Isothiazolo-based bicycles, processes for their preparation and their use as herbicides and/or plant growth regulators

Abstract

The invention relates to the technical field of the herbicides and/or plant growth regulators. Specifically, the invention primarily relates to novel substituted isothiazolopyridones, and compositions comprising said novel substituted isothiazolopyridones. Further, the present invention relates to processes for the preparation said novel substituted isothiazolopyridones and their use as herbicides and/or plant growth regulators.

Claims

1. A Compound of the formulae (G1) and (G2) and/or salt thereof ##STR00032## in which A is CR.sup.6R.sup.7, x is 0, 1 or 2, R.sup.1 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkoxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkoxy, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, aryloxy, heteroaryloxy, heterocyclyloxy, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-haloalkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, R.sup.13R.sup.14N-carbonyl, and wherein heterocyclyl has q oxo groups, and wherein each of the aforementioned heterocyclic residues, in addition to the carbon atoms, has in each case p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, R.sup.2, R.sup.3 are each independently hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxyphenyl, (C.sub.1-C.sub.8)-alkoxyphenyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.2-C.sub.8)-alkenyloxycarbonyl, (C.sub.2-C.sub.8)-alkynyloxycarbonyl, (C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.2-C.sub.8)-alkenylcarbonyl, (C.sub.2-C.sub.8)-alkynylcarbonyl, R.sup.13R.sup.14N-carbonyl, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylthiocarbonyl, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphinyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkylsulphinyl-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkylsulphonyl-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenylcarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkylcarbonyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, arylcarbonyl, aryl-(C.sub.1-C.sub.8)-alkylcarbonyl, heteroarylcarbonyl, heteroaryl-(C.sub.1-C.sub.8)-alkylcarbonyl, heterocyclylcarbonyl, or heterocyclyl-(C.sub.1-C.sub.8)-alkylcarbonyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-haloalkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl, hydroxycarbonyl-(C.sub.1-C.sub.4)-alkyl, R.sup.13R.sup.14N-carbonyl, and wherein heterocyclyl has q oxo groups, and wherein each of the aforementioned heterocyclic residues, in addition to the carbon atoms, has in each case p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, or NR.sup.2R.sup.3 is NCR.sup.8R.sup.9 or NS(O).sub.nR.sup.10R.sup.11, R.sup.4, R.sup.5 are each independently hydrogen, formyl, cyano, halogen, oxytetrahydropyranmethyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarbonyloxy, (C.sub.1-C.sub.6)-alkylcarbonyloxy-(C.sub.1-C.sub.6-alkyl, (C.sub.1-C.sub.8)-alkylsilyl, (C.sub.2-C.sub.6)-alkenylcarbonyl, (C.sub.2-C.sub.6)-alkynylcarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkylaminocarbonyl, aminocarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, NR.sup.13R.sup.14, R.sup.13R.sup.14N(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphinyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkoxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkoxy, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, aryloxy, heteroaryloxy, heterocyclyloxy, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, hydroxyl, cyano, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, (C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkoxy, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkoxyimino, (C.sub.2-C.sub.6)-alkenyloxyimino, (C.sub.1-C.sub.6)-alkyloxyimino, aminocarbonyl and wherein heterocyclyl has q oxo groups, and wherein each of the aforementioned heterocyclic residues, in addition to the carbon atoms, has in each case p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, provided that R.sup.4 and R.sup.5 are not hydrogen at the same time, and wherein R.sup.4 and R.sup.5 together do not form an aromatic ring, R.sup.6, R.sup.7 are each independently hydrogen, cyano, halogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, or (C.sub.3-C.sub.8)-cycloalkyl, R.sup.8, R.sup.9 are each independently hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.2-C.sub.8)-alkenyloxy, (C.sub.2-C.sub.8)-alkynyloxy, NR.sup.13R.sup.14, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphinyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, and wherein heterocyclyl has q oxo groups, and wherein each of the aforementioned heterocyclic residues, in addition to the carbon atoms, has in each case p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, R.sup.10, R.sup.11 are each independently hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.3-C.sub.6)-cycloalkyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, phenyl, phenyl-(C.sub.1-C.sub.6)-alkyl, pyridinyl, furanyl, thienyl, pyridinyl-(C.sub.1-C.sub.6)-alkyl, thienyl-(C.sub.1-C.sub.6)-alkyl, furanyl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-alkylsulphinyl, (C.sub.1-C.sub.6)-alkylsulphonyl, and wherein heterocyclyl has q oxo groups, and wherein each of the aforementioned heterocyclic residues, in addition to the carbon atoms, has in each case p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, or R.sup.10 and R.sup.11, together with the sulphur atom to which they are attached, form a 3- to 6-membered unsaturated, partially saturated or saturated ring, which comprises in each case, in addition to the carbon atoms and in addition to the sulphur atom, p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, and wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-alkylsulphinyl or (C.sub.1-C.sub.6)-alkylsulphonyl, R.sup.12 is hydrogen, (C.sub.1-C.sub.6)-alkyl or (C.sub.1-C.sub.6)-alkylcarbonyl, R.sup.13, R.sup.14 are each independently hydrogen, (C.sub.1-C.sub.6)-alkyl, wherein these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-alkylsulphinyl, (C.sub.1-C.sub.6)-alkylsulphonyl, or R.sup.13 and R.sup.14, together with the nitrogen atom to which they are attached, form a 3- to 8-membered unsaturated, partially saturated or saturated ring, n is independently selected from 0, 1 or 2, m is independently selected from 0 or 1, p is independently selected from 0, 1, 2 or 3, q is independently selected from 0, 1 or 2, y is 0 or 1.

2. A compound of the formulae (G1) and (G2) and/or salt thereof according to claim 1 in which A is CR.sup.6R.sup.7, x is 0, 1 or 2, R.sup.1 is hydrogen, (C.sub.3-C.sub.6)-cycloalkyl, (C.sub.3-C.sub.6)-cycloalkenyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkenyl-(C.sub.1-C.sub.6)-alkyl, phenyl, pyridinyl, furanyl, thienyl wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-alkylsulphinyl, (C.sub.1-C.sub.6)-alkylsulphonyl, R.sup.2, R.sup.3 are each independently hydrogen, (C.sub.1-C.sub.6)-alkoxyphenyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthiocarbonyl, (C.sub.1-C.sub.6)-haloalkylthiocarbonyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-alkylsulphinyl-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-alkylsulphonyl-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-haloalkylcarbonyl, (C.sub.2-C.sub.6)-alkenylcarbonyl, (C.sub.2-C.sub.6)-alkynylcarbonyl, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.1-C.sub.6)-haloalkoxycarbonyl, (C.sub.2-C.sub.6)-alkenyloxycarbonyl, (C.sub.3-C.sub.6)-cycloalkylcarbonyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkylcarbonyl, phenylcarbonyl, phenyl-(C.sub.1-C.sub.6)-alkylcarbonyl, pyridinylcarbonyl, furanylcarbonyl, thienylcarbonyl, pyridinyl-(C.sub.1-C.sub.6)-alkylcarbonyl, furanyl-(C.sub.1-C.sub.6)-alkylcarbonyl, thienyl-(C.sub.1-C.sub.6)-alkylcarbonyl, heterocyclylcarbonyl, heterocyclyl-(C.sub.1-C.sub.6)-alkylcarbonyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-alkylsulphinyl, (C.sub.1-C.sub.6)-alkylsulphonyl, and wherein heterocyclyl has q oxo groups, and wherein each of the aforementioned heterocyclic residues, in addition to the carbon atoms, has in each case p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, or NR.sup.2R.sup.3 is NS(O).sub.nR.sup.10R.sup.11, R.sup.4, R.sup.5 are each independently hydrogen, formyl, oxytetrahydropyranmethyl, cyano, halogen, (C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylcarbonyloxy, (C.sub.1-C.sub.6)-alkylcarbonyloxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkyloxycarbonyloxy-(C.sub.1-C.sub.6)-alkyl, C.sub.6)-alkylsilyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl, (C.sub.3-C.sub.6)-cycloalkenyl, (C.sub.2-C.sub.6)-alkynylcarbonyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkylaminocarbonyl, (C.sub.2-C.sub.6)-alkenyl, aminocarbonyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.2-C.sub.6)-alkenylcarbonyl, imino-(C.sub.1-C.sub.6)-alkyl, phenyl, pyridinyl, furanyl, thienyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, hydroxyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkoxy, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkoxyimino, (C.sub.2-C.sub.6)-alkenyloxyimino, (C.sub.1-C.sub.6)-alkyloxyimino, aminocarbonyl, provided that R.sup.4 and R.sup.5 are not hydrogen at the same time, and wherein R.sup.4 and R.sup.5 together do not form an aromatic ring, R.sup.6 is hydrogen, R.sup.7 is hydrogen or (C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl, R.sup.10, R.sup.11 are each independently hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.3-C.sub.6)-cycloalkyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, phenyl, phenyl-(C.sub.1-C.sub.6)-alkyl, pyridinyl, furanyl, thienyl, furanyl-(C.sub.1-C.sub.6)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.6)-alkyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-alkylsulphinyl, (C.sub.1-C.sub.6)-alkylsulphonyl, and wherein heterocyclyl has q oxo groups, and wherein each of the aforementioned heterocyclic residues, in addition to the carbon atoms, has in each case p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, or R.sup.10 and R.sup.11, together with the sulphur atom to which they are attached, form a 3- to 6-membered unsaturated, partially saturated or saturated ring, which comprises in each case, in addition to the carbon atoms and in addition to the sulphur atom, p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, and wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-alkylsulphinyl or (C.sub.1-C.sub.6)-alkylsulphonyl, R.sup.12 is hydrogen, (C.sub.1-C.sub.6)-alkyl or (C.sub.1-C.sub.6)-alkylcarbonyl, R.sup.13, R.sup.14 are each independently hydrogen, (C.sub.1-C.sub.6)-alkyl, wherein these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-alkylsulphinyl, (C.sub.1-C.sub.6)-alkylsulphonyl, or R.sup.13 and R.sup.14, together with the nitrogen atom to which they are attached, form a 3- to 8-membered unsaturated, partially saturated or saturated ring, n is 0, m is independently selected from 0 or 1, p is independently selected from 0 or 1, q is independently selected from 0 or 1, y is 0 or 1.

3. A compound of the formulae (G1) and (G2) and/or salts thereof according to claim 1 in which A is CR.sup.6R.sup.7, x is 0, 1 or 2, R.sup.1 is hydrogen, cyclopropyl, cyclobutyl, cyclopentyl cyclohexyl or phenyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, R.sup.2, R.sup.3 are each independently hydrogen, (C.sub.1-C.sub.4)-alkoxyphenyl-(C.sub.1-C.sub.4)-alkyl, (C.sub.1-C.sub.4)-alkylcarbonyl, (C.sub.1-C.sub.4)-haloalkylcarbonyl, (C.sub.2-C.sub.5)-alkenylcarbonyl, (C.sub.2-C.sub.5)-alkynylcarbonyl, (C.sub.1-C.sub.4)-alkoxycarbonyl, (C.sub.1-C.sub.4)-haloalkoxycarbonyl, (C.sub.1-C.sub.4)-alkoxy-(C.sub.1-C.sub.4)-alkylcarbonyl, (C.sub.1-C.sub.4)-haloalkoxy-(C.sub.1-C.sub.4)-alkylcarbonyl, R.sup.4, R.sup.5 are each independently hydrogen, formyl, oxytetrahydropyranmethyl, cyano, halogen, (C.sub.1-C.sub.4)-alkoxycarbonyl, (C.sub.1-C.sub.4)-alkoxy-(C.sub.1-C.sub.4)-alkyl, (C.sub.1-C.sub.4)-alkylcarbonyloxy-(C.sub.1-C.sub.4)-alkyl, (C.sub.1-C.sub.4)-alkylcarbonyloxy, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.4)-alkylsilyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.4)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl, (C.sub.3-C.sub.6)-cycloalkenyl, (C.sub.2-C.sub.5)-alkynylcarbonyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.4)-alkylaminocarbonyl, (C.sub.2-C.sub.6)-alkenyl, aminocarbonyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.2-C.sub.5)-alkenylcarbonyl, (C.sub.1-C.sub.4)-alkoxycarbonylamino-(C.sub.1-C.sub.4)-alkyl, imino-(C.sub.1-C.sub.4)-alkyl, phenyl, pyridinyl, furanyl, thienyl, carboxythienyl, phenoxycarbonyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, hydroxyl, (C.sub.1-C.sub.4)-alkoxy, (C.sub.1-C.sub.4)-alkyl, (C.sub.1-C.sub.4)-alkoxycarbonyl, (C.sub.1-C.sub.4)-alkoxycarbonyl-(C.sub.1-C.sub.4)-alkoxy, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.4)-alkoxyimino, (C.sub.2-C.sub.5)alkenyloxyimino, (C.sub.1-C.sub.4)alkyloxyimino, aminocarbonyl, provided that R.sup.4 and R.sup.5 are not hydrogen at the same time, and wherein R.sup.4 and R.sup.5 together do not form an aromatic ring, R.sup.6 is hydrogen, R.sup.7 is hydrogen or methyl, y is 0 or 1.

4. An herbicidal and/or plant growth-regulating composition, wherein said composition comprises one or more compounds of the formulae (G1) or (G2) and/or salts thereof as defined in claim 1, and one or more further substances selected from groups (i) and/or (ii): (i) one or more further agrochemically active substances, optionally selected from the group consisting of insecticides, acaricides, nematicides, further herbicides, fungicides, safeners, fertilizers and/or further growth regulators, (ii) one or more formulation auxiliaries customary in crop protection.

5. A product comprising one or more compounds of the formulae (G1) or (G2) and/or salts thereof according to claim 1 and/or a composition thereof for controlling one or more harmful plants or for regulating the growth of one or more plants.

6. A product comprising one or more compounds of the formulae (G1) or (G2) and/or salts thereof according to claim 1 and/or a composition thereof for controlling fungi.

7. A product comprising one or more compounds of the formulae (G1) or (G2) and/or salts thereof according to claim 1 and/or a composition thereof for controlling one or more pests.

8. A method for controlling fungi, one or more pests, one or more harmful plants or for regulating the growth of one or more plants, comprising applying an effective amount of one or more compounds of the formulae (G1) or (G2) and/or salts thereof, as defined in claim 1, or a composition thereof, to the plants, seeds of plants, soil in which or on which plants grow or an area under cultivation.

Description

EXAMPLES

(1) In an exemplary manner, some synthesis examples of compounds of the general formulae (G1) and (G2) are described below. In the examples, the amounts (including percentages) refer to the weight, unless especially stated otherwise.

(2) The symbols > and < mean greater than and smaller than, respectively. The symbol > means greater than or equal to, the symbol < means smaller than or equal to.

(3) If, in the context of the description and the examples, the terms R and S are given for the absolute configuration on a centre of chirality of the stereoisomers of the formulae (G1) and (G2), this RS nomenclature follows, unless defined differently, the Cahn-Ingold-Prelog rule.

(4) In the context of the present invention and in the Tables 1 to 3 mentioning specific and preferred compounds according to the present invention, the following abbreviations are used: H=hydrogen Me=methyl or CH.sub.3 Et=ethyl Pr=propyl Bu=butyl nAlkyl=n-alkyl, e.g. nPr=n-propyl cAlkyl=cycloalkyl, e.g. cPr=cyclopropyl, cHexyl=cyclohexyl iAlkyl=isooalkyl, e.g. iPr=isopropyl tAlkyl=tertiary alkyl, e.g. tBu=tert-butyl Ac=acetyl F, Cl, Br, I=fluorine, chlorine, bromine and iodine, respectively, in accordance with the conventional chemical atom symbol MeO or OMe=methoxy CN=cyano NO.sub.2=nitro Ph=phenyl diHal=diHal, e.g. diF=difluoro triHal=triHal, e.g. triF=trifluoro CCH=ethinyl (CCH)

(5) The position of a substituent, e.g. at the phenyl ring in position 2, is stated as a prefix to the symbol or the abbreviation of the radical, for example 2-Cl=2-chloro 2-Me=2-methyl

(6) Numerations of the substituent positions for di- or trisubstituted substitution patterns are analogously stated as a prefix, for example 2,3-Cl.sub.2=2,3-dichloro (e.g. as substitution at the phenyl ring) 2,4-diF=2,4-difluoro (e.g. as substitution at the phenyl ring) 2,4-F.sub.2=2,4-difluoro (e.g. as substitution at the phenyl ring) 2,4,6-triF=2,4,6-trifluoro (e.g. as substitution at the phenyl ring) 2-F-4-Cl=2-fluoro, 4-chloro (e.g. as substitution at the phenyl ring) 5-F-2-Me=5-fluoro, 2-methyl (e.g. as substitution at the phenyl ring)

(7) Other abbreviations are to be understood analogously to the examples stated above.

(8) In addition, the customary chemical symbols and formulae apply, such as, for example, CH.sub.2 for methylene or CF.sub.3 for trifluoromethyl or OH for hydroxyl.

(9) Correspondingly, composite meanings are defined as composed of the abbreviations mentioned, for example 4-CF.sub.3-cHexyl=4-trifluoromethyl-cyclohexyl Further, the following abbreviations are used: DCM=dichloromethane DMF=dimethylformamide DMSO=dimethylsulfoxide T3P=propylphosphonic anhydride THF=tetrahydrofuran

(10) NMR-Peak lists

(11) 1H-NMR data of selected examples are written in form of 1H-NMR-peak lists. To each signal peak are listed the -value in ppm and the signal intensity in round brackets. Between the -valuesignal intensity pairs are semicolons as delimiters.

(12) The peak list of an example has therefore the form:

(13) 1 (intensity1); 2 (intensity2); . . . ; i (intensityi); . . . ; n (intensityn)

(14) Intensity of sharp signals correlates with the height of the signals in a printed example of a NMR spectrum in cm and shows the real relations of signal intensities. From broad signals several peaks or the middle of the signal and their relative intensity in comparison to the most intensive signal in the spectrum can be shown.

(15) For calibrating chemical shift for 1H spectra, tetramethylsilane and/or the chemical shift of the solvent was used, especially in the case of spectra measured in DMSO (Dimethyl sulphoxide). Therefore in NMR peak lists, tetramethylsilane peak can occur, but not necessarily

(16) The 1H-NMR peak lists are similar to classical 1H-NMR prints and contains therefore usually all peaks, which are listed at classical NMR-interpretation.

(17) Additionally they can show like classical 1H-NMR prints signals of solvents, stereoisomers of the target compounds, which are also object of the invention, and/or peaks of impurities.

(18) To show compound signals in the delta-range of solvents and/or water the usual peaks of solvents, for example peaks of DMSO in DMSO-D.sub.6 and the peak of water are shown in our 1H-NMR peak lists and have usually on average a high intensity.

(19) The peaks of stereoisomers of the target compounds and/or peaks of impurities have usually on average a lower intensity than the peaks of target compounds (for example with a purity>90%).

(20) Such stereoisomers and/or impurities can be typical for the specific preparation process. Therefore their peaks can help to recognize the reproduction of our preparation process via side-products-fingerprints.

(21) An expert, who calculates the peaks of the target compounds with known methods (MestreC, ACD-simulation, but also with empirically evaluated expectation values) can isolate the peaks of the target compounds as needed optionally using additional intensity filters. This isolation would be similar to relevant peak picking at classical 1H-NMR interpretation.

(22) Further details of NMR-data description with peak lists can be found in the publication Citation of NMR Peaklist Data within Patent Applications of the Research Disclosure Database Number 564025.

(23) The compounds according to the present invention, such as described in the Tables 1 to 3, are obtained according to or analogously to the following chemical synthesis examples.

(A) Chemical Synthesis Examples

Selected Examples

1. Synthesis of 3-amino-6-(cyclohexylmethyl)-4-(4-fluorophenyl)isothiazolo[5,4-c]pyridin-7-one (Compound No. I-71)

(24) Scheme 9 illustrates the steps (i) to (viii) described in detail in the examples 1.1 to 1.8:

(25) ##STR00030##

1.1 Step (i)=Synthesis of methyl 3-amino-4-prop-1-ynyl-isothiazole-5-carboxylate

(26) To a stirred degassed solution of 650 mg of ester 1 (2.3 mmol) in dry DMF (11 mL) were successively added 161 mg of palladium (II) diphenylphosphine dichloride (0.23 mmol), 44 mg of copper iodide (0.23 mmol), 0.64 mL of triethylamine (4.6 mmol) and 0.65 mL of ethynyltrimethylsilane (4.6 mmol). The reaction mixture was then stirred at 100 degrees for 1 h. The solution was cooled to rt and partitioned between a saturated aqueous solution of ammonium chloride and 10% dichloromethane in heptane. The aqueous phase was extracted twice with 10% dichloromethane in heptane and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by column chromatography. Yield: 486 mg (83% of theory).

(27) .sup.1H-NMR (400 MHz, CDCl.sub.3 6, ppm) 4.92 (br. s, 2H), 3.92 (s, 3H), 0.30 (s, 9H).

1.2 Step (ii)=Synthesis of 3-amino-4-ethynyl-isothiazole-5-carboxylic acid

(28) To a stirred solution of 8.0 g of ester 2 (31 mmol) in THF (80 mL) and MeOH (80 mL) was added 42 mL of a 2 M aqueous solution of sodium hydroxide (94 mmol). The reaction mixture was then stirred at rt for 2 h. The mixture was concentrated and the residue partitioned between a 2 M aqueous solution of HCl and EtOAc. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered and concentrated. The corresponding acid was engaged in the next step without further purification. Yield: 5.2 g (99% of theory).

(29) .sup.1H-NMR (400 MHz, DMSO , ppm) 13.9 (br. s, 1H), 6.42 (br. s, 2H), 4.68 (s, 1H).

1.3 Step (iii)=Synthesis of 3-amino-N-(cyclohexylmethyl)-4-ethynyl-isothiazole-5-carboxamide

(30) To a stirred solution of 3.0 g of acid 3 (18 mmol) in THF (93 mL) was added successively 16 mL of T3P (27 mmol, 50% in THF), 6.2 mL of triethylamine (45 mmol) and 3.5 mL of cyclohexylmethanamine (27 mmol). The reaction mixture was then stirred at 55 degrees for 2 h. The mixture was concentrated and the residue partitioned between a 2 M aqueous solution of HCl and EtOAc. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by column chromatography. Yield: 3.5 g (73% of theory).

(31) .sup.1H-NMR (400 MHz, DMSO , ppm) 8.08 (t, 1H), 6.40 (br. s, 2H), 4.82 (s, 1H), 3.12 (t, 2H), 1.72-1.61 (m, 5H), 1.53-1.48 (m, 1H), 1.22-1.11 (m, 3H), 0.98-0.92 (m, 2H).

1.4 Step (iv)=Synthesis of 3-amino-6-(cyclohexylmethyl)isothiazolo[5,4-c]pyridin-7-one

(32) To a stirred solution of 5.8 g of alkyne 4 (22 mmol) in THF (51 mL) was added 55 mL of a 1 M solution of tetrabutylammonium fluoride in THF (55 mmol). The reaction mixture was then stirred at rt for 1 h. Water was added and the resulting precipitate was collected by filtration and washed once with DCM. Yield: 4.5 g (75% of theory).

(33) .sup.1H-NMR (400 MHz, DMSO , ppm) 7.54 (d, 1H), 6.86 (d, 1H), 6.83 (br. s, 2H), 3.83 (d, 2H), 1.82-1.53 (m, 6H), 1.20-1.00 (m, 3H), 0.97-0.92 (m, 2H).

1.5 Step (v)=Synthesis of 6-(cyclohexylmethyl)-3-(dimethylamino)isothiazolo[5,4-c]pyridin-7-one

(34) To a stirred suspension of 5.1 g of amine 5 (19 mmol) in THF (150 mL) was added successively 47 mg of dimethylaminopyridine (0.39 mmol), 8.1 mL of triethylamine (58 mmol) and 11 g of di-tert-butyldicarbonate (48 mmol). The reaction mixture was then stirred at rt for 2 h. The mixture was partitioned between a saturated aqueous solution of ammonium chloride and EtOAc. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by column chromatography. Yield: 7.7 g (86% of theory).

(35) .sup.1H-NMR (400 MHz, DMSO , ppm) 7.66 (d, 1H), 6.65 (d, 1H), 3.89 (d, 2H), 1.83-1.50 (m, 6H), 1.35 (s, 18H), 1.23-1.10 (m, 3H), 1.07-0.92 (m, 2H).

1.6 Step (vi)=Synthesis of 4-bromo-6-(cyclohexylmethyl)-3-(dimethylamino)isothiazolo[5,4-c]pyridin-7-one

(36) To a stirred suspension of 7.7 g of pyridone 6 (17 mmol) in DMF (168 mL) was added 3.3 g of N-bromosuccinimide (18 mmol) and the reaction mixture was then stirred at rt for 4 h. The mixture was concentrated and the residue partitioned between water and EtOAc. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by column chromatography. Yield: 8.0 g (88% of theory).

(37) .sup.1H-NMR (400 MHz, DMSO , ppm) 8.05 (s, 1H), 3.89 (d, 2H), 1.83-1.50 (m, 6H), 1.35 (s, 18H), 1.23-1.10 (m, 3H), 1.07-0.92 (m, 2H).

1.7 Step (vii)=Synthesis of 3-amino-4-bromo-6-(cyclohexylmethyl)isothiazolo[5,4-c]pyridin-7-one

(38) To a stirred solution of 8.0 g of carbamate 7 (15 mmol) in DCM (135 mL) was slowly added 7.9 mL of trifluoroacetic acid (103 mmol) and the reaction mixture was then stirred at rt for 3 h. The mixture was concentrated and the residue partitioned between EtOAc and a 2 M aqueous solution of sodium hydroxide. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered and concentrated. Yield: 4.7 g (93% of theory).

(39) .sup.1H-NMR (400 MHz, DMSO , ppm) 7.86 (s, 1H), 6.55 (br. s, 2H), 3.82 (d, 2H), 1.81-1.53 (m, 6H), 1.19-1.10 (m, 3H), 1.02-0.93 (m, 2H).

1.8 Step (viii)=Synthesis of 3-amino-6-(cyclohexylmethyl)-4-(4-fluorophenyl)isothiazolo[5,4-c]pyridin-7-one (I-71)

(40) To a stirred and degassed solution of 0.19 g of bromo pyridone 8 (0.56 mmol) in THF (3.0 mL) was successively added 0.32 g of sodium carbonate (3.0 mmol), 0.20 g of 4-fluorophenylboronic acid (1.5 mmol) and 78 mg of palladium (II) diphenylphosphine dichloride (0.11 mmol). The reaction mixture was then stirred under argon at 80 degrees for 3 h. The mixture was cooled to rt and partitioned between EtOAc and a 2 M aqueous solution of HCl. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by column chromatography. Yield: 54 mg (27% of theory).

(41) .sup.1H-NMR (400 MHz, DMSO , ppm) 7.49 (dd, 2H), 7.43 (s, 1H), 7.35 (dd, 2H), 5.45 (br. s, 2H), 3.87 (d, 2H), 1.86-1.78 (m, 1H), 1.70-1.58 (m, 5H), 1.24-1.13 (m, 3H), 1.04-0.99 (m, 2H).

2. Synthesis of N-[6-(cyclohexylmethyl)-5-isopropyl-7-oxo-isothiazolo[5,4-c]pyridin-3-yl]-2,2,3,3,3-pentafluoro-propanamide (Compound No. I-21)

(42) Scheme 10 illustrates the steps (i) to (v) described in detail in the examples 2.1 to 2.5:

(43) ##STR00031##

2.1 Step (i)=Synthesis of 3-amino-4-iodo-isothiazole-5-carboxylic acid

(44) To a stirred solution of 21 g of ester 1 (72 mmol) in THF (0.15 L) and MeOH (0.15 L) was added 0.11 L of a 2 M aqueous solution of sodium hydroxide (0.22 mol). The reaction mixture was then stirred at rt for 2 h. The mixture was concentrated and the residue partitioned between a 2 M aqueous solution of HCl and EtOAc. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered and concentrated. The corresponding acid was engaged in the next step without further purification. Yield: 19 g (97% of theory).

(45) .sup.1H-NMR (400 MHz, DMSO , ppm) 13.9 (br. s, 1H), 6.32 (br. s, 2H).

2.2 Step (ii)=Synthesis of 3-amino-N-(cyclohexylmethyl)-4-iodo-isothiazole-5-carboxamide

(46) To a stirred solution of 10 g of acid 10 (37 mmol) in THF (0.13 L) was added successively 33 mL of T3P (55 mmol, 50% in THF), 15 mL of triethylamine (0.11 mol) and 5.3 mL of cyclohexylmethanamine (41 mmol). The reaction mixture was then stirred at 55 degrees for 2 h. The mixture was quenched by addition of a 2 M aqueous solution of HCl and the resulting solid was collected by filtration and dried at air. Yield: 12 g (91% of theory).

(47) .sup.1H-NMR (400 MHz, DMSO , ppm) 8.42 (t, 1H), 6.24 (br. s, 2H), 3.06 (t, 2H), 1.75-1.47 (m, 6H), 1.24-1.12 (m, 3H), 0.98-0.89 (m, 2H).

2.3 Step (iii)=Synthesis of 3-amino-N-(cyclohexylmethyl)-4-(3-methylbut-1-ynyl)isothiazole-5-carboxamide

(48) To a stirred degassed solution of 1.0 g of amide 11 (2.7 mmol) in 15 mL of triethylamine (0.11 mol) were successively added 0.19 g of palladium (II) diphenylphosphine dichloride (0.27 mmol), 52 mg of copper iodide (0.27 mmol) and 0.39 g of 3-methyl-1-butyne (5.5 mmol). The reaction mixture was then stirred at 50 degrees for 2 h. The solution was cooled to room temperature and partitioned between a 2 M aqueous solution of HCl and EtOAc. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by column chromatography. Yield: 0.63 g (76% of theory).

(49) .sup.1H-NMR (400 MHz, DMSO , ppm) 7.87 (t, 1H), 6.30 (br. s, 2H), 3.14 (t, 2H), 2.88 (hept, 1H), 1.74-1.47 (m, 6H), 1.25 (d, 6H), 1.24-1.16 (m, 3H), 0.95-0.92 (m, 2H).

2.4 Step (iv)=Synthesis of 3-amino-6-(cyclohexylmethyl)-5-isopropyl-isothiazolo[5,4-c]pyridin-7-one

(50) To a stirred solution of 0.60 g of alkyne 12 (2.0 mmol) in THF (8.0 mL) was added 5.9 mL of a 1 M solution of tetrabutylammonium fluoride in THF (5.9 mmol). The reaction mixture was then stirred at rt for 4 h. The mixture was partitioned between a saturated aqueous solution of sodium chloride and EtOAc. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by column chromatography. Yield: 0.40 g (66% of theory).

(51) .sup.1H-NMR (400 MHz, DMSO , ppm) 6.94 (s, 1H), 6.84 (br. s, 2H), 4.02 (m, 2H), 3.11 (hept, 1H), 1.66-1.49 (m, 6H), 1.25 (d, 6H), 1.19-1.04 (m, 5H).

2.5 Step (v)=Synthesis of N-[6-(cyclohexylmethyl)-5-isopropyl-7-oxo-isothiazolo[5,4-c]pyridin-3-yl]-2,2,3,3,3-pentafluoro-propanamide (I-21)

(52) To a stirred suspension of 80 mg of pyridone 13 (0.26 mmol) in DCM (6.0 mL) was added successively 3.2 mg of dimethylaminopyridine (0.03 mmol), 73 L of triethylamine (0.52 mmol) and 0.16 g of pentafluoropropanoyl-pentafluoropropanoate (0.52 mmol). The reaction mixture was then stirred at rt for 4 h. The mixture was partitioned between water and DCM. The aqueous phase was extracted twice with DCM and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by column chromatography. Yield: 0.11 g (96% of theory).

(53) .sup.1H-NMR (400 MHz, DMSO , ppm) 12.5 (s, 1H), 6.56 (s, 1H), 4.02 (m, 2H), 3.17 (hept, 1H), 1.67-1.51 (m, 6H), 1.23 (d, 6H), 1.19-1.06 (m, 5H).

(54) NMR Peak Lists

(55) NMR peak lists for compounds according to formulae (G1) and (G2) in the context of the present invention. The numbering refers to Tables 1 to 4 above.

(56) TABLE-US-00005 Example I-001: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 12.048(0.7); 7.278(0.7); 7.264(3.9); 7.259(3.9); 7.250(3.5); 7.240(1.1); 7.221(15.5); 7.202(0.5); 6.903(2.3); 6.881(3.6); 6.810(0.5); 6.803(4.0); 6.798(1.2); 6.786(1.0); 6.782(2.6); 4.219(1.6); 4.207(3.3); 4.184(1.1); 4.173(1.0); 4.158(0.4); 3.713(16.0); 3.319(47.2); 2.675(0.3); 2.670(0.4); 2.666(0.3); 2.523(1.4); 2.510(28.0); 2.506(56.4); 2.501(74.8); 2.496(54.9); 2.492(27.3); 2.332(0.3); 2.328(0.5); 2.323(0.4); 0.000(2.6) Example I-002: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 11.802(0.5); 7.954(0.4); 7.941(1.0); 7.927(0.5); 7.506(16.0); 7.331(2.1); 7.310(2.4); 6.906(2.7); 6.902(1.0); 6.890(1.0); 6.885(2.6); 6.877(0.3); 6.091(0.5); 6.079(1.2); 6.067(0.5); 5.754(0.4); 4.529(1.9); 4.516(1.9); 4.384(1.7); 4.372(1.7); 3.731(12.7); 3.721(0.8); 3.358(0.4); 3.326(105.0); 2.510(15.2); 2.506(30.5); 2.501(40.4); 2.497(29.4); 2.492(14.4); 0.008(0.4); 0.000(9.4); 0.008(0.4) Example I-003: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 11.975(1.1); 7.440(0.7); 7.424(2.0); 7.406(3.5); 7.379(4.7); 7.360(2.1); 6.907(2.6); 6.885(4.3); 6.819(4.6); 6.797(2.8); 4.194(2.7); 4.182(4.0); 4.137(1.0); 4.124(1.2); 3.725(16.0); 3.518(14.0); 3.318(81.3); 2.670(0.6); 2.501 (108.4); 2.328(0.6); 1.988(1.0); 1.398(0.4); 1.175(0.5); 0.000(12.1) Example I-004: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.308(2.5); 7.286(2.7); 6.923(0.5); 6.916(3.4); 6.911(1.2); 6.899(1.2); 6.894(3.3); 6.887(0.6); 6.872(0.4); 4.508(2.3); 4.494(2.2); 3.876(10.7); 3.811(10.2); 3.753(0.4); 3.735(16.0); 3.724(1.4); 3.674(0.5); 3.656(0.8); 3.589(0.4); 3.386(0.3); 3.320(614.7); 3.287(0.5); 2.679(0.7); 2.675(1.5); 2.670(2.1); 2.666(1.6); 2.661(0.7); 2.524(4.8); 2.519(7.7); 2.510(129.3); 2.506(275.1); 2.501(369.1); 2.496(261.7); 2.492(121.8); 2.332(1.5); 2.328(2.1); 2.323(1.5); 2.319(0.7); 1.398(2.8); 1.236(0.4); 0.000(3.3) Example I-005: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 12.008(1.5); 7.330(2.2); 7.324(3.9); 7.318(5.2); 7.280(2.4); 7.271(2.5); 7.262(1.8); 7.256(1.4); 7.222(16.0); 7.188(0.4); 5.755(0.6); 5.129(3.0); 3.712(0.4); 3.318(400.6); 2.670(1.8); 2.505(230.0); 2.501(313.5); 2.496(245.6); 2.327(1.9); 1.988(0.5); 1.298(0.4); 1.258(0.6); 1.235(4.5); 1.174(0.3); 0.853(0.5); 0.146(0.6); 0.008(4.6); 0.000(123.3); 0.150(0.6) Example I-006: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.05 (1H), 4.15-4.05 (2H), 3.92-3.85 (2H), 3.30-3.20 (1H), 2.95- 2.90 (1H), 2.70-2.60 (1H), 1.85-1.60 (6H), 1.51 (9H), 1.47 (9H), 1.32-0.92 (5H) Example I-007: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.27 (2H), 4.98 (1H), 3.87-3.84 (1H), 3.68-3.67 (1H), 3.45-3.42 (1H), 3.22-3.19 (1H), 2.99-2.96 (1H), 2.74-2.69 (2H), 1.73-1.60 (5H), 1.24-0.87 (6H) Example I-008: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.916(0.3); 6.894(0.5); 6.418(3.2); 3.898(0.4); 3.880(16.0); 3.863(14.9); 3.840(0.5); 3.820(0.9); 3.812(1.1); 3.782(0.4); 3.759(1.0); 3.754(1.1); 3.746(0.5); 3.735(1.6); 3.723(1.3); 3.716(1.6); 3.706(0.8); 3.698(0.5); 3.692(0.5); 3.683(0.4); 3.675(0.4); 3.652(0.4); 3.649(0.3); 3.642(0.4); 3.629(0.5); 3.620(0.5); 3.441(0.5); 3.319(212.2); 2.675(0.8); 2.670(1.1); 2.666(0.8); 2.524(2.6); 2.510(60.2); 2.506(127.6); 2.501(179.3); 2.497(134.3); 2.492(64.9); 2.333(0.8); 2.328(1.0); 2.324(0.8); 1.896(0.4); 1.433(0.3); 1.351(0.4); 1.336(0.6); 1.298(1.3); 1.258(1.9); 1.249(1.0); 1.244(1.3); 1.235(3.5); 0.854(0.5); 0.008(2.0); 0.000(61.7); 0.008(2.3) Example I-009: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 11.948(0.3); 11.881(0.3); 11.761(0.9); 7.556(1.1); 7.549(1.2); 7.512(16.0); 7.476(2.0); 7.470(2.0); 7.435(1.1); 7.430(1.1); 7.368(0.6); 7.349(0.5); 7.332(0.5); 7.310(0.5); 7.257(0.4); 7.240(0.5); 7.228(0.7); 7.186(0.4); 7.160(0.3); 7.143(0.4); 7.101(0.7); 7.086(0.5); 7.078(0.4); 7.066(0.4); 6.998(0.5); 6.995(0.5); 6.972(0.8); 6.954(0.4); 6.938(0.4); 6.929(0.3); 6.884(0.5); 6.855(0.4); 6.825(2.6); 6.445(0.3); 6.423(0.4); 6.243(0.4); 5.950(0.6); 5.938(1.3); 5.928(0.7); 4.372(2.4); 4.360(2.3); 4.322(0.4); 4.308(0.6); 3.817(1.0); 3.808(0.4); 3.762(0.7); 3.737(0.7); 3.731(1.0); 3.712(0.4); 3.699(0.4); 3.676(0.3); 3.662(0.4); 3.643(0.6); 3.606(1.2); 3.322(502.8); 3.227(0.4); 2.671(2.9); 2.506(403.4); 2.502(523.8); 2.497(395.9); 2.398(0.6); 2.350(0.4); 2.328(3.1); 2.324(2.4); 2.299(0.4); 2.282(0.3); 1.231(1.9); 1.208(0.9); 0.850(0.4); 0.000(2.8) Example I-010: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 8.313(3.8); 7.780(0.5); 7.766(1.0); 7.751(0.5); 7.299(2.6); 7.277(3.0); 6.898(0.4); 6.890(3.5); 6.885(1.2); 6.874(1.1); 6.869(3.2); 6.861(0.4); 6.762(3.2); 4.486(2.1); 4.472(2.4); 3.722(16.0); 3.691(1.4); 3.675(3.1); 3.659(1.5); 3.319(11.4); 3.296(0.7); 2.678(1.3); 2.662(2.6); 2.646(1.1); 2.524(0.4); 2.510(11.8); 2.506(24.8); 2.501(34.3); 2.497(25.7); 2.492(12.4); 0.008(0.5); 0.000(15.5); 0.008(0.6) Example I-011: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 11.566(0.4); 7.925(0.5); 7.310(1.2); 7.289(1.3); 7.099(1.2); 7.097(1.1); 6.901(1.5); 6.896(0.4); 6.884(0.5); 6.880(1.3); 4.510(1.0); 4.496(1.0); 3.726(6.5); 3.317(11.5); 2.524(0.4); 2.511(8.0); 2.506(16.5); 2.502(22.7); 2.497(16.7); 2.493(7.9); 1.989(0.8); 1.398(3.0); 1.175(0.4); 0.323(0.7); 0.315(16.0); 0.306(0.6); 0.000(6.4) Example I-012: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 11.933(1.4); 7.514(3.9); 7.507(5.1); 7.499(4.9); 7.384(2.5); 7.377(2.9); 7.374(2.5); 7.368(2.5); 7.361(2.0); 5.176(3.3); 3.725(0.6); 3.520(16.0); 3.320(91.6); 2.670(0.6); 2.506(76.4); 2.501(97.6); 2.497(77.0); 2.328(0.6); 0.000(10.8) Example I-013: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 16.689(0.8); 8.313(5.1); 3.829(1.0); 3.724(1.2); 3.438(1.0); 3.417(0.8); 3.404(1.0); 3.316(1728.3); 2.674(12.0); 2.670(16.0); 2.666(12.0); 2.633(1.4); 2.510(983.2); 2.506(1932.2); 2.501(2601.2); 2.497(1979.8); 2.387(1.3); 2.373(0.9); 2.332(11.5); 2.328(15.5); 2.323(11.8); 1.350(0.9); 1.298(0.8); 1.276(0.8); 1.259(1.4); 1.235(3.2); 0.853(0.8); 0.483(0.8); 0.146(7.6); 0.039(1.3); 0.008(70.4); 0.000(1641.3); 0.008(73.5); 0.075(0.8); 0.150(7.7); 3.613(0.8) Example I-014: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 11.600(4.8); 9.258(0.4); 8.315(0.6); 7.393(0.4); 7.372(0.5); 7.176(0.4); 7.156(0.4); 6.992(0.5); 6.968(0.5); 6.890(0.5); 6.875(0.4); 6.854(0.4); 6.820(0.4); 6.746(15.7); 6.711(0.7); 6.677(14.0); 4.792(4.5); 4.779(9.9); 4.766(4.8); 4.099(0.7); 4.086(0.8); 3.954(0.4); 3.762(2.1); 3.753(0.6); 3.732(1.3); 3.722(2.0); 3.700(4.4); 3.683(11.2); 3.669(11.5); 3.654(4.6); 3.496(0.4); 3.482(0.5); 3.429(0.6); 3.417(0.8); 3.404(0.6); 3.324(318.2); 3.216(0.4); 3.176(4.0); 3.162(3.8); 2.679(8.6); 2.663(16.0); 2.646(7.2); 2.502(405.0); 2.498(308.4); 2.329(2.4); 1.236(0.6); 0.146(1.3); 0.008(12.5); 0.000(299.4); 0.008(11.0); 0.150(1.4) Example I-015: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 11.607(3.3); 6.735(12.3); 6.625(16.0); 6.270(0.7); 3.602(1.0); 3.315(46.5); 2.671(0.6); 2.525(2.3); 2.520(3.3); 2.512(37.7); 2.507(79.4); 2.502(108.9); 2.498(76.7); 2.493(35.3); 2.457(0.8); 2.452(1.0); 2.445(1.2); 2.429(1.0); 2.401(8.5); 2.384(8.8); 2.334(0.6); 2.329(0.7); 2.325(0.5); 1.776(0.6); 1.768(0.6); 1.760(1.3); 1.649(10.3); 1.623(8.1); 1.238(0.9); 1.207(2.4); 1.176(4.0); 1.156(4.4); 1.108(1.1); 0.970(1.3); 0.943(3.4); 0.937(3.3); 0.917(3.0); 0.887(0.9); 0.000(4.5) Example I-016: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 10.9 (1H), 4.15-4.05 (1H), 3.85-3.78 (1H), 3.59-3.52 (1H), 3.05-2.95 (1H), 2.89-2.79 (1H), 1.47 (9H), 1.46 (9H) Example I-017: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 11.741(1.3); 8.313(1.2); 7.761(2.2); 7.090(3.9); 3.886(16.0); 3.315(151.5); 2.670(3.4); 2.618(0.4); 2.505(411.8); 2.501(552.6); 2.497(428.1); 2.332(2.4); 2.328(3.2); 2.324(2.5); 0.000(29.4) Example I-018: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.766(16.0); 6.748(16.0); 3.921(8.0); 3.903(7.9); 3.311(287.1); 3.261(1.7); 2.670(3.0); 2.510(207.1); 2.505(414.0); 2.501(551.4); 2.496(400.3); 2.492(194.4); 2.451(5.4); 2.428(46.7); 2.328(3.9); 1.771(2.5); 1.658(5.8); 1.598(3.7); 1.545(5.7); 1.513(5.6); 1.144(9.0); 1.089(3.5); 1.059(4.5); 1.034(3.5); 0.936(1.5); 0.000(27.3) Example I-019: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO): = 19.088(3.8); 15.405(3.7); 8.440(3.7); 8.308(5.4); 7.439(4.3); 7.094(3.9); 6.907(6.2); 6.844(3.7); 6.803(4.4); 3.813(4.4); 3.770(4.9); 3.732(9.2); 3.724(4.1); 3.697(10.1); 3.462(4.3); 3.448(3.8); 3.358(4.9); 3.304(1645.2); 2.611(14.9); 2.518(32.9); 2.515(32.7); 2.503(1705.9); 2.500(2382.3); 2.498(1947.4); 2.384(14.4); 2.173(6.5); 1.768(4.5); 1.750(5.4); 1.737(5.4); 1.706(6.0); 1.702(4.9); 1.237(3.8); 1.212(4.1); 1.192(4.3); 1.171(4.6); 1.147(3.9); 1.133(5.4); 1.116(16.0); 1.106(15.3); 0.985(4.9); 0.964(5.5); 0.000(69.0); 0.874(3.8) Example I-020: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.183(1.1); 6.264(0.6); 3.811(1.0); 3.793(1.0); 2.803(0.7); 2.802(0.7); 2.785(0.7); 2.511(3.7); 2.507(7.9); 2.502(11.0); 2.498(7.6); 2.493(3.3); 1.193(1.3); 1.174(3.0); 1.156(1.4); 1.150(0.7); 1.070(16.0); 0.858(0.5); 0.000(4.1) Example I-021: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 12.466(1.0); 6.565(10.0); 5.755(3.1); 4.023(1.2); 3.316(7.8); 3.185(0.9); 3.168(1.3); 3.152(1.0); 2.521(0.7); 2.512(14.2); 2.508(31.6); 2.503(44.8); 2.498(31.4); 2.494(14.1); 1.666(2.0); 1.592(1.0); 1.539(1.7); 1.514(1.5); 1.241(16.0); 1.225(15.2); 1.194(0.5); 1.176(0.5); 1.135(2.5); 1.118(3.3); 1.095(1.7); 1.064(0.9); 0.858(1.7); 0.840(0.6); 0.000(5.2) Example I-022: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 12.414(2.0); 6.443(7.8); 5.755(16.0); 4.198(6.2); 4.180(6.5); 3.316(4.8); 2.526(1.3); 2.521(1.8); 2.512(22.3); 2.508(48.5); 2.503(68.4); 2.498(49.2); 2.494(23.8); 2.453(1.1); 2.098(1.1); 2.085(1.8); 2.071(1.2); 2.051(0.6); 1.990(0.6); 1.904(1.1); 1.670(3.2); 1.603(4.7); 1.577(3.2); 1.234(3.4); 1.176(1.8); 1.158(4.6); 1.138(6.4); 1.104(3.8); 1.092(5.6); 1.088(5.9); 1.072(5.8); 1.067(5.5); 1.057(2.2); 0.875(0.8); 0.858(2.7); 0.840(1.0); 0.780(1.5); 0.765(4.7); 0.756(4.5); 0.741(1.5); 0.008(1.4); 0.000(46.3); 0.008(1.7) Example I-023: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.939(11.7); 6.836(6.5); 4.038(0.6); 4.020(0.8); 3.992(1.1); 3.334(59.5); 3.144(1.2); 3.127(1.7); 3.110(1.2); 3.094(0.5); 2.672(0.7); 2.526(1.7); 2.521(2.5); 2.512(37.1); 2.508(81.9); 2.503(114.3); 2.498(79.9); 2.494(34.8); 2.458(0.7); 2.453(0.8); 2.334(0.5); 2.330(0.7); 2.325(0.5); 1.990(1.4); 1.664(2.8); 1.655(2.7); 1.590(1.3); 1.518(2.2); 1.491(2.0); 1.254(16.0); 1.237(16.0); 1.193(0.7); 1.175(1.1); 1.157(1.1); 1.123(3.0); 1.100(3.3); 1.072(2.1); 1.042(1.1); 0.008(1.0); 0.000(39.8); 0.008(1.2) Example I-024: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.16 (1H), 6.76 (1H), 4.05 (2H), 3.12-3.08 (1H), 2.68-2.50 (2H), 1.74-1.62 (6H), 1.32-1.08 (14H) Example I-025: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.262(80.3); 6.662(2.2); 5.299(3.8); 4.251(5.4); 4.233(5.5); 2.611(0.7); 2.007(0.5); 1.958(1.3); 1.951(1.4); 1.940(2.2); 1.932(1.5); 1.924(1.6); 1.919(1.4); 1.905(0.9); 1.717(2.5); 1.701(2.6); 1.673(3.2); 1.588(4.4); 1.304(7.7); 1.285(16.0); 1.266(7.7); 1.219(1.0); 1.193(3.4); 1.172(4.0); 1.133(1.9); 1.104(1.5); 1.090(1.0); 1.078(3.4); 1.075(3.9); 1.058(3.2); 1.054(3.3); 0.840(1.1); 0.826(3.5); 0.812(3.2); 0.800(0.9); 0.000(6.1) Example I-026: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.805(7.9); 6.788(4.5); 3.930(2.0); 3.912(2.0); 3.313(61.7); 2.689(2.5); 2.670(4.4); 2.651(2.6); 2.524(1.61; 2.519(2.3); 2.511 (37.4); 2.506(82.7); 2.502(116.6); 2.497(81.5); 2.492(36.3); 2.461(0.6); 2.456(0.7); 2.452(0.7); 2.447(0.6); 2.333(0.6); 2.328(0.7); 2.324(0.5); 2.074(0.5); 1.760(0.7); 1.752(0.7); 1.743(0.9); 1.724(0.7); 1.694(0.8); 1.676(2.9); 1.657(4.7); 1.638(3.9); 1.619(2.3); 1.601(1.5); 1.591(1.4); 1.525(2.1); 1.496(2.0); 1.169(0.7); 1.132(2.9); 1.102(2.2); 1.073(1.6); 1.038(1.1); 1.016(7.8); 0.998(16.0); 0.980(6.7); 0.955(0.8); 0.936(1.4); 0.918(0.6); 0.000(14.4) Example I-027: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.005(3.5); 6.898(1.6); 5.129(4.5); 3.913(1.0); 3.895(1.0); 3.317(13.2); 2.670(0.6); 2.523(1.4); 2.518(2.0); 2.510(30.6); 2.505(67.7); 2.501(95.1); 2.496(66.6); 2.492(30.0); 2.455(0.6); 2.450(0.8); 2.446(0.6); 2.328(0.6); 2.142(16.0); 1.988(1.1); 1.657(0.7); 1.546(0.8); 1.515(0.8); 1.175(0.7); 1.157(0.6); 1.135(1.1); 1.060(0.6); 0.008(1.4); 0.000(63.5); 0.008(2.2) Example I-028: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.995(12.9); 6.849(8.0); 4.440(16.0); 4.289(0.8); 4.272(0.7); 3.924(4.7); 3.906(4.8); 3.345(75.2); 3.311(142.5); 3.261(0.9); 3.166(0.5); 2.675(0.9); 2.670(1.4); 2.666(0.9); 2.524(3.0); 2.519(4.4); 2.510(80.8); 2.506(181.0); 2.501(256.8); 2.496(180.0); 2.492(81.0); 2.460(1.3); 2.456(1.7); 2.451(1.9); 2.447(1.7); 2.405(0.6); 2.337(0.7); 2.332(1.3); 2.328(1.6); 2.323(1.3); 2.073(0.7); 1.830(0.8); 1.819(1.0); 1.810(1.2); 1.792(0.9); 1.653(2.9); 1.593(2.0); 1.532(2.8); 1.502(2.8); 1.138(4.5); 1.087(1.7); 1.055(2.2); 1.027(1.7); 0.954(1.0); 0.936(1.9); 0.918(0.8); 0.008(0.8); 0.000(31.2); 0.008(1.0) Example I-029: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.715(1.9); 7.262(69.6); 6.824(3.4); 6.822(6.5); 6.819(3.4); 5.299(5.7); 3.841(7.5); 3.823(7.5); 2.809(1.2); 2.792(3.6); 2.790(3.7); 2.774(3.8); 2.771(3.8); 2.755(1.3); 2.753(1.3); 2.631(0.7); 2.613(1.9); 2.595(1.9); 2.576(0.8); 1.884(0.5); 1.875(0.6); 1.865(0.7); 1.856(0.9); 1.847(0.7); 1.837(0.6); 1.828(0.6); 1.747(1.3); 1.741(1.3); 1.716(2.2); 1.709(2.8); 1.674(2.7); 1.288(7.1); 1.277(7.3); 1.269(16.0); 1.258(14.8); 1.251(8.0); 1.240(7.7); 1.205(2.9); 1.182(2.1); 1.152(0.5); 1.072(0.8); 1.043(1.7); 1.014(1.4); 0.008(0.7); 0.000(26.2); 0.008(0.7) Example I-030: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.621(1.6); 7.519(1.3); 7.260(237.6); 7.210(1.5); 7.158(2.1); 6.996(1.3); 6.868(6.6); 5.299(15.6); 3.850(7.1); 3.831(7.3); 3.804(2.3); 3.786(2.4); 2.765(1.4); 2.746(4.3); 2.728(4.5); 2.709(1.7); 2.660(0.6); 2.639(1.6); 2.637(1.6); 2.620(1.6); 2.601(0.7); 1.860(1.6); 1.851(1.5); 1.842(1.2); 1.832(1.2); 1.823(1.1); 1.814(0.9); 1.786(0.7); 1.742(2.9); 1.719(4.5); 1.687(5.5); 1.661(5.0); 1.600(4.0); 1.364(0.5); 1.346(1.1); 1.328(0.7); 1.292(7.2); 1.274(16.0); 1.254(14.1); 1.235(5.4); 1.224(2.8); 1.205(6.5); 1.186(5.4); 1.070(1.4); 1.040(2.8); 1.009(2.6); 0.987(1.8); 0.899(0.8); 0.882(1.8); 0.864(0.9); 0.069(2.9); 0.008(2.2); 0.000(89.2); 0.008(2.8); 0.050(0.7) Example I-031: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.410(1.2); 7.526(0.6); 7.267(107.2); 7.218(0.6); 7.003(0.6); 6.684(1.5); 5.301(4.1); 3.976(1.4); 3.961(1.4); 2.687(2.9); 2.668(3.4); 2.648(3.2); 2.586(1.0); 2.581(1.1); 2.576(0.9); 1.827(0.6); 1.818(0.8); 1.809(0.6); 1.799(0.5); 1.791(0.5); 1.720(2.1); 1.714(1.9); 1.701(2.9); 1.684(6.6); 1.663(5.6); 1.644(3.3); 1.627(2.3); 1.332(0.5); 1.301(6.6); 1.282(13.8); 1.263(6.7); 1.205(0.8); 1.182(2.9); 1.162(2.2); 1.139(1.2); 1.102(1.4); 1.074(1.1); 1.061(7.7); 1.042(16.0); 1.024(6.7); 0.008(1.1); 0.000(38.3); 0.008(1.1) Example I-032: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.848(1.5); 7.260(81.7); 7.210(0.6); 6.577(8.4); 3.986(2.1); 3.972(2.1); 2.698(3.4); 2.679(4.3); 2.659(3.6); 1.829(0.8); 1.821(0.9); 1.723(2.9); 1.705(3.2); 1.686(4.1); 1.666(5.4); 1.656(4.4); 1.648(4.7); 1.629(2.8); 1.562(4.6); 1.255(2.1); 1.186(3.9); 1.165(3.1); 1.144(1.8); 1.105(2.0); 1.073(8.7); 1.055(16.0); 1.036(7.1); 0.882(0.6); 0.008(1.4); 0.000(29.8); 0.008(1.2) Example I-033: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.077(0.9); 7.261(51.7); 7.211(0.6); 6.902(1.0); 5.299(2.0); 4.442(5.9); 4.055(1.8); 4.037(1.9); 3.392(16.0); 2.582(0.6); 1.716(1.2); 1.668(1.8); 1.649(1.6); 1.642(1.6); 1.308(3.4); 1.289(7.0); 1.271(3.5); 1.242(0.6); 1.210(0.7); 1.186(2.0); 1.164(1.6); 1.130(0.8); 1.099(1.0); 1.070(0.8); 0.000(18.9); 0.008(1.0) Example I-034: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.261(25.2); 6.804(3.6); 5.299(1.8); 4.446(4.6); 4.054(1.1); 4.036(1.1); 3.414(16.0); 1.715(0.9); 1.661(1.2); 1.630(0.9); 1.600(0.6); 1.186(1.4); 1.164(1.0); 1.098(0.6); 0.000(9.2) Example I-035: 1H-NMR(400.0 MHz, CDCl3): = 7.262(24.0); 6.873(3.2); 5.299(3.7); 5.122(5.4); 3.978(0.8); 3.960(0.8); 2.148(16.0); 1.727(0.7); 1.662(1.1); 1.632(0.8); 1.605(0.8); 1.255(0.5); 1.186(1.2); 1.164(0.9); 1.106(0.6); 0.000(8.8) Example I-036: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.013(11.7); 4.499(16.0); 4.318(1.0); 4.026(0.7); 3.955(5.2); 3.936(5.2); 2.671(0.8); 2.666(0.5); 2.524(1.5); 2.520(2.3); 2.511(49.3); 2.506(112.1); 2.502(161.1); 2.497(117.0); 2.493(56.7); 2.452(1.5); 2.333(0.8); 2.329(1.1); 2.324(0.8); 1.909(0.8); 1.808(0.8); 1.798(1.0); 1.789(1.2); 1.770(0.9); 1.651(2.8); 1.593(1.8); 1.533(2.8); 1.502(3.0); 1.235(1.0); 1.132(4.5); 1.079(1.8); 1.050(2.3); 1.025(1.8); 0.000(10.4) Example I-037: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.787(16.0); 6.785(16.0); 6.767(13.8); 4.158(9.9); 4.140(10.0); 3.618(0.9); 3.616(0.6); 3.612(0.5); 3.608(0.7); 3.601(2.2); 3.595(0.7); 3.585(1.0); 3.312(76.7); 3.262(0.5); 2.675(0.8); 2.670(1.1); 2.666(0.8); 2.534(0.5); 2.524(2.7); 2.519(3.9); 2.511(65.7); 2.506(145.5); 2.501(205.1); 2.497(143.1); 2.492(63.9); 2.456(1.1); 2.451(1.5); 2.447(1.1); 2.333(0.9); 2.328(1.3); 2.324(1.0); 2.074(4.4); 2.065(0.8); 2.052(1.6); 2.046(1.8); 2.031(3.2); 2.019(1.9); 2.012(1.8); 1.998(0.9); 1.915(1.0); 1.895(1.5); 1.887(1.7); 1.868(1.3); 1.776(1.0); 1.769(0.8); 1.760(2.8); 1.751(0.9); 1.743(1.0); 1.666(4.4); 1.584(5.2); 1.554(4.5); 1.320(0.7); 1.301(0.7); 1.149(6.6); 1.130(6.2); 1.086(3.4); 1.069(2.4); 1.064(3.6); 1.053(8.4); 1.048(8.3); 1.033(7.2); 1.028(7.8); 1.018(2.2); 0.955(1.8); 0.936(3.7); 0.918(1.4); 0.809(2.3); 0.799(6.3); 0.794(7.2); 0.786(6.6); 0.781(6.6); 0.770(2.0); 0.008(1.6); 0.000(62.3); 0.009(2.0) Example I-038: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.008(16.0); 6.860(11.0); 4.743(2.7); 4.736(5.0); 4.727(2.9); 4.708(4.6); 4.675(6.0); 4.493(6.1); 4.461(4.8); 3.978(5.4); 3.959(5.5); 3.814(1.1); 3.806(1.4); 3.794(1.2); 3.785(2.5); 3.777(1.8); 3.766(1.3); 3.757(1.4); 3.618(0.6); 3.601(0.9); 3.545(1.2); 3.533(2.1); 3.519(1.5); 3.504(1.8); 3.358(0.7); 3.309(75.9); 3.259(0.9); 2.675(0.5); 2.671 (0.8); 2.666(0.6); 2.551 (0.6); 2.524(2.0); 2.519(3.0); 2.511 (45.1); 2.506(98.5); 2.502(138.0); 2.497(97.8); 2.492(44.8); 2.457(0.8); 2.452(0.9); 2.448(0.6); 2.333(0.6); 2.328(0.8); 2.324(0.6); 2.073(0.9); 1.853(0.9); 1.842(1.2); 1.834(1.4); 1.815(1.1); 1.784(0.9); 1.776(1.1); 1.769(1.3); 1.760(2.4); 1.751(1.7); 1.743(1.6); 1.739(1.6); 1.726(1.1); 1.708(2.3); 1.701(1.8); 1.676(4.7); 1.669(4.4); 1.661(4.4); 1.655(4.3); 1.593(2.4); 1.542(5.6); 1.534(6.3); 1.519(6.3); 1.506(7.3); 1.492(5.1); 1.129(5.2); 1.107(3.3); 1.060(2.5); 1.032(1.9); 0.955(0.6); 0.937(1.2); 0.000(3.5) Example I-039: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 4.117(1.3); 4.100(1.6); 4.080(0.7); 4.013(0.6); 4.000(3.0); 3.979(1.8); 3.963(1.0); 3.872(1.0); 3.854(1.1); 3.839(1.2); 3.821(1.2); 2.869(1.5); 2.862(2.7); 2.856(3.4); 2.757(0.8); 2.740(0.8); 2.724(0.8); 2.707(0.8); 2.510(20.4); 2.505(50.8); 2.500(75.8); 2.496(57.3); 2.491(29.1); 2.455(1.2); 2.450(1.2); 2.446(1.0); 2.332(0.6); 2.327(0.8); 2.323(0.7); 2.238(0.6); 2.218(0.6); 2.214(1.0); 2.201(1.2); 2.195(3.0); 2.183(3.2); 2.176(3.3); 2.164(3.2); 2.158(1.4); 2.145(1.2); 2.141(0.7); 2.122(0.7); 2.040(1.6); 1.908(2.4); 1.723(0.8); 1.694(1.8); 1.678(1.8); 1.670(1.8); 1.660(1.6); 1.652(1.4); 1.626(2.0); 1.596(1.4); 1.298(1.0); 1.284(0.8); 1.236(1.7); 1.200(0.9); 1.168(1.8); 0.998(0.8); 0.972(1.1); 0.965(7.5); 0.954(0.9); 0.946(16.0); 0.928(7.1); 0.890(0.7); 0.863(0.6); 0.008(2.1); 0.000(51.5); 0.009(1.0) Example I-040: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 9.625(16.0); 8.705(0.5); 7.789(15.1); 7.184(7.6); 6.905(1.1); 5.468(1.4); 4.408(7.2); 4.390(7.1); 4.012(0.7); 3.993(0.6); 3.633(1.1); 3.615(1.1); 3.608(1.2); 3.591(1.2); 3.305(91.5); 3.256(0.5); 2.674(2.1); 2.669(3.1); 2.665(2.2); 2.660(1.0); 2.555(2.0); 2.551(1.8); 2.523(8.0); 2.518(11.4); 2.509(165.2); 2.505(359.0); 2.500(501.6); 2.496(355.1); 2.491(162.9); 2.460(3.0); 2.456(3.5); 2.451(3.3); 2.447(1.6); 2.385(0.6); 2.381(0.6); 2.332(2.1); 2.327(3.0); 2.322(2.1); 2.318(1.0); 2.072(0.8); 1.645(3.3); 1.626(3.0); 1.591(2.0); 1.572(1.9); 1.526(2.7); 1.493(2.8); 1.369(0.7); 1.355(2.7); 1.298(0.6); 1.259(1.1); 1.236(3.9); 1.207(2.9); 1.189(6.2); 1.172(3.6); 1.125(3.3); 1.105(5.0); 1.081(2.4); 1.043(1.5); 1.011(2.0); 0.986(1.7); 0.954(1.1); 0.919(1.0); 0.902(1.0); 0.879(1.0); 0.861(1.1); 0.854(0.8); 0.146(1.2); 0.050(1.4); 0.011(0.6); 0.010(0.9); 0.008(10.1); 0.006(3.3); 0.005(4.0); 0.000(384.5); 0.006(7.3); 0.008(12.6); 0.011(3.4); 0.013(2.5); 0.014(2.2); 0.014(2.0); 0.015(1.8); 0.016(1.8); 0.018(1.4); 0.022(1.2); 0.025(1.0); 0.026(1.1); 0.034(0.9); 0.049(2.5); 0.120(0.7); 0.150(1.3) Example I-041: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.189(5.3); 6.905(4.7); 5.468(4.5); 4.011(2.6); 3.993(2.7); 3.657(1.2); 3.650(1.1); 3.633(3.0); 3.625(1.5); 3.615(3.1); 3.608(3.2); 3.598(1.4); 3.590(3.1); 3.572(1.1); 3.566(1.3); 3.307(44.8); 2.670(0.8); 2.500(127.7); 2.496(101.7); 2.327(0.8); 1.839(0.6); 1.654(1.7); 1.592(1.1); 1.519(1.8); 1.492(1.5); 1.236(0.5); 1.207(7.8); 1.189(16.0); 1.172(8.0); 1.124(2.6); 1.102(2.9); 1.074(1.7); 1.044(1.0); 0.000(21.5) Example I-042: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.882(4.9); 5.752(8.7); 4.750(1.4); 4.729(0.8); 4.718(2.7); 4.540(1.6); 4.507(1.3); 4.019(1.8); 4.001(1.9); 3.759(0.7); 3.751(0.5); 3.503(0.6); 3.305(12.2); 2.583(1.6); 2.565(5.6); 2.547(5.8); 2.529(1.7); 2.524(0.7); 2.519(0.7); 2.510(8.4); 2.506(18.4); 2.501(25.8); 2.497(18.3); 2.492(8.3); 1.704(0.8); 1.680(1.3); 1.665(1.7); 1.603(0.7); 1.576(1.2); 1.548(1.2); 1.532(0.9); 1.508(1.4); 1.486(1.6); 1.262(0.5); 1.245(0.8); 1.168(0.6); 1.145(1.6); 1.124(1.4); 1.085(0.8); 1.055(0.6); 1.028(7.2); 1.010(16.0); 0.992(6.8); 0.858(0.6); 0.000(16.4) Example I-043: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 12.559(3.8); 6.769(16.0); 5.754(2.9); 4.767(9.1); 4.732(7.1); 4.588(6.9); 4.554(5.1); 4.015(0.6); 3.972(5.4); 3.960(5.5); 3.955(5.4); 3.920(0.8); 3.799(1.4); 3.791(1.9); 3.771(3.3); 3.764(2.5); 3.750(2.0); 3.744(2.0); 3.536(1.6); 3.525(3.0); 3.512(2.3); 3.496(2.6); 3.312(14.0); 2.671(0.8); 2.506(98.8); 2.502(136.2); 2.497(104.5); 2.329(0.9); 1.841(2.0); 1.822(1.7); 1.750(1.8); 1.726(2.7); 1.707(3.7); 1.677(6.8); 1.662(7.0); 1.597(3.7); 1.530(10.8); 1.235(4.6); 1.138(7.9); 1.117(6.4); 1.075(4.2); 1.044(3.1); 0.874(0.8); 0.858(2.1); 0.840(1.0); 0.008(1.7); 0.000(52.3); 0.008(3.1) Example I-044: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 10.596(2.9); 5.752(3.5); 3.909(1.2); 3.891(1.3); 3.876(1.3); 3.858(1.2); 3.717(0.5); 3.697(1.6); 3.684(1.3); 3.670(0.6); 3.431(1.3); 3.418(1.3); 3.404(1.7); 3.391(1.5); 3.228(1.7); 3.208(1.7); 3.201(1.6); 3.181(1.3); 2.984(1.0); 2.967(1.0); 2.940(1.7); 2.924(1.5); 2.822(2.3); 2.789(1.3); 2.779(1.7); 2.772(1.5); 2.756(1.2); 2.739(1.1); 2.523(0.8); 2.519(1.2); 2.510(16.4); 2.505(34.7); 2.501(47.8); 2.496(34.4); 2.492(16.2); 2.403(1.0); 2.399(1.1); 2.384(3.1); 2.380(3.1); 2.364(3.4); 2.362(3.2); 2.345(1.3); 2.041(0.8); 1.988(1.2); 1.908(1.9); 1.694(2.3); 1.687(2.3); 1.668(1.8); 1.657(1.8); 1.633(2.2); 1.606(1.7); 1.299(0.5); 1.236(1.7); 1.222(1.0); 1.212(1.0); 1.193(1.8); 1.175(2.5); 1.157(1.7); 1.120(0.7); 1.092(7.5); 1.073(16.0); 1.054(7.2); 1.041(0.6); 1.010(0.9); 0.982(0.7); 0.911(0.9); 0.881(0.7); 0.008(1.0); 0.000(28.4); 0.008(0.9) Example I-045: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 10.630(2.2); 5.752(2.5); 4.083(0.5); 4.069(1.4); 4.061(2.0); 4.054(2.9); 4.049(3.2); 4.030(1.3); 4.022(1.4); 4.011(0.9); 3.893(0.9); 3.875(0.9); 3.860(1.0); 3.841(1.0); 3.103(0.7); 3.086(0.8); 3.060(1.0); 3.042(1.0); 2.801(0.8); 2.784(1.0); 2.773(2.0); 2.751(0.9); 2.730(1.4); 2.524(0.5); 2.519(0.8); 2.510(12.0); 2.506(25.8); 2.501(35.8); 2.496(25.4); 2.492(11.8); 2.396(0.8); 2.390(0.7); 2.376(2.1); 2.371(2.1); 2.357(2.2); 2.352(2.2); 2.338(0.8); 2.333(0.9); 2.176(0.5); 2.157(0.6); 2.153(0.8); 2.137(1.3); 2.134(2.8); 2.118(3.0); 2.115(3.1); 2.100(2.9); 2.096(1.3); 2.081(0.9); 2.076(0.6); 2.058(0.5); 2.041(1.0); 1.908(1.2); 1.698(1.9); 1.688(1.9); 1.681(1.9); 1.664(1.2); 1.654(1.3); 1.632(1.5); 1.606(1.3); 1.299(0.5); 1.236(1.1); 1.217(0.7); 1.210(0.8); 1.178(1.5); 1.167(1.5); 1.090(6.1); 1.071(13.3); 1.052(6.0); 1.016(0.7); 0.989(0.6); 0.925(7.2); 0.906(16.0); 0.888(7.1); 0.008(0.7); 0.000(22.5); 0.008(0.7) Example I-046: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.998(6.3); 6.892(0.8); 5.145(8.3); 3.916(2.1); 3.898(2.1); 3.471(1.0); 2.524(0.9); 2.519(1.3); 2.510(26.5); 2.506(58.2); 2.501(81.8); 2.496(58.7); 2.492(27.5); 2.467(6.2); 2.457(0.6); 2.449(6.1); 2.430(2.0); 2.328(0.6); 1.988(1.1); 1.811(0.6); 1.802(0.7); 1.784(0.6); 1.659(1.6); 1.598(1.0); 1.545(1.6); 1.515(1.5); 1.235(1.9); 1.193(0.6); 1.175(1.0); 1.157(1.2); 1.135(2.5); 1.115(1.7); 1.090(8.0); 1.071(16.0); 1.052(7.5); 1.032(1.0); 0.008(0.7); 0.000(26.3); 0.008(0.8) Example I-047: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 12.529(3.8); 6.762(16.0); 5.777(2.7); 5.763(5.9); 5.755(12.0); 5.753(14.0); 4.558(11.3); 4.545(11.7); 3.961(9.2); 3.943(9.7); 3.311(18.3); 2.670(0.9); 2.524(2.1); 2.506(125.3); 2.501(164.6); 2.498(121.5); 2.497(121.0); 2.328(1.0); 1.988(0.7); 1.800(2.3); 1.782(1.9); 1.656(6.0); 1.596(4.0); 1.550(6.1); 1.521(6.0); 1.457(0.5); 1.406(0.6); 1.395(0.7); 1.299(0.6); 1.237(4.6); 1.193(1.0); 1.142(9.1); 1.122(6.4); 1.067(4.6); 1.038(3.6); 0.875(0.8); 0.858(2.2); 0.841(1.1); 0.008(1.0); 0.002(23.2); 0.000(32.7) Example I-048: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 10.786(3.4); 6.932(5.0); 5.706(0.8); 4.526(3.5); 3.967(2.8); 3.949(2.9); 3.508(0.7); 3.326(26.5); 3.116(0.8); 3.104(0.8); 3.098(0.9); 3.086(0.9); 2.674(1.5); 2.669(2.2); 2.665(1.5); 2.523(5.1); 2.518(8.5); 2.509(145.0); 2.505(311.3); 2.500(432.1); 2.496(310.3); 2.491(147.7); 2.472(8.8); 2.453(7.4); 2.435(2.8); 2.332(2.4); 2.327(3.1); 2.322(2.4); 2.072(0.8); 1.988(1.0); 1.798(0.8); 1.655(1.9); 1.597(1.2); 1.546(1.9); 1.514(1.9); 1.298(0.8); 1.258(1.4); 1.236(5.7); 1.194(2.2); 1.176(4.3); 1.158(3.0); 1.130(8.5); 1.111(16.0); 1.093(7.6); 1.063(1.4); 1.029(1.2); 1.009(1.0); 0.854(1.0); 0.836(0.6); 0.146(0.8); 0.008(7.3); 0.000(215.3); 0.008(6.7); 0.150(0.8) Example I-049: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.799(4.6); 4.540(5.8); 3.988(2.6); 3.970(2.8); 2.578(1.9); 2.560(6.3); 2.542(6.5); 2.523(3.0); 2.501(52.1); 2.498(40.1); 1.989(0.7); 1.825(0.6); 1.663(1.6); 1.601(1.0); 1.570(1.7); 1.540(1.6); 1.195(0.6); 1.176(1.7); 1.149(2.5); 1.130(2.0); 1.112(1.6); 1.074(1.3); 1.046(1.0); 1.028(7.8); 1.010(16.0); 0.992(7.7); 0.001(15.7); 0.000(16.7) Example I-050: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.786(5.6); 6.780(8.0); 3.912(1.6); 3.898(1.6); 3.307(50.7); 2.670(0.7); 2.561(2.8); 2.544(3.2); 2.523(2.3); 2.518(3.2); 2.510(38.2); 2.505(78.1); 2.501(105.2); 2.496(76.0); 2.492(37.4); 2.332(0.5); 2.328(0.6); 1.988(1.2); 1.911(0.8); 1.894(1.1); 1.878(0.8); 1.732(0.7); 1.714(0.6); 1.661(1.7); 1.652(1.7); 1.588(1.2); 1.520(1.8); 1.492(1.7); 1.175(1.0); 1.157(1.2); 1.129(2.6); 1.103(2.0); 1.072(1.6); 1.041(1.0); 0.960(16.0); 0.943(15.7); 0.000(6.8) Example I-052: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(2.9); 7.329(0.8); 7.324(4.6); 7.322(5.1); 7.318(2.5); 7.316(2.5); 7.310(5.2); 7.308(6.3); 7.305(4.3); 7.302(7.2); 7.299(6.7); 7.296(1.9); 7.294(2.9); 7.292(3.0); 7.292(3.1); 7.288(7.0); 7.286(6.1); 7.284(1.9); 7.283(1.5); 7.282(1.5); 7.281(1.7); 7.280(1.6); 7.280(1.6); 7.279(1.7); 7.278(1.6); 7.277(1.4); 7.276(1.2); 7.276(1.3); 7.275(1.5); 7.274(1.5); 7.273(1.5); 7.272(1.5); 7.272(1.6); 7.271(1.8); 7.270(2.0); 7.269(2.2); 7.268(2.4); 7.268(2.6); 7.267(3.1); 7.266(3.8); 7.265(4.5); 7.264(5.5); 7.264(7.3); 7.263(10.4); 7.260(500.4); 7.256(17.1); 7.255(13.4); 7.254(10.6); 7.253(8.5); 7.252(7.5); 7.252(6.8); 7.251(6.0); 7.250(5.5); 7.249(5.1); 7.248(4.8); 7.248(4.4); 7.247(4.2); 7.246(3.9); 7.245(3.6); 7.244(3.5); 7.244(3.5); 7.243(3.3); 7.242(3.0); 7.241(2.9); 7.240(2.8); 7.240(2.8); 7.239(2.7); 7.238(2.6); 7.237(2.6); 7.236(2.5); 7.236(2.3); 7.235(2.4); 7.234(2.5); 7.233(2.5); 7.232(2.2); 7.232(2.1); 7.231(1.6); 7.230(1.6); 7.229(1.9); 7.228(1.8); 7.227(1.8); 7.226(1.8); 7.224(1.5); 7.224(1.3); 7.222(1.4); 7.220(1.5); 7.217(0.7); 7.137(1.1); 7.130(8.5); 7.125(2.7); 7.114(3.0); 7.108(15.0); 7.104(3.2); 7.092(2.6); 7.087(6.9); 7.080(0.9); 6.996(2.9); 6.268(8.8); 4.710(3.0); 3.431(15.8); 3.413(16.0); 2.044(2.0); 1.564(4.9); 1.556(5.4); 1.532(7.8); 1.500(2.8); 1.284(0.6); 1.276(1.0); 1.259(2.5); 1.241(0.9); 1.177(0.6); 1.168(1.1); 1.159(1.4); 1.150(1.6); 1.140(2.1); 1.131(1.9); 1.122(1.6); 1.112(1.6); 1.104(1.1); 1.094(0.6); 1.086(0.5); 1.057(3.4); 1.024(4.9); 1.002(2.1); 0.994(2.7); 0.988(1.6); 0.970(4.1); 0.939(4.0); 0.908(3.1); 0.899(2.2); 0.882(1.9); 0.864(0.9); 0.726(1.5); 0.717(1.4); 0.695(3.4); 0.689(3.3); 0.665(3.2); 0.635(1.3); 0.146(0.5); 0.014(0.5); 0.012(0.6); 0.011(0.7); 0.010(0.8); 0.010(1.1); 0.008(6.0); 0.006(1.9); 0.006(2.0); 0.005(2.4); 0.004(3.0); 0.003(4.8); 0.002(8.1); 0.000(193.4); 0.003(13.7); 0.005(5.2); 0.006(4.2); 0.007(3.5); 0.008(6.8); 0.011(2.2); 0.011(2.0); 0.012(1.8); 0.013(1.7); 0.031(0.7); 0.150(0.6) Example I-053: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 8.05 (1H), 3.88 (2H), 1.88-1.50 (5H), 1.35 (18H), 1.19-0.92 (6H) Example I-054: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.860(16.0); 6.549(1.7); 5.754(8.5); 3.830(10.8); 3.812(11.1); 3.410(8.6); 2.670(1.0); 2.524(2.0); 2.510(57.3); 2.506(118.7); 2.502(161.7); 2.497(119.8); 2.493(61.4); 2.328(1.0); 1.808(1.0); 1.800(1.2); 1.790(1.4); 1.781(1.8); 1.772(1.7); 1.762(1.3); 1.753(1.2); 1.744(0.7); 1.677(2.9); 1.661(3.9); 1.609(2.3); 1.559(3.7); 1.535(8.2); 1.235(0.5); 1.174(2.0); 1.147(7.0); 1.127(4.6); 1.021(1.5); 0.992(3.2); 0.963(2.6); 0.000(3.5) Example I-056: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 12.377(1.6); 6.614(5.4); 5.754(3.3); 3.948(2.2); 3.932(2.2); 3.311(19.6); 2.621(3.0); 2.603(3.3); 2.524(1.0); 2.506(49.5); 2.502(67.9); 2.497(50.7); 2.493(26.0); 2.452(0.7); 1.882(0.9); 1.866(1.1); 1.849(1.0); 1.832(0.6); 1.752(0.8); 1.663(2.3); 1.655(2.3); 1.589(1.5); 1.534(2.2); 1.508(2.0); 1.236(1.2); 1.175(0.8); 1.157(1.6); 1.136(3.3); 1.115(3.7); 1.088(2.3); 1.058(1.2); 0.989(0.9); 0.972(1.1); 0.953(16.0); 0.936(15.8); 0.901(1.1); 0.884(0.9); 0.858(0.8); 0.000(10.2) Example I-057: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(2.5); 7.423(0.6); 7.405(1.6); 7.399(13.8); 7.394(4.6); 7.383(5.4); 7.378(19.8); 7.372(2.4); 7.304(0.6); 7.294(0.6); 7.287(1.3); 7.272(15.7); 7.268(7.9); 7.266(7.8); 7.266(7.9); 7.259(443.3); 7.252(12.6); 7.246(1.7); 7.209(1.4); 6.995(2.5); 6.244(11.5); 4.706(2.2); 3.436(16.0); 3.418(15.8); 2.043(1.8); 1.570(4.6); 1.562(4.4); 1.537(8.1); 1.502(2.6); 1.276(0.9); 1.258(2.2); 1.241(0.7); 1.178(0.7); 1.168(1.2); 1.159(1.5); 1.150(1.6); 1.140(2.2); 1.131(1.8); 1.122(1.6); 1.113(1.6); 1.103(1.0); 1.085(0.6); 1.064(3.6); 1.028(5.0); 1.005(1.8); 0.998(2.6); 0.990(1.4); 0.973(4.4); 0.942(4.2); 0.911(3.1); 0.882(1.8); 0.727(1.6); 0.719(1.5); 0.697(3.7); 0.668(3.3); 0.639(1.2); 0.146(0.6); 0.008(5.4); 0.000(167.8); 0.008(4.4); 0.150(0.5) Example I-058: .sup.1H-NMR(400.0 MHz, CDCl3): = 9.640(1.1); 7.261(6.6); 7.084(1.1); 4.528(0.6); 4.509(0.6); 1.544(0.6); 1.433(16.0); 1.420(0.7); 1.391(0.8); 0.000(2.6) Example I-059: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(3.0); 7.358(0.6); 7.310(3.2); 7.292(2.6); 7.288(4.1); 7.281(1.1); 7.271(5.5); 7.259(541.3); 7.253(6.2); 7.250(3.8); 7.246(1.0); 7.244(0.8); 7.242(0.6); 7.241(0.5); 7.237(0.6); 7.211(0.6); 6.995(3.1); 6.978(1.9); 6.972(2.3); 6.958(3.2); 6.952(4.5); 6.940(4.4); 6.933(3.4); 6.918(4.4); 6.910(3.2); 6.895(3.3); 6.888(2.5); 6.048(8.6); 4.722(3.1); 3.411(16.0); 3.393(16.0); 2.043(2.0); 1.576(4.8); 1.551(9.1); 1.526(3.7); 1.284(0.7); 1.276(1.1); 1.258(2.7); 1.241(0.9); 1.198(0.9); 1.190(1.2); 1.181(1.6); 1.171(1.7); 1.162(2.1); 1.153(1.8); 1.143(1.6); 1.134(1.5); 1.125(1.0); 1.116(0.7); 1.085(3.8); 1.048(4.8); 1.017(2.2); 1.010(3.4); 1.002(3.1); 0.990(3.3); 0.975(4.6); 0.945(2.7); 0.913(1.0); 0.882(1.5); 0.864(0.7); 0.747(1.6); 0.739(1.5); 0.718(3.8); 0.687(3.4); 0.659(1.2); 0.146(0.7); 0.050(0.5); 0.008(6.0); 0.000(204.7); 0.008(5.9); 0.149(0.6) Example I-060: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(1.2); 7.424(2.0); 7.420(3.5); 7.416(1.6); 7.408(2.4); 7.404(9.9); 7.400(6.4); 7.385(10.6); 7.362(4.4); 7.359(3.8); 7.345(5.7); 7.333(9.5); 7.330(10.5); 7.329(10.0); 7.314(6.2); 7.312(6.5); 7.260(197.8); 6.996(1.1); 6.348(11.6); 4.726(2.2); 3.444(15.8); 3.426(16.0); 2.043(1.0); 1.535(4.0); 1.528(3.7); 1.512(5.0); 1.504(5.3); 1.496(4.0); 1.284(0.5); 1.276(0.7); 1.258(1.9); 1.241(0.5); 1.170(0.6); 1.161(1.2); 1.151(1.4); 1.142(1.6); 1.133(2.2); 1.124(1.8); 1.114(1.6); 1.105(1.4); 1.096(0.9); 1.087(0.6); 1.006(4.2); 0.976(5.9); 0.951(4.7); 0.920(3.9); 0.890(3.0); 0.882(2.8); 0.864(1.1); 0.858(1.1); 0.693(1.6); 0.685(1.4); 0.663(3.7); 0.656(3.2); 0.633(3.4); 0.603(1.2); 0.008(2.3); 0.000(75.6); 0.008(2.5) Example I-061: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.80 (1H), 4.79- 4.72 (2H), 4.61-4.58 (1H), 4.00 (2H), 3.79-3.70 (1H), 3.53-3.47 (1H), 1.90-1.47 (7H), 1.36 (18H), 1.29-0.84 (9H) Example I-062: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.943(1.5); 7.518(3.0); 7.260(556.9); 7.227(0.8); 7.209(3.8); 6.996(3.1); 6.922(1.0); 6.782(1.5); 6.755(1.7); 6.739(1.8); 6.712(1.8); 5.846(3.5); 5.843(3.6); 5.804(3.2); 5.801(3.2); 5.523(2.9); 5.521(2.7); 5.496(2.7); 5.494(2.8); 5.298(10.2); 3.998(1.9); 3.979(2.0); 2.585(1.0); 2.375(0.9); 2.356(1.4); 2.337(1.0); 1.857(0.8); 1.838(0.9); 1.830(1.1); 1.821(1.0); 1.802(1.0); 1.715(2.9); 1.677(2.0); 1.657(3.7); 1.629(3.2); 1.540(3.4); 1.469(0.6); 1.452(0.5); 1.430(0.6); 1.333(1.7); 1.308(7.3); 1.289(14.8); 1.284(5.1); 1.270(8.6); 1.256(16.0); 1.239(3.4); 1.220(2.7); 1.208(3.1); 1.202(3.1); 1.190(4.2); 1.177(4.7); 1.153(4.0); 1.141(3.2); 1.134(4.1); 1.120(2.6); 1.115(3.1); 1.084(1.9); 1.011(0.7); 0.960(0.6); 0.954(0.6); 0.942(0.9); 0.920(0.9); 0.896(1.2); 0.880(3.2); 0.862(1.4); 0.256(1.1); 0.146(0.6); 0.069(13.0); 0.008(5.4); 0.000(217.0); 0.008(7.1); 0.033(0.6); 0.050(1.6); 0.150(0.8) Example I-063: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.430(0.7); 6.870(3.0); 6.856(3.7); 5.753(1.0); 4.220(2.3); 4.206(2.2); 4.039(0.6); 4.021(0.6); 3.920(1.7); 3.903(1.7); 3.307(27.2); 2.523(0.9); 2.518(1.4); 2.510(26.9); 2.505(59.0); 2.501(82.5); 2.496(58.8); 2.492(27.3); 2.328(0.5); 2.072(0.8); 1.988(2.4); 1.760(0.5); 1.658(1.6); 1.599(1.0); 1.541(1.4); 1.512(1.4); 1.444(0.6); 1.414(16.0); 1.236(1.4); 1.193(1.0); 1.175(1.8); 1.157(1.5); 1.130(2.2); 1.112(1.5); 1.085(1.1); 1.054(1.2); 1.030(0.9); 0.858(1.0); 0.008(0.7); 0.000(30.5); 0.008(1.1) Example I-064: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.519(1.8); 7.260(316.9); 7.228(0.6); 7.210(0.6); 7.084(26.8); 6.996(1.8); 5.434(0.7); 5.299(3.7); 3.860(0.8); 3.826(15.9); 3.807(16.0); 2.978(1.2); 2.903(1.0); 2.901(1.0); 1.894(0.6); 1.884(1.0); 1.875(1.3); 1.866(1.4); 1.856(1.8); 1.847(1.5); 1.838(1.2); 1.828(1.2); 1.819(0.7); 1.809(0.5); 1.761(2.3); 1.754(2.3); 1.729(3.5); 1.720(2.7); 1.702(3.8); 1.676(4.3); 1.672(4.2); 1.567(4.0); 1.554(1.7); 1.394(1.1); 1.284(0.7); 1.277(0.8); 1.254(2.0); 1.246(2.3); 1.215(4.3); 1.188(3.1); 1.157(0.9); 1.072( 1.4); 1.043(3.0); 1.013(2.4); 0.990(0.7); 0.982(0.8); 0.008(3.4); 0.000(119.8); 0.008(3.4) Example I-065: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.261(21.0); 6.327(3.7); 5.299(0.8); 4.438(2.2); 4.420(2.2); 3.170(12.9); 3.149(0.5); 2.637(1.4); 2.619(4.7); 2.601(4.8); 2.583(1.5); 1.704(0.6); 1.691(0.8); 1.632(16.0); 1.577(0.8); 1.551(2.6); 1.167(6.4); 1.149(13.4); 1.131(5.7); 1.119(0.6); 1.089(0.7); 0.000(8.0) Example I-066: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.260(45.4); 4.447(2.1); 4.429(2.1); 3.174(13.0); 1.668(16.0); 1.632(0.5); 1.565(0.7); 1.551(2.0); 1.309(2.3); 1.291(4.7); 1.272(2.3); 1.256(1.3); 1.155(0.9); 1.132(0.8); 1.077(0.6); 0.008(0.5); 0.000(17.9); 0.008(0.5) Example I-067: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.260(61.3); 6.776(0.7); 6.748(0.8); 6.747(0.8); 6.734(0.8); 6.732(0.8); 6.705(0.8); 6.390(3.3); 6.389(3.2); 5.796(1.5); 5.794(1.5); 5.754(1.4); 5.752(1.4); 5.552(1.6); 5.549(1.5); 5.524(1.4); 5.522(1.5); 3.992(0.8); 3.975(0.8); 2.640(1.6); 2.622(5.2); 2.604(5.4); 2.585(1.7); 1.742(0.6); 1.734(0.7); 1.721(0.7); 1.671(1.2); 1.644(0.9); 1.536(1.9); 1.189(1.3); 1.169(1.0); 1.159(7.6); 1.141(16.0); 1.123(7.3); 0.008(0.7); 0.000(23.4); 0.008(0.7) Example I-068: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 8.00 (1H), 3.88 (2H), 1.88-1.50 (5H), 1.35 (18H), 1.25-0.87 (6H) Example I-069: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.970(1.2); 6.605(0.7); 3.852(0.6); 3.834(0.6); 3.309(6.7); 2.510(4.8); 2.506(10.4); 2.501(14.6); 2.497(10.4); 2.492(4.8); 0.258(16.0); 0.249(0.5); 0.000(6.5) Example I-070: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.946(16.0); 6.584(10.6); 4.620(16.0); 3.858(10.1); 3.840(10.3); 3.308(64.4); 2.675(1.0); 2.670(1.4); 2.666(1.0); 2.524(4.4); 2.519(6.4); 2.510(82.6); 2.506(176.8); 2.501(243.7); 2.496(171.6); 2.492(77.4); 2.332(1.1); 2.328(1.5); 2.323(1.0); 1.988(1.6); 1.812(0.9); 1.803(1.0); 1.793(1.2); 1.785(1.6); 1.776(1.3); 1.766(1.1); 1.757(1.0); 1.677(2.5); 1.660(3.2); 1.610(2.0); 1.553(3.0); 1.521(3.2); 1.235(2.0); 1.226(0.8); 1.208(0.6); 1.193(0.8); 1.175(2.5); 1.146(5.9); 1.126(3.8); 1.025(1.2); 0.995(2.7); 0.966(2.2); 0.936(0.7); 0.008(3.5); 0.000(114.8); 0.008(3.4) Example I-071: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.689(1.6); 7.671(1.8); 7.658(1.5); 7.640(1.8); 7.569(1.1); 7.550(1.1); 7.514(7.1); 7.500(8.4); 7.492(8.2); 7.484(4.2); 7.479(7.0); 7.426(16.0); 7.370(7.4); 7.364(2.3); 7.348(12.1); 7.331(2.5); 7.325(5.2); 5.452(10.3); 4.038(0.7); 4.021(0.6); 3.880(8.8); 3.861(8.7); 3.308(210.5); 3.257(0.7); 2.674(3.2); 2.670(3.9); 2.665(2.9); 2.523(18.6); 2.509(275.1); 2.505(530.3); 2.500(677.5); 2.496(467.3); 2.491(207.5); 2.449(1.7); 2.445(2.2); 2.332(3.2); 2.327(4.0); 2.323(2.9); 1.988(2.8); 1.819(1.5); 1.666(3.6); 1.610(5.4); 1.576(4.0); 1.237(3.0); 1.192(2.0); 1.175(3.3); 1.157(6.2); 1.132(4.2); 1.045(1.5); 1.016(3.0); 0.986(2.5); 0.875(1.3); 0.858(3.9); 0.841(1.4); 0.146(0.7); 0.008(9.1); 0.000(209.0); 0.008(7.0); 0.051(0.7); 0.150(0.7) Example I-072: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.791(1.2); 7.140(16.0); 6.859(12.0); 5.586(6.2); 5.572(6.2); 4.855(2.5); 4.840(3.2); 4.827(2.4); 4.184(1.8); 4.165(2.1); 4.148(1.8); 3.842(1.5); 3.310(147.3); 2.670(2.7); 2.523(8.4); 2.510(160.1); 2.505(340.4); 2.501(467.5); 2.496(329.2); 2.492(148.4); 2.328(2.6); 1.742(1.6); 1.663(4.4); 1.594(2.9); 1.507(2.6); 1.480(2.4); 1.425(14.7); 1.410(14.3); 1.361(2.6); 1.235(5.6); 1.129(6.5); 1.067(3.5); 1.041(2.6); 0.008(7.4); 0.000(228.9); 0.008(6.9) Example I-073: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(0.8); 7.259(139.7); 7.236(1.5); 7.220(0.5); 7.216(1.8); 6.995(0.8); 6.980(1.2); 6.960(1.1); 6.268(1.2); 4.766(1.8); 4.737(0.6); 2.170(1.5); 1.532(16.0); 1.256(0.9); 0.008(1.6); 0.000(51.8); 0.008(1.6) Example I-074: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(4.7); 7.477(0.9); 7.459(3.0); 7.453(1.1); 7.443(1.4); 7.440(2.6); 7.436(1.4); 7.402(3.4); 7.383(5.3); 7.365(2.6); 7.362(1.6); 7.358(0.6); 7.311(0.8); 7.293(1.0); 7.290(1.6); 7.259(834.4); 7.227(0.6); 7.211(0.7); 7.175(4.4); 7.158(4.6); 7.154(3.1); 7.048(0.9); 7.029(0.7); 6.995(4.6); 6.869(0.7); 6.847(1.0); 6.825(0.9); 6.804(0.7); 6.787(1.0); 6.770(1.1); 6.762(1.7); 6.746(1.7); 6.738(1.0); 6.722(1.0); 6.394(8.7); 6.358(1.0); 5.199(7.2); 4.777(2.5); 2.170(0.5); 2.044(0.7); 1.536(16.0); 1.284(0.7); 1.255(2.8); 0.146(1.0); 0.008(9.5); 0.000(309.3); 0.008(9.0); 0.150(1.1) Example I-075: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(1.6); 7.260(272.2); 7.036(1.3); 7.015(2.9); 6.999(3.0); 6.996(3.4); 6.980(1.7); 6.882(0.9); 6.861(0.8); 6.814(1.5); 6.808(2.0); 6.794(2.6); 6.788(3.7); 6.779(3.0); 6.774(2.5); 6.767(2.1); 6.757(3.8); 6.750(2.8); 6.746(2.5); 6.734(2.9); 6.729(2.9); 6.722(3.8); 6.706(3.6); 6.698(2.1); 6.682(2.0); 6.591(1.4); 6.570(1.8); 6.565(1.7); 6.547(1.8); 6.526(1.4); 6.061(7.0); 4.778(16.0); 4.764(4.3); 4.163(1.8); 3.296(0.5); 2.170(2.3); 2.043(0.8); 1.547(1.6); 1.284(0.8); 1.276(0.8); 1.256(4.8); 1.240(0.5); 1.102(0.7); 0.880(1.0); 0.008(3.2); 0.000(101.4); 0.008(3.1) Example I-076: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(4.0); 7.292(1.2); 7.290(1.1); 7.285(1.2); 7.259(708.1); 7.209(0.7); 7.028(3.6); 7.014(4.7); 7.008(7.4); 6.995(9.4); 6.975(1.6); 6.968(9.8); 6.962(2.6); 6.947(12.8); 6.942(2.7); 6.930(1.8); 6.925(4.7); 6.740(2.1); 6.724(2.3); 6.716(3.6); 6.700(3.5); 6.692(2.2); 6.676(2.0); 6.554(1.4); 6.534(1.8); 6.512(1.8); 6.490(1.5); 6.290(8.1); 4.761(16.0); 4.738(4.0); 2.170(0.9); 1.534(11.4); 1.333(0.7); 1.284(1.2); 1.255(7.8); 0.880(0.8); 0.146(0.9); 0.008(7.6); 0.000(257.0); 0.008(8.0); 0.150(0.9) Example I-077: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 12.284(2.8); 8.033(16.0); 3.880(9.7); 3.862(9.9); 3.309(34.4); 2.674(0.8); 2.670(1.2); 2.665(0.8); 2.523(3.1); 2.519(4.2); 2.510(62.9); 2.505(136.8); 2.501(192.1); 2.496(136.9); 2.492(62.9); 2.332(0.8); 2.328(1.2); 2.323(0.8); 1.834(0.9); 1.826(1.1); 1.816(1.3); 1.807(1.6); 1.798(1.4); 1.788(1.2); 1.780(1.0); 1.666(3.5); 1.612(2.2); 1.581(3.7); 1.552(3.4); 1.236(1.4); 1.182(1.9); 1.154(6.2); 1.134(4.0); 1.112(1.0); 1.040(1.4); 1.011(2.9); 0.982(2.3); 0.875(0.6); 0.858(1.9); 0.841(0.7); 0.008(2.6); 0.000(86.8); 0.008(2.5) Example I-078: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 10.349(3.2); 7.938(9.1); 3.870(4.6); 3.851(4.6); 3.308(47.4); 2.674(0.5); 2.670(0.7); 2.523(2.1); 2.518(3.0); 2.510(39.6); 2.505(85.3); 2.500(118.6); 2.496(83.3); 2.491(37.9); 2.426(1.9); 2.408(6.3); 2.389(6.5); 2.370(2.0); 2.332(0.5); 2.327(0.7); 2.323(0.5); 1.988(0.9); 1.812(0.5); 1.802(0.6); 1.793(0.8); 1.784(0.6); 1.775(0.5); 1.680(1.2); 1.664(1.6); 1.610(1.0); 1.572(1.6); 1.540(1.6); 1.248(1.4); 1.192(0.6); 1.175(1.2); 1.153(2.8); 1.132(1.9); 1.118(7.6); 1.099(16.0); 1.080(6.9); 1.036(0.6); 1.007(1.4); 0.978(1.1); 0.875(0.7); 0.858(2.5); 0.841(0.9); 0.008(1.7); 0.000(55.1); 0.008(1.6) Example I-079: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(0.7); 7.291(6.0); 7.260(120.3); 6.996(0.7); 3.849(3.4); 3.831(3.4); 2.707(1.2); 2.689(1.2); 2.680(0.6); 2.662(2.0); 2.644(2.0); 2.626(0.6); 2.539(1.6); 2.521(1.7); 2.503(0.6); 2.494(1.0); 2.476(1.0); 1.775(0.6); 1.744(1.0); 1.736(1.1); 1.701(1.2); 1.534(13.2); 1.256(2.0); 1.228(1.1); 1.208(0.8); 1.158(7.4); 1.140(16.0); 1.122(7.1); 1.058(0.8); 1.028(0.6); 0.008(1.3); 0.000(45.0); 0.008(1.3) Example I-080: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.552(16.0); 7.210(4.1); 7.182(4.6); 7.168(4.6); 7.141(3.9); 6.273(14.8); 5.576(7.5); 5.573(7.7); 5.534(7.2); 5.530(6.7); 5.309(8.1); 5.305(7.4); 5.282(7.0); 5.278(7.9); 3.876(14.4); 3.858(15.1); 3.307(210.1); 2.670(4.9); 2.523(13.9); 2.510(264.9); 2.505(567.0); 2.500(785.9); 2.496(553.7); 2.491(251.6); 2.327(4.4); 1.808(2.9); 1.666(5.3); 1.610(3.5); 1.571(5.1); 1.536(5.0); 1.155(9.2); 1.135(5.8); 1.016(4.0); 0.991(3.6); 0.008(9.0); 0.000(287.4); 0.008(8.8) Example I-081: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 12.361(3.2); 7.964(16.0); 3.872(9.8); 3.853(10.0); 3.338(0.6); 3.309(159.7); 2.679(0.7); 2.674(1.7); 2.670(2.4); 2.665(1.6); 2.660(0.7); 2.532(1.5); 2.523(7.0); 2.518(9.8); 2.510(139.2); 2.505(302.8); 2.500(423.1); 2.496(298.7); 2.491(136.8); 2.477(1.8); 2.472(1.2); 2.467(1.0); 2.457(1.1); 2.332(1.9); 2.327(2.6); 2.323(2.0); 2.318(0.9); 2.072(0.8); 1.838(0.9); 1.829(1.2); 1.820(1.3); 1.811(1.6); 1.802(1.4); 1.792(1.1); 1.783(1.0); 1.667(3.5); 1.613(2.2); 1.585(3.8); 1.554(3.4); 1.236(4.8); 1.181(1.8); 1.154(6.1); 1.134(4.1); 1.041(1.4); 1.010(2.9); 0.981(2.3); 0.854(0.6); 0.146(0.7); 0.008(6.4); 0.000(212.9); 0.008(6.0); 0.150(0.8) Example I-082: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(0.6); 7.260(108.8); 7.172(6.0); 6.996(0.6); 3.845(3.1); 3.826(3.1); 2.711(1.2); 2.692(1.3); 2.684(0.6); 2.666(2.0); 2.648(2.0); 2.630(0.6); 2.541(1.7); 2.523(1.7); 2.505(0.6); 2.496(1.0); 2.478(1.0); 1.774(0.5); 1.736(1.0); 1.700(1.1); 1.532(8.3); 1.256(1.2); 1.226(1.0); 1.207(0.7); 1.157(7.2); 1.139(16.0); 1.121(7.0); 1.057(0.7); 1.028(0.6); 0.008(1.1); 0.000(40.3); 0.008(1.2) Example I-083: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 10.418(3.3); 7.865(8.5); 3.862(4.7); 3.844(4.8); 3.309(21.0); 2.524(0.8); 2.519(1.2); 2.510(18.3); 2.506(39.8); 2.501(55.7); 2.496(39.8); 2.492(18.4); 2.409(2.0); 2.390(6.6); 2.372(6.8); 2.353(2.1); 1.988(1.5); 1.818(0.5); 1.808(0.6); 1.800(0.8); 1.791(0.6); 1.781(0.5); 1.772(0.5); 1.680(1.2); 1.666(1.6); 1.612(1.0); 1.574(1.7); 1.542(1.6); 1.258(0.7); 1.247(2.0); 1.193(0.8); 1.175(1.6); 1.157(3.0); 1.154(2.9); 1.134(1.9); 1.112(7.7); 1.094(16.0); 1.075(7.0); 1.038(0.6); 1.008(1.4); 0.988(1.0); 0.979(1.1); 0.875(1.0); 0.858(3.4); 0.840(1.3); 0.008(0.7); 0.000(22.6); 0.009(0.7) Example I-084: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 10.472(1.6); 7.869(5.5); 3.860(2.9); 3.842(2.9); 3.308(24.3); 2.523(0.6); 2.519(0.9); 2.510(13.5); 2.505(29.4); 2.501(41.2); 2.496(29.3); 2.492(13.4); 2.077(16.0); 1.988(1.3); 1.680(0.7); 1.664(1.0); 1.610(0.6); 1.576(1.0); 1.545(0.9); 1.248(0.8); 1.193(0.6); 1.175(1.1); 1.157(1.9); 1.153(1.8); 1.134(1.1); 1.009(0.8); 0.979(0.6); 0.858(1.4); 0.000(14.0) Example I-085: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.261(40.0); 7.164(5.1); 4.138(4.4); 4.131(0.8); 3.846(2.8); 3.827(2.8); 3.550(16.0); 2.043(2.2); 1.736(0.7); 1.702(0.9); 1.675(0.8); 1.548(8.1); 1.276(0.9); 1.259(1.8); 1.241(0.8); 1.217(0.8); 1.194(0.6); 1.050(0.6); 0.882(1.3); 0.000(14.1) Example I-086: .sup.1H-NMR(400.0 MHz, CDCl3): = 9.441(2.1); 7.261(93.8); 7.222(1.5); 7.213(18.2); 6.997(0.5); 3.860(13.1); 3.842(13.2); 2.043(2.1); 1.894(0.7); 1.885(1.2); 1.875(1.4); 1.866(1.5); 1.856(1.9); 1.848(1.6); 1.838(1.3); 1.828(1.2); 1.820(0.7); 1.771(2.8); 1.741(4.2); 1.700(5.9); 1.673(4.8); 1.552(6.3); 1.323(1.0); 1.304(2.3); 1.265(11.5); 1.219(5.5); 1.195(3.9); 1.164(1.0); 1.082(1.6); 1.054(3.4); 1.023(2.7); 1.000(0.8); 0.993(0.8); 0.899(5.4); 0.882(16.0); 0.864(6.7); 0.008(1.3); 0.000(33.9); 0.008(1.1) Example I-087: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 10.366(2.9); 7.965(7.2); 5.753(16.0); 4.101(13.3); 3.930(3.0); 3.872(3.5); 3.854(3.6); 3.433(31.7); 3.311(8.4); 3.291(5.4); 2.524(0.6); 2.519(0.8); 2.511(12.0); 2.506(26.3); 2.502(36.8); 2.497(25.7); 2.492(11.4); 1.989(1.4); 1.909(1.7); 1.797(0.6); 1.680(0.9); 1.664(1.2); 1.609(0.7); 1.573(1.2); 1.540(1.2); 1.235(0.6); 1.193(0.7); 1.175(1.4); 1.157(2.2); 1.153(2.2); 1.132(1.4); 1.009(1.0); 0.980(0.8); 0.000(11.2) Example I-088: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 12.233(2.1); 8.030(16.0); 3.878(7.8); 3.860(8.1); 3.309(82.4); 2.670(1.3); 2.523(4.3); 2.518(5.8); 2.510(82.0); 2.505(179.1); 2.501(251.2); 2.496(176.0); 2.492(78.1); 2.327(1.4); 1.988(1.9); 1.806(1.4); 1.666(2.8); 1.582(3.2); 1.554(2.9); 1.282(1.4); 1.248(4.8); 1.175(2.4); 1.157(5.0); 1.135(3.3); 1.013(2.4); 0.984(2.1); 0.875(2.5); 0.858(8.6); 0.841(2.9); 0.008(1.9); 0.000(65.2); 0.009(2.0) Example I-089: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 8.150(3.8); 7.649(4.9); 7.623(4.0); 5.957(16.0); 3.517(10.1); 3.498(10.2); 3.363(4.5); 3.346(1.9); 3.312(445.4); 3.263(3.2); 2.674(3.4); 2.670(4.7); 2.665(3.4); 2.556(5.1); 2.552(4.6); 2.547(1.8); 2.534(1.0); 2.523(11.0); 2.518(17.5); 2.510(255.6); 2.505(551.8); 2.501(770.4); 2.496(555.0); 2.492(261.4); 2.461(4.6); 2.456(5.6); 2.452(4.9); 2.447(1.5); 2.417(0.8); 2.400(0.9); 2.332(3.2); 2.328(4.6); 2.323(3.4); 2.222(0.8); 2.213(0.7); 2.178(0.7); 2.166(0.5); 2.124(0.8); 2.072(0.8); 1.860(3.6); 1.669(5.4); 1.620(6.6); 1.594(6.4); 1.298(3.2); 1.259(5.1); 1.235(14.4); 1.191(3.9); 1.162(8.7); 1.140(6.8); 1.012(2.4); 0.982(4.2); 0.953(3.6); 0.929(2.2); 0.854(3.0); 0.836(1.7); 0.000(19.1) Example I-090: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.785(3.8); 6.569(2.5); 3.844(2.1); 3.826(2.2); 3.308(15.2); 2.928(0.9); 2.911(1.2); 2.894(0.9); 2.524(0.7); 2.519(1.1); 2.511(14.6); 2.506(31.4); 2.502(43.7); 2.497(30.6); 2.492(13.7); 1.656(0.8); 1.544(0.7); 1.516(0.7); 1.246(16.0); 1.229(15.5); 1.144(1.4); 1.123(0.9); 0.990(0.7); 0.960(0.5); 0.008(0.7); 0.000(24.2); 0.008(0.7) Example I-091: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.084(1.9); 7.548(1.1); 7.542(9.4); 7.537(3.1); 7.526(3.4); 7.521(12.0); 7.514(1.4); 7.484(1.2); 7.468(0.5); 7.463(1.6); 7.370(1.9); 7.365(0.6); 7.356(1.7); 7.350(13.0); 7.345(3.7); 7.334(3.2); 7.329(9.7); 7.322(1.2); 7.260(176.8); 7.016(16.0); 6.996(1.1); 6.898(1.9); 5.298(1.8); 4.415(0.6); 3.903(9.0); 3.885(9.1); 3.876(1.4); 3.858(1.2); 2.043(1.0); 1.924(0.7); 1.916(0.8); 1.905(0.9); 1.896(1.1); 1.888(1.0); 1.878(0.8); 1.869(0.7); 1.766(1.9); 1.734(5.4); 1.702(4.1); 1.545(7.6); 1.284(0.9); 1.276(1.0); 1.258(3.3); 1.255(3.3); 1.241(1.2); 1.222(3.0); 1.202(2.9); 1.158(0.7); 1.088(1.1); 1.060(2.2); 1.031 (1.9); 1.006(0.6); 0.999(0.7); 0.882(1.3); 0.864(0.6); 0.008(1.9); 0.000(64.2); 0.008(1.9) Example I-092: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.374(3.8); 7.369(1.2); 7.358(1.3); 7.353(4.5); 7.347(0.5); 7.270(0.5); 7.269(0.6); 7.268(0.8); 7.260(71.9); 7.255(0.8); 7.254(0.6); 7.104(0.6); 7.098(4.4); 7.092(1.3); 7.081(1.2); 7.076(3.7); 6.955(5.9); 5.298(1.0); 3.886(3.1); 3.868(3.2); 2.295(0.9); 2.277(1.0); 2.268(0.7); 2.250(2.2); 2.232(2.2); 2.216(1.0); 2.198(2.6); 2.180(2.7); 2.161(0.8); 2.152(1.1); 2.134(1.1); 1.743(1.6); 1.710(1.0); 1.537(6.4); 1.259(0.9); 1.227(0.8); 1.210(0.8); 1.194(0.6); 1.057(0.7); 1.034(0.6); 1.026(0.6); 0.991(7.1); 0.973(16.0); 0.955(6.7); 0.008(0.9); 0.000(27.7); 0.008(0.8) Example I-093: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.519(0.9); 7.495(4.1); 7.490(1.4); 7.479(1.6); 7.474(5.5); 7.467(0.7); 7.352(0.7); 7.345(6.0); 7.340(1.8); 7.329(1.5); 7.324(4.3); 7.318(0.5); 7.260(158.8); 7.182(0.8); 6.996(0.9); 6.961(7.7); 3.889(4.2); 3.871(4.2); 2.142(0.5); 1.892(0.5); 1.730(2.2); 1.698(1.4); 1.537(16.0); 1.264(1.4); 1.214(1.2); 1.199(1.0); 1.187(0.9); 1.054(0.9); 1.033(0.8); 0.973(2.7); 0.954(5.4); 0.936(2.6); 0.899(0.7); 0.882(2.5); 0.864(1.0); 0.008(1.8); 0.000(59.3); 0.008(1.6) Example I-094: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.182(6.5); 6.262(6.5); 5.755(9.1); 3.812(6.1); 3.794(6.1); 3.314(4.4); 2.823(1.3); 2.805(4.1); 2.786(4.2); 2.767(1.6); 2.526(0.7); 2.522(1.0); 2.513(11.8); 2.508(25.1); 2.504(34.7); 2.499(24.4); 2.495(11.1); 1.912(0.6); 1.810(0.6); 1.801(0.7); 1.792(0.8); 1.783(1.0); 1.774(0.8); 1.764(0.7); 1.755(0.6); 1.675(1.7); 1.659(2.0); 1.606(1.3); 1.596(1.2); 1.560(2.0); 1.529(2.0); 1.234(1.2); 1.195(6.9); 1.176(16.0); 1.158(7.8); 1.149(4.1); 1.128(2.4); 1.032(0.8); 1.003(1.6); 0.974(1.3); 0.000(2.3) Example I-095: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.519(0.7); 7.260(111.7); 7.212(7.5); 6.996(0.6); 5.530(2.1); 3.832(6.0); 3.814(6.1); 2.466(3.5); 2.448(7.5); 2.431(3.9); 2.043(0.7); 1.886(0.6); 1.876(0.6); 1.867(0.8); 1.858(0.7); 1.848(0.6); 1.839(0.5); 1.752(1.2); 1.746(1.2); 1.721(2.0); 1.712(2.6); 1.693(4.1); 1.675(7.2); 1.657(6.3); 1.639(3.0); 1.621(0.8); 1.561(1.3); 1.276(0.7); 1.264(0.9); 1.259(1.2); 1.241(1.1); 1.206(2.3); 1.182(1.8); 1.083(7.8); 1.065(16.0); 1.046(8.0); 1.009(1.4); 0.986(0.6); 0.882(1.0); 0.008(1.3); 0.000(41.0); 0.008(1.6) Example I-096: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 8.651(9.7); 7.897(3.7); 7.878(4.0); 7.530(16.0); 7.519(3.6); 7.500(3.2); 5.482(11.2); 3.895(8.7); 3.877(8.2); 3.311(104.5); 2.671(2.3); 2.505(324.3); 2.501(411.1); 2.497(301.4); 2.328(2.6); 1.988(4.8); 1.669(4.7); 1.609(6.2); 1.584(4.9); 1.175(4.3); 1.156(7.8); 1.023(3.6); 0.992(3.3); 0.000(45.0) Example I-097: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(0.7); 7.418(0.5); 7.413(0.8); 7.403(3.4); 7.401(3.5); 7.395(1.6); 7.385(2.2); 7.376(0.5); 7.372(0.7); 7.363(0.5); 7.259(113.4); 7.163(2.2); 7.159(2.5); 7.154(1.1); 7.144(1.5); 7.139(2.0); 6.995(0.7); 6.978(5.7); 5.298(0.8); 3.890(3.5); 3.872(3.5); 2.287(1.1); 2.269(1.1); 2.260(0.6); 2.242(1.9); 2.224(2.0); 2.206(0.6); 2.154(0.6); 2.136(2.3); 2.118(2.4); 2.099(0.8); 2.090(1.3); 2.072(1.3); 1.754(1.6); 1.735(1.8); 1.699(0.6); 1.532(12.5); 1.256(1.0); 1.228(1.0); 1.207(1.0); 1.060(0.8); 1.034(0.7); 0.970(7.2); 0.952(16.0); 0.934(6.9); 0.008(1.3); 0.000(42.4); 0.008(1.3) Example I-098: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.560(1.6); 7.556(1.2); 7.549(5.5); 7.545(6.0); 7.537(10.0); 7.532(11.2); 7.526(1.7); 7.521(1.2); 7.519(1.2); 7.428(1.3); 7.422(6.0); 7.414(4.3); 7.412(4.5); 7.404(5.2); 7.399(4.2); 7.260(148.0); 7.221(2.0); 6.996(1.2); 6.986(16.0); 3.894(9.6); 3.876(9.7); 2.401(0.6); 2.382(0.6); 2.076(1.0); 2.043(2.5); 1.935(0.8); 1.926(0.9); 1.916(1.0); 1.907(1.3); 1.898(1.1); 1.888(0.9); 1.879(0.8); 1.737(4.5); 1.730(4.1); 1.718(3.1); 1.672(1.1); 1.545(5.2); 1.304(0.8); 1.284(1.5); 1.276(2.2); 1.264(4.2); 1.259(4.2); 1.241(1.5); 1.221(2.6); 1.201(2.5); 1.188(2.4); 1.169(1.6); 1.156(0.8); 1.150(1.0); 1.086(1.0); 1.057(2.1); 1.034(1.8); 1.027(1.8); 0.997(0.7); 0.952(5.5); 0.933(10.6); 0.915(5.2); 0.899(2.2); 0.882(6.3); 0.864(2.5); 0.008(2.0); 0.000(57.1); 0.008(1.8) Example I-099: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.554(1.4); 7.547(1.9); 7.543(1.1); 7.532(6.4); 7.528(3.3); 7.525(2.8); 7.518(4.1); 7.514(9.7); 7.510(6.2); 7.506(4.2); 7.502(1.6); 7.495(3.4); 7.480(0.9); 7.475(1.2); 7.467(8.7); 7.462(7.4); 7.457(2.1); 7.452(2.6); 7.447(5.8); 7.444(4.4); 7.433(16.0); 5.449(5.8); 3.890(7.5); 3.872(7.5); 3.601 (0.5); 3.316(40.7); 2.674(0.8); 2.670(1.2); 2.665(0.8); 2.523(3.9); 2.518(5.8); 2.510(67.7); 2.505(144.8); 2.501 (199.8); 2.496(139.1); 2.492(62.5); 2.455(0.5); 2.450(0.6); 2.446(0.5); 2.332(0.9); 2.328(1.2); 2.323(0.8); 2.073(1.2); 1.852(0.7); 1.844(0.8); 1.833(0.9); 1.825(1.1); 1.816(1.0); 1.806(0.8); 1.797(0.7); 1.760(0.7); 1.684(1.9); 1.668(2.6); 1.662(2.6); 1.611(3.9); 1.583(3.0); 1.184(1.3); 1.155(4.2); 1.133(3.0); 1.109(0.6); 1.050(1.1); 1.020(2.2); 0.990(1.8); 0.968(0.6); 0.008(3.2); 0.000(107.7); 0.009(3.2) Example I-100: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.652(0.7); 7.582(9.9); 7.577(3.6); 7.566(4.2); 7.561(16.0); 7.482(15.6); 7.477(4.1); 7.466(3.8); 7.461(10.0); 7.454(1.6); 7.444(15.3); 5.481(8.7); 4.038(1.4); 4.021(1.4); 3.882(7.3); 3.864(7.4); 3.309(54.3); 2.670(1.4); 2.523(4.4); 2.518(6.4); 2.510(86.0); 2.505(185.0); 2.501(257.5); 2.496(181.0); 2.491(81.5); 2.327(1.4); 2.072(3.2); 1.988(6.4); 1.818(1.2); 1.662(2.8); 1.606(4.0); 1.571(3.0); 1.235(1.1); 1.193(2.4); 1.175(4.6); 1.157(5.4); 1.132(3.2); 1.016(2.4); 0.984(1.9); 0.008(2.1); 0.000(67.9); 0.008(2.0) Example I-101: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.172(1.9); 7.589(0.9); 7.579(10.1); 7.572(9.3); 7.568(4.4); 7.563(8.2); 7.556(2.2); 7.519(0.9); 7.429(0.6); 7.426(0.8); 7.420(5.7); 7.413(5.5); 7.408(3.6); 7.405(5.6); 7.401(2.5); 7.399(2.5); 7.396(4.0); 7.260(153.2); 7.033(16.0); 6.996(1.0); 5.298(0.7); 3.908(9.4); 3.890(9.6); 1.937(0.6); 1.928(0.8); 1.917(0.8); 1.909(1.2); 1.900(0.9); 1.890(0.8); 1.881(0.7); 1.767(1.8); 1.760(1.8); 1.736(5.4); 1.703(3.4); 1.680(1.2); 1.542(2.4); 1.284(0.9); 1.256(6.8); 1.224(2.5); 1.205(2.7); 1.191(1.8); 1.159(0.7); 1.091(1.0); 1.062(2.1); 1.039(1.7); 1.011(0.6); 1.001(0.6); 0.880(1.0); 0.008(1.6); 0.000(57.9); 0.008(1.8) Example I-102: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 10.415(1.5); 7.940(5.8); 4.038(0.7); 4.020(0.7); 3.868(3.0); 3.849(3.1); 3.309(67.0); 2.669(0.7); 2.549(0.6); 2.545(0.6); 2.523(2.0); 2.518(2.8); 2.509(37.4); 2.505(80.2); 2.500(111.4); 2.496(79.2); 2.491(36.2); 2.327(0.7); 2.086(16.0); 1.988(3.2); 1.663(1.0); 1.610(0.6); 1.572(1.1); 1.542(1.0); 1.247(1.1); 1.192(1.1); 1.175(2.2); 1.157(2.4); 1.133(1.2); 1.008(0.9); 0.979(0.7); 0.875(0.5); 0.858(1.7); 0.841(0.6); 0.000(13.0) Example I-103: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.930(7.6); 6.561(3.2); 5.754(1.5); 4.402(16.0); 3.859(4.1); 3.841(4.2); 3.345(39.8); 3.318(17.6); 3.299(0.7); 3.294(0.6); 2.674(0.5); 2.670(0.8); 2.665(0.6); 2.523(2.2); 2.519(3.3); 2.510(47.0); 2.505(102.9); 2.501(145.0); 2.496(103.1); 2.492(47.2); 2.469(0.8); 2.464(0.7); 2.332(0.7); 2.328(1.0); 2.323(0.7); 1.796(0.5); 1.788(0.7); 1.778(0.6); 1.677(1.1); 1.661(1.5); 1.608(0.9); 1.553(1.4); 1.523(1.4); 1.172(0.7); 1.145(2.6); 1.125(1.7); 1.025(0.6); 0.995(1.2); 0.966(1.0); 0.008(1.4); 0.000(52.6); 0.008(1.7) Example I-104: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 8.040(16.0); 7.858(1.1); 7.610(0.8); 7.602(0.8); 7.591 (4.9); 7.585(3.31; 7.581 (6.5); 7.572(8.1); 7.566(7.6); 7.558(1.3); 7.500(1.5); 7.496(1.4); 7.483(3.6); 7.481(3.4); 7.475(9.8); 7.472(9.1); 7.470(6.4); 7.464(13.5); 7.458(14.0); 7.449(1.4); 6.561(10.5); 5.753(3.8); 3.896(7.7); 3.878(7.8); 3.829(0.6); 3.811(0.6); 3.337(0.5); 3.309(130.6); 2.679(0.6); 2.674(1.3); 2.670(1.7); 2.665(1.3); 2.523(5.9); 2.518(8.4); 2.510(97.8); 2.505(206.9); 2.501 (285.4); 2.496(200.8); 2.492(91.3); 2.332(1.2); 2.328(1.7); 2.323(1.2); 1.850(0.8); 1.841(0.9); 1.831(1.1); 1.822(1.4); 1.813(1.2); 1.804(1.0); 1.794(0.9); 1.673(3.2); 1.618(1.9); 1.583(3.2); 1.553(3.1); 1.236(0.7); 1.187(1.6); 1.158(5.3); 1.139(3.8); 1.049(1.2); 1.019(2.6); 0.990(2.2); 0.966(0.8); 0.858(0.6); 0.000(13.8) Example I-105: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.271(3.0); 7.260(22.4); 7.190(0.6); 5.298(1.2); 3.846(1.4); 3.828(1.5); 3.419(9.5); 1.730(0.6); 1.699(0.6); 1.674(0.6); 1.572(16.0); 1.212(0.6); 0.000(8.1) Example I-106: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.262(17.6); 7.215(3.7); 5.552(1.1); 5.298(3.8); 3.834(2.9); 3.816(3.0); 2.375(3.7); 2.359(4.0); 1.956(0.8); 1.940(1.0); 1.923(0.8); 1.906(0.5); 1.721(0.8); 1.713(0.9); 1.677(0.9); 1.669(0.9); 1.206(0.9); 1.182(0.7); 1.066(16.0); 1.050(15.5); 1.011(0.5); 0.000(6.8) Example I-107: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.647(1.1); 7.519(1.7); 7.309(0.5); 7.292(0.6); 7.260(289.3); 6.996(1.7); 6.869(6.4); 6.788(0.6); 5.298(1.8); 3.867(4.0); 3.852(4.3); 3.192(1.8); 3.042(0.6); 2.750(1.8); 2.732(4.7); 2.713(5.0); 2.696(2.1); 1.811(1.8); 1.688(6.1); 1.656(7.4); 1.631(6.6); 1.328(0.9); 1.278(7.4); 1.259(16.0); 1.240(9.2); 1.220(4.4); 1.164(7.0); 1.003(3.5); 0.978(3.4); 0.882(2.5); 0.864(1.6); 0.008(3.0); 0.000(102.4); 0.008(4.2) Example I-108: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.265(9.1); 6.866(2.4); 6.863(2.3); 6.764(1.0); 6.761(1.0); 6.739(0.5); 6.736(1.1); 6.733(1.0); 6.174(0.5); 6.157(1.1); 6.146(0.5); 6.140(0.6); 6.129(1.0); 6.112(0.5); 4.956(1.0); 4.014(2.6); 4.011(2.4); 3.997(2.6); 3.994(2.4); 3.846(3.0); 3.827(3.0); 3.385(1.4); 3.345(16.0); 1.755(0.6); 1.749(0.6); 1.723(1.8); 1.691(1.4); 1.686(1.4); 1.255(0.6); 1.247(0.5); 1.216(1.1); 1.198(0.9); 1.189(0.8); 1.046(0.7); 1.017(0.6); 0.000(3.5) Example I-109: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.085(0.9); 8.081 (0.7); 7.260(82.7); 6.765(5.4); 6.761 (5.2); 6.503(0.9); 6.500(2.0); 6.496(1.9); 6.492(0.8); 6.476(1.0); 6.472(2.2); 6.468(2.1); 6.465(0.8); 6.037(1.1); 6.018(2.4); 6.010(1.1); 6.000(1.2); 5.991(2.1); 5.972(1.0); 5.036(2.0); 4.677(0.9); 3.842(7.1); 3.824(7.2); 2.153(1.2); 2.149(1.2); 2.135(3.0); 2.131(3.0); 2.116(3.1); 2.112(3.0); 2.097(1.4); 2.093(1.3); 1.909(0.6); 1.898(0.6); 1.890(0.8); 1.881(0.7); 1.871(0.6); 1.861(0.5); 1.748(1.4); 1.741(1.4); 1.718(4.0); 1.689(2.9); 1.573(1.4); 1.482(0.6); 1.464(2.1); 1.445(3.7); 1.426(3.8); 1.408(2.2); 1.390(0.6); 1.255(4.1); 1.212(2.3); 1.201(1.8); 1.196(1.8); 1.185(1.6); 1.154(0.5); 1.062(0.8); 1.035(1.6); 1.011(1.3); 1.004(1.3); 0.921(7.6); 0.903(16.0); 0.884(6.9); 0.008(1.8); 0.000(33.6); 0.008(1.1) Example I-110: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.085(2.8); 8.081(2.5); 7.519(1.0); 7.260(158.1); 7.211(1.4); 6.996(0.9); 6.753(12.1); 4.840(4.3); 4.676(3.2); 3.823(13.9); 3.805(13.7); 2.713(5.2); 2.694(7.4); 2.675(5.4); 2.448(0.6); 1.915(0.6); 1.905(1.1); 1.896(1.3); 1.887(1.4); 1.877(1.8); 1.869(1.6); 1.859(1.3); 1.850(1.2); 1.737(3.2); 1.708(7.3); 1.675(8.9); 1.665(9.0); 1.644(4.4); 1.625(1.9); 1.575(2.9); 1.421(1.1); 1.404(4.0); 1.401(4.0); 1.394(6.4); 1.386(12.9); 1.377(9.4); 1.368(8.8); 1.254(6.2); 1.237(2.6); 1.222(2.9); 1.205(6.0); 1.182(4.3); 1.151(1.1); 1.083(1.1); 1.065(2.8); 1.038(3.7); 1.008(3.1); 0.986(1.5); 0.978(1.1); 0.940(6.2); 0.923(16.0); 0.905(5.2); 0.880(1.0); 0.862(0.5); 0.008(2.3); 0.000(61.2); 0.008(3.0) Example I-111: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.74 (1H), 6.61 (2H), 3.77 (2H), 1.85-1.52 (5H), 1.24-0.97 (6H) Example I-112: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.256(8.2); 7.197(14.1); 7.194(14.2); 6.468(15.8); 5.753(16.0); 4.039(1.0); 4.021(1.0); 3.798(15.0); 3.780(15.3); 3.312(180.8); 2.676(0.7); 2.671(1.1); 2.666(0.8); 2.524(2.6); 2.520(3.8); 2.511(58.3); 2.506(127.2); 2.502(177.8); 2.497(126.7); 2.493(58.0); 2.333(0.8); 2.329(1.1); 2.324(0.8); 2.125(0.8); 2.112(1.9); 2.108(2.0); 2.104(2.0); 2.095(3.4); 2.092(3.4); 2.082(2.2); 2.079(2.1); 2.075(2.0); 2.062(0.9); 1.989(4.4); 1.800(0.8); 1.790(1.4); 1.781(1.7); 1.772(2.0); 1.763(2.5); 1.754(2.1); 1.744(1.8); 1.735(1.7); 1.726(1.0); 1.716(0.8); 1.671(4.2); 1.655(5.1); 1.605(3.4); 1.534(4.7); 1.503(5.0); 1.241(1.8); 1.193(2.0); 1.175(4.0); 1.165(2.8); 1.158(3.8); 1.141(9.2); 1.122(5.6); 1.018(2.0); 0.990(4.0); 0.959(5.9); 0.948(9.4); 0.944(9.8); 0.939(5.5); 0.934(5.4); 0.928(9.2); 0.923(9.0); 0.913(3.4); 0.875(1.0); 0.858(2.8); 0.840(1.1); 0.687(3.4); 0.677(9.1); 0.673(10.3); 0.664(9.4); 0.660(9.3); 0.649(2.8); 0.436(0.8); 0.428(1.6); 0.422(2.4); 0.415(1.4); 0.405(1.8); 0.399(2.9); 0.392(1.3); 0.343(0.8); 0.337(1.9); 0.330(2.8); 0.322(2.7); 0.315(4.0); 0.309(2.1); 0.301(0.9); 0.156(0.8); 0.149(0.9); 0.142(1.0); 0.136(0.7); 0.008(1.2); 0.000(42.9); 0.008(1.3); 0.379(0.8); 0.387(0.8); 0.402(1.4); 0.417(0.7); 0.425(0.7); 0.490(0.6) Example I-113: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.601(6.1); 6.466(4.5); 6.449(4.6); 6.269(5.3); 5.754(2.5); 5.621(3.2); 5.604(3.1); 3.980(2.2); 3.962(7.2); 3.945(7.2); 3.927(2.2); 3.840(4.9); 3.823(5.0); 3.312(26.2); 2.525(0.6); 2.520(0.9); 2.512(13.4); 2.507(29.5); 2.503(41.2); 2.498(29.3); 2.494(13.3); 1.741(0.6); 1.733(0.8); 1.724(0.7); 1.662(1.6); 1.619(2.2); 1.593(2.2); 1.249(7.6); 1.231(16.0); 1.213(7.4); 1.176(1.1); 1.155(3.0); 1.136(1.9); 1.043(0.7); 1.014(1.3); 0.986(1.1); 0.000(8.0) Example I-114: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 10.387(1.4); 7.534(11.3); 7.401(1.4); 7.361(3.2); 7.226(7.3); 7.206(16.0); 7.138(3.0); 6.629(2.4); 6.601(2.3); 6.269(1.6); 6.205(7.7); 6.158(14.8); 6.128(2.9); 6.113(3.0); 6.099(1.8); 6.088(4.0); 6.070(3.8); 6.056(2.0); 6.044(3.6); 6.030(1.6); 6.005(2.4); 5.987(2.7); 5.977(3.0); 5.960(2.7); 5.754(7.9); 5.589(2.0); 5.494(2.1); 5.442(1.9); 5.417(1.5); 5.140(5.8); 5.135(5.5); 5.114(5.0); 5.110(5.1); 5.053(1.4); 5.031(5.9); 5.027(5.3); 4.988(5.8); 4.984(5.2); 3.861(7.5); 3.842(8.4); 3.812(15.6); 3.794(15.4); 3.549(8.9); 3.534(8.5); 3.311(246.2); 2.671(2.3); 2.524(8.5); 2.520(11.5); 2.511(142.0); 2.506(303.0); 2.502(416.8); 2.497(289.5); 2.493(129.0); 2.329(2.5); 2.081(4.6); 1.985(6.6); 1.866(1.9); 1.850(2.4); 1.776(3.6); 1.730(12.2); 1.725(14.6); 1.721(15.1); 1.717(10.1); 1.713(11.7); 1.708(11.6); 1.662(8.7); 1.606(5.7); 1.562(7.4); 1.533(7.1); 1.235(8.6); 1.148(15.4); 1.130(9.5); 0.997(5.9); 0.853(1.5); 0.008(2.9); 0.000(86.0) Example I-115: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.784(4.6); 6.563(3.6); 3.838(3.2); 3.819(3.4); 3.311 (100.2); 2.670(0.6); 2.524(1.7); 2.519(2.4); 2.510(33.6); 2.506(73.8); 2.501(103.2); 2.496(72.8); 2.492(32.9); 2.328(0.6); 2.123(16.0); 1.988(1.2); 1.776(0.6); 1.659(1.2); 1.598(0.9); 1.546(1.2); 1.519(1.1); 1.298(0.5); 1.281(0.6); 1.244(1.6); 1.193(0.5); 1.175(1.1); 1.143(2.1); 1.123(1.4); 0.988(0.9); 0.958(0.8); 0.892(0.7); 0.874(2.0); 0.858(3.1); 0.841 (1.0); 0.008(1.0); 0.000(33.2); 0.008(0.9) Example I-116: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.682(0.6); 7.412(0.6); 7.396(1.8); 7.392(1.2); 7.377(1.9); 7.357(0.9); 7.354(0.8); 7.340(1.1); 7.330(2.0); 7.328(1.9); 7.326(1.8); 7.312(1.2); 7.260(79.4); 6.438(1.6); 3.448(2.4); 3.431(2.5); 2.600(0.7); 2.581(0.6); 1.541(16.0); 1.511(0.9); 1.502(1.0); 1.303(1.0); 1.295(3.5); 1.276(7.3); 1.264(4.0); 1.258(5.0); 1.244(0.9); 1.185(0.6); 1.166(0.9); 1.148(0.6); 1.027(0.7); 0.994(0.8); 0.958(0.7); 0.938(0.8); 0.899(2.2); 0.882(6.0); 0.864(2.5); 0.665(0.7); 0.634(0.6); 0.008(1.1); 0.000(28.4); 0.008(1.2) Example I-117: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.260(59.0); 6.754(2.9); 4.839(0.9); 3.825(3.2); 3.807(3.2); 2.698(1.1); 2.679(1.8); 2.660(1.2); 1.739(0.7); 1.709(1.6); 1.695(1.1); 1.676(2.1); 1.668(1.6); 1.664(1.5); 1.656(1.8); 1.647(1.0); 1.643(0.8); 1.636(1.2); 1.629(0.7); 1.622(0.7); 1.617(0.8); 1.605(1.0); 1.588(1.2); 1.572(1.0); 1.555(0.6); 1.313(1.0); 1.296(1.4); 1.284(1.0); 1.273(1.7); 1.256(3.3); 1.238(0.8); 1.206(1.3); 1.183(1.0); 1.040(0.8); 1.010(0.7); 0.979(0.6); 0.914(1.6); 0.910(16.0); 0.898(1.8); 0.894(15.4); 0.880(0.7); 0.873(0.5); 0.008(0.6); 0.000(22.5); 0.008(0.7) Example I-118: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.404(1.6); 7.226(10.2); 7.224(10.1); 6.629(3.1); 6.605(2.8); 6.601(3.4); 6.268(1.7); 6.205(11.5); 6.022(1.1); 6.005(4.1); 5.994(1.2); 5.987(4.0); 5.977(4.3); 5.960(4.2); 5.943(1.2); 5.923(0.7); 5.754(5.1); 3.861(11.1); 3.842(11.4); 3.309(80.5); 2.671(1.0); 2.524(2.6); 2.520(3.8); 2.511(61.0); 2.506(132.6); 2.502(185.1); 2.497(130.6); 2.493(59.2); 2.329(1.0); 1.989(1.4); 1.871(2.1); 1.866(2.0); 1.854(2.2); 1.850(2.2); 1.820(1.4); 1.801(2.0); 1.792(1.7); 1.774(1.4); 1.730(16.0); 1.726(15.6); 1.713(15.8); 1.708(16.0); 1.662(4.2); 1.573(4.1); 1.542(4.0); 1.236(0.9); 1.176(2.9); 1.151(7.6); 1.131(4.9); 1.013(3.3); 0.983(2.7); 0.008(2.7); 0.000(90.0); 0.009(2.5) Example I-119: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.859(0.8); 7.258(16.0); 6.015(9.9); 5.795(4.1); 5.753(3.0); 3.824(8.8); 3.806(8.8); 3.359(2.1); 3.310(319.7); 2.890(0.6); 2.675(1.3); 2.670(1.9); 2.666(1.3); 2.555(1.1); 2.550(1.9); 2.545(2.0); 2.540(1.8); 2.523(6.5); 2.519(9.1); 2.510(104.6); 2.506(222.8); 2.501(307.9); 2.496(217.8); 2.492(98.5); 2.337(0.6); 2.332(1.3); 2.328(1.8); 2.323(1.2); 2.202(5.0); 2.187(5.3); 2.171(3.7); 1.802(0.9); 1.793(1.1); 1.783(1.3); 1.774(1.8); 1.765(2.1); 1.751(3.0); 1.737(4.1); 1.723(3.7); 1.658(4.8); 1.650(6.1); 1.635(4.3); 1.620(3.0); 1.607(2.7); 1.565(3.3); 1.533(3.3); 1.354(1.8); 1.169(1.8); 1.145(6.1); 1.126(3.8); 1.030(1.3); 1.000(2.6); 0.971(2.1); 0.008(1.7); 0.000(53.5); 0.008(1.5) Example I-120: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.402(12.7); 7.361(3.3); 6.821(3.6); 6.782(3.9); 6.267(13.2); 6.130(2.1); 5.976(4.6); 5.960(5.1); 5.938(4.8); 5.922(4.6); 3.848(12.1); 3.830(12.4); 3.309(323.2); 2.670(3.2); 2.523(9.9); 2.518(14.1); 2.510(194.1); 2.505(423.3); 2.501(590.4); 2.496(417.4); 2.492(188.0); 2.327(2.9); 2.079(4.8); 1.988(2.8); 1.870(16.0); 1.866(16.0); 1.853(15.6); 1.849(15.8); 1.794(2.5); 1.660(5.0); 1.564(4.6); 1.536(4.5); 1.248(4.6); 1.175(4.3); 1.148(8.7); 1.128(5.4); 1.008(3.8); 0.982(3.4); 0.858(8.0); 0.841(2.8); 0.008(5.6); 0.000(195.8); 0.009(5.9) Example I-121: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.796(16.0); 7.490(0.7); 6.598(9.9); 3.847(9.3); 3.828(9.4); 3.312(110.3); 2.671(1.1); 2.528(15.0); 2.520(5.2); 2.511(81.3); 2.506(147.0); 2.502(203.8); 2.497(143.0); 2.493(64.6); 2.328(1.2); 2.138(1.0); 2.119(2.5); 2.101(3.5); 2.082(2.7); 2.063(1.1); 1.989(0.7); 1.826(2.6); 1.812(3.6); 1.794(4.2); 1.781(3.7); 1.651(5.2); 1.644(4.4); 1.631(4.6); 1.613(4.9); 1.590(3.0); 1.576(2.2); 1.550(6.0); 1.543(5.7); 1.534(5.1); 1.521(5.9); 1.437(0.6); 1.328(1.3); 1.312(3.1); 1.292(3.3); 1.280(3.3); 1.262(2.8); 1.244(2.6); 1.170(1.9); 1.143(6.3); 1.123(4.0); 0.992(2.9); 0.962(2.3); 0.858(2.8); 0.841(1.0); 0.008(1.8); 0.000(58.6); 0.008(1.7) Example I-122: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.799(16.0); 7.489(1.0); 6.588(12.0); 3.847(10.0); 3.829(10.1); 3.311(196.6); 2.671(1.3); 2.524(3.6); 2.520(5.3); 2.511(78.6); 2.506(172.9); 2.502(242.1); 2.497(171.0); 2.493(76.9); 2.434(14.0); 2.417(14.6); 2.329(1.2); 1.826(3.9); 1.792(4.7); 1.715(3.6); 1.683(6.3); 1.651(5.0); 1.606(3.8); 1.546(4.8); 1.519(4.9); 1.291(1.1); 1.260(3.4); 1.235(3.0); 1.228(4.6); 1.197(2.7); 1.177(3.2); 1.171(3.0); 1.147(8.2); 1.124(5.1); 1.090(2.5); 1.052(4.0); 1.022(4.6); 0.992(4.0); 0.963(2.5); 0.858(0.9); 0.000(31.4) Example I-123: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(1.2); 7.396(1.0); 7.382(18.7); 7.375(7.6); 7.369(7.4); 7.367(7.9); 7.361(1.2); 7.353(0.9); 7.347(1.3); 7.314(1.4); 7.308(1.7); 7.301(1.6); 7.298(1.5); 7.293(2.1); 7.284(1.5); 7.279(1.5); 7.259(221.9); 7.190(1.1); 6.995(1.2); 5.369(2.0); 3.872(16.0); 3.837(8.0); 3.819(8.1); 3.806(0.8); 1.895(0.6); 1.885(0.8); 1.876(0.8); 1.866(1.1); 1.858(0.9); 1.848(0.8); 1.838(0.7); 1.752(1.5); 1.721(2.4); 1.698(2.4); 1.668(2.9); 1.559(3.6); 1.257(1.1); 1.238(1.3); 1.206(2.9); 1.182(2.1); 1.150(0.6); 1.069(0.9); 1.038(2.0); 1.008(1.6); 0.977(0.5); 0.882(1.4); 0.864(0.6); 0.008(2.7); 0.000(83.4); 0.008(2.8) Example I-124: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.777(4.8); 7.769(6.1); 7.764(6.1); 7.757(6.3); 7.680(6.4); 7.677(6.4); 7.673(5.9); 7.670(4.9); 7.465(16.0); 7.265(5.9); 7.262(5.7); 7.253(5.6); 7.250(5.3); 5.753(4.3); 5.580(9.1); 3.875(8.3); 3.856(8.5); 3.308(336.8); 2.890(2.1); 2.732(2.1); 2.669(3.5); 2.523(9.4); 2.518(14.0); 2.510(201.8); 2.505(437.9); 2.500(609.5); 2.496(427.5); 2.491(191.5); 2.327(3.1); 1.660(3.2); 1.598(4.2); 1.567(3.3); 1.236(3.6); 1.153(5.4); 1.132(3.9); 1.020(2.6); 0.008(5.4); 0.000(205.2); 0.008(5.6) Example I-125: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.900(7.3); 7.898(7.9); 7.895(7.6); 7.893(6.4); 7.721(16.0); 6.702(4.7); 6.700(4.6); 6.694(10.2); 6.691(8.7); 6.682(9.3); 6.677(8.5); 6.674(4.2); 6.669(4.1); 5.969(10.1); 3.897(9.3); 3.879(9.5); 3.310(232.9); 3.258(1.4); 2.670(2.6); 2.551(0.8); 2.523(6.6); 2.518(9.2); 2.510(145.2); 2.505(306.4); 2.501(414.6); 2.496(296.0); 2.492(139.3); 2.327(2.4); 2.323(1.8); 1.988(1.8); 1.820(1.6); 1.666(3.5); 1.584(4.1); 1.556(3.5); 1.175(2.5); 1.153(5.8); 1.134(4.2); 1.020(2.8); 0.987(2.2); 0.008(3.6); 0.000(126.3); 0.008(4.9) Example I-126: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.520(0.6); 7.261(114.2); 6.997(0.7); 6.911(2.3); 6.908(2.3); 6.872(0.8); 6.791(6.3); 6.592(0.6); 6.589(0.6); 6.585(0.5); 6.554(0.6); 6.551(0.7); 6.546(0.6); 6.014(1.0); 5.998(1.0); 5.976(0.9); 5.959(0.9); 5.299(2.2); 3.944(0.6); 3.852(3.2); 3.838(7.7); 3.834(4.2); 3.819(7.4); 2.706(2.4); 2.689(3.8); 2.669(2.7); 2.142(0.9); 1.938(3.4); 1.933(3.6); 1.921(3.5); 1.917(3.7); 1.905(0.7); 1.896(0.8); 1.886(0.8); 1.878(1.1); 1.869(0.9); 1.859(0.8); 1.849(0.7); 1.751(1.9); 1.733(3.5); 1.714(6.2); 1.695(5.7); 1.676(4.8); 1.392(2.9); 1.332(0.6); 1.285(1.0); 1.256(4.3); 1.237(1.5); 1.206(3.4); 1.182(2.6); 1.152(0.7); 1.069(1.0); 1.052(8.3); 1.034(16.0); 1.016(8.0); 0.987(0.6); 0.880(0.8); 0.008(1.1); 0.000(40.9); 0.008(1.3) Example I-127: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.783(2.3); 7.519(1.9); 7.260(353.5); 7.213(2.9); 7.125(12.1); 7.110(12.1); 6.996(2.0); 5.298(1.5); 3.861(1.7); 3.836(15.3); 3.818(15.5); 2.354(0.8); 2.336(0.5); 1.882(1.2); 1.872(1.4); 1.862(1.6); 1.853(2.0); 1.844(1.7); 1.835(1.4); 1.826(1.3); 1.760(2.8); 1.735(4.4); 1.703(5.7); 1.674(5.4); 1.542(16.0); 1.256(11.6); 1.215(6.2); 1.192(4.5); 1.162(1.1); 1.084(1.8); 1.054(3.9); 1.025(3.1); 0.993(1.0); 0.897(0.8); 0.880(1.7); 0.862(0.8); 0.008(4.0); 0.000(134.5); 0.008(3.8) Example I-128: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.020(0.6); 7.519(0.6); 7.260(107.3); 7.242(3.2); 7.069(2.8); 7.054(2.9); 6.996(0.6); 3.819(3.5); 3.800(3.7); 2.710(0.6); 1.754(0.7); 1.730(1.0); 1.704(1.1); 1.676(1.3); 1.539(16.0); 1.522(0.7); 1.292(4.4); 1.273(9.4); 1.254(5.0); 1.212(1.4); 1.189(1.1); 1.049(0.9); 1.020(0.7); 0.899(0.6); 0.882(2.0); 0.864(0.8); 0.008(1.2); 0.000(39.5); 0.008(1.6); 0.019(1.1) Example I-129: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.898(6.3); 7.896(7.6); 7.894(8.2); 7.892(6.7); 7.866(7.1); 7.862(10.7); 7.858(5.4); 7.438(16.0); 6.740(7.4); 6.738(7.7); 6.736(7.5); 6.733(6.4); 5.785(9.9); 4.038(1.3); 4.020(1.2); 3.863(8.5); 3.845(8.6); 3.358(1.4); 3.308(209.7); 3.277(0.6); 3.259(0.8); 3.257(0.9); 2.674(1.6); 2.670(2.2); 2.665(1.6); 2.555(1.4); 2.551(1.5); 2.523(8.7); 2.518(12.9); 2.510(131.5); 2.505(273.4); 2.500(370.0); 2.496(263.0); 2.491(122.4); 2.457(2.4); 2.332(1.7); 2.327(2.2); 2.323(1.7); 1.988(5.5); 1.825(1.0); 1.816(1.1); 1.806(1.5); 1.798(1.2); 1.789(1.0); 1.780(0.9); 1.663(3.2); 1.587(3.7); 1.558(3.2); 1.236(1.8); 1.192(2.2); 1.175(4.6); 1.157(5.6); 1.151(5.6); 1.131(3.8); 1.043(1.2); 1.013(2.6); 0.984(2.1); 0.858(1.1); 0.008(4.0); 0.000(116.5); 0.008(4.1) Example I-130: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 8.513(16.0); 7.323(1.6); 4.039(0.6); 4.021 (0.6); 3.976(9.9); 3.958(9.9); 3.378(1.2); 2.671 (0.7); 2.593(59.0); 2.525(1.7); 2.520(2.5); 2.511(40.0); 2.507(88.2); 2.502(123.4); 2.498(86.2); 2.493(38.4); 2.329(0.7); 1.989(2.4); 1.910(1.0); 1.876(0.9); 1.867(1.1); 1.857(1.2); 1.848(1.5); 1.840(1.3); 1.829(1.0); 1.678(3.1); 1.623(1.9); 1.588(3.3); 1.560(3.1); 1.356(2.9); 1.232(0.6); 1.193(2.2); 1.175(3.1); 1.166(5.6); 1.145(3.8); 1.074(1.3); 1.046(2.5); 1.016(2.0); 0.996(0.7); 0.892(0.6); 0.875(1.0); 0.008(1.6); 0.000(58.5); 0.009(1.5) Example I-131: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.859(1.2); 7.744(5.5); 7.741(5.7); 7.731(5.8); 7.728(5.5); 7.602(16.0); 7.262(4.3); 7.259(4.7); 7.253(7.3); 7.250(6.4); 7.229(7.2); 7.221(4.4); 7.216(6.5); 7.208(4.4); 6.551(0.6); 5.638(8.8); 3.886(7.8); 3.868(7.9); 3.830(0.7); 3.811(0.7); 3.360(1.6); 3.346(1.6); 3.340(1.6); 3.337(1.2); 3.310(666.9); 3.286(1.8); 3.279(1.3); 3.260(0.7); 2.674(2.2); 2.670(3.1); 2.665(2.2); 2.550(1.1); 2.545(1.5); 2.540(1.8); 2.535(2.2); 2.530(2.6); 2.523(9.1); 2.518(13.5); 2.510(175.8); 2.505(376.5); 2.501(520.8); 2.496(367.4); 2.491(168.7); 2.469(1.1); 2.450(0.8); 2.332(2.3); 2.327(3.1); 2.323(2.2); 1.988(1.8); 1.804(1.3); 1.666(3.0); 1.595(3.8); 1.559(3.0); 1.236(1.3); 1.175(2.4); 1.152(4.9); 1.130(3.7); 1.042(1.1); 1.013(2.4); 0.985(2.0); 0.893(0.5); 0.874(0.8); 0.008(1.0); 0.000(31.7); 0.008(1.0) Example I-132: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.661(16.0); 6.558(7.3); 6.550(7.5); 6.278(4.8); 6.275(4.8); 6.270(4.5); 6.267(4.3); 5.971(9.8); 3.888(8.0); 3.870(7.9); 3.314(422.9); 2.670(1.7); 2.524(5.0); 2.510(103.4); 2.506(225.4); 2.501(315.0); 2.496(223.7); 2.492(101.9); 2.352(27.5); 2.328(1.8); 2.073(3.6); 1.814(1.5); 1.657(2.9); 1.575(3.0); 1.546(2.8); 1.152(5.0); 1.129(3.6); 1.013(2.4); 0.984(2.1); 0.000(39.1) Example I-133: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.562(12.1); 6.211(7.5); 4.495(4.5); 4.489(5.0); 4.407(5.7); 4.402(5.2); 3.982(2.1); 3.964(6.6); 3.947(6.5); 3.929(2.0); 3.863(6.2); 3.845(6.5); 3.312(184.1); 2.670(1.1); 2.523(2.6); 2.510(63.2); 2.506(137.7); 2.501(192.4); 2.496(136.2); 2.492(61.6); 2.328(1.0); 1.786(1.1); 1.661(2.4); 1.607(1.5); 1.567(2.5); 1.537(2.2); 1.326(7.3); 1.308(16.0); 1.291(7.0); 1.235(0.8); 1.175(1.5); 1.149(4.1); 1.131(2.9); 1.008(1.8); 0.980(1.6); 0.858(0.8); 0.008(1.8); 0.000(61.3); 0.008(1.8) Example I-134: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.261(20.1); 7.130(4.6); 5.299(2.1); 4.013(16.0); 3.874(2.8); 3.856(2.8); 2.268(15.4); 1.717(1.1); 1.685(0.9); 1.677(0.8); 1.258(0.7); 1.255(0.6); 1.210(0.8); 1.190(0.6); 1.184(0.6); 1.047(0.5); 0.000(7.7) Example I-135: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.611(16.0); 7.519(0.7); 7.260(118.6); 6.996(0.7); 5.299(1.4); 5.283(3.5); 3.891(9.6); 3.873(9.7); 1.883(0.7); 1.874(0.8); 1.864(0.9); 1.855(1.2); 1.846(1.0); 1.836(0.8); 1.827(0.7); 1.776(1.5); 1.744(2.2); 1.689(2.7); 1.662(2.2); 1.578(1.2); 1.284(0.8); 1.254(2.9); 1.218(2.9); 1.196(2.2); 1.163(0.6); 1.072(0.8); 1.042(1.9); 1.012(1.6); 0.008(1.3); 0.000(43.3); 0.008(1.3) Example I-136: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.518(3.8); 7.434(1.8); 7.412(2.3); 7.392(2.3); 7.371(2.1); 7.310(1.1); 7.260(665.7); 7.240(13.6); 7.237(13.3); 7.015(2.1); 6.999(2.5); 6.995(4.3); 6.991(3.9); 6.975(3.8); 6.967(2.1); 6.952(2.1); 5.373(4.7); 5.126(16.0); 1.581(8.8); 1.284(2.8); 1.255(12.7); 0.880(2.1); 0.008(8.6); 0.000(233.7); 0.008(6.6); 0.150(0.8) Example I-137: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.64 (1H), 6.67 (1H), 4.45 (1H), 4.11-4.03 (1H), 3.92-3.85 (1H), 2.35-2.25 (1H), 1.98-1.42 (6H), 1.37 (18H), 1.28-1.18 (2H) Example I-138: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.520(1.6); 5.606(0.8); 3.950(0.5); 3.844(0.6); 3.311(40.2); 2.505(28.0); 2.500(39.7); 2.496(31.8); 1.656(0.9); 1.625(0.9); 1.592(0.6); 1.455(0.6); 1.434(16.0); 1.419(1.2); 1.240(0.6); 1.153(0.8); 1.131(0.6); 0.858(0.6); 0.000(1.8) Example I-139: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 9.210(1.1); 8.153(3.1); 7.844(1.7); 7.842(1.7); 7.826(1.3); 7.814(1.3); 7.807(0.8); 7.336(1.4); 7.324(1.4); 6.871(1.6); 6.629(0.8); 5.727(1.1); 3.917(2.1); 3.899(2.2); 3.319(81.3); 2.670(0.5); 2.501(85.3); 2.327(0.5); 2.183(2.4); 1.988(0.9); 1.670(1.1); 1.595(1.2); 1.564(1.0); 1.356(16.0); 1.237(1.0); 1.192(0.8); 1.174(1.0); 1.158(1.6); 1.138(1.2); 1.004(0.9); 0.976(0.7); 0.000(2.0) Example I-140: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 9.255(0.8); 8.258(3.9); 7.826(1.4); 7.823(1.5); 7.813(1.5); 7.810(1.4); 7.427(1.4); 7.424(1.4); 7.418(1.6); 7.415(1.4); 7.240(1.5); 7.231(1.4); 7.227(1.5); 7.218(1.3); 6.870(1.2); 6.628(0.7); 5.829(0.8); 4.038(0.8); 4.020(0.8); 3.920(1.8); 3.902(1.8); 3.312(61.4); 2.669(0.7); 2.523(2.2); 2.518(3.2); 2.509(37.2); 2.505(78.9); 2.500(108.5); 2.496(76.3); 2.491(34.7); 2.327(0.6); 2.183(1.9); 1.988(3.4); 1.691(0.5); 1.668(0.7); 1.593(0.8); 1.559(0.7); 1.355(16.0); 1.236(0.6); 1.192(1.3); 1.174(2.2); 1.157(1.9); 1.135(0.8); 1.000(0.6); 0.970(0.5); 0.008(2.0); 0.000(61.6); 0.008(1.8) Example I-141: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.260(33.2); 7.130(4.7); 4.272(1.2); 4.254(3.7); 4.236(3.8); 4.219(1.2); 3.874(2.8); 3.856(2.8); 2.277(16.0); 1.748(0.6); 1.721(1.5); 1.688(1.2); 1.684(1.2); 1.364(4.0); 1.347(8.3); 1.329(3.9); 1.241(0.5); 1.210(1.0); 1.186(0.8); 1.048(0.7); 1.019(0.6); 0.000(13.0); 0.008(0.6) Example Example I-142: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.820(0.5); 7.518(1.4); 7.260(235.0); 7.253(0.9); 7.252(0.7); 7.251(0.6); 6.996(1.6); 6.848(6.3); 5.298(1.4); 4.800(1.2); 4.120(1.4); 4.102(4.5); 4.085(4.5); 4.067(1.4); 2.574(1.4); 2.284(0.9); 2.275(0.6); 2.239(16.0); 2.227(0.7); 2.043(1.2); 1.880(0.5); 1.751(0.8); 1.721(2.2); 1.690(1.6); 1.538(10.7); 1.304(0.7); 1.284(1.2); 1.276(1.6); 1.256(6.5); 1.241(1.1); 1.232(0.8); 1.214(1.6); 1.203(6.5); 1.186(12.6); 1.168(5.6); 1.061(0.5); 1.033(0.9); 1.009(0.8); 0.899(1.1); 0.882(3.3); 0.864(1.4); 0.008(2.7); 0.000(91.0); 0.008(2.6) Example I-143: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.520(0.6); 7.261 (98.9); 6.997(0.5); 6.801(9.8); 6.177(0.8); 6.164(1.8); 6.151 (1.7); 6.138(2.1); 6.134(1.0); 6.126(1.0); 6.121 (2.1); 6.108(1.9); 6.095(2.1); 6.082(1.0); 5.298(1.2); 5.293(2.9); 5.290(2.9); 5.285(1.2); 5.272(1.1); 5.267(2.7); 5.264(2.8); 5.259(1.2); 5.120(1.2); 5.115(2.8); 5.112(2.7); 5.107(1.2); 5.077(1.1); 5.072(2.6); 5.069(2.5); 5.064(1.1); 4.870(4.7); 3.832(11.5); 3.814(11.6); 3.513(4.8); 3.512(5.0); 3.506(4.1); 3.500(4.9); 3.499(4.8); 2.575(1.4); 2.170(0.5); 1.914(0.8); 1.904(0.9); 1.894(1.0); 1.885(1.3); 1.876(1.1); 1.866(0.9); 1.858(0.8); 1.747(2.0); 1.709(4.3); 1.677(3.7); 1.667(3.7); 1.645(1.2); 1.626(0.7); 1.574(16.0); 1.387(0.6); 1.369(1.0); 1.350(1.0); 1.332(0.7); 1.318(0.6); 1.297(0.7); 1.278(0.9); 1.256(1.3); 1.247(1.3); 1.240(1.7); 1.209(3.5); 1.189(2.5); 1.183(2.4); 1.151(0.7); 1.069(1.2); 1.040(2.4); 1.010(1.9); 0.986(0.6); 0.979(0.7); 0.941(2.2); 0.923(4.5); 0.904(1.9); 0.008(1.0); 0.000(33.5); 0.008(1.0) Example I-144: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 6.29 (2H), 5.56 (1H), 4.69 (1H), 3.77-3.73 (1H), 3.55-3.51 (1H), 3.39-3.30 (1H), 3.20-3.15 (1H), 1-68-1.62 (5H), 1.24-0.85 (6H) Example I-145: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.595(8.0); 7.586(7.9); 6.244(8.3); 6.236(8.1); 6.156(0.9); 6.141(2.7); 6.125(2.6); 6.108(0.8); 6.039(0.8); 6.023(2.6); 6.007(2.7); 5.991(0.8); 5.753(3.7); 3.902(1.6); 3.884(1.7); 3.870(5.8); 3.852(11.3); 3.834(5.9); 3.820(1.6); 3.802(1.6); 3.363(1.0); 3.314(256.2); 2.676(0.7); 2.671(1.0); 2.666(0.7); 2.552(0.6); 2.547(0.6); 2.524(3.2); 2.520(4.7); 2.511(58.5); 2.507(126.0); 2.502(175.1); 2.498(124.6); 2.493(57.3); 2.333(0.8); 2.329(1.0); 2.324(0.8); 2.086(3.0); 1.989(0.8); 1.829(0.7); 1.820(1.2); 1.810(1.5); 1.801(1.7); 1.792(2.2); 1.783(1.8); 1.773(1.6); 1.764(1.5); 1.755(0.9); 1.734(12.1); 1.718(12.4); 1.676(16.0); 1.660(15.8); 1.611(2.9); 1.561(4.2); 1.533(4.3); 1.485(0.6); 1.468(0.6); 1.235(6.5); 1.208(0.7); 1.176(2.8); 1.154(8.5); 1.134(5.3); 1.041(1.7); 1.012(3.6); 0.982(2.9); 0.960(1.0); 0.858(0.7); 0.854(1.0); 0.008(0.7); 0.000(22.0); 0.008(0.7) Example I-146: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 8.014(3.4); 8.012(3.0); 7.898(3.2); 7.897(3.5); 7.894(2.9); 7.546(4.4); 5.755(5.6); 5.753(8.3); 5.752(7.3); 5.617(1.6); 3.871(3.3); 3.855(16.0); 3.370(0.7); 3.322(12.1); 2.501(43.5); 1.988(1.4); 1.911(2.7); 1.909(4.3); 1.908(3.9); 1.820(0.6); 1.666(1.5); 1.598(2.0); 1.567(1.6); 1.356(1.9); 1.235(1.2); 1.192(0.8); 1.175(1.5); 1.156(2.5); 1.152(2.5); 1.132(1.8); 1.043(0.6); 1.014(1.2); 0.986(1.0); 0.002(2.3); 0.000(3.6); 0.001(3.3) Example I-147: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.402(11.1); 7.056(9.9); 6.260(6.5); 6.251(6.4); 4.861(0.6); 4.845(2.0); 4.835(2.0); 4.828(2.0); 4.819(2.0); 4.802(0.5); 4.056(1.2); 4.038(3.6); 4.021(3.6); 4.003(1.2); 3.893(1.9); 3.874(2.0); 3.861(2.8); 3.842(2.8); 3.757(2.8); 3.739(2.9); 3.725(1.9); 3.707(1.9); 3.359(1.9); 3.309(182.9); 3.258(0.9); 3.243(0.7); 2.679(0.6); 2.674(1.2); 2.670(1.7); 2.665(1.2); 2.560(0.8); 2.556(1.3); 2.551(1.6); 2.546(1.0); 2.542(0.7); 2.523(5.2); 2.518(7.0); 2.510(92.8); 2.505(201.9); 2.501(282.4); 2.496(200.2); 2.491(91.5); 2.471(0.5); 2.466(0.6); 2.461(0.6); 2.456(0.6); 2.336(0.5); 2.332(1.2); 2.327(1.7); 2.323(1.2); 2.318(0.6); 1.988(16.0); 1.801(0.7); 1.793(0.9); 1.783(1.0); 1.774(1.3); 1.765(1.1); 1.755(1.0); 1.746(0.9); 1.666(2.8); 1.612(1.8); 1.581(1.7); 1.558(2.5); 1.456(14.7); 1.439(14.6); 1.236(0.9); 1.192(4.8); 1.175(10.3); 1.157(7.4); 1.150(4.7); 1.136(3.0); 1.040(1.0); 1.011(2.1); 0.981(1.8); 0.050(0.8); 0.008(3.4); 0.000(120.3); 0.008(3.8) Example I-148: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 13.275(0.6); 7.956(11.4); 7.952(11.6); 7.806(12.2); 7.802(11.5); 7.539(16.0); 5.618(3.7); 3.872(8.2); 3.854(8.3); 3.329(133.4); 2.674(2.0); 2.670(2.8); 2.665(2.0); 2.554(1.1); 2.550(1.7); 2.545(1.8); 2.540(1.7); 2.536(1.5); 2.523(8.9); 2.518(13.7); 2.510(166.0); 2.505(347.7); 2.501(477.5); 2.496(342.9); 2.492(162.1); 2.332(2.1); 2.327(2.8); 2.323(2.0); 1.988(1.1); 1.908(1.4); 1.819(1.6); 1.665(3.7); 1.597(4.8); 1.569(3.8); 1.236(1.5); 1.175(2.3); 1.152(6.1); 1.132(4.3); 1.042(1.5); 1.014(3.0); 0.985(2.5); 0.008(1.3); 0.000(38.0); 0.008(1.4) Example I-149: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 11.534(6.8); 8.462(9.3); 5.753(8.3); 4.021(0.5); 3.975(8.4); 3.957(8.4); 3.308(188.1); 3.258(0.7); 2.674(1.6); 2.670(2.2); 2.665(1.5); 2.560(45.0); 2.523(5.8); 2.518(9.1); 2.510(132.3); 2.505(283.4); 2.501(390.2); 2.496(274.6); 2.491(123.9); 2.450(1.4); 2.446(1.3); 2.332(1.8); 2.327(2.4); 2.323(1.7); 2.269(1.2); 2.105(16.0); 2.072(1.0); 2.035(0.8); 1.988(2.2); 1.874(1.0); 1.865(1.1); 1.857(1.4); 1.847(1.2); 1.837(1.0); 1.680(3.2); 1.661(2.4); 1.625(2.0); 1.596(3.4); 1.565(3.0); 1.258(0.9); 1.236(2.8); 1.192(2.2); 1.174(4.7); 1.168(5.5); 1.157(3.0); 1.148(3.8); 1.125(1.3); 1.080(1.3); 1.051 (2.6); 1.023(2.1); 0.854(0.7); 0.146(0.8); 0.008(7.1); 0.000(244.3); 0.008(7.2); 0.050(0.6); 0.149(0.9) Example I-150: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 8.02 (2H), 7.84 (1H), 7.51 (2H), 5.61 (2H), 3.87 (2H), 1.85-1.56 (6H), 1.23-0.99 (5H) Example I-151: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.314(16.0); 7.518(2.5); 7.492(3.7); 7.488(1.6); 7.474(6.7); 7.472(6.3); 7.458(2.3); 7.453(5.8); 7.351(3.2); 7.348(2.0); 7.332(4.4); 7.313(2.0); 7.310(1.5); 7.288(0.7); 7.260(396.4); 7.212(6.1); 7.209(8.2); 7.204(2.0); 7.193(3.6); 7.190(6.1); 7.188(5.5); 6.995(2.3); 6.454(0.9); 3.962(9.0); 3.944(9.0); 1.923(1.2); 1.905(0.8); 1.785(2.0); 1.751(4.6); 1.714(3.7); 1.639(0.9); 1.583(2.2); 1.548(14.6); 1.510(1.1); 1.503(1.1); 1.454(0.6); 1.410(2.3); 1.379(2.2); 1.304(1.0); 1.265(2.9); 1.241(2.8); 1.220(3.2); 1.173(0.7); 1.119(1.2); 1.089(2.2); 1.060(1.8); 1.028(0.6); 0.898(1.1); 0.882(3.0); 0.864(1.1); 0.146(0.6); 0.008(4.9); 0.000(146.4); 0.008(4.3); 0.150(0.6) Example I-152: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.94 (1H), 4.48 (1H), 4.10-4.03 (1H), 3.94-3.85 (1H), 2.35-2.28 (1H), 1.98-1.42 (6H), 1.37 (9H), 1.36 (9H), 1.28-1.18 (2H) Example I-153: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.94 (1H), 4.48 (1H), 4.10-4.03 (1H), 3.94-3.85 (1H), 2.35-2.28 (1H), 1.98-1.42 (6H), 1.37 (9H), 1.36 (9H), 1.28-1.18 (2H) Example I-154: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.94 (1H), 4.48 (1H), 4.10-4.03 (1H), 3.94-3.85 (1H), 2.35-2.28 (1H), 1.98-1.42 (6H), 1.37 (9H), 1.36 (9H), 1.28-1.18 (2H) Example I-155: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.520(1.2); 7.286(43.4); 7.261(204.1); 7.211(0.6); 6.997(1.1); 5.396(8.3); 4.255(8.2); 4.248(8.5); 4.131(0.8); 4.108(6.7); 4.093(7.0); 4.075(8.0); 4.060(8.1); 3.773(8.8); 3.752(9.0); 3.740(7.3); 3.719(7.5); 2.418(1.1); 2.411(1.2); 2.402(1.8); 2.396(3.5); 2.390(2.4); 2.380(4.1); 2.374(4.0); 2.365(2.5); 2.358(3.4); 2.343(1.2); 2.337(1.1); 2.099(1.0); 2.080(4.1); 2.061(2.6); 2.050(4.2); 2.044(5.7); 1.811(3.9); 1.803(3.6); 1.777(6.2); 1.773(6.1); 1.750(7.6); 1.745(8.9); 1.730(4.0); 1.723(4.9); 1.714(6.3); 1.707(4.2); 1.683(3.4); 1.676(3.8); 1.652(4.7); 1.589(1.6); 1.557(6.7); 1.548(7.7); 1.532(16.0); 1.524(12.6); 1.510(6.4); 1.502(4.7); 1.488(1.0); 1.478(0.6); 1.469(0.6); 1.350(1.4); 1.326(2.4); 1.316(2.5); 1.308(2.7); 1.294(2.7); 1.284(2.6); 1.277(2.9); 1.259(5.1); 1.255(4.8); 1.241(1.6); 0.880(0.6); 0.069(0.5); 0.008(2.7); 0.000(77.5); 0.008(2.7) Example I-156: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.521(0.9); 7.312(0.7); 7.286(48.7); 7.277(2.0); 7.262(163.4); 7.230(0.6); 6.998(0.9); 5.396(12.9); 4.255(7.8); 4.249(8.0); 4.131(1.1); 4.113(1.8); 4.108(6.9); 4.093(7.2); 4.075(8.4); 4.060(8.5); 3.773(9.0); 3.752(9.4); 3.740(7.7); 3.719(7.8); 2.956(2.0); 2.884(1.7); 2.418(1.1); 2.411(1.2); 2.403(1.8); 2.396(3.5); 2.390(2.4); 2.380(4.0); 2.374(3.9); 2.365(2.5); 2.358(3.4); 2.352(1.9); 2.343(1.3); 2.337(1.2); 2.089(2.1); 2.080(3.9); 2.062(2.6); 2.050(4.2); 2.044(6.7); 1.811(3.6); 1.803(3.4); 1.780(5.6); 1.777(5.8); 1.773(5.7); 1.750(7.3); 1.745(8.4); 1.730(3.7); 1.725(4.2); 1.722(4.5); 1.718(5.3); 1.714(5.7); 1.707(3.7); 1.690(1.1); 1.683(1.7); 1.676(1.6); 1.581(8.8); 1.557(8.6); 1.548(8.4); 1.540(7.8); 1.532(16.0); 1.524(12.7); 1.515(5.0); 1.510(6.8); 1.502(5.1); 1.489(1.1); 1.478(0.8); 1.469(0.7); 1.407(0.6); 1.350(1.4); 1.333(2.1); 1.326(2.4); 1.316(2.6); 1.308(2.8); 1.299(2.6); 1.293(2.7); 1.284(2.8); 1.277(3.3); 1.259(6.1); 1.255(5.2); 1.241(2.1); 0.880(0.8); 0.008(2.2); 0.000(61.8); 0.008(2.4) Example I-157: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 9.60 (1H), 8.91 (1H), 8.80 (1H), 4.05-3.92 (2H), 2.62 (3H), 1.85-1.57 (6H), 1.23-1.02 (5H) Example I-158: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 10.2 (1H), 9.48 (1H), 9.01 (1H), 4.02 (2H), 2.62 (3H), 1.85-1.57 (6H), 1.24-1.02 (5H) Example I-159: .sup.1H-NMR(400.0 MHz, CDCl3): = 9.560(1.0); 7.411(3.8); 7.260(63.5); 6.136(0.9); 4.231(1.7); 4.146(0.8); 4.133(0.9); 4.113(1.1); 4.100(1.1); 3.806(0.9); 3.784(1.1); 3.772(1.0); 3.751(0.9); 2.375(0.9); 2.088(0.8); 2.060(0.8); 1.784(1.4); 1.749(1.8); 1.721(1.4); 1.536(16.0); 1.266(1.5); 0.882(1.0); 0.000(22.8) Example I-160: .sup.1H-NMR(400.0 MHz, CDCl3): = 9.563(0.7); 7.519(0.6); 7.411(8.3); 7.260(120.2); 6.996(0.7); 6.135(0.8); 4.236(1.4); 4.229(1.4); 4.147(1.2); 4.132(1.2); 4.114(1.4); 4.099(1.4); 3.806(1.5); 3.784(1.5); 3.773(1.2); 3.751(1.3); 2.394(0.5); 2.374(0.6); 2.356(0.6); 2.091(0.7); 2.062(0.7); 1.820(0.6); 1.787(1.2); 1.755(1.2); 1.749(1.5); 1.735(0.6); 1.719(1.0); 1.568(1.1); 1.559(1.0); 1.536(16.0); 1.521(1.4); 1.512(1.2); 1.303(0.6); 1.258(1.1); 0.882(1.4); 0.864(0.5); 0.008(1.4); 0.000(42.8); 0.008(1.4) Example I-161: .sup.1H-NMR(400.0 MHz, CDCl3): = 9.597(6.4); 7.519(2.8); 7.427(58.6); 7.373(0.6); 7.310(1.6); 7.293(1.1); 7.260(475.8); 7.232(2.6); 7.209(2.4); 7.146(0.8); 6.996(2.8); 5.299(16.0); 4.228(9.4); 4.221(10.0); 4.153(7.7); 4.139(8.1); 4.120(9.4); 4.105(9.5); 3.810(9.8); 3.788(10.1); 3.776(8.5); 3.755(8.6); 2.412(1.2); 2.406(1.4); 2.398(2.2); 2.391(3.7); 2.385(2.9); 2.373(4.6); 2.352(4.4); 2.338(1.9); 2.332(1.7); 2.090(4.8); 2.061(4.9); 1.822(4.0); 1.787(8.2); 1.754(8.6); 1.748(10.9); 1.734(4.9); 1.718(7.4); 1.711(4.7); 1.686(2.2); 1.679(2.0); 1.568(9.0); 1.544(41.5); 1.520(12.3); 1.512(10.4); 1.432(2.1); 1.332(3.5); 1.304(4.0); 1.292(3.9); 1.280(4.0); 1.256(10.7); 0.881(1.9); 0.864(1.1); 0.146(0.6); 0.008(6.2); 0.000(175.7); 0.008(7.5); 0.052(1.0); 0.149(0.8) Example I-162: .sup.1H-NMR(400.0 MHz, CDCl3): = 9.600(3.4); 7.520(0.8); 7.427(32.5); 7.261(145.0); 6.997(0.8); 5.299(16.0); 4.228(5.2); 4.222(5.4); 4.153(4.4); 4.138(4.5); 4.120(5.2); 4.105(5.3); 3.810(5.7); 3.788(5.8); 3.777(4.8); 3.755(4.9); 2.412(0.7); 2.406(0.7); 2.398(1.2); 2.391(2.0); 2.384(1.5); 2.372(2.4); 2.358(1.7); 2.352(2.1); 2.346(1.1); 2.338(0.8); 2.331(0.7); 2.091(2.6); 2.073(1.6); 2.061(2.6); 2.053(1.6); 2.043(0.7); 1.826(2.1); 1.822(2.1); 1.801(1.5); 1.787(4.4); 1.754(4.4); 1.748(5.8); 1.734(2.2); 1.726(2.8); 1.718(3.7); 1.711(2.1); 1.695(0.6); 1.686(0.9); 1.680(0.8); 1.596(1.1); 1.568(5.0); 1.552(10.9); 1.541(9.9); 1.532(7.1); 1.520(5.4); 1.512(4.7); 1.358(0.8); 1.333(1.6); 1.322(1.7); 1.316(1.7); 1.304(1.8); 1.292(1.7); 1.281(1.7); 1.257(3.8); 0.882(0.9); 0.008(1.6); 0.006(0.7); 0.000(54.0); 0.008(1.7) Example I-163: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.838(7.0); 7.823(6.8); 7.627(2.0); 7.610(2.2); 7.602(2.7); 7.584(2.8); 7.575(2.1); 7.558(2.0); 7.457(1.7); 7.440(1.9); 7.435(2.0); 7.430(2.0); 7.418(1.9); 7.413(2.0); 7.408(1.8); 7.390(1.6); 6.654(10.8); 5.173(0.6); 5.138(16.0); 3.410(0.5); 3.370(0.8); 3.359(1.5); 3.345(2.3); 3.310(568.5); 3.278(0.6); 3.261(0.7); 2.679(1.2); 2.674(2.6); 2.670(3.6); 2.665(2.6); 2.660(1.2); 2.600(0.8); 2.523(13.7); 2.519(19.1); 2.510(198.2); 2.505(409.8); 2.501(563.2); 2.496(385.1); 2.492(174.3); 2.337(1.1); 2.332(2.4); 2.328(3.4); 2.323(2.4); 2.318(1.1); 2.072(1.1); 1.988(1.5); 1.236(0.5); 1.175(0.8); 0.008(2.0); 0.000(62.5); 0.008(1.9) Example I-164: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 8.05 (1H), 7.65-7.48 (2H), 5.18 (2H), 1.38 (18H) Example I-165: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 11.726(6.9); 7.965(6.6); 7.949(6.5); 7.632(2.1); 7.615(2.1); 7.606(2.9); 7.588(3.0); 7.581(2.2); 7.563(2.1); 7.532(1.6); 7.514(2.1); 7.482(2.1); 7.465(1.8); 6.658(4.2); 6.526(11.2); 6.393(4.7); 5.753(8.6); 5.178(16.0); 3.311(181.0); 2.670(1.7); 2.524(4.8); 2.510(95.7); 2.506(202.3); 2.501(279.8); 2.497(195.7); 2.492(89.9); 2.451(1.2); 2.328(1.4); 1.988(2.3); 1.235(5.8); 1.175(1.3); 0.000(47.8); 0.009(1.4) Example I-166: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.798(4.3); 6.491(2.9); 4.807(6.7); 3.891(2.2); 3.873(2.3); 3.716(16.0); 3.687(1.9); 3.309(150.6); 2.669(1.1); 2.523(5.6); 2.518(7.7); 2.510(85.0); 2.505(177.2); 2.500(243.6); 2.496(166.7); 2.491(74.8); 2.315(15.9); 2.189(1.8); 1.667(1.1); 1.533(1.0); 1.247(0.9); 1.157(1.7); 1.018(0.8); 0.858(1.5); 0.008(0.9); 0.000(39.5); 0.009(1.4) Example I-167: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.260(86.1); 7.134(4.7); 4.007(3.8); 3.990(3.8); 3.874(2.8); 3.856(2.8); 2.302(16.0); 1.723(1.3); 1.690(1.0); 1.556(0.7); 1.255(0.6); 1.217(1.0); 1.212(1.2); 1.200(1.2); 1.187(0.9); 1.182(0.9); 1.050(0.6); 0.612(1.3); 0.609(1.4); 0.604(0.6); 0.598(0.6); 0.592(1.4); 0.589(1.2); 0.578(0.6); 0.345(0.6); 0.333(1.7); 0.330(1.4); 0.321(1.3); 0.318(1.7); 0.008(1.0); 0.000(31.6); 0.008(0.9) Example I-168: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.788(4.3); 6.720(2.8); 6.054(0.7); 6.028(0.8); 6.011 (0.9); 5.985(0.9); 5.754(0.9); 5.381 (1.2); 5.377(1.3); 5.338(1.1); 5.334(1.1); 5.287(0.5); 5.284(1.1); 5.279(1.0); 5.258(1.0); 5.253(1.0); 4.667(1.4); 4.663(2.4); 4.660(1.5); 4.653(1.5); 4.649(2.3); 4.646(1.4); 3.901(2.1); 3.883(2.1); 3.315(15.0); 2.521(0.5); 2.512(6.1); 2.508(12.9); 2.503(18.0); 2.499(12.5); 2.494(5.7); 2.282(16.0); 1.665(0.8); 1.564(0.7); 1.535(0.7); 1.153(1.3); 1.133(0.9); 1.020(0.6); 0.000(6.3) Example I-169: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.262(14.6); 7.129(4.9); 5.974(1.5); 5.299(2.2); 4.438(1.0); 4.422(1.4); 4.407(1.0); 3.872(3.1); 3.854(3.1); 2.267(16.0); 1.754(0.6); 1.748(0.6); 1.723(1.7); 1.690(1.3); 1.685(1.2); 1.596(0.5); 1.325(15.5); 1.310(15.4); 1.255(1.0); 1.243(0.5); 1.210(1.0); 1.194(0.7); 1.185(0.8); 1.050(0.7); 1.021(0.6); 0.000(5.2) Example I-170: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 8.349(16.0); 3.947(7.2); 3.929(7.4); 3.507(0.6); 3.363(3.6); 3.313(460.0); 2.674(3.4); 2.670(4.9); 2.665(3.6); 2.598(0.5); 2.555(3.7); 2.551(5.0); 2.546(4.6); 2.541(4.2); 2.523(16.5); 2.518(23.6); 2.510(274.4); 2.505(571.0); 2.501(787.7); 2.496(548.7); 2.492(253.0); 2.332(3.3); 2.327(4.7); 2.323(3.4); 2.318(1.7); 2.072(0.7); 1.771(1.3); 1.660(2.9); 1.607(1.9); 1.564(2.9); 1.536(2.9); 1.298(1.3); 1.259(2.3); 1.236(7.8); 1.176(1.9); 1.149(5.1); 1.129(3.6); 1.012(2.4); 0.981(1.9); 0.854(1.4); 0.836(0.7); 0.050(0.5); 0.008(3.9); 0.000(149.1); 0.008(5.2); 0.150(0.5) Example I-171: .sup.1H-NMR(400.0 MHz, CDCl3): = 9.464(4.1); 7.763(1.3); 7.520(1.0); 7.425(36.4); 7.285(0.6); 7.261(182.1); 6.997(1.0); 5.299(16.0); 4.231(6.2); 4.224(6.5); 4.151(5.2); 4.136(5.5); 4.118(6.3); 4.103(6.5); 3.810(6.7); 3.788(6.8); 3.777(5.7); 3.755(5.8); 2.414(0.8); 2.407(0.9); 2.399(1.5); 2.392(2.4); 2.385(1.9); 2.372(3.1); 2.360(2.1); 2.353(2.9); 2.347(1.5); 2.339(1.0); 2.333(1.0); 2.093(3.2); 2.075(2.0); 2.063(3.1); 2.043(2.0); 1.821(2.5); 1.801(1.9); 1.788(5.2); 1.755(5.8); 1.749(7.0); 1.735(2.8); 1.727(3.9); 1.720(4.7); 1.713(2.7); 1.688(1.2); 1.682(1.0); 1.569(5.5); 1.549(12.5); 1.542(13.2); 1.533(9.0); 1.521(6.7); 1.512(5.9); 1.391(0.6); 1.359(1.1); 1.333(2.2); 1.324(2.2); 1.304(2.4); 1.293(2.2); 1.284(2.5); 1.276(2.1); 1.256(8.4); 0.897(0.7); 0.880(1.6); 0.863(0.8); 0.008(2.1); 0.000(65.8); 0.008(2.2) Example I-172: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.639(1.4); 7.518(2.5); 7.362(11.2); 7.296(0.6); 7.285(0.6); 7.283(0.5); 7.281(0.5); 7.279(0.6); 7.279(0.7); 7.278(0.8); 7.277(0.8); 7.276(0.8); 7.275(0.9); 7.275(0.9); 7.274(1.1); 7.273(1.2); 7.272(1.4); 7.271(1.4); 7.271(1.6); 7.270(1.8); 7.269(2.0); 7.268(2.4); 7.267(2.9); 7.267(3.6); 7.266(4.4); 7.265(5.4); 7.259(440.8); 7.250(2.9); 7.247(1.2); 7.246(0.9); 7.246(0.7); 7.245(0.8); 7.243(0.6); 7.242(0.6); 6.995(2.5); 4.233(1.7); 4.131(1.5); 4.117(1.4); 4.098(1.7); 4.083(1.7); 3.791(1.8); 3.770(1.8); 3.758(1.6); 3.736(1.8); 2.702(1.5); 2.685(1.6); 2.389(0.7); 2.368(0.8); 2.351(0.6); 2.085(0.8); 2.056(0.8); 2.043(0.6); 1.811(0.8); 1.783(1.3); 1.751(1.4); 1.746(1.7); 1.714(1.1); 1.562(1.3); 1.532(92.6); 1.516(1.6); 1.508(1.2); 1.301(8.0); 1.282(16.0); 1.264(7.8); 0.882(0.8); 0.146(0.5); 0.008(4.9); 0.006(2.0); 0.000(169.3); 0.007(3.2); 0.008(5.7) Example I-173: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.638(1.2); 7.518(3.1); 7.362(11.2); 7.292(0.5); 7.283(0.6); 7.277(1.0); 7.272(1.6); 7.271(1.8); 7.271(2.0); 7.270(2.2); 7.269(2.3); 7.268(2.7); 7.259(545.3); 7.246(0.7); 7.246(0.7); 7.245(0.6); 7.243(0.5); 7.238(0.5); 6.995(3.2); 4.233(1.6); 4.132(1.4); 4.117(1.4); 4.098(1.7); 4.084(1.7); 3.791(1.8); 3.770(1.8); 3.758(1.6); 3.736(1.5); 2.702(1.5); 2.683(1.5); 2.388(0.6); 2.368(0.7); 2.351(0.6); 2.082(0.8); 2.056(0.7); 2.044(0.8); 1.810(0.8); 1.784(1.3); 1.746(1.7); 1.714(1.1); 1.562(1.2); 1.532(126.2); 1.516(1.6); 1.507(1.3); 1.301(8.0); 1.283(16.0); 1.264(7.8); 0.882(1.0); 0.146(0.7); 0.008(6.0); 0.000(210.6); 0.008(6.8); 0.150(0.7) Example I-174: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.674(1.8); 7.519(1.8); 7.457(2.0); 7.439(2.2); 7.435(2.5); 7.415(2.5); 7.410(2.3); 7.393(2.0); 7.386(0.8); 7.302(6.1); 7.300(6.5); 7.287(6.6); 7.285(6.4); 7.260(314.3); 7.030(2.2); 7.014(2.3); 7.006(4.0); 6.996(2.3); 6.990(4.1); 6.982(2.4); 6.967(2.1); 5.298(1.4); 5.151(1.0); 5.128(16.0); 2.089(0.9); 1.542(3.9); 1.332(0.8); 1.284(1.2); 1.256(5.1); 0.880(0.9); 0.008(3.2); 0.000(112.2); 0.008(3.7) Example I-175: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.007(0.9); 7.519(0.6); 7.445(0.8); 7.428(0.9); 7.424(1.0); 7.420(1.0); 7.406(1.0); 7.403(1.0); 7.399(0.9); 7.382(0.8); 7.260(109.6); 7.234(2.8); 7.232(2.8); 7.220(2.9); 7.217(2.8); 7.020(1.0); 7.004(1.0); 6.996(2.3); 6.980(1.7); 6.972(1.0); 6.956(0.9); 5.298(1.7); 5.116(7.1); 2.685(1.0); 1.543(19.1); 1.284(7.8); 1.270(1.0); 1.265(16.0); 1.246(7.4); 0.008(1.2); 0.000(38.9); 0.008(1.1) Example I-176: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.47-7.44 (1H), 7.21 (1H), 7.01-6.98 (1H), 5.12 (2H), 2.75-2.05 (4H), 1.13 (6H) Example I-177: .sup.1H-NMR(400.0 MHz, CDCl3): = 9.457(8.9); 7.519(5.9); 7.425(86.8); 7.309(1.4); 7.285(2.9); 7.260(1064.6); 6.996(5.6); 5.298(10.6); 4.231(13.4); 4.224(14.5); 4.152(12.2); 4.137(13.0); 4.118(15.7); 4.104(15.8); 3.810(15.4); 3.788(16.0); 3.776(13.0); 3.755(13.4); 3.012(1.7); 2.955(3.4); 2.940(1.2); 2.883(2.8); 2.414(1.9); 2.408(2.0); 2.393(5.3); 2.374(6.3); 2.354(5.7); 2.332(2.3); 2.092(6.7); 2.081 (4.8); 2.063(7.0); 1.823(5.7); 1.788(11.3); 1.755(12.5); 1.750(14.8); 1.735(5.7); 1.720(10.1); 1.713(5.6); 1.688(2.8); 1.569(11.3); 1.561(10.2); 1.537(132.8); 1.521(14.6); 1.513(12.4); 1.333(3.9); 1.317(4.1); 1.294(4.1); 1.282(3.9); 1.255(8.7); 0.146(1.3); 0.008(11.6); 0.000(373.9); 0.008(11.2); 0.150(1.3) Example I-178: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO): = 7.720(0.8); 7.702(14.9); 7.686(15.2); 6.627(16.0); 4.478(5.8); 4.471(6.1); 3.992(4.0); 3.973(4.0); 3.959(5.2); 3.940(5.5); 3.808(5.7); 3.792(5.8); 3.775(4.1); 3.759(4.3); 3.605(1.7); 3.362(0.5); 3.354(0.6); 3.344(2.0); 3.311(676.7); 3.270(0.8); 3.261(1.0); 2.679(1.3); 2.674(2.8); 2.670(3.8); 2.665(2.8); 2.523(14.9); 2.518(20.8); 2.510(219.8); 2.505(456.9); 2.501(629.5); 2.496(433.2); 2.492(196.9); 2.451(1.7); 2.337(1.4); 2.332(2.8); 2.327(3.9); 2.323(3.0); 2.318(1.5); 2.276(2.4); 2.072(0.9); 1.988(0.8); 1.947(2.0); 1.915(3.1); 1.822(1.3); 1.812(1.7); 1.804(1.4); 1.790(2.0); 1.784(2.9); 1.755(1.5); 1.748(1.7); 1.738(1.1); 1.684(2.3); 1.653(3.5); 1.630(2.0); 1.620(2.5); 1.597(2.0); 1.588(2.9); 1.564(0.9); 1.556(1.2); 1.495(3.3); 1.462(2.2); 1.429(1.8); 1.399(4.9); 1.391(6.2); 1.375(5.2); 1.367(4.5); 1.271(0.9); 1.258(1.2); 1.240(2.2); 1.229(2.4); 1.217(1.6); 1.199(1.8); 1.157(0.6); 0.008(2.7); 0.000(88.7); 0.008(2.6) Example I-179: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.261(33.2); 6.883(5.2); 5.982(0.7); 5.979(2.2); 5.976(2.2); 5.972(0.8); 5.299(3.0); 4.802(1.3); 3.841(2.5); 3.823(2.6); 3.786(16.0); 2.535(8.6); 2.532(8.8); 1.756(0.5); 1.750(0.5); 1.725(0.8); 1.716(0.9); 1.702(0.9); 1.693(0.8); 1.671(1.1); 1.254(0.6); 1.244(0.7); 1.212(1.0); 1.192(0.7); 1.040(0.7); 1.010(0.6); 0.000(12.4) Example I-180: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.765(2.0); 7.519(1.2); 7.452(1.8); 7.435(2.3); 7.430(2.5); 7.427(2.4); 7.413(2.4); 7.410(2.5); 7.406(2.2); 7.388(2.2); 7.297(5.8); 7.295(6.4); 7.283(6.2); 7.280(6.3); 7.272(1.4); 7.270(1.3); 7.267(1.8); 7.260(201.5); 7.250(0.6); 7.028(2.0); 7.012(2.4); 7.004(3.9); 6.996(1.7); 6.988(3.9); 6.980(2.2); 6.964(2.0); 5.299(3.0); 5.150(1.4); 5.128(16.0); 2.043(1.1); 1.546(6.9); 1.332(0.6); 1.291(0.7); 1.284(1.1); 1.256(5.9); 1.241(0.6); 0.880(1.0); 0.008(2.1); 0.006(0.9); 0.005(1.0); 0.000(73.9); 0.008(2.3) Example I-181: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.085(1.1); 7.520(2.0); 7.286(1.2); 7.283(0.8); 7.261(386.3); 7.230(39.2); 7.216(39.3); 6.997(2.1); 5.299(3.2); 5.106(12.3); 4.677(1.1); 4.265(12.8); 4.258(13.4); 4.114(10.8); 4.099(11.1); 4.080(12.6); 4.066(12.8); 3.713(15.6); 3.691(16.0); 3.680(13.4); 3.658(13.8); 2.428(1.8); 2.422(2.0); 2.414(2.7); 2.408(5.2); 2.401(4.1); 2.393(4.6); 2.387(5.8); 2.375(3.9); 2.368(5.1); 2.362(3.2); 2.353(2.3); 2.347(1.8); 2.074(6.3); 2.059(4.2); 2.048(6.8); 2.040(4.1); 1.810(7.0); 1.803(6.3); 1.780(10.1); 1.775(10.5); 1.750(12.1); 1.744(14.7); 1.730(6.8); 1.725(7.2); 1.722(7.2); 1.713(9.8); 1.706(6.4); 1.690(1.9); 1.682(3.1); 1.675(2.9); 1.555(14.9); 1.548(12.0); 1.535(25.7); 1.526(21.6); 1.510(7.8); 1.500(6.5); 1.476(1.5); 1.467(1.4); 1.407(6.2); 1.355(2.3); 1.330(4.0); 1.320(4.0); 1.299(4.2); 1.278(3.4); 1.254(9.3); 0.880(1.1); 0.145(0.6); 0.070(0.7); 0.008(4.2); 0.000(136.6); 0.008(4.5) Example I-182: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.085(0.8); 7.520(2.0); 7.299(1.2); 7.294(1.0); 7.261(367.6); 7.245(39.4); 7.230(39.1); 6.997(2.0); 5.299(13.3); 5.211(1.9); 4.678(1.0); 4.432(0.5); 4.262(12.8); 4.256(13.5); 4.120(10.8); 4.106(11.1); 4.087(12.7); 4.073(12.9); 3.721(15.6); 3.700(16.0); 3.688(13.3); 3.666(13.8); 2.428(1.8); 2.421(2.0); 2.414(2.6); 2.407(5.1); 2.400(4.1); 2.386(5.8); 2.375(3.7); 2.367(5.2); 2.361(3.1); 2.353(2.0); 2.347(1.9); 2.127(4.5); 2.116(5.3); 2.088(3.4); 2.079(6.4); 2.060(4.2); 2.049(6.6); 2.041(4.0); 2.006(0.6); 1.811 (6.1); 1.777(9.7); 1.773(9.8); 1.750(11.8); 1.745(14.1); 1.730(5.9); 1.722(7.0); 1.714(9.4); 1.707(5.7); 1.683(2.6); 1.676(2.4); 1.555(13.2); 1.549(11.7); 1.536(25.2); 1.527(21.2); 1.511(9.1); 1.502(6.7); 1.478(1.4); 1.469(1.6); 1.356(2.1); 1.332(4.2); 1.321(3.9); 1.300(4.0); 1.280(3.6); 1.255(7.3); 0.880(1.0); 0.146(0.6); 0.070(0.6); 0.008(3.7); 0.000(130.8); 0.008(4.2); 0.150(0.6) Example I-183: .sup.1H-NMR(400.0 MHz, CDCl3): = 8.805(1.9); 7.519(0.8); 7.361(9.2); 7.346(9.2); 7.260(148.8); 6.996(0.8); 5.299(16.0); 4.246(3.4); 4.239(3.6); 4.148(2.7); 4.133(2.7); 4.114(3.1); 4.100(3.1); 3.754(3.6); 3.732(3.7); 3.720(3.1); 3.699(3.2); 2.389(1.4); 2.382(1.1); 2.373(1.8); 2.367(1.7); 2.358(1.2); 2.351(1.5); 2.336(0.6); 2.085(1.7); 2.067(1.1); 2.058(1.7); 2.043(1.1); 1.822(1.5); 1.813(1.6); 1.785(2.9); 1.779(2.4); 1.753(2.5); 1.747(3.3); 1.733(1.8); 1.728(1.6); 1.720(2.0); 1.714(2.4); 1.707(1.4); 1.682(0.6); 1.676(0.6); 1.592(0.6); 1.566(3.2); 1.544(10.7); 1.534(6.1); 1.520(2.8); 1.512(2.0); 1.358(0.5); 1.332(1.2); 1.316(1.2); 1.302(1.3); 1.292(1.1); 1.284(1.3); 1.276(1.2); 1.257(3.5); 0.880(0.7); 0.008(1.8); 0.000(56.2); 0.008(1.9) Example I-184: .sup.1H-NMR(400.0 MHz, CDCl3): = 7.260(34.3); 7.062(2.6); 7.047(2.6); 3.820(3.6); 3.802(3.6); 2.352(0.6); 1.769(0.7); 1.734(1.6); 1.700(1.5); 1.284(0.7); 1.256(6.2); 1.223(1.3); 1.198(1.0); 1.163(7.8); 1.145(16.0); 1.127(7.3); 1.059(0.9); 1.029(0.7); 0.880(0.9); 0.000(12.7)

B) Formulation Examples

(57) a) A dust is obtained by mixing 10 parts by weight of a compound of the formulae (G1) or (G2) and 90 parts by weight of talc as inert substance and comminuting the mixture in a hammer mill. b) A wettable powder which is readily dispersible in water is obtained by mixing 25 parts by weight of a compound of the formulae (G1) or (G2), 64 parts by weight of kaolin-containing quartz as inert substance, 10 parts by weight of potassium lignosulphonate and 1 part by weight of sodium oleoylmethyltaurate as wetting agent and dispersant, and grinding the mixture in a pinned-disk mill. c) A readily water-dispersible dispersion concentrate is obtained by mixing 20 parts by weight of a compound of the formulae (G1) or (G2) with 6 parts by weight of alkylphenol polyglycol ether (Triton X 207), 3 parts by weight of isotridecanol polyglycol ether (8 EO) and 71 parts by weight of paraffinic mineral oil (boiling range for example about 255 to above 277 C.) and grinding the mixture in a ball mill to a fineness of below 5 microns. d) An emulsifiable concentrate is obtained from 15 parts by weight of a compound of the formulae (G1) or (G2), 75 parts by weight of cyclohexanone as solvent and 10 parts by weight of oxyethylated nonylphenol as emulsifier. e) Water-dispersible granules are obtained by mixing 75 parts by weight of a compound of the formulae (G1) or (G2), 10 parts by weight of calcium lignosulphonate, 5 parts by weight of sodium laurylsulphate, 3 parts by weight of polyvinyl alcohol and 7 parts by weight of kaolin, grinding the mixture in a pinned-disk mill, and granulating the powder in a fluidized bed by spray application of water as a granulating liquid. f) Water-dispersible granules are also obtained by homogenizing and precomminuting 25 parts by weight of a compound of the formulae (G1) or (G2), 5 parts by weight of sodium 2,2-dinaphthylmethane-6,6-disulphonate, 2 parts by weight of sodium oleoylmethyltaurinate, 1 part by weight of polyvinyl alcohol, 17 parts by weight of calcium carbonate and 50 parts by weight of water, on a colloid mill, subsequently grinding the mixture in a bead mill and atomizing and drying the resulting suspension in a spray tower by means of a single-substance nozzle.

(C) Biological Examples

(58) Herbicidal activities of the compounds of the formulae (G1) or (G2) according to the invention were investigated against the following harmful plants: ALOMY=Alopecurus myosuroides ECHCG=Echinochloa crus-galli SETVI=Setaria viridis ABUTH=Abutilon theophrasti AMARE=Amaranthus retroflexus PHBPU=Pharbitis purpurea POLCO=Polygonum convolvulus (=Fallopia convolvulus) STEME=Stellaria media VIOTR=Viola tricolor

(59) Herbicidal Effect and Crop Plant Compatibility Pre-Emergence

(60) Seeds of mono- and dicotyledonous weed plants and crop plants are sown in wood-fiber pots in sandy loam and covered with soil. The compounds according to the invention, formulated in the form of wettable powders (WP) or as emulsifiable concentrates (EC), are then applied to the surface of the covering soil as aqueous suspension or emulsion, with the addition of 0.5% of an additive, at an application rate of 600 l of water/ha (converted).

(61) Following treatment, the pots are placed in a greenhouse and kept under optimum growth conditions for the test plants. The visual grading of the damage to the test plants is carried out after ca. 3 weeks in comparison to untreated controls (herbicidal effect in percent (%): 100% effect=plants have died off, 0% effect=as control plants).

(62) TABLE-US-00006 TABLE 5 Example Number Dosage Unit SETVI AMARE STEME VIOTR ALOMY MATIN I-128 320 g/ha 100 100 100 100 100 100 I-161 320 g/ha 100 100 100 100 100 100 I-156 320 g/ha 100 100 100 100 100 100 I-127 320 g/ha 100 100 100 100 100 100 I-163 320 g/ha 100 100 100 100 100 100 I-172 320 g/ha 100 100 100 100 100 100 I-138 320 g/ha 100 100 100 100 100 90 I-064 320 g/ha 100 100 100 100 100 100 I-086 320 g/ha 100 100 100 100 100 100 I-077 320 g/ha 100 100 100 100 100 90 I-081 320 g/ha 100 100 100 100 100 100 I-078 320 g/ha 100 100 100 100 100 100 I-160 320 g/ha 100 100 100 100 100 100 I-165 320 g/ha 100 100 100 100 100 100 I-136 320 g/ha 100 100 100 100 100 90 I-087 320 g/ha 100 100 100 100 100 90 I-049 320 g/ha 100 100 100 90 80 80 I-048 320 g/ha 100 100 100 100 80 90 I-084 320 g/ha 100 100 100 100 100 100 I-171 320 g/ha 100 100 100 100 100 100 I-088 320 g/ha 100 100 100 100 100 100 I-029 320 g/ha 90 100 90 100 90 90 I-028 320 g/ha 100 90 100 100 90 90 I-083 320 g/ha 100 100 100 100 100 100 I-047 320 g/ha 90 100 100 100 80 90 I-054 320 g/ha 100 100 100 100 90 100

(63) TABLE-US-00007 TABLE 6 Example Number Dosage Unit SETVI AMARE VIOTR I-039 320 g/ha 100 100 100 I-135 320 g/ha 100 100 100 I-085 320 g/ha 100 100 100 I-051 320 g/ha 90 90 100 I-144 320 g/ha 90 100 100 I-035 320 g/ha 100 100 80 I-007 320 g/ha 80 100 90 I-159 320 g/ha 100 100 100 I-082 320 g/ha 100 100 100 I-102 320 g/ha 100 100 100 I-044 320 g/ha 90 100 100 I-173 320 g/ha 100 90 100 I-033 320 g/ha 100 100 100 I-034 320 g/ha 100 100 100 I-036 320 g/ha 90 100 80 I-022 320 g/ha 100 100 100 I-170 320 g/ha 100 100 90 I-155 320 g/ha 100 80 100 I-046 320 g/ha 100 100 90 I-118 320 g/ha 90 90 80 I-056 320 g/ha 90 90 100 I-133 320 g/ha 90 90 100 I-167 320 g/ha 100 100 100 I-107 320 g/ha 80 100 100 I-080 320 g/ha 80 80 100 I-070 320 g/ha 100 100 100 I-027 320 g/ha 90 100 90 I-079 320 g/ha 100 100 100 I-032 320 g/ha 100 80 80 I-023 320 g/ha 90 100 90 I-103 320 g/ha 80 90 100 I-021 320 g/ha 90 100 100 I-105 320 g/ha 100 100 100 I-158 320 g/ha 80 90 100

(64) At the same time, compounds according to the invention leave graminaceous crops such as barley, wheat, rye, millet, corn or rice practically undamaged in the pre-emergence method, even at high dosages of active ingredient. Moreover, some substances also leave dicotyledonous crops such as soybean, cotton, rapeseed, or sugar beet undamaged.

(65) Some of the compounds according to the invention exhibit high selectivity and are therefore suitable pre-emergence for controlling undesired plant growth in agricultural crops.

(66) Herbicidal Effect and Crop Plant Compatibility Post-Emergence

(67) Seeds of mono- and dicotyledonous weed plants and crop plants are sown in wood-fiber pots in sandy loam, covered with soil and grown in a greenhouse under controlled growth conditions. 2 to 3 weeks after sowing, the test plants are sprayed in the single-leaf stage. The compounds according to the invention, formulated in form of wettable powders (WP) or as emulsifiable concentrates (EC), are then sprayed onto the green plant parts as aqueous suspension or emulsion, with the addition of 0.5% of an additive, at an application rate of 600 l of water/ha (converted). After the test plants had been in the greenhouse for ca. 3 weeks under optimum growth conditions, the effect of the preparations is assessed visually in comparison with untreated controls (herbicidal effect in percent (%): 100% effect=plants have died off, 0% effect=as control plants).

(68) TABLE-US-00008 TABLE 7 Example Number Dosage Unit SETVI AMARE STEME VIOTR MATIN PHBPU POLCO I-128 320 g/ha 100 100 100 100 100 100 100 I-160 320 g/ha 100 100 100 100 80 100 100 I-064 320 g/ha 100 100 100 100 100 100 100 I-171 320 g/ha 100 100 100 100 90 100 100 I-161 320 g/ha 100 100 100 100 80 100 100 I-127 320 g/ha 100 100 100 100 100 100 100 I-165 320 g/ha 90 100 100 100 100 80 100 I-136 320 g/ha 90 100 100 100 100 100 100 I-007 320 g/ha 100 100 100 100 100 100 100 I-156 320 g/ha 100 100 100 100 80 100 100

(69) TABLE-US-00009 TABLE 8 Example Number Dosage Unit SETVI AMARE VIOTR ABUTH I-163 320 g/ha 90 100 90 90 I-172 320 g/ha 80 100 100 100 I-083 320 g/ha 100 100 100 80 I-039 320 g/ha 100 100 100 100 I-084 320 g/ha 100 100 100 100

(70) TABLE-US-00010 TABLE 9 Example Number Dosage Unit SETVI AMARE VIOTR I-088 320 g/ha 100 100 100 I-077 320 g/ha 90 100 90 I-102 320 g/ha 100 100 100 I-054 320 g/ha 100 100 100 I-085 320 g/ha 100 100 100 I-086 320 g/ha 100 100 100 I-113 320 g/ha 100 100 100 I-108 320 g/ha 100 100 100 I-138 320 g/ha 80 100 100 I-118 320 g/ha 100 100 100 I-079 320 g/ha 90 100 100 I-082 320 g/ha 100 100 100 I-048 320 g/ha 100 100 100 I-080 320 g/ha 100 100 80 I-070 320 g/ha 100 100 100 I-081 320 g/ha 100 100 100 I-078 320 g/ha 100 100 80 I-044 320 g/ha 100 100 100 I-087 320 g/ha 100 100 100 I-135 320 g/ha 90 100 100 I-042 320 g/ha 90 100 100 I-120 320 g/ha 100 100 100 I-049 320 g/ha 100 90 100 I-036 320 g/ha 100 90 100 I-020 320 g/ha 100 100 100 I-023 320 g/ha 90 100 100 I-072 320 g/ha 80 100 100 I-021 320 g/ha 100 100 80 I-115 320 g/ha 100 100 100 I-142 320 g/ha 100 100 80 I-143 320 g/ha 100 100 100 I-047 320 g/ha 90 90 100 I-103 320 g/ha 100 100 100 I-141 320 g/ha 100 100 100 I-132 320 g/ha 100 80 90 I-147 320 g/ha 80 100 100 I-126 320 g/ha 80 100 100 I-056 320 g/ha 100 90 90 I-134 320 g/ha 80 100 100

(71) At the same time, compounds according to the invention leave graminaceous crops such as barley, wheat, rye, millet, corn or rice practically undamaged in the post-emergence method, even at high dosages of active ingredient. Moreover, some substances also leave dicotyledonous crops such as soybean, cotton, rapeseed, or sugar beet undamaged. Some of the compounds according to the invention exhibit high selectivity and are therefore suitable post-emergence for controlling undesired plant growth in agricultural crops.

Fungicidal Examples

1) Example: In Vivo Preventive Test on Alternaria brassicae (Leaf Spot on Radish or Cabbage)

(72) Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone

(73) Emulsifier: 1 l of Tween 80 per mg of active ingredient

(74) The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

(75) The young plants of radish or cabbage were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

(76) After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Alternaria brassicae spores. The contaminated radish or cabbage plants were incubated for 6 days at 20 C. and at 100% relative humidity.

(77) The test was evaluated 6 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

(78) In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: I-020; I-027; I-028; I-034; I-108

2) Example: In Vivo Preventive Test on Botrytis cinerea (Grey Mould)

(79) Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone

(80) Emulsifier: 1 l of Tween 80 per mg of active ingredient

(81) The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

(82) The young plants of gherkin were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

(83) After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Botrytis cinerea spores. The contaminated gherkin plants were incubated for 4 to 5 days at 17 C. and at 90% relative humidity.

(84) The test was evaluated 4 to 5 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

(85) In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: I-030; I-032; I-056; I-115; I-128; I-136; I-138; I-141; I-143; I-147; I-155; I-166; I-168; I-169

(86) In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: I-028; I-113; I-167

3) Example: In Vivo Preventive Test on Phytophthora infestans (Tomato Late Blight)

(87) Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone

(88) Emulsifier: 1 l of Tween 80 per mg of active ingredient

(89) The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

(90) The young plants of tomato were treated by spraying the active ingredient prepared as described above.

(91) Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

(92) After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Phytophthora infestans spores. The contaminated tomato plants were incubated for 5 days at 16-18 C. and at 100% relative humidity.

(93) The test was evaluated 5 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

(94) In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: i-009; I-016; I-017; I-018; I-020; I-023; I-025; I-027; I-029; I-032; I-034; I-035; I-036; I-037; I-038; I-041; I-042; I-043; I-047; I-049; I-050; I-056; I-063; I-067; I-068; I-069; I-070; I-072; I-090; I-103; I-104; I-105; I-108; I-112; I-114; I-115; I-119; I-122; I-125; I-130; I-131; I-132; I-134; I-138; I-141; I-143; I-146; I-147; I-155; I-159

(95) In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: I-028; I-077; I-080; I-081; I-113; I-118; I-120; I-123; I-133; I-136

4) Example: In Vivo Preventive Test on Puccinia recondita (Brown Rust on Wheat)

(96) Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone

(97) Emulsifier: 1 l of Tween 80 per mg of active ingredient

(98) The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

(99) The young plants of wheat were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

(100) After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Puccinia recondita spores. The contaminated wheat plants were incubated for 24 hours at 20 C. and at 100% relative humidity and then for 10 days at 20 C. and at 70-80% relative humidity.

(101) The test was evaluated 11 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

(102) In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: I-069; I-070; I-080; I-081; I-088; I-090; I-103; I-105; I-108; I-113; I-118; I-120; I-123; I-125; I-130; I-132; I-133; I-141; I-143; I-147; I-155; I-158; I-159; I-168

(103) In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: I-054; I-064; I-077; I-078; I-083; I-085; I-086; I-087; I-156; I-160; I-163; I-182

5) Example: In Vivo Preventive Test on Septoria tritici (Leaf Spot on Wheat)

(104) Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone

(105) Emulsifier: 1 l of Tween 80 per mg of active ingredient

(106) The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

(107) The young plants of wheat were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

(108) After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Septoria tritici spores. The contaminated wheat plants were incubated for 72 hours at 18 C. and at 100% relative humidity and then for 21 days at 20 C. and at 90% relative humidity.

(109) The test was evaluated 24 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

(110) In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: I-016; I-017; I-020; I-021; I-022; I-023; I-027; I-028; I-029; I-032; I-034; I-035; I-070; I-073; I-081; I-090; I-106; I-118; I-119; I-120; I-122; I-123; I-130; I-131; I-132; I-133; I-163

(111) In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: I-025; I-042; I-072; I-077; I-078; I-086; I-102; I-103; I-105; I-115; I-136; I-147; I-155

6) Example: In Vivo Preventive Test on Sphaerotheca fuliginea (Powdery Mildew on Cucurbits)

(112) Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone

(113) Emulsifier: 1 l of Tween 80 per mg of active ingredient

(114) The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

(115) The young plants of gherkin were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

(116) After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Sphaerotheca fuliginea spores. The contaminated gherkin plants were incubated for 72 hours at 18 C. and at 100% relative humidity and then for 12 days at 20 C. and at 70-80% relative humidity.

(117) The test was evaluated 15 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

(118) In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: I-080; I-104; I-108; I-113; I-119; I-130; I-133; I-134; I-141; I-157; I-166; I-169

(119) In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: I-028; I-077; I-086; I-088; I-105; I-118; I-120; I-168

Insecticidal Examples

(120) 1) Meloidogyne incognitaTest

(121) Solvent: 125.0 parts by weight of acetone

(122) To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvent, and the concentrate is diluted with water to the desired concentration.

(123) Vessels are filled with sand, a solution of the active ingredient, a suspension containing eggs and larvae of the southern root-knot nematode (Meloidogyne incognita) and salad seeds. The salad seeds germinate and the seedlings grow. Galls develop in the roots.

(124) After 14 days the nematicidal activity is determined on the basis of the percentage of gall formation. 100% means no galls were found and 0% means the number of galls found on the roots of the treated plants was equal to that in untreated control plants.

(125) In this test, for example, the following compounds from the preparation examples showed good activity of 90% at an application rate of 20 ppm: 1-038, I-042, I-049, I1-050

(126) 2) Myzus persicaeSpray Test

(127) Solvent: 78.0 parts by weight acetone 1.5 parts by weight dimethylformamide

(128) Emulsifier: alkylarylpolyglycol ether

(129) To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvents and is diluted with water, containing an emulsifier concentration of 1000 ppm, to the desired concentration. Further test concentrations are prepared by dilution with emulsifier containing water.

(130) Chinese cabbage (Brassica pekinensis) leaf disks infected with all instars of the green peach aphid (Myzus persicae), are sprayed with a preparation of the active ingredient of the desired concentration.

(131) After 5 days mortality in % is determined. 100% means all aphids have been killed and 0% means none of the aphids have been killed.

(132) In this test, for example, the following compounds from the preparation examples showed good activity of 100% at an application rate of 500 g/ha: I-043, I-077, I-081, I-083, I-084, I-086, I-088

(133) In this test, for example, the following compounds from the preparation examples showed good activity of 90% at an application rate of 500 g/ha: I-007, I-037, I-042, I-049, I-072, I-080, I-103

(134) 3) Nezara viridulaSpray Test

(135) Solvent: 78.0 parts by weight of acetone 1.5 parts by weight of dimethylformamide

(136) Emulsifier: alkylarylpolyglycol ether

(137) To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvent, and the concentrate is diluted with water, containing an emulsifier concentration of 1000 ppm, to the desired concentration. Further test concentrations are prepared by dilution with emulsifier containing water.

(138) Barley plants (Hordeum vulgare) infested with larvae of the southern green stink bug (Nezara viridula) are sprayed with a test solution containing the desired concentration of the active ingredient.

(139) After 4 days mortality in % is determined. 100% means all the stink bugs have been killed; 0% means none of the stink bugs have been killed.

(140) In this test, for example, the following compounds from the preparation examples showed good activity of 90% at an application rate of 500 g/ha: I-078, I-087, I-102

(141) 4) Nilaparvata lugensSpray Test

(142) Solvent: 78.0 parts by weight of acetone 1.5 parts by weight of dimethylformamide

(143) Emulsifier: alkylarylpolyglycol ether

(144) To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvents and is diluted with water, containing an emulsifier concentration of 1000 ppm, to the desired concentration. Further test concentrations are prepared by dilution with emulsifier containing water.

(145) Rice plants (Oryza sativa) are sprayed with a preparation of the active ingredient of the desired concentration and the plants are infested with the brown planthopper (Nilaparvata lugens).

(146) After 4 days mortality in % is determined. 100% means all planthoppers have been killed and 0% means none of the planthoppers have been killed.

(147) In this test, for example, the following compounds from the preparation examples showed good activity of 100% at an application rate of 500 g/ha: 1-007, I1-087

(148) 5) Phaedon cochleariaeSpray Test

(149) Solvent: 78.0 parts by weight of acetone 1.5 parts by weight of dimethylformamide

(150) Emulsifier: alkylarylpolyglycol ether

(151) To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvents and is diluted with water, containing an emulsifier concentration of 1000 ppm, to the desired concentration. Further test concentrations are prepared by dilution with emulsifier containing water.

(152) Chinese cabbage (Brassica pekinensis) leaf disks are sprayed with a preparation of the active ingredient of the desired concentration. Once dry, the leaf disks are infested with mustard beetle larvae (Phaedon cochleariae).

(153) After 7 days mortality in % is determined. 100% means all beetle larvae have been killed and 0% means none of the beetle larvae have been killed.

(154) In this test, for example, the following compounds from the preparation examples showed good activity of 83% at an application rate of 500 g/ha: I-084

(155) 6) Spodoptera frugiperdaSpray Test

(156) Solvent: 78.0 parts by weight acetone 1.5 parts by weight dimethylformamide

(157) Emulsifier: alkylarylpolyglycol ether

(158) To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvents and is diluted with water, containing an emulsifier concentration of 1000 ppm, to the desired concentration. Further test concentrations are prepared by dilution with emulsifier containing water.

(159) Maize (Zea mays) leaf sections are sprayed with a preparation of the active ingredient of the desired concentration. Once dry, the leaf sections are infested with fall armyworm larvae (Spodoptera frugiperda).

(160) After 7 days mortality in % is determined. 100% means all caterpillars have been killed and 0% means none of the caterpillars have been killed.

(161) In this test, for example, the following compounds from the preparation examples showed good activity of 100% at an application rate of 500 g/ha: I-007, I-037, I-047, I-049, I-070, I-077, I-078, I-081, I-083, I-084, I-085, I-086, I-087, I-088, I-102

(162) 7) Tetranychus urticaeSpray Test OP-Resistant

(163) Solvent: 78.0 parts by weight acetone 1.5 parts by weight dimethylformamide

(164) Emulsifier: alkylarylpolyglycol ether

(165) To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvents and is diluted with water, containing an emulsifier concentration of 1000 ppm, to the desired concentration. Further test concentrations are prepared by dilution with emulsifier containing water.

(166) French bean (Phaseolus vulgaris) leaf disks infected with all instars of the two spotted spidermite (Tetranychus urticae), are sprayed with a preparation of the active ingredient of the desired concentration.

(167) After 6 days mortality in % is determined. 100% means all spider mites have been killed and 0% means none of the spider mites have been killed.

(168) In this test, for example, the following compounds from the preparation examples showed good activity of 100% at an application rate of 500 g/ha: I-047, I-078, I-085, I-087

(169) In this test, for example, the following compounds from the preparation examples showed good activity of 95% at an application rate of 500 g/ha: I-086, I-088

(170) In this test, for example, the following compounds from the preparation examples showed good activity of 90% at an application rate of 500 g/ha: I-043, I-072, I-077, I-081, I-083, I-084