STABILISED MULTIPLE EMULSIONS AS SKIN PROTECTION PRODUCT

Abstract

The invention relates to stabilised multiple emulsions comprising the compounds a), b) and c), methods for the stabilisation of multiple emulsions and the use of multiple emulsions as skin protection products, in particular for protection against aqueous noxa, where: a) at least one aliphatic unbranched diol with 2 to 4 carbon atoms in the hydrocarbon chain, b) at least one further branched or unbranched aliphatic diol with 4 to 12 carbon atoms in the hydrocarbon chain that is different from a), whereby the hydrocarbon chain may be interrupted by an oxygen atom, c) at least one single-value aliphatic alcohol with 12 to 30 carbon atoms in the hydrocarbon chain.

Claims

1-15. (canceled)

16. A method for stabilizing a skin protection agent multiple emulsion comprising the steps of: a) preparing a stabilization combination by combining i) from 0.2 to 10% w/w of at least one diol selected from 1,2-propanediol, 1,3-propanediol, 1,2-ethanediol, 1,2-butanediol, 1,3-butanediol, and/or 1,4-butanediol; ii) from 0.1 to 1.5% w/w of at least one aliphatic diol having 6 to 12 carbon atoms in the hydrocarbon chain, wherein the at least one aliphatic diol is branched or unbranched and comprises at least one of ethylhexyl glycerine or 1,2-octanediol; iii) from 1.5 to 5% w/w of at least one alcohol selected from lauryl alcohol, cetyl alcohol, stearyl alcohol, ceryl alcohol and/or myricyl alcohol; and iv) optionally, from 0.3 to 2% w/w of at least one further compound having one OH function and at least one unsaturated hydrocarbon ring with 6, 7 or 8 carbon atoms in the ring, wherein the further compound comprises at least one of phenoxyethanol and/or bisabolol; b) forming a water-in-oil-in-water multiple emulsion by combining from 1 to 25% w/w of an emulsifier mixture consisting of a combination of polyolpoly-12-hydroxy stearates with an alkyl and/or alkylene glucoside and a fatty alcohol and/or partial glyceride, and possible further co-emulsifiers including at least one ethoxylated dipolyhydroxy stearate; and from 50 to 85% w/w water, with the stabilization combination; wherein the % w/w of each component relates to the total weight of the skin protection agent and the sum of all components totals 100% w/w; wherein the stabilization combination stabilizes the water-in-oil-in-water emulsion to provide a stable skin protection agent.

17. The method of claim 16, wherein component i) is 1,2-propanediol.

18. The method of claim 16, wherein component iii) is cetyl alcohol, stearyl alcohol, or a mixture thereof.

19. The method of claim 16, wherein component i) is used in an amount of 0.5 to 5% w/w.

20. The method of claim 16, wherein component i) is used in an amount of 1 to 2.5% w/w.

21. The method of claim 16, wherein component ii) is used in an amount of 0.3 to 1.5% w/w.

22. The method of claim 16, wherein component iii) is used in an amount of 1.5 to 3% w/w.

23. The method of claim 16, wherein the emulsifier mixture is used in amount of 2 to 15% w/w.

24. The method of claim 16, wherein the water is used in amount of 68 to 78% w/w.

25. The method of claim 16, wherein component (iv) is present in the stabilization combination and comprises bisabolo in an amount of 0.1 to 1.5% w/w.

26. The method of claim 16, wherein the water-in-oil-in-water multiple emulsion further comprises at least one additional component.

27. The method of claim 16, wherein the skin protection agent is free of preservatives, whereby components i), ii), and iii) are not included under the term preservatives.

28. The method of claim 16, wherein the skin protection agent is free of silicones and silicone containing compounds.

29. The method of claim 16, wherein the skin protection agent is free of parabens.

Description

EXAMPLES

[0111] Various W/O/W emulsions were produced and examined with regard to their multiplicity and their storage stability at different temperatures over a period of 6 weeks.

[0112] The multiplicity of drops was examined under the microscope and evaluated in line with the following scale:

TABLE-US-00001 Combination Conc. Multiplicity of components of the components Composition b) in % w/w W/O/W RT 40 C. 4 C. a), b), c) and 1,2-propandiol 1.00% ++ stable stable stable d) 1,2-hexandiol, caprylyl glycol, cetearyl alcohol bisabolol tropolone a), b), c) 1,2-propandiol 1.20% + stable stable stable caprylyl glycol, cetearyl alcohol glycerine a), b), c) 1,2-butandiol 1.20% + stable stable stable glyceryl caprylate, methyl propane diol cetearyl alcohol a), b), c) and 1,3-propandiol 1.00% ++ stable stable stable d) caprylyl glycol, hexylene glycol, cetearyl alcohol phenoxy ethanol a), b), c) 1,2-propandiol 1.00% ++ stable stable stable caprylyl glycol, ethyl hexyl glycerine cetearyl alcohol a), b), c) and 1,2-propandiol 2.00% + Cracks in 3 phases grainy, liquid d) caprylyl glycol, the product, on surface ethyl hexyl first oil glycerine, formation cetearyl alcohol alpha- tocopherol a), b), c) and 1,2-propandiol 1.00% +++ stable stable stable d) ethyl hexyl glycerine, cetearyl alcohol tocopherol phenoxy ethanol, a), b), c) and 1,2-propandiol 1.00% + stable stable stable d) caprylyl glycol, 1,2-hexanediol, cetearyl alcohol methylbenzyl alcohol a), b), c) and 1,2-propandiol 1.00% + stable stable stable d) ethyl hexyl glycerine, cetearyl alcohol alpha- tocopherol a), b), c) and ethyl hexyl 1.10% + stable stable stable d) glycerine lauryl alcohol, phenethyl alcohol, alpha- tocopherol a), b), c) and 1,2-ethandiol 1.50% +++ stable Slight Slight d) Caprylyl glycol, separation at separation at cetearyl alcohol bottom top phenoxy ethanol, glycerine c) cetearyl alcohol stable stable stable (Comparison trial) a) and b) 1,2-propandiol, 1.00% stable Separates, stable (comparison caprylyl glycol liquid at trial) bottom b), c), and d) methyl 1.50% stable Liquid Liquid (comparison propandiol, separation separation trial) glyceryl, on the on the caprylate surface surface cetearyl alcohol phenethyl alcohol a) and c) 1,2-propandiol, stable stable stable (comparison cetearyl alcohol trial) almost none or none of the drops show multiplicity + the majority of the drops show multiplicity ++ almost all of the drops show multiplicity +++ all of the drops show multiplicity

[0113] The comparison trials clearly show that only those skin protection agents according to the invention that comprise the components a), b) and c) will result in multiple W/O/W emulsions that are also stable. The absence of at least one of the components will result either in emulsions that are not multiple, and thus immediately disintegrate into a W/O or O/W emulsion and/or into skin protection agents that are less stable during storage.