METHOD FOR THE AUTOMATED PRODUCTION OF INDIVIDUALIZED TABLETS, AND TABLET PRESS FOR THE AUTOMATED PRODUCTION OF INDIVIDUALIZED TABLETS

Abstract

A method for producing tablets with an active substance including inputting a target number of tablets to produce and a target mass indicating the quantity of active substance per tablet, transmitting the target number and target mass to a controller configured to control a dosing device, a weighing device, extendable upper and lower punches, filling a quantity of the active substance from a container into an opening of a die. While filling, a pressure face of the lower punch closes the opening, and the amount of the active substance is measured by the weighing device on which the lower punch and the die are placed while filling. The method further including pressing the active substance, releasing a pressed tablet from the die, and repeating the repeating the process until the target number is reached.

Claims

1. A method for automatically producing a number of individualized tablets with a first quantity of a first active substance by a tablet press, the method comprising: inputting a target number which indicates the number of tablets to be produced and a first target mass which indicates the quantity of the first active substance per tablet, transmitting the target number and the first target mass to a controller of the tablet press, wherein the controller is configured to control a first dosing device, a weighing device, an extendable upper punch, and an extendable lower punch, filling a quantity of the first active substance which corresponds to the first target mass from a first material container into a central opening of a die by the first dosing device, wherein while filling, a pressure face of the lower punch closes the central opening on one side, and the amount of the first active substance filled into the central opening is measured by the weighing device on which the lower punch and the die are placed while filling, pressing the first active substance by extending a pressure face of the upper punch into the central opening, releasing a pressed tablet from the die by extending the pressure face of the lower punch into the central opening, and repeating the filling of the quantity of the first active substance, pressing of the first active substance, and releasing of the pressed tablet until a number of pressed tablets corresponds to the target number.

2. The method according to claim 1, wherein the outer circumference of the pressure face of the upper punch for pressing the first active substance is adapted to the inner circumference of the die in that a number of vertically telescoping upper punch shafts of the upper punch arranged inside each other are extended downwards, wherein the outer circumference of the outer extended upper punch shaft corresponds to the inner circumference of the die.

3. The method according to claim 1, wherein the outer circumference of the pressure face of the lower punch is adapted to the inner circumference of the die before the filling of the quantity of the first active substance in that a number of vertically telescoping lower punch shafts of the lower punch arranged inside each other are extended upwards, wherein the outer circumference of the outer extended lower punch shaft corresponds to the inner circumference of the die.

4. The method according to claim 1, wherein a mass of the first active substance filled into the central opening is measured by placing the die and the lower punch on the weighing device before filling wherein the weighing device measures the total mass acting on it while filling, which comprises the mass of the die, the mass of the lower punch, and the mass of the first active substance filled into the central opening, wherein the die and the lower punch are lifted after filling and before pressing the first active substance.

5. The method according to claim 4, wherein the die and the lower punch are placed on the weighing device before filling by at least one lifting device, and the die and the lower punch are lifted after filling and before pressing the first active substance by the at least one lifting device.

6. The method according to claim 5, wherein the pressure acting on one or more of the lower punch and the upper punch is measured at the at least one lifting device.

7. The method according to claim 6, wherein the pressure is measured by a pressure measuring device.

8. The method according to claim 1, wherein the first dosing device is arranged vertically above the central opening by a positioning device before adding the quantity of the first active substance, wherein the upper punch is arranged vertically above the central opening by the positioning device after adding the quantity of the first active substance and before pressing the first active substance, wherein the first dosing device is also arranged.

9. The method according to claim 8, wherein the positioning device is a rail device that can be moved in a horizontal direction, and the first dosing device is fixed on the positioning device so as to be movable in the vertical direction.

10. The method according to claim 1, further comprising subsequent to the pressing of the first active substance and prior to the releasing of the pressed tablet: inputting a second-layer target mass and transmitting the second-layer target mass to the controller, wherein the second-layer target mass indicates a quantity of a second active substance per tablet, positioning a second dosing device of a second material container above the central opening by a positioning device, filling a second quantity of the second active substance that corresponds to a second-layer target mass into the central opening by the second dosing device, positioning the upper punch above the central opening by the positioning device, and pressing the second active substance by extending the pressure face of the upper punch into the central opening, wherein, the repeating comprises repeating the filling of the quantity of the first active substance, pressing of the first active substance, filling the second quantity of the second active substance pressing the second active substance and releasing of the pressed tablet until the number of pressed tablets corresponds to the target number.

11. A tablet press for automatically producing a specifiable number of individualized tablets with a specifiable quantity of a first active substance, the tablet press comprising: a press chamber, a first material container configured to be filled with the first active substance, a first dosing device, a controller, and an input device, wherein the press chamber has an extendable upper punch, an extendable lower punch, at least one die, and a weighing device arranged under the at least one die, by which a mass of a material filled into a central opening in the die is measurable by placing the die and the lower punch on the weighing device, the input device is configured to transmit a target number and a target mass of the individualized tablets to be produced to the controller, and the controller is configured to read out measured data from the weighing device and actuate the first dosing device, the upper punch, and the lower punch such that a quantity of the first active substance that corresponds to the target mass is filled into the central opening of the die and pressed by the upper punch and the lower punch into a tablet, and to repeat the pressing until a target number of tablets has been produced.

12. The tablet press according to claim 8, wherein the upper punch comprises at least two vertically telescoping upper punch shafts arranged inside each other, by which an outer circumference of a pressure face of the upper punch can be adapted to the inner circumference of the central opening of the at least one die by individually extending the upper punch shafts.

13. The tablet press according to claim 12, wherein the lower punch comprises at least two vertically telescoping lower punch shafts arranged inside each other, by which an outer circumference of a pressure face of the lower punch can be adapted to the inner circumference of the central opening of the at least one die by individually extending the lower punch shafts.

14. The tablet press according to claim 13, wherein the press chamber comprises a first pushing and pulling device, by which at least one upper locking pin can be pushed into a horizontal hole in side walls of the upper punch shafts to vertically fix a definable number of the upper punch shafts, wherein the press chamber comprises a second pushing and pulling device, by which at least one lower locking pin is pushed into a horizontal hole in side walls of the lower punch shafts to vertically fix a definable number of the lower punch shafts.

15. The tablet press according to claim 11, wherein the tablet press further comprises at least one lifting device that is configured to lift and lower the at least one die and the lower punch.

16. The tablet press according to claim 15, wherein the at least one lifting device is configured to lift and lower the at least one die and the lower punch in a vertical direction (120).

17. The tablet press according to claim 11, further comprising a positioning device by which the upper punch and the first dosing device can alternatingly be arranged vertically above the central opening in the die arranged above the lower punch.

18. The tablet press according to claim 17, wherein the positioning device further arranges a second dosing device of a second material container above the central opening in the die.

19. The tablet press according to claim 17, wherein the positioning device is a rail device on which the first dosing device and the upper punch are arranged and can be moved in a horizontal direction, wherein the first dosing device is movably arranged on the rail device in a vertical direction.

20. The tablet press according to claim 11, wherein the lower punch has a recess in its lower side that is configured to form-fit with an elevation on an upper side of the weighing device.

Description

[0084] The embodiments are described below, without restricting the general idea of the invention, based on exemplary embodiments in reference to the drawings, whereby we expressly refer to the drawings with regard to the disclosure of all details that are not explained in greater detail in the text. In the drawings:

[0085] FIG. 1 illustrates a schematically simplified diagram of a tablet press for automatically producing a specifiable number of individualized tablets with a specifiable quantity of a first active substance,

[0086] FIG. 2 illustrates a schematically simplified diagram of an input device of the tablet press from FIG. 1,

[0087] FIG. 3 illustrates a schematically simplified cross-sectional view of a press chamber and a material container of a tablet press while adding an active substance,

[0088] FIG. 4a illustrates a schematically simplified cross-sectional view of a press chamber and a material container of a tablet press during pressing of an active substance,

[0089] FIG. 4b illustrates a schematically simplified cross-sectional view of a lower punch and a die which are coupled by a spring, and a weighing device,

[0090] FIG. 4c illustrates a schematically simplified cross-sectional view of the lower punch of the die, and the weighing device of FIG. 4b while filling,

[0091] FIG. 5 illustrates a schematically simplified plan view of a first positioning device,

[0092] FIG. 6 illustrates a schematically simplified plan view of a second positioning device,

[0093] FIG. 7a-d illustrate schematically simplified diagrams of an upper punch with telescoping upper punch shafts arranged inside each other and a lower punch with telescoping lower punch shafts arranged inside each other,

[0094] FIG. 8a-c illustrate schematically simplified cross-sectional views of an upper punch, a lower punch, and multiple dies during the pressing process of tablets with different active substance quantities,

[0095] FIG. 9a-c illustrate schematically simplified plan views of an upper punch during the pressing process of tablets with different active substance quantities.

[0096] In the drawings, the same or similar elements and/or parts are, in each case, provided with the same reference numerals such that they are not introduced again in each case.

DETAILED DESCRIPTION

[0097] FIG. 1 shows a schematically simplified exemplary embodiment of a tablet press 1. The tablet press 1 comprises a press chamber 2, a first material container 10 that is filled with a first active substance 14, a receiving chamber 3 in which a tablet container 100 can be arranged, a transfer device 4 for transporting the produced tablets from the press chamber 2 into the tablet container 100, a control system 6 for controlling the tablet press 1, and an input device 30 for operating the tablet press 1. In the embodiment of the tablet press 1 shown in FIG. 1, the first material container 10 is arranged in a housing of the tablet press 1 and is detachably fixed there. For example, the first material container 10 can be removed from the housing through a flap, which is not shown, in order to replace or refill it. The input device 30 can comprise a security access system. For example, the input device 30 is secured by an access code or comprises a fingerprint scanner.

[0098] According to one embodiment, the press chamber 2 is configured as an exchangeable press chamber insert. For this purpose, the press chamber 2 is removably fixed in the tablet press 1. To be exchanged, the press chamber insert can be removed from the tablet press and replaced by another press chamber insert.

[0099] The control system 6 is, for example, a computer, controller, processor, circuit(s), CPU, etc. that is configured to control the tablet press 1 such that a target number of individualized tablets with a target mass of the first active substance 14 is produced automatically. The receiving chamber 3 can be closed according to an embodiment such that no dust escapes from the tablet press 1 and no contaminants enter the tablet press 1 during the production of the tablets.

[0100] FIG. 2 shows a schematically simplified detailed view of the input device 30 which is a touchscreen on the tablet press 1 in the shown embodiment. The input device 30 comprises a data display 31, for example a region of the screen, on which information about the first active substance 14 and/or a patient is displayed. The input device 30 further comprises multiple input means 32, 33, 34, which are, for example, additional regions of the screen. By the input means 32, 33, 34, the target number 35, the target mass 36, and if necessary, a second-layer target mass 37 can be input. The input values are displayed for verification. In addition, a further input means (not shown) is provided, with which the production of the tablets can be started. According to another embodiment, the input device 30 is an external unit or an interface for communicating with an external unit. In this case, the target number 35, the target mass 36 and, if applicable, the second layer target mass 37 are entered in the external unit and transmitted to the control system 6.

[0101] In FIG. 3, a schematically simplified cross-sectional view of an embodiment of the tablet press 1 with the press chamber 2 and the first material container 10 is shown. The first material container 10 comprises a first dosing device 12 for filling the first active substance 14 into the central opening of a die 60. According to another embodiment, the first material container 10 is connected to the first dosing device 12. The first dosing device 12 is, for example, a closable funnel.

[0102] A lower punch 50 is arranged in the press chamber 2 such that it extends from below into the die 60. The lower punch 50 can be extended in a vertical direction. Before the first active substance 14 is filled into the die 60, the lower punch 50 is extended into the die 60 from below such that a trough for receiving the first active substance 14 is created. Alternatively, the lower punch 50 is permanently arranged in the die 60. In both cases, the lower punch 50 can be moved in a vertical direction 120 in the central opening in the die.

[0103] The die 60 and/or the lower punch 50 are arranged on a platform 70. According to one embodiment, the platform 70 is a first positioning device. Additional dies (not shown in FIG. 3) are fixed to this first positioning device and can be moved into a position above the lower punch 50 by rotating the first positioning device. According to an alternative embodiment, only one die 60 and one lower punch 50 are affixed to the platform 70.

[0104] The platform 70 and therefore the die 60 and the lower punch 50 as well can be raised and lowered in a vertical direction 120 by a lifting device 130 that comprises a first spindle 131 and a second spindle 132. Moreover, the pressure acting on the lower punch 50 during the pressing process can be determined by a pressure measuring device (not shown) on the lifting device 130 and/or by the power consumption of the lifting device 130. A weighing device 16 is arranged below the die 60 and the lower punch 50.

[0105] An upper punch 40 surrounded and supported by an upper punch carrier 41 is also arranged in the tablet press 1. The upper punch 40 can be extended in the vertical direction by an upper piston 96.

[0106] The first dosing device 12 and the upper punch 40 are fixed to a second positioning device 80, which is a rail device in the shown embodiment.

[0107] To fill the die 60 with the first active substance 14, the second positioning device 80 is actuated by the control system 6 such that the first dosing device 12 is arranged above the lower punch 50 and the die 60, as shown in FIG. 3. Naturally, this only occurs if the first dosing device 12 is not yet arranged above the lower punch 50. Moreover, the die 60 and the lower punch 50 are placed on the weighing device 16 so that, by the weighing device 16, the overall weight of the die 60, the lower punch 50, as well as the first active substance 14 filled into the die are measured. To prevent the first active substance 14 from spilling while being added, the first dosing device 12 is lowered so that the bottom end of the first dosing device 12 is below the upper edge of the die 60. Then, the central opening of the die 60 is filled with the first active substance 14 by the first dosing device 12 until the target mass 36 is reached. This is monitored with the weighing device 16.

[0108] After the die 60 is filled, the first active substance 14 is pressed. This is shown in FIG. 4a. For this purpose, the die 60 and the lower punch 60 are lifted off the weighing device 16 by the lifting device 130, the dosing device 12 is moved vertically upward, and the second positioning device 80 is controlled by the control system 6 so that the upper punch 40 is arranged above the lower punch 50 and the die 60. Then, the upper punch 40 is extended into the central opening of the die 60 from above by the upper piston 96. In this manner, the first active substance 14 is pressed between the pressure faces of the lower punch 50 and the upper punch 40 in order to form a tablet.

[0109] After pressing the tablet, both the upper punch 40 and the lower punch 50 move upwards to release the tablet from the die 60. Then, the tablet is pushed down from the lower punch 50, for example by a pushing device (not shown) of the transfer device 4, such that it falls through a channel of the transfer device 4 into the tablet container 100.

[0110] This method is repeated until the target number 35 of tablets has been produced. After that, the receiving chamber 3 can be opened and the tablet container 100 removed. The tablet container 100 is now filled with the target number 35 of individualized tablets with the target mass 36 of the first active substance 14.

[0111] FIG. 4b shows a schematically simplified cross-sectional view of an exemplary embodiment of a weighing device 16, a die 60, and a lower punch 50. In the shown embodiment, only one die 60 is included that forms a unit together with the lower punch 50, and they are coupled to each other by a spring 65. In FIG. 4b, the spring 65 is compressed, whereby the lower punch 50 extends to the upper edge of the central opening 60a of the die. This is for example recommendable while ejecting a pressed tablet. The unit consisting of the lower punch 50 and the die 60 is arranged on the platform 70 that can be moved in a vertical direction 120 by the lifting device 130. The weighing device 16 is arranged below the die 60 and the lower punch 50. On its upper side, the weighing device 15 has an elevation 17 that is configured to form-fit with a recess 51 in the lower side of the lower punch 50. The recess 51 of the lower punch 51 is adjacent to a recess 71 in the platform 70 that together form a cavity which is shown with a dashed line in FIG. 4b. With the recess 71, the weighing device 16 can move through the platform 70 so that it comes into contact with the lower punch. The lifting device 130 also comprises a pressure measuring device 94. This pressure measuring 94 device is for example a piezoelectric load cell, a pneumatic load cell or a hydraulic load cell. With the pressure measuring 94, the pressure acting on the punches can be measured during the pressing process.

[0112] FIG. 4c shows the system from FIG. 4b while adding an active substance. The die 60 and the lower punch 50 are pulled apart in a vertical direction 120 under the spring force of the spring 65 which produces a trough in the central opening 60a of the die 60 into which the active substance is filled. The lower punch 50 lies on the weighing device 16 so that the elevation 17 engages in a form-fit in the seat 51. The platform 70 is lowered until the lower punch 50 lies exclusively on the weighing device 16 and not on the platform 70. In this way, the weighing device 16 measures the total mass of the lower punch 50, the die 60, and the active substance filled into the trough while filling. The active substance is added as usual by the dosing device 12 which is not shown in FIGS. 4b and 4c.

[0113] FIG. 5 shows a schematically simplified top view of a platform 70 configured as a first positioning device according to a possible embodiment of the tablet press 1. In the shown embodiment, the first positioning device is configured as a rail device. Three dies 60, 61, 62 are fixed to the first positioning device. The dies 60, 61, 62 each have a central opening 60a, 61a, 62a with different circular inner circumferences 60b, 61b, 62b. The central openings 60a, 61a, 62a pass through the platform 70 such that the punches 40, 50 are not blocked by the platform 70. Which of the dies 60, 61, 62 is arranged above the lower punch 50 can be set by translating the first positioning device in a horizontal direction 110. In this manner, a target circumference of the produced tablets can be set such that tablets with a wide range of target masses 36 of the first active substance 14 can be produced of the tablet press 1.

[0114] Alternatively, oval or other shapes can be provided instead of the circular shape of the central openings 60a, 61a, 62a, enabling the shape of the tablets to be adjusted.

[0115] FIG. 6 shows a schematically simplified plan view of the second positioning device 80. In the shown embodiment, this is configured as a rail device. The upper punch 40, the first material container 10 and, in the shown embodiment, a second material container 20 are fixed to the rail device and can be alternately arranged above the lower punch 50 by being translated in a horizontal direction 110 by the rail device.

[0116] The second material container 20 is filled with a second active substance 24 for producing a two-layer tablet. For this purpose, e.g., after the pressing of the first active substance 14 by the second positioning device 80, the second dosing device 22 of the second material container 20 is arranged above the lower punch 50 and the central opening 60a of the die 60 arranged thereon is filled with the second active substance 24. Then, the upper punch 40 is moved above the lower punch 50 and the two-layer tablet is pressed. To produce a two-layer tablet with adjacent layers, a first corner of the die 60 is filled with the first active substance 14 by the first dosing device 12, and a second corner of the die 60 is filled with the second active substance 24 by the second dosing device, and the tablet is then pressed. As the dosing devices 12, 22 are arranged below the material containers 10, 20, the dosing devices 12, 22 would normally not be visible in FIG. 6 and are thus drawn with dashed lines.

[0117] FIGS. 7a and 7b show an embodiment of a telescoping upper punch 40. The upper punch 40 comprises three telescoping upper punch shafts 44, 45, 46 arranged inside each other. In FIG. 7a, all three upper punch shafts 44, 45, 46 are extended together such that the outer circumference 43 of the pressure face 42 of the upper punch 40 corresponds to the outer circumference of the outermost upper punch shaft 46. In FIG. 7b, exclusively the innermost upper punch shaft 44 is extended such that the outer circumference 43 of the pressure face 42 of the upper punch 40 corresponds to the outer circumference of the innermost upper punch shaft 44. The outer circumferences of the upper punch shafts 44, 45, 46 are each complementary in shape to the inner circumferences 60b, 61b, 62b of the dies 60, 61, 62.

[0118] FIGS. 7c and 7d show an embodiment of a telescoping lower punch 50 that is formed as a mirror image to the upper punch 40. Just as with the upper punch 40, the outer circumference 53 of the pressure face 52 of the lower punch 50 can be varied by individually extending the lower punch shafts 54, 55, 56.

[0119] In FIG. 8a, a schematically simplified cross-sectional view of a telescoping upper punch 40, a telescoping lower punch 50, and a die 60 are shown during the pressing of a large tablet 101. In this case, the die 60 with the large central opening 60a is used. To press the tablet 101, all upper punch shafts 44, 45, 46 and lower punch shafts 54, 55, 56 are used. In the shown embodiment, one or more horizontal holes 47 are provided in the upper punch shafts 44, 45, 46, into which holes upper locking pins 48 can be pushed by one or more schematically indicated first pushing and pulling devices 49. Analogously, in the shown embodiment, one or more horizontal holes 57 are provided in the lower punch shafts 54, 55, 56, into which holes lower locking pins 58 can be pushed by one or more schematically indicated second pushing and pulling devices 59. Since the largest die 60 is used, the locking pins 48, 58 are retracted such that they do not engage in the horizontal holes 47, 57. The pushing direction of the upper piston 96 is represented by an arrow.

[0120] FIG. 8b shows a schematically simplified cross-sectional view during the production of a tablet 102 with a medium size. For this purpose, the die 61 is used that has the central opening 61a with the medium size. The locking pins 48, 58 are partially inserted into the holes 47, 57 such that the outermost punch shafts 46, 56 are vertically fixed and only the middle and the inner punch shafts 44, 45, 54, 55 are extended. In this manner, the outer circumferences 43, 53, of the pressure faces 42, 52 are adapted to the inner circumference 61b of the die 61.

[0121] FIG. 8c shows a schematically simplified cross-sectional view during the production of a small tablet 103. For this purpose, the die 62 is used that has the smallest central opening 62a. The locking pins 48, 58 are fully inserted into the holes 47, 57 such that the outermost and the middle punch shafts 45, 46, 55, 56 are vertically fixed and only the inner punch shafts 44, 45, 54, 55 are extended. In this manner, the outer circumferences 43, 53, of the pressure faces 42, 52 are adapted to the inner circumference 62b of the die 62.

[0122] FIG. 9a shows a schematically simplified plan view of FIG. 8a with an additional representation of the upper punch carrier 41 as the outermost ring. A further horizontal hole 91 is provided perpendicularly to the holes 47. A coupling pin 92 is guided in the hole 91 and is inserted into and retracted from the hole 91 by a third pushing and pulling device 90.

[0123] In the shown embodiment in FIG. 8a, 8b, 8c, 9a, 9b, 9c, the upper piston 96 directly drives exclusively the inner upper punch shaft 44, while a lower piston (not shown) directly drives exclusively the inner lower punch shaft 54. By the coupling pin 92, the upper punch shafts 44, 45, 46 are coupled with each other, if necessary, such that they are moved up and down synchronously. This is provided analogously for the lower punch 50. In FIG. 9a, the coupling pin 92 couples all three upper punch shafts 44, 45, 46 with each other such that they are vertically extended together. A vertical groove is provided in the upper punch carrier 41 so that the third pushing and pulling device 90 does not block in the upper punch carrier 41.

[0124] FIG. 9b shows a schematically simplified plan view of FIG. 8b. The coupling pin 92 couples only the inner upper punch shaft 44 with the middle upper punch shaft 45, while the outer upper punch shaft 46 is vertically fixed.

[0125] FIG. 9c shows a schematically simplified plan view of FIG. 8c. The coupling pin 92 is inserted such that only the inner upper punch shaft 44 is extended, while the middle upper punch shaft 45 and the outer upper punch shaft 46 are vertically fixed.

[0126] While there has been shown and described what is considered to be preferred embodiments, it will, of course, be understood that various modifications and changes in form or detail could readily be made without departing from the spirit of the invention. It is therefore intended that the invention be not limited to the exact forms described and illustrated, but should be constructed to cover all modifications that may fall within the scope of the appended claims.

LIST OF REFERENCE SIGNS

[0127] 1 Tablet press [0128] 2 Press chamber [0129] 3 Receiving chamber [0130] 4 Transfer device [0131] 6 Control system [0132] 10 First material container [0133] 12 First dosing device [0134] 14 First active substance [0135] 16 Weighing device [0136] 17 Elevation [0137] 20 Second material container [0138] 22 Second dosing device [0139] 24 Second active substance [0140] 30 Input device [0141] 31 Data display [0142] 32, 33, 34 Input means [0143] 35 Target number [0144] 36 Target mass [0145] 37 Second-layer target mass [0146] 40 Upper punch [0147] 41 Upper punch carrier [0148] 42 Pressure face [0149] 43 Outer circumference [0150] 44, 45, 46 Upper punch shafts [0151] 47 Horizontal hole [0152] 48 Upper locking pin [0153] 49 First pushing and pulling device [0154] 50 Lower punch [0155] 51 Recess [0156] 52 Pressure face [0157] 53 Outer circumference [0158] 54, 55, 56 Lower punch shafts [0159] 57 Horizontal hole [0160] 58 Lower locking pin [0161] 59 Second pushing and pulling device [0162] 60, 61, 62 Die [0163] 60a, 61a, 62a Central opening [0164] 60b, 61b, 62b Inner circumference [0165] 65 Spring [0166] 70 Platform [0167] 71 Recess [0168] 80 Second positioning device [0169] 90 Third pushing and pulling device [0170] 91 Horizontal hole [0171] 92 Coupling pin [0172] 94 Pressure measuring device [0173] 96 Upper piston [0174] 100 Tablet container [0175] 101, 102, 103 Tablet [0176] 110 Horizontal direction [0177] 120 Vertical direction [0178] 130 Lifting device [0179] 131 First spindle [0180] 132 Second spindle