 1H, CHCH), 5.05(s, 2H, PhCH.sub.2), 4.17(s, 1H, NCH.sub.2), 4.12-4.09(m, 1H, NCH.sub.2), 3.97(s, 3H, OCH.sub.3), 2.26(dt, J = 6.8, 2.6 Hz, 1H, CCH), 62.96% White solid 2.05(s, 3H, NCCH.sub.3) 25 CL04-32C 95-97 7.50-7.36(m, 4H, CHCH, PhH), 7.22 (d, J = 6.9 Hz, 1H, PhH), 6.86(t, J = 6.0 Hz, 2H, OCNH, CHCH), 5.11(s, 2H, PhCH.sub.2), 3.97(s, 3H, OCH.sub.3), 2.07(s, 3H, NCCH.sub.3), 0.84(d, J = 5.6 Hz, 2H, 59.26% White power cyclopropyl-CH.sub.2), 0.62 (dd, J = 3.7, 1.7 Hz, 2H, cyclopropyl-CH.sub.2) 26 CL04-32D 137-139 7.48-7.35(m, 4H, CHCH, PhH), 7.21-7.16(m, 1H, PhH), 6.81(d, J = 3.7 Hz, 1H, CHCH), 6.77(s, 1H, OCNH), 5.09(s, 2H, PhCH.sub.2), 3.96(s, 3H, OCH.sub.3), 2.93(d, J = 5.0 Hz, 3H, NCH.sub.3), 2.04(s, 3H, 65.38% trans- parent crystal NCCH.sub.3) 27 CL04-32E 7.47-7.34(m, 4H, CHCH, PhH), 7.18 (d, J = 7.3 Hz, 1H, PhH), 6.89(d, J = 2.9 Hz, 1H, OCNH), 6.83(s, 1H, CHCH), 5.09(d, J = 17.2 Hz, 2H, PhCH.sub.2), 3.97(s, 3H, OCH.sub.3), 2.98(s, 2H, SCH.sub.2), 2.16(s, 3H, 100% Yellow oil SCH.sub.3), 2.07(s, 3H, NCCH.sub.3), 1.47(s, 6H, CH.sub.3CCH.sub.3) 28 CL04-32F 7.41-7.26(m, 4H, CHCH, PhH), 7.12 (dd, J = 6.7, 2.0 Hz, 1H, PhH), 6.81(d, J = 4.5 Hz, 1H, OCHNH), 6.74(s, 1H, CHCH), 5.03(s, 2H, PhCH.sub.2), 4.16(dd, J = 13.3, 6.6 Hz, 1H, NCH), 3.89(s, 3H, 84.62% Yellow oil OCH.sub.3), 2.68-2.47(m, 2H, SCH.sub.2), 2.07(s, 3H, SCH.sub.3), 1.98(s, 3H, NCCH.sub.3), 1.24 (d, J = 6.7 Hz, 3H, NCCH.sub.3) 29 CL04-00 68.22% 30 CL04-00 111-113 7.70 (s, 1H, PhH), 7.51-7.36 (m, 5H, PhH), 7.20 (d, J = 7.2 Hz, 1H, PhH), 5.01 (s, 2H, PhCH.sub.2), 4.74 (s, 2H, NH.sub.2), 4.04 (s, 3H, OCH.sub.3), 3.84 (s, 3H, NCH.sub.3). 55.57% White crystal

(22) TABLE-US-00002 TABLE 2 Fungicidal activity of the isothiazole oxime ether-containing strobilurin derivatives IV of the present invention (50 g/mL, inhibition/%) Number Name AS CA GZ PP BC SS RC PS PI 1 CL03-49 42.86 66.67 52.17 78.26 100 80.00 100 64.71 52.63 2 CL03-50 57.14 66.67 73.91 78.26 100 53.33 100 64.71 57.89 3 CL04-03 57.14 100 60.87 86.96 100 100 100 58.82 47.37 4 CL04-04-A 85.71 75.00 60.87 73.91 100 90.00 100 52.94 42.11 5 CL04-04-B 50.00 75.00 73.91 60.87 58.33 76.67 92.59 64.71 52.63 6 CL04-06 57.14 50.00 73.91 73.91 100 100 100 70.59 78.95 7 CL04-15A 47.06 50.00 41.18 53.03 100 100 85.45 76.92 78.95 8 CL04-15B 100 91.67 70.59 62.12 100 90.00 98.18 69.23 94.74 9 CL04-15C 52.94 75.00 94.44 71.21 100 98.00 89.09 76.92 89.47 10 CL04-22A 37.14 42.86 78.95 40.35 53.85 84.00 87.70 20.00 80.00 11 CL04-22B 28.57 35.71 100 49.12 51.92 100 86.89 73.33 80.00 12 CL04-22C 27.87 44.00 63.64 61.40 47.37 80.00 60.98 56.76 100 13 CL04-22D 47.54 87.50 100 80.77 100 100 100 89.19 100 14 CL04-22E 27.27 45.83 51.52 42.86 62.50 29.41 76.00 21.21 28.57 15 CL04-22F 16.36 12.50 33.33 32.77 45.54 52.94 76.00 15.15 17.14 16 CL04-24 12.73 16.67 33.33 39.50 37.50 52.94 62.00 24.24 22.86 17 CL04-25A 8.20 20.00 54.55 19.30 42.11 46.67 65.85 45.95 100 18 CL04-25B 21.31 28.00 63.64 22.81 36.84 73.33 85.37 18.92 33.33 19 CL04-25C 34.43 44.00 100 40.35 57.89 66.67 100 83.78 100 20 CL04-25D 16.36 12.50 21.21 27.73 39.29 52.94 62.00 15.15 17.14 21 CL04-25E 9.09 16.67 45.45 10.92 35.71 52.94 54.00 21.21 11.43 22 CL04-17 35.71 50.00 60.87 47.83 100 86.67 81.48 58.82 47.37 23 CL04-32A 34.43 36.00 45.45 29.82 52.63 53.33 85.37 35.14 90.48 24 CL04-32B 40.98 52.00 81.82 64.91 47.37 80.00 100 78.38 100 25 CL04-32C 47.54 60.00 63.64 71.93 57.89 73.33 70.73 67.57 100 26 CL04-32D 54.10 84.00 100 64.91 84.21 73.33 85.37 89.19 100 27 CL04-32E 5.45 12.50 24.24 39.50 32.14 41.18 58.00 15.15 11.43 28 CL04-32F 12.73 12.50 60.61 57.98 42.86 52.94 62.00 21.21 20.00 29 CL04-00 21.54 22.60 29.63 36.97 32.44 22.64 12.03 21.28 32.02 30 CL04-00 44.44 65.00 50.00 61.21 75.00 66.67 85.71 53.91 76.36 31 Azoxystrobin 75.00 55.56 71.43 100 91.18 88.10 84.06 80.77 46.88 32 Enestroburin 50.00 55.22 21.54 59.09 48.57 44.00 73.97 57.50 32.97

(23) TABLE-US-00003 TABLE 3 Fungicidal Efficacy of the isothiazole oxime ether-containing strobilurin derivatives IV of the present invention against S. fuliginea field rate efficacy DD.sup.a Compd. (g/hm.sup.2) Base DI.sup.b After DI.sup.c (%) 5% 1% 9.60% 37.5 1.98 8.01 78.62 a A CL04-22D EC 250 g/L 37.5 1.66 9.59 70.19 b B Azoxystrobin SC 50% 37.5 1.64 10.04 68.02 b B Trifloxystrobin WG CK 1.07 20.63 .sup.aDD, distinct difference. .sup.bBase DI, disease index base. .sup.cAfter DI, disease index after compound application.

(24) TABLE-US-00004 TABLE 4 Fungicidal Efficacy of the isothiazole oxime ether-containing strobilurin derivatives IV of the present invention against P. cubensis Field rate Base efficacy DD.sup.a Compd. (g/hm.sup.2) DI.sup.b After DI.sup.c (%) 5% 9.60% CL04-22D EC 75 3.71 5.39 79.18 a 50% Trifloxystrobin WG 75 3.73 7.24 72.02 b 250 g/L Pyraclostrobin EC 75 3.57 5.78 77.52 a CK 3.58 24.96 .sup.aDD, distinct difference. .sup.bBase DI, disease index base. .sup.cAfter DI, disease index after compound application.

(25) TABLE-US-00005 TABLE 5 Anti-TMV activity of the isothiazole oxime ether-containing strobilurin derivatives IV of the present invention (100 g/mL, inhibition/%) Curative Inactivation Protection Induction Number Name effect effect effect effect 1 CL03-49 39.41 2.99 52.48 0.64 35.90 0.63 75.90 0.83 2 CL03-50 48.32 5.88 70.19 0.41 54.02 0.51 84.02 5.51 3 CL04-03 45.04 4.15 81.75 2.83 35.13 0.39 75.13 0.69 4 CL04-04-A 19.10 2.13 75.46 7.91 61.60 1.25 71.60 1.55 5 CL04-04-B 19.10 2.00 65.46 7.46 45.46 3.70 55.46 6.70 6 CL04-06 22.43 6.85 22.22 5.90 54.08 3.81 74.08 5.81 7 CL04-15A 1.52 0.62 54.76 1.26 40.53 0.84 70.53 0.84 8 CL04-15B 27.00 4.13 52.13 6.48 14.74 2.73 74.74 2.73 9 CL04-15C 1.52 0.62 59.94 2.76 25.08 4.33 85.08 5.33 10 CL04-22A 23.44 5.58 49.90 3.63 30.71 2.06 60.71 2.26 11 CL04-22B 1.52 0.62 36.70 4.98 53.10 0.75 53.10 0.75 12 CL04-22C 4.62 0.55 4.44 0.85 23.57 0.57 83.57 0.07 13 CL04-22D 32.78 3.36 4.44 0.85 49.05 2.77 79.05 7.77 14 CL04-22E 20.25 5.58 45.40 2.20 22.71 2.05 12.71 6.05 15 CL04-22F 1.52 0.62 0 23.76 3.42 63.76 3.52 16 CL04-24 14.96 3.08 27.30 6.56 36.78 5.50 46.78 7.70 17 CL04-25A 82.36 5.02 0 40.74 2.51 70.74 2.81 18 CL04-25B 20.51 1.84 0 19.56 3.36 18.56 3.76 19 CL04-25C 14.68 4.84 0 59.82 4.23 69.82 5.27 20 CL04-25D 35.93 1.63 0 21.15 1.69 21.15 3.69 21 CL04-25E 19.12 6.56 0 26.00 4.71 16.00 7.71 22 CL04-17 31.56 3.95 35.93 1.53 29.27 1.31 39.27 1.41 23 CL04-32A 1.52 0.62 37.75 6.62 45.32 2.00 45.32 2.00 24 CL04-32B 81.33 5.49 72.13 5.59 23.43 1.02 73.43 4.09 25 CL04-32C 31.56 3.91 41.40 0.92 19.00 0.72 16.00 7.71 26 CL04-32D 1.52 0.62 69.27 1.02 39.07 2.73 39.07 2.73 27 CL04-32E 1.52 0.62 13.65 0.55 40.79 0.77 70.79 3.77 28 CL04-32F 63.67 5.66 7.71 1.42 53.40 4.73 63.40 6.73 29 CL04-00 27.32 1.24 20.68 2.10 26.30 2.47 20.34 2.16 30 CL04-00 26.39 1.22 19.68 1.10 25.30 1.47 19.34 1.14 31 Ningnanmycin 74.10 2.04 32 TDL 65.00 2.00 33 BTH 78.10 0.54 78.00 1.34 34 SZG-7 79.00 2.27 35 Ribavirin 78.00 1.00 36 Isotianil 27.31 2.12 20.77 7.30 24.80 5.85 44.44 5.18

INDUSTRIAL APPLICABILITY

(26) The invention provides a class of the isothiazole oxime ether-containing strobilurin derivatives, a preparation method and application. The compounds of the invention provided can regulate the biological activity of plant pests and plant pathogens in agriculture, horticulture, sanitary and forestry, and also can be used in agriculture, horticulture, forestry, insecticide, acaricidal, fungicidal, anti-plant virus, induced plant defense responses, with good economic value and application prospects.