Digestive Tract Capsule Endoscopy Integrated With Photodynamic Diagnosis And Therapy

Abstract

The present invention provides a digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy; the digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy includes an imaging system, a control system, a battery and a communication system, and the imaging system includes a fluorescent camera, diagnosis LED light sources and therapy LED light sources. In the digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy provided by the present invention, it changes a conventional optical image system into a fluorescent image system, which requires no extra equipment and has strong adaptability; the present invention can achieve integrated diagnosis and therapy of human body's internal cavities, e.g., digestive tract and achieve the implementation of photodynamic diagnosis and therapy for one time; the digestive tract capsule endoscopy provided by the present invention can achieve diagnosis/therapy circulation, and can examine the therapeutic process of patients.

Claims

1. A digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy, comprising an imaging system, a control system, a battery and a communication system, wherein, the imaging system comprises a fluorescent camera, diagnosis LED light sources and therapy LED light sources.

2. The digestive tract capsule endoscopy according to claim 1, wherein the imaging system is located on one end of the digestive tract capsule endoscopy, the diagnosis LED light sources and the therapy LED light sources are radially spaced with the fluorescent camera as a center.

3. The digestive tract capsule endoscopy according to claim 2, wherein any two adjacent diagnosis LED light source and the therapy LED light source are spaced by 40-50.

4. The digestive tract capsule endoscopy according to claim 1, wherein the central wavelength of the diagnosis LED light sources is 390-410 nm.

5. The digestive tract capsule endoscopy according to claim 1, wherein the central wavelength of the therapy LED light sources is 620-640 nm.

6. The digestive tract capsule endoscopy according to claim 1, wherein emitting angles of the diagnosis LED light sources and the therapy LED light sources are independently 55-65.

7. The digestive tract capsule endoscopy according to claim 6, wherein secondary optical elements are arranged on surfaces of the diagnosis LED light sources and the therapy LED light sources.

8. The digestive tract capsule endoscopy according to claim 7, wherein the secondary optical elements are lenses.

9. The digestive tract capsule endoscopy according to claim 1, wherein the fluorescent camera is provided with a narrow-band filter, the central wavelength of the narrow-band filter is 397-403 nm, the bandwidth of the narrow-band filter is 30-100 nm; the minimum transmittance T of the narrow-band filter is >92%.

10. The digestive tract capsule endoscopy according to claim 9, wherein the narrow-band filter is fixedly adhered on an outer surface of the fluorescent camera.

11. The digestive tract capsule endoscopy according to claim 2, wherein the central wavelength of the diagnosis LED light sources is 390-410 nm.

12. The digestive tract capsule endoscopy according to claim 3, wherein the central wavelength of the diagnosis LED light sources is 390-410 nm.

13. The digestive tract capsule endoscopy according to claim 2, wherein the central wavelength of the therapy LED light sources is 620-640 nm.

14. The digestive tract capsule endoscopy according to claim 3, wherein the central wavelength of the therapy LED light sources is 620-640 nm.

15. The digestive tract capsule endoscopy according to claim 2, wherein emitting angles of the diagnosis LED light sources and the therapy LED light sources are independently 55-65.

16. The digestive tract capsule endoscopy according to claim 3, wherein emitting angles of the diagnosis LED light sources and the therapy LED light sources are independently 55-65.

17. The digestive tract capsule endoscopy according to claim 15, wherein secondary optical elements are arranged on surfaces of the diagnosis LED light sources and the therapy LED light sources.

18. The digestive tract capsule endoscopy according to claim 16, wherein secondary optical elements are arranged on surfaces of the diagnosis LED light sources and the therapy LED light sources.

19. The digestive tract capsule endoscopy according to claim 17, wherein the secondary optical elements are lenses.

20. The digestive tract capsule endoscopy according to claim 2, wherein the fluorescent camera is provided with a narrow-band filter, the central wavelength of the narrow-band filter is 397-403 nm, the bandwidth of the narrow-band filter is 30-100 nm; the minimum transmittance T of the narrow-band filter is >92%.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0019] FIG. 1 is a schematic diagram of a digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy;

[0020] FIG. 2 is a work flow diagram of the digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy;

[0021] FIG. 3 is a schematic diagram showing the diagnosis and therapy of the digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy.

DETAILED DESCRIPTION

[0022] The present invention provides a digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy, including an imaging system, a control system, a battery and a communication system, where the imaging system includes a fluorescent camera, diagnosis LED light sources and therapy LED light sources.

[0023] In the present invention, the digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy is obtained by improving the imaging system of the existing magnetic-control endoscopic capsule system; in the present invention, the imaging system of the magnetic-control endoscopic capsule system includes a fluorescent camera, diagnosis LED light sources and therapy LED light sources. In the present invention, the imaging system is preferably located on one end of the digestive tract capsule endoscopy. In the present invention, the imaging system preferably includes a fluorescent camera, several diagnosis LED light sources and several therapy LED light sources; the diagnosis LED light sources and the therapy LED light sources are radially spaced preferably with the fluorescent camera as a center. In the present invention, the number of the diagnosis LED light sources and the therapy LED light sources is independently and preferably 3-5, and more preferably 4; any two adjacent diagnosis LED light source and the therapy LED light source are spaced by preferably 40-50, and more preferably 45.

[0024] In the present invention, there is no special limitation to the central wavelength of the diagnosis LED light sources and the therapy LED light sources, any central wavelength of a LED luminescent source capable of achieving diagnosis and therapy is available, and in the present invention, the central wavelength of the diagnosis LED light sources and the therapy LED light sources may be matched and upgraded according to the optical property of commercially available photosensitizers. In detailed implementation process of the present invention, specific to the existing photosensitizers, the central wavelength of the diagnosis LED light sources is preferably 390-410 nm, and more preferably 400 nm; the central wavelength of the diagnosis LED light sources is preferably 620-640 nm, and more preferably 630 nm.

[0025] In the present invention, emitting angles of the diagnosis LED light sources and the therapy LED light sources are independently and preferably 55-65, and more preferably 60; in the present invention, emitting angles of the diagnosis LED light sources and the therapy LED light sources are preferably achieved by setting secondary optical element on the surface thereof. In the present invention, the secondary optical element is preferably a lens; there is no special limitation to the source and specification of the lens in the present invention, in detailed implementation process of the present invention, the lens is preferably customized from the manufacturer of the LED luminescent sources, and the manufacturer machines the lens with corresponding numerical value and texture on the surface of LED chips directly during LED packaging, so that the emitting angles of the LED luminescent sources are 55-65.

[0026] In the present invention, the fluorescent camera is preferably provided with a narrow-band filter, and the narrow-band filter is preferably fixedly adhered on an outer surface of the fluorescent camera. In the present invention, the central wavelength of the narrow-band filter is preferably 397-403 nm, the bandwidth of the narrow-band filter is preferably 30-100 nm; the minimum transmittance T of the narrow-band filter is preferably >92%. In the present invention, the narrow-band filter serves to filter out the exciting light of photodynamic diagnosis PDD, and only allows fluorescence generated by stimulation to pass through and to be captured by a camera.

[0027] In the present invention, there is no special limitation to the control system, battery and the communication system of the digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy as long as a control system, a battery and a communication system of an existing digestive tract capsule endoscopy are taken available. In detailed implementation process of the present invention, the existing digestive tract capsule endoscopy is a magnetic-control capsule gastroscope system robot product produced by Anhan Optoelectronic Technology (Wuhan) Co., Ltd.; the product and product structure are specifically referring to a Chinese patent CN201310275948.3. The solution of the present invention mainly aims at an illuminating system and an image capture camera of the capsule endoscopy, and does not involve other parts of the digestive tract capsule endoscopy, such as a capsule shell, an optoelectronic switch device, an image information processing circuit, a radio frequency transmission device, a power unit, a magnetic field sensor, a small magnet; the above parts are not limited by the present invention as long as the structure or component capable of achieving related functions in the field is taken available.

[0028] The technical solution provided by the present invention will be described in detail in connection with the following embodiments, but they should not be construed as a limitation to the claimed scope of the present invention.

Embodiment 1

[0029] Digestive Tract Capsule Endoscopy Integrated with Photodynamic Diagnosis and Therapy

[0030] The capsule endoscopy includes an imaging system, a control system, a battery and a communication system, and the imaging system includes a fluorescent camera, diagnosis LED light sources and therapy LED light sources.

[0031] The concrete structure is shown in the left of FIG. 1, where 1 denotes diagnosis LED light sources, 2 denotes therapy LED light sources, 3 denotes fluorescent camera, 4 denotes control system, 5 denotes battery and 6 denotes communication system. The positional relation of the fluorescent camera, diagnosis LED light sources and therapy LED light sources is shown in the right of FIG. 1, the diagnosis LED light sources and the therapy LED light sources are radially spaced with the fluorescent camera as a center; the number of diagnosis LED light sources and therapy LED light sources is respectively 4, and the interval angles are 45.

[0032] A fluorescent camera is arranged in a front end of the endoscope, a 400 nm-central wavelength narrow-band filter is fixedly adhered on an outer surface of the camera, bandwidth is 30 nm; minimum transmittance: T>92%; the narrow-band filter may filter out PDD exciting light, and only allow fluorescence generated by stimulation to pass through and to be captured by a camera.

[0033] The structure of other parts, namely, control system, battery and communication system are referring to the records of the Chinese patent CN201310275948.3.

Embodiment 2

[0034] The digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy in Embodiment 1 is applied in photodynamic diagnosis and therapy.

[0035] The integrated diagnosis and therapy process of stomach cancer is set as an example, and the workflow is shown in FIG. 2:

[0036] (1) a suspected stomach cancer patient did not take food at least 8 h before receiving therapy;

[0037] (2) a photosensitive drug (e.g., HPD, 5 mg/kg body weight) was injected to make the photosensitive drug enriched in tumor tissues;

[0038] (3) the stomach cancer patient fetched and took the therapy capsule with 1.5-2 L water;

[0039] (4) 1.5-2 L water made stomach full, so that diagnosis and therapy were completed smoothly;

[0040] (5) a physician turned on PDD diagnosis LED and probed the stomach by a magnetic control system;

[0041] (6) the capsule was suspended after finding a fluorescence enhancement region (tumor tissues);

[0042] (7) the physician turned off diagnosis LED and turned on PDT therapy LED to irradiate lesions (power density was 20 mW/cm2 and irradiation time was 20-50 min), photochemical reaction performed between the therapy light and the enriched photosensitive drug to generate singlet oxygen toxicant to cells, thus killing tumor cells purposefully;

[0043] (8) at the end of therapy, the internal electric source of the capsule exhausted, and the capsule would be discharged through small intestine, large intestine and anus within 1-2 d;

[0044] (9) after finishing the primary therapy, the physician may select a proper day to pre-probe and treat lesions by the diagnosis and therapy integrated capsule once again, thus achieving healing, and tumor cells were not found by tissue biopsy.

[0045] The schematic diagram of the diagnosis and therapy of the digestive tract capsule endoscopy integrated with photodynamic diagnosis and therapy is shown in FIG. 3, of which 1 denotes PDD diagnosis LED light sources; 2 denotes fluorescence emitted by tumor tissues; 3 denotes tumor tissues; 4 denotes PDT therapy LED light sources.

[0046] The foregoing descriptions are only preferred implementation manners of the present invention. It should be noted that for a person of ordinary skill in the art, several improvements and modifications may further be made without departing from the principle of the present invention. These improvements and modifications should also be deemed as falling within the protection scope of the present invention.