Dental wrap, dental kit comprising the same, method of using the same, and method for whitening teeth using the same

Abstract

A dental wrap is provided. The dental wrap includes an adhesive layer and a backing layer, which is characterized in that it does not contain an active ingredient. The present invention can improve the user's feeling of use by applying various flavors that were difficult to use in the tooth whitening agent.

Claims

1. A dental wrap comprising an adhesive layer and a backing layer, wherein the dental wrap does not contain an active ingredient, wherein the adhesive layer includes PVP and Pullulan, wherein the Pullulan is included in an amount of 0.01 to 3% by weight based on a total weight of dried adhesive layer, and the PVP is included in an amount of 40 to 60% by weight based on the total weight of the dried adhesive layer.

2. The dental wrap of claim 1, further including a flavor in an amount of 3 to 15% by weight based on a total weight of the adhesive layer.

3. The dental wrap of claim 1, wherein the adhesive layer does not contain EC and HPMC, but contains PVP.

4. The dental wrap of claim 3, wherein the adhesive layer further includes glycerin as a plasticizer.

5. The dental wrap of claim 4, wherein the PVP and the glycerin are included in the adhesive layer in a weight ratio of 1:0.5-0.8 (PVP:glycerin).

6. The dental wrap of claim 3, wherein the adhesive layer includes a surfactant in an amount of 4 to 7% by weight based on a total weight of the adhesive layer.

7. The dental wrap of claim 3, wherein the adhesive layer further includes an additional polymer, wherein the additional polymer is selected from the group consisting of carboxymethyl cellulose, cellulose acetate, shellac and a mixture thereof.

8. The dental wrap of claim 7, wherein the PVP and the additional polymer are included in the adhesive layer in a weight ratio of 1:0.1 to 0.2.

9. The dental wrap of claim 1, having an embossed pattern including a pocket.

10. The dental wrap of claim 1, having a thickness of 30 m to 100 m.

11. A kit for delivering an oral active ingredient to the teeth, comprising: a) a dental wrap including: an adhesive layer, wherein the adhesive layer includes PVP and Pullulan, wherein the Pullulan is included in an amount of 0.01 to 3% by weight based on a total weight of dried adhesive layer, and the PVP is included in an amount of 40 to 60% by weight based on the total weight of the dried adhesive layer, and does not contain the oral active ingredient, and a backing layer laminated on the adhesive layer; and b) a composition containing the oral active ingredient.

12. The kit of claim 11, further comprising c) a manual for use.

13. The kit of claim 11, wherein b) the composition containing the oral active ingredient contains carbomer in an amount of 0.5 to 10% by weight based on a total weight of the composition.

14. A method for tooth whitening, comprising: S1) treating a composition containing an ingredient for tooth whitening to the teeth; and S2) wrapping the teeth treated with the composition with a dental wrap comprising an adhesive layer, and a backing layer laminated on the adhesive layer, wherein the adhesive layer contains PVP and Pullulan, wherein the Pullulan is included in an amount of 0.01 to 3% by weight based on a total weight of dried adhesive layer, and the PVP is included in an amount of 40 to 60% by weight based on the total weight of the dried adhesive layer, and does not contain the oral active ingredient.

Description

DESCRIPTION OF DRAWINGS

(1) The accompanying drawings illustrate a preferred embodiment of the present invention and together with the foregoing invention, serve to provide further understanding of the technical features of the present invention, and thus, the present invention is not construed as being limited to the drawing.

(2) FIG. 1 is a diagram schematically illustrating a kit including gel for whitening the teeth and wrap for attaching the teeth according to an embodiment of the present invention.

(3) FIG. 2 is a diagram schematically illustrating a method for measuring Ball tackiness.

(4) FIG. 3 is a diagram illustrating a process of measuring the force when peeling off wrap from PET.

(5) FIG. 4 illustrates a process of measuring the curling degree of wrap.

(6) FIG. 5 illustrates the results of measuring the length after peeling of Wrap 1 and Wrap 4.

MODE FOR DISCLOSURE

(7) Hereinafter, in order to describe the present invention in more detail, it will be described with reference to the following embodiments. However, the embodiments according to the present invention may be modified in various forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. The embodiments of the present invention are provided by way of example to aid in a specific understanding of the present invention. Unless otherwise specified, % described herein can be understood to mean % by weight.

(8) [Dental Gel-Wrap Drug Delivery System]

(9) As follows, a kit including gel and wrap was prepared. In FIG. 1, the kit 100 includes wrap 107 and gel 103. The wrap 107 includes an adhesive layer 101 and backing layer 102. This kit includes an active ingredient for whitening teeth in the gel, and the wrap includes flavor, but does not include an active ingredient for whitening teeth. Table 1 below shows the composition of the gel, and Table 2 below shows the composition of the adhesive layer of the wrap.

(10) TABLE-US-00001 TABLE 1 Ingredient Gel Hydrogen peroxide 6.0 Glycerin 20.0 Carbomer 1.8 Sodium hydroxide 0.08 Sodium saccharin 0.1 Purified water To 100

(11) TABLE-US-00002 TABLE 2 Ingredient Wrap1 Wrap2 Wrap3 Wrap4 Glycerin 26.6 34.0 30.2 33.1 HCO-40 5.0 4.4 SPAN80 3.3 PVP 59.2 42.5 47.7 44.2 Pullulan 0.05 HPMC 5.0 EC 8.5 Sodium phosphate 1.5 1.5 1.5 tribasic Sodium hydroxide 0.3 Saccharin 0.6 0.6 0.5 0.5 Flavor 5.6 5.7 5.0 5 Ethanol 2.8 Purified water To 100 To 100 To 100 To 100

(12) The manufacturing method is as follows.

(13) GelRaw materials excluding a neutralizing agent are added to a mixing tank, stirred homogeneously, and after confirming that there is no dissolution or lumped mass, carbomer is neutralized to increase the viscosity. The viscosity is adjusted in the range of 20,000 to 480,000 after rotation using Brookfield Viscometer (RV) Spindle No. 7 at 20 rpm for 15 seconds.

(14) WrapAfter putting raw materials into a mixing tank and stirring it homogeneously, the mixture was applied to a certain thickness using a comma coater, dried by blowing dry hot air (40-60 C.), and then the backing layer (Low density polyethylene (LDPE)) was laminated thereto. (Solvent casting)

(15) [Method of use]

(16) Gels and wraps having the compositions of Table 1 and Table 2 above were prepared, respectively, and used for tooth whitening. The gel was used in a fixed amount, and stored in a syringe pump with a shut-off valve to prevent leakage. A fixed amount of gel discharged from the syringe pump was applied to the tooth surface. When used about 0.2-0.6 g per use, the gel flows into the teeth as well as the tooth surface, so it was effective for whitening between teeth.

(17) The wrap was detached from the release liner and then attached to the tooth surface.

(18) [Tackiness Measurement]

(19) It was measured using a TA/TX analyzer. After attaching the backing layer of the wrap product to the bottom of the device using double-sided tape, the release liner was remove from the adhesive layer and the Ball tackiness was measured. (Dry/Wet) The experimental method is schematically shown in FIG. 2. In FIG. 2, the wrap 107 was attached to double-sided tape 104. Once the wrap was attached, a ball 105 was placed on the adhesive layer of the wrap 101. After a specific amount of time, the ball 105 was removed from the adhesive layer 101.

(20) Wetting method: Purified water is sprayed once using a spray.

(21) Pressing time (5 sec), Pressing force (5 gf), Peeling speed (10 mm/sec) Adhesion according to the prescription is shown in Table 3.

(22) TABLE-US-00003 TABLE 3 F average(gf) F Max(gf) F Min(gf) (S.D.) Wrap 1 150.1 66.7 110.7 (35.039) Wrap 2 143.9 80.0 115.1 (26.914) Wrap 3 43.1 21.7 29.5 (10.041) Wrap 4 99.3 78.5 91.6 (11.378) *F Max(gf): Maximum force until falling, F Min(gf): Minimum force until falling

(23) Adhesion according to wetting is shown in Table 4.

(24) TABLE-US-00004 TABLE 4 F average(gf) Number Wetting F Max(gf) F Min(gf) (S.D.) Wrap 4 Dry 99.3 78.5 91.6 (11.378) Wet 178.3 143.1 161.0 (17.638)

(25) The force when peeling off the Wrap from PET was measured, and the experimental method is shown in FIG. 3.

(26) The TA/TX analyzer was used. As illustrated in FIG. 3, after attaching the release liner of the Wrap product 106 to the bottom of the device using double-sided tape 104, the backing layer and a cylindrical tip (diameter 5 mm) 108 were attached by pressing the backing layer with the tip with double-sided tape 109 attached. Then, the force when the Wrap fell from the release liner was measured, and the tip was attached to one end of the Wrap size (10 mm25 mm). Pressing time (5 sec), Pressing force (1000 gf), Peeling speed (10 mm/sec)

(27) TABLE-US-00005 TABLE 5 F average(gf) Number F Max(gf) F Min(gf) (S.D.) Wrap 1 733.8 665.3 710.7 (39.338) Wrap 2 351.0 245.9 308.0 (55.055) Wrap 3 325.2 225.4 274.6 (53.096) Wrap 4 362.5 200.8 306.7 (91.744)

(28) [Comparison of Wrap Curling Degree]

(29) The experimental method is as follows, and is illustrated in FIG. 4.

(30) 1. After uniformly cutting the Wrap into 70 mm in length and 20 mm in width, the release liner is attached and fixed to the bottom of the device using double-sided tape.

(31) 2. Using tape, Zwick universal tester and the backing layer of the Wrap are attached.

(32) 3. The Wrap was peeled off from the release liner by pulling at a certain speed. (13 mm/sec)

(33) 4. The length of the Wrap was measured without unfolding the Wrap again.

(34) The curling results using the wrap of Table 2 are shown in Table 6 below.

(35) TABLE-US-00006 TABLE 6 Number Length after peeling (mm) Wrap 1 44 Wrap 2 63 Wrap 3 62 Wrap 4 68

(36) Wrap 1 was easily curled up when peeling, so that length was shortened. A photograph of the experimental results of Wrap 1 and Wrap 4 is shown in FIG. 5.