Composition and method of treating actinic purpura

Abstract

The present invention is a composition and method of treatment for actinic purpura, skin disorders, and skin conditions in general through topical systematic and periodic application of a formulation that generally may include ingredients to improve circulation such as but not limited to arnica oil CLR and phytotonine; ingredients to thicken the skin such as but not limited to retistar, glycolic acid, vitamin K1, and phyto-age; and ingredients to repair the skin's barrier, such as but not limited to timecode, SKINMIMICS, ABS pomegranate sterols, and pentatavitin.

Claims

1. A composition for the treatment of actinic purpura comprising: Arnica montana flower extract, Glycine soja oil, tocopherol, propylene glycol, Cupressus sempervirens seed extract, Polygonatum, multiflorum extract, caprylic/capric triglyceride, sodium ascorbate, retinol, glycolic acid, phytonadione, Cimicifuga racemose root extract, ceteareth-25, glycerin, cetyl alcohol, behenic acid, cholesterol, ceramide NP, ceramide NS, ceramide EOS, ceramide AP, caprooyl phytosphingosine, caprooyl sphingosine, Punica granatum sterols, saccharide isomerate, butylene glycol, pentylene glycol, hydroxyphenyl propamidobenzoic acid and niacinamide; and wherein the ingredients are in amounts effective to treat said actinic purpura.

Description

DETAILED DESCRIPTION

(1) In a preferred embodiment, the present invention is a composition and method of treatment for actinic purpura, skin disorders, and skin conditions in general through topical systematic and periodic application of a formulation that generally may include ingredients to improve circulation such as but not limited to arnica oil CLR and phytotonine; ingredients to thicken the skin such as but not limited to retistar, glycolic acid, vitamin K1, and phyto-age; and ingredients to repair the skin's barrier, such as but not limited to timecode, SKINMIMICS, ABS pomegranate sterols, and pentatavitin. The formulation may be utilized as a cream, lotion, liquid, gel, and combinations thereof and may be utilized as a moisturizer in treating the symptoms associated with solar and or actinic purpura. It is also contemplated that the current invention may be used as a mainstay in the treatment and continued maintenance of the symptoms associated with solar and or actinic purpura as well as a part of a successful treatment regimen specifically formulated for hyperkeratotic skin conditions. It is also understood that the following description of said components is not limited to exact percentages, quantities, or ingredients and that it is understood equivalent ingredients known in the art may be substituted or added.

(2) It is understood that the current invention contemplates use of arnica oil which is generally made from Arnica montana, known commonly as leopard's bane, wolf s bane, mountain tobacco and mountain arnica. It is a European flowering plant with large yellow capitula. Arnica is a genus with about 30 perennial, herbaceous species, belonging to the sunflower family Asteraceae). The genus name Arnica may be derived from the Greek arna, lamb, in reference to the soft, hairy leaves.

(3) This circumboreal and montane (subalpine) genus occurs mostly in the temperate regions of western North America, while two are native to Eurasia (A. angustifolia and A. montana).

(4) The current invention contemplates the utilization of and may utilize the brand of arnica oil made by CLR NORTH AMERICA also referred to as arnica oil CLR although it is understood that other brands, types, and arnica sources are contemplated. Arnica oil CLR May combine Glycine soja (Soybena) Oil (and) Arnica montana Flower Extract (and) Tocopherol. Generally, arnica Oil CLR is a fatty oil extract from arnica blossoms.

(5) In a preferred embodiment, the current invention will utilize the benefits of the combination of arnica oil, glycolic acid, and retinol. The formulation may include ingredients to help improve microcirculation and strengthen blood vessels, boost production of collagen, elastin, and other proteins associated with skin firmness, and protect the connective tissue from degradation. Furthermore, the current invention may provide a cosmetically pleasing feature with coloring to match the skin tone of non-bruised skin while covering bruised areas. The invention may be applied only once or twice per day depending on the severity of symptoms.

(6) The current invention contemplates a cream, gel, lotion, liquid and combinations thereof of a formulation that may include ingredients to help improve microcirculation and strengthen blood vessels, boost production of collagen, elastin, and other proteins associated with skin firmness, and protect the connective tissue from degradation. It is also contemplated to utilize the formulation with sunscreen. In a preferred embodiment, to prevent further ultraviolet-induced damage to the skin, sunscreens that provide both UV-A and UV-B protection may be applied daily, especially to areas affected by the purpuric lesions. The use of tretinoin may be beneficial in actinic purpura because photo damage is ultimately responsible for this disorder. Tretinoin increases the amount of dermal collagen and decreases the amount of abnormal elastin when applied topically.

(7) The current invention contemplates ingredients to improve circulation such as but not limited to arnica oil CLR and phytotonine; ingredients to thicken the skin such as but not limited to retistar, glycolic acid, vitamin K1, and phyto-age; and ingredients to repair the skin's barrier, such as but not limited to timecode, SKINMIMICS, ABS pomegranate sterols, and pentatavitin.

(8) The current invention contemplates a formulation as follows in TABLE 1. It is understood the current invention is not limited to same and the below is for illustrative purposes.

(9) TABLE-US-00001 TABLE 1 CONCENTRATION TRADE NAME INCI NAME (W/W) FUNCTION Miscellaneous QS to 100% Purified water, thickener, emollients, preservative, fragrance, pH adjuster, etc. Arnica Oil CLR Glycine Soja (Soybean) 1% Arnica extract has a favorable effect on Oil (and) Arnica blood flow of peripheral vessels, as Montana Flower Extract well as anti-inflammatory action. It is (and) Tocopherol commonly used to help minimize/prevent bruising. Phytotonine Propylene Glycol (and) 3% Plant extracts of Arnica, Cypress, and Arnica Montana Flower Solomon's Seal that help to improve Extract (and) Cupressus microcirculation and Sempervirens Seed strengthen/reinforce vein walls Extract (and) Polygonatum Multiflorum Extract Retistar Caprylic/Capric 1% A stabilized oily dispersion of retinot Triglyceride (and) that provides protection against Sodium Ascorbate (and) photoaging, improves epithelization, Tocopherol (and) normalizes the physiology of the Retinot epidermis, and improves skin pigmentation and barrier function Glycolic Acid Glycolic Acid 4% Continued use promotes skin thickening via stimulating collagen production Vitamin K1 Phytonadione 0.001% Promotes healing of skin discoloration, vascular problems, and scars Phyto-Age Cimicifuga Racemosa 0.05% Chinese plant extract that helps Root Extract redensify the dermis via synthesis of laminin, Type 1 collagen, and GAGS. Its hormone-like activity compensates for decline in estrogen production. Timecode Palmitoyl Glycine 1% Redensifying and anti-inflammatory; promotes microcirculation and improves cellular metabolism SKINMIMICS Ceteareth-25 (and) 2% Barrier repair and overall water Glycerin (and) Cetyl management for mature skin Alcohol (and) Behenic Acid (and) Cholesterol (and) Ceramide NP (and) Ceramide NS (and) Ceramide EOS (and) Ceramide EOP (and) Ceramide AP (and) Caprooyl Phytosphingosine (and) Caprooyl Sphingosine ABS Punica Granatum 1% Barrier repair and water absorption Pomegranate Sterols Sterols Pentavitin Saccharide Isomerate 3% Humectant; substantive and durable hydrating effect; effective in low humidity environments and combating irritation associated with AHA use. SymCalmin Butylene Glycol (and) 1% Anti-itch and anti-redness Pentylene Glycol (and) Hydroxyphenyl Propamidobenzoic Acid Niacinamide Niacinamide 0.5% Anti-oxidant, anti-inflammatory, and barrier repair

(10) Still further, the current invention contemplates a formulation as follows in TABLE 2. It is understood the current invention is not limited to same and the below is for illustrative purposes.

(11) TABLE-US-00002 TABLE 2 CTFA NAME TRADE NAME % (W/W) Purified Water Purified Water, USP 69.849 Cetearyl Alcohol (and) Montanov 82 1.500 Coco-Glucosides Glycine Soja (Soybean) Oil Arnica Oil CLR 1.000 (and) Arnica Montana Flower Extract (and) Tocopherol Propylene Glycol (and) Arnica Phytotonine 3.000 Flower Montana Flower Extract (and) Cupressus Sempervirens Seed Extract (and) Polygonatum Multiflorum Extract Glycolic Acid (and) Ammonium Glycolic 4.000 Glycolate Compound 4.4 Cimicifuga Racemosa Root Extract Phyto-Age 0.050 Palmitoyl Glycine Timecode 1.000 Ceteareth-25 (and) Glycerin (and) SKINMIMICS 2.000 Cetyl Alcohol (and) Behenic Acid (and) Cholesterol (and) Ceramide NP (and) Ceramide NS (and) Ceramide EOS (and) Ceramide EOP (and) Ceramide AP (and) Caprooyl Phytosphingosine (and) Caprooyl Sphingosine Saccharide Isomerate Pentavitin 3.000 Butylene Glycol (and) Pentylene SymCalmin 1.000 Glycol (and) Hydroxyphenyl Propamidobenzoic Acid Niacinamide Niacinamide USP 0.500 Glycerin Glycerin 99.7% 1.000 USP Kosher Disodium EDTA Versene NA 0.100 Hydroxyethyl acrylate/sodium Sepinov EMT 10 2.000 acryloyldimethyl taurate copolymers Stearyl Alcohol Stearyl Alcohol 1.000 Punica Granatum ABS Pomegranate 1.000 (Pomegranate) Sterols Sterols Caprylic/Capric Triglyceride Neobee M5 1.500 Phytonadione Vitamin K1 0.001 Tocopheryl Acetate Vitamin E Acetate 0.200 Polysorbate 20 (and) Retinol Retinol 50 C 0.100 Ethylhexylglycerin (and) Euxyl PE 9010 1.000 Phenoxyethanol Propanediol Zemea 3.000 Propanediol C/PC Fluorphlogopite (and) Chione Snowfall 0.200 Titanium Dioxide White Polyacrylamide (and) C13-14 Sepigel 305 2.000 Isoparaffin (and) Laureth-7

(12) The mode of action of the Arnica Oil CLR is described as having a favorable effect on the blood flow in peripheral vessels, an anti-inflammatory effect and also a granulating and epithelizing effect on the tissue. Increased circulation and reduced venous congestion are due to the inhibiting effect on aggregation of thrombocytes (3) which is produced by the sesquiterpene lactone contained in arnica extracts. The same actives cause the anti-inflammatory effect by inhibiting inflammatory cytokines. But also, polysaccharides contained in arnica extracts have a modulatory effect on the immune system because they increase phagocytosis and stimulate macrophages.

(13) Herbal active agents have great significance also in pharmacological research. It has been recognized that neither synthesized herbal ingredients nor active substances isolated from plants are equivalent to total complexes extracted from herbs. Synthesis or isolation cannot encompass the multitude of natural accompanying substances that have synergistic properties. The presence of these naturally accompanying substances is what makes effectiveness of complex plant extracts so superior to that of synthesized or isolated individual substances. Arnica Oil CLR is a carefully prepared herbal extract, which contains the lipophilic, active constituents of arnica blossoms in conjunction with synergistic accompanying substances, thus representing a total herbal complex.

(14) SKINMIMICS has proven in-vivo benefits in dry mature skin. It revitalizes dry mature skin by optimizing the total epidermal water management system, repairs the skin's own water protection barrier, activates the skin's own water natural moisturizing system (sphingolipids, filaggrin), and increases the glycerol and water transport mechanism (aquaporin-3). It also contains the recently identified cell-signaling Sphingokine molecules. SKINMIMICS was designed to provide mature skin with three important aspects of skin treatment. Those being protection by correction and repair of membrane defects of the stratum corneum lipid barrier, prevention by supplementation of skin's own precursor substances to finally activate the skin lipid synthesis, and regeneration by stimulation of epidermal renewal and repair (filaggrin, aquaporin 3).

(15) It is a unique multi-lamellar concentrate based on advanced Ceramide technology and the newly identified SPHINGOKINES. SKINMIMICS is a skin-identical equimolar blend of new and unique long chain Ceramides (including Ceramide EOP, EOS, NS, NP and AP) with a broad distribution of fatty acid side-chains, new vegetal based cholesterol and behenic acid. These three types of lipids, essential for protection benefits, are combined with the unique SPHINGOKINES, signaling molecules playing a key role in the prevention and regeneration attributes of SKINMIMICS.

(16) A number of implementations have been described herein. Nevertheless, it will be understood that various modifications may be made. Accordingly, other implementations are within the scope of the following claims. Changes may be made in the combinations, operations, and arrangements of the various parts, elements, and amounts described herein without departing from the spirit and scope of the invention.