EDIBLE COMPOSITION FOR ALLEVIATING VISUAL FATIGUE

Abstract

The present invention provides an edible composition for alleviating visual fatigue. The composition comprises in parts by weight 1 to 10 parts of curcuma powder, 1 to 12 parts of whole coffee fruit extract, 1 to 20 parts of phospholipid composite, 1 to 15 parts of DHA, 0.5 to 5 parts of phosphatidylserine, and 0.1 to 5 parts of vitamin C. After one week of trial consumption by the subject, the duration of photopic vision is improved with a significant difference in comparison with that before the trial; after 2 weeks of trial consumption, the overall score of visual fatigue symptoms decreases with a significant difference in comparison with that before the trial; after 8 weeks of trial consumption by the subject, the vision field thereof is remarkably enlarged, indicating the formulation may prevent the occurrence of glaucoma. The coffee extract combined with the remaining ingredients has a synergistic effect.

Claims

1. An edible composition, comprising in parts by weight: TABLE-US-00017 curcuma powder 1 to 10 parts; whole coffee fruit extract 1 to 12 parts; phospholipid composite 1 to 20 parts; DHA 1 to 15 parts; phosphatidylserine 0.5 to 5 parts; vitamin C 0.1 to 5 parts.

2. The edible composition according to claim 1, wherein the active ingredients in the whole coffee fruit extract include 20% to 50% of total chlorogenic acids and 0.5% to 5% of proanthocyanidin, with respect to 100% by mass of the whole coffee fruit extract; wherein the total chlorogenic acids include neochlorogenic acid, and the neochlorogenic acid is present in the whole coffee fruit extract in an amount of 1% to 20%.

3. The edible composition according to claim 1, wherein the active ingredients in the phospholipid composite comprise 5% to 5.5% of phosphatidyl ethanolamine, 4% to 5.5% of phosphatidylcholine, 0.5% to 1.8% of phosphatidylinositol, and 1.5% to 2.5% of ceramide, with respect to 100% by mass of the phospholipid composite.

4. The edible composition according to claim 1, wherein the composition consists of the curcuma powder, the whole coffee fruit extract, the phospholipid composite, the DHA, the phosphatidylserine, and the vitamin C.

5. The edible composition according to claim 1, comprising in parts by weight: TABLE-US-00018 curcuma powder 8 parts; whole coffee fruit extract 10 parts; phospholipid composite 10 parts; DHA 7 parts; phosphatidylserine 2 parts; vitamin C 1 part.

6. Use of the edible composition according to claim 1 in the manufacture of a food product having an effect in alleviating visual fatigue or preventing glaucoma.

7. The use according to claim 6, wherein the food product comprises an effective amount of the edible composition according to claim 1.

8. The use according to claim 7, wherein the food product further comprises an excipient.

9. The use according to claim 8, wherein the excipient includes one or more of sorbitol, maltodextrin, magnesium stearate, lactose, and whole milk powder.

10. The use according to claim 8, wherein the food product is present in a form of a tablet, a capsule, powder, or a granule.

11. A food product comprising: TABLE-US-00019 curcuma powder 1% to 10%; whole coffee fruit extract 1% to 12%; phospholipid composite 1% to 20%; DHA 1% to 15%; phosphatidylserine 0.5% to 5%;   vitamin C 0.1% to 5%    with respect to 100% by the total mass of the food product.

12. The food product according to claim 11 comprising: TABLE-US-00020 curcuma powder 8%; whole coffee fruit extract 10%;  phospholipid composite 10%;  DHA 7%; phosphatidylserine 2%; vitamin C 1%  with respect to 100% by the total mass of the food product.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0033] FIG. 1 shows a comparative diagram of the change in the vision field of the subjects before and after the consumption of the compositions in various groups in Example 1 according to the invention.

DETAILED DESCRIPTION OF INVENTION

[0034] For a better understanding of the technical features, objectives and advantageous effects of the present invention, detailed description of the technical solutions of the invention are hereinafter provided, which, however, cannot be construed as limitation to the implementable scope of the present invention. The raw materials in the following examples are obtained from conventional commercial products unless otherwise specified.

Example 1

[0035] This example provides an edible composition for alleviating visual fatigue comprising in parts by weight:

TABLE-US-00005 curcuma powder 8 parts; whole coffee fruit extract 10 parts; phospholipid composite 10 parts; DHA 7 parts; phosphatidylserine 2 parts; vitamin C 1 part; sorbitol 30 parts; magnesium stearate 3 parts; lactose 20 parts; whole milk powder 9 parts.

[0036] Here, the content of the curcumin in the curcuma powder is about 20% to 30%. In the whole coffee fruit extract, the content of the total chlorogenic acids is about 30% to 40%, with a neochlorogenic acid content of about 10% to 20% and a proanthocyanidin content of about 1% to 5%. In the phospholipid composite, the content of phosphatidylethanolamine is about 5% to 5.5%, the content of phosphatidylcholine is about 4% to 5.5%, the content of phosphatidylinositol is about 0.5% to 1.8%, and the content of ceramide is about 1.5% to 2.5%.

[0037] The preparation process for the composition was as follows: curcuma powder, whole coffee fruit extract (obtained by subjecting coffee fruit to extracting with an aqueous solution of ethanol, concentrating and drying), phospholipid composite (purchased from Lecico GmbH), DHA, phosphatidylserine, vitamin C, sorbitol, magnesium stearate, lactose, and whole milk powder were weighed in the proportions by weight, evenly mixed and tableted, to prepare an edible composition for alleviating visual fatigue.

[0038] The composition prepared in this example was given to subjects for trial consumption (with a consumption amount of 4.8 g/day), and a placebo group was used as the control group (in addition to the same excipients and the contents thereof, the 6 active ingredients were replaced with maltodextrin in an equivalent content). The change in the duration of photopic vision and the change in the total score of visual fatigue symptoms were investigated in various groups. The results are shown below:

TABLE-US-00006 TABLE 1 Group with the composition of Placebo group Example 1 Groups (n = 7) (n = 9) Duration of 0 w 63.13 ± 8.71 60.74 ± 14.18  photopic 1 w 57.70 ± 8.95 69.55 ± 14.61.sup.ab  vision (%) 2 w 60.09 ± 6.56 73.24 ± 10.45.sup.AB 3 w  58.45 ± 16.51 74.80 ± 12.54.sup.Ab  4 w 60.05 ± 4.64 73.88 ± 13.16.sup.Ab  5 w 61.34 ± 7.17 75.52 ± 10.61.sup.AB 6 w  55.04 ± 12.69 77.93 ± 9.92.sup.AB  7 w 56.83 ± 9.62 75.62 ± 12.86.sup.AB 8 w  53.53 ± 8.92.sup.a 74.72 ± 11.15.sup.AB Note: A—compared with value before trial, P < 0.01; a—compared with value before trial, P < 0.05; B—compared with the placebo group, P < 0.01, b—compared with the placebo group, P < 0.05.
The same symbols apply to the tables hereinbelow.

TABLE-US-00007 TABLE 2 Group with the composition of Placebo group Example 1 Groups (n = 7) (n = 9) Total score of 0 w 6.43 ± 6.63 6.22 ± 4.63  visual fatigue 1 w 3.00 ± 1.63 4.63 ± 3.38  symptoms 2 w 2.83 ± 2.04 4.11 ± 3.10.sup.a  3 w 2.43 ± 1.27 3.67 ± 3.16.sup.a  4 w 2.57 ± 1.27 2.88 ± 3.14.sup.A 5 w 2.17 ± 0.41 2.63 ± 2.83.sup.A 6 w 2.57 ± 1.27 2.00 ± 2.35.sup.A 7 w 2.43 ± 0.98 2.22 ± 2.54.sup.A 8 w 1.86 ± 1.35 2.22 ± 2.22.sup.A

[0039] It can be seen from Tables 1 and 2 that there is no statistically significant difference in terms of the duration of photopic vision and the total score of visual fatigue symptoms in the subjects before the trial consumption, and therefore were comparable between the groups. After 8 weeks of trial consumption, for the placebo group, the comparison in the duration of photopic vision and the total score of visual fatigue symptoms before and after the trial shows no statistical significance (P>0.05). For the group with the composition of Example 1, the duration of photopic vision tends to increase, with a significant difference after one week of trial consumption, as compared to both that before the trial and that of the placebo group, and duration of photopic vision in the group with the composition of Example 1 was increased by more than 10%. Further, the total score of visual fatigue symptoms in the group with the composition of Example 1 decreases with a significant difference as compared to that before the trial (P<0.05). Thus, the composition of Example 1 is advantageous in alleviating visual fatigue.

[0040] In addition, early symptom of glaucoma is manifested in the shrinkage of the vision field. As seen from FIG. 1, after 8 weeks of consumption of the composition of Example 1, the vision field of the subjects were remarkably enlarged, indicating the formulation may prevent the occurrence of glaucoma.

Example 2

[0041] This example provides an edible composition for alleviating visual fatigue comprising in parts by weight:

TABLE-US-00008 curcuma powder 10 parts; whole coffee fruit extract 12 parts; phospholipid composite 20 parts; DHA 15 parts; phosphatidylserine 5 parts; vitamin C 5 part; sorbitol 20 parts; magnesium stearate 3 parts; lactose 5 parts; whole milk powder 5 parts.

[0042] Here, the content of the curcumin in the curcuma powder is about 20% to 30%. In the whole coffee fruit extract, the content of the total chlorogenic acids is about 30% to 40%, with a neochlorogenic acid content of about 10% to 20% and a proanthocyanidin content of about 1% to 5%. In the phospholipid composite, the content of phosphatidylethanolamine is about 5% to 5.5%, the content of phosphatidylcholine is about 4% to 5.5%, the content of phosphatidylinositol is about 0.5% to 1.8%, and the content of ceramide is about 1.5% to 2.5%.

[0043] The preparation process for the composition was as follows: curcuma powder, whole coffee fruit extract (obtained by subject coffee fruit to extracting with an aqueous solution of ethanol, concentrating and drying), phospholipid composite (purchased from Lecico GmbH), DHA, phosphatidylserine, vitamin C, sorbitol, magnesium stearate, lactose, and whole milk powder were weighed in the proportions by weight, evenly mixed and tableted, to prepare an edible composition for alleviating visual fatigue.

Example 3

[0044] This example provides an edible composition for alleviating visual fatigue comprising in parts by weight:

TABLE-US-00009 curcuma powder 1 part; whole coffee fruit extract 1 part; phospholipid composite 1 part; DHA 1 part; phosphatidylserine 0.5 part; vitamin C 0.1 part; sorbitol 63.4 parts; magnesium stearate 3 parts; lactose 20 parts; whole milk powder 9 parts.

[0045] Here, the content of the curcumin in the curcuma powder is about 20% to 30%. In the whole coffee fruit extract, the content of the total chlorogenic acids is about 30% to 40%, with a neochlorogenic acid content of about 10% to 20% and a proanthocyanidin content of about 1% to 5%. In the phospholipid composite, the content of phosphatidylethanolamine is about 5% to 5.5%, the content of phosphatidylcholine is about 4% to 5.5%, the content of phosphatidylinositol is about 0.5% to 1.8%, and the content of ceramide is about 1.5% to 2.5%.

[0046] The preparation process for the composition was as follows: curcuma powder, whole coffee fruit extract (obtained by subjecting coffee fruit to extracting with an aqueous solution of ethanol, concentrating and drying), phospholipid composite (purchased from Lecico GmbH), DHA, phosphatidylserine, vitamin C, sorbitol, magnesium stearate, lactose, and whole milk powder were weighed in the proportions by weight, evenly mixed and tableted, to prepare an edible composition for alleviating visual fatigue.

Comparative Example 1

[0047] This comparative example provides an edible composition for alleviating visual fatigue comprising in parts by weight:

TABLE-US-00010 whole coffee fruit extract 10 parts; sorbitol 30 parts; magnesium stearate 3 parts; lactose 20 parts; whole milk powder 9 parts; maltodextrin 28 parts.

[0048] Here, in the whole coffee fruit extract, the content of the total chlorogenic acids is about 30% to 40%, with a neochlorogenic acid content of about 10% to 20% and a proanthocyanidin content of about 1% to 5%.

[0049] The preparation process for the composition was as follows: whole coffee fruit extract (obtained by subjecting coffee fruit to extracting with an aqueous solution of ethanol, concentrating and drying), sorbitol, magnesium stearate, lactose, whole milk powder and maltodextrin were weighed in the proportions by weight, evenly mixed and tableted, to prepare an edible composition for alleviating visual fatigue.

Comparative Example 2

[0050] This comparative example provides an edible composition for alleviating visual fatigue comprising in parts by weight:

TABLE-US-00011 curcuma powder 8 parts; phospholipid composite 10 parts; DHA 7 parts; phosphatidylserine 2 parts; vitamin C 1 part; sorbitol 30 parts; magnesium stearate 3 parts; lactose 20 parts; whole milk powder 9 parts; maltodextrin 10 parts.

[0051] Here, the content of the curcumin in the curcuma powder is about 20% to 30%. In the phospholipid composite, the content of phosphatidylethanolamine is about 5% to 5.5%, the content of phosphatidylcholine is about 4% to 5.5%, the content of phosphatidylinositol is about 0.5% to 1.8%, and the content of ceramide is about 1.5% to 2.5%.

[0052] The preparation process for the composition was as follows: curcuma powder, phospholipid composite (purchased from Lecico GmbH), DHA, phosphatidylserine, vitamin C, sorbitol, magnesium stearate, lactose, whole milk powder and maltodextrin were weighed in the proportions by weight, evenly mixed and tableted, to prepare an edible composition for alleviating visual fatigue.

[0053] As compared to Example 1 of present invention, only one active ingredient, the whole coffee fruit extract, was added in the Comparative Example 1, with an equivalent of the amount of the active ingredient used. As compared to Example 1 of present invention, the whole coffee fruit extract as an active ingredient was not added, but the other 5 active ingredients, curcuma powder, phospholipid composite, DHA, phosphatidylserine, and vitamin C, were added instead. The experimental procedures same as in Example 1 were conducted accordingly. The experimental results are shown in Tables 3 and 4 below.

TABLE-US-00012 TABLE 3 Group with the Group with the composition of composition of Comparative Comparative Placebo group Example 1 Example 2 Groups (n = 5) (n = 6) (n = 7) Duration of 0 w 64.17 ± 13.98 64.00 ± 9.84  67.02 ± 14.15 photopic 1 w 65.49 ± 8.27  64.72 ± 11.08 64.49 ± 13.37 vision (%) 2 w 70.28 ± 13.40 63.70 ± 14.77 61.83 ± 8.52  3 w — — — 4 w 65.14 ± 10.10 68.75 ± 11.80 62.87 ± 10.24 5 w 73.96 ± 9.66  64.77 ± 14.35  71.11 ± 14.81.sup.a 6 w 68.28 ± 12.62 63.52 ± 15.01 71.85 ± 11.17 7 w 73.75 ± 13.42 65.88 ± 10.31 73.61 ± 15.29 8 w 67.78 ± 12.40 67.00 ± 14.07 66.61 ± 15.39 9 w  74.33 ± 16.80.sup.a 65.69 ± 11.55 73.52 ± 11.82

TABLE-US-00013 TABLE 4 Group with the Group with the composition of composition of Comparative Comparative Placebo group Example 1 Example 2 Groups (n = 5) (n = 6) (n = 7) Total score of 0 w 3.60 ± 2.41 4.83 ± 2.64 3.57 ± 2.76 visual fatigue 1 w 3.50 ± 2.8.sup.a   2.83 ± 1.83.sup.A 2.83 ± 2.56 symptoms 2 w 2.80 ± 2.59  3.17 ± 1.94.sup.A 2.20 ± 2.39 3 w — — — 4 w  3.00 ± 2.16.sup.a 3.50 ± 2.65  2.33 ± 2.94.sup.a 5 w 3.25 ± 2.99  3.50 ± 2.07.sup.a 2.67 ± 3.50 6 w  2.80 ± 2.77.sup.a  3.50 ± 1.87.sup.a 2.67 ± 2.58 7 w 3.25 ± 2.75 4.00 ± 2.00 4.50 ± 2.12 8 w 4.50 ± 3.54 3.60 ± 1.67 2.40 ± 2.79 9 w 3.20 ± 3.11 3.50 ± 1.76  1.83 ± 1.83.sup.A

[0054] As seen from Tables 3 and 4, after 9 weeks of trial consumption, there was no obvious change in the duration of photopic vision and the total score of visual fatigues symptoms in the group having the composition of Comparative Example 1 and in the group having the composition of Comparative Example 2; neither was there any significant difference as compared to the placebo group.

Comparative Example 3

[0055] This comparative example provides an edible composition which is different from that of Example 1 by replacing the whole coffee fruit extract with a commercial grape seed extract. The composition comprises in part by weight:

TABLE-US-00014 curcuma powder 8 parts; grape seed extract 10 parts; phospholipid composite 10 parts; DHA 7 parts; phosphatidylserine 2 parts; vitamin C 1 part; sorbitol 30 parts; magnesium stearate 3 parts; lactose 20 parts; whole milk powder 9 parts.

[0056] Here, the content of the curcumin in the curcuma powder is about 20% to 30%. The content of proanthocyanidin in the grape seed extract is 90% or more. In the phospholipid composite, the content of phosphatidylethanolamine is about 5% to 5.5%, the content of phosphatidylcholine is about 4% to 5.5%, the content of phosphatidylinositol is about 0.5% to 1.8%, and the content of ceramide is about 1.5% to 2.5%.

[0057] The preparation process for the composition was as follows: curcuma powder, grape seed extract, phospholipid composite (purchased from Lecico GmbH), DHA, phosphatidylserine, vitamin C, sorbitol, magnesium stearate, lactose, whole milk powder, and maltodextrin were weighed in the proportions by weight, evenly mixed and tableted, to prepare an edible composition for alleviating visual fatigue.

Comparative Example 4

[0058] This comparative example provides an edible composition which is different from that of Example 1 by replacing the whole coffee fruit extract with a commercial blueberry extract. The composition comprises in part by weight:

TABLE-US-00015 curcuma powder 8 parts; blueberry extract 10 parts; phospholipid composite 10 parts; DHA 7 parts; phosphatidylserine 2 parts; vitamin C 1 part; sorbitol 30 parts; magnesium stearate 3 parts; lactose 20 parts; whole milk powder 9 parts.

[0059] Here, the content of the curcumin in the curcuma powder is about 20% to 30%. The content of anthocyanidin in the blueberry extract is 20% or more. In the phospholipid composite, the content of phosphatidylethanolamine is about 5% to 5.5%, the content of phosphatidylcholine is about 4% to 5.5%, the content of phosphatidylinositol is about 0.5% to 1.8%, and the content of ceramide is about 1.5% to 2.5%.

[0060] The preparation process for the composition was as follows: curcuma powder, blueberry extract, phospholipid composite (purchased from Lecico GmbH), DHA, phosphatidylserine, vitamin C, sorbitol, magnesium stearate, lactose, whole milk powder, and maltodextrin were weighed in the proportions by weight, evenly mixed and tableted, to prepare an edible composition for alleviating visual fatigue.

[0061] As compared to Example 1 of the present invention, in Comparative Examples 3 and 4, only the whole coffee fruit extract was replaced with grape seed extract and blueberry extract, respectively, with each extract used in the same amount. The active ingredient proanthocyanidin in the grape seed extract (with a content of ≥90%) was much more than the active ingredient proanthocyanidin in the whole coffee fruit extract of the present invention (with a content of 1% to 5%), and the total chlorogenic acid and neochlorogenic acid, were not included as active ingredients in the whole coffee fruit extract. For the blueberry extract, the active ingredient, anthocyanidin (with a content of ≥20%), was different from the active ingredients in the whole coffee fruit extract of the present invention. According to the experimental procedures of Example 1, the compositions prepared in Comparative Examples 3 and 4 were given to subjects for trial consumption (with a consumption amount of 4.8 g/day), and the change in the duration of photopic vision and the change in the total score of visual fatigue symptoms were investigated in various groups. The experimental results are shown in Table 5 below.

TABLE-US-00016 TABLE 5 Group with the Group with the composition of composition of Comparative Comparative Example 3 Example 4 Groups (n = 8) (n = 8) Duration of 0 w 61.81 ± 12.07 61.56 ± 10.30 photopic vision 1 w 58.21 ± 7.83  63.06 ± 8.90  (%) 2 w 60.35 ± 13.41 61.47 ± 9.55  3 w 56.01 ± 7.67  63.73 ± 13.00 4 w 61.01 ± 10.39 63.89 ± 13.51

[0062] As seen from Table 5, after 4 weeks of trial consumption, there was no obvious change in the duration of photopic vision and the total score of visual fatigues symptoms in the group with the composition of Comparative Example 3 and in the group with the composition of Comparative Example 4. In comparison with regard to Table 1, it can be seen that the duration of photopic vision were significantly improved in the subjects after one week of the consumption of the composition of Example 1.

[0063] Overall, it can be seen that only by consumption of all the active ingredients in the composition of the present invention in the proportions that an effect in alleviating visual fatigue is achieved, whereas the effect in alleviating visual fatigue could hardly achieved by using some of the active ingredients. Further, the effect of the whole coffee fruit extract of the present invention in combination with the remaining five raw materials is better than that of a proanthocyanidin-containing extract such as cranberry extract, blueberry extract, grape seed extract or the like in combination with the remaining five raw materials.