DOSE GUIDES FOR INJECTION SYRINGE

Abstract

The present embodiments provide for simple devices that guide the loading and dispensing of accurate small doses of fluid from standard injection syringes.

Claims

1-22. (canceled)

23. A dose-loading guide for loading an injection syringe, the dose-loading guide comprising: a grip portion; and a collar portion connected to the grip portion; wherein the collar portion is rigid along its height, the collar portion defines an opening that removably receives a dose-delivery guide during dose loading of an injection syringe, and the collar portion is configured to stop movement of an extended syringe plunger rod into an injection syringe barrel at a predetermined distance defined between the proximal end of the injection syringe barrel and the distal end of the plunger rod; wherein the dose-delivery guide has a height, the difference between the collar portion height and the dose-delivery guide height corresponds to a volume of fluid to be delivered by the syringe, and, if the syringe barrel comprises a depression in which the dose-delivery guide will sit, the difference corrects for the depression; and wherein the grip portion facilitates positioning of the collar portion around the dose-delivery guide and along the plunger rod during dose loading, and the grip portion facilitates removal of the dose-loading guide after dose loading is complete.

24. The removable dose-loading guide of claim 23, further comprising an indication of a dose volume to be retained by the injection syringe after use of the dose-loading guide.

25. The dose-loading guide of claim 23, wherein the collar portion is integral to the grip portion.

Description

DESCRIPTION OF THE DRAWINGS

[0012] FIG. 1A is a photograph showing the top view of an embodiment of the invention. FIG. 1B shows a side view of an embodiment of the invention.

[0013] FIGS. 2A and 2B are schematic diagrams showing dimensions of an embodiment of the invention. N.T.S. indicates drawings are not to scale.

[0014] FIGS. 3A to 3D illustrate use of an embodiment of the dose-loading spacer with a conventional syringe. In FIG. 3A, the syringe has been loaded with an excess volume of fluid; double arrow indicates the movement of the spacer into position. In FIG. 3B, the syringe guide has been placed at the proximal (top) end of the syringe barrel, abutting the plunger rod; double arrow indicates motion of the plunger. In FIG. 3C, the plunger has been depressed against the dose-loading spacer, which has regulated the expulsion of the excess fluid but caused the syringe to retain an accurate and pre-determined amount of fluid. In FIG. 3D, the guide has been removed, and the syringe contains the accurate dose as determined by the guide. The devices in the drawings of FIG. 3 are not to scale.

[0015] FIG. 4A is a photograph of a syringe bearing an example dose-delivery guide that has been placed on the syringe plunger rod (arrow), and an example removable dose-loading spacer. FIG. 4B is a photograph of the syringe of FIG. 4A with the dose-loading spacer placed adjacent to the dose-delivery guide, illustrating how the guides can be configured to fit together.

[0016] FIGS. 5A and 5B are photographs of example dose-loading and dose-delivery guides with predetermined measurements correlated with the volume to be loaded and delivered. In this embodiment, the dose-delivery guide has a greater length dimension than the dose-loading guide because the syringe flange at the proximal end of the barrel has an indentation that receives the dose-delivery guide to the depth of 0.6 mm. * indicates critical measurement: tolerance should be within * 0.02 mm. ID: inner dimension; OD: outer dimension.

DETAILED DESCRIPTION

[0017] It should be understood that this invention is not limited to the particular methodology, protocols, and reagents, etc., described herein and as such may vary. The terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention, which is defined solely by the claims.

[0018] As used herein and in the claims, the singular forms include the plural reference and vice versa unless the context clearly indicates otherwise. The term or is inclusive unless modified, for example, by either. Other than in the operating examples, or where otherwise indicated, all numbers expressing quantities of ingredients or reaction conditions used herein should be understood as modified in all instances by the term about.

[0019] All patents and other publications identified are expressly incorporated herein by reference for the purpose of describing and disclosing, for example, the methodologies described in such publications that might be used in connection with the present invention. These publications are provided solely for their disclosure prior to the filing date of the present application. Nothing in this regard should be construed as an admission that the inventors are not entitled to antedate such disclosure by virtue of prior invention or for any other reason. All statements as to the date or representation as to the contents of these documents is based on the information available to the applicants and does not constitute any admission as to the correctness of the dates or contents of these documents.

[0020] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as those commonly understood to one of ordinary skill in the art to which this invention pertains. Although any known methods, devices, and materials may be used in the practice or testing of the invention, the methods, devices, and materials in this regard are described herein.

[0021] An embodiment of the present invention provides for a dose-loading spacer guide for loading the correct volume of fluid (e.g., unit dose) in a standard hypodermic syringe. The term dose-loading spacer is synonymous with dose-loading guide, but in some instances herein, spacer is used to further distinguish from the dose-delivery guide described herein. The dose-loading spacer may be made of any suitably rigid material, such as plastic or metal (including recycled materials) that can be sterilized or otherwise cleaned for use. It may be removable or permanent in nature. The dose-loading guide may be reusable and long-lasting, or it may be disposable for single-use.

[0022] The dimensions of the spacer, particularly the height of the interior wall of the collar portion, for example as shown as (104) of FIG. 1, are designed in relation to the volume of the syringe to be used in conjunction with the guide. This relationship can be expressed as:

v=r.sup.2h

where v is the unit volume L (or cubic mm) to be delivered by the syringe; r is the mm radius of the interior of the syringe cylinder; and h is the mm length that the plunger has to travel to deliver the unit volume. For example, in a Becton Dickenson 28 gauge insulin syringe (product no. 309300), r=1.475 mm (one-half of the diameter of 2.95 mm). In this syringe, every 1 mm in length corresponds to 6.83 L volume. If the unit volume to be delivered is 7.5 L, (i.e., v=7.5); a spacer having a collar height of 1.1 mm (i.e. h=1.1 mm) can be used to measure a 7.5 L dose (i.e., 7.514=(3.14)(1.475).sup.2(1.1). Thus, one skilled in the art can use the volume dose and diameter of a given syringe to design the corresponding collar dimension. In a particular embodiment, a guide having a 1.1 mm collar is used to accurately load a 7.5 L dose.

[0023] The handle portion of the spacer may be of any practical design (e.g., shape or texture) that allows the user to grip the guide for placement on (and, optionally, removal from) the syringe, e.g., on the top of the syringe barrel abutting the plunger rod. The handle portion may be manufactured contiguous to the collar, or may be connected (either detachably or fixed) to the collar portion by any other approach. The dose-loading guide may also bear a label or instruction(s).

[0024] As noted, the dose-loading guide of the present invention may be used with commercially available syringes. Because the spacer is useful for accurately loading small volumes, typically the syringe used will be for small-dose administration, such as a tuberculin syringe (Becton Dickinson, Franklin Lakes, N.J.) or an insulin syringe (Becton Dickinson), for example, BD 3/10 cc Insulin Syringe, or BD 0.5 cc Hypak glass syringe. The present dose-loading guide can also be used in other applications where accurate and repeatable volumes are required, for example syringes used to load chromatography samples such as HPLC or autosampler syringes (e.g., Hamilton Syringes, Sigma Aldrich, St. Louis, Mo.).

[0025] In use, the hypodermic syringe is loaded with fluid (e.g., medicine, drug, formulation, therapeutic agent, placebo, or sample) in excess of the amount needed for the actual dose. Air bubbles may be tapped out of the syringe and needle. The dose-loading guide is then placed on the proximal (top) end of the syringe barrel, abutting the plunger rod (typically where the plunger enters the syringe barrel), and the plunger depressed until the collar portion of the spacer stops the motion of the plunger. In this process, excess fluid is expelled from the syringe, leaving an accurate dose loaded in the barrel of the syringe as determined by the size of the collar portion of the dose-loading spacer. The guide may then removed, such that the plunger may be depressed fully as the dose is delivered. For example, a dose-loading guide can be used to accurately load 7.5 L using a standard, commercially available tuberculin syringe.

[0026] Referring to the Drawings, FIG. 1 shows an embodiment of the syringe dose-loading guide/spacer (100). The spacer has a grip portion (101) that serves as a handle or other means whereby the user can position the guide. The guide has a collar portion (102) that defines an opening (103) that is, in use, placed by the user such that it abuts the top end of a standard syringe. In use, the movement of the plunger rod into the barrel of the syringe is impeded by the height of the spacer (104). FIG. 2 presents measurements of particular parts of a dose-loading spacer embodiment.

[0027] Referring to FIG. 3, a standard, commercially available syringe (305) is loaded with formulation for injection (306), in an amount in excess of the desired dose. The guide (300) may be held by the grip portion (301) such that the collar portion (302) opening (303) abuts the proximal end of the syringe barrel (308), e.g., at the distal end of the extended syringe plunger rod (307). As indicated by the double arrow in FIG. 3B, the plunger (307) is then depressed into the barrel of the syringe (305) until the proximal end of the plunger (309) contacts the guide (300), as shown in FIG. 3C. Thus, the dose remaining in the syringe (306) is regulated directly by the dimension of the guide (304). Then, the guide may be removed, as shown in FIG. 3D, and the syringe is ready for the delivery (e.g., administration) of the accurately loaded dose.

[0028] Another aspect of the invention provides for a dose-delivery guide that can used without or in conjunction with a dose-loading guide to accurately deliver small volumes of fluid (e.g., medicament, pharmaceutical composition, sample, etc.) to a target (e.g., a subject or device). The dose-delivery guide has predetermined dimensions, designed to fit at the top (proximal) end of a standard syringe or integral to the plunger rod. The guide is optimally designed to remain stably in place on the syringe during use and does not have to be held in place by the user as the syringe is being used to deliver the dose. For example, the guide may be shaped to fit along and substantially around a syringe plunger rod and allow the plunger rod to move through the guide, or the guide may be integral to the plunger rod. This configuration allows the user to inject the syringe with one hand holding the syringe and the other hand free for any particular use. The circumference of the dose-delivery guide may be deformable or rigid, continuous or non-continuous, such that it may be placed abutting the syringe plunger either before or after the plunger is engaged with its syringe, respectively. The guide may be removable or permanent. The guide may be configured to be placed on the syringe either before or after the syringe is loaded. The dose-delivery guide must maintain rigidity along its height (i.e., the dimension related to the dose volume). The dose-delivery guide may be made of any suitable material. e.g., metal or sterilizable plastic, which maintains dimension along the length of the guide.

[0029] The use of the dual dose-loading and dose-delivery system is advantageous where syringe devices have deformable plunger/syringe interfaces, such as rubber ends, where the pressure exerted by the user can lead to a larger volume being delivered than is intended. Because the distance the plunger travels within the syringe barrel is fixed by the height of the dose-loading spacer and the height of the dose-delivery guide (rather than the depression of the plunger against the syringe), a more precise and accurate volume of medication can be administered. The difference in the dimensions of the height of the dose-loading spacer and the height of the dose-delivery guide are calculated from the formula:

V=r.sup.2h

where V is the volume delivered, r is the radius of the inner dimension of the syringe barrel and h is the distance the piston has to travel along the length of the syringe barrel. For example, if the dose volume to be delivered is 7.5 L, then:

V=7.5 L or 7.5 mm.sup.3

r=2.3 mm (diameter was measured to be 4.6 mm)

V=r.sup.2h, or h=V/r.sup.2

h=7.5 mm.sup.3/(3.14)(2.3 mm)(2.3 mm)=0.45 mm

Thus, the difference in the dimensions of the height of the dose-loading spacer guide and the height of the dose-delivery ring guide for a syringe with inner dimension 4.6 mm and for the loading and delivery of a dose of 7.5 L was calculated to be 0.45 mm.

[0030] As can be seen from FIG. 4, the dose-delivery guide can be shaped as a ring or cylinder, or it can have any shape of predetermined dimension. In use, the guide is placed on the syringe, typically at the top or proximal end. In the specific example shown in FIG. 4, the guide can be placed around the plunger rod of the syringe (FIG. 4A). In FIG. 4, the dose-delivery guide's inner dimension (I.D.) is slightly larger than the outer dimension (O.D.) of the plunger, such that the guide can move freely along the length of the plunger. In other words, in FIG. 4, the plunger moves through the dose-delivery guide. In the specific embodiment shown in FIG. 4, the dose-delivery guide is a continuous metal ring, and can be placed on the plunger before the plunger is engaged with the syringe, or before or after the syringe is loaded. Alternatively, the dose-delivery guide may have an opening on the circumference to allow it to deform and snap on an extended plunger, substantially surrounding the plunger so that it may be released by the user and maintain its position along the plunger. The dose-delivery guide can be removeable or permanent.

[0031] The guide can be used without or with the dose-loading spacer described herein. In a particular embodiment, the dose-delivery guide is configured to fit snuggly into the opening of the dose-loading spacer guide (FIG. 4B). Alternatively, the dose-loading spacer is configured to abut either end of the dose-delivery guide.

[0032] In use, the dose-delivery guide is placed on the syringe either before or after the syringe is loaded with fluid. The amount of fluid loaded may be determined in traditional fashion (e.g., by visual inspection), without use of a dose-loading spacer. In this circumstance, the dose-delivery guide is advantageous when the syringe is somewhat deformable, such that the dose delivery guide adds stability and thus better control over the dose delivered.

[0033] When used with the dose-loading spacer, the dose-delivery guide is placed on the syringe either before or after the syringe is loaded with fluid; the syringe is loaded with excess fluid; the dose-loading guide spacer is placed over/against the dose-delivery guide; the plunger is depressed until the dose-loading spacer stops the motion of the plunger, expelling excess fluid; the dose-loading guide is removed; the syringe needle is placed where the fluid is to be delivered; the plunger is depressed until the dose-delivery guide stops the motion of the plunger, delivering the fluid (e.g., administering the medication). In other words, the plunger travels along the length of the syringe barrel from point A to point B, the distance between point A and B is directly related to the height of the dose-loading spacer and the height of the dose-delivery guide, and related to the volume (dose) to be delivered by the syringe.

[0034] Referring to FIG. 5, this embodiment illustrates a system of a dual dose-loading spacer (FIG. 5A) configured for use with a dose-delivery guide (FIG. 5B). This example was designed for use with a BD 0.5 cc Hypak glass syringe with a BD PrecisionGlide 27 G needle to deliver a dose of 7.5 L. In this example, the syringe has a depression at the proximal end in which the dose-delivery guide inserts 0.6 mm. Thus, the dimensions of the dose-delivery guide has a longer height than that of the dose-loading guide, 8.01 mm compared to 7.86 mm spacer, respectively, to account for the depression in the syringe and still guide the accurate delivery of a 7.5 L dose.

[0035] The dose-loading guide, dose-delivery guide, and the dual guide system (dose-loading/dose-delivery guides) of the present invention are particularly useful in circumstances where precise volumes of medication or sample are required. For example, delivery of a precise volume can be important when a pharmaceutical is very active such that a small amount results in significant biological activity (such as insulin); or where a pharmaceutical may have side-effects if a non-precise volume is delivered; or where the site of administration is small, such as in the eye (for example, IBI-20089, IBI-10090, LUCENTIS ranibizumab injection, AVASTIN bevacizumab, or VEGF Trap-Eye).

[0036] The dose-loading guide, dose-delivery guide or dual guide system of the present invention may also be included in a kit. The kit may include at least one guide or dual guide system; or may include a first guide or dual guide system for loading a first dose unit, and a second guide or second dual guide system for loading a second dose unit volume, etc. The kit may include at least one syringe for use with the guide or dual guide system. The kit may include a pharmaceutical or other active agent, a standard (e.g., for use with analytical detection), or materials for user practice (e.g., saline). The pharmaceutical may be preloaded into the syringe, e.g., excess pharmaceutical has been preloaded into the barrel of the syringe.

EXAMPLES

Example 1. Improvement of Small Volume Syringe-Loading Accuracy with Dose-Loading Spacer

[0037] This example was designed to determine the standard deviation of using a 28 gauge syringe to deliver 7.5 L of a sustained release composition (IBI-10090, having a density of 1.15 mg/L), with or without a dose-loading spacer guide.

[0038] Four people were given ten commercial insulin syringes (28 gauge); for each syringe, about 10 L was drawn directly from a sample vial. Excess sample was expressed until approximately 7.5 L was retained in the syringe as determined visually (i.e., by eyeballing the correct unit volume). The unit volume was then injected into a tared vial and the weight recorded. This was repeated for all ten syringes.

[0039] The same four people then withdrew about 10 L of sample and expressed the excess volume with the aid of the removable dose-loading guide as described herein until approximately 7.5 L was retained in the syringe as determined by the collar portion of the dose-loading guide. The unit volume was then injected into a tared vial and the weight recorded. This was repeated for all ten syringes. The data are shown in Table 1:

TABLE-US-00001 TABLE 1 Comparative accuracy of syringe loading, dosing, without or with guide without dose-loading guide with removable dose-loading guide User 1 2 3 4 1 2 3 4 Syringe (mg) (mg) (mg) (mg) (mg) (mg) (mg) (mg) 1 7.23 10.85 9.47 7.76 9.52 9.50 9.55 8.15 2 7.54 10.11 7.06 9.56 9.62 9.94 9.01 8.18 3 7.47 9.50 9.36 10.09 8.93 9.37 8.25 9.08 4 8.47 9.96 13.36 6.12 9.60 8.44 7.70 8.30 5 7.10 10.11 12.43 9.85 8.70 8.55 8.48 8.89 6 9.23 11.20 7.94 10.47 8.48 7.63 9.07 8.15 7 9.54 8.51 10.42 8.99 9.20 8.10 8.06 7.89 8 8.32 8.45 10.28 10.06 9.75 8.12 8.74 8.06 9 9.19 11.94 10.72 8.99 8.43 8.15 9.62 8.39 10 9.09 10.06 11.53 7.30 8.79 9.23 7.75 8.11 Average weight (mg) 9.39 Average weight (mg) 8.68 SD 1.57 SD 0.63 RSD 16.68 RSD 7.28 Average volume (L) 8.17 Average volume (L) 7.48 SD 1.36 SD 0.55 RSD 16.68 RSD 7.35

[0040] As can be seen from the data in Table 1, significant accuracy was achieved by using the dose-loading spacer device.

[0041] In several additional experiments using the removable dose-loading guide, syringes were loaded with a pharmaceutical composition using the guide, and accuracy was demonstrated as shown in Table 2:

TABLE-US-00002 TABLE 2 Accuracy of 300 guided 7.5 L doses # syringes # users Total ave mg ave L 10 10 100 8.72 1.05 7.58 0.91 10 10 100 8.454 0.79 7.43 0.69 10 10 100 8.55 0.68 7.50 0.59

[0042] A further set of data was collected using water, as shown in Table 3:

TABLE-US-00003 TABLE 3 Accuracy of 100 guided 7.5 L doses # syringes # users Total ave mg ave L 10 10 100 7.53 0.44 7.53 0.44

Example 2. Dual Dose-Loading/Dose-Delivery Guide System

[0043] In early experiments, using a 8.45 mm dose-loading spacer and a 8.00 mm dose-delivery ring with the BD 0.5 cc Hypak glass syringe attached with a BD PrecisionGlide 27 G needle, the volume delivered was higher than the expected 7.5 L. After careful examination of the BD Hypak syringe, it was found that the flange of the proximal end of the syringe, where the plunger rod enters the syringe barrel, is not perfectly flat; but rather it has a 0.6 mm depression or groove in which the delivery-guide actually seats into or sinks in. The dimensions of the dose-loading guide and the dose-delivery guide were then re-designed to make a 7.85 mm spacer and corresponding 8.0 mm ring, which resulted in the more accurate delivery of a 7.5 L dose. Table 4 shows data compiled using this dual guide system for a fluid having a density of 1.16 gm/mL (1.16 mg/L), such that 8.62 mg/1.16 mg/L=7.43 L.

TABLE-US-00004 TABLE 4 Delivery of 7.5 L using dual dose-loading dose-delivery guide system Syringe # 1 2 3 4 5 6 7 Weight (mg) Volume (L) 9.10 8.89 8.65 8.27 8.27 9.37 8.71 9.18 8.69 9.16 8.20 8.90 9.69 7.29 8.55 8.22 9.17 7.98 8.57 9.99 7.91 8.38 8.54 8.94 8.70 8.79 8.92 8.37 9.96 9.03 8.99 8.34 8.58 9.33 8.06 8.44 8.35 8.62 8.32 8.67 9.20 6.89 8.88 8.71 9.02 8.56 8.32 8.56 7.28 8.85 8.41 9.11 8.65 8.89 8.41 7.98 8.97 8.08 8.44 8.20 8.79 7.93 7.87 9.12 8.80 8.88 8.18 8.47 9.42 8.50 Average 8.94 8.57 8.90 8.34 8.63 9.08 7.89 8.62 7.43 SD 0.46 0.31 0.25 0.23 0.22 0.63 0.58 0.55 0.47 RD 5.12 3.56 2.81 2.75 2.59 6.91 7.38 6.39 6.39