COSMETIC COMPOSITION INCLUDING MICROSPHERES CONTAINING HIGH CONCENTRATION OF OXYGEN AND METHOD OF PREPARING THE SAME

Abstract

The present invention provides a cosmetic composition including oxygen-containing microspheres for preventing skin aging, in which the microsphere contains 25 to 35 ppm of oxygen. The cosmetic composition including the microsphere according to the present invention is capable of supplying a high concentration of oxygen to the skin by allowing a high concentration of oxygen to slowly release through the microspheres.

Claims

1. A cosmetic composition including oxygen-containing microspheres for preventing skin aging, wherein the microsphere contains 25 to 35 ppm of oxygen.

2. The cosmetic composition of claim 1, wherein the microsphere was produced by: homogenizing about 5.0 to 6.0 parts by weight of poloxamer 188 and 1.5 to 2.5 parts by weight of glycerin with respect to 100 parts by weight of purified water under a condition of about 80 to 90 C.; cooling the homogenized aqueous solution to 23 to 27 C.; adding 25 to 55 parts by weight of oxygen water in which 95 to 105 ppm of oxygen is dissolved to the cooled aqueous solution and stirring the solution; and mixing the stirred solution with 35 to 69 parts by weight of a fluorine compound selected from the group consisting of perfluorodecalin, methyl perfluoroisobutyl ether, and perfluoropolymethylisopropyl ether under a condition of 20 to 30 C., and making the mixture pass through a high pressure homogenizer.

3. The cosmetic composition of claim 1, wherein the cosmetic composition is prepared by adding one or more materials selected from the group consisting of acrylate/C10-30 alkyl acrylate cross polymer, polysorbate, triethanolamine, a flavoring agent, and a preservative to the microsphere in an appropriate amount, and dispersing and stabilizing the material, following by aging for 2 to 7 days.

4. The cosmetic composition of claim 2, wherein the perfluorodecalin is 25 to 55 parts by weight, and the perfluoropolymethylisopropyl ether is 10 to 14 parts by weight.

Description

DETAILED DESCRIPTION

[0018] Objects, effects, and technical configurations for achieving them will be clear when exemplary embodiments described in detail with reference to the accompanying drawings are referred to. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein is omitted to avoid making the subject matter of the present invention unclear. In addition, the terminology used in the description is defined in consideration of the function of corresponding components used in the present invention and may be varied according to users.

[0019] However, the present invention is not limited to exemplary embodiments disclosed herein but will be implemented in various forms. The exemplary embodiments are provided so that the present invention is completely disclosed, and a person of ordinary skilled in the art can fully understand the scope of the present invention, and the present invention will be defined only by the scope of the appended claims. Accordingly, the definitions thereof should be made based on the entire contents of the present specification.

[0020] Hereinafter, a cosmetic composition including microspheres according to an exemplary embodiment of the present invention will be described in detail with reference to the accompanying drawings.

[0021] A cosmetic composition including microspheres according to an exemplary embodiment of the present invention includes about 25 to 35 ppm oxygen. The microsphere has excellent skin penetration and may supply oxygen so that oxygen can be stably preserved without losing long-term activity.

[0022] The microsphere may be produced by encapsulating oxygen water containing about 100 ppm or more of oxygen water and adding the encapsulated microsphere to a cosmetic material.

[0023] More particularly, the microsphere may be produced by homogenizing about 5.0 to 6.0 parts by weight of poloxamer 188 and about 1.5 to 2.5 parts by weight of glycerin with respect to 100 parts by weight of purified water under a condition of about 80 to 90 C., cooling the homogenized aqueous solution to about 23 to 27 C., and adding about 25 to 55 parts by weight of oxygen water in which about 95 to 105 ppm of oxygen is dissolved to the cooled aqueous solution and stirring the solution. Next, the stirred solution is mixed with about 35 to 69 parts by weight of a fluorine compound selected from the group consisting of perfluorodecalin (PFC), methyl perfluoroisobutyl ether, and perfluoropolymethylisopropyl ether under a condition of about 20 to 30 C., and the mixture passes through a high pressure homogenizer. Methyl perfluoroisobutyl ether is the component usable while being be replaced with perfluorodecarine, and may be replaced with perfluorodecarine in the same amount as that of the methyl perfluoroisobutyl ether for use.

[0024] Herein, perfluorodecaline (C.sub.10F.sub.18) is a compound of fluorine and carbon and is a material that dissolves the large amount of oxygen. Perfluorodecaline has been known as a material capable of dissolving about 21% (up to 45%) of oxygen that is similar to the concentration of oxygen in the atmosphere.

[0025] Perfluorodecaline is a component for containing a high concentration of oxygen for producing the microsphere, and may supply a high concentration of oxygen to the microsphere by making perfluorodecaline and perfluoropolymethylisopropyl ether pass through the high pressure homogenizer together or separately.

[0026] An emulsification stabilization supplement may be contained for stabilizing the oxygen containing microsphere. Examples of the emulsification stabilization supplement may include a polymer, such as glycerin, xylitol, and a natural polymer compound. In this case, the emulsification stabilization supplement may be used in the amount of about 0.1 to 3.0 parts by weight with respect to the total weight of the composition.

[0027] A concentration of oxygen contained in the microsphere may be about 30 ppm, and when the concentration of oxygen is equal to or less than 30 ppm, the microsphere is processed until the concentration of oxygen becomes about 30 ppm by additionally adding about 5 to 20 parts by weight of the oxygen water (100 ppm) and making the solution pass through the high pressure homogenizer.

[0028] By the cosmetic composition including the microsphere according to the exemplary embodiment of the present invention, it is possible to mix oxygen to a cosmetic material in a higher concentration state than before, and improve permeability when the cosmetic composition is applied to the skin, thereby providing the cosmetic material effective to the skin.

[0029] The present invention will be described in more detail through the following Examples, but the present invention is not limited by the following Examples.

[0030] <Method of Producing Microsphere>

Example 1

[0031] A. Prepare Stirred Solution

[0032] With respect to 100 parts by weight of purified water under a condition of about 80 to 90 C., about 5.5 parts by weight of poloxamer 188 and about 2 parts by weight of glycerin were homogenized, followed by cooling the homogenized aqueous solution to about 23 to 27 C.

[0033] Oxygen water in which about 100 ppm of oxygen was dissolved was added to the cooled aqueous solution by about 30 parts by weight and stirred to prepare a stirred solution.

[0034] B. Produce Microsphere

[0035] Next, the stirred solution, about 50 parts by weight of perfluorodecalin, and about 12 parts by weight of perfluoropolymethylisopropyl ether were mixed under a condition of about 20 to 30 C. at 900 to 1,100 rpm, followed by making the mixture pass through a high pressure homogenizer.

Example 2

[0036] A. Prepare Stirred Solution

[0037] With respect to 100 parts by weight of purified water under a condition of about 80 to 90 C., about 5.5 parts by weight of poloxamer 188 and about 2 parts by weight of glycerin were homogenized, followed by cooling the homogenized aqueous solution to about 23 to 27 C.

[0038] Oxygen water in which about 100 ppm of oxygen was dissolved was added to the cooled aqueous solution by about 30 parts by weight and stirred to prepare a stirred solution.

[0039] B. Produce Microsphere

[0040] Next, the stirred solution, about 30 parts by weight of perfluorodecalin, and about 12 parts by weight of perfluoropolymethylisopropyl ether were mixed under a condition of about 20 to 30 C. at 900 to 1,100 rpm, followed by making the mixture pass through a high pressure homogenizer.

Example 3

[0041] A. Prepare Stirred Solution

[0042] With respect to 100 parts by weight of purified water under a condition of about 80 to 90 C., about 5.5 parts by weight of poloxamer 188 and about 2 parts by weight of glycerin were homogenized, followed by cooling the homogenized aqueous solution to about 23 to 27 C.

[0043] Oxygen water in which about 100 ppm of oxygen was dissolved was added to the cooled aqueous solution by about 30 parts by weight and stirred to prepare a stirred solution.

[0044] B. Produce Microsphere

[0045] Next, the stirred solution, about 15 parts by weight of perfluorodecalin, and about 6 parts by weight of perfluoropolymethylisopropyl ether were mixed under a condition of about 20 to 30 C. at 900 to 1,100 rpm, followed by making the mixture pass through a high pressure homogenizer.

Example 4

[0046] A. Prepare Stirred Solution

[0047] With respect to 100 parts by weight of purified water under a condition of about 80 to 90 C., about 5.5 parts by weight of poloxamer 188 and about 2 parts by weight of glycerin were homogenized, followed by cooling the homogenized aqueous solution to about 23 to 27 C.

[0048] Oxygen water in which about 100 ppm of oxygen was dissolved was added to the cooled aqueous solution by about 30 parts by weight and stirred to prepare a stirred solution.

[0049] B. Produce Microsphere

[0050] Next, the stirred solution and about 32 parts by weight of perfluoropolymethylisopropyl ether were mixed under a condition of about 20 to 30 C. at 900 to 1,100 rpm, followed by making the mixture pass through a high pressure homogenizer.

Comparative Example 1

[0051] A. Prepare Stirred Solution

[0052] With respect to 100 parts by weight of purified water under a condition of about 80 to 90 C., about 0.2 parts by weight of acrylate/C10-30 alkyl acrylate cross polymer, about 0.2 parts by weight of polysorbate, and about 0.2 parts by weight of triethanolamine were homogenized, followed by cooling the homogenized aqueous solution to about 23 to 27 C.

[0053] Oxygen water in which about 100 ppm of oxygen was dissolved was added to the cooled aqueous solution by about 30 parts by weight and stirred to prepare a stirred solution.

[0054] B. Produce Microsphere

[0055] Next, the stirred solution and about 50 parts by weight of perfluorodecalin were mixed under a condition of about 20 to 30 C. at 900 to 1,100 rpm, followed by making the mixture pass through a high pressure homogenizer.

Comparative Example 2

[0056] A. Prepare Stirred Solution

[0057] With respect to 100 parts by weight of purified water under a condition of about 80 to 90 C., about 0.2 parts by weight of acrylate/C10-30 alkyl acrylate cross polymer, about 0.2 parts by weight of polysorbate, and about 0.2 parts by weight of triethanolamine were homogenized, followed by cooling the homogenized aqueous solution to about 23 to 27 C.

[0058] Oxygen water in which about 100 ppm of oxygen was dissolved was added to the cooled aqueous solution by about 30 parts by weight and stirred to prepare a stirred solution.

[0059] B. Produce Microsphere

[0060] Next, the stirred solution and about 30 parts by weight of perfluorodecalin were mixed under a condition of about 20 to 30 C. at 900 to 1,100 rpm, followed by making the mixture pass through a high pressure homogenizer.

Comparative Example 3

[0061] A. Prepare Stirred Solution

[0062] With respect to 100 parts by weight of purified water under a condition of about 80 to 90 C., about 0.2 parts by weight of acrylate/C10-30 alkyl acrylate cross polymer, about 0.2 parts by weight of polysorbate, and about 0.2 parts by weight of triethanolamine were homogenized, followed by cooling the homogenized aqueous solution to about 23 to 27 C.

[0063] Oxygen water in which about 100 ppm of oxygen was dissolved was added to the cooled aqueous solution by about 30 parts by weight and stirred to prepare a stirred solution.

[0064] B. Produce Microsphere

[0065] Next, the stirred solution and about 15 parts by weight of perfluorodecalin were mixed under a condition of about 20 to 30 C. at 900 to 1,100 rpm, followed by making the mixture pass through a high pressure homogenizer.

Comparative Example 4

[0066] A. Prepare Stirred Solution

[0067] With respect to 100 parts by weight of purified water under a condition of about 80 to 90 C., about 0.2 parts by weight of acrylate/C10-30 alkyl acrylate cross polymer, about 0.2 parts by weight of polysorbate, and about 0.2 parts by weight of triethanolamine were homogenized, followed by cooling the homogenized aqueous solution to about 23 to 27 C.

[0068] Oxygen water in which about 100 ppm of oxygen was dissolved was added to the cooled aqueous solution by about 30 parts by weight and stirred to prepare a stirred solution.

[0069] B. Produce Microsphere

[0070] Next, the stirred solution and about 32 parts by weight of perfluoropolymethylisopropyl ether were mixed under a condition of about 20 to 30 C. at 900 to 1,100 rpm, followed by making the mixture pass through a high pressure homogenizer.

[0071] Table 1 below represents a composition ratio according to the production of the microsphere.

TABLE-US-00001 TABLE 1 Example Comparative Example NO. Component 1 2 3 4 1 2 3 4 1 Purified water 100 100 100 100 100 100 100 100 2 Oxgyen water (100 30 30 30 30 30 30 30 30 ppm) 3 Poloxamer 188 5.4 5.4 5.4 5.4 4 Glycerin 2 2 2 2 5 Perfluorodecalin 50 30 15 50 30 15 6 Perfluoropolymethylisopropyl 12 12 6 32 32 ether 7 Acrylate/C10-30 alkyl 0.2 0.2 0.2 0.2 acrylate cross polymer 8 Polysorbate 0.2 0.2 0.2 0.2 9 Triethanolamine 0.2 0.2 0.2 0.2

[0072] Table 2 below represents a measurement result of oxygen concentrations of the microspheres according to Examples 1 to 4 and Comparative Examples 1 to 4.

TABLE-US-00002 TABLE 2 Experimental Example Example Example Example Comparative Comparative Comparative Comparative Example 1 2 3 4 Example 1 Example 2 Example 3 Example 4 Oxygen 35 37 33 31 13 14 10 10 concentration (ppm)

[0073] <Prepare Cosmetic Composition>

Examples 5-1 to 5-4

[0074] With respect to 100 parts by weight of purified water under a condition of about 20 to 30 C., about 3.0 parts by weight of polyacrylamide/C12 isoparaffin/laures-7 was mixed, and about 20.0 parts by weight of almond oil was added and mixed slowly.

[0075] The mixed solution and about 10 parts by weight of the microspheres produced according to Examples 1 to 4 were mixed and aged for about 2 to 7 days.

Comparative Example 5

[0076] With respect to 100 parts by weight of purified water under a condition of about 20 to 30 C., about 3.0 parts by weight of polyacrylamide/C12 isoparaffin/laures-7 was mixed, and about 20.0 parts by weight of almond oil was added and mixed slowly.

[0077] The mixed solution and about 5.0 parts by weight of perfluorodecalin were mixed and aged for about 2 to 7 days.

[0078] Table 3 below represents the composition ratios of Example 5 and Comparative Example 5.

TABLE-US-00003 TABLE 3 Examples Comparative NO. Component 5-1 to 5-4 Example 5 1 Purified water 100 100 2 Perfluorodecalin 5.0 3 Microspheres of 10.0 Examples 1 to 4 4 Almond oil 20.0 20.0 5 Polyacrylamide/C12 3.0 3.0 isoparaffin/laures-7

[0079] <Centrifugal Stability Test>

[0080] In order to examine the centrifugal stability of the cosmetic compositions prepared according to Examples 5-1 to 5-4 and Comparative Example 5, each product was prepared by about 500 g, and the appropriate and same amount of cosmetic composition was centrifuged at about 4,000 RPM for about 10 minutes, about 8,000 RPM for about 10 minutes, and about 12,000 RPM for about 10 minutes, and the results thereof are represented in Table 3.

[0081] Table 4 represents a result of the centrifugal stability test.

TABLE-US-00004 TABLE 4 Experimental 4,000 RPM 8,000 RPM 12,000 RPM Example (10 minutes) (10 minutes) (10 minutes) Example 5-1 Stable Stable Stable Example 5-2 Stable Stable Stable Example 5-3 Stable Stable Stable Example 5-4 Stable Stable Stable Comparative Small-amount Separate Example 5 separate

[0082] As can be seen in the result of the centrifugal stability test of the table, it was confirmed that Examples 5-1 to 5-4 for the cosmetic composition including the microsphere containing oxygen had no problem in centrifugal stability compared to Comparative Example 5 containing oxygen.

[0083] <Temporal Stability Test>

[0084] In order to examine temporal stability of the cosmetic compositions prepared according to Examples 5-1 to 5-4 and Comparative Example 5, about 500 g of each product was contained in a transparent glass container and stored at a room temperature (about 25 C.), a high temperature (about 45 C.), and sunlight and freezing-thawing room (45 C. to 10 C., 24 hour cycle), and the obtained results are represented in Table 5.

TABLE-US-00005 TABLE 5 Comparative Storage condition Example 5-1 Example 5-2 Example 5-3 Example 5-4 Example 5 About 1 month Stable Stable Stable Stable Stable 25 C. 3 months Stable Stable Stable Stable Separate 6 months Stable Stable Stable Stable 1 year Stable Stable Stable Stable About 1 month Stable Stable Stable Stable Stable 45 C. 3 months Stable Stable Stable Stable Separate 6 months Stable Stable Stable Stable 1 year Stable Stable Stable Stable Sunlight 1 month Stable Stable Stable Stable Stable 3 months Stable Stable Stable Stable Separate 6 months Stable Stable Stable Stable 1 year Stable Stable Stable Stable About 1 week Stable Stable Stable Stable Stable 45 C. <--> 2 weeks Stable Stable Stable Stable Stable About 3 weeks Stable Stable Stable Stable Separate 10 C. 4 weeks Stable Stable Stable Stable

[0085] <Nutritional Cream Formulation Including Microsphere>

Formulation Examples 1-1 to 1-4

[0086] About 2.0 parts by weight of wax, about 1.5 parts by weight of polysorbate 60, about 0.8 parts by weight of sorbitan sesquioleate, about 5.0 parts by weight of liquid paraffin, about 5.0 parts by weight of squalene, about 4.0 parts by weight of caprylic/capric triglyceride, and about 0.2 parts by weight of triethanolamine were inserted while mixing and stirring about 0.2 parts by weight of carboxy vinyl polymer, about 5.0 parts by weight of glycerin, about 3.0 parts by weight of butylene glycol, about 3.0 parts by weight of propylene glycol, followed by emulsification by heating at about 80 to 85 C.

[0087] After the emulsification is completed, the mixture was stirred and cooled to about 40 C., and then the microspheres according to Examples 1 to 4 were inserted, and the mixture was cooled to about 25 C. while stirring the mixture with a paddle mixer at about 25 rpm and the aged.

Comparative Formulation Example 1

[0088] About 2.0 parts by weight of wax, about 1.5 parts by weight of polysorbate 60, about 0.8 parts by weight of sorbitan sesquioleate, about 5.0 parts by weight of liquid paraffin, about 5.0 parts by weight of squalene, about 4.0 parts by weight of caprylic/capric triglyceride, and about 0.2 parts by weight of triethanolamine were inserted while mixing and stirring about 0.2 parts by weight of carboxy vinyl polymer, about 5.0 parts by weight of glycerin, about 3.0 parts by weight of butylene glycol, about 3.0 parts by weight of propylene glycol, followed by emulsification by heating at about 80 to 85 C.

[0089] After the emulsification is completed, the mixture was stirred and cooled to about 40 C., followed by aging.

[0090] Table 6 below represents the composition ratios of Formulation Examples 1-1 to 1-4 and Comparative Formulation Example 1.

TABLE-US-00006 TABLE 6 Comparative Formulation Formulation NO. Raw material Example 1 Example 1 1 Microsphere (Examples 1-4) 10.0 2 Wax 2.0 2.0 3 Polysorbate 60 1.5 1.5 4 Sorbitan sesquioleate 0.8 0.8 5 Liquid paraffin 5.0 5.0 6 Squalene 5.0 5.0 7 Caprylic/capric triglyceride 4.0 4.0 8 Carboxy vinyl polymer 0.2 0.2 9 Glycerin 5.0 5.0 10 Butylene glycol 3.0 3.0 11 Propylene glycol 3.0 3.0 12 Triethanolamine 0.2 0.2

[0091] The following preference investigation was conducted to identify the effect of improving the skin condition when the nutritional creams of Formulation Examples 1-1 to 1-4 and Comparative Formulation Example 1-1 were applied to the skin. The people who participated in the test were female groups of about 20 to 55 years old, who consisted of 50 of normal, oily, dry, and complex skins, each composed of 25%, to examine the skin condition improvement and skin oil and moisture conditions. To the same person, the person applied the nutritional cream of Formulation Example 1 to the skin at the left side of the face and applied the nutritional cream of Comparative Formulation Example 1 to the skin at the right side of the face every morning for 20 days once a day after washing the face, and in order to identify the improvement of the skin condition, a survey was conducted on the degree of skin condition improvement. The test result is represented in Table 7 below.

TABLE-US-00007 TABLE 7 Skin condition improvement Classification Number of people % Formulation Very good 31 62.0 Example 1 Good 14 28.0 Normal 5 10.0 So-so 0 0.0 Comparative Very good 5 10.0 Formulation Good 18 36.0 Example 1 Normal 16 32.0 So-so 11 22.0

[0092] As represented in the survey result, it can be seen that Formulation Example 1 including the microsphere containing oxygen has the excellent skin improvement effect, compared to the case of Comparative Formulation Example 1.

[0093] The exemplary embodiments of the present invention are disclosed in the present specification and the drawings and the specific terms are used. However, the specific terms are used as general meanings simply for the purpose of clearly describing the present invention and helping the understanding of the invention, and do not intend to limit the scope of the present invention. It is obvious to those skilled in the art that other modification examples based on the technical spirit of the present invention, in addition to the exemplary embodiment disclosed herein may be carried out.