TERPENES AND THC COMPOSITIONS AND METHODS

Abstract

In embodiments described herein, there is provided a composition is provided including 1) a terpene comprising at least one of: a) a primary terpene; b) a secondary terpene; and c) a tertiary terpene; 2) THC including a) synthetic THC, or b) organic THC, or a combination thereof; and optionally, 3) a natural smokable.

Claims

1. A composition, comprising: a. a terpene comprising at least one of: i. a primary terpene; ii. a secondary terpene; and iii. a tertiary terpene; b. THC comprising: i. synthetic THC ii. organic THC; and optionally, c. a natural smokable.

2. The composition of claim 1, wherein the primary terpene comprises at least one of: -pinene, -bisabolol, -pinene, guaiene, guaiol, limonene, myrcene or ocimene.

3. The composition of claim 1, wherein the primary terpene is provided in an amount of 50% (w/w) or less of the formulation.

4. The composition of claim 1, wherein the secondary terpene is provided in an amount 50% (w/w) or less of the formulation.

5. The composition of claim 1, wherein the tertiary terpene is provided in an amount of 50% (w/w) or less of the formulation.

6. The composition of claim 1, wherein the primary terpene is provided in an amount of 50% (w/w), the secondary terpene is provided in an amount of 40% (w/w) and the tertiary terpene is provided in an amount of 10% (w/w) of the composition.

7. The composition of claim 1, wherein at least one of the primary terpene, secondary terpene and tertiary terpene comprises one or more of the group consisting of: monoterpenes, sesquiterpenes, flavonoids, phenols, diterpenes, cannabinoids, aldehydes, or esters.

8. The composition of claim 1, wherein the synthetic THC comprises at least one of: Dronabinol, Syndros, or Marinol.

9. The composition of claim 1, wherein organic THC comprises THC derived from a cannabis plant.

10. The composition of claim 1, wherein the natural smokable comprises: hemp flower, smoking herbs, tobacco, or cannabis.

11. (canceled)

12. The composition of claim 1, further comprising between 0.001 mg-40 mg nicotine.

13. A method of treating a nicotine addiction in a subject comprising: administering to the subject a therapeutically effective amount of the composition of claim 12.

14. The method of claim 13, comprising decreasing the percentage by weight of nicotine and increasing the percentage by weight of THC.

15. The method of claim 14, wherein the percentage by weight of nicotine is decreased in the same amount as the increase in percentage by weight of THC.

16. The method of claim 14, wherein the percentage of nicotine is decreased by at least 5% and the percentage of THC is increased by at least 5%.

17. The method of claim 13, wherein the therapeutically effective amount decreases by at least 10% per administration.

18. The method of claim 14, wherein the therapeutically effective amount decreases by at least 10% per week of administration.

19. The method of claim 12, wherein the composition is administered daily.

20. The method of claim 12, wherein the composition is administered weekly.

21. The composition of claim 1, further comprising a delivery system wherein the delivery system is selected from the group consisting of: smokables, tinctures, oils, vapes, chewing gum, patches, gels, pills, nasal spray, inhalers, snuff, suppositories, and gummies.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0144] A more particular description briefly stated above will be rendered by reference to specific embodiments thereof that are illustrated in the appended drawings. Understanding that these drawings depict only typical embodiments and are not therefore to be considered to be limiting of its scope, the embodiments will be described and explained with additional specificity and detail through the use of the accompanying drawings in which:

[0145] FIG. 1 includes a chart providing various embodiments of the formulation or composition. Numerous combinations are possible as shown in the chart. The chart of FIG. 1 provides various embodiments in which a smokable, a terpene, THC (synthetic and/or organic) and a delivery system are combined. However, in other embodiments, as otherwise described herein, one or more of these components may be omitted from the formulation. For example, a delivery system may include a smokable and terpenes only. In another embodiment, a smokable and THC may be combined with or without terpenes.

DETAILED DESCRIPTION

[0146] For the purposes of promoting an understanding of the principles and operation of the invention, reference will now be made to the embodiments illustrated in the drawings and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended, such alterations and further modifications in the illustrated device, and such further applications of the principles of the invention as illustrated therein being contemplated as would normally occur to those skilled in the art to which the invention pertains.

[0147] It is to be noted that the terms first, second, and the like as used herein do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. The terms a and an do not denote a limitation of quantity, but rather denote the presence of at least one of the referenced item. Furthermore, to the extent that the terms including, includes, having, has, with, or variants thereof are used in either the detailed description and/or the claims, such terms are intended to be inclusive in a manner similar to the term comprising. The modifier about used in connection with a quantity is inclusive of the stated value and has the meaning dictated by the context (e.g., includes the degree of error associated with measurement of the particular quantity). It is to be noted that all ranges disclosed within this specification are inclusive and are independently combinable.

[0148] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting. As used herein, the singular forms a, an, and the are intended to include the plural forms as well, unless the context clearly indicates otherwise these terms do not denote a limitation of quantity, but rather denote the presence of at least one of the referenced item. Furthermore, to the extent that the terms including, includes, having, has, with, or variants thereof are used in either the detailed description and/or the claims, such terms are intended to be inclusive in a manner similar to the term comprising. Moreover, unless specifically stated, any use of the terms first, second, etc., does not denote any order, quantity or importance, but rather the terms first, second, etc., are used to distinguish one element from another.

[0149] Notwithstanding that the numerical ranges and parameters setting forth the broad scope are approximations, the numerical values set forth in specific non-limiting examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements. Moreover, all ranges disclosed herein are to be understood to encompass any and all sub-ranges subsumed therein. As a non-limiting example, a range of less than 10 can include any and all sub-ranges between (and including) the minimum value of zero and the maximum value of 10, that is, any and all sub-ranges having a minimum value of equal to or greater than zero and a maximum value of equal to or less than 10, e.g., 1 to 7.

[0150] In one embodiment, a composition is provided including 1) a terpene comprising at least one of: a) a primary terpene; b) a secondary terpene; and c) a tertiary terpene; 2) THC including a) synthetic THC, or b) organic THC, or a combination thereof; and optionally, 3) a natural smokable.

[0151] The composition may include a primary terpene including at least one of -pinene, -bisabolol, -pinene, guaiene, guaiol, limonene, myrcene or ocimene. The primary terpene may be provided in an amount of 50% (w/w) or less of the formulation, in one example. The secondary terpene may be provided in an amount 50% (w/w) or less of the formulation, in one example. And the tertiary terpene may be provided in an amount of 50% (w/w) or less of the formulation, in one example.

[0152] In one non-limiting embodiment, the primary terpene may be provided in an amount of 50% (w/w), the secondary terpene is provided in an amount of 40% (w/w) and the tertiary terpene is provided in an amount of 10% (w/w) of the composition.

[0153] In one example the primary, secondary or tertiary terpene may be provided at 1%-100% by weight of the composition. In another example, the THC may be provided at 1%-100% by weight of the composition.

[0154] At least one of the primary terpene, secondary terpene and tertiary terpene may include one or more of the group consisting of: monoterpenes, sesquiterpenes, flavonoids, phenols, diterpenes, cannabinoids, aldehydes, or esters. The synthetic THC may include at least one of: Dronabinol, Syndros, or Marinol. The organic THC may include THC derived from a cannabis plant. Examples of natural smokables described herein may include hemp flower, smoking herbs, tobacco, or cannabis. The hemp flower may include CBD in some non-limiting examples. Smoking herbs described herein may include damiana, passion flower, or blue lotus, or a combination thereof.

[0155] The primary, secondary or tertiary terpene may be purified from a natural source, or may be synthetic, in non-limiting examples.

[0156] In one non-limiting embodiment, a method of treating a nicotine addiction in a subject is provided including administering to the subject a therapeutically effective amount of the compositions described herein. In one example, the composition includes nicotine. In a further embodiment, the method may include decreasing the percentage by weight of nicotine and increasing the percentage by weight of THC. In some non-limiting examples, the percentage by weight of nicotine may be decreased by the same amount as the increase in percentage by weight of THC over time. The method may further include further decreasing the percentage by weight of nicotine and increasing the percentage by weight of THC.

[0157] In the method embodiments described herein, the percentage of nicotine may be decreased by at least 5% and the percentage of THC may be increased by at least 5%.

[0158] In the method embodiments described herein, the therapeutically effective amount of the composition may be decreased by at least 10% per administration. In another embodiment, the method may be provided herein, wherein the therapeutically effective amount decreases by at least 10% per week of administration. In still another embodiment, the method may be provided, wherein the composition is administered to a subject daily. In another embodiment, the composition may be administered to the subject twice daily. In still another embodiment, the composition may be administered to the subject weekly or bi-weekly, in non-limiting examples.

[0159] In yet another embodiment, a formulation including a terpene, THC, and a delivery system may be provided. In a non-limiting example, the formulation may further include a natural smokable. The delivery system may be selected from the group consisting of: smokables, tinctures, oils, vapes, chewing gum, patches, gels, pills, nasal spray, inhalers, snuff, suppositories, and gummies. The formulation may be provided wherein the THC comprises synthetic THC which may include dronabinol, syndros, or marinol, in non-limiting examples. The formulation may include a terpene selected from the group consisting of: monoterpenes, sesquiterpenes, flavonoids and phenols, diterpene, cannabinoids, aldehydes, and esters. In one example, the formulation may include a natural smokable selected from the group consisting of: organic tobacco, smoking herbs, cannabis or hemp flower, or a combination thereof.

[0160] In still another embodiment, a formulation is provided including natural hemp; one or more natural terpenes; and synthetic THC. The formulation may include between 1-25 mg synthetic THC, in one non limiting example.

[0161] In at least one embodiment, a delivery system comprising a smokable, for example, may include a composition or formulation as described herein, including at least 5 mg of THC per smokable (or 100 mg THC per pack of smokables). The smokables may be in the form of a cigarette in a non-limiting example. The quantity of nicotine in the composition may include between 0.0001 mg nicotine and 40 mg nicotine in a non-limiting example. However, in a particular, non-limiting example, the quantity of nicotine in the composition include 11 mg, and the amount of the may include 5 mg during a first dosing cycle (wherein the dosing cycle may occur daily for one or more weeks, or weekly, for one or more months). In some examples, a first dosing cycle may include multiple doses per day. In a second dosing cycle, the amount of THC in the composition may be increased by 1 mg, for example, and the amount of nicotine in the composition may be decreased by 1 mg. In the third dosing cycle, the amount of THC in the composition may be further increased by 1 mg, for example, and the amount of nicotine in the composition may be further decreased by 1 mg. In some instances the quantity of each component may be increased or decreased by a greater or lesser amount depending on the side effects and impact to the user. Ultimately the nicotine may be decreased completely, or removed entirely from the composition and the THC could be increased to 16 mg, for example.

[0162] It may take approximately 16 packs of cigarettes to achieve a complete nicotine removal from the cigarettes or smokables. This process may be achieved with synthetic THC being combined with the tobacco or combining the tobacco with low dose THC cannabis bud. The same formula, method, and process applies to the terpenes being added to other smoking cultivars.

[0163] Reference to particular buffers, media, reagents, cells, culture conditions and the like, or to some subclass of same, is not intended to be limiting, but should be read to include all such related materials that one of ordinary skill in the art would recognize as being of interest or value in the particular context in which that discussion is presented. For example, it is often possible to substitute one buffer system or culture medium for another, such that a different but known way is used to achieve the same goals as those to which the use of a suggested method, material or composition is directed.

[0164] It is important to an understanding of the present invention to note that all technical and scientific terms used herein, unless defined herein, are intended to have the same meaning as commonly understood by one of ordinary skill in the art. The techniques employed herein are also those that are known to one of ordinary skill in the art, unless stated otherwise. For purposes of more clearly facilitating an understanding the invention as disclosed and claimed herein, the following definitions are provided.

[0165] While a number of embodiments of the present invention have been shown and described herein in the present context, such embodiments are provided by way of example only, and not of limitation. Numerous variations, changes and substitutions will occur to those of skill in the art without materially departing from the invention herein. For example, the present invention need not be limited to best mode disclosed herein, since other applications can equally benefit from the teachings of the present invention. Also, in the claims, means-plus-function and step-plus-function clauses are intended to cover the structures and acts, respectively, described herein as performing the recited function and not only structural equivalents or act equivalents, but also equivalent structures or equivalent acts, respectively. Accordingly, all such modifications are intended to be included within the scope of this invention as defined in the following claims, in accordance with relevant law as to their interpretation.