Medical preparation container comprising microwave powered sensor assembly
10856372 ยท 2020-12-01
Assignee
Inventors
Cpc classification
H05B6/686
ELECTRICITY
H05B6/664
ELECTRICITY
International classification
B01J19/12
PERFORMING OPERATIONS; TRANSPORTING
Abstract
The present invention relates to a medical preparation container which includes a microwave power sensor assembly. The microwave powered sensor assembly includes a sensor configured to measure a physical property or chemical property of a medical preparation during its heating in a microwave oven. The microwave powered sensor assembly is configured for harvesting energy from a microwave radiation emitted by the microwave oven and energize the sensor by the harvested microwave energy.
Claims
1. A medical preparation container comprising: material to hold a medical preparation for heating in a microwave oven; and a microwave powered sensor assembly comprising: a microwave antenna configured to receive microwave radiation within the microwave oven during heating of the medical preparation, the microwave antenna having a predetermined tuning frequency to generate a radio frequency (RF) antenna signal in response to the microwave radiation at a predetermined excitation frequency, wherein the microwave antenna is powered by the microwave radiation without an external power source outside the microwave oven; a direct current (dc) power supply circuit coupled to the microwave antenna and configured to receive the RF antenna signal and produce a power supply voltage by rectifying and extracting energy from the RF antenna signal; and a sensor connected to the power supply voltage and configured to measure and output a physical property or a chemical property of the medical preparation held in the medical preparation container during heating of the medical preparation, wherein the microwave powered sensor assembly is attached to a wall of the material to hold the medical preparation or partially or fully embedded into the wall of the material to hold the medical preparation, wherein the medical preparation container is to operate enclosed within a microwave oven without an external power source outside the microwave oven.
2. The medical preparation container of claim 1, wherein the microwave powered sensor assembly further comprises: an RF power limiter coupled between the microwave antenna and the dc power supply circuit to limit an amplitude or power of the RF antenna signal in accordance with predetermined signal limiting characteristics.
3. The medical preparation container of claim 2, wherein the RF power limiter of the microwave powered sensor assembly comprises: a variable impedance circuit coupled to the microwave antenna, wherein the variable impedance circuit exhibits an input impedance that decreases with increasing amplitude or power of the RF antenna signal at the predetermined excitation frequency to decrease a matching between the input impedance of the RF power limiter and an impedance of the microwave antenna.
4. The medical preparation container of claim 1, wherein the predetermined tuning frequency of the microwave antenna deviates from the predetermined excitation frequency of the microwave radiation by more than +50% or more than 33%.
5. The medical preparation container of claim 4, wherein the predetermined tuning frequency of the microwave antenna is at least 50% higher than the predetermined excitation frequency of the microwave radiation.
6. The medical preparation container of claim 1, wherein the microwave antenna comprises at least one of: a monopole antenna, a dipole antenna, or a patch antenna.
7. The medical preparation container of claim 1, comprising at least one of: a medical fluid bag, an agar container, or a syringe.
8. The medical preparation container of claim 1, wherein the sensor of the microwave powered sensor assembly is arranged to obtain physical contact or sensory contact with the medical preparation.
9. The medical preparation container of claim 1, wherein the microwave powered sensor assembly is partially or fully embedded in a wall section, a lid section, or a bottom section of the wall of the material of the medical preparation container.
10. The medical preparation container of claim 1, wherein the microwave powered sensor assembly is detachably fastened to a wall section, a lid section, or a bottom section of the wall of the material of the medical preparation container.
11. The medical preparation container of claim 1, wherein the microwave powered sensor assembly comprises: an electrically conductive housing configured to enclose and shield at least the dc power supply circuit against the microwave radiation.
12. The medical preparation container of claim 1, wherein the microwave powered sensor assembly further comprises: a digital processor coupled to the power supply voltage for receipt of operating power; and a wireless data transmitter to transmit, to an exterior of an oven chamber of the microwave oven, parameter values of the physical property or the chemical property of the medical preparation during heating of the medical preparation.
13. The medical preparation container of claim 12, wherein the microwave powered sensor assembly further comprises: a data memory to store a target temperature profile for heating of the medical preparation, the digital processor being configured to read the target temperature profile from the data memory and transmit the target temperature profile via the wireless data transmitter to the exterior of the oven chamber during heating of the medical preparation.
14. A method of monitoring a physical property or a chemical property of a medical preparation during heating, the method comprising: a) positioning a medical preparation container, holding a medical preparation inside an oven chamber of a microwave oven, wherein the medical preparation container comprises material to hold the medical preparation for heating in the microwave oven and a microwave powered sensor assembly comprising a sensor, wherein the microwave powered sensor assembly is attached to a wall of the material or partially or fully embedded into the wall of the material; b) activating the microwave oven to produce electromagnetic radiation within the oven chamber thereby irradiating and heating the medical preparation; c) extracting energy from a radio frequency (RF) antenna signal in response to irradiation of the microwave powered sensor assembly by the electromagnetic radiation such that the microwave powered sensor assembly is powered by the electromagnetic radiation without an external power source outside the oven chamber of the microwave oven; and d) repeatedly measuring a physical property or a chemical property of the medical preparation by the sensor that is powered by the energy extracted from the RF antenna signal.
15. The method of claim 14, further comprising at least one of: displaying a parameter value of the physical property or the chemical property of the medical preparation; or transmitting a parameter value of the physical property or the chemical property of the medical preparation to a wireless receiver arranged outside the oven chamber via a wireless data communication link.
16. The medical preparation container of claim 1, wherein the microwave powered sensor assembly comprises a display to display a parameter value the physical property or the chemical property of the medical preparation during heating of the medical preparation.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) Preferred embodiments of the invention will be described in more detail in connection with the appended drawings, in which:
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DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
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(12) The microwave powered sensor assembly 105 comprises a microwave antenna 102 with a tuning frequency in the microwave region or frequency rangefor example a tuning frequency between 800 MHz and 3.0 GHz. The microwave antenna 102 is responsive to excitation by the microwave radiation or electromagnetic field generated in an oven chamber of the industrial or consumer type of microwave oven in question during heating of the medical preparation held in the medical preparation container 100. The medical preparation container 100 may be positioned or inserted into the oven chamber by a medical professional and the microwave oven activated thereafter. The skilled person will understand that the microwave antenna 102 may be dimensioned or designed with a tuning frequency of about 2.45 GHz if the medical preparation container 100 is intended for use in consumer type of microwave ovens. The microwave antenna 102 may be dimensioned or designed with a tuning frequency of about 915 MHz if the medical preparation container 100 is intended for use in industrial type of microwave ovens. The tuning frequency of the microwave antenna 102 may alternatively be detuned with a predetermined amount from the expected excitation frequency, either 2.45 GHz or 915 MHz, of the microwave radiation as discussed above.
(13) A sensory portion of a sensor 108 of the microwave powered sensor assembly 105 may be in physical contact with the medical preparation to measure or detect a physical property of the medical preparation during heating such as a temperature, viscosity, pressure, colour, humidity, electric conductivity etc. In the alternative, the sensor 108 may operate without physical contact to the medical preparation and instead measure the physical property of the medical preparation by remote or non-contact sensing, e.g. using an infrared (IR) temperature detector etc. The sensory portion of the sensor 108 may alternatively measure or detect a chemical property of the medical preparation under heating for example its water content, its pH level or the presence and/or concentration of certain chemical agents such as salt, sugar, acids, fats etc. in the medical preparation.
(14) The skilled person will understand that the sensor 108 may be configured to measure or detect several different physical properties of the medical preparation and/or one or more chemical properties. The microwave powered sensor assembly 105 may comprise multiple individual sensors of different types to measure the different physical properties and/or chemical properties of the medical preparation.
(15) The microwave antenna 102 is responsive to the excitation by the microwave radiation as mentioned above to generate a RF (radio frequency) antenna signal which is connected to an input of a dc (DC) power supply circuit 106 of the microwave powered sensor assembly 100 either directly or through an optional RF power limiter 104 as discussed below. The DC power supply circuit 106 is configured to rectify the received RF antenna signal and extract a DC power supply voltage V.sub.DD therefrom. The DC power supply circuit 106 may comprise one or more filter or smoothing capacitor(s) coupled to the output of a rectifying element. Several types of rectifying elements may be used such as semiconductor diodes or actively controlled semiconductor switches/transistors. In one embodiment, the rectifying element comprises a Schottky diode as schematically indicated on circuit block 106. The one or more filter or smoothing capacitor(s) serves to suppress voltage ripple and noise on the DC supply voltage V.sub.DD and may further serve as an energy reservoir. The energy reservoir stores extracted energy for a certain time period and ensures that the DC power supply voltage remains charged or powered during short drop outs of the RF antenna signal as discussed below in additional detail. The sensor 108 is powered or energized by the DC supply voltage V.sub.DD for example via a power supply terminal or input of the sensor 108 connected to V.sub.DD. The sensor 108 may comprise various types of active digital and/or analog electronic circuitry and/or display components that need power to function properly.
(16) The microwave powered sensor assembly 105 preferably comprises a housing or casing 110 surrounding and enclosing at least the DC power supply circuit 106 and sensor 108. The housing 110 may be hermetically sealed to protect these circuits and the sensor(s) enclosed therein against harmful liquids, gasses or other contaminants inside the oven chamber. The previously discussed sensory portion of the sensor 108 may protrude to the outside of the housing 110 and through the wall of the medical preparation container 100. This will allow the sensory portion to obtain physical contact with the medical preparation. The housing 110 may comprise an electrically conductive layer or shield, such as a metal sheet or metal net enclosing at least the power supply circuit 106 and the sensor 108, against the strong RF microwave electromagnetic field generated by the microwave oven during operation. The microwave or RF antenna 102 is preferably placed outside the electrically shielded housing 110 to allow unhindered harvesting of the microwave energy from the microwave radiation or field.
(17) The measured or detected physical property and/or chemical property of the medical preparation may be indicated to a user of the microwave oven in numerous ways. In certain embodiments of the microwave powered sensor assembly 105, the latter comprises a display configured to displaying parameter values or respective parameter values of the measured physical and/or chemical properties of the medical preparation to the outside of the microwave oven as discussed in further detail below with reference to
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(19) Hence, the RF antenna signal is electrically coupled or connected to an input of the RF power limiter 104 instead of directly to the DC power supply circuit 106 as in the first embodiment of the microwave powered sensor assembly. The RF power limiter 104 is configured to limiting a level such as amplitude level, power level or energy level of the RF antenna signal in accordance with signal limiting characteristics of the RF power limiter 104. The RF power limiter 104 produces a limited RF antenna signal V.sub.LIM at a limiter output in response to the RF antenna signal. The signal limiting characteristics may for example comprise a linear behaviour at relatively small levels of the RF antenna signal, for example below a certain threshold level, and a non-linear behaviour above the threshold level. In this manner, the level of the RF antenna signal and the level of the limited RF antenna signal may be largely identical for RF antenna signals below the threshold level while the level of the limited RF antenna signal may be smaller than the level of the RF antenna signal above the threshold level. Various circuit details and mechanisms to produce different types of signal limiting characteristics of the optional RF power limiter 104 are discussed below in additional detail.
(20) The inclusion of the RF power limiter 104 has several advantages for example by protecting the down-stream DC power supply circuit 106, electrically coupled to the limited RF antenna signal, against overvoltage conditions created by excessively large power levels or amplitude levels of the RF antenna signal in response to the RF electromagnetic radiation in the oven chamber. These excessive signal input conditions are quite contrary to the operation of normal wireless RF data communication equipment where the challenge often is to obtain sufficient RF power to safely transmit or decode data signals modulated onto the carrier wave. In contrast, the microwave powered sensor assembly 155 will often be placed very close to the source of the RF electromagnetic radiation in the oven chamber leading to excessively large voltages and input power of the RF antenna signal. Furthermore, the strength of the microwave radiation in the oven chamber is often highly variable through the chamber due to standing waves. These standing waves lead to the formation of so-called hot spots and cold spots inside the oven chamber during operation with highly different field strengths of the microwave radiation. The microwave powered sensor assembly 155 should be configured to at one hand extract sufficient power from the microwave antenna to ensure proper operation when positioned in a cold spot and on the other hand be able to withstand very large amplitude RF antenna signals when the microwave antenna is positioned in a hot spot. In the latter situation, the RF power limiter 104 ensures that these large amplitude RF antenna signals are attenuated by reflecting a large portion of the incoming RF signal power back to the microwave antenna for emission as discussed in further detail below.
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(22) Hence, these latter circuits are connected to the DC power supply voltage V.sub.DD for receipt of operating power. The sensor 208 may comprise various types of active digital and/or analog electronic circuitry and/or display components that need power to function properly. The digital processor 214 may comprise a hard-wired digital processor configured to perform various predetermined control functions of the microwave powered sensor assembly 200. In the alternative, the digital processor 214 may comprise a software programmable microprocessor adapted to perform the control functions of the microwave powered sensor assembly 200 in accordance with a set of executable program instructions stored in program memory of the software programmable microprocessor. The digital processor 214 may comprise an input port connected to the sensor 208 for receipt of measured parameter values of the previously discussed physical or chemical properties in question of the medical preparation. A sensory portion of the sensor 208 may be in physical or sensory contact with the medical preparation to measure or detect the physical property of the medical preparation during heating/preparation such as a temperature, viscosity, pressure, colour, humidity, electric conductivity etc. The skilled person will understand that the measured parameter values may be outputted by the sensor 208 in analog format or in digital format depending on the characteristics of the sensor 208 and any signal conditioning circuitry integrated with the sensor. If the parameter values are outputted in digital format, the input port of the digital processor 214 may comprise an ordinary I/O port or an industry standard data communication port such as I2C or SPI. If the parameter values are outputted by the sensor 208 in analog format, the input port of the digital processor 214 may comprise an analog input connected to an internal A/D converter to convert the received parameter values to a digital format and create a corresponding data stream or data signal comprising the measured parameter values. The optical data transmitter 218 is coupled to a data port of the digital processor 214 supplying the measured parameter values encoded in a predetermined data format to the optical data transmitter 218 for optical modulation and transmission to a suitable optical receiver (not shown) arranged at the outside of the oven chamber. The optical data transmitter 218 may comprise a modulated LED diode emitting the optical data signal by waves in the visible spectrum or in the infrared spectrum. The optical receiver may comprise a photodetector such as a LED. The digital processor 214 and optical data transmitter 218 may be configured to transmit the optical data signal continuously, at regular time intervals or at irregular time intervals during heating of the medical preparation depending on the particular application. The microwave powered sensor assembly 200 preferably comprises a housing or casing 210 surrounding and enclosing at least the RF power limiter 204, dc power supply circuit 206, digital processor 214, sensor 208 and optical data transmitter 218. The housing 210 may possess the same properties as the housing 110 discussed above.
(23) The microwave oven may comprise a glass lid with an inner surface covered by a metallic net or grid which functions as an EMI shield of the oven to prevent leakage of the microwave radiation emitted by the oven during operation to the external environment outside the oven chamber. The photodetector may be attached directly on an outer surface of the glass lid of the microwave oven such that the optical data signal is transmitted through the glass lid to the photodetector. The photodetector may be placed in an opening of the EMI shield allowing the optical waves carrying the optical data signal unhindered propagation to the photodetector. The photodetector may be electrically or wirelessly coupled to a microprocessor of the microwave oven and transmit the received optical data signal, comprising the measured parameter values, to the controller of the microwave oven. The microprocessor of the microwave oven may be configured to use the received parameter values to automatically control the operation of the microwave oven. In one embodiment, the measured parameter values of the medical preparation may comprise current temperatures of the medical preparation and the microprocessor of the microwave oven may be configured to terminate the heating when the current temperature of the medical preparation reaches a certain target temperature.
(24) Another embodiment of the microwave powered sensor assembly 200 additionally comprises a data memory, for example a non-volatile memory such as flash memory, for storage of a target temperature profile for heating of the medical preparation. The digital processor 214 is configured to read the target temperature profile from the data memory and transmit the target temperature profile via the optical data transmitter 218, or another suitable wireless data transmitter, to the exterior of the oven chamber. The target temperature profile may for example be transmitted to the previously discussed photodetector attached to the outer surface of the glass lid of the microwave oven and therefrom to the microprocessor of the microwave oven.
(25) The temperature profile may specify a sequence of target temperatures over time for the heating of the medical preparation. In certain embodiments, the target temperature profile may be formed by a single temperature value for example a stop or termination temperature of the medical preparation. Hence, the control program of the microwave oven may initially receive and record this stop or termination temperature and thereafter monitoring incoming temperature values as repeatedly transmitted by the microwave powered sensor assembly 205 during heating of the medical preparation. In response to the measured temperature of the medical preparation reaches the stored termination temperature, the control program may terminate the heating of the microwave oven, or possibly markedly reducing the amount of emitted microwave energy in the oven chamber to avoid overheating the medical preparation. Hence, the microwave powered sensor assembly and the microwave oven jointly form an intelligent cooperating microwave heating system.
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(30) The intravenous infusion fluid bag 500 may comprise an eye or hole to affix the bag to a mating structure of a pole. The intravenous infusion fluid bag 500 furthermore comprises a liquid flow channel (not shown) for delivery of the liquid medical preparation to an IV line or tubing. The intravenous infusion fluid bag 500 (IV bag) may be manufactured in plastics, silicone, rubber or similar elastomeric materials.
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(32) The sensor 108, 158, 208, 308 of the microwave powered sensor assembly may be brought into physical contact with the outer surface of the predesignated area 502 of the wall of the containerfor example to reduce the thermal resistance between the medical preparation and the sensor.
(33) The microwave powered sensor assembly 105, 155, 205, 305 may comprise a relatively short monopole microwave antenna (not shown). The tuning frequency of the monopole microwave antenna may be somewhat higher than the expected 2.45 GHz radiation frequency of the microwave radiation emitted by the microwave oven. Hence, the monopole microwave antenna 502 is deliberately detuned which offers several advantages. A higher tuning frequency of the monopole microwave antenna relative to at tuning at the 2.45 GHz microwave radiation frequency leads to smaller physical dimensions. The smaller physical dimensions leads to smaller dimensions of the microwave powered sensor assembly and simper integration into the various kinds of equipment such as the present intravenous infusion fluid bag 500. The detuning also decreases the amount of microwave energy picked-up by the monopole microwave antenna and therefore decreases the level of the RF antenna signal level applied to either the RF power limiter (if present) and to the DC power supply circuit. The tuning frequency of the monopole microwave antenna relative to at tuning at the 2.45 GHz microwave radiation frequency may be at least 50% higher leading to a turning frequency of the monopole microwave antenna 502 at or above 3.675 GHz. The microwave powered sensor assembly may further comprise a wireless data transmitter (not shown) for example an optical data transmitter as discussed above. The wireless data transmitter is configured to emit a wireless electromagnetic data signal comprising repeatedly measured temperature values of the liquid medical preparation held in the bag 500 as produced by the temperature sensor 526 during heating of the liquid medical preparation to in the microwave oven. If an optical data transmitter is used, the generated optical data signal may be infrared and possess a sufficiently large level or power to penetrate the oven door to reach an optical receiver placed outside the oven chamber as discussed above. The skilled person will understand that the optical data transmitter may be replaced by, or supplemented by, a display such as the display 312 discussed above. The display may indicate the measured temperature values of the liquid medical preparation or simply indicate that a certain preprogramed target temperature of the the the liquid medical preparation is reached to the exterior of the oven chamber. The user may monitor the current temperature of the the liquid medical preparation by reading temperature indications on the display during heating and manually interrupt the microwave oven when the target or desired temperature is reached. In the alternative, the previously discussed microprocessor of the microwave oven may be configured to automatically interrupt the heating of the microwave oven when the desired temperature is reached. This requires that the optical data signal transmitted by the microwave powered sensor assembly is coupled to the microprocessor of the microwave oven via the photodetector. The photodetector may be mounted on the exterior of the oven door or alternatively positioned within the microwave oven for example viewing into the oven chamber through an aperture or shielding mesh.
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