Nasal delivery

Abstract

A delivery device for and method of delivering a dose of substance for systemic uptake to a nasal cavity of a subject. The delivery device includes a nosepiece unit for insertion into a nasal cavity of a subject and an outlet unit which includes at least one nozzle for delivering substance for systemic uptake substantially only to surfaces in one or both of the anterior region and an anterior section of the posterior region of the nasal cavity of the subject. The delivery device also includes a substance supply unit which is operable to deliver a dose of substance to the at least one nozzle.

Claims

1. A substance delivery device for delivering a first substance and a second substance to a nasal cavity of a subject for systemic uptake, the delivery device comprising: a nosepiece for insertion into the nasal cavity of the subject, the nosepiece including an outlet unit comprising: a first nozzle for delivering the first substance; a second nozzle for delivering the second substance; and a posterior nosepiece member configured to obstruct the nasal cavity and partition the nasal cavity into an anterior region and a posterior region, such that the first substance is delivered from the first nozzle to surfaces only in the anterior region and the second substance is delivered from the second nozzle to surfaces only in an anterior portion of the posterior region; and a substance supply unit configured to deliver the first substance to the first nozzle and the second substance to the second nozzle.

2. The delivery device of claim 1, wherein the substance supply unit is breath actuated on exhalation by the subject.

3. The delivery device of claim 1, wherein the substance supply unit is breath actuated on nasal exhalation by the subject.

4. The delivery device of claim 1, wherein the substance supply unit is manually actuated.

5. The delivery device of claim 1, wherein the outlet unit comprises two first nozzles, each of the two first nozzles being arranged so as to direct the first substance to a lateral surface within the anterior region of the nasal cavity.

6. The delivery device of claim 1, wherein the first nozzle is substantially laterally directed so as to direct the first substance to a lateral surface within the anterior region of the nasal cavity.

7. The delivery device of claim 1, wherein the first nozzle is configured to deliver a liquid.

8. The delivery device of claim 1, wherein the first nozzle is configured to deliver a powder.

9. The delivery device of claim 1, wherein the posterior region comprises the region of the nasal cavity posterior of the nasal valve.

10. The delivery device of claim 1, wherein the posterior nosepiece member is configured to close the nasal valve of the subject.

11. The delivery device of claim 1, further comprising: a mouthpiece through which the subject exhales to cause closure of an oropharyngeal velum of the subject.

12. The delivery device of claim 1, wherein the second nozzle is substantially laterally directed so as to direct the second substance to a lateral surface within the anterior portion of the posterior region of the nasal cavity.

13. A method of delivering a first substance and a second substance to a nasal cavity of a subject for systemic uptake, the method comprising: inserting a nosepiece into the nasal cavity of the subject, the nosepiece including an outlet unit having: a first nozzle for delivering the first substance, a second nozzle for delivering the second substance, and a posterior nosepiece member configured to obstruct the nasal cavity and partition the nasal cavity into an anterior region and a posterior region; causing the first substance to be delivered from the first nozzle to surfaces in the anterior region; and causing the second substance to be delivered from the second nozzle to surfaces in an anterior portion of the posterior region.

14. The method of claim 13, wherein the first nozzle is substantially laterally directed so as to direct the first substance to a lateral surface within the anterior region of the nasal cavity.

15. The method of claim 13, wherein the first nozzle is configured to deliver a liquid.

16. The method of claim 13, wherein the first nozzle is configured to deliver a powder.

17. The method of claim 13, wherein the posterior region comprises the region of the nasal cavity posterior of the nasal valve.

18. The method of claim 13, wherein the posterior nosepiece member is configured to close the nasal valve of the subject.

19. The method of claim 13, further comprising: inserting a mouthpiece into a mouth of the subject through which the subject exhales to cause closure of an oropharyngeal velum of the subject.

20. The method of claim 13, wherein the second nozzle is substantially laterally directed so as to direct the second substance to a lateral surface within the anterior portion of the posterior region of the nasal cavity.

Description

(1) Preferred embodiments of the present invention will now be described hereinbelow by way of example only with reference to the accompanying drawings, in which:

(2) FIG. 1(a) schematically illustrates the anatomy of the upper respiratory tract of a human subject;

(3) FIG. 1(b) illustrates the segmentation of a nasal cavity in accordance with a preferred embodiment of the present invention;

(4) FIG. 2 schematically illustrates a nasal delivery device in accordance with a first embodiment of the present invention;

(5) FIG. 3 schematically illustrates the delivery device of FIG. 2 inserted in a nasal cavity of a subject for operation;

(6) FIG. 4 schematically illustrates the delivery device of FIG. 2 during actuation;

(7) FIG. 5 schematically illustrates the delivery device of FIG. 2 following actuation;

(8) FIG. 6 schematically illustrates a nasal delivery device in accordance with a second embodiment of the present invention;

(9) FIG. 7 schematically illustrates the delivery device of FIG. 6 inserted in a nasal cavity of a subject for operation;

(10) FIG. 8 schematically illustrates the delivery device of FIG. 6 during a first actuation phase in which a positive pressure is created in the anterior region by the exhalation breath;

(11) FIG. 9 schematically illustrates the delivery device of FIG. 6 during a second actuation phase in which the substance supply unit is actuated to deliver substance into the anterior region;

(12) FIG. 10 schematically illustrates the delivery device of FIG. 6 following actuation;

(13) FIG. 11 schematically illustrates a nasal delivery device in accordance with a third embodiment of the present invention;

(14) FIG. 12 schematically illustrates the delivery device of FIG. 11 inserted in a nasal cavity of a subject for operation;

(15) FIG. 13 schematically illustrates the delivery device of FIG. 11 during a first actuation phase in which a positive pressure is created in the anterior region by the exhalation breath;

(16) FIG. 14 schematically illustrates the delivery device of FIG. 11 during a second actuation phase in which the substance supply unit is actuated to deliver substance into the anterior region;

(17) FIG. 15 schematically illustrates the delivery device of FIG. 11 following actuation;

(18) FIG. 16 schematically illustrates a nasal delivery device in accordance with a fourth embodiment of the present invention;

(19) FIG. 17 schematically illustrates the delivery device of FIG. 15 inserted in a nasal cavity of a subject for operation;

(20) FIG. 18 schematically illustrates the delivery device of FIG. 16 during actuation;

(21) FIG. 19 schematically illustrates the delivery device of FIG. 16 following actuation;

(22) FIG. 20 schematically illustrates a nasal delivery device in accordance with a fifth embodiment of the present invention;

(23) FIG. 21 schematically illustrates the delivery device of FIG. 20 inserted in a nasal cavity of a subject for operation;

(24) FIG. 22 schematically illustrates the delivery device of FIG. 20 during a first actuation phase in which the second nosepiece member of the nosepiece unit is inflated by the exhalation breath of the subject such as to partition the nasal cavity;

(25) FIG. 23 schematically illustrates the delivery device of FIG. 20 during a second actuation phase in which the substance supply unit is actuated to deliver substance into the anterior region;

(26) FIG. 24 schematically illustrates the delivery device of FIG. 20 following actuation;

(27) FIG. 25 schematically illustrates a nasal delivery device in accordance with a sixth embodiment of the present invention;

(28) FIG. 26 schematically illustrates the delivery device of FIG. 25 inserted in a nasal cavity of a subject for operation;

(29) FIG. 27 schematically illustrates the delivery device of FIG. 25 during actuation;

(30) FIG. 28 schematically illustrates the delivery device of FIG. 25 following actuation;

(31) FIG. 29 schematically illustrates a nasal delivery device in accordance with a seventh embodiment of the present invention;

(32) FIG. 30 schematically illustrates the delivery device of FIG. 29 inserted in a nasal cavity of a subject for operation;

(33) FIG. 31 schematically illustrates the delivery device of FIG. 29 during actuation;

(34) FIG. 32 schematically illustrates the delivery device of FIG. 29 following actuation;

(35) FIG. 33 schematically illustrates a nasal delivery device in accordance with an eighth embodiment of the present invention;

(36) FIG. 34 schematically illustrates the delivery device of FIG. 33 inserted in a nasal cavity of a subject for operation;

(37) FIG. 35 schematically illustrates the delivery device of FIG. 33 during actuation; and

(38) FIG. 36 schematically illustrates the delivery device of FIG. 33 following actuation.

(39) FIGS. 2 to 5 illustrate a nasal delivery device in accordance with a first embodiment of the present invention.

(40) The delivery device comprises a housing 15, a nosepiece unit 17 for fitting in a nasal cavity of a subject through which substance is delivered to the nasal cavity, and a substance supply unit 19 which is actuatable to deliver a metered dose of substance to the nosepiece unit 17.

(41) The nosepiece unit 17 comprises an outlet unit 21 which extends into the nasal cavity into which the nosepiece unit 17 is inserted, a first nosepiece member 23, in this embodiment a frusto-conical element, which is disposed to one, proximal end of the outlet unit 21 and is configured to obstruct, in this embodiment close, the nostril into which the nosepiece unit 17 is inserted, a second nosepiece member 25 which is disposed to the other, distal end of the outlet unit 21 and is configured to obstruct, in this embodiment close, the nasal cavity at a position therealong, in this embodiment at a position corresponding substantially to the nasal valve, such as to partition the nasal cavity into a first, anterior region 27 between the first and second nosepiece members 23, 25, which corresponds in volume to about one-third of the nasal cavity, and a second, posterior region 29, which corresponds in volume to about the remaining two-thirds of the nasal cavity, as illustrated in FIG. 3.

(42) The outlet unit 21 comprises a support member 31, in this embodiment a narrow, elongate element, to which the first and second nosepiece members 23, 25 are supported, and at least one nozzle 35, in this embodiment a plurality of laterally-directed nozzles 35a, b, disposed between the first and second nosepiece members 23, 25 for delivering substance to the anterior region 27 of the nasal cavity.

(43) In this embodiment the nozzles 35a, b are configured to provide an aerosol spray. In an alternative embodiment the nozzles 35a, b could be configured to deliver jets as columns of substance.

(44) In this embodiment the second nosepiece member 25 comprises a resilient element 37, here in the form of an annular skirt, which through its resilience acts to expand to obstruct the nasal cavity in partitioning the same. In an alternative embodiment the resilient element 37 could take the form of laterally-directed wings, which together act to obstruct the nasal cavity in partitioning the same.

(45) In this embodiment the substance supply unit 19 comprises a mechanical delivery pump, in particular a liquid delivery pump or a powder delivery pump, which delivers metered doses of substance on actuation thereof.

(46) In another alternative embodiment the substance supply unit 19 could comprise a dry powder delivery unit which delivers metered doses of substance, as a dry powder, on actuation thereof.

(47) In yet another alternative embodiment the substance supply unit 19 could comprise an aerosol canister which delivers metered volumes of a propellant, preferably a hydrofluoroalkane (HFA) propellant or the like, containing substance, either as a suspension or solution.

(48) In yet another alternative embodiment the substance supply unit 19 could comprise a nebulizer which delivers metered doses of substance, as an aerosol spray, on actuation thereof.

(49) In this embodiment the substance supply unit 19 is a multi-dose unit for delivering a plurality of metered doses of substance. In another embodiment the substance supply unit 19 could be a single-dose unit for delivering a single metered dose of substance.

(50) In this embodiment the substance supply unit 19 is pre-primeable, here by loading a resilient element, and includes an actuation mechanism 41 which, when triggered, releases the resilient element and actuates the substance supply unit 19 to deliver a metered dose of substance through the nozzles 35a, b of the outlet unit 21.

(51) Operation of the delivery device will now be described hereinbelow with reference to FIGS. 3 to 5 of the accompanying drawings.

(52) Referring to FIG. 3, the nosepiece unit 17 is first inserted into one of the nasal cavities of a subject until the first nosepiece member 23 abuts the nares of the nostril, such as sealingly to engage the skin-lined anterior section of the anterior region of the nasal cavity. When inserted, the distal end of the outlet unit 21 extends about 2 cm into the nasal cavity of the subject, which corresponds in position to that of the nasal valve, and the second nosepiece member 25 acts to obstruct the nasal cavity at that point such as to partition the nasal cavity.

(53) Referring to FIG. 4, the subject then actuates the actuation mechanism 41, in this embodiment manually, which acts to actuate the substance supply unit 19 to deliver a metered dose of substance from the nozzles 35a, 35b of the outlet unit 21.

(54) The metered dose of substance, in this embodiment in the form of an aerosol spray, is confined to the anterior region 27 of the nasal cavity as defined between the first and second nosepiece members 23, 25. As described hereinabove, the present inventors have recognized that the systemic uptake of substance as delivered via the nasal cavity is, contrary to current thinking, enhanced where delivered through the anterior region of the nasal cavity, and thus, by confining the delivered dose of substance to the anterior region, an enhanced systemic effect is obtained per unit dose of substance as compared to the conventional delivery of substances into the nasal cavity, such as generally by a nasal spray or nasal drops.

(55) Following actuation, as illustrated in FIG. 5, the nosepiece unit 17 is withdrawn from the nasal cavity of the subject.

(56) In one embodiment, where the delivery device is a single-dose device, ti device can be discarded.

(57) In another embodiment, where the delivery device is a multi-dose device, the device is ready for further use following priming of the substance supply unit 19. In a preferred embodiment, where the nosepiece unit 17 is replaceable, the nosepiece unit 17 can be replaced with a new nosepiece unit 17.

(58) FIGS. 6 to 10 illustrate a nasal delivery device in accordance with a second embodiment of the present invention.

(59) The delivery device of this embodiment is very similar to the delivery device of the above-described embodiment, and thus, in order to avoid unnecessary duplication of description, only the differences will be described in detail.

(60) The delivery device of this embodiment differs from that of the above-described embodiment in that the support member 31 of the outlet unit 21 includes a gas delivery port 45 which is disposed at a position between the first and second nosepiece members 23, 25, and in further comprising a mouthpiece 47 which is fluidly connected to the gas delivery port 45, such that, on exhalation into the mouthpiece 47, an air flow is delivered to the gas delivery port 45 which acts to develop a pressure in the partitioned anterior region 27 as defined between the first and second nosepiece members 23, 25, which acts to expand the anterior region 27 and thereby promote the delivery of substance thereto.

(61) Operation of the delivery device is illustrated in FIGS. 7 to 10 of the accompanying drawings. The operation of the delivery device of this embodiment is the same as that of the above-described embodiment, except in that the subject exhales through the mouthpiece 47 during actuation of the delivery device, in order to cause expansion of the partitioned anterior section.

(62) In one alternative-embodiment the actuation mechanism 41 could be a breath-actuated mechanism, such that the actuation mechanism 41 acts to actuate the substance supply unit 19 on the generation of a predetermined pressure at the mouthpiece 47.

(63) FIGS. 11 to 15 illustrate a nasal delivery device in accordance with a third embodiment of the present invention.

(64) The delivery device of this embodiment is very similar to the delivery device of the above-described embodiment, and thus, in order to avoid unnecessary duplication of description, only the differences will be described in detail.

(65) The delivery device of this embodiment differs from that of the above-described embodiment in that the support member 31 of the outlet unit 21 includes a gas delivery port 45 which is disposed at a position between the first and second nosepiece members 23, 25, and in further comprising a gas supply unit 49, in this embodiment a compressible bulb, which is fluidly connected to the gas delivery port 45 and actuatable to deliver an air flow to the gas delivery port 45 which acts to develop a pressure in the partitioned anterior region 27 as defined between the first and second nosepiece members 23, 25, which acts to expand the anterior region 27 and thereby promote the delivery of substance thereto.

(66) Operation of the delivery device is illustrated in FIGS. 12 to 15 of the accompanying drawings. The operation of the delivery device of this embodiment is the same as that of the above-described embodiment, except in that the subject actuates the gas supply unit 49, in this embodiment by compressing the bulb, during actuation of the delivery device, in order to cause expansion of the partitioned anterior region 27.

(67) FIGS. 16 to 19 illustrate a nasal delivery device in accordance with a fourth embodiment of the present invention.

(68) The delivery device comprises a housing 115, a nosepiece unit 117 for fitting in a nasal cavity of a subject through which substance is delivered to the nasal cavity, and a substance supply unit 119 which is actuatable to deliver a metered dose of substance to the nosepiece unit 117.

(69) The nosepiece unit 117 comprises an outlet unit 121 which extends into the nasal cavity into which the nosepiece unit 117 is inserted, and a nosepiece member 123, in this embodiment a frusto-conical element, which is disposed to one, proximal end of the outlet unit 121 and is configured to obstruct, in this embodiment close, the nostril into which the nosepiece unit 117 is inserted.

(70) The outlet unit 121 comprises a support member 131, in this embodiment a narrow, elongate element, to which the nosepiece member 123 is supported, and at least one nozzle 135, in this embodiment a plurality of laterally-directed nozzles 135a, b, which is disposed such as to deliver substance substantially entirely to the anterior region 137 of the nasal cavity relative to the posterior region of the nasal cavity 139. By configuring the at least one nozzle 135 such as to direct the substance laterally to the surfaces of the anterior region 137 of the nasal cavity, the substance is substantially entirely delivered to the anterior region 137 of the nasal cavity relative to the posterior region 139 of the nasal cavity.

(71) In this embodiment the nozzles 135a, b are configured to provide an aerosol spray. In an alternative embodiment the nozzles 135a, b could be configured to deliver jets as columns of substance.

(72) In this embodiment the substance supply unit 119 comprises a mechanical delivery pump, in particular a liquid delivery pump or a powder delivery pump, which delivers metered doses of substance on actuation thereof.

(73) In another alternative embodiment the substance supply unit 119 could comprise a dry powder delivery unit which delivers metered doses of substance, as a dry powder, on actuation thereof.

(74) In yet another alternative embodiment the substance supply unit 119 could comprise an aerosol canister which delivers metered volumes of a propellant, preferably a hydrofluoroalkane (HFA) propellant or the like, containing substance, either as a suspension or solution.

(75) In yet another alternative embodiment the substance supply unit 119 could comprise a nebulizer which delivers metered doses of substance, as an aerosol spray, on actuation thereof.

(76) In this embodiment the substance supply unit 119 is a multi-dose unit for delivering a plurality of metered doses of substance. In another embodiment the substance supply unit 119 could be a single-dose unit for delivering a single metered dose of substance.

(77) In this embodiment the substance supply unit 119 is pre-primeable, here by loading a resilient element, and includes an actuation mechanism 141 which, when triggered, releases the resilient element and actuates the substance supply unit 119 to deliver a metered dose of substance through the nozzles 135a, b of the outlet unit 121.

(78) In another embodiment the substance supply unit 119 could be manually actuated, for example, by manually depressing or compressing an applicator element.

(79) Operation of the delivery device will now be described hereinbelow with reference to FIGS. 17 to 19 of the accompanying drawings.

(80) Referring to FIG. 17, the nosepiece unit 117 is first inserted into one of the nasal cavities of a subject until the nosepiece member 123 abuts the nares of the nostril, such as sealingly to engage the skin-lined anterior section of the anterior region of the nasal cavity. When inserted, the distal end of the outlet unit 121 extends about 2 cm into the nasal cavity of the subject, which corresponds in position to that of the nasal valve.

(81) Referring to FIG. 18, the subject then actuates the actuation mechanism 141, in this embodiment manually, which acts to actuate the substance supply unit 119 to deliver a metered dose of substance from the nozzles 135a, 135b of the outlet unit 121.

(82) The metered dose of substance, in this embodiment in the form of an aerosol spray, is confined to the anterior region 127 of the nasal cavity. As described hereinabove, the present inventors have recognized that the systemic uptake of substance as delivered via the nasal cavity is, contrary to current thinking, enhanced where delivered through the anterior region 127 of the nasal cavity, and thus, by confining the delivered dose of substance to the anterior region 127, an enhanced systemic effect is obtained per unit dose of substance as compared to the conventional delivery of substances into the nasal cavity, such as generally by a nasal spray or nasal drops.

(83) Following actuation, as illustrated in FIG. 19, the nosepiece unit 117 is withdrawn from the nasal cavity of the subject.

(84) In one embodiment, where the delivery device is a single-dose device, the device can be discarded.

(85) In another embodiment, where the delivery device is a multi-dose device, the device is ready for further use following priming of the substance sup ply unit 119. In a preferred embodiment, where the nosepiece unit 117 is replaceable, the nosepiece unit 117 can be replaced with a new nosepiece unit 117.

(86) FIGS. 20 to 24 illustrate a nasal delivery device in accordance with a fifth embodiment of the present invention.

(87) The delivery device comprises a housing 215, a nosepiece unit 217 for fitting in a nasal cavity of a subject through which substance is delivered to the nasal cavity, a substance supply unit 219 which is actuatable to deliver a metered dose of substance to the nosepiece unit 117, and a mouthpiece unit 2220 through which the subject exhales.

(88) The nosepiece unit 217 comprises an outlet unit 221 which extends into the nasal cavity into which the nosepiece unit 117 is inserted, a first nosepiece member 223, in this embodiment a frusto-conical element, which is disposed to one, proximal end of the outlet unit 221 and is configured to obstruct, in this embodiment close, the nostril into which the nosepiece unit 217 is inserted, a second, expandable nosepiece member 225 which is disposed to the other, distal end of the outlet unit 221 and is configured, when expanded, to obstruct, in this embodiment close, the nasal cavity at a position therealong, in this embodiment at a position corresponding substantially to the nasal valve, such as to partition the nasal cavity into a first, anterior region 227 between the first and second nosepiece members 223, 225, which corresponds in volume to about one-third of the nasal cavity, and a second, posterior region 229, which corresponds in volume to about the remaining two-thirds of the nasal cavity, as illustrated in FIG. 22.

(89) The outlet unit 221 comprises a support member 231, in this embodiment a narrow, elongate element, to which the first and second nosepiece members 223, 225 are supported, and at least one nozzle 235, in this embodiment a plurality of laterally-directed nozzles 235a, b, disposed between the first and second nosepiece members 223, 225 for delivering substance to the anterior region 227 of the nasal cavity.

(90) In this embodiment the nozzles 235a, b are configured to provide an aerosol spray. In an alternative embodiment the nozzles 235a, b could be configured to deliver jets as columns of substance.

(91) In this embodiment the second nosepiece member 225 comprises an inflatable member which is fluidly connected to the mouthpiece unit 220, such that, on exhalation by the subject through the mouthpiece unit 220, the second nosepiece member 225 is expanded to obstruct the nasal cavity in partitioning the same.

(92) In this embodiment the substance supply unit 219 comprises a mechanical delivery pump, in particular a liquid delivery pump or a powder delivery pump, which delivers metered doses of substance on actuation thereof.

(93) In another alternative embodiment the substance supply unit 219 could comprise a dry powder delivery unit which delivers metered doses of substance, as a dry powder, on actuation thereof.

(94) In yet another alternative embodiment the substance supply unit 219 could comprise an aerosol canister which delivers metered volumes of a propellant, preferably a hydrofluoroalkane (HFA) propellant or the like, containing substance, either as a suspension or solution.

(95) In yet another alternative embodiment the substance supply unit 219 could comprise a nebulizer which delivers metered doses of substance, as an aerosol spray, on actuation thereof.

(96) In this embodiment the substance supply unit 219 is a multi-dose unit for delivering a plurality of metered doses of substance. In another embodiment the substance supply unit 219 could be a single-dose unit for delivering a single metered dose of substance.

(97) In this embodiment the substance supply unit 219 is pre-primeable, here by loading a resilient element, and includes an actuation mechanism 241 which, when triggered, releases the resilient element and actuates the substance supply unit 219 to deliver a metered dose of substance through the nozzles 235a, b of the outlet unit 221.

(98) In this embodiment the actuation mechanism 241 is a manually-actuated unit, but in another embodiment could be a breath-actuated unit which is actuated in response to the generation of a predetermined pressure at the mouthpiece unit 220, which is sufficient to provide for inflation of the second nosepiece member 225.

(99) Operation of the delivery device will now be described hereinbelow reference to FIGS. 21 to 24 of the accompanying drawings.

(100) Referring to FIG. 21, the nosepiece unit 217 is first inserted into one of the nasal cavities of a subject until the first nosepiece member 223 abuts the nares of the nostril, such as sealingly to engage the skin-lined anterior section of the anterior region of the nasal cavity. When inserted, the distal end of the outlet unit 221 extends about 2 cm into the nasal cavity of the subject, which corresponds in position to that of the nasal valve.

(101) Referring to FIG. 22, the subject then exhales through the mouthpiece unit 220, and the exhaled air flow acts to generate a pressure within the second nosepiece member 225, which is inflated such as to obstruct the nasal cavity and thereby partition the anterior and posterior regions 227, 229 of the nasal cavity.

(102) Referring to FIG. 23, the subject then actuates the actuation mechanism 241, in this embodiment manually, which acts to actuate the substance supply unit 219 to deliver a metered dose of substance from the nozzles 235a, 235b of the outlet unit 221.

(103) The metered dose of substance, in this embodiment in the form of an aerosol spray, is confined to the anterior region 227 of the nasal cavity as defined between the first and second nosepiece members 223, 225. As described hereinabove, the present inventors have recognized that the systemic uptake of substance as delivered via the nasal cavity is, contrary to current thinking, enhanced where delivered through the anterior region 227 of the nasal cavity, and thus, by confining the delivered dose of substance to the anterior region 227, an enhanced systemic effect is obtained per unit dose of substance as compared to the conventional delivery of substances into the nasal cavity, such as generally by a nasal spray or nasal drops.

(104) Following actuation, as illustrated in FIG. 24, the nosepiece unit 217 is withdrawn from the nasal cavity of the subject.

(105) In one embodiment, where the delivery device is a single-dose device, the device can be discarded.

(106) In another embodiment, where the delivery device is a multi-dose device, the device is ready for further use following priming of the substance supply unit 219. In a preferred embodiment, where the nosepiece unit 217 is replaceable, the nosepiece unit 217 can be replaced with a new nosepiece unit 217.

(107) In one alternative embodiment the second nosepiece member 225 could instead be mechanically expanded, for example, by expandable arm members.

(108) FIGS. 25 to 28 illustrate a nasal delivery device in accordance with a sixth embodiment of the present invention.

(109) The delivery device comprises a housing 315, a nosepiece unit 317 for fitting in a nasal cavity of a subject through which substance is delivered to the nasal cavity, a substance supply unit 319 which is actuatable to deliver metered doses of first and second substances to the nosepiece unit 317, and a mouthpiece unit 320 through which the subject exhales.

(110) The nosepiece unit 317 comprises an outlet unit 321 which extends into the nasal cavity into which the nosepiece unit 317 is inserted, a first nosepiece member 323, in this embodiment a frusto-conical element, which is disposed to one, proximal end of the outlet unit 321 and is configured to obstruct, in this embodiment close, the nostril into which the nosepiece unit 317 is inserted, a second nosepiece member 325 which is disposed to the other, distal end of the outlet unit 321 and is configured to obstruct, in this embodiment close, the nasal cavity at a position therealong, in this embodiment at a position corresponding substantially to the nasal valve, such as to partition the nasal cavity into a first, anterior region 327 between the first and second nosepiece members 323, 325, which corresponds in volume to about one-third of the nasal cavity, and a second, posterior region 329, which corresponds in volume to about the remaining two-thirds of the nasal cavity, as illustrated in FIG. 26.

(111) The outlet unit 321 comprises a support member 331, in this embodiment a narrow, elongate element, to which the first and second nosepiece members 323, 325 are supported, at least one first, anterior nozzle 335, in this embodiment a plurality of laterally-directed anterior nozzles 335a, b, which is disposed between the first and second nosepiece members 323, 325 for delivering substance, in this embodiment substance for systemic application, to the anterior region 327 of the nasal cavity, and at least one second, posterior nozzle 336, in this embodiment a single, axially-directed nozzle, for delivering substance, in this embodiment substance for topical or CNS application, to the posterior region 329 of the nasal cavity.

(112) In this embodiment the anterior nozzles 335a, b are configured to provide an aerosol spray. In an alternative embodiment the anterior nozzles 335a, b could be configured to deliver jets as columns of substance.

(113) In this embodiment the posterior nozzle 336 is configured to provide an aerosol spray. In an alternative embodiment the posterior nozzle 335 could be configured to deliver a jet as a column of substance.

(114) In this embodiment the second nosepiece member 325 comprises a resilient element 337, here in the form of an annular skirt, which through its resilience acts to expand to obstruct the nasal cavity in partitioning the same. In an alternative embodiment the resilient element 337 could take the form of laterally-directed wings, which together act to obstruct the nasal cavity in partitioning the same.

(115) In this embodiment the substance supply unit 319 comprises a mechanical delivery pump, in particular a liquid delivery pump or a powder delivery pump, which delivers metered doses of first and second substances on actuation thereof.

(116) In another alternative embodiment the substance supply unit 319 could comprise a dry powder delivery unit which delivers metered doses of first and second substances, as dry powders, on actuation thereof.

(117) In yet another alternative embodiment the substance supply unit 319 could comprise an aerosol canister which delivers first and second metered volumes of a propellant, preferably a hydrofluoroalkane (HFA) propellant or the like, each containing substance, either as a suspension or solution.

(118) In yet another alternative embodiment the substance supply unit 319 could comprise a nebulizer which delivers metered doses of first and second substances, as aerosol sprays, on actuation thereof.

(119) In this embodiment the substance supply unit 319 is a multi-dose unit for delivering a plurality of metered doses of first and second substances. In another embodiment the substance supply unit 319 could be a single-dose unit for delivering a single metered dose of first and second substances.

(120) In this embodiment the substance supply unit 319 is pre-primeable, here by loading a resilient element, and includes an actuation mechanism 341 which, when triggered, releases the resilient element and actuates the substance supply unit 319 to deliver metered doses of first and second substances through the respective ones of the anterior nozzles 335a, b and posterior nozzle 336 of the outlet unit 321.

(121) Operation of the delivery device will now be described hereinbelow with reference to FIGS. 26 to 28 of the accompanying drawings.

(122) Referring to FIG. 26, the nosepiece unit 317 is first inserted into one of the nasal cavities of a subject until the first nosepiece member 323 abuts the nares of the nostril, such as sealingly to engage the skin-lined anterior section of the anterior region of the nasal cavity. When inserted, the distal end of the outlet unit 321 extends about 2 cm into the nasal cavity of the subject, which corresponds in position to that of the nasal valve, and the second nosepiece member 325 acts to obstruct the nasal cavity at that point such as to partition the nasal cavity.

(123) Referring to FIG. 27, the subject then actuates the actuation mechanism 341, in this embodiment manually, which acts to actuate the substance supply unit 319 to deliver a metered dose of a first substance, in this embodiment substance for systemic application, from the anterior nozzles 335a, 335b of the outlet unit 321 and a metered dose of a second substance, in this embodiment substance for topical or CNS application, from the posterior nozzle 336 of the outlet unit 321.

(124) The metered dose of the first substance, in this embodiment in the form of an aerosol spray, is confined to the anterior region 327 of the nasal cavity as defined between the first and second nosepiece members 323, 325. As described hereinabove, the present inventors have recognized that the systemic uptake of substance as delivered via the nasal cavity is, contrary to current thinking, enhanced where delivered through the anterior region 327 of the nasal cavity, and thus, by confining the delivered dose of substance to the anterior region 327, an enhanced systemic effect is obtained per unit dose of substance as compared to the conventional delivery of substances into the nasal cavity, such as generally by a nasal spray or nasal drops.

(125) Following actuation, as illustrated in FIG. 28, the nosepiece unit 317 is withdrawn from the nasal cavity of the subject.

(126) In one embodiment, where the delivery device is a single-dose device, the device can be discarded.

(127) In another embodiment, where the delivery device is a multi-dose device, the device is ready for further use following priming of the substance supply unit 319. In a preferred embodiment, where the nosepiece unit 317 is replaceable, the nosepiece unit 317 can be replaced with a new nosepiece unit 317.

(128) FIGS. 29 to 32 illustrate a nasal delivery device in accordance with a seventh embodiment of the present invention.

(129) The delivery device comprises a housing 415, a nosepiece unit 417 for fitting in a nasal cavity of a subject through which substance is delivered to the nasal cavity, a substance supply unit 419 which is actuatable to deliver a metered dose of substance to the nosepiece unit 417, and a mouthpiece unit 420 through which the subject exhales.

(130) The nosepiece unit 417 comprises a body unit 421 which comprises a first nosepiece member 423, in this embodiment a frusto-conical element, which is disposed at one, proximal end and is configured to obstruct, in this embodiment close, the nostril into which the nosepiece unit 417 is inserted, and a second nosepiece member 425 which is disposed to the other, distal end and comprises a flexible, elongate element which is sufficiently compliant extend into, and in one embodiment, through the nasal valve. The second nosepiece member 425 has a shape, size and surface properties which enable the second nosepiece member 425 comfortably to penetrate the nasal valve. In this embodiment, when the nosepiece unit 417 is fully inserted into a nasal cavity, the distal end of the second nosepiece member 425 extends from about 3 cm to about 5 cm into the nasal cavity.

(131) The nosepiece unit 417 further comprises at least one, in this embodiment a plurality of laterally-directed anterior nozzles 435a, b which are configured such as to deliver substance, in this embodiment substance for systemic application, to surfaces within the anterior region of the nasal cavity, and at least one second, posterior nozzle 435, in this embodiment a single, axially-directed nozzle, for delivering the substance to surfaces in an anterior section of the posterior region of the nasal cavity, in this embodiment an anterior third of the posterior region, and a preferred embodiment a mid-anterior third of the posterior region, as illustrated in FIG. 1(b).

(132) In this embodiment the anterior nozzles 435a, b are configured to provide an aerosol spray. In an alternative embodiment the anterior nozzles 435a, b could be configured to deliver jets as columns of substance.

(133) In this embodiment the posterior nozzle 436 is configured to provide an aerosol spray. In an alternative embodiment the posterior nozzle 436 could be configured to deliver a jet as a column of substance.

(134) In this embodiment the substance supply unit 419 comprises a mechanical delivery pump, in particular a liquid delivery pump or a powder delivery pump, which delivers a metered dose of substance on actuation thereof.

(135) In another alternative embodiment the substance supply unit 419 could comprise a dry powder delivery unit which delivers a metered dose of substance, as a dry powder, on actuation thereof.

(136) In yet another alternative embodiment the substance supply unit 419 could comprise an aerosol canister which delivers a metered volume of a propellant, preferably a hydrofluoroalkane (HFA) propellant or the like, containing substance, either as a suspension or solution.

(137) In yet another alternative embodiment the substance supply unit 419 could comprise a nebulizer which delivers a metered dose of substance, as an aerosol spray, on actuation thereof.

(138) In this embodiment the substance supply unit 419 is a multi-dose unit for delivering a plurality of metered doses of substance. In another embodiment the substance supply unit 419 could be a single-dose unit for delivering a single metered dose of substance.

(139) In this embodiment the substance supply unit 419 is pre-primeable, here by loading a resilient element, and includes an actuation mechanism 441 which, when triggered, releases the resilient element and actuates the substance supply unit 419 to deliver a metered dose of substance through the anterior nozzles 435a, b and the posterior nozzle 436. In this embodiment the actuation mechanism 441 is breath actuated in response to exhalation by the subject through the mouthpiece unit 420.

(140) Operation of the delivery device will now be described hereinbelow with reference to FIGS. 30 to 32 of the accompanying drawings.

(141) Referring to FIG. 30, the nosepiece unit 417 is first inserted into one of the nasal cavities of a subject until the first nosepiece member 423 abuts the nares of the nostril, such as sealingly to engage the skin-lined anterior section of the anterior region of the nasal cavity, and the second nosepiece member 425 extends into the nasal valve.

(142) Referring to FIG. 31, the subject then exhales through the mouthpiece unit 420, which exhalation triggers the actuation mechanism 441, which in turn acts to actuate the substance supply unit 419 to deliver a metered dose of substance, in this embodiment substance for systemic application, from the anterior nozzles 435a, 435b and the posterior nozzle 435.

(143) The substance as delivered from the anterior nozzles 435a, b is delivered to surfaces in the anterior region of the nasal cavity, and the substance as delivered from the posterior nozzle 436 is delivered to an anterior section of the posterior region of the nasal cavity, in this embodiment the anterior third of the posterior region of the nasal cavity, and more preferably substantially entirely to the mid-anterior third of the posterior region of the nasal cavity. As described hereinabove, the present inventors have recognized that the systemic uptake of substance as delivered via the nasal cavity is, contrary to current thinking, enhanced where delivered through the anterior region of the nasal cavity and the anterior third of the posterior region of the nasal cavity, and thus, by confining the delivered dose of substance to the anterior region and the anterior third of the posterior region of the nasal cavity, an enhanced systemic effect is obtained per unit dose of substance as compared to the conventional delivery of substances into the nasal cavity, such as generally by a nasal spray or nasal drops.

(144) Following actuation, as illustrated in FIG. 32, the nosepiece unit 417 is withdrawn from the nasal cavity of the subject.

(145) In one embodiment, where the delivery device is a single-dose device, the device can be discarded.

(146) In another embodiment, where the delivery device is a multi-dose device, the device is ready for further use following priming of the substance supply unit 419. In a preferred embodiment, where the nosepiece unit 417 is replaceable, the nosepiece unit 417 can be replaced with a new nosepiece unit 417.

(147) FIGS. 33 to 36 illustrate a nasal delivery device in accordance with an eighth embodiment of the present invention.

(148) The delivery device comprises a housing 515, a nosepiece unit 517 for fitting in a nasal cavity of a subject through which substance is delivered to the nasal cavity, and a substance supply unit 519 which is actuatable to deliver a metered dose of substance to the nosepiece unit 517.

(149) The nosepiece unit 517 comprises a body unit 521 which comprises a first nosepiece member 523, in this embodiment a frusto-conical element, which is disposed at one, proximal end and is configured to obstruct, in this embodiment close, the nostril into which the nosepiece unit 517 is inserted, a second nosepiece member 525 which is disposed to the other, distal end and comprises a flexible, elongate element which is sufficiently compliant to extend into, and in one embodiment, through the nasal valve, and a flow channel 527 which is fluidly connected to an actuation mechanism 541 of the substance supply unit 519, as will be described in more detail hereinbelow.

(150) The nosepiece unit 517 further comprises at least one, in this embodiment a plurality of laterally-directed anterior nozzles 535a, b which are configured such as to deliver substance, in this embodiment substance for systemic application, to surfaces within the anterior region of the nasal cavity, and at least one second, posterior nozzle 536, in this embodiment a single, axially-directed nozzle, for delivering the substance to surfaces in an anterior section of the posterior region of the nasal cavity, in this embodiment an anterior third of the posterior region, and a preferred embodiment a mid-anterior third of the posterior region, as illustrated in FIG. 1(b).

(151) In this embodiment the anterior nozzles 535a, b are configured to provide n aerosol spray. In an alternative embodiment the anterior nozzles 535a, b could be configured to deliver jets as columns of substance.

(152) In this embodiment the posterior nozzle 536 is configured to provide an aerosol spray. In an alternative embodiment the posterior nozzle 536 could be configured to deliver a jet as a column of substance.

(153) In this embodiment the substance supply unit 519 comprises a mechanical delivery pump, in particular a liquid delivery pump or a powder delivery pump, which delivers a metered dose of substance on actuation thereof.

(154) In another alternative embodiment the substance supply unit 519 could comprise a dry powder delivery unit which delivers a metered dose of substance, as a dry powder, on actuation thereof.

(155) In yet another alternative embodiment the substance supply unit 519 could comprise an aerosol canister which delivers a metered volume of a propellant, preferably a hydrofluoroalkane (HFA) propellant or the like, containing substance, either as a suspension or solution.

(156) In yet another alternative embodiment the substance supply unit 519 could comprise a nebulizer which delivers a metered dose of substance, as an aerosol spray, on actuation thereof.

(157) In this embodiment the substance supply unit 519 is a multi-dose unit for delivering a plurality of metered doses of substance. In another embodiment the substance supply unit 519 could be a single-dose unit for delivering a single metered dose of substance.

(158) In this embodiment the substance supply unit 519 is pre-primeable, here by loading a resilient element, and includes an actuation mechanism 541 which, when triggered, releases the resilient element and actuates the substance supply unit 519 to deliver a metered dose of substance through the anterior nozzles 535a, b and the posterior nozzle 536. In this embodiment the actuation mechanism 541 is breath actuated in response to nasal exhalation by the subject, which nasal exhalation acts to generate a positive pressure in the nasal cavity, which is fluidly connected to the actuation mechanism 541 by the flow channel 527 of the nosepiece unit 517. The generation of a positive pressure in the nasal cavity also advantageously provides for expansion of the nasal cavity, which facilitates deposition on the surfaces within the nasal cavity.

(159) Operation of the delivery device will now be described hereinbelow with reference to FIGS. 34 to 36 of the accompanying drawings.

(160) Referring to FIG. 34, the nosepiece unit 517 is first inserted into one of the nasal cavities of a subject until the first nosepiece member 523 abuts the nares of the nostril, such as sealingly to engage the skin-lined anterior section of the anterior region of the nasal cavity, and the second nosepiece member 525 extends into the nasal valve.

(161) Referring to FIG. 35, the subject then exhales, or at least attempts to exhale through the nasal cavity, which nasal exhalation triggers the actuation mechanism 441, which in turn acts to actuate the substance supply unit 519 to deliver a metered dose of substance, in this embodiment substance for systemic application, from the anterior nozzles 535a, 535b and the posterior nozzle 536.

(162) The substance as delivered from the anterior nozzles 535a, b is delivered to surfaces in the anterior region of the nasal cavity, and the substance as delivered from the posterior nozzle 536 is delivered to an anterior section of the posterior region of the nasal cavity, in this embodiment the anterior third of the posterior region of the nasal cavity, and more preferably substantially to the mid-anterior third of the posterior region of the nasal cavity. As described hereinabove, the present inventors have recognized that the systemic uptake of substance as delivered via the nasal cavity is, contrary to current thinking, enhanced where delivered through the anterior region of the nasal cavity and the anterior third of the posterior region of the nasal cavity, and thus, by confining the delivered dose of substance to the anterior region and the anterior third of the posterior region of the nasal cavity, an enhanced systemic effect is obtained per unit dose of substance as compared to the conventional delivery of substances into the nasal cavity, such as generally by a nasal spray or nasal drops.

(163) Following actuation, as illustrated in FIG. 36, the nosepiece unit 517 is withdrawn from the nasal cavity of the subject.

(164) In one embodiment, where the delivery device is a single-dose device, the device can be discarded.

(165) In another embodiment, where the delivery device is a multi-dose device, the device is ready for further use following priming of the substance supply unit 519. In a preferred embodiment, where the nosepiece unit 417 is replaceable, the nosepiece unit 517 can be replaced with a new nosepiece unit 517.

(166) Finally, it will be understood that the present invention has been described in its preferred embodiments and can be modified in many different ways without departing from the scope of the invention as defined by the appended claims.

(167) For example, in one embodiment the substance could be formulated such as to hinder mucociliary clearance, as would occur from the ciliated mucosal surfaces in the posterior region of the nasal cavity, and also prevent gravitational flow of the substance and dripping out of the substance from the nasal cavity. Typically, the formulation could have adhesive properties, for example, as a thixotropic formulation, and in one embodiment could be formulated in the manner of a gel.

(168) In another embodiment the substance supply units 19, 119, 219, 319, 419, 519 of the above-described embodiments could be configured to deliver a combination of liquid and powdered substances.

REFERENCES

(169) 1. Cole, P. The Respiratory Role of the Upper Airway, Mosby, 1992, pages 7 and 8. 2. Daley-Yates, P T et al, Systemic bioavailability of fluticasone propionate administered as nasal drops and aqueous nasal spray formulations, Br J Clin Pharmacol, January 2001, 51(1), pages 103 to 105. 3. Harris A S et al, Intranasal administration of peptides: nasal deposition, biological response and absorption of desmopressin, J Pharm Sci, November 1985, 75(11), pages 1085 to 1088. 4. Rosenberger, H, Growth and Development of the Naso-Respiratory Area in Childhood, PhD Thesis, Laboratory of Anatomy, School of Medicine, Western Reserve University, Presented to the Annual Meeting of the American Laryngological, Rhinological and Otological Society, Charleston, S.C., USA, 1934. 5. Zacharek, M A et al, Sagittal and Coronal Dimensions of the Ethmoid Roof: A Radioanatomic Study, Am J Rhinol 2005, Vol 19, pages 348 to 352.