COMPOUNDS AND COMPOSITIONS HAVING KNOCK-DOWN OR BLOOD FEED INHIBITION ACTIVITY AGAINST INSECT PESTS

Abstract

With the present invention it has now been found that certain 4-trifluoromethylnicotinamide mixtures and active compound compositions comprising such mixtures are suitable for controlling nuisance, disease carrying or haematophagous (blood feeding) insects pests incl. dipteran, triatominae, culicoide and cimicidae insect pests by knockdown or by or blood feed inhibition. In one embodiment, dipteran pests are selected from flies, biting midges and mosquitoes, including insecticide-resistant flies, midges and mosquitoes, as well as fly, midge and mosquito vectors of pathogenic disease. Target cimicidae insect pests are selected from bed bugs. Target triatominae pests are selected from kissing bugs Other aspects of the present invention will also be apparent in the detailed description which follows.

Claims

1. A method for controlling a nuisance, disease carrying or haematophagous dipteran, triatominae, culicoide, or cimicidae insect pest comprising: applying a composition containing a knockdown or blood feed inhibiting effective amount of a first insecticide (a) 4-trifluoromethylnicotinamide and a second insecticide (b) to such insect pest or to a locus where such control is desired, wherein the the second insecticide (b) is selected from the group consisting of abamectin, alpha-cypermethrin, amitraz, avermectin, azadirachtin, bendiocarb, bifenthrin, broflanilide, buprofezin, clothianidin, cypermethrin, cyromazine, d-d, trans cyphenothrin, diafenthiuron, dicofol, dinotefuran, diflumetorim, emamectin benzoate, etofenprox, etoxazole, fenitrothion, fenazaquin, fenoxycarb, fenpyroximate, fipronil, fluacrypyrim, flubendiamide, flupyradifurone, fluazinam, imidacloprid, malathion, metaflumizone, picoxystrobin, propoxur, pyriproxyfen, spinosad, sulfoxaflor, tebufenpyrad, thiamethoxam, trifloxystrobin, triflumizopyrim and a compound represented by the formulae 42-63: ##STR00025## ##STR00026## ##STR00027## ##STR00028##

2. The method of claim 1, wherein said insect pest is a mosquito.

3. A method for controlling mosquitoes, the method comprising applying to the mosquito or to a locus of potential or known interaction between the human or mammal and the mosquito, an active compound composition comprising a knockdown or blood feed inhibiting effective amount of a composition comprising a mixture as described in claim 1.

4. The method of claim 3, wherein the active compound composition is applied to a non-living material or substrate at a locus of potential or known interaction between the mosquito and said human or mammal.

5. The method of claim 3, wherein the mosquito is selected from Aedes aegypti, Aedes albopictus, Aedes japonicas, Aedes vexans, Culex molestus, Culex pallens, Culex pipiens, Culex quinquefasciatus, Culex restuans, Culex tarsalis, Anopheles albimanus, Anopheles arabiensis, Anopheles darlingi, Anopheles dirus, Anopheles funestus, Anopheles gambiae s.I., Anopheles melas, Anopheles minimus, Anopheles sinensis, Anopheles stephensi, Mansonia titillans.

6. The method of claims 5, wherein said mosquito is a vector of malaria.

7. An integrated mosquito vector control solution for causing knockdown or blood feed inhibition of a dipteran, culicoide, or cimicidae insect pest comprising a 4-trifluoromethylnicotinamide mixture as defined in claim 1.

8. The vector control solution according to claim 7, wherein the solution is a composition for spraying surfaces of a dwelling, which composition comprises one or more of said 4-trifluoromethylnicotinamide mixtures.

9. A polymeric material for causing knockdown or blood feed inhibition of a dipteran, culicoide, or cimicidae insect pest incorporated with 4-trifluoromethylnicotinamide mixture as defined in claim 1, which material is useful for making substrate or non-living material, such as threads, fibres, yarns, pellets, nets and weaves.

10. A method of controlling mosquitoes by knockdown or blood feed inhibition, preferably mosquito vectors of pathogenic disease, with with a 4-trifluoromethylnicotinamide as defined in claim 1.

11. A kit for treating a fibre, yarn, net and weave by coating wash resistant insect control properties thereto comprising: a first sachet comprising a pre-measured amount of a 4-trifluoromethylnicotinamide mixture as defined in claim 1, and a second sachet comprising a pre-measured amount of at least one polymeric binder.

12. A method for treating a fibre, yarn, net and weave by coating wash resistant insect control properties thereto comprising (i) preparing a treatment composition, which comprises a 4-trifluoromethylnicotinamide mixture as defined in claim 1, (ii) treating said fibre, yarn, net and weave and (iii) drying the resulting treated a fibre, yarn, net and weave.

13. A method of preparing a polymeric material impregnated with a 4-trifluoromethylnicotinamide mixture as defined in claim 1, which material is useful for making substrate or non-living material for causing knockdown or blood feed inhibition of a dipteran or cimicidae insect pest, such as threads, fibres, yarns, pellets, nets and weaves, which method comprises mixing a polymer with a 4-trifluoromethylnicotinamide mixture as defined in claim 1 at a temperature between 120 to 250 C.

14. A method for mosquito vector-control by knockdown or blood feed inhibition which method comprises (a) applying a knockdown or blood feed inhibiting effective amount of a liquid composition comprising a 4-trifluoromethylnicotinamide mixture as defined in claim 1, and a polymeric binder, and optionally, one or more other synergists, to a surface of a dwelling; and/or (b) placing a substrate or non-living material incorporated with said at least one said 4-(trifluoromethyl)pyridine compound, and optionally an additive, one or more other insecticides, and/or synergists, within a dwelling.

15. A net incorporated with a 4-trifluoromethylnicotinamide mixture as defined in claim 1 having a biological activity in accordance with the WHOPES guidelines of a knockdown after 60 minutes of between 95 percent and 100 percent and/or a mortality after 24 hours of between 80 percent and 100 percent after 20 washes.

16. An insecticidal composition comprising an insecticidally effective amount of a a 4-trifluoromethylnicotinamide mixture as defined in claim 1.

Description

EXAMPLES

Biology Examples

Examples Anopheles stephensi (Indian Malaria Mosquito)

[0225] The individual wells of twelve (12) well tissue culture plates were treated with 200 l of an ethanol solution containing a test compound of Table 1 or Table 2 at a defined concentration and repeated with also 200 l of an ethanol solution containing in addition 2 ppm TFNA-AM. Once the deposits were dry, five non-blood fed adult female Anopheles stephensi (between two to five day old) were added to each well, and sustained with a 10% sucrose solution in a cotton wool plug. Assessment of the knockdown after 1 hour, and mortality after 24 and 48 hours was carried out.

[0226] In case of multiple tests, the mean value is reported. Results are shown in the Table 3 below:

TABLE-US-00003 TABLE 3 without TFNA-AM with TFNA-AM mortality % mortality % Rate Knock Knock Compound ppm Down 24 48 Down 24 48 TFNA-AM 2 75.5 18.3 11.7 Ethanol Control 0.0 3.1 5.9 Abamectin 200 47 100 100 100 100 100 20 7 53 87 100 93 100 2 0 13 33 100 47 53 0.2 0 13 20 100 20 27 Amitraz 200 0 0 0 100 100 100 20 0 0 0 100 20 40 2 0 0 0 100 20 0 0.2 0 0 0 100 20 0 Malathion 20 40 100 100 100 100 100 2 40 100 100 100 100 100 0.2 20 0 0 100 0 0 0.02 20 0 0 100 0 0 Cypermethrin 20 100 100 100 100 100 100 2 100 100 100 100 100 100 0.2 0 0 40 100 100 100 0.02 0 0 20 100 80 20 Bendiocarb 20 100 100 100 100 100 100 2 100 100 100 100 100 100 0.2 20 60 60 100 100 100 0.02 0 0 0 100 20 60 Bifenthrin 20 100 100 100 100 100 100 2 100 100 100 100 100 100 0.2 20 100 100 100 100 100 0.02 20 20 60 100 100 100 Broflanilide 200 0 100 100 87 100 100 20 0 100 100 93 100 100 2 0 100 100 100 100 100 0.2 0 0 20 100 87 93 Cyromazine 200 0 0 0 100 80 40 20 0 0 0 100 60 40 2 0 0 0 100 20 0 0.2 0 0 0 100 20 0 Dicofol 200 0 0 0 100 100 100 20 0 0 0 100 80 100 2 0 0 0 100 60 20 0.2 0 0 0 100 20 0 Diflumetorim 200 100 100 100 100 100 100 20 100 100 100 100 100 100 2 30 60 60 100 90 90 0.2 0 0 0 100 20 10 Etoxazole 200 0 0 0 100 80 80 20 0 0 0 100 60 60 2 0 0 0 100 60 40 0.2 0 0 0 100 40 40 Etofenprox 20 60 100 100 100 100 100 2 0 80 80 100 100 100 0.2 0 20 20 100 100 100 0.02 0 0 0 100 60 60 d-d, trans 20 0 40 60 100 100 100 cyphenothrin 2 0 0 0 100 100 100 0.2 0 0 0 100 60 100 0.02 0 0 0 100 60 20 Fenitrothion 20 0 100 100 100 100 100 2 0 100 100 100 100 100 0.2 0 20 100 100 80 100 0.02 0 0 0 100 40 40 Fipronil 20 0 100 100 100 100 100 2 0 40 100 100 80 100 0.2 0 20 40 100 60 100 0.02 0 0 20 100 0 0 Fluazinam 200 20 90 90 100 100 100 20 20 70 80 100 100 100 2 0 0 0 100 30 20 0.2 0 0 0 100 30 20 Thiamethoxam 200 0 80 80 100 100 100 20 0 60 40 100 60 100 2 0 40 40 100 60 100 0.2 0 0 0 100 20 40 Imidacloprid 200 40 40 60 100 100 100 20 0 20 60 100 100 100 2 0 20 20 100 100 100 0.2 0 0 0 100 20 0 Clothianidin 200 0 0 20 100 100 100 20 0 0 20 100 100 100 2 0 0 0 100 100 100 0.2 0 0 0 100 20 0 Dinotefuran 200 40 100 100 100 100 100 20 0 40 80 100 100 100 2 0 40 40 100 80 60 0.2 0 0 0 100 80 60 Spinosad 200 60 40 40 100 100 100 20 40 0 0 100 100 80 2 40 0 0 100 100 100 0.2 40 0 0 100 80 100 Fenoxycarb 200 20 0 0 100 80 80 20 20 0 0 100 80 80 2 0 0 0 100 80 80 0.2 0 0 0 100 40 40 Picoxystrobin 200 100 100 100 100 100 100 20 30 90 100 100 100 100 2 0 50 0 100 80 80 0.2 0 0 0 100 30 20 Pyriproxyfen 200 0 0 0 100 80 80 20 0 0 0 100 60 60 2 0 0 0 100 60 60 0.2 0 0 0 100 60 60 Propoxur 20 100 100 100 100 100 100 2 100 100 100 100 100 100 0.2 0 100 100 100 100 100 0.02 0 0 0 100 40 40 Diafenthiuron 200 100 100 100 100 100 100 20 100 0 0 100 100 80 2 100 0 20 100 100 60 0.2 60 0 20 100 60 0 Buprofezin 200 0 0 0 100 80 40 20 0 0 0 100 100 60 2 0 0 0 100 100 60 0.2 0 0 0 100 80 60 Fluacrypyrim 200 0 20 80 100 100 100 20 0 0 0 100 100 100 2 0 0 0 100 80 100 0.2 0 0 0 100 60 40 Metaflumizone 200 0 0 80 100 100 100 20 0 0 0 100 100 100 2 0 0 0 100 100 100 0.2 0 0 0 100 40 60 Flubendiamide 200 0 0 0 100 60 40 20 0 0 0 100 80 40 2 0 0 0 100 80 40 0.2 0 0 0 100 80 40 Azadirachtin 200 0 0 0 100 80 80 20 0 0 0 100 60 40 2 0 0 0 100 20 20 0.2 0 0 0 100 20 20 Compound 48 200 100 100 100 100 100 100 20 100 100 100 100 100 100 2 60 100 100 100 100 100 0.2 20 0 0 100 80 100 Compound 49 200 50 100 100 100 100 90 20 50 100 100 100 100 90 2 0 60 60 100 90 90 0.2 0 0 0 90 50 10 Compound 54 200 100 100 100 100 100 100 20 100 100 100 100 100 100 2 0 60 40 100 100 100 0.2 0 0 0 90 60 10 Sulfoxaflor 200 20 80 100 100 90 100 20 0 70 80 100 70 90 2 0 0 60 100 30 60 0.2 0 0 30 100 0 20 Tebufenpyrad 200 0 73 67 93 100 100 20 0 13 20 93 80 73 2 0 0 0 93 27 13 0.2 0 0 0 93 0 0 Flupyradifurone 200 0 20 30 100 70 90 20 0 0 10 100 50 60 2 0 0 0 100 20 20 0.2 0 0 0 100 10 0 Emamectin 200 0 40 90 100 100 100 benzoate 20 0 40 90 100 100 100 2 0 0 10 100 60 60 0.2 0 0 0 100 30 20 Trifloxystrobin 200 80 0 0 100 100 100 20 70 0 0 100 100 100 2 50 0 0 100 60 70 0.2 0 0 0 100 0 0 Triflumizopyrim 200 0 40 40 100 100 100 20 0 0 10 100 90 100 2 0 0 0 100 50 50 0.2 0 0 0 100 0 0