Device and method for extracorporeal blood treatment

Abstract

A device for extracorporeal blood treatment includes a balancing system and calculates an ultrafiltration volume (UF.sub.D) as a volume withdrawal on the basis of a pressure difference (.sub.P) and a temperature difference (.sub.T) at an inlet and an outlet of at least two balance chambers. To this end, pressure sensors are arranged directly behind an inlet and an outlet of the at least two balance chambers, respectively, and determine a fluid pressure at their respective position, and temperature sensors are arranged at inputs of the at least two balance chambers and determine a temperature in the inlet and the outlet of the balance chamber. The ultrafiltration volume (UD.sub.F) is calculated using the pressure difference (.sub.P) established on the basis of fluid pressure values determined by the pressure sensors, and the temperature difference (.sub.T) established on the basis of temperature values determined by the temperature sensors.

Claims

1. A device for extracorporeal blood treatment, the device comprising: a balancing system including at least two balancing chambers; a first pressure sensor arranged at an inlet of each of the at least two balance chambers and a second pressure sensor arranged at an outlet of each of the at least two balance chambers, the first pressure sensor and the second pressure sensor configured to determine a fluid pressure at their position; a first temperature sensor and a second temperature sensor at inputs of the at least two balance chambers, the first temperature sensor and the second temperature sensor being arranged to determine a temperature in the inlet and the outlet of each of the at least two balance chambers; and a calculation device for calculating an ultrafiltration volume using a pressure difference established based on fluid pressure values determined by the first pressure sensor and the second pressure sensor, and a temperature difference based on temperature values determined by the first temperature sensor and the second temperature sensor, the calculation device arranged to calculate the ultrafiltration volume as a volume withdrawal based on the pressure difference and the temperature difference at the inlet and the outlet of each of the at least two balance chambers of the balancing system, wherein the calculation of the volume withdrawal is carried out based on the following formula:
UF.sub.D=a*.sub.P*DF.sub.F+b*.sub.T*DF.sub.F, wherein UF.sub.D is the ultrafiltration volume, .sub.P is the pressure difference, .sub.T is the temperature difference, a and b are coefficients, and DF.sub.F is a dialysis liquid volume.

2. The device for extracorporeal blood treatment according to claim 1, in which an ultrafiltration pump is omitted or arranged such that said ultrafiltration pump is bypassed.

3. The device for extracorporeal blood treatment according to claim 1, further comprising: a first proportional valve and a second proportional valve arranged to control a pressure difference required for reaching a volume withdrawal by continuously adjusting a pressure at each of the positions of the first pressure sensor and the second pressure sensor.

4. The device for extracorporeal blood treatment according to claim 3, wherein the first proportional valve and the second proportional valve are dynamically controllable.

5. The device for extracorporeal blood treatment according to claim 1, further comprising: at least one of a heating element or a cooling element arranged in the outlet of the balance chambers for at least one of creating or controlling a targeted temperature difference between the balance chamber inlet and balance chamber outlet.

6. The device for extracorporeal blood treatment according to claim 1, wherein the pressure difference and the temperature difference are proportional to the ultrafiltration volume.

7. A method for calculating an ultrafiltration volume as a volume withdrawal in a device for extracorporeal blood treatment including a balancing system comprising at least two balancing chambers, the method comprising the steps of: measuring a first pressure at an inlet of each of the at least two balance chambers using a first pressure sensor arranged at the inlet; measuring a second pressure at an outlet of each of the at least two balance chambers using a second pressure sensor arranged at the outlet; measuring a first temperature at the inlet of each of the at least two balance chambers using a first temperature sensor arranged at the inlet; measuring a second temperature at the outlet of each of the at least two balance chambers using a second temperature sensor arranged at the outlet; and calculating the ultrafiltration volume based on a pressure difference and a temperature difference at the inlet and the outlet of the at least two balance chambers of the balancing system, wherein the calculation of the volume withdrawal is carried out based on the following formula:
UF.sub.D=a*.sub.P*DF.sub.F+b*.sub.T*DF.sub.F, wherein UF.sub.D is the ultrafiltration volume, .sub.P is the pressure difference, .sub.T is the temperature difference, a and b are coefficients, and DF.sub.F is a dialysis liquid volume.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) The invention is best understood from the following detailed description when read in connection with the accompanying drawings. Included in the drawings are the following figures:

(2) FIG. 1 shows a schematic and partial hydraulic chart of a balancing system according to one embodiment, which may be provided in a device for extracorporeal blood treatment;

(3) FIG. 2 schematically shows a characteristic curves diagram of a pressure dependence of an ultrafiltration volume according to the exemplary embodiment; and

(4) FIG. 3 schematically shows a characteristic curves diagram of a temperature dependence of an ultrafiltration volume according to the exemplary embodiment.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

(5) In accordance with FIG. 1, a balancing system or balance chamber system or balancing chamber system for extracorporeal or with an extracorporeal blood treatment according to an exemplary embodiment, which may form part of a device for extracorporeal blood treatment such as a dialysis machine, for instance, comprises a first balance chamber 1 and a second balance chamber 2. A dialyzer is designated with the reference symbol 3. Components of the system shown in FIG. 1 which are known per se and do not have any substantial effect in the context of the invention are not denoted with reference symbols and expediently not described in further detail.

(6) A first pressure sensor 30 (PDA2) and a second pressure sensor 40 (PDE) are arranged directly behind the inlet and outlet of the balance chamber 1, 2 for continuously determining the pressure at their arrangement position or at this respective place.

(7) Further, a first proportional valve 10 (Prop1) and a second proportional valve 20 (Prop2) are arranged to continuously adjust the pressure to therapy requirements (required pressure difference for reaching a volume withdrawal).

(8) The first and the second proportional valve 10, 20 replace known constant pressure valves and can be controlled in a dynamic manner.

(9) The fluid pressure directly depends on a preset flow rate, on the one hand, and on aging conditions of components such as dialysis liquid filters, on the other hand. In addition, specific pressure alterations on the blood side due to the venous backflow pressure (PV) or the arterial inflow pressure (PBE, pressure at blood entrance) also have a direct effect on the pressure of the dialysis liquid when entering (PDE).

(10) A temperature difference at the two inputs of the balance chamber(s) 1, 2 is determined as well. The temperature difference is established on the basis of a temperature detection with a first temperature sensor 70 (TSDA) and a second temperature sensor 60 (TSD-S).

(11) As illustrated in FIG. 1, the first pressure sensor 30 and the first proportional valve 10 are arranged in a common outlet branch downstream of the balance chambers 1, 2 (greater line thickness), and the second pressure sensor 40 and the second proportional valve 20 are arranged in a common inlet branch (for the inlet of fresh dialysis liquid to the dialyzer 3, equivalent to the outlet branch leading away from the balance chambers 1, 2 and the inlet branch for the fresh dialysis liquid to the dialyzer 3 downstream of the balance chambers 1, 2, finer line thickness). Furthermore, the second temperature sensor 70 is arranged in a common inlet branch upstream of the balance chambers 1, 2 (greater line thickness), and the first temperature sensor 60 is arranged in the same fluid path as the second pressure sensor 40 and the second proportional valve 20 (finer line thickness).

(12) The arrangement of the afore-mentioned components in each of the common branches for both balance chambers 1, 2 results for instance from the fact that the individual balance chambers work cyclically and complementarily with respect to each other (respectively one of the balance chambers receives fresh dialysis liquid and pushes the used dialysis liquid into the outlet with the membrane displacement, and the respectively other balance chamber receives used dialysis liquid and pushes fresh dialysis liquid toward the dialyzer 3 via the membrane displacement) in order to ensure a continuous flow into the dialyzer 3. This is why the pressure sensors 30, 40, the proportional valves 10, 20 and the temperature sensors 60, 70 are arranged in branch sections through which fluid flows from or to both balance chambers 1, 2.

(13) In the outflow of (/to) the balance chamber 1, 2, i.e. downstream of the dialyzer 3, a heating element or a cooling element 50 is further arranged, with which a particular temperature difference required for achieving a certain volume withdrawal can be controlled or adjusted.

(14) A calculation of the volume withdrawal due to the pressure difference and temperature difference is carried out on the basis of the following formula (1):
UF.sub.D=a*.sub.P*DF.sub.F+b*.sub.T*DF.sub.F(1),
wherein UF.sub.D is the ultrafiltration volume, .sub.P is the pressure difference, .sub.T is the temperature difference, a and b are coefficients, and DF.sub.F is a dialysis liquid volume.

(15) The pressure difference .sub.P and the temperature difference .sub.T are proportional to the ultrafiltration volume UF.sub.D, such as schematically illustrated in FIGS. 2 and 3, for example.

(16) A calculation device for carrying out the aforementioned calculation is integrated or realized in hardware and/or software form in processing components of the device, for instance a controlling device, a processor device and the like, and as such not further illustrated.

(17) In other words, required temperature and pressure differences are each adjusted according to the exemplary embodiment via the proportional valves 10, 20 respectively and the heating element and/or cooling element 50 in the outflow with a predetermined control process, and an arising volume withdrawal for the resulting temperature and pressure differences is calculated.

(18) As described above, the control of the pressure-dependent and temperature-dependent volume withdrawal is performed on the basis of a determination of the pressure conditions in front of and behind the balance chamber 1, 2 with a pressure sensor for the pressure of the dialysis liquid when entering (PDE) and a second pressure sensor for the pressure of the dialysis liquid when exiting (PDA2), and on the basis of a determination of the temperature conditions with a configured temperature sensor unit which consists of a temperature sensor (TSD-S) and a further temperature sensor (TSDA) and is installed in the apparatus for extracorporeal blood treatment, such as a dialysis machine, for instance. The above-mentioned pressure sensors 30, 40 allow the determination of the pressure difference in front of and behind the balance chamber.

(19) Further, a proportional valve 10, 20 for pressure control is arranged both in the inflow and the outflow of the balancing chamber, and a heating element or cooling element 50 such as a heat exchanger is provided for controlling the temperature difference in the outflow.

(20) Thus, the previously described balancing system or balance chamber system for extracorporeal blood treatment may do without an ultrafiltration pump, or the latter may be installed and configured such that it can be bypassed at least.

(21) It should be understood that the invention is not limited to the exemplary embodiment described above, but alterations and modifications may be apparent for the person skilled in the art without departing from the outlined scope of the invention.

(22) It is conceivable, for instance, to design the previously described alternative for the determination of the volume withdrawal for existing devices in such a manner that it can be retrofitted with only one ultrafiltration pump and, if need be, with parts of the required sensor and control systems. In this case, it may be sufficient to subsequently install parts of the required sensor and control systems which are not present yet, and to provide a switchable bypass on the ultrafiltration pump.

(23) As described above, a device for extracorporeal blood treatment comprises a balancing system and calculates an ultrafiltration volume (UF.sub.D) as a volume withdrawal on the basis of a pressure difference (.sub.P) and a temperature difference (.sub.T) at an inlet and an outlet of at least two balance chambers (1, 2). To this end, a first pressure sensor (30) and a second pressure sensor (40) are each arranged directly behind an inlet and an outlet of at least two balance chambers (1, 2), respectively, and determine a fluid pressure at their respective position, and a first temperature sensor (60) and a second temperature sensor (70) are arranged at inputs of the at least two balance chambers (1, 2) and determine a temperature in the inlet and the outlet of the balance chamber. The ultrafiltration volume (UD.sub.F) is calculated using the pressure difference (.sub.P) which can be established on the basis of fluid pressure values determined by the first pressure sensor (30) and the second pressure sensor (40), and the temperature difference (.sub.T) which can be established on the basis of temperature values determined by the first temperature sensor (60) and the second temperature sensor (70).