Production of steviol glycosides in recombinant hosts
10837041 · 2020-11-17
Assignee
Inventors
- Veronique Douchin (Frederiksberg, DK)
- Michael Dalgaard Mikkelsen (Vaerlose, DK)
- Iben Møller-Hansen (Frederiksberg, DK)
Cpc classification
C12P19/56
CHEMISTRY; METALLURGY
C12N9/0073
CHEMISTRY; METALLURGY
C12N15/8243
CHEMISTRY; METALLURGY
C12N15/8257
CHEMISTRY; METALLURGY
C07H3/06
CHEMISTRY; METALLURGY
C12N15/746
CHEMISTRY; METALLURGY
International classification
C12P21/06
CHEMISTRY; METALLURGY
C07H3/06
CHEMISTRY; METALLURGY
C12N15/82
CHEMISTRY; METALLURGY
C12P19/56
CHEMISTRY; METALLURGY
C12N15/74
CHEMISTRY; METALLURGY
Abstract
The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
Claims
1. A recombinant host cell producing a steviol glycoside in a cell culture, wherein the host cell comprises a recombinant gene encoding a Sugar Efflux Transporter (SET) polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:18; wherein the recombinant host cell expresses exogenous nucleic acids encoding: (a) a polypeptide capable of synthesizing geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP); (b) a polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP; (c) a polypeptide capable of synthesizing ent-kaurenoic acid from ent-kaurene; (d) a polypeptide capable of synthesizing ent-kaurene from ent-copalyl pyrophosphate; (e) a polypeptide capable of synthesizing steviol from ent-kaurenoic acid; (f) a polypeptide capable of reducing cytochrome P450 complex; and (g) one or more uridine diphosphate (UDP) glycosyltransferases (UGTs) polypeptide; and wherein the host cell is a plant cell, a fungal cell, or a bacterial cell.
2. The host cell of claim 1, wherein the host cell further comprises a deletion of a gene encoding a trafficking adapter polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:46.
3. The host cell of claim 2, wherein the deletion of the gene encoding the polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:46 increases excretion of Rebaudioside D (RebD).
4. The host cell of claim 2, wherein the deletion of the gene encoding the polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:48 increases excretion of Rebaudioside M (RebM).
5. The host cell of claim 1, wherein the host cell further comprises a deletion of a gene encoding a transporter polypeptide having the amino acid sequence set forth in SEQ ID NO:102 or a functional homolog thereof.
6. The recombinant host cell of claim 1, wherein: (a) the polypeptide capable of synthesizing geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP) comprises a polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:182; (b) the polypeptide capable of synthesizing ent-copalyl diphosphate from GGPP comprises a polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:184; (c) the polypeptide capable of synthesizing ent-kaurenoic acid from ent-kaurene comprises a polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:188; (d) the polypeptide capable of synthesizing ent-kaurene from ent-copalyl pyrophosphate comprises a polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:186; (e) the polypeptide capable of synthesizing steviol from ent-kaurenoic acid comprises a polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:192; (f) the polypeptide capable of reducing cytochrome P450 complex comprises a polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:194; and wherein the one or more uridine diphosphate (UDP) glycosyltransferases (UGTs) polypeptide comprises: (g) a polypeptide capable of glycosylating steviol or a steviol glycoside at its C-13 hydroxyl group; wherein the polypeptide comprises a polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:196; (h) a polypeptide capable of beta 1,3 glycosylation of the C3 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; wherein the polypeptide comprises a polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO: 200; (i) a polypeptide capable of glycosylating steviol or a steviol glycoside at its C-19 carboxyl group; wherein the polypeptide comprises a polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:198; and/or (j) a polypeptide capable of beta 1,2 glycosylation of the C2 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; wherein the polypeptide comprises a polypeptide having at least 95% sequence identity to the amino acid sequence set forth in SEQ ID NO:204.
7. The host cell of claim 1, wherein the bacterial cell comprises Escherichia bacteria cells, Lactobacillus bacteria cells, Lactococcus bacteria cells, Cornebacterium bacteria cells, Acetobacter bacteria cells, Acinetobacter bacteria cells, or Pseudomonas bacterial cells.
8. The host cell of claim 1, wherein the fungal cell is a yeast cell.
9. The host cell of claim 8, wherein the yeast cell is a cell from Saccharomyces cerevisiae, Schizosaccharomyces pombe, Yarrowia lipolytica, Candida glabrata, Ashbya gossypii, Cyberlindnera jadinii, Pichia pastoris, Kluyveromyces lactis, Hansenula polymorpha, Candida boidinii, Arxula adeninivorans, Xanthophyllomyces dendrorhous, or Candida albicans species.
10. The host cell of claim 5, wherein the host cell excretes a decreased amount of steviol-13-O-glucoside (13-SMG) relative to a steviol glycoside-producing host cell that does not have the deletion of the one or more genes encoding the one or more transporter polypeptides.
11. The host cell of claim 5, wherein the host cell excretes an increased amount of RebA, RebB, RebD, and/or RebM relative to a steviol glycoside-producing host cell that does not have the deletion of the one or more genes encoding the one or more transporter polypeptides.
12. The host cell of claim 5, wherein the host cell produces an increased amount of RebA, RebB, RebD, and/or RebM relative to a steviol glycoside-producing host cell that does not have the deletion of the one or more genes encoding the one or more transporter polypeptides.
13. A method of increasing production of a steviol glycoside in a recombinant host cell or increasing excretion of a steviol glycoside into a culture medium, comprising culturing the host cell of claim 1 in a cell culture, under conditions in which one or more of the genes are expressed; wherein the steviol glycoside is produced by the host cell.
14. The method of claim 13, wherein the steviol glycoside is RebA, RebB, RebD, and/or RebM.
15. A method of increasing an amount of RebA, RebB, RebD, and/or RebM produced by a recombinant host cell, comprising culturing the host cell of claim 1 in a cell culture; wherein excretion of 13-SMG from the host cell into the cell culture is decreased relative to RebA, RebB, RebD, and/or RebM-producing host cell that does not have the deletion of the one or more genes encoding the one or more transporter polypeptides; wherein RebA, RebB, RebD, and/or RebM are produced by the host cell.
16. The method of claim 13, that further comprises isolating RebA, RebB, RebD, and/or RebM, alone or in combination from the cell culture.
17. The method of claim 16, wherein the isolating step comprises separating a liquid phase of the cell culture from a solid phase of the cell culture to obtain a supernatant comprising RebA, RebB, RebD, and/or RebM, alone or in combination, and: (a) contacting the supernatant with one or more adsorbent resins in order to obtain at least a portion of RebA, RebB, RebD, and/or RebM, alone or in combination; or (b) contacting the supernatant with one or more ion exchange or reversed-phase chromatography columns in order to obtain at least a portion of RebA, RebB, RebD, and/or RebM, alone or in combination; or (c) crystallizing or extracting RebA, RebB, RebD, and/or RebM, alone or in combination; thereby isolating RebA, RebB, RebD, and/or RebM, alone or in combination.
18. The method of claim 13, that further comprises recovering RebA, RebB, RebD, and/or RebM alone or a composition comprising RebA, RebB, RebD, and/or RebM from the cell culture.
19. The method of claim 18, wherein the recovered composition is enriched for RebA, RebB, RebD, and/or RebM, relative to a steviol glycoside composition of Stevia plant and has a reduced level of Stevia plant-derived components relative to a steviol glycoside composition obtained from a plant-derived Stevia extract.
20. The method of claim 13, wherein the cell culture comprises: (a) RebA, RebB, RebD, and/or RebM produced by the host cell of claim 1, (b) glucose, fructose, sucrose, xylose, rhamnose, uridine diphosphate (UDP)-glucose, UDP-rhamnose, UDP-xylose, and/or N-acetyl-glucosamine; and (c) supplemental nutrients comprising trace metals, vitamins, salts, yeast nitrogen base (YNB), and/or amino acids.
21. A cell culture, comprising the host cell of claim 1, the cell culture further comprising: (a) RebA, RebB, RebD, and/or RebM produced by the host cell; (b) glucose, fructose, sucrose, xylose, rhamnose, uridine diphosphate (UDP)-glucose, UDP-rhamnose, UDP-xylose, and/or N-acetyl-glucosamine; and (c) supplemental nutrients comprising trace metals, vitamins, salts, YNB, and/or amino acids; wherein RebA, RebB, RebD, and/or RebM are present at a concentration of at least 1 mg/liter of the cell culture.
22. A cell lysate, comprising RebA, RebB, RebD, and/or RebM produced by the host cell of claim 1, and the cell lysate further comprising glucose, fructose, sucrose, xylose, rhamnose, uridine diphosphate (UDP)-glucose, UDP-rhamnose, UDP-xylose, and/or N-acetyl-glucosamine, supplemental nutrients comprising trace metals, vitamins, salts, YNB, and/or amino acids.
23. The host cell of claim 1, wherein the host cell is a Yarrowia lipolytica cell.
24. The method of claim 13, wherein: (a) Reb A is produced in the recombinant host cell expressing the polypeptide capable of glycosylating steviol or a steviol glycoside at its C-13 hydroxyl group; the polypeptide capable of beta 1,3 glycosylation of the C3 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-0-glucose of a steviol glycoside; the polypeptide capable of glycosylating steviol or a steviol glycoside at its C-19 carboxyl group; and the polypeptide capable of beta 1,2 glycosylation of the C2 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; (b) Reb B is produced in the recombinant host cell expressing the polypeptide capable of glycosylating steviol or a steviol glycoside at its C-13 hydroxyl group; the polypeptide capable of beta 1,3 glycosylation of the C3 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-0-glucose of a steviol glycoside; and the polypeptide capable of beta 1,2 glycosylation of the C2 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; (c) Reb D is produced in the recombinant host cell expressing the polypeptide capable of glycosylating steviol or the steviol glycoside at its C-13 hydroxyl group; the polypeptide capable of beta 1,3 glycosylation of the C3 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-0-glucose of a steviol glycoside; the polypeptide capable of glycosylating steviol or a steviol glycoside at its C-19 carboxyl group; and the polypeptide capable of beta 1,2 glycosylation of the C2 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; and/or (d) Reb M is produced in the recombinant host cell expressing the polypeptide capable of glycosylation of the 13-OH of steviol; the polypeptide capable of beta 1,3 glycosylation of the C3 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; the polypeptide capable of glycosylating steviol or a steviol glycoside at its C-19 carboxyl group; and the polypeptide capable of beta 1,2 glycosylation of the C2 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside.
25. The method of claim 13, wherein Reb A is produced in the recombinant host cell expressing the polypeptide capable of glycosylating steviol or a steviol glycoside at its C-13 hydroxyl group; the polypeptide capable of beta 1,3 glycosylation of the C3 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; the polypeptide capable of glycosylating steviol or a steviol glycoside at its C-19 carboxyl group; and the polypeptide capable of beta 1,2 glycosylation of the C2 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside.
26. The method of claim 13, wherein Reb D is produced in the recombinant host cell expressing the polypeptide capable of glycosylating steviol or the steviol glycoside at its C-13 hydroxyl group; the polypeptide capable of beta 1,3 glycosylation of the C3 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; the polypeptide capable of glycosylating steviol or a steviol glycoside at its C-19 carboxyl group; and the polypeptide capable of beta 1,2 glycosylation of the C2 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside.
27. The method of claim 13, wherein Reb M is produced in the recombinant host cell expressing the polypeptide capable of glycosylation of the 13-OH of steviol; the polypeptide capable of beta 1,3 glycosylation of the C3 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside; the polypeptide capable of glycosylating steviol or a steviol glycoside at its C-19 carboxyl group; and the polypeptide capable of beta 1,2 glycosylation of the C2 of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of a steviol glycoside.
28. The recombinant host of claim 1, wherein the steviol glycoside is Rebaudioside A (Reb A), Rebaudioside B (Reb B), Reb D and/or Reb M or an isomer thereof.
Description
DESCRIPTION OF DRAWINGS
(1) The following detailed description of the embodiments of the present invention can be best understood when read in conjunction with the following drawings, where like structure is indicated with like reference numerals and in which:
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(5) Skilled artisans will appreciate that elements in the Figures are illustrated for simplicity and clarity and have not necessarily been drawn to scale. For example, the dimensions of some of the elements in the Figures can be exaggerated relative to other elements to help improve understanding of the embodiment(s) of the present invention.
DETAILED DESCRIPTION
(6) All publications, patents and patent applications cited herein are hereby expressly incorporated by reference in their entirety for all purposes.
(7) Before describing the present invention in detail, a number of terms will be defined. As used herein, the singular forms a, an, and the include plural referents unless the context clearly dictates otherwise. For example, reference to a nucleic acid means one or more nucleic acids.
(8) It is noted that terms like preferably, commonly, and typically are not utilized herein to limit the scope of the claimed invention or to imply that certain features are critical, essential, or even important to the structure or function of the claimed invention. Rather, these terms are merely intended to highlight alternative or additional features that can or cannot be utilized in a particular embodiment of the present invention.
(9) For the purposes of describing and defining the present invention it is noted that the term substantially is utilized herein to represent the inherent degree of uncertainty that can be attributed to any quantitative comparison, value, measurement, or other representation. The term substantially is also utilized herein to represent the degree by which a quantitative representation can vary from a stated reference without resulting in a change in the basic function of the subject matter at issue.
(10) Methods well known to those skilled in the art can be used to construct genetic expression constructs and recombinant cells according to this invention. These methods include in vitro recombinant DNA techniques, synthetic techniques, in vivo recombination techniques, and polymerase chain reaction (PCR) techniques. See, for example, techniques as described in Green & Sambrook, 2012, MOLECULAR CLONING: A LABORATORY MANUAL, Fourth Edition, Cold Spring Harbor Laboratory, New York; Ausubel et al., 1989, CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, Greene Publishing Associates and Wiley Interscience, New York, and PCR Protocols: A Guide to Methods and Applications (Innis et al., 1990, Academic Press, San Diego, Calif.).
(11) As used herein, the terms polynucleotide, nucleotide, oligonucleotide, and nucleic acid can be used interchangeably to refer to nucleic acid comprising DNA, RNA, derivatives thereof, or combinations thereof.
(12) As used herein, the terms microorganism, microorganism host, microorganism host cell, host cell, recombinant host, recombinant microorganism host, and recombinant host cell can be used interchangeably. As used herein, the term recombinant host is intended to refer to a host, the genome of which has been augmented by at least one DNA sequence. Such DNA sequences include but are not limited to genes that are not naturally present, DNA sequences that are not normally transcribed into RNA or translated into a protein (expressed), and other genes or DNA sequences which one desires to introduce into the non-recombinant host. It will be appreciated that typically the genome of a recombinant host described herein is augmented through stable introduction of one or more recombinant genes. Generally, introduced DNA is not originally resident in the host that is the recipient of the DNA, but it is within the scope of this disclosure to isolate a DNA segment from a given host, and to subsequently introduce one or more additional copies of that DNA into the same host, e.g., to enhance production of the product of a gene or alter the expression pattern of a gene. In some instances, the introduced DNA will modify or even replace an endogenous gene or DNA sequence by, e.g., homologous recombination or site-directed mutagenesis. Suitable recombinant hosts include microorganisms.
(13) As used herein, the term recombinant gene refers to a gene or DNA sequence that is introduced into a recipient host, regardless of whether the same or a similar gene or DNA sequence may already be present in such a host. Introduced, or augmented in this context, is known in the art to mean introduced or augmented by the hand of man. Thus, a recombinant gene can be a DNA sequence from another species or can be a DNA sequence that originated from or is present in the same species but has been incorporated into a host by recombinant methods to form a recombinant host. It will be appreciated that a recombinant gene that is introduced into a host can be identical to a DNA sequence that is normally present in the host being transformed, and is introduced to provide one or more additional copies of the DNA to thereby permit overexpression or modified expression of the gene product of that DNA. Said recombinant genes are particularly encoded by cDNA.
(14) As used herein, the term engineered biosynthetic pathway refers to a biosynthetic pathway that occurs in a recombinant host, as described herein. In some aspects, one or more steps of the biosynthetic pathway do not naturally occur in an unmodified host. In some embodiments, a heterologous version of a gene is introduced into a host that comprises an endogenous version of the gene.
(15) As used herein, the term endogenous gene refers to a gene that originates from and is produced or synthesized within a particular organism, tissue, or cell. In some embodiments, the endogenous gene is a yeast transporter. In some embodiments, the transporter is endogenous to S. cerevisiae, including, but not limited to S. cerevisiae strain S288C. In some embodiments, an endogenous yeast transporter gene is overexpressed. As used herein, the term overexpress is used to refer to the expression of a gene in an organism at levels higher than the level of gene expression in a wild type organism. See, e.g., Prelich, 2012, Genetics 190:841-54. In some embodiments, an endogenous yeast transporter gene is deleted. See, e.g., Giaever & Nislow, 2014, Genetics 197(2):451-65. As used herein, the terms deletion, deleted, knockout, and knocked out can be used interchangeably to refer to an endogenous gene that has been manipulated to no longer be expressed in an organism, including, but not limited to, S. cerevisiae. In some embodiments, a deleted/knocked out gene is a transporter gene or a transcription factor gene that regulates expression of a transporter gene.
(16) As used herein, the terms heterologous sequence and heterologous coding sequence are used to describe a sequence derived from a species other than the recombinant host. In some embodiments, the recombinant host is an S. cerevisiae cell, and a heterologous sequence is derived from an organism other than S. cerevisiae. A heterologous coding sequence, for example, can be from a prokaryotic microorganism, a eukaryotic microorganism, a plant, an animal, an insect, or a fungus different than the recombinant host expressing the heterologous sequence. In some embodiments, a coding sequence is a sequence that is native to the host.
(17) A selectable marker can be one of any number of genes that complement host cell auxotrophy, provide antibiotic resistance, or result in a color change. Linearized DNA fragments of the gene replacement vector then are introduced into the cells using methods well known in the art (see below). Integration of the linear fragments into the genome and the disruption of the gene can be determined based on the selection marker and can be verified by, for example, PCR or Southern blot analysis. Subsequent to its use in selection, a selectable marker can be removed from the genome of the host cell by, e.g., Cre-LoxP systems (see, e.g., Gossen et al., 2002, Ann. Rev. Genetics 36:153-173 and U.S. 2006/0014264). Alternatively, a gene replacement vector can be constructed in such a way as to include a portion of the gene to be disrupted, where the portion is devoid of any endogenous gene promoter sequence and encodes none, or an inactive fragment of, the coding sequence of the gene.
(18) As used herein, the terms variant and mutant are used to describe a protein sequence that has been modified at one or more amino acids, compared to the wild type sequence of a particular protein.
(19) As used herein, the term inactive fragment is a fragment of the gene that encodes a protein having, e.g., less than about 10% (e.g., less than about 9%, less than about 8%, less than about 7%, less than about 6%, less than about 5%, less than about 4%, less than about 3%, less than about 2%, less than about 1%, or 0%) of the activity of the protein produced from the full-length coding sequence of the gene. Such a portion of a gene is inserted in a vector in such a way that no known promoter sequence is operably linked to the gene sequence, but that a stop codon and a transcription termination sequence are operably linked to the portion of the gene sequence. This vector can be subsequently linearized in the portion of the gene sequence and transformed into a cell. By way of single homologous recombination, this linearized vector is then integrated in the endogenous counterpart of the gene with inactivation thereof.
(20) As used herein, the term steviol glycoside refers to rebaudioside A (RebA) (CAS #58543-16-1), rebaudioside B (RebB) (CAS #58543-17-2), rebaudioside C (RebC) (CAS #63550-99-2), rebaudioside D (RebD) (CAS #63279-13-0), rebaudioside E (RebE) (CAS #63279-14-1), rebaudioside F (RebF) (CAS #438045-89-7), rebaudioside M (RebM) (CAS #1220616-44-3), rubusoside (CAS #63849-39-4), dulcoside A (CAS #64432-06-0), rebaudioside I (RebI) (MassBank Record: FU000332), rebaudioside Q (RebQ), 1,2-stevioside (CAS #57817-89-7), 1,3-stevioside (RebG), 1,2-bioside (MassBank Record: FU000299), 1,3-bioside, steviol-13-O-glucoside (13-SMG), steviol-19-O-glucoside (19-SMG), a tri-glucosylated steviol glycoside, a tetra-glycosylated steviol glycoside, a penta-glucosylated steviol glycoside, a hexa-glucosylated steviol glycoside, a hepta-glucosylated steviol glycoside, and isomers thereof. See
(21) As used herein, the terms steviol glycoside precursor and steviol glycoside precursor compound are used to refer to intermediate compounds in the steviol glycoside biosynthetic pathway. Steviol glycoside precursors include, but are not limited to, geranylgeranyl diphosphate (GGPP), ent-copalyl-diphosphate, ent-kaurene, ent-kaurenol, ent-kaurenal, ent-kaurenoic acid, and steviol. In some embodiments, steviol glycoside precursors are themselves steviol glycoside compounds. For example, 19-SMG, rubusoside, stevioside, and RebE are steviol glycoside precursors of RebM. See
(22) Recombinant steviol glycoside-producing Saccharomyces cerevisiae (S. cerevisiae) strains are described in WO 2011/153378, WO 2013/022989, WO 2014/122227, and WO 2014/122328, each of which has been incorporated by reference herein in its entirety. Methods of producing steviol glycosides in recombinant hosts, by whole cell bio-conversion, and in vitro are also described in WO 2011/153378, WO 2013/022989, WO 2014/122227, and WO 2014/122328.
(23) In some embodiments, steviol glycosides and/or steviol glycoside precursors are produced in vivo through expression of one or more enzymes involved in the steviol glycoside biosynthetic pathway in a recombinant host. For example, a steviol-producing recombinant host expressing one or more of a gene encoding a geranylgeranyl diphosphate synthase (GGPPS) polypeptide, a gene encoding an ent-copalyl diphosphate synthase (CDPS) polypeptide, a gene encoding a kaurene synthase (KS) polypeptide, a gene encoding a kaurene oxidase polypeptide (KO), a gene encoding a steviol synthase (KAH) polypeptide, a gene encoding a cytochrome P450 reductase (CPR) polypeptide, and a gene encoding a UGT polypeptide can produce a steviol glycoside and/or steviol glycoside precursors in vivo. See Examples 1-4.
(24) In another example, a recombinant host expressing a gene encoding a GGPPS polypeptide, a gene encoding a CDPS polypeptide, a gene encoding a KS polypeptide, a gene encoding a KO polypeptide, a gene encoding a KAH polypeptide, and a gene encoding a CPR polypeptide can produce steviol in vivo. The skilled worker will appreciate that one or more of these genes can be endogenous to the host provided that at least one (and in some embodiments, all) of these genes is a recombinant gene introduced into the recombinant host.
(25) In another example, a recombinant host expressing a gene encoding a GGPPS polypeptide, a gene encoding a CDPS polypeptide, a gene encoding a KS polypeptide, a gene encoding a KO polypeptide, a gene encoding a KAH polypeptide, a gene encoding a CPR polypeptide, and one or more of a gene encoding a UGT polypeptide can produce a steviol glycoside in vivo. The skilled worker will appreciate that one or more of these genes can be endogenous to the host provided that at least one (and in some embodiments, all) of these genes is a recombinant gene introduced into the recombinant host.
(26) In some aspects, the GGPPS polypeptide comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:208 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:207), SEQ ID NO:210 (encoded by the nucleotide sequence set forth in SEQ ID NO:209), SEQ ID NO:212 (encoded by the nucleotide sequence set forth in SEQ ID NO:211), SEQ ID NO:214 (encoded by the nucleotide sequence set forth in SEQ ID NO:213), SEQ ID NO:216 (encoded by the nucleotide sequence set forth in SEQ ID NO:215), SEQ ID NO:218 (encoded by the nucleotide sequence set forth in SEQ ID NO:217), SEQ ID NO:182 (encoded by the nucleotide sequence set forth in SEQ ID NO:181), or SEQ ID NO:220 (encoded by the nucleotide sequence set forth in SEQ ID NO:219).
(27) In some aspects, the CDPS polypeptide comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:222 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:221), SEQ ID NO:224 (encoded by the nucleotide sequence set forth in SEQ ID NO:223), SEQ ID NO:226 (encoded by the nucleotide sequence set forth in SEQ ID NO:225), SEQ ID NO:228 (encoded by the nucleotide sequence set forth in SEQ ID NO:227), or SEQ ID NO:230 (encoded by the nucleotide sequence set forth in SEQ ID NO:229). In some embodiments, the CDPS polypeptide lacks a chloroplast transit peptide. For example, the CDPS polypeptide lacking a chloroplast transit polypeptide can comprise a polypeptide having an amino acid sequence set forth in SEQ D NO:184 (encoded by the nucleotide sequence set forth in SEQ ID NO:183).
(28) In some aspects, the KS polypeptide comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:232 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:231), SEQ ID NO:234 (encoded by the nucleotide sequence set forth in SEQ ID NO:233), SEQ ID NO:236 (encoded by the nucleotide sequence set forth in SEQ ID NO:235), SEQ ID NO:238 (encoded by the nucleotide sequence set forth in SEQ ID NO:237), or SEQ ID NO:186 (encoded by the nucleotide sequence set forth in SEQ ID NO:185).
(29) In some embodiments, a recombinant host comprises a gene encoding a CDPS-KS polypeptide. In some aspects, the CDPS-KS polypeptide comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:240 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:239), SEQ ID NO:242 (encoded by the nucleotide sequence set forth in SEQ ID NO:241), or SEQ ID NO:244 (encoded by the nucleotide sequence set forth in SEQ ID NO:243).
(30) In some aspects, the KO polypeptide comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:188 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:187), SEQ ID NO:246 (encoded by the nucleotide sequence set forth in SEQ ID NO:245), SEQ ID NO:249 (encoded by the nucleotide sequence set forth in SEQ ID NO:247 or SEQ ID NO:248), SEQ ID NO:251 (encoded by the nucleotide sequence set forth in SEQ ID NO:250), SEQ ID NO:253 (encoded by the nucleotide sequence set forth in SEQ ID NO:252), SEQ ID NO:255 (encoded by the nucleotide sequence set forth in SEQ ID NO:254), SEQ ID NO:257 (encoded by the nucleotide sequence set forth in SEQ ID NO:256), SEQ ID NO:259 (encoded by the nucleotide sequence set forth in SEQ ID NO:258), or SEQ ID NO:261 (encoded by the nucleotide sequence set forth in SEQ ID NO:260).
(31) In some aspects, the CPR polypeptide comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:263 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:262), SEQ ID NO:265 (encoded by the nucleotide sequence set forth in SEQ ID NO:264), SEQ ID NO:287 (encoded by the nucleotide sequence set forth in SEQ ID NO:286), SEQ ID NO:289 (encoded by the nucleotide sequence set forth in SEQ ID NO:288), SEQ ID NO:194 (encoded by the nucleotide sequence set forth in SEQ ID NO:193), SEQ ID NO:291 (encoded by the nucleotide sequence set forth in SEQ ID NO:290), SEQ ID NO:293 (encoded by the nucleotide sequence set forth in SEQ ID NO:292), or SEQ ID NO:190 (encoded by the nucleotide sequence set forth in SEQ ID NO:189).
(32) In some aspects, the KAH polypeptide comprises a polypeptide having an amino acid sequence set forth in SEQ ID NO:192 (which can be encoded by the nucleotide sequence set forth in SEQ ID NO:191), SEQ ID NO:266 (encoded by the nucleotide sequence set forth in SEQ ID NO:294 or SEQ ID NO:295), SEQ ID NO:269 (encoded by the nucleotide sequence set forth in SEQ ID NO:267 or SEQ ID NO:268), SEQ ID NO:270, SEQ ID NO:271, SEQ ID NO:272, SEQ ID NO:273, SEQ ID NO:275 (encoded by the nucleotide sequence set forth in SEQ ID NO:274), SEQ ID NO:277 (encoded by the nucleotide sequence set forth in SEQ ID NO:276), SEQ ID NO:279 (encoded by the nucleotide sequence set forth in SEQ ID NO:278), SEQ ID NO:281 (encoded by the nucleotide sequence set forth in SEQ ID NO:280), or SEQ ID NO:283 (encoded by the nucleotide sequence set forth in SEQ ID NO:282).
(33) In some embodiments, a recombinant host comprises a nucleic acid encoding a UGT85C2 polypeptide (SEQ ID NO:195, SEQ ID NO:196), a nucleic acid encoding a UGT76G1 polypeptide (SEQ ID NO:199, SEQ ID NO:200), a nucleic acid encoding a UGT74G1 polypeptide (SEQ ID NO:197, SEQ ID NO:198), a nucleic acid encoding a UGT91D2 polypeptide (i.e., UGT91D2e of SEQ ID NO:284, SEQ ID NO:285 or UGT91D2e-b of SEQ ID NO:201, SEQ ID NO:202), and/or a nucleic acid encoding a EUGT11 polypeptide (SEQ ID NO:203, SEQ ID NO:204). The skilled worker will appreciate that expression of these genes may be necessary to produce a particular steviol glycoside but that one or more of these genes can be endogenous to the host provided that at least one (and in some embodiments, all) of these genes is a recombinant gene introduced into the microorganism. In a particular embodiment, a steviol-producing recombinant microorganism comprises exogenous nucleic acids encoding UGT85C2, UGT76G1, or UGT91D2 polypeptides. In another particular embodiment, a steviol-producing recombinant microorganism comprises exogenous nucleic acids encoding UGT85C2, UGT76G1, UGT74G1, and UGT91D2 polypeptides. In yet another particular embodiment, a steviol-producing recombinant microorganism comprises exogenous nucleic acids encoding UGT85C2, UGT76G1, UGT74G1, and EUGT11 polypeptides. In yet another particular embodiment, a steviol-producing recombinant microorganism comprises the exogenous nucleic acids encoding UGT85C2, UGT76G1, UGT74G1, UGT91D2 (including inter alia 91D2e, 91D2m, 91D2e-b, and functional homologs thereof), and EUGT11 polypeptides. See Examples 1-4.
(34) In certain embodiments, the steviol glycoside is RebA, RebB, RebD, and/or RebM. RebA can be synthesized in a steviol-producing recombinant microorganism expressing UGT85C2, UGT76G1, UGT74G1, and UGT91D2. RebB can be synthesized in a steviol-producing recombinant microorganism expressing UGT85C2, UGT76G1, and UGT91D2. RebD can be synthesized in a steviol-producing recombinant microorganism expressing UGT85C2, UGT76G1 UGT74G1, and UGT91D2 and/or EUGT11. RebM can be synthesized in a steviol-producing recombinant microorganism expressing UGT85C2, UGT76G1, UGT74G1, and UGT91D2 and/or EUGT11 (see
(35) In some embodiments, steviol glycosides and/or steviol glycoside precursors are produced through contact of a steviol glycoside precursor with one or more enzymes involved in the steviol glycoside pathway in vitro. For example, contacting steviol with a UGT polypeptide can result in production of a steviol glycoside in vitro. In some embodiments, a steviol glycoside precursor is produced through contact of an upstream steviol glycoside precursor with one or more enzymes involved in the steviol glycoside pathway in vitro. For example, contacting ent-kaurenoic acid with a KAH enzyme can result in production of steviol in vitro.
(36) In some embodiments, a steviol glycoside or steviol glycoside precursor is produced by whole cell bioconversion. For whole cell bioconversion to occur, a host cell expressing one or more enzymes involved in the steviol glycoside pathway takes up and modifies a steviol glycoside precursor in the cell; following modification in vivo, a steviol glycoside remains in the cell and/or is excreted into the culture medium. For example, a host cell expressing a gene encoding a UGT polypeptide can take up steviol and glycosylate steviol in the cell; following glycosylation in vivo, a steviol glycoside can be excreted into the culture medium. In some embodiments, the cell is permeabilized to take up a substrate to be modified or to excrete a modified product.
(37) In some embodiments, a steviol glycoside or steviol glycoside precursor composition produced in vivo, in vitro, or by whole cell bioconversion does not comprise or comprises a reduced amount of plant-derived components than a stevia extract from, inter alia, a stevia plant. Plant-derived components can contribute to off-flavors and include pigments, lipids, proteins, phenolics, saccharides, spathulenol and other sesquiterpenes, labdane diterpenes, monoterpenes, decanoic acid, 8,11,14-eicosatrienoic acid, 2-methyloctadecane, pentacosane, octacosane, tetracosane, octadecanol, stigmasterol, -sitosterol, - and -amyrin, lupeol, -amryin acetate, pentacyclic triterpenes, centauredin, quercitin, epi-alpha-cadinol, carophyllenes and derivatives, beta-pinene, beta-sitosterol, and gibberellin. In some embodiments, the plant-derived components referred to herein are non-glycoside compounds.
(38) As used herein, the terms detectable amount, detectable concentration, measurable amount, and measurable concentration refer to a level of steviol glycosides measured in AUC, M/OD.sub.600, mg/L, M, or mM. Steviol glycoside production (i.e., total, supernatant, and/or intracellular steviol glycoside levels) can be detected and/or analyzed by techniques generally available to one skilled in the art, for example, but not limited to, liquid chromatography-mass spectrometry (LC-MS), thin layer chromatography (TLC), high-performance liquid chromatography (HPLC), ultraviolet-visible spectroscopy/spectrophotometry (UV-Vis), mass spectrometry (MS), and nuclear magnetic resonance spectroscopy (NMR).
(39) As used herein, the term undetectable concentration refers to a level of a compound that is too low to be measured and/or analyzed by techniques such as TLC, HPLC, UV-Vis, MS, or NMR. In some embodiments, a compound of an undetectable concentration is not present in a steviol glycoside or steviol glycoside precursor composition.
(40) As used herein, the terms or and and/or is utilized to describe multiple components in combination or exclusive of one another. For example, x, y, and/or z can refer to x alone, y alone, z alone, x, y, and z, (x and y) or z, x or (y and z), or x or y or z. In some embodiments, and/or is used to refer to the exogenous nucleic acids that a recombinant cell comprises, wherein a recombinant cell comprises one or more exogenous nucleic acids selected from a group. In some embodiments, and/or is used to refer to production of steviol glycosides and/or steviol glycoside precursors. In some embodiments, and/or is used to refer to production of steviol glycosides, wherein one or more steviol glycosides are produced. In some embodiments, and/or is used to refer to production of steviol glycosides, wherein one or more steviol glycosides are produced through one or more of the following steps: culturing a recombinant microorganism, synthesizing one or more steviol glycosides in a recombinant microorganism, and/or isolating one or more steviol glycosides.
(41) Functional Homologs
(42) Functional homologs of the polypeptides described above are also suitable for use in producing steviol glycosides in a recombinant host. A functional homolog is a polypeptide that has sequence similarity to a reference polypeptide, and that carries out one or more of the biochemical or physiological function(s) of the reference polypeptide. A functional homolog and the reference polypeptide can be a natural occurring polypeptide, and the sequence similarity can be due to convergent or divergent evolutionary events. As such, functional homologs are sometimes designated in the literature as homologs, or orthologs, or paralogs. Variants of a naturally occurring functional homolog, such as polypeptides encoded by mutants of a wild type coding sequence, can themselves be functional homologs. Functional homologs can also be created via site-directed mutagenesis of the coding sequence for a polypeptide, or by combining domains from the coding sequences for different naturally-occurring polypeptides (domain swapping). Techniques for modifying genes encoding functional polypeptides described herein are known and include, inter alia, directed evolution techniques, site-directed mutagenesis techniques and random mutagenesis techniques, and can be useful to increase specific activity of a polypeptide, alter substrate specificity, alter expression levels, alter subcellular location, or modify polypeptide-polypeptide interactions in a desired manner. Such modified polypeptides are considered functional homologs. The term functional homolog is sometimes applied to the nucleic acid that encodes a functionally homologous polypeptide.
(43) Functional homologs can be identified by analysis of nucleotide and polypeptide sequence alignments. For example, performing a query on a database of nucleotide or polypeptide sequences can identify homologs of steviol glycoside biosynthesis polypeptides. Sequence analysis can involve BLAST, Reciprocal BLAST, or PSI-BLAST analysis of non-redundant databases using a UGT amino acid sequence as the reference sequence. Amino acid sequence is, in some instances, deduced from the nucleotide sequence. Those polypeptides in the database that have greater than 40% sequence identity are candidates for further evaluation for suitability as a steviol glycoside biosynthesis polypeptide. Amino acid sequence similarity allows for conservative amino acid substitutions, such as substitution of one hydrophobic residue for another or substitution of one polar residue for another. If desired, manual inspection of such candidates can be carried out in order to narrow the number of candidates to be further evaluated. Manual inspection can be performed by selecting those candidates that appear to have domains present in steviol glycoside biosynthesis polypeptides, e.g., conserved functional domains. In some embodiments, nucleic acids and polypeptides are identified from transcriptome data based on expression levels rather than by using BLAST analysis.
(44) Conserved regions can be identified by locating a region within the primary amino acid sequence of a steviol glycoside biosynthesis polypeptide that is a repeated sequence, forms some secondary structure (e.g., helices and beta sheets), establishes positively or negatively charged domains, or represents a protein motif or domain. See, e.g., the Pfam web site describing consensus sequences for a variety of protein motifs and domains on the World Wide Web at sanger.ac.uk/Software/Pfam/and pfam.janelia.org/. The information included at the Pfam database is described in Sonnhammer et al., Nucl. Acids Res., 26:320-322 (1998); Sonnhammer et al., Proteins, 28:405-420 (1997); and Bateman et al., Nucl. Acids Res., 27:260-262 (1999). Conserved regions also can be determined by aligning sequences of the same or related polypeptides from closely related species. Closely related species preferably are from the same family. In some embodiments, alignment of sequences from two different species is adequate to identify such homologs.
(45) Typically, polypeptides that exhibit at least about 40% amino acid sequence identity are useful to identify conserved regions. Conserved regions of related polypeptides exhibit at least 45% amino acid sequence identity (e.g., at least 50%, at least 60%, at least 70%, at least 80%, or at least 90% amino acid sequence identity). In some embodiments, a conserved region exhibits at least 92%, 94%, 96%, 98%, or 99% amino acid sequence identity.
(46) For example, polypeptides suitable for producing steviol in a recombinant host include functional homologs of UGTs.
(47) Methods to modify the substrate specificity of, for example, a UGT, are known to those skilled in the art, and include without limitation site-directed/rational mutagenesis approaches, random directed evolution approaches and combinations in which random mutagenesis/saturation techniques are performed near the active site of the enzyme. For example see Osmani et al., 2009, Phytochemistry 70: 325-347.
(48) A candidate sequence typically has a length that is from 80% to 250% of the length of the reference sequence, e.g., 82, 85, 87, 89, 90, 93, 95, 97, 99, 100, 105, 110, 115, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, or 250% of the length of the reference sequence. A functional homolog polypeptide typically has a length that is from 95% to 105% of the length of the reference sequence, e.g., 90, 93, 95, 97, 99, 100, 105, 110, 115, or 120% of the length of the reference sequence, or any range between. A % identity for any candidate nucleic acid or polypeptide relative to a reference nucleic acid or polypeptide can be determined as follows. A reference sequence (e.g., a nucleic acid sequence or an amino acid sequence described herein) is aligned to one or more candidate sequences using the computer program Clustal Omega (version 1.2.1, default parameters), which allows alignments of nucleic acid or polypeptide sequences to be carried out across their entire length (global alignment). Chenna et al., 2003, Nucleic Acids Res. 31(13):3497-500.
(49) Clustal Omega calculates the best match between a reference and one or more candidate sequences, and aligns them so that identities, similarities and differences can be determined. Gaps of one or more residues can be inserted into a reference sequence, a candidate sequence, or both, to maximize sequence alignments. For fast pairwise alignment of nucleic acid sequences, the following default parameters are used: word size: 2; window size: 4; scoring method: % age; number of top diagonals: 4; and gap penalty: 5. For multiple alignment of nucleic acid sequences, the following parameters are used: gap opening penalty: 10.0; gap extension penalty: 5.0; and weight transitions: yes. For fast pairwise alignment of protein sequences, the following parameters are used: word size: 1; window size: 5; scoring method: % age; number of top diagonals: 5; gap penalty: 3. For multiple alignment of protein sequences, the following parameters are used: weight matrix: blosum; gap opening penalty: 10.0; gap extension penalty: 0.05; hydrophilic gaps: on; hydrophilic residues: Gly, Pro, Ser, Asn, Asp, Gln, Glu, Arg, and Lys; residue-specific gap penalties: on. The Clustal Omega output is a sequence alignment that reflects the relationship between sequences. Clustal Omega can be run, for example, at the Baylor College of Medicine Search Launcher site on the World Wide Web (searchlauncher.bcm.tmc.edu/multi-align/multi-align.html) and at the European Bioinformatics Institute site at http://www.ebi.ac.uk/Tools/msa/clustalo/.
(50) To determine a % identity of a candidate nucleic acid or amino acid sequence to a reference sequence, the sequences are aligned using Clustal Omega, the number of identical matches in the alignment is divided by the length of the reference sequence, and the result is multiplied by 100. It is noted that the % identity value can be rounded to the nearest tenth. For example, 78.11, 78.12, 78.13, and 78.14 are rounded down to 78.1, while 78.15, 78.16, 78.17, 78.18, and 78.19 are rounded up to 78.2.
(51) It will be appreciated that functional UGT proteins can include additional amino acids that are not involved in the enzymatic activities carried out by the enzymes. In some embodiments, UGT proteins are fusion proteins. The terms chimera, fusion polypeptide, fusion protein, fusion enzyme, fusion construct, chimeric protein, chimeric polypeptide, chimeric construct, and chimeric enzyme can be used interchangeably herein to refer to proteins engineered through the joining of two or more genes that code for different proteins.
(52) In some embodiments, a nucleic acid sequence encoding a UGT polypeptide can include a tag sequence that encodes a tag designed to facilitate subsequent manipulation (e.g., to facilitate purification or detection), solubility, secretion, or localization of the encoded polypeptide. Tag sequences can be inserted in the nucleic acid sequence encoding the polypeptide such that the encoded tag is located at either the carboxyl or amino terminus of the polypeptide. Non-limiting examples of encoded tags include green fluorescent protein (GFP), human influenza hemagglutinin (HA), glutathione S transferase (GST), polyhistidine-tag (HIS tag), disulfide oxiodoreductase (DsbA), maltose binding protein (MBP), N-utilization substance (NusA), small ubiquitin-like modifier (SUMO), and Flag tag (Kodak, New Haven, Conn.). Other examples of tags include a chloroplast transit peptide, a mitochondrial transit peptide, an amyloplast peptide, signal peptide, or a secretion tag.
(53) In some embodiments, a fusion protein is a protein altered by domain swapping. As used herein, the term domain swapping is used to describe the process of replacing a domain of a first protein with a domain of a second protein. In some embodiments, the domain of the first protein and the domain of the second protein are functionally identical or functionally similar. In some embodiments, the structure and/or sequence of the domain of the second protein differs from the structure and/or sequence of the domain of the first protein. In some embodiments, a UGT polypeptide is altered by domain swapping.
(54) Transporter Expression
(55) This document describes reagents and methods that can be used to efficiently produce steviol glycoside compositions. Modification of transport systems in a recombinant host that are involved in transport of steviol glycosides into culture medium can allow for more effective production of steviol glycosides in recombinant hosts.
(56) As set forth herein, recombinant cells having modifications to cellular transport are capable of producing steviol. Recombinant hosts described herein can produce steviol and have altered expression of at least one endogenous transporter gene. Recombinant hosts described herein can produce steviol and have altered expression of a transcription factor that regulates expression of at least one endogenous transporter gene. Altering expression of endogenous transporter genes can be useful for increasing production of steviol and/or excretion of steviol into the culture medium.
(57) As set forth herein, recombinant cells having modifications to cellular transport are capable of producing at least one steviol glycoside, including, but not limited to, RebA, RebB, RebD, and/or RebM. Recombinant hosts described herein can produce at least one steviol glycoside such as RebA, RebB, RebD, and/or RebM and have altered expression of at least one endogenous transporter gene. Recombinant hosts described herein can produce at least one steviol glycoside such as RebA, RebB, RebD, and/or RebM and have altered expression of a trafficking adapter gene that regulates the stability of at least one endogenous transporter gene. Recombinant hosts described herein can produce at least one steviol glycoside such as RebA, RebB, RebD, and/or RebM and have altered expression of a plurality of endogenous transporter genes and/or of a plurality of trafficking adapter genes that regulate stability of a plurality of endogenous transporter genes. Altering expression of endogenous transporter genes and/or trafficking adapter genes can be useful for increasing production of steviol glycosides and/or excretion of steviol glycosides into the culture medium.
(58) Recombinant hosts disclosed herein can include one or more biosynthesis genes, such as one or more genes encoding a sucrose transporter and a sucrose synthase; a gene encoding a geranylgeranyl diphosphate synthase (GGPPS) polypeptide; a gene encoding an ent-copalyl diphosphate synthase (CDPS) polypeptide; a gene encoding a kaurene synthase (KS) polypeptide; a gene encoding a kaurene oxidase (KO) polypeptide; a gene encoding a steviol synthase (KAH) polypeptide; a gene encoding a cytochrome P450 reductase (CPR) polypeptide; a gene encoding a UGT85C2 polypeptide; a gene encoding a UGT76G1 polypeptide; a gene encoding a UGT74G1 polypeptide; a gene encoding a UGT91D2 functional homolog; and/or a gene encoding a EUGT11 polypeptide; wherein expression of one or more of these genes results in production of steviol glycosides such as RebA, RebB, RebD, and/or RebM.
(59) As used herein, the terms transport of a steviol glycoside, steviol glycoside transport, excretion of a steviol glycoside, and steviol glycoside excretion can be used interchangeably.
(60) As used herein, the term transporter (also referred to as a membrane transport protein) refers to a membrane protein involved in the movement of small molecules, macromolecules (such as carbohydrates), and ions across a biological membrane. Transporters span the membrane in which they are localized and across which they transport substances. Transporter proteins can assist in the movement (i.e., transport or excretion) of a substance from the intracellular space to the culture medium. Transporters are known to function as passive transport systems, carrying molecules down their concentration gradient, or as active transport systems, using energy to carry molecules uphill against their concentration gradient. Active transport is mediated by carriers which couple transport directly to the use of energy derived from hydrolysis of an ATP molecule or by carriers which make use of a pre-established electrochemical ion gradient to drive co-transport of the nutrient molecule and a co-transported ion. The latter category comprises symporters and antiporters, which carry the ion in the same or opposite direction, respectively, as the transported substrate.
(61) Transport proteins have been classified according to various criteria at the Transporter Classification Database (on the world wide web at tcdb.org). See, Saier Jr. et al., Nucl. Acids Res., 42(1):D251-258 (2014). Non-limiting examples thereof include, among others, the family of Multiple Drug Resistance (MDR) plasma membrane transporters that is thought to be ubiquitous among living organisms. The MDR transporter superfamily can be further subdivided according to the mode of operation by which the substrate is transported from one side of the membrane to the other. Transporters can operate to move substances across membranes in response to chemiosmotic ion gradients or by active transport. ATP-binding cassette transporters (ABC transporters) are transmembrane proteins that utilize the energy of adenosine triphosphate (ATP) hydrolysis to carry out translocation of various substrates across membranes. They can transport a wide variety of substrates across the plasma membrane and intracellular membranes, including metabolic products, lipids and sterols, and drugs. Particular non-limiting examples of endogenous ABC transporter genes include PDR5, YDR061W, PDR15, SNQ2, YOR1, YOL075C, MDL2, ADP1, CAF16, VMR1 and STE6 (or a functional homolog thereof). In some aspects, ABC transporters transport steviol glycosides.
(62) A second group of MDRs is further subdivided based on the nature of the chemiosmotic gradient that facilitates the transport. Saier, Jr. et al., J. Mol. Microbiol. Biotechnol. 1:257-279 (1999). In some aspects, MDR transporters transport steviol glycosides.
(63) Another transporter family, the Major Facilitator Superfamily (MFS) transporters are monomeric polypeptides that can transport small solutes in response to proton gradients. The MFS transporter family is sometimes referred to as the uniporter-symporter-antiporter family. MFS transporters function in, inter alia, in sugar uptake and drug efflux systems. MFS transporters typically comprise conserved MFS-specific motifs. Non-limiting examples of endogenous MFS transporter genes include DTR1, SEO1, YBR241C, VBA3, FEN2, SNF3, STL1, HXT10, AZR1, MPH3, VBA5, GEX2, SNQ1, AQR1, MCH1, MCH5, ATG22, HXT15, MPH2, ITR1, SIT1, VPS73, HXT5, QDR1, QDR2, QDR3, SOA1, HXT9, YMR279C, YIL166C, HOL1, ENB1, TPO4 and FLR1 (or a functional homolog thereof). In some aspects, MFS transporters transport steviol glycosides. In some embodiments, PDR5, PDR15, SNQ2, or YOR1 transport kaurenoic acid, steviol, and/or steviol monosides.
(64) Other transporter families include the SMR (small multidrug resistant) family, RND (Resistance-Nodulation-Cell Division) family, and the MATE (multidrug and toxic compound extrusion) family. The SMR family members are integral membrane proteins characterized by four alpha-helical transmembrane strands that confer resistance to a broad range of antiseptics, lipophilic quaternary ammonium compounds (QAC), and aminoglycoside resistance in bacteria. See, Bay & Turner, 2009, BMC Evol Biol., 9:140. In some aspects, SMR transporters transport steviol glycosides.
(65) The MATE family members comprise 12 transmembrane (TM) domains. Members of the MATE family have been identified in prokaryotes, yeast such as S. cerevisiae and Schizosaccharomyces pombe, and plants. See Diener et al., 2001, Plant Cell. 13(7):1625-8. The MATE family members are sodium or proton antiporters. In some aspects, MATE transporters transport steviol glycosides.
(66) Additional transporter families include the amino acid/auxin permease (AAAP) family (for example, YKL146W/AVT3, YBL089W/AVT5, YER119C/AVT6 and YIL088C/AVT7), ATPase family (for example, YBL099W/ATP1, YDL185W/VMA1, YLR447C/VMA6, YOL077W/ATP19, YPL078C/ATP4, YEL027W/VMA3, YKL016C/ATP7, and YOR332W/VMA4), sulfate permease (SuIP) family (for example, YBR294W/SUL1, YGR125W and YPR003C), lysosomal cystine transporter (LCT) family (for example, YCR075C/ERS1), the Ca2+:cation antiporter (CaCA) family (for example, YDL128W/VCX1 and YJR106W/ECM27), the amino acid-polyamine-organocation (APC) superfamily (for example, YDL210W/UGA4, YOL020W/TAT2, YPL274W/SAM3, YNL268W/LYP1, YHL036W/MUP3, YKR039W/GAP1 and YOR348C/PUT4), multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) (for example, YDR338C), ZRT/IRT-like protein (ZIP) metal transporter family (for example, YGL225W/ZRT1 and YOR079C/ATX2), the mitochondrial protein translocase (MPT) family (for example, YGR181W/TIM13, YNL070W/TOM7, YNL121C/TOM70, the voltage-gated ion channel (VIC) family (for example, YGR217W/CCH1 and YJL093C/TOK1), the monovalent cation:proton antiporter-2 (CPA2) family (for example, YJL094C/KHA1), the ThrE family of putative transmembrane amino acid efflux transporters (for example, YJL108C/PRM10), the oligopeptide transporter (OPT) family (for example, YJL212C/OPT1 and YGL114W), the K.sup.+ transporter (Trk) family (for example, TKR050W/TRK2), the bile acid:Na symporter (BASS) family (for example, YMR034C), the drug/metabolite transporter (DMT) superfamily (for example, YMR253C, YML038C/YMD8, and YOR307C/SLY41), the mitochondrial carrier (MC) family (for example, YMR056C/AAC1, YNL083W/SAL1, YOR130C/ORT1, YOR222W/ODC2, YPR011C, YPR058W/YMC1, YPR128C/ANT1, YEL006W/YEA6, YER053C/PIC2, YFR045W, YGR257C/MTM1, YHR002W/LEU5, YIL006W/YIA6, YJL133W/MRS3, YKL120W/OAC1, YMR166C, YNL003C/PET8 and YOR100C/CRC1), the auxin efflux carrier (AEC) family (for example, YNL095C, YOR092W/ECM3 and YBR287W), the ammonia channel transporter (Amt) family (for example, YNL142W/MEP2), the metal ion (Mn.sup.2+-iron) transporter (Nramp) family (for example, YOL122C/SMF1), the transient receptor potential Ca.sup.2+ channel (TRP-CC) family (for example, YOR087W/YVC1), the arsenical resistance-3 (ACR3) family (for example, YPR201W/ARR3), the nucleobase:cation symporter-1 (NCS1) family (for example, YBR021W/FUR4), the inorganic phosphate transporter (PiT) family (for example, YBR296C/PHO89), the arsenite-antimonite (ArsAB) efflux family (for example, YDL100C/GET3), the IISP family of transporters, the glycerol uptake (GUP) family (for example, YGL084C/GUP1), the metal ion transport (MIT) family (for example, YKL064W/MNR2, YKL050C and YOR334W/MRS2), the copper transport (Ctr) family (for example, YLR411W/CTR3) and the cation diffusion facilitator (CDF) family (for example, YOR316C/COT1). Particular members of any of these transporter families are included within the scope of the disclosed invention to the extent that altered expression in a cell capable of producing steviol glycoside increases production and/or excretion of said steviol glycoside.
(67) Methods for identifying a gene affecting production or transport of steviol glycosides and steviol glycoside pathway intermediates are disclosed herein. Such methods can involve inactivating at least one endogenous transporter gene or modifying expression of at least one transporter gene. Typically, a library of mutant microorganisms is prepared, each mutant in the library having a different endogenous transporter gene inactivated. Methods of inactivating genes and determining their effect in a microorganims are known to a person having ordinary skill in the art; additional methods are disclosed in WO 2014/122328, the disclosure of which is incorporated by reference in its entirety. The mutant microorganisms comprising one or more steviol glycoside pathway genes are cultured in a medium under conditions in which steviol or a steviol glycoside is synthesized, and the amount of total, supernatant, and/or intracellular steviol glycosides produced by the microorganism is measured (e.g., using LC-MS) as described herein.
(68) The disclosure is directed to recombinant host cells in which expression of an endogenous transporter gene or trafficking adapter gene is modified. In some embodiments, the transporter or trafficking adapter gene is endogenous to S. cerevisiae, including, but not limited to S. cerevisiae strain S288C. In some embodiments, expression of an endogenous transporter or trafficking adapter can be modified by replacing the endogenous promoter with a different promoter that results in increased expression of the transporter protein (e.g., at least a 5% increase in expression, such as at least a 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50%, 100%, 200% increase or more in expression). For example, an endogenous promoter can be replaced with a constitutive or inducible promoter that results in increased expression of the transporter. See, e.g., Partow et al., 2010, Yeast 27:955-64. Homologous recombination can be used to replace the promoter of an endogenous gene with a different promoter that results in increased expression of the transporter. In other embodiments, the inducible or constitutive promoter and endogenous transporter or trafficking adapter can be integrated into another locus of the genome using homologous recombination. In other embodiments, the transporter or trafficking adapter gene can be introduced into a microorganism using exogenous plasmids with a promoter that results in overexpression of the transporter or trafficking adapter in the microorganim. In yet another embodiment, the exogenous plasmids may also comprise multiple copies of the transporter or trafficking adapter gene. In a further embodiment, the endogenous transporter or trafficking adapter can be induced to be overexpressed using native mechanisms to the recombinant microorganism (e.g. heat shock, stress, heavy metal, or antibiotic exposure). In yet a further embodiment, the activity of an endogenous gene product is enhanced or increased (for example, by mutation). In yet another embodiment, a homologous or orthologous gene of an endogenous yeast transporter or trafficking adapter factor gene is overexpressed.
(69) As used herein, the term modified expression of a transporter gene refers to a deletion of an endogenous gene encoding a transporter polypeptide, expression or overexpression of a gene encoding a Sugar Efflux Transporter (SET) transporter polypeptide, expression or overexpression of a gene encoding a SWEET transporter polypeptide, deletion or overexpression of a gene encoding a trafficking adapter polypeptide, expression or overexpression of an endogenous gene encoding a transporter polypeptide, or expression or overexpression of a heterologous gene encoding a transporter polypeptide.
(70) In some embodiments, a steviol glycoside-producing host is transformed with a SET (sugar efflux transporter) or SWEET transporter. See, e.g., Chen et al., Sugar transporters for intercellular exchange and nutrition of pathogens, Nature 468(7323):527-32 (2010) and Sun & Vanderpool, Regulation and Function of Escherichia coli Sugar Efflux Transporter A (SetA) during Glucose-Phosphate Stress, Journal of Bacteriology 193(1):143-53 (2011). In some embodiments, the SET transporter is SetA from E. coli (SEQ ID NO:17, SEQ ID NO:18) (wherein the first SEQ ID NO sets forth the nucleic acid sequence of the gene and the second sets forth the deduced amino acid sequence of the encoded polypeptide), SetB from E. coli (SEQ ID NO:19, SEQ ID NO:20), or SetC from E. coli (SEQ ID NO:21, SEQ ID NO:22). In some embodiments, the SWEET transporter is SWEET from Brassica rapa (SEQ ID NO:23, SEQ ID NO:24), SWEET from Petuniahybrid (SEQ ID NO:25, SEQ ID NO:26), or SWEET from Triticum urartu (SEQ ID NO:27, SEQ ID NO:28). In some embodiments, expression of a SET or SWEET transporter in a steviol glycoside-producing host results in improved excretion of a steviol glycoside such as RebA, RebB, RebD, or RebM. See Example 2.
(71) In some embodiments, a transporter gene is knocked out of a steviol glycoside-producing host to decrease 13-SMG excretion. In some embodiments, the decrease in 13-SMG secretion results in an increase in production of steviol glycosides such as RebD and RebM. In some embodiments, the knocked out transporter gene is YOR087W (SEQ ID NO:1, SEQ ID NO:2), YML038C (SEQ ID NO:3, SEQ ID NO:4), YJR135W-A (SEQ ID NO:5, SEQ ID NO:6), YDR406W (SEQ ID NO:7, SEQ ID NO:8), YIR028W (SEQ ID NO:9, SEQ ID NO:10), YGR138C (SEQ ID NO:11, SEQ ID NO:12), YJL214W (SEQ ID NO:13, SEQ ID NO:14), or YDR345C (SEQ ID NO:15, SEQ ID NO:16). In some embodiments, deletion of one of YOR087W (SEQ ID NO:1, SEQ ID NO:2), YML038C (SEQ ID NO:3, SEQ ID NO:4), YJR135W-A (SEQ ID NO:5, SEQ ID NO:6), YDR406W (SEQ ID NO:7, SEQ ID NO:8), YIR028W (SEQ ID NO:9, SEQ ID NO:10), YGR138C (SEQ ID NO:11, SEQ ID NO:12), YJL214W (SEQ ID NO:13, SEQ ID NO:14), or YDR345C (SEQ ID NO:15, SEQ ID NO:16) results in a reduction of 13-SMG excretion by up to 70%. See Example 1.
(72) In some embodiments, trafficking adapter proteins (also referred to herein as adapter proteins) are knocked out of a steviol glycoside-producing host. Adapter proteins are involved in regulation of protein trafficking, protein translocation, gene expression, and endocytosis. See, e.g., Lin et al., 2008, Cell 135(4):714-25; Nikko & Pelham, 2009, Traffic 10(12):1856-67; and Nikko et al., 2008, EMBO Rep. 9(12):1216-21. In some aspects, deletion of a gene encoding an adapter protein results in stabilization of a transporter protein or prevents or slows degradation of a transporter protein. In some aspects, one or a plurality of genes encoding one or a plurality of adapter proteins are deleted. In some embodiments, the adapter protein is Art1 (SEQ ID NO:31, SEQ ID NO:32), Art2 (SEQ ID NO:34), Art3 (SEQ ID NO:35, SEQ ID NO:36), Art4 (SEQ ID NO:37, SEQ ID NO:38), Art6 (SEQ ID NO:39, SEQ ID NO:40), Art7 (SEQ ID NO:41, SEQ ID NO:42), Art8 (SEQ ID NO:43, SEQ ID NO:44), Art9 (SEQ ID NO:165, SEQ ID NO:166), Art10 (SEQ ID NO:29, SEQ ID NO:30), Bul1 (SEQ ID NO:45, SEQ ID NO:46), Bul2 (SEQ ID NO:47, SEQ ID NO:48), Tre1 (SEQ ID NO:173, SEQ ID NO:174), Ear1 (SEQ ID NO:169, SEQ ID NO:170), Ssh4 (SEQ ID NO:171, SEQ ID NO:172), or Bsd2 (SEQ ID NO:167, SEQ ID NO:168). See Example 3.
(73) In some embodiments, deletion of Art1 (SEQ ID NO:31, SEQ ID NO:32), Art2 (SEQ ID NO:33, SEQ ID NO:34), Art3 (SEQ ID NO:35, SEQ ID NO:36), Art6 (SEQ ID NO:39, SEQ ID NO:40), Art7 (SEQ ID NO:41, SEQ ID NO:42), Art8 (SEQ ID NO:43, SEQ ID NO:44), Art9 (SEQ ID NO:165, SEQ ID NO:166), Art10 (SEQ ID NO:29, SEQ ID NO:30), Bul1 (SEQ ID NO:45, SEQ ID NO:46), Tre1 (SEQ ID NO:173, SEQ ID NO:174), Ear1 (SEQ ID NO:169, SEQ ID NO:170), Ssh4 (SEQ ID NO:171, SEQ ID NO:172), or Bsd2 (SEQ ID NO:167, SEQ ID NO:168) increases excretion of 13-SMG. See Example 3.
(74) In some embodiments, deletion of Art1 (SEQ ID NO:31, SEQ ID NO:32), Art2 (SEQ ID NO:33, SEQ ID NO:34), Art3 (SEQ ID NO:35, SEQ ID NO:36), Art4 (SEQ ID NO:37, SEQ ID NO:38), Art6 (SEQ ID NO:39, SEQ ID NO:40), Art7 (SEQ ID NO:41, SEQ ID NO:42), Art8 (SEQ ID NO:43, SEQ ID NO:44), Art9 (SEQ ID NO:165, SEQ ID NO:166), Art10 (SEQ ID NO:29, SEQ ID NO:30), Bul1 (SEQ ID NO:45, SEQ ID NO:46), Bul2 (SEQ ID NO:47, SEQ ID NO:48), Tre1 (SEQ ID NO:173, SEQ ID NO:174), Ear1 (SEQ ID NO:169, SEQ ID NO:170), or Ssh4 (SEQ ID NO:171, SEQ ID NO:172) increases excretion of RebA. See Example 3.
(75) In some embodiments, deletion of Art1 (SEQ ID NO:31, SEQ ID NO:32), Art2 (SEQ ID NO:33, SEQ ID NO:34), Art3 (SEQ ID NO:35, SEQ ID NO:36), Art4 (SEQ ID NO:37, SEQ ID NO:38), Art6 (SEQ ID NO:39, SEQ ID NO:40), Art7 (SEQ ID NO:41, SEQ ID NO:42), Art8 (SEQ ID NO:43, SEQ ID NO:44), Art9 (SEQ ID NO:165, SEQ ID NO:166), Art10 (SEQ ID NO:29, SEQ ID NO:30), Bul1 (SEQ ID NO:45, SEQ ID NO:46), Bul2 (SEQ ID NO:47, SEQ ID NO:48), Tre1 (SEQ ID NO:173, SEQ ID NO:174), Ear1 (SEQ ID NO:169, SEQ ID NO:170), Ssh4 (SEQ ID NO:171, SEQ ID NO:172), or Bsd2 (SEQ ID NO:167, SEQ ID NO:168) increases excretion of RebB. See Example 3.
(76) In some embodiments, deletion of Art3 (SEQ ID NO:35, SEQ ID NO:36), Art7 (SEQ ID NO:41, SEQ ID NO:42), Art9 (SEQ ID NO:165, SEQ ID NO:166), Art10 (SEQ ID NO:29, SEQ ID NO:30), or Bul1 (SEQ ID NO:45, SEQ ID NO:46) increases excretion of RebD. See Example 3.
(77) In some embodiments, deletion of Art1 (SEQ ID NO:31, SEQ ID NO:32), Art2 (SEQ ID NO:33, SEQ ID NO:34), Art3 (SEQ ID NO:35, SEQ ID NO:36), Art4 (SEQ ID NO:37, SEQ ID NO:38), Art6 (SEQ ID NO:39, SEQ ID NO:40), Art7 (SEQ ID NO:41, SEQ ID NO:42), Art8 (SEQ ID NO:43, SEQ ID NO:44), Art9 (SEQ ID NO:165, SEQ ID NO:166), Art10 (SEQ ID NO:29, SEQ ID NO:30), Bul1 (SEQ ID NO:45, SEQ ID NO:46), Bul2 (SEQ ID NO:47, SEQ ID NO:48), Tre1 (SEQ ID NO:173, SEQ ID NO:174, Ear1 (SEQ ID NO:169, SEQ ID NO:170), or Ssh4 (SEQ ID NO:171, SEQ ID NO:172) increases excretion of RebA. See Example 3.
(78) In some embodiments, overexpression of Art1 (SEQ ID NO:31, SEQ ID NO:32), Art2 (SEQ ID NO:33, SEQ ID NO:34), Art3 (SEQ ID NO:35, SEQ ID NO:36), Art6 (SEQ ID NO:39, SEQ ID NO:40), Art7 (SEQ ID NO:41, SEQ ID NO:42), Art8 (SEQ ID NO:43, SEQ ID NO:44), Art9 (SEQ ID NO:165, SEQ ID NO:166), Art10 (SEQ ID NO:29, SEQ ID NO:30), Bul1 (SEQ ID NO:45, SEQ ID NO:46), Tre1 (SEQ ID NO:173, SEQ ID NO:174), Ear1 (SEQ ID NO:169, SEQ ID NO:170), Ssh4 (SEQ ID NO:171, SEQ ID NO:172), or Bsd2 (SEQ ID NO:167, SEQ ID NO:168) or deletion of Art4 (SEQ ID NO:37, SEQ ID NO:38) or Bul2 (SEQ ID NO:47, SEQ ID NO:48) decreases excretion of 13-SMG. In some embodiments, overexpression of Art1 (SEQ ID NO:31, SEQ ID NO:32), Art2 (SEQ ID NO:33, SEQ ID NO:34), Art3 (SEQ ID NO:35, SEQ ID NO:36), Art6 (SEQ ID NO:39, SEQ ID NO:40), Art7 (SEQ ID NO:41, SEQ ID NO:42), Art8 (SEQ ID NO:43, SEQ ID NO:44), Art9 (SEQ ID NO:165, SEQ ID NO:166), Art10 (SEQ ID NO:29, SEQ ID NO:30), Bul1 (SEQ ID NO:45, SEQ ID NO:46), Tre1 (SEQ ID NO:173, SEQ ID NO:174), Ear1 (SEQ ID NO:169, SEQ ID NO:170), Ssh4 (SEQ ID NO:171, SEQ ID NO:172), or Bsd2 (SEQ ID NO:167, SEQ ID NO:168) or deletion of Art4 (SEQ ID NO:37, SEQ ID NO:38) or Bul2 (SEQ ID NO:47, SEQ ID NO:48) increases production of RebA, RebB, RebD, and/or RebM.
(79) In other embodiments, the adapter protein is Art5 (SEQ ID NO:163 SEQ ID NO:164) or Tre2 (SEQ ID NO:175, SEQ ID NO:176).
(80) In some embodiments, deletion of a transporter gene in a steviol glycoside-producing host results in improved production of steviol glycosides. In some embodiments, the transporter deletion does not alter steviol glycoside excretion activity. In some embodiments, the deleted transporter gene that improves steviol glycoside production is YBR068C (SEQ ID NO:63, SEQ ID NO:64), YBR220C (SEQ ID NO:65, SEQ ID NO:66), YBR235W (SEQ ID NO:67, SEQ ID NO:68), YBR293W (SEQ ID NO:69, SEQ ID NO:70), YBR298C (SEQ ID NO:71, SEQ ID NO:72), YCR011C (SEQ ID NO:73, SEQ ID NO:74), YCR023C (SEQ ID NO:75, SEQ ID NO:76), YDL100C (SEQ ID NO:77, SEQ ID NO:78), YDL119C (SEQ ID NO:79, SEQ ID NO:80), YDL138W (SEQ ID NO:81, SEQ ID NO:82), YDL199C (SEQ ID NO:83, SEQ ID NO:84), YDL210W (SEQ ID NO:85, SEQ ID NO:86), YDL245C (SEQ ID NO:87, SEQ ID NO:88), YDR061W (SEQ ID NO:89, SEQ ID NO:90), YDR135C (SEQ ID NO:91, SEQ ID NO:92), YDR508C (SEQ ID NO:93, SEQ ID NO:94), YEL006W (SEQ ID NO:95, SEQ ID NO:96), YFL028C (SEQ ID NO:97, SEQ ID NO:98), YGL006W (SEQ ID NO:99, SEQ ID NO:100), YGL114W (SEQ ID NO:101, SEQ ID NO:102), YGR125W (SEQ ID NO:103, SEQ ID NO:104), YGR181W (SEQ ID NO:105, SEQ ID NO:106), YIL088C (SEQ ID NO:107, SEQ ID NO:108), YJR124C (SEQ ID NO:109, SEQ ID NO:110), YPL134C (SEQ ID NO:111, SEQ ID NO:112), YPR192W (SEQ ID NO:113, SEQ ID NO:114), YPR194C (SEQ ID NO:115, SEQ ID NO:116), YPR198W (SEQ ID NO:117, SEQ ID NO:118), YPR201W (SEQ ID NO:119, SEQ ID NO:120), YAL067C (SEQ ID NO:121, SEQ ID NO:122), YBL089W (SEQ ID NO:123, SEQ ID NO:124), YCR028C (SEQ ID NO:125, SEQ ID NO:126), YDR438W (SEQ ID NO:127, SEQ ID NO:128), YFL011W (SEQ ID NO:129, SEQ ID NO:130), YGL084C (SEQ ID NO:131, SEQ ID NO:132), YGL104C (SEQ ID NO:133, SEQ ID NO:134), YGR224W (SEQ ID NO:135, SEQ ID NO:136), YHR032W (SEQ ID NO:137, SEQ ID NO:138), YJL093C (SEQ ID NO:53, SEQ ID NO:54), YMR034C (SEQ ID NO:139, SEQ ID NO:140), YNR055C (SEQ ID NO:141, SEQ ID NO:142), YOL020W (SEQ ID NO:143, SEQ ID NO:144), or YOL075C (SEQ ID NO:145, SEQ ID NO:146). In some embodiments, RebA, RebB, RebD, and/or RebM production is increased. See Example 4.
(81) Steviol and Steviol Glycoside Biosynthesis Nucleic Acids
(82) A recombinant gene encoding a polypeptide described herein comprises the coding sequence for that polypeptide, operably linked in sense orientation to one or more regulatory regions suitable for expressing the polypeptide. Because many microorganisms are capable of expressing multiple gene products from a polycistronic mRNA, multiple polypeptides can be expressed under the control of a single regulatory region for those microorganisms, if desired. A coding sequence and a regulatory region are considered to be operably linked when the regulatory region and coding sequence are positioned so that the regulatory region is effective for regulating transcription or translation of the sequence. Typically, the translation initiation site of the translational reading frame of the coding sequence is positioned between one and about fifty nucleotides downstream of the regulatory region for a monocistronic gene.
(83) In many cases, the coding sequence for a polypeptide described herein is identified in a species other than the recombinant host, i.e., is a heterologous nucleic acid. Thus, if the recombinant host is a microorganism, the coding sequence can be from other prokaryotic or eukaryotic microorganisms, from plants or from animals. In some case, however, the coding sequence is a sequence that is native to the host and is being reintroduced into that organism. A native sequence can often be distinguished from the naturally occurring sequence by the presence of non-natural sequences linked to the exogenous nucleic acid, e.g., non-native regulatory sequences flanking a native sequence in a recombinant nucleic acid construct. In addition, stably transformed exogenous nucleic acids typically are integrated at positions other than the position where the native sequence is found. Regulatory region refers to a nucleic acid having nucleotide sequences that influence transcription or translation initiation and rate, and stability and/or mobility of a transcription or translation product. Regulatory regions include, without limitation, promoter sequences, enhancer sequences, response elements, protein recognition sites, inducible elements, protein binding sequences, 5 and 3 untranslated regions (UTRs), transcriptional start sites, termination sequences, polyadenylation sequences, introns, and combinations thereof. A regulatory region typically comprises at least a core (basal) promoter. A regulatory region also may include at least one control element, such as an enhancer sequence, an upstream element or an upstream activation region (UAR). A regulatory region is operably linked to a coding sequence by positioning the regulatory region and the coding sequence so that the regulatory region is effective for regulating transcription or translation of the sequence. For example, to operably link a coding sequence and a promoter sequence, the translation initiation site of the translational reading frame of the coding sequence is typically positioned between one and about fifty nucleotides downstream of the promoter. A regulatory region can, however, be positioned as much as about 5,000 nucleotides upstream of the translation initiation site, or about 2,000 nucleotides upstream of the transcription start site.
(84) The choice of regulatory regions to be included depends upon several factors, including, but not limited to, efficiency, selectability, inducibility, desired expression level, and preferential expression during certain culture stages. It is a routine matter for one of skill in the art to modulate the expression of a coding sequence by appropriately selecting and positioning regulatory regions relative to the coding sequence. It will be understood that more than one regulatory region may be present, e.g., introns, enhancers, upstream activation regions, transcription terminators, and inducible elements.
(85) One or more genes can be combined in a recombinant nucleic acid construct in modules useful for a discrete aspect of steviol and/or steviol glycoside production. Combining a plurality of genes in a module, particularly a polycistronic module, facilitates the use of the module in a variety of species. For example, a steviol biosynthesis gene cluster, or a UGT gene cluster, can be combined in a polycistronic module such that, after insertion of a suitable regulatory region, the module can be introduced into a wide variety of species. As another example, a UGT gene cluster can be combined such that each UGT coding sequence is operably linked to a separate regulatory region, to form a UGT module. Such a module can be used in those species for which monocistronic expression is necessary or desirable. In addition to genes useful for steviol or steviol glycoside production, a recombinant construct typically also contains an origin of replication, and one or more selectable markers for maintenance of the construct in appropriate species.
(86) It will be appreciated that because of the degeneracy of the genetic code, a number of nucleic acids can encode a particular polypeptide; i.e., for many amino acids, there is more than one nucleotide triplet that serves as the codon for the amino acid. Thus, codons in the coding sequence for a given polypeptide can be modified such that optimal expression in a particular host is obtained, using appropriate codon bias tables for that host (e.g., microorganism). As isolated nucleic acids, these modified sequences can exist as purified molecules and can be incorporated into a vector or a virus for use in constructing modules for recombinant nucleic acid constructs.
(87) In some cases, it is desirable to inhibit one or more functions of an endogenous polypeptide in order to divert metabolic intermediates towards steviol or steviol glycoside biosynthesis. For example, it may be desirable to downregulate synthesis of sterols in a yeast strain in order to further increase steviol or steviol glycoside production, e.g., by downregulating squalene epoxidase. As another example, it may be desirable to inhibit degradative functions of certain endogenous gene products, e.g., glycohydrolases that remove glucose moieties from secondary metabolites or phosphatases as discussed herein. As another example, expression of membrane transporters involved in transport of steviol glycosides can be activated, such that transportation of glycosylated steviosides is increased. Such regulation can be beneficial in that transportation of steviol glycosides can be increased for a desired period of time during culture of the microorganism, thereby increasing the yield of glycoside product(s) at harvest. In such cases, a nucleic acid that overexpresses the polypeptide or gene product may be included in a recombinant construct that is transformed into the strain. Alternatively, mutagenesis can be used to generate mutants in genes for which it is desired to increase or enhance function.
(88) Host Microorganisms
(89) Recombinant hosts can be used to express polypeptides for the producing steviol glycosides, including mammalian, insect, plant, and algal cells. A number of prokaryotes and eukaryotes are also suitable for use in constructing the recombinant microorganisms described herein, e.g., gram-negative bacteria, yeast, and fungi. A species and strain selected for use as a steviol glycoside production strain is first analyzed to determine which production genes are endogenous to the strain and which genes are not present. Genes for which an endogenous counterpart is not present in the strain are advantageously assembled in one or more recombinant constructs, which are then transformed into the strain in order to supply the missing function(s).
(90) Typically, the recombinant microorganism is grown in a fermenter at a defined temperature(s) for a desired period of time. The constructed and genetically engineered microorganisms provided by the invention can be cultivated using conventional fermentation processes, including, inter alia, chemostat, batch, fed-batch cultivations, semi-continuous fermentations such as draw and fill, continuous perfusion fermentation, and continuous perfusion cell culture. Depending on the particular microorganism used in the method, other recombinant genes such as isopentenyl biosynthesis genes and terpene synthase and cyclase genes may also be present and expressed. Levels of substrates and intermediates, e.g., isopentenyl diphosphate, dimethylallyl diphosphate, GGPP, kaurene and kaurenoic acid, can be determined by extracting samples from culture media for analysis according to published methods.
(91) Carbon sources of use in the instant method include any molecule that can be metabolized by the recombinant host cell to facilitate growth and/or production of the steviol glycosides. Examples of suitable carbon sources include, but are not limited to, sucrose (e.g., as found in molasses), fructose, xylose, ethanol, glycerol, glucose, cellulose, starch, cellobiose or other glucose-comprising polymer. In embodiments employing yeast as a host, for example, carbons sources such as sucrose, fructose, xylose, ethanol, glycerol, and glucose are suitable. The carbon source can be provided to the host organism throughout the cultivation period or alternatively, the organism can be grown for a period of time in the presence of another energy source, e.g., protein, and then provided with a source of carbon only during the fed-batch phase.
(92) After the recombinant microorganism has been grown in culture for the desired period of time, steviol and/or one or more steviol glycosides can then be recovered from the culture using various techniques known in the art. In some embodiments, a permeabilizing agent can be added to aid the feedstock entering into the host and product getting out. For example, a crude lysate of the cultured microorganism can be centrifuged to obtain a supernatant. The resulting supernatant can then be applied to a chromatography column, e.g., a C-18 column, and washed with water to remove hydrophilic compounds, followed by elution of the compound(s) of interest with a solvent such as methanol. The compound(s) can then be further purified by preparative HPLC. See also, WO 2009/140394.
(93) It will be appreciated that the various genes and modules discussed herein can be present in two or more recombinant hosts rather than a single host. When a plurality of recombinant hosts is used, they can be grown in a mixed culture to produce steviol and/or steviol glycosides.
(94) Alternatively, the two or more hosts each can be grown in a separate culture medium and the product of the first culture medium, e.g., steviol, can be introduced into second culture medium to be converted into a subsequent intermediate, or into an end product such as, for example, RebA. The product produced by the second, or final host is then recovered. It will also be appreciated that in some embodiments, a recombinant host is grown using nutrient sources other than a culture medium and utilizing a system other than a fermenter.
(95) Exemplary prokaryotic and eukaryotic species are described in more detail below. However, it will be appreciated that other species can be suitable. For example, suitable species can be in a genus such as Agaricus, Aspergillus, Bacillus, Candida, Corynebacterium, Eremothecium, Escherichia, Fusarium/Gibberella, Kluyveromyces, Laetiporus, Lentinus, Phaffia, Phanerochaete, Pichia, Physcomitrella, Rhodoturula, Saccharomyces, Schizosaccharomyces, Sphaceloma, Xanthophyllomyces or Yarrowia. Exemplary species from such genera include Lentinus tigrinus, Laetiporus sulphureus, Phanerochaete chrysosporium, Pichia pastoris, Cyberlindnera jadinii, Physcomitrella patens, Rhodoturula glutinis, Rhodoturula mucilaginosa, Phaffia rhodozyma, Xanthophyllomyces dendrorhous, Fusarium fujikuroi/Gibberella fujikuroi, Candida utilis, Candida glabrata, Candida albicans, and Yarrowia lipolytica.
(96) In some embodiments, a microorganism can be a prokaryote such as Escherichia coli.
(97) In some embodiments, a microorganism can be an Ascomycete such as Gibberella fujikuroi, Kluyveromyces lactis, Schizosaccharomyces pombe, Aspergillus niger, Yarrowia lipolytica, Ashbya gossypii, or S. cerevisiae.
(98) In some embodiments, a microorganism can be an algal cell such as Blakeslea trispora, Dunaliella salina, Haematococcus pluvialis, Chlorella sp., Undaria pinnatifida, Sargassum, Laminaria japonica, Scenedesmus almeriensis species.
(99) In some embodiments, a microorganism can be a cyanobacterial cell such as Blakeslea trispora, Dunaliella salina, Haematococcus pluvialis, Chlorella sp., Undaria pinnatifida, Sargassum, Laminaria japonica, Scenedesmus almeriensis.
(100) Saccharomyces spp.
(101) Saccharomyces is a widely used chassis organism in synthetic biology, and can be used as the recombinant microorganism platform. For example, there are libraries of mutants, plasmids, detailed computer models of metabolism and other information available for S. cerevisiae, allowing for rational design of various modules to enhance product yield. Methods are known for making recombinant microorganisms.
(102) Aspergillus spp.
(103) Aspergillus species such as A. oryzae, A. niger and A. sojae are widely used microorganisms in food production and can also be used as the recombinant microorganism platform. Nucleotide sequences are available for genomes of A. nidulans, A. fumigatus, A. oryzae, A. clavatus, A. flavus, A. niger, and A. terreus, allowing rational design and modification of endogenous pathways to enhance flux and increase product yield. Metabolic models have been developed for Aspergillus, as well as transcriptomic studies and proteomics studies. A. niger is cultured for the industrial production of a number of food ingredients such as citric acid and gluconic acid, and thus species such as A. niger are generally suitable for producing steviol glycosides.
(104) E. coli
(105) E. coli, another widely used platform organism in synthetic biology, can also be used as the recombinant microorganism platform. Similar to Saccharomyces, there are libraries of mutants, plasmids, detailed computer models of metabolism and other information available for E. coli, allowing for rational design of various modules to enhance product yield. Methods similar to those described above for Saccharomyces can be used to make recombinant E. coli microorganisms.
(106) Agaricus, Gibberella, and Phanerochaete spp.
(107) Agaricus, Gibberella, and Phanerochaete spp. can be useful because they are known to produce large amounts of isoprenoids in culture. Thus, the terpene precursors for producing large amounts of steviol glycosides are already produced by endogenous genes. Thus, modules comprising recombinant genes for steviol glycoside biosynthesis polypeptides can be introduced into species from such genera without the necessity of introducing mevalonate or MEP pathway genes.
(108) Arxula adeninivorans (Blastobotrys adeninivorans)
(109) Arxula adeninivorans is dimorphic yeast (it grows as budding yeast like the baker's yeast up to a temperature of 42 C., above this threshold it grows in a filamentous form) with unusual biochemical characteristics. It can grow on a wide range of substrates and can assimilate nitrate. It has successfully been applied to the generation of strains that can produce natural plastics or the development of a biosensor for estrogens in environmental samples.
(110) Yarrowia lipolytica
(111) Yarrowia lipolytica is dimorphic yeast (see Arxula adeninivorans) and belongs to the family Hemiascomycetes. The entire genome of Yarrowia lipolytica is known. Yarrowia species is aerobic and considered to be non-pathogenic. Yarrowia is efficient in using hydrophobic substrates (e.g. alkanes, fatty acids, oils) and can grow on sugars. It has a high potential for industrial applications and is an oleaginous microorgamism. Yarrowia lipolyptica can accumulate lipid content to approximately 40% of its dry cell weight and is a model organism for lipid accumulation and remobilization. See e.g., Nicaud, 2012, Yeast 29(10):409-18; Beopoulos et al., 2009, Biochimie 91(6):692-6; Bankar et al., 2009, Appl Microbiol Biotechnol. 84(5):847-65.
(112) Rhodotorula sp.
(113) Rhodotorula is unicellular, pigmented yeast. The oleaginous red yeast, Rhodotorula glutinis, has been shown to produce lipids and carotenoids from crude glycerol (Saenge et al., 2011, Process Biochemistry 46(1):210-8). Rhodotorula toruloides strains have been shown to be an efficient fed-batch fermentation system for improved biomass and lipid productivity (Li et al., 2007, Enzyme and Microbial Technology 41:312-7).
(114) Rhodosporidium toruloides
(115) Rhodosporidium toruloides is oleaginous yeast and useful for engineering lipid-production pathways (See e.g. Zhu et al., 2013, Nature Commun. 3:1112; Ageitos et al., 2011, Applied Microbiology and Biotechnology 90(4): 1219-27).
(116) Candida boidinii
(117) Candida boidinii is methylotrophic yeast (it can grow on methanol). Like other methylotrophic species such as Hansenula polymorpha and Pichia pastoris, it provides an excellent platform for producing heterologous proteins. Yields in a multigram range of a secreted foreign protein have been reported. A computational method, IPRO, recently predicted mutations that experimentally switched the cofactor specificity of Candida boidinii xylose reductase from NADPH to NADH. See, e.g., Mattanovich et al., 2012, Methods Mol Biol. 824:329-58; Khoury et al., 2009, Protein Sci. 18(10):2125-38.
(118) Hansenula polymorpha (Pichia angusta)
(119) Hansenula polymorpha is methylotrophic yeast (see Candida boidinii). It can furthermore grow on a wide range of other substrates; it is thermo-tolerant and can assimilate nitrate (see also Kluyveromyces lactis). It has been applied to producing hepatitis B vaccines, insulin and interferon alpha-2a for the treatment of hepatitis C, furthermore to a range of technical enzymes. See, e.g., Xu et al., 2014, Virol Sin. 29(6):403-9.
(120) Kluyveromyces lactis
(121) Kluyveromyces lactis is yeast regularly applied to the production of kefir. It can grow on several sugars, most importantly on lactose which is present in milk and whey. It has successfully been applied among others for producing chymosin (an enzyme that is usually present in the stomach of calves) for producing cheese. Production takes place in fermenters on a 40,000 L scale. See, e.g., van Ooyen et al., 2006, FEMS Yeast Res. 6(3):381-92.
(122) Pichia pastoris
(123) Pichia pastoris is methylotrophic yeast (see Candida boidinii and Hansenula polymorpha). It provides an efficient platform for producing foreign proteins. Platform elements are available as a kit and it is worldwide used in academia for producing proteins. Strains have been engineered that can produce complex human N-glycan (yeast glycans are similar but not identical to those found in humans). See, e.g., Piirainen et al., 2014, N Biotechnol. 31(6):532-7.
(124) Physcomitrella spp.
(125) Physcomitrella mosses, when grown in suspension culture, have characteristics similar to yeast or other fungal cultures. This genera can be used for producing plant secondary metabolites, which can be difficult to produce in other types of cells.
(126) Steviol Glycoside Compositions
(127) Steviol glycosides do not necessarily have equivalent performance in different food systems. It is therefore desirable to have the ability to direct the synthesis to steviol glycoside compositions of choice. Recombinant hosts described herein can produce compositions that are selectively enriched for specific steviol glycosides (e.g., RebD or RebM) and have a consistent taste profile. Thus, the recombinant hosts described herein can facilitate the production of compositions that are tailored to meet the sweetening profile desired for a given food product and that have a proportion of each steviol glycoside that is consistent from batch to batch. Hosts described herein do not produce the undesired plant by-products found in Stevia extracts. Thus, steviol glycoside compositions produced by the recombinant hosts described herein are distinguishable from compositions derived from Stevia plants.
(128) The amount of an individual steviol glycoside (e.g., RebA, RebB, RebD, or RebM) produced can be from about 1 mg/L to about 7,000 mg/L, e.g., about 1 to about 10 mg/L, about 3 to about 10 mg/L, about 5 to about 20 mg/L, about 10 to about 50 mg/L, about 10 to about 100 mg/L, about 25 to about 500 mg/L, about 100 to about 1,500 mg/L, or about 200 to about 1,000 mg/L, at least about 1,000 mg/L, at least about 1,200 mg/L, at least about at least 1,400 mg/L, at least about 1,600 mg/L, at least about 1,800 mg/L, at least about 2,800 mg/L, or at least about 7,000 mg/L. In some aspects, the amount of an individual steviol glycoside can exceed 7,000 mg/L. The amount of a combination of steviol glycosides (e.g., RebA, RebB, RebD, or RebM) produced can be from about 1 mg/L to about 7,000 mg/L, e.g., about 200 to about 1,500, at least about 2,000 mg/L, at least about 3,000 mg/L, at least about 4,000 mg/L, at least about 5,000 mg/L, at least about 6,000 mg/L, or at least about 7,000 mg/L. In some aspects, the amount of a combination of steviol glycosides can exceed 7,000 mg/L. In general, longer culture times will lead to greater amounts of product. Thus, the recombinant microorganism can be cultured for from 1 day to 7 days, from 1 day to 5 days, from 3 days to 5 days, about 3 days, about 4 days, or about 5 days.
(129) It will be appreciated that the various genes and modules discussed herein can be present in two or more recombinant microorganisms rather than a single microorganism. When a plurality of recombinant microorganisms is used, they can be grown in a mixed culture to produce steviol and/or steviol glycosides. For example, a first microorganism can comprise one or more biosynthesis genes for producing steviol and null mutations in a first group of endogenous transporters, while a second microorganism comprises steviol glycoside biosynthesis genes and null mutations in a second group of endogenous transporters. The product produced by the second, or final microorganism is then recovered. It will also be appreciated that in some embodiments, a recombinant microorganism is grown using nutrient sources other than a culture medium and utilizing a system other than a fermenter.
(130) Alternatively, the two or more microorganisms each can be grown in a separate culture medium and the product of the first culture medium, e.g., steviol, can be introduced into second culture medium to be converted into a subsequent intermediate, or into an end product such as RebA. The product produced by the second, or final microorganism is then recovered. The microorganisms can have the same or a different group of mutations in endogenous transporters. It will also be appreciated that in some embodiments, a recombinant microorganism is grown using nutrient sources other than a culture medium and utilizing a system other than a fermenter.
(131) Steviol glycosides do not necessarily have equivalent performance in different food systems. It is therefore desirable to have the ability to direct the synthesis to steviol glycoside compositions of choice. Recombinant hosts described herein can produce compositions that are selectively enriched for specific steviol glycosides (e.g., RebD) and have a consistent taste profile. Thus, the recombinant microorganisms described herein can facilitate the production of compositions that are tailored to meet the sweetening profile desired for a given food product and that have a proportion of each steviol glycoside that is consistent from batch to batch. Microorganisms described herein do not produce the undesired plant byproducts found in Stevia extracts. Thus, steviol glycoside compositions produced by the recombinant microorganisms described herein are distinguishable from compositions derived from Stevia plants.
(132) Steviol glycosides and compositions obtained by the methods disclosed herein can be used to make food products, dietary supplements and sweetener compositions. See, e.g., WO 2011/153378, WO 2013/022989, WO 2014/122227, and WO 2014/122328, each of which has been incorporated by reference in its entirety.
(133) For example, substantially pure steviol or steviol glycoside such as RebM or RebD can be included in food products such as ice cream, carbonated beverages, fruit juices, yogurts, baked goods, chewing gums, hard and soft candies, and sauces. Substantially pure steviol or steviol glycoside can also be included in non-food products such as pharmaceutical products, medicinal products, dietary supplements and nutritional supplements. Substantially pure steviol or steviol glycosides may also be included in animal feed products for both the agriculture industry and the companion animal industry. Alternatively, a mixture of steviol and/or steviol glycosides can be made by culturing recombinant microorganisms separately, each producing a specific steviol or steviol glycoside, recovering the steviol or steviol glycoside in substantially pure form from each microorganism and then combining the compounds to obtain a mixture comprising each compound in the desired proportion. The recombinant microorganisms described herein permit more precise and consistent mixtures to be obtained compared to current Stevia products. For example, recombinant microorganisms described herein can express transporters specific for transport of a particular steviol glycoside into the culture medium. When a transporter is specific for a particular steviol glycoside it will enrich the concentration of that compound in the fermentation broth, preventing it from being further reacted to a different compound, and by selectively transporting the steviol glycoside into the fermentation broth it will make it easier to recover from the other steviol glycosides and therefore making the process more efficient.
(134) In another alternative, a substantially pure steviol or steviol glycoside can be incorporated into a food product along with other sweeteners, e.g. saccharin, dextrose, sucrose, fructose, erythritol, aspartame, sucralose, monatin, or acesulfame potassium. The weight ratio of steviol or steviol glycoside relative to other sweeteners can be varied as desired to achieve a satisfactory taste in the final food product. See, e.g., U.S. 2007/0128311. In some embodiments, the steviol or steviol glycoside may be provided with a flavor (e.g., citrus) as a flavor modulator.
(135) Compositions produced by a recombinant microorganism described herein can be incorporated into food products. For example, a steviol glycoside composition produced by a recombinant microorganism can be incorporated into a food product in an amount ranging from about 20 mg steviol glycoside/kg food product to about 1800 mg steviol glycoside/kg food product on a dry weight basis, depending on the type of steviol glycoside and food product. For example, a steviol glycoside composition produced by a recombinant microorganism can be incorporated into a dessert, cold confectionary (e.g., ice cream), dairy product (e.g., yogurt), or beverage (e.g., a carbonated beverage) such that the food product has a maximum of 500 mg steviol glycoside/kg food on a dry weight basis. A steviol glycoside composition produced by a recombinant microorganism can be incorporated into a baked good (e.g., a biscuit) such that the food product has a maximum of 300 mg steviol glycoside/kg food on a dry weight basis. A steviol glycoside composition produced by a recombinant microorganism can be incorporated into a sauce (e.g., chocolate syrup) or vegetable product (e.g., pickles) such that the food product has a maximum of 1000 mg steviol glycoside/kg food on a dry weight basis. A steviol glycoside composition produced by a recombinant microorganism can be incorporated into a bread such that the food product has a maximum of 160 mg steviol glycoside/kg food on a dry weight basis. A steviol glycoside composition produced by a recombinant microorganism, plant, or plant cell can be incorporated into a hard or soft candy such that the food product has a maximum of 1600 mg steviol glycoside/kg food on a dry weight basis. A steviol glycoside composition produced by a recombinant microorganism, plant, or plant cell can be incorporated into a processed fruit product (e.g., fruit juices, fruit filling, jams, and jellies) such that the food product has a maximum of 1000 mg steviol glycoside/kg food on a dry weight basis.
(136) For example, such a steviol glycoside composition can have from 90-99% RebA and an undetectable amount of stevia plant-derived components, and be incorporated into a food product at from 25-1600 mg/kg, e.g., 100-500 mg/kg, 25-100 mg/kg, 250-1000 mg/kg, 50-500 mg/kg or 500-1000 mg/kg on a dry weight basis.
(137) Such a steviol glycoside composition can be a RebB-enriched composition having greater than 3% RebB and be incorporated into the food product such that the amount of RebB in the product is from 25-1600 mg/kg, e.g., 100-500 mg/kg, 25-100 mg/kg, 250-1000 mg/kg, 50-500 mg/kg or 500-1000 mg/kg on a dry weight basis. Typically, the RebB-enriched composition has an undetectable amount of stevia plant-derived components.
(138) Such a steviol glycoside composition can be a RebD-enriched composition having greater than 3% RebD and be incorporated into the food product such that the amount of RebD in the product is from 25-1600 mg/kg, e.g., 100-500 mg/kg, 25-100 mg/kg, 250-1000 mg/kg, 50-500 mg/kg or 500-1000 mg/kg on a dry weight basis. Typically, the RebD-enriched composition has an undetectable amount of stevia plant-derived components.
(139) Such a steviol glycoside composition can be a RebE-enriched composition having greater than 3% RebE and be incorporated into the food product such that the amount of RebE in the product is from 25-1600 mg/kg, e.g., 100-500 mg/kg, 25-100 mg/kg, 250-1000 mg/kg, 50-500 mg/kg or 500-1000 mg/kg on a dry weight basis. Typically, the RebE-enriched composition has an undetectable amount of stevia plant-derived components.
(140) Such a steviol glycoside composition can be a RebM-enriched composition having greater than 3% RebM and be incorporated into the food product such that the amount of RebM in the product is from 25-1600 mg/kg, e.g., 100-500 mg/kg, 25-100 mg/kg, 250-1000 mg/kg, 50-500 mg/kg or 500-1000 mg/kg on a dry weight basis. Typically, the RebM-enriched composition has an undetectable amount of stevia plant-derived components.
(141) In some embodiments, a substantially pure steviol or steviol glycoside is incorporated into a tabletop sweetener or cup-for-cup product. Such products typically are diluted to the appropriate sweetness level with one or more bulking agents, e.g., maltodextrins, known to those skilled in the art. Steviol glycoside compositions enriched for RebA, RebB, RebD, RebE, or RebM, can be package in a sachet, for example, at from 10,000 to 30,000 mg steviol glycoside/kg product on a dry weight basis, for tabletop use.
(142) The invention will be further described in the following examples, which do not limit the scope of the invention described in the claims.
EXAMPLES
(143) The Examples that follow are illustrative of specific embodiments of the invention, and various uses thereof. They are set forth for explanatory purposes only, and are not to be taken as limiting the invention.
Example 1. Identification of 13-SMG Transporter Candidates
(144) Mechanisms of 13-SMG excretion from a RebD/RebM-producing strain were determined by analyzing 13-SMG levels in both the supernatant and in a complete (total) extract of transporter knockout S. cerevisiae strains. A RebD/RebM-producing strain comprised a recombinant gene encoding a Synechococcus sp. GGPPS7 polypeptide (SEQ ID NO:181, SEQ ID NO:182), a recombinant gene encoding a truncated Zea mays CDPS polypeptide (SEQ ID NO:183, SEQ ID NO:184), a recombinant gene encoding an A. thaliana KS5 polypeptide (SEQ ID NO:185, SEQ ID NO:186), a recombinant gene encoding a recombinant S. rebaudiana KO1 polypeptide (SEQ ID NO:187, SEQ ID NO:188), a recombinant gene encoding an A. thaliana ATR2 polypeptide (SEQ ID NO:189, SEQ ID NO:190), a recombinant gene encoding an SrKAHe1 polypeptide (SEQ ID NO:191, SEQ ID NO:192), a recombinant gene encoding an S. rebaudiana CPR8 polypeptide (SEQ ID NO:193, SEQ ID NO:194), a recombinant gene encoding an S. rebaudiana UGT85C2 polypeptide (SEQ ID NO:195, SEQ ID NO:196), a recombinant gene encoding an S. rebaudiana UGT74G1 polypeptide (SEQ ID NO:197, SEQ ID NO:198), a recombinant gene encoding an S. rebaudiana UGT76G1 polypeptide (SEQ ID NO:199, SEQ ID NO:200), a recombinant gene encoding an S. rebaudiana UGT91D2e-b polypeptide (SEQ ID NO:201, SEQ ID NO:202), and a recombinant gene encoding an O. sativa EUGT11 (SEQ ID NO:203, SEQ ID NO:204) polypeptide was used.
(145) Transporter RNA levels of the RebD/M-producing strain were measured throughout a fermentation cycle by RNA-seq (Illumina HiSeq) and normalized to RNA levels of a control stain, which did not produce steviol glycosides, measured under similar conditions to identify 13-SMG transporter candidates based on the expression profiles of transporter genes. See, e.g., Wang et al., 2010, Nat Rev Genet. 19(1):57-63; Nagalakshmi et al., 2008, Science 320(5881):1344-9; Garber et al., 2011, Nat Methods 8(6):469-77; and Robinson & Oshlack et al., 2010, Genome Biol. 11(3):R25, each of which is incorporated by reference herein in its entirety. RNA preparation was performed as described in Wilhelm et al., 2010, Nature Protocols 5:255-66, which is incorporated by reference herein in its entirety.
(146) Transporter genes were individually knocked out in the RebD/M-producing strain based upon the RNA-seq results described below, and total and supernatant levels of 13-SMG were measured by LC-MS in each transporter knockout strain and a RebD/M-producing background strain, which did not have any transporter genes deleted. Relative excretion was calculated as the 13-SMG supernatant/total ratio of each transporter knockout strain divided by the 13-SMG supernatant/total ratio of the RebD/M-producing control strain. A relative excretion value of less than 1 corresponds to a decrease in 13-SMG excretion by a transporter knockout strain, compared to 13-SMG excretion by a RebD/M-producing control strain (i.e., less than 100% 13-SMG excretion of the control strain). A relative excretion value of 1 corresponds to 13-SMG excretion by a transporter knockout strain equal to that by a RebD/M-producing control strain (i.e., 100% 13-SMG excretion of the control strain). A relative excretion value of greater than 1 corresponds to an increase in 13-SMG excretion by a transporter knockout strain, compared to 13-SMG excretion by a RebD/M-producing control strain (i.e., greater than 100% 13-SMG excretion of the control strain).
(147) LC-MS analyses were performed using an Ultimate 3000 UPLC system (Dionex) fitted with a waters acquity UPLC BEH shield RP18 column (2.150 mm, 1.7 m particles, 130 pore size) connected to a TSQ Quantum Access (ThermoFisher Scientific) triple quadropole mass spectrometer with a heated electrospray ion (HESI) source, unless otherwise indicated. Elution was carried out using a mobile phase of eluent B (MeCN with 0.1% Formic acid) and eluent A (water with 0.1% Formic acid) by increasing the gradient from 25% to 47% B from 0.0 to 4.0 min, increasing 47% to 100% B from 4.0 to 5.0 min, holding 100% B from 5.0 to 6.5 min re-equilibration. The flow rate was 0.4 mL/min, and the column temperature 35 C. The steviol glycosides were detected using SIM (Single Ion Monitoring) with m/z-traces shown in Table 1. The levels of steviol glycosides were quantified by comparing with calibration curves obtained with authentic standards from LGC Standards.
(148) TABLE-US-00001 TABLE 1 LC-MS analytical information for Steviol Glycosides. compound (typical t.sub.R in Description Exact Mass m/z trace min) Steviol + 1 [M + H].sup.+ 481.2 0.5 19-SMG (2.29), 13-SMG 481.2796 503.1 0.5 (3.5) Glucose [M + Na].sup.+ 503.2615 Steviol + 2 [M + Na].sup.+ 665 0.5 rubusoside (2.52) Glucose 665.3149 Steviol-1,2-bioside (2.92) Steviol-1,3-bioside (2.28) Steviol + 3 [M + Na].sup.+ 827.4 0.5 1,2-stevioside (2.01) Glucose 827.3677 1,3-stevioside (2.39) RebB (2.88) Steviol + 4 [M + Na].sup.+ 989.4 0.5 RebA (2.0) Glucose 989.4200 Steviol + 5 [M + Na].sup.+ 1151.4 0.5 RebD (1.1) Glucose 1151.4728 Steviol + 6 [M + Na].sup.+ 1313.5 0.5 RebM (1.3) Glucose 1313.5257
(149) Specificity for 13-SMG, as described herein, was assessed according to measured 13-SMG supernatant/total level ratios and efficacy of overexpression. To classify potential 13-SMG transporter candidates, calculated relative 13-SMG supernatant/total ratios were plotted against relative expression levels for each transporter. Three classes of transporters were identified. The first class of transporters (YOR087W, YML038C, YJR135W-A, YDR406W) demonstrated a higher specificity for 13-SMG compared to a steviol glycoside-producing control strain, but the transporters of the first class were not overexpressed compared to a control strain that did not produce steviol glycosides. The second class of transporters (YIR028W, YGR138C, YJL214W, and YDR345C) demonstrated low 13-SMG specificity compared to a steviol glycoside-producing control strain but high expression levels compared to a control strain that did not produce steviol glycosides. The third class of transporters tested demonstrated a low 13-SMG specificity compared to a steviol glycoside-producing control strain and were not overexpressed compared to a control strain that did not produce steviol glycosides. The transporters of the first and second classes were believed to be capable of excreting more 13-SMG than the transporters of the third class.
(150) Table 2 shows expression levels and relative 13-SMG excretion of YOR087W, YML038C, YJR135W-A, YDR406W, YIR028W, YGR138C, YJL214W, and YDR345C. For example, at the 19 h time point of fermentation, the expression level of YOR087W (SEQ ID NO:1, SEQ ID NO:2) in a RebD/M-producing strain is 86.93% that of the expression level of YOR087W in a control strain. Upon deletion of YOR087W in a RebD/M-producing strain, the 13-SMG supernatant/total ratio was 31% that of the 13-SMG supernatant/total ratio of a RebD/M-producing control strain. In another example, at the 19 h time point of fermentation, the expression level of YDR345C (SEQ ID NO:15, SEQ ID NO:16) was 1,512.89% that of the expression level of YDR345C in a control strain. Upon deletion of YDR345C in a RebD/M-producing strain, the 13-SMG supernatant/total ratio was 75.10% that of the 13-SMG supernatant/total ratio of a RebD/M-producing control strain.
(151) TABLE-US-00002 TABLE 2 13-SMG transporter candidate expression and specificity. Relative Excretion (Transporter Knockout Strain Compared to Relative Expression Level RebD/M-Producing (RebD/M-Producing Strain Transporter Control Strain) Compared to Control Strain) Name ORF Supernatant/Total Ratio 19 h 43 h 50 h 72 h 95 h YVC1 YOR087W 0.31 0.87 0.78 0.83 0.89 0.97 (SEQ ID NO: 1, SEQ ID NO: 2) YMD8 YML038C 0.41 0.95 0.89 0.99 0.86 1.00 (SEQ ID NO: 3, SEQ ID NO: 4) TIM8 YJR135W-A 0.44 1.98 1.22 1.68 2.00 3.30 (SEQ ID NO: 5, SEQ ID NO: 6) PDR15 YDR406W 0.59 2.65 4.94 8.24 7.03 6.89 (SEQ ID NO: 7, SEQ ID NO: 8) DAL4 YIR028W 0.67 11.12 15.86 12.97 13.94 9.92 (SEQ ID NO: 9, SEQ ID NO: 10) TPO2 YGR138C 0.68 2.05 0.67 20.18 15.81 32.45 (SEQ ID NO: 11, SEQ ID NO: 12) HXT8 YJL214W 0.69 18.90 11.64 23.55 17.37 38.28 (SEQ ID NO: 13, SEQ ID NO: 14) HXT3 YDR345C 0.75 15.13 8.63 13.60 6.69 3.42 (SEQ ID NO: 15, SEQ ID NO: 16)
Example 2. Heterologous Expression of RebD and RebM Transporters
(152) A RebD/M-producing strain disclosed in Example 1 was individually transformed using a standard LiAc method (see, e.g., Kawai et al., 2010, Bioeng Bugs. 1(6):395-403) with expression plasmids carrying transporter genes of the SET (sugar efflux transporter) and SWEET families. Steviol glycoside levels were measured using the LC-MS procedure described in Example 1, and OD.sub.600 was measured using a Perkin Elmer 2104 Multilabel reader.
Example 3. Deletion of Trafficking Adapter Genes
(153) A range of adapter proteins are involved in secondary modification of transporter proteins. Art10 (SEQ ID NO:29, SEQ ID NO:30), Art1 (SEQ ID NO:31, SEQ ID NO:32), Art2 (SEQ ID NO:33, SEQ ID NO:34), Art3 (SEQ ID NO:35, SEQ ID NO:36), Art4 (SEQ ID NO:37, SEQ ID NO:38), Art6 (SEQ ID NO:39, SEQ ID NO:40), Art7 (SEQ ID NO:41, SEQ ID NO:42), Art8 (SEQ ID NO:43, SEQ ID NO:44), Bul1 (SEQ ID NO:45, SEQ ID NO:46), and Bul2 (SEQ ID NO:47, SEQ ID NO:48) were individually deleted in a steviol glycoside-producing strain comprising a recombinant gene encoding a Synechococcus sp. GGPPS7 polypeptide (SEQ ID NO:181, SEQ ID NO:182), a recombinant gene encoding a truncated Zea mays CDPS polypeptide (SEQ ID NO:183, SEQ ID NO:184), a recombinant gene encoding an A. thaliana KS5 polypeptide (SEQ ID NO:185, SEQ ID NO:186), a recombinant gene encoding a recombinant S. rebaudiana KO1 polypeptide (SEQ ID NO:187, SEQ ID NO:188), a recombinant gene encoding a KO polypeptide (SEQ ID NO:205, SEQ ID NO:206), recombinant gene encoding an A. thaliana ATR2 polypeptide (SEQ ID NO:189, SEQ ID NO:190), a recombinant gene encoding an SrKAHe1 polypeptide (SEQ ID NO:191, SEQ ID NO:192), a recombinant gene encoding an S. rebaudiana CPR8 polypeptide (SEQ ID NO:193, SEQ ID NO:194), a recombinant gene encoding an S. rebaudiana UGT85C2 polypeptide (SEQ ID NO:195, SEQ ID NO:196), a recombinant gene encoding an S. rebaudiana UGT74G1 polypeptide (SEQ ID NO:197, SEQ ID NO:198), a recombinant gene encoding an S. rebaudiana UGT76G1 polypeptide (SEQ ID NO:199, SEQ ID NO:200), a recombinant gene encoding an S. rebaudiana UGT91D2e-b polypeptide (SEQ ID NO:201, SEQ ID NO:202), and a recombinant gene encoding an O. sativa EUGT11 (SEQ ID NO:203, SEQ ID NO:204) polypeptide.
(154) Deletion of the adapters was carried out by designing primers for PCR comprising a homology region upstream or downstream of the gene to be deleted and a sequence able to bind to a plasmid containing a selection marker. PCR was carried out on the plasmid comprising the selection marker yielding a hybrid DNA sequence comprising the selection marker flanked by upstream and downstream homology regions of the gene to be replaced by the selection marker. The generated PCR fragment was introduced to the RebD/M-producing strain by standard LiAc method and homologous recombination in yeast carried out to replace the endogenous gene with the selection marker. Selection of clones with the selection marker yielded strains with the gene of interest deleted.
(155) The LC-MS method of Example 1 was used, and OD.sub.600 was measured using a Perkin Elmer 2104 Multilabel reader to calculated steviol glycoside levels as M/OD.sub.600. The supernatant/total ratio of the adapter protein knockout strain was compared to the supernatant/total ratio of a control steviol glycoside-producing strain. Fold-change in steviol glycoside excretion for each transporter knockout strain, as compared to steviol glycoside excretion in a control steviol glycoside-producing strain, was calculated. More specifically, values below 1 correspond to a fold-decrease in steviol glycoside excretion compared to a steviol glycoside-producing control strain, values equal to 1 correspond to no fold-change in steviol glycoside excretion compared to a steviol glycoside-producing control strain, and values greater than 1 correspond to a fold-increase in steviol glycoside excretion compared to a steviol glycoside-producing control strain.
(156) Several transporter deletions improved excretion of 13-SMG, RebA, RebB, RebD, and/or RebM in the steviol glycoside-producing strains. See
Example 4. Deletion of Transporter Genes for Improved Production of Steviol Glycosides
(157) Deletion of a single transporter gene in one or two steviol glycoside-producing S. cerevisiae strains was carried out as described in Example 3. Each of the strains comprised a recombinant gene encoding a Synechococcus sp. GGPPS7 polypeptide (SEQ ID NO:181, SEQ ID NO:182), a recombinant gene encoding a truncated Zea mays CDPS polypeptide (SEQ ID NO:183, SEQ ID NO:184), a recombinant gene encoding an A. thaliana KS5 polypeptide (SEQ ID NO:185, SEQ ID NO:186), a recombinant gene encoding a recombinant S. rebaudiana KO1 polypeptide (SEQ ID NO:187, SEQ ID NO:188), a recombinant gene encoding an A. thaliana ATR2 polypeptide (SEQ ID NO:189, SEQ ID NO:190), a recombinant gene encoding an SrKAHe1 polypeptide (SEQ ID NO:191, SEQ ID NO:192), a recombinant gene encoding an S. rebaudiana CPR8 polypeptide (SEQ ID NO:193, SEQ ID NO:194), a recombinant gene encoding an S. rebaudiana UGT85C2 polypeptide (SEQ ID NO:195, SEQ ID NO:196), a recombinant gene encoding an S. rebaudiana UGT74G1 polypeptide (SEQ ID NO:197, SEQ ID NO:198), a recombinant gene encoding an S. rebaudiana UGT76G1 polypeptide (SEQ ID NO:199, SEQ ID NO:200), a recombinant gene encoding an S. rebaudiana UGT91D2e-b polypeptide (SEQ ID NO:201, SEQ ID NO:202), and a recombinant gene encoding an O. sativa EUGT11 (SEQ ID NO:203, SEQ ID NO:204) polypeptide and differed in the copy number of the genes encoding the GGPPS, truncated CDPS, KS, KO, ATR2, EUGT11, SrKAHe1, CPR8, UGT85C2, UGT74G1, UGT76G1, and EUGT11 polypeptides. Fold-change in steviol glycoside production for each transporter knockout strain, as compared to steviol glycoside production in a control steviol glycoside-producing strain, was calculated. More specifically, values below 1 correspond to a fold-decrease in steviol glycoside production compared to a steviol glycoside-producing control strain, values equal to 1 correspond to no fold-change in steviol glycoside production compared to a steviol glycoside-producing control strain, and values greater than 1 correspond to a fold-increase in steviol glycoside production compared to a steviol glycoside-producing control strain.
(158) Several transporter deletions improved production of RebA, RebB, RebD, and/or RebM in the steviol glycoside-producing strains, as measured by the LC-MS method of Example 1. In a first steviol glycoside-producing strain, increased RebB production resulted upon deletion of YBR068C (SEQ ID NO:63, SEQ ID NO:64) (1.41), YBR220C (SEQ ID NO:65, SEQ ID NO:66) (3.91), YBR235W (SEQ ID NO:67, SEQ ID NO:68) (3.26), YBR293W (SEQ ID NO:69, SEQ ID NO:70) (2.35), YBR298C (SEQ ID NO:71, SEQ ID NO:72) (2.24), YCR011C (SEQ ID NO:73, SEQ ID NO:74) (3.98), YCR023C (SEQ ID NO:75, SEQ ID NO:76) (3.93), YDL100C (SEQ ID NO:77, SEQ ID NO:78) (2.14), YDL119C (SEQ ID NO:79, SEQ ID NO:80) (2.20), YDL138W (SEQ ID NO:81, SEQ ID NO:82) (3.51), YDL199C (SEQ ID NO:83, SEQ ID NO:84) (3.54), YDL210W (SEQ ID NO:85, SEQ ID NO:86) (2.64), YDR061W (SEQ ID NO:89, SEQ ID NO:90) (2.65), YDR135C (SEQ ID NO:91, SEQ ID NO:92) (2.82), YEL006W (SEQ ID NO:95, SEQ ID NO:96) (1.46), YFL028C (SEQ ID NO:97, SEQ ID NO:98) (3.00), YGL006W (SEQ ID NO:99, SEQ ID NO:100) (2.46), YGR125W (SEQ ID NO:103, SEQ ID NO:104) (2.73), YGR181W (SEQ ID NO:105, SEQ ID NO:106) (3.32), YIL088C (SEQ ID NO:107, SEQ ID NO:108) (3.05), YJR124C (SEQ ID NO:109, SEQ ID NO:110) (2.68), YPL134C (SEQ ID NO:111, SEQ ID NO:112) (2.01), YPR192W (SEQ ID NO:113, SEQ ID NO:114) (1.71), YPR194C (SEQ ID NO:115, SEQ ID NO:116) (1.99), YPR198W (SEQ ID NO:117, SEQ ID NO:118) (3.53), or YPR201W (SEQ ID NO:119, SEQ ID NO:120) (3.77), wherein the number in parentheses after each SEQ ID NO represents the fold-increase in RebB measured. Increases in RebD production resulted upon deletion of YBR220C (SEQ ID NO:65, SEQ ID NO:66) (1.50), YCR023C (SEQ ID NO:75, SEQ ID NO:76) (1.52), YDR508C (SEQ ID NO:93, SEQ ID NO:94) (1.53), YGL114W (SEQ ID NO:101, SEQ ID NO:102) (1.47), YPL134C (SEQ ID NO:111, SEQ ID NO:112) (1.61), or YPR201W (SEQ ID NO:119, SEQ ID NO:120) (1.41), wherein the number in parentheses after each SEQ ID NO represents the fold-increase in RebD measured. Increased RebM production resulted upon deletion of YDL138W (SEQ ID NO:81, SEQ ID NO:82) (1.53), YDL245C (SEQ ID NO:87, SEQ ID NO:88) (1.41), or YDR508C (SEQ ID NO:93, SEQ ID NO:94) (1.54), wherein the number in parentheses after each SEQ ID NO represents the fold-increase in RebM measured.
(159) In a second steviol glycoside-producing strain, which comprised a higher copy number of genes encoding GGPPS, truncated CDPS, KS, KO, ATR2, EUGT11, SrKAHe1, CPR8, UGT85C2, UGT74G1, UGT76G1, and EUGT11 polypeptides, increased RebA production resulted upon deletion of YBR235W (SEQ ID NO:67, SEQ ID NO:68) (1.66), YCR023C (SEQ ID NO:75, SEQ ID NO:76) (1.75), YDL100C (SEQ ID NO:77, SEQ ID NO:78) (1.67), YDL138W (SEQ ID NO:81, SEQ ID NO:82) (1.58), YDR438W (SEQ ID NO:127, SEQ ID NO:128) (1.51), YGL084C (SEQ ID NO:131, SEQ ID NO:132) (1.72), YGL114W (SEQ ID NO:101, SEQ ID NO:102) (1.93), YGR224W (SEQ ID NO:135, SEQ ID NO:136) (1.56), or YJL093C (SEQ ID NO:53, SEQ ID NO:54) (1.49), wherein the number in parentheses after each SEQ ID NO represents the fold-increase in RebA measured. Increased RebB production resulted upon deletion of YBR235W (SEQ ID NO:67. SEQ ID NO:68) (1.47), YCR023C (SEQ ID NO:75, SEQ ID NO:76) (1.43), YDL100C (SEQ ID NO:77, SEQ ID NO:78) (1.50), YDL138W (SEQ ID NO:81, SEQ ID NO:82) (1.49), YGL084C (SEQ ID NO:131, SEQ ID NO:132) (1.61), YGL114W (SEQ ID NO:101, SEQ ID NO:102) (1.70), wherein the number in parentheses after each SEQ ID NO represents the fold-increase in RebB measured. Increased RebD production resulted upon deletion of YAL067C (SEQ ID NO:121, SEQ ID NO:122) (1.66), YBL089W (SEQ ID NO:123, SEQ ID NO:124) (1.58), YBR220C (SEQ ID NO:65, SEQ ID NO:66) (1.77), YBR235W (SEQ ID NO:67, SEQ ID NO:68) (2.06), YCR011C (SEQ ID NO:73, SEQ ID NO:74) (1.45), YCR023C (SEQ ID NO:75, SEQ ID NO:76) (1.99), YCR028C (SEQ ID NO:125, SEQ ID NO:126) (1.61), YDL100C (SEQ ID NO:77, SEQ ID NO:78) (2.13), YDL138W (SEQ ID NO:81, SEQ ID NO:82) (1.94), YDL199C (SEQ ID NO:83, SEQ ID NO:84) (1.65), YDR438W (SEQ ID NO:127, SEQ ID NO:128) (1.84), YFL011W (SEQ ID NO:129, SEQ ID NO:130) (1.48), YGL006W (SEQ ID NO:99, SEQ ID NO:100) (1.71), YGL084C (SEQ ID NO:131, SEQ ID NO:132) (2.17), YGL104C (SEQ ID NO:133, SEQ ID NO:134) (1.78), YGL114W (SEQ ID NO:101, SEQ ID NO:102) (2.55), YGR125W (SEQ ID NO:103, SEQ ID NO:104) (1.67), YGR224W (SEQ ID NO:135, SEQ ID NO:136) (1.79), YHR032W (SEQ ID NO:137, SEQ ID NO:138) (1.59), YJL093C (SEQ ID NO:53, SEQ ID NO:54) (1.74), YMR034C (SEQ ID NO:139, SEQ ID NO:140) (1.43), YNR055C (SEQ ID NO:141, SEQ ID NO:142) (1.86), YOL020W (SEQ ID NO:143, SEQ ID NO:144) (1.16), or YOL075C (SEQ ID NO:145, SEQ ID NO:146) (1.41), wherein the number in parentheses after each SEQ ID NO represents the fold-increase in RebD measured. Increased production of RebM resulted upon deletion of YBR235W (SEQ ID NO:67, SEQ ID NO:68) (1.73), YCR023C (SEQ ID NO:75, SEQ ID NO:76) (1.55), YCR028C (SEQ ID NO:125, SEQ ID NO:126) (1.69), YDL100C (SEQ ID NO:77, SEQ ID NO:78) (1.88), YDL138W (SEQ ID NO:81, SEQ ID NO:82) (1.67), YDR438W (SEQ ID NO:127, SEQ ID NO:128) (1.56), YGL006W (SEQ ID NO:99, SEQ ID NO:100) (1.58), YGL084C (SEQ ID NO:131, SEQ ID NO:132) (1.56), YGL104C (SEQ ID NO:133, SEQ ID NO:134) (1.62), YGL114W (SEQ ID NO:101, SEQ ID NO:102) (2.29), or YGR224W (SEQ ID NO:135, SEQ ID NO:136) (1.43), wherein the number in parentheses after each SEQ ID NO represents the fold-increase in RebM measured.
(160) TABLE-US-00003 TABLE3 Sequencesdisclosedherein. SEQIDNO:1 atggtatcagccaacggcgacttgcacttgccaatttctaacgaacagtgcatgccggaa 60 aacaatggatctcttggatttgaggcccccactccgagacagattctcagggttacgtta 120 aatttgaaatacttaattgataaggtcgtacctattgtttacgatcccaatgatattgtt 180 tgtgaccattctgagattttatctccaaaagttgtgaagctggcttatgaagcatgtggc 240 gggaaccctaaagacaaggccaacaaaagaaaatatcaatctgtcattattttttcactt 300 cttaaagtttgtgagtggtattccatattggccactatggaagtgcacaatgccaaactt 360 tacgaaaccagaaatttagcctcacaacagttatgtaaattgttaattgaaagggaggag 420 acaagagacctgcagtttcttttcatgcagttactgctgcgtcggtacgtaatcaacgag 480 aacgatgaagatcaagaaccgttgaatgccttggaacttgccacagatatgcactgtact 540 acagtgataggatcgagtggatttcagcgttgtttaaaatggatatggagaggatggata 600 gtccaaaatggcttggatcccacaacttttatcaaggacgattcactggcggaagtgtca 660 ttgatctctcatttcaaccccgtaagattaaaggcgcctgtataccaaaattatttgcag 720 atgatcttctcatttttgtttctagggctttataccttggtggttaatggtaaggactct 780 gagagagtccaatctttcgatttgttagaaagcatattttatgttttcaatactggtttc 840 atcttggatgagctcactaagctttattatattggttatgcgcacctatcgttttggaat 900 ttatttaatgataccacatatttgataatcacgtttgctatggggttccgtgcaatgagc 960 gtaacgccccttaatgcaaaatactcttcagaagattgggataaaatatcatatagagtc 1020 ttatcctgtgcagcaccatttgtgtggtcgagactcctactataccttgaatcacaaagg 1080 tttattgggattatgttggttatcctaaaacatatgatgaaagaatccattgtatttttc 1140 ttccttctattcttaataatgataggattcactcaaggtttcttaggtttggattccgca 1200 gatggtaagagagatatcaccggacccatcctgggtaatttaacaatcaccgttttgggt 1260 cttggtagttttgatgttttcgaagaattcgctcccccatatgcggcaatactgtattat 1320 ggttactattttattgtttcggttatccttttgaatatattaattgctttgtattcgact 1380 gcgtaccaaaaagttattgacaatgcagatgacgagtacatggctttgatgtcacaaaag 1440 acgttgagatacattagagcacctgatgaagatgtctatgtttctccattgaacttaatt 1500 gaagtgttcatgacacctatctttcgtattcttccaccgaagcgtgctaaagatttgagc 1560 tatactgtaatgacaatagtgtacagcccatttttgttgcttatttctgttaaagaaact 1620 cgggaggctagaaggataaaatataacaggatgaaaaggttaaacgatgatgccaatgaa 1680 tatgatactccatgggatttgacagatggctacttggatgatgatgacggtttgttttct 1740 gataaccgaaattctggcatgagagccacccagttaaagaattcccgttcgctaaaactg 1800 caaagaacagcagagcaggaagatgtccattttaaagtccctaagaagtggtataaaaac 1860 gttaaaaaatgcagtccctccttcgaacagtatgataacgatgacactgaagatgatgct 1920 ggtgaagataaagatgaagtcaaagagctcactaagaaagtggaaaacttgacagctgta 1980 attaccgatctactcgaaaaattagacataaaggataagaaagagtaa 2028 SEQIDNO:2 MVSANGDLHLPISNEQCMPENNGSLGFEAPTPRQILRVTLNLKYLIDKVVPIVYDPNDIV 60 CDHSEILSPKVVKLAYEACGGNPKDKANKRKYQSVIIFSLLKVCEWYSILATMEVHNAKL 120 YETRNLASQQLCKLLIEREETRDLQFLFMQLLLRRYVINENDEDQEPLNALELATDMHCT 180 TVIGSSGFQRCLKWIWRGWIVQNGLDPTTFIKDDSLAEVSLISHFNPVRLKAPVYQNYLQ 240 MIFSFLFLGLYTLVVNGKDSERVQSFDLLESIFYVFNTGFILDELTKLYYIGYAHLSFWN 300 LFNDTTYLIITFAMGFRAMSVTPLNAKYSSEDWDKISYRVLSCAAPFVWSRLLLYLESQR 360 FIGIMLVILKHMMKESIVFFFLLFLIMIGFTQGFLGLDSADGKRDITGPILGNLTITVLG 420 LGSFDVFEEFAPPYAAILYYGYYFIVSVILLNILIALYSTAYQKVIDNADDEYMALMSQK 480 TLRYIRAPDEDVYVSPLNLIEVFMTPIFRILPPKRAKDLSYTVMTIVYSPFLLLISVKET 540 REARRIKYNRMKRLNDDANEYDTPWDLTDGYLDDDDGLFSDNRNSGMRATQLKNSRSLKL 600 QRTAEQEDVHFKVPKKWYKNVKKCSPSFEQYDNDDTEDDAGEDKDEVKELTKKVENLTAV 660 ITDLLEKLDIKDKKE 675 SEQIDNO:3 atgaataggactgtctttttggcatttgtatttggatggtatttctgttcaatagctctc 60 tccatatacaatagatggatgttcgatccgaaggacggattgggtattgggtatcccgtg 120 ttggtgacaacattccatcaggctactttatggttactatccggcatatacattaagctc 180 aggcataagccagtgaaaaacgttttaagaaagaataatggttttaactggagttttttt 240 ctaaaatttttactccctacggcagtcgcttctgcaggtgatatcgggctcagtaacgtt 300 tccttccagtatgttcccttgacaatttatacaattatcaaatcttcgagcatagctttt 360 gtccttttattcggctgtatcttcaagctagaaaagtttcattggaagttggcactttca 420 gtaataattatgtttgttggtgtagcattaatggttttcaaaccaagcgattccaccagt 480 accaaaaacgaccaagccttggtcatttttggcagctttcttgtcctagcaagtagctgt 540 ctttctgggttaaggtgggtttatacgcagttgatgcttaggaacaacccaattcaaact 600 aacaccgctgcagcagtagaggaatctgatggtgcccttttcacggaaaatgaagataat 660 gtcgataatgaacctgttgttaacctcgccaataacaaaatgctggagaattttggagaa 720 tccaagcctcacccaattcatacaatccaccagttagctcctataatgggcattactctg 780 ttgcttacctcgctacttgtggaaaaaccatttcctggtatattcagctctagcatattt 840 aggcttgatacgagcaatggcggtgtcggcacggaaactaccgtcctatccattgtgagg 900 ggtattgttttgttaattttacctggttttgcagtctttttgttgacaatttgtgagttt 960 agtattttggagcaaacgcccgtgctgaccgtatctattgtgggtatagtgaaggaactt 1020 ttgacggtaatatttggtataattattctttctgaaagattaagtggtttttacaattgg 1080 ttaggaatgcttattattatggcagatgtatgctattataattacttcagatataagcaa 1140 gatctattacaaaaatatcattcagtttcgacacaagataatcgtaacgagttaaaggga 1200 tttcaagacttcgaacagttaggaagcaagaaaatcgcaccatattctattagtgtcgac 1260 ctaacaaatcaagagtatgagcttgatatgattgctcaaaacgttagtcgttcatcccag 1320 caggtctga 1329 SEQIDNO:4 MNRTVFLAFVFGWYFCSIALSIYNRWMFDPKDGLGIGYPVLVTTFHQATLWLLSGIYIKL 60 RHKPVKNVLRKNNGFNWSFFLKFLLPTAVASAGDIGLSNVSFQYVPLTIYTIIKSSSIAF 120 VLLFGCIFKLEKFHWKLALSVIIMFVGVALMVFKPSDSTSTKNDQALVIFGSFLVLASSC 180 LSGLRWVYTQLMLRNNPIQTNTAAAVEESDGALFTENEDNVDNEPVVNLANNKMLENFGE 240 SKPHPIHTIHQLAPIMGITLLLTSLLVEKPFPGIFSSSIFRLDTSNGGVGTETTVLSIVR 300 GIVLLILPGFAVFLLTICEFSILEQTPVLTVSIVGIVKELLTVIFGIIILSERLSGFYNW 360 LGMLIIMADVCYYNYFRYKQDLLQKYHSVSTQDNRNELKGFQDFEQLGSKKIAPYSISVD 420 LTNQEYELDMIAQNVSRSSQQV 442 SEQIDNO:5 atgtcttctctatcaacgtctgatttggcctcccttgatgacacttccaaaaaggaaatt 60 gctactttcttggagggagagaactccaaacaaaaagtccagatgtcaatccatcaattc 120 actaatatatgcttcaaaaaatgtgttgagtctgtcaatgattctaatttaagttcgcaa 180 gaagagcaatgtttgtctaactgtgtgaatcggtttttggatactaatatcaggattgtg 240 aacgggttgcaaaacacccgttaa 264 SEQIDNO:6 MSSLSTSDLASLDDTSKKEIATFLEGENSKQKVQMSIHQFTNICFKKCVESVNDSNLSSQ 60 EEQCLSNCVNRFLDTNIRIVNGLQNTR 87 SEQIDNO:7 atgtcatcagatatcagagacgtagaggaacgaaattcgcggagctcgagctcaagctcg 60 agctcgaactctgccgcccaatccattggacagcatccataccgcggtttcgacagcgaa 120 gccgcggaaagggtgcatgagttggctagaacactcacatcgcagagtttactatacact 180 gctaactcaaacaatagctcttccagcaaccataatgcgcacaatgcggactcgagatcc 240 gtattttctacggacatggaaggtgtgaacccggtgttcactaacccggacaccccggga 300 tacaatcccaaattggaccctaacagtgatcaattctccagtacggcgtgggtacagaac 360 atggcaaatatttgtacttcggacccggatttctataaaccatactcactcggttgtgta 420 tggaagaatctaagcgcctccggagactccgccgatgtgtcataccagtcaactttcgct 480 aacatcgtaccaaagctgcttacgaaagggctcagattactgaagcccagtaaagaagag 540 gacacttttcagatcctgaaacccatggatggttgtcttaatcccggtgaactgttggtt 600 gttcttgggagaccagggtcaggttgtactacgctgctaaaatccatatcttctaattcg 660 cacgggttcaagatcgcaaaagactccattgtctcttacaacggtttgtcaagctcggat 720 atcaggaaacattaccgtggtgaagtcgtttacaatgcggaatcagatattcatttaccg 780 catcttaccgtgtaccagacgcttttcaccgtggcaaggatgaaaacgccgcaaaatcgt 840 atcaagggtgttgatagagaagcgtacgccaatcacgtgacagaagttgcaatggccaca 900 tatggtctttcgcatacaagggacaccaaggtcggaaacgatctagtcagaggtgtttct 960 ggtggtgaaagaaagcgtgtatccattgcggaagtcgcaatctgcggcgccagatttcaa 1020 tgttgggataatgccaccagaggtttggactctgctactgctttagaattcatccgtgct 1080 ttaaaaacccaggctgacattggaaagaccgcggctactgtggccatctatcaatgttct 1140 caggatgcttatgatctttttgataaggtctgtgtcctggatgatggttaccagctttat 1200 tttgggcccgctaaggatgcaaagaaatatttccaagacatgggctactattgtcctccc 1260 agacagaccactgcagattttttaacttcaattacaagtcctactgaaagaattattagc 1320 aaagaatttatcgaaaaaggtactagagtgcctcaaacgccaaaggatatggccgaatat 1380 tggctacaatcagaaagctacaaaaatttaatcaaggatatagactctacattagagaaa 1440 aacacagatgaagcacgcaatattatcagggatgctcaccacgctaaacaggcaaaaagg 1500 gcaccaccttcctctccatacgttgtcaactacggaatgcaagtcaaatacttgttgatt 1560 agaaatttctggagaatgaagcaaagtgctagtgttactttgtggcaagtcatcggtaac 1620 tctgtcatggctttcatcttgggttctatgttttataaagtgatgaagaaaaacgatact 1680 tccactttctatttccgtggtgctgcaatgttttttgctattttatttaatgcattttcg 1740 tgtcttttggaaatctttagtttgtatgaaacaagacctataactgaaaaacacagaact 1800 tattccttgtatcatccaagcgctgacgcatttgcgtctgttttgtcagaaatgccgcca 1860 aaattgatcactgctgtctgcttcaacatcatcttttatttcctagttgatttcaggaga 1920 aacggtggtgtctttttcttttattttttaattaatgtcattgccacattcactttatcc 1980 catttatttagatgcgtgggctccttgaccaaaacattacaggaggccatggtccccgct 2040 tcaatgttattattggcaatttctatgtatacagggtttgccatccctaaaacgaagatt 2100 ttaggttggtccatttggatttggtatatcaacccgctagcctacctgtttgaatcttta 2160 atgatcaatgaattccatgaccgtagattcccttgtgcccaatacatccctgctggccct 2220 gcttatcagaacatcacaggtactcaacgcgtctgttccgcagttggtgcttatccaggt 2280 aacgactatgtgttgggtgatgacttcttgaaggaaagttacgattatgagcacaaacat 2340 aagtggcgtgggttcggtattggtatggcatatgttgttttctttttctttgtttatcta 2400 attctttgtgagtataatgaaggtgctaaacaaaagggtgaaatggttgtgttcctaaga 2460 tctaagatcaagcaattgaaaaaggaaggtaaattacaagaaaagcataggcctggagat 2520 attgaaaataatgcaggcagttctccagattccgctacaacagaaaaaaaaatactagat 2580 gatagttctgagggatcggatagctcttcagataatgccggattaggactttccaaatct 2640 gaagcaattttccactggcgtgatttatgctatgatgttcctataaaaggaggtcaaaga 2700 cgtatcttaaataacgtagatggttgggtaaaaccaggcactttgactgccttaatgggg 2760 gcgtcaggtgcaggtaaaacaactttactggattgtttggctgaaagagtcaccatgggt 2820 gttattactggtaatatttttgtcgatggtcgtctccgtgacgaatcattccctagatct 2880 attggttattgtcaacaacaggatttacatttgaaaacggctacagtaagagaatctttg 2940 agattttcagcttatttacgtcagccttcgtcagtttctattgaagaaaaaaataggtac 3000 gtggaagaagttatcaaaattttggaaatgcaacaatattcagatgctgttgttggtgtt 3060 gcaggtgaaggtctaaatgtcgaacaaagaaaaagacttactattggtgttgaactagcg 3120 gcaaggcctaaacttttggtttttttggatgaaccaacttcaggcctggattcacaaact 3180 gcttgggacacttgccaacttatgaggaaactagctacccacggtcaagcaattttgtgt 3240 actatccatcaaccttctgctatattaatgcagcagtttgatagattattatttttacag 3300 aaagggggccaaactgtatatttcggcgatttaggtgaagggtgcaaaactatgatcgat 3360 tattttgaaagtaaaggagctcacaaatgtccacctgatgcaaaccctgccgaatggatg 3420 ttagaggttgtaggtgccgctcctggttctcacgctacgcaagattataatgaagtctgg 3480 agaaactcagatgaatacaaagctgttcaggaagaattggattggatggaaaagaattta 3540 ccaggcaggtcaaaagaaccaactgcagaagaacataaaccttttgctgcatctttatac 3600 taccaatttaaaatggttaccattcgtttgttccaacaatactggagatcaccagattat 3660 ttatggtcgaaatttattttgactattttcaaccaagtttttattgggttcacttttttc 3720 aaggctgacagaagtttacagggactacaaaaccaaatgttatcaatattcatgtatacg 3780 gttattttcaatcctatactacaacagtatctaccatctttcgtgcagcaaagggatttg 3840 tatgaggcaagagaacgtccttcaagaacattttcgtggcttgcgtttttcctctctcaa 3900 atcattgttgaaatcccatggaatattttagcgggtacgattgcttattgtatttactat 3960 tacgcggttggattttatgcgaacgcctcagctgctggtcaactccatgagagaggtgct 4020 ttgttttggttattttctattgccttctacgtctacattggttcgatgggtttgttaatg 4080 atttctttcaatgaagttgctgaaacagcggcacatatgggaacgctattgttcacgatg 4140 gcattatctttctgtggtgttatggctacccctaaggttatgccaagattttggatcttt 4200 atgtatagagtgtcacccctaacttatatgatcgatgcattattagcccttggtgtggct 4260 aatgtggacgttaagtgttcaaattatgaaatggtaaaatttactccaccatctggaacc 4320 acctgcggtgactatatggcatcatatatcaagttggccggaacaggctacttgagtgac 4380 ccgtctgcaacagatatatgtagtttctgtgcggtatccaccaccaatgcctttttggcc 4440 actttcagttctcattattacagaagatggagaaattacggtatttttatctgctatatt 4500 gcttttgattatatcgctgcaacattcttgtattggttatccagggtacccaagaagaac 4560 ggtaagatttccgaaaaacccaagaagtga 4590 SEQIDNO:8 MSSDIRDVEERNSRSSSSSSSSNSAAQSIGQHPYRGFDSEAAERVHELARTLTSQSLLYT 60 ANSNNSSSSNHNAHNADSRSVFSTDMEGVNPVFTNPDTPGYNPKLDPNSDQFSSTAWVQN 120 MANICTSDPDFYKPYSLGCVWKNLSASGDSADVSYQSTFANIVPKLLTKGLRLLKPSKEE 180 DTFQILKPMDGCLNPGELLVVLGRPGSGCTTLLKSISSNSHGFKIAKDSIVSYNGLSSSD 240 IRKHYRGEVVYNAESDIHLPHLTVYQTLFTVARMKTPQNRIKGVDREAYANHVTEVAMAT 300 YGLSHTRDTKVGNDLVRGVSGGERKRVSIAEVAICGARFQCWDNATRGLDSATALEFIRA 360 LKTQADIGKTAATVAIYQCSQDAYDLFDKVCVLDDGYQLYFGPAKDAKKYFQDMGYYCPP 420 RQTTADFLTSITSPTERIISKEFIEKGTRVPQTPKDMAEYWLQSESYKNLIKDIDSTLEK 480 NTDEARNIIRDAHHAKQAKRAPPSSPYVVNYGMQVKYLLIRNFWRMKQSASVTLWQVIGN 540 SVMAFILGSMFYKVMKKNDTSTFYFRGAAMFFAILFNAFSCLLEIFSLYETRPITEKHRT 600 YSLYHPSADAFASVLSEMPPKLITAVCFNIIFYFLVDFRRNGGVFFFYFLINVIATFTLS 660 HLFRCVGSLTKTLQEAMVPASMLLLAISMYTGFAIPKTKILGWSIWIWYINPLAYLFESL 720 MINEFHDRRFPCAQYIPAGPAYQNITGTQRVCSAVGAYPGNDYVLGDDFLKESYDYEHKH 780 KWRGFGIGMAYVVFFFFVYLILCEYNEGAKQKGEMVVFLRSKIKQLKKEGKLQEKHRPGD 840 IENNAGSSPDSATTEKKILDDSSEGSDSSSDNAGLGLSKSEAIFHWRDLCYDVPIKGGQR 900 RILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGNIFVDGRLRDESFPRS 960 IGYCQQQDLHLKTATVRESLRFSAYLRQPSSVSIEEKNRYVEEVIKILEMQQYSDAVVGV 1020 AGEGLNVEQRKRLTIGVELAARPKLLVFLDEPTSGLDSQTAWDTCQLMRKLATHGQAILC 1080 TIHQPSAILMQQFDRLLFLQKGGQTVYFGDLGEGCKTMIDYFESKGAHKCPPDANPAEWM 1140 LEVVGAAPGSHATQDYNEVWRNSDEYKAVQEELDWMEKNLPGRSKEPTAEEHKPFAASLY 1200 YQFKMVTIRLFQQYWRSPDYLWSKFILTIFNQVFIGFTFFKADRSLQGLQNQMLSIFMYT 1260 VIFNPILQQYLPSFVQQRDLYEARERPSRTFSWLAFFLSQIIVEIPWNILAGTIAYCIYY 1320 YAVGFYANASAAGQLHERGALFWLFSIAFYVYIGSMGLLMISFNEVAETAAHMGTLLFTM 1380 ALSFCGVMATPKVMPRFWIFMYRVSPLTYMIDALLALGVANVDVKCSNYEMVKFTPPSGT 1440 TCGDYMASYIKLAGTGYLSDPSATDICSFCAVSTTNAFLATFSSHYYRRWRNYGIFICYI 1500 AFDYIAATFLYWLSRVPKKNGKISEKPKK 1529 SEQIDNO:9 atggctaacgacgctctaagtgctattttcagtaatccttcgaggaaaggtgtccaaccc 60 tccacatctattgtgtcatatacaaacaatgaagatgatattatagatgtggaaaatggg 120 aagttcaacaagaacaagaatatcaacactaatgtgtatgtggacaactcctcaatagag 180 gagagcgaagtcgtgcccttgcccgaaacaaagtccatctggagtaaaatatactacgat 240 ttcattgtgttagacaagacaactttgaatgtttcgttgaaagagtcgttcttgtataac 300 agagacttgaaaccggttgaagaagaaagaaggtgttggtcctggttcaattacttatat 360 ttctggctggcagactgtttcaatattaacacatggcaaatagctggtacaggtctacaa 420 ctaggtctgaattggtggcaatgttggcttacagtttggatcggctacacttttgcaggt 480 atcttcgtagtattgaactcgagatttggttccgcatatcacttatctttccctattact 540 gttagggcctcatttggtatattcttttctatgtggccgattataaatcgtgtcgtgatg 600 gctatagtatggtatgccgtgcaagcctggttaggtgcaacgcccgtggcactgatgcta 660 aaatctatttttggcaagaatctggaagatagaatcccaaaccattttggttctccaaat 720 agcactacttttgaattcatgtgtttctttatattttgggtggtcagtataccatttgtc 780 ctagtggctcctcataaaatcaggcatttattcacagtaaaagcagctttgatccccttc 840 gcagcctttggatttttaatctgggctttgaagaaatcgcacggtaaaattgagttgggg 900 acgctgaatgattattcacctcatggttccgaattttcatggatattcgttagatcccta 960 atggcctgtgttgctaactttgccgctttgattatcaacgcccctgacttcggtagattt 1020 gccaaaaatcctcaagcgtctttgtggccacaattggttgccatcccattgttcttcgcc 1080 ataacatgtttgatcggtatcattgttactgcggccggttatcacttatatggggttaac 1140 tattggtcaccactggatgtacttggtcaatttttggagaccacttacaccagaggtact 1200 agggctggtgtgttcttgatttcttttgtatttgccttagctcaactgggtacaaacatt 1260 tctgccaactctctggcatgtggtgctgatatgacggctttgtttccaagatatattaat 1320 attagaagaggttctttattctgtgtggcaatggctctatgtatctgtccatggaactta 1380 atggccagttcaagtaagttcaccagcgctttgggtgcttatgcaattttcctttccagt 1440 attgctggtgtcatttgcgcggattatttcgtagtaagaagaggatatgtgaaattaaca 1500 catttattcctggcacagaagggttccttttacatgtttggaaacaaatttggtgccaat 1560 tggagggcctttgttgcgtatatttgcggtatcgctccaaatttaccaggttttataggt 1620 gatgttggagctccaaaaattacggtttcagagggtgcaatgaggttatactatttaggt 1680 tatccggtaggtttctttattagtgcggtgatatacctcatattatgttacttttttcct 1740 gtccctggtactcccgtaaccaattttctgacagagaaaggatggttccaaagatgggct 1800 tatgttgaggacttcgagcaagattggaagaatgagttacgtagggatgacctctgcgat 1860 gacacagtcagtatctatgatggcaccgaggaaaagatagtttactaa 1908 SEQIDNO:10 MANDALSAIFSNPSRKGVQPSTSIVSYTNNEDDIIDVENGKFNKNKNINTNVYVDNSSIE 60 ESEVVPLPETKSIWSKIYYDFIVLDKTTLNVSLKESFLYNRDLKPVEEERRCWSWFNYLY 120 FWLADCFNINTWQIAGTGLQLGLNWWQCWLTVWIGYTFAGIFVVLNSRFGSAYHLSFPIT 180 VRASFGIFFSMWPIINRVVMAIVWYAVQAWLGATPVALMLKSIFGKNLEDRIPNHFGSPN 240 STTFEFMCFFIFWVVSIPFVLVAPHKIRHLFTVKAALIPFAAFGFLIWALKKSHGKIELG 300 TLNDYSPHGSEFSWIFVRSLMACVANFAALIINAPDFGRFAKNPQASLWPQLVAIPLFFA 360 ITCLIGIIVTAAGYHLYGVNYWSPLDVLGQFLETTYTRGTRAGVFLISFVFALAQLGTNI 420 SANSLACGADMTALFPRYINIRRGSLFCVAMALCICPWNLMASSSKFTSALGAYAIFLSS 480 IAGVICADYFVVRRGYVKLTHLFLAQKGSFYMFGNKFGANWRAFVAYICGIAPNLPGFIG 540 DVGAPKITVSEGAMRLYYLGYPVGFFISAVIYLILCYFFPVPGTPVTNFLTEKGWFQRWA 600 YVEDFEQDWKNELRRDDLCDDTVSIYDGTEEKIVY 635 SEQIDNO:11 atgagtgatcaagaatctgttgtttcattcaactcacaaaacacttccatggtggacgtt 60 gagggccaacaacctcaacagtatgtcccctcaaaaaccaactctcgtgcaaatcaactt 120 aagttaactaagactgagaccgtcaagtctttacaagatttaggtgtcacttcagccgcc 180 ccagtgcctgatatcaatgcgccacaaactgctaagaataacattttccctgaagaatat 240 accatggaaacaccatctgggctggttccagtggctaccttacaatctatgggtagaacc 300 gcctctgccttatctcgtactagaacaaagcaattgaaccgtaccgctaccaattcctca 360 tccacaggtaaagaagaaatggaagaggaagaaactgaagaacgtgaagaccagagcggt 420 gaaaacgagctagatccagagatcgaattcgttacttttgttactggtgatccagaaaac 480 cctcacaattggccctcatgggttcgttggagttacactgtcctgttgtccatcttagtt 540 atttgcgttgcctacggttctgcttgtatcagtggtgggttgggaaccgttgaaaagaaa 600 taccatgtaggtatggaagccgctattttatcatgttctttaatggttattgggttctcg 660 ctgggtcctttgatttggtctcctgttagtgatctttacggtagaagagttgcttacttt 720 gtttctatgggtctttatgtcatcttcaatatcccttgcgccttagctccaaatctaggt 780 tgtcttttagcttgtagatttttatgtggtgtttggtcatcatctggtttgtgtttagtt 840 ggtgggtctattgccgatatgttcccaagtgaaacaagaggtaaggctattgctttcttc 900 gcttttgctccttacgttggtcccgttgttggtccactagttaacggttttatttccgtt 960 tctaccggacgtatggacctgattttctgggtcaatatggcctttgcaggtgttatgtgg 1020 atcatatcttctgccatcccagaaacgtacgctccagttatcttgaagagaaaggctgct 1080 agattaagaaaggaaactggtaatcccaagattatgactgagcaggaagcgcaaggtgtc 1140 agtatgagtgaaatgatgagggcttgtctgttgagacctttgtacttcgctgtcactgaa 1200 cctgttctagttgccacttgtttctacgtgtgtttgatttactctctactatatgcgttc 1260 ttctttgccttccctgtcattttcggtgaactatatggctacaaagataaccttgtgggt 1320 ttaatgtttattcctattgttatcggtgctctttgggcgttagccacaactttctactgt 1380 gaaaacaaatatttacaaattgtcaaacagcgtaaacctactcctgaagatcgtttgcta 1440 ggtgctaagatcggtgctccatttgctgcaattgctctatggatcctgggtgctaccgct 1500 tataaacatattatttgggttggtccagcttcagctggtttagcttttggtttcggtatg 1560 gtgttgatttattattcattgaataattacattattgattgctacgtccaatacgcatcc 1620 agtgctctggctacaaaggttttcttaagatccgccggtggtgctgccttccccttgttt 1680 accattcaaatgtaccacaaattgaatttgcactggggttcttggttgttggctttcatc 1740 tccactgctatgattgctttaccttttgcattttcttactggggtaagggcttgagacat 1800 aagttgtccaagaaggactattccatcgacagtgttgagatgtaa 1845 SEQIDNO:12 MNRQESINSFNSDETSSLSDVESQQPQQYIPSESGSKSNMAPNQLKLTRTETVKSLQDMG 60 VSSKAPVPDVNAPQSSKNKIFPEEYTLETPTGLVPVATLHSIGRTSTAISRTRTRQIDGA 120 SSPSSNEDALESDNNEKGKEGDSSGANDEAPDLDPEIEFVTFVTGDPENPHNWPAWIRWS 180 YTVLLSILVICVAYGSACISGGLGTVEKKYHVGMEAAILSVSLMVIGFSLGPLIWSPVSD 240 LYGRRVAYFVSMGLYVIFNIPCALAPNLGSLLACRFLCGVWSSSGLCLVGGSIADMFPSE 300 TRGKAIAFFAFAPYVGPVVGPLVNGFISVSTGRMDLIFWVNMAFAGVMWIISSAIPETYA 360 PVILKRKAARLRKETGNPKIMTEQEAQGVSMGEMMRACLLRPLYFSVTEPVLVATCFYVC 420 LIYSLLYAFFFAFPVIFGELYGYKDNLVGLMFIPIVIGALWALATTFYCENKYLQIVKQR 480 KPTPEDRLLGAKIGAPFAAIALWILGATAYKHIIWVGPASAGLAFGFGMVLIYYSLNNYI 540 IDCYVQYASSALATKVFLRSAGGAAFPLFTIQMYHKLNLHWGSWLLAFISTAMIALPFAF 600 SYWGKGLRHKLSKKDYSIDSIE 622 SEQIDNO:13 atgactgatcgtaaaaccaacttgccagaagaaccgattttcgaagaggcagaagatgat 60 ggctgcccttcgatagaaaattcttcacatctgtcagtacctacagtggaggaaaacaag 120 gacttttccgagtataatggggaagaggcagaggaagttgttgttccagaaaagcctgct 180 tcagcctatgctactgtttctatcatgtgtttatgtatggctttcggtggatttatgtcc 240 ggttgggacacaggtacgatttctggtttcgtcaatcagactgattttttaagaagattt 300 ggtaattatagccattccaagaacacttactacttatctaatgtgagaactgggttgatt 360 gtgtccatcttcaatgtgggaagcgccattggctgtcttttcttgtctaaattgggtgat 420 atttacggccgctgcatgggtttgattatagttattgtcgtttatatggttggtattgtc 480 attcaaattgcctctatagataagtggtatcagtattttattggaagaattatcgctggt 540 ataggtgctggttccattagtgttcttgccccgatgcttatttcggaaactgcgccaaag 600 catatcagaggtacgttgctagcttgttggcaattgatggtgactttcgcaattttcttg 660 ggttattgtaccaattatggtaccaagacttactcgaattctgtccagtggcgtgttccg 720 cttggtctatgttttgcatgggctattattatgattggtggtatgacgtttgttccggaa 780 tctcctcggtttttggtgcaagtcggtaagattgagcaagctaaagcttcttttgccaag 840 tcgaacaagcttagtgttgacgatcctgctgtggttgcagagattgatcttcttgttgct 900 ggtgtggaggcagaagaagcaatgggaactgcttcatggaaggaattattttcgagaaag 960 actaaagtttttcaacgtttaacgatgacagtcatgattaactctctgcagcaactaacc 1020 ggtgacaactatttcttctactacggtactactatcttcaaatctgtcggtatgaatgac 1080 tcttttgagacttcaattgtcttgggtattgtgaattttgcttcttgcttcttttcactt 1140 tattctgttgataagttgggccgtcgtagatgtcttttacttggagcagccaccatgacg 1200 gcgtgcatggttatttacgcctccgttggcgtcacaagactatatccgaacggtaaaagt 1260 gaaccatcatctaaaggtgctggtaattgtacgattgttttcacgtgtttttacattttc 1320 tgcttttcctgcacctggggacctgtatgttatgtgattatttctgaaacatttccatta 1380 agggtgagatccaagtgtatgtccgttgcaacagcggccaacttattgtgggggttccta 1440 atcgggtttttcactccttttattacttcggcaattaatttctactacggttacgttttc 1500 atgggttgcttagcgttttcatatttttacgtctttttctttgttccagaaacaaaaggt 1560 ctaactttagaagaagttgatgagatgtggatggacggtgtattaccttggaaatctgaa 1620 tcctgggtaccagcttctagaagggatggtgattatgataacgaaaaattacagcatgac 1680 gagaaacccttctacaaaagaatgttttag 1710 SEQIDNO:14 MTDRKTNLPEEPIFEEAEDDGCPSIENSSHLSVPTVEENKDFSEYNGEEAEEVVVPEKPA 60 SAYATVSIMCLCMAFGGFMSGWDTGTISGFVNQTDFLRRFGNYSHSKNTYYLSNVRTGLI 120 VSIFNVGSAIGCLFLSKLGDIYGRCMGLIIVIVVYMVGIVIQIASIDKWYQYFIGRIIAG 180 IGAGSISVLAPMLISETAPKHIRGTLLACWQLMVTFAIFLGYCTNYGTKTYSNSVQWRVP 240 LGLCFAWAIIMIGGMTFVPESPRFLVQVGKIEQAKASFAKSNKLSVDDPAVVAEIDLLVA 300 GVEAEEAMGTASWKELFSRKTKVFQRLTMTVMINSLQQLTGDNYFFYYGTTIFKSVGMND 360 SFETSIVLGIVNFASCFFSLYSVDKLGRRRCLLLGAATMTACMVIYASVGVTRLYPNGKS 420 EPSSKGAGNCTIVFTCFYIFCFSCTWGPVCYVIISETFPLRVRSKCMSVATAANLLWGFL 480 IGFFTPFITSAINFYYGYVFMGCLAFSYFYVFFFVPETKGLTLEEVDEMWMDGVLPWKSE 540 SWVPASRRDGDYDNEKLQHDEKPFYKRMF 569 SEQIDNO:15 atgaattcaactccagatttaatatctccacaaaagtcaagtgagaattcgaatgctgac 60 ctgccttcgaatagctctcaggtaatgaacatgcctgaagaaaaaggtgttcaagatgat 120 ttccaagctgaggccgaccaagtacttaccaacccaaatacaggtaaaggtgcatatgtc 180 actgtgtctatctgttgtgttatggttgccttcggtggtttcgttttcggttgggatact 240 ggtaccatttctggtttcgtcgcccaaactgatttcttgagaagattcggtatgaagcat 300 aaagatggtagttattatttgtctaaggttagaactggtttaattgtctccattttcaac 360 attggttgtgccattggtggtattattttggctaaattgggtgatatgtacggtcgtaaa 420 atgggtttgattgtcgttgttgttatctacatcatcggtattattattcaaattgcatcc 480 atcaacaaatggtaccaatatttcatcggtagaattatttccggtttgggtgttggtggt 540 attgccgttttatctcctatgttgatttctgaagtcgctcctaaggaaatgagaggtact 600 ttagtctcctgttaccaactgatgattaccttgggtattttcttgggttactgtaccaac 660 ttcggtactaagaactactccaactctgtgcaatggagagttccattaggtttgtgtttt 720 gcctgggctttgtttatgatcggtggtatgactttcgttccagaatccccacgttatttg 780 gttgaagctggtcaaattgacgaagcaagagcatctctttccaaagttaacaaggttgcc 840 ccagaccatccattcattcaacaagagttggaagttattgaagctagtgttgaagaagct 900 agagctgctggttcagcatcatggggtgagttgttcactggtaagccggccatgtttaag 960 cgtactatgatgggtatcatgatccaatctctacaacaattgactggtgataactatttc 1020 ttctactatggtactaccgtttttaacgctgttggtatgagtgattctttcgaaacttct 1080 attgttttcggtgtcgtcaacttcttctctacttgttgttctttgtacactgtcgatcgt 1140 tttggacgtcgtaactgtttgttatatggtgccattggtatggtctgctgttatgtagtt 1200 tacgcttctgttggtgtcaccagactatggccaaatggtgaaggtaatggttcatccaag 1260 ggtgctggtaactgtatgattgtctttgcctgtttctatattttctgttttgctaccact 1320 tgggctccaattgcttatgttgttatttctgaaactttcccattgagagtcaagtctaag 1380 gctatgtctattgctacagctgctaattggttgtggggtttcttgattggtttcttcact 1440 ccatttattactggtgctattaacttctactacggttacgttttcatgggctgtatggtt 1500 ttcgcctacttctacgttttcttctttgtgccagaaactaagggtttgactttggaagaa 1560 gtcaatgatatgtacgctgaaggtgttctaccatggaagtctgcttcatgggttccaaca 1620 tctcaaagaggtgctaactacgatgctgatgcattgatgcatgatgaccagccattctac 1680 aagaaaatgttcggcaagaaataa 1704 SEQIDNO:16 MNSTPDLISPQKSSENSNADLPSNSSQVMNMPEEKGVQDDFQAEADQVLTNPNTGKGAYV 60 TVSICCVMVAFGGFVFGWDTGTISGFVAQTDFLRRFGMKHKDGSYYLSKVRTGLIVSIFN 120 IGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGG 180 IAVLSPMLISEVAPKEMRGTLVSCYQLMITLGIFLGYCTNFGTKNYSNSVQWRVPLGLCF 240 AWALFMIGGMTFVPESPRYLVEAGQIDEARASLSKVNKVAPDHPFIQQELEVIEASVEEA 300 RAAGSASWGELFTGKPAMFKRTMMGIMIQSLQQLTGDNYFFYYGTTVFNAVGMSDSFETS 360 IVFGVVNFFSTCCSLYTVDRFGRRNCLLYGAIGMVCCYVVYASVGVTRLWPNGEGNGSSK 420 GAGNCMIVFACFYIFCFATTWAPIAYVVISETFPLRVKSKAMSIATAANWLWGFLIGFFT 480 PFITGAINFYYGYVFMGCMVFAYFYVFFFVPETKGLTLEEVNDMYAEGVLPWKSASWVPT 540 SQRGANYDADALMHDDQPFYKKMFGKK 567 SEQIDNO:17 atgatttggattatgactatggcccgtagaatgaacggcgtctacgctgcttttatgttg 60 gttgctttcatgatgggtgttgccggtgctttgcaagctccaactttgtctttatttttg 120 tccagagaagtcggtgctcaaccattctggatcggcttgttctacaccgtcaacgctatt 180 gctggtattggcgtttctttgtggttagctaagaggtctgactctcagggtgataggaga 240 aagctgattatcttctgttgcttgatggctattggcaacgctctattgttcgccttcaac 300 agacattacctgactctgatcacttgtggcgtcttgttggcttctttggctaatactgct 360 atgccacaactattcgctttggctcgtgaatacgctgacaattctgctcgcgaagtggtt 420 atgttctcatctgttatgagggctcaattgtctttggcatgggttattggtccaccattg 480 gcattcatgctggctttgaactacggcttcaccgttatgttttccattgctgcaggcatc 540 ttcaccttgtctctagttctgatcgcctttatgttaccctccgtcgctagagttgaattg 600 ccatctgaaaatgctttgtctatgcaaggtggttggcaagactccaacgtcagaatgttg 660 ttcgttgcttctaccttgatgtggacctgcaacaccatgtacatcatcgatatgcccttg 720 tggatttcctctgaattgggtttgccagacaagttagctggttttttgatgggtactgct 780 gctggtttggagattccagctatgatcttggccggttactacgttaaacgctatggtaag 840 aggagaatgatggttatcgctgttgctgccggcgttttgttttacactggcctgatcttg 900 ttccattctaggctggctctgatgactttgcaattgtttaatgctgtcttcatcggtatc 960 gtcgccggtataggcatgttgtggtttcaggatttgatgccaggtagagctggtgctgct 1020 accactttgtttaccaattctatttctactggcgtcattttggctggtgtcattcaaggt 1080 gccatcgctcaatcctggggtcacttcgctgtttattgggtcattgctgttatttccgtt 1140 attgccttgttcctgactgctaaagtcaaggatgtttaa 1179 SEQIDNO:18 MIWIMTMARRMNGVYAAFMLVAFMMGVAGALQAPTLSLFLSREVGAQPFWIGLFYTVNAI 60 AGIGVSLWLAKRSDSQGDRRKLIIFCCLMAIGNALLFAFNRHYLTLITCGVLLASLANTA 120 MPQLFALAREYADNSAREVVMFSSVMRAQLSLAWVIGPPLAFMLALNYGFTVMFSIAAGI 180 FTLSLVLIAFMLPSVARVELPSENALSMQGGWQDSNVRMLFVASTLMWTCNTMYIIDMPL 240 WISSELGLPDKLAGFLMGTAAGLEIPAMILAGYYVKRYGKRRMMVIAVAAGVLFYTGLIL 300 FHSRLALMTLQLFNAVFIGIVAGIGMLWFQDLMPGRAGAATTLFTNSISTGVILAGVIQG 360 AIAQSWGHFAVYWVIAVISVIALFLTAKVKDV 392 SEQIDNO:19 agtccagttacgctggagtcaagcaagcttaaaatgcataattccccagctgtcacttct 60 gccaagtctttcgatttgactagcatggcattcttgattgttgcttttttgaccggcatc 120 gctggtgccttgcaaaccccaactttgtccattttcttgactgatgaagttcacgctaga 180 ccagctatggtgggctttttctttactggttccgccgtcattggtatcctagtctctcaa 240 tttttggccggtaggtctgacaaaaggggtgatagaaaatccctgattgtcttctgctgt 300 ttgttgggtgttttggcctgtaccttgttcgcttggaacaggaactattttgtcctgttg 360 ttcgttggcgtttttctgtcttccttcggttctaccgctaatccccaaatgtttgctttg 420 gctagagaacatgccgacaaaactggtagagaggctgttatgttttcttctttcttgagg 480 gctcaagtttctctggcctgggttattggtccacctttggcttatgctctggctatgggt 540 ttttcctttaccgttatgtatctgtctgctgctgtcgcctttatcgtttgtggtgtcatg 600 gtctggttgtttttgccctctatgcagaaagaattgccattggctactggtactgttgaa 660 gctccaagaaggaataggagagacaccttgttgctgttcgtcatttgcactctgatgtgg 720 ggttccaattccctgtacatcattaacatgccactgttcatcatcaatgagttgcatctg 780 cccgaaaaattggctggtgttatgatgggtactgctgccggcctggaaattccaaccatg 840 ttgattgctggctattttgctaagagattgggcaagaggtttttgatgagggttgctgca 900 gttggtggtgtttgtttttacgctggtatgttgatggctcattctccagtcatcttgtta 960 ggtttgcagttgctgaacgctatcttcatcggtatcttgggcggtattgggatgttgtac 1020 tttcaggatttgatgccaggtcaagctggttctgctactactttgtacactaatacttcc 1080 agagttggttggattatcgccggttctgttgctggcattgtcgctgaaatctggaattac 1140 catgccgtcttttggttcgctatggtcatgatcatcgctaccctgttctgcttgttgagg 1200 attaaagacgtttaaccgcggcatcactgaccatttaaatcatac 1245 SEQIDNO:20 MHNSPAVTSAKSFDLTSMAFLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGS 60 AVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLFAWNRNYFVLLFVGVFLSSFGS 120 TANPQMFALAREHADKTGREAVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAA 180 VAFIVCGVMVWLFLPSMQKELPLATGTVEAPRRNRRDTLLLFVICTLMWGSNSLYIINMP 240 LFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGML 300 MAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPGQAGSATTLYTNTSRVGWIIAGSVA 360 GIVAEIWNYHAVFWFAMVMIIATLFCLLRIKDV 393 SEQIDNO:21 agtccagttacgctggagtcaagcaagcttaaaatgcaaaagactgctactactccatct 60 aaaattctggacttgacagctgctgcttttttgttggttgccttcctgactggtattgcc 120 ggtgctctacaaactccaactttgtccattttcttggctgacgaattgaaagctcgccca 180 attatggtcggtttctttttcactggttccgccatcatggggattctggtttctcaattt 240 ttggctaggcattctgataagcagggcgacaggaagttgttgattttgttgtgttgtttg 300 ttcggcgttttggcctgtaccttgtttgcctggaacaggaactacttcattttgctgtcc 360 actggtgtcttgttgtcttcttttgcttccaccgccaatccacaaatgtttgctttggca 420 agagaacacgctgatagaaccggtagagagactgtcatgttctctacttttctgagagcg 480 caaatctctttggcttgggtcattggtccaccattggcttacgaattggctatgggcttt 540 tctttcaaggtcatgtatttgactgctgccattgctttcgttgtctgtggcttgattgtc 600 tggttgttcttgccatccatccaaaggaatatccccgttgttactcagccagttgaaatt 660 ttgccctctattcacagaaagcgcgatactagattgctgttcgtcgtttgttccatgatg 720 tgggccgccaacaacctgtacatgattaacatgcccctgttcattatcgatgaattgcac 780 ttgactgataaattggctggcgaaatgatcggtatcgctgccggtctggaaattccaatg 840 atgctgattgctggttactacatgaagagaattggtaagaggctattgatgctcatcgcc 900 atcgtctctggtatgtgcttctacgcttctgttttgatggccactactcctgccgttgag 960 ttggaattgcaaattctgaatgccatcttcttgggtatcttgtgcggtattggtatgctg 1020 tactttcaggacctgatgcccgaaaaaatcggttctgctaccactttgtatgctaatact 1080 tccagggtcggttggattatcgctggttctgttgatggtatcatggtcgagatttggtcc 1140 taccatgctttgttttggttggccatcggtatgctcggtattgctatgatctgcctgttg 1200 tttatcaaggacatctaaccgcggcatcactgaccatttaaatcatac 1248 SEQIDNO:22 MQKTATTPSKILDLTAAAFLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSA 60 IMGILVSQFLARHSDKQGDRKLLILLCCLFGVLACTLFAWNRNYFILLSTGVLLSSFAST 120 ANPQMFALAREHADRTGRETVMFSTFLRAQISLAWVIGPPLAYELAMGFSFKVMYLTAAI 180 AFVVCGLIVWLFLPSIQRNIPVVTQPVEILPSIHRKRDTRLLFVVCSMMWAANNLYMINM 240 PLFIIDELHLTDKLAGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASV 300 LMATTPAVELELQILNAIFLGILCGIGMLYFQDLMPEKIGSATTLYANTSRVGWIIAGSV 360 DGIMVEIWSYHALFWLAIGMLGIAMICLLFIKDI 394 SEQIDNO:23 atggtctttattaaggtccatcaattggcttttttgttcggtctgctgggtaatatcgtc 60 tccttcggtgttttcttgtctcccgtcccaaccttttacggtatctataagaagaaatcc 120 tccaagggcttccaatccattccatacatttgtgctttggcttctgctaccctgttgttg 180 ttctacggcatcatgaagacccatgcctacctgattatctctatcaataccttcggttgc 240 ttcatcgagatcagctacctgttcctatacatcatctatgccccaagagaagctaggatc 300 ttcaccttgaagctgattttgatttgtaacattggcggcttgggtctgttgattctactg 360 gttgatctattgatccccaagcaacacagggtttctactgttggttgggtttgtgctgct 420 tattctttggctgtttttgcttctccactgtctgtcatgagaaaggtcattagaaccaag 480 tccgtcgaatacatgccattgttgctgtctttgtctctgactctgaatgctgtcatgtgg 540 ttcttctacggtttgttgatcgaggataagttcattgccatgcccaatatcttgggtttt 600 ctgtttggtattgcccagatgatcctgtacatgatgtaccacgactctaagaagactgat 660 ctgcccaaattgacctctaccgaaaatcaacccactaacatcactaatctgaacgaagtc 720 gctattgttgccgtcgagttgtctgatgctagagctgaaaatgttgaaggttctgttagg 780 ccaatgactccaaattcatctactactgcttaa 813 SEQIDNO:24 MVFIKVHQLAFLFGLLGNIVSFGVFLSPVPTFYGIYKKKSSKGFQSIPYICALASATLLL 60 FYGIMKTHAYLIISINTFGCFIEISYLFLYIIYAPREARIFTLKLILICNIGGLGLLILL 120 VDLLIPKQHRVSTVGWVCAAYSLAVFASPLSVMRKVIRTKSVEYMPLLLSLSLTLNAVMW 180 FFYGLLIEDKFIAMPNILGFLFGIAQMILYMMYHDSKKTDLPKLTSTENQPTNITNLNEV 240 AIVAVELSDARAENVEGSVRPMTPNSSTTA 270 SEQIDNO:25 aagcttaaaatggcccaattgagagccgatgatttgtctttcattttcggtttgttgggc 60 aacatcgtttccttcatggtttttttggctccagttccaaccttctacaaaatctacaag 120 aggaagtcctccgaaggttatcaagctattccatatatggttgctttgttctctgctggc 180 ttgttgttgtattatgcctacttgagaaagaacgcctacctgatcgtttctattaacggt 240 tttggttgcgctatcgaattgacctacatttccttgtttttgttctacgccccaagaaag 300 tctaagatttttactggttggctgatgttgttggaattgggtgctttgggtatggttatg 360 ccaattacttatttgttggccgaaggttcccatagagttatgatagttggttggatttgc 420 gctgctattaacgttgctgtttttgctgctccattgtccattatgagacaagttattaag 480 accaagtccgtcgagtttatgccattcactttgtctttgttcttgaccttgtgtgctact 540 atgtggtttttctacggtttcttcaagaaggacttctacattgccttcccaaacattttg 600 ggtttcttgttcggtatcgtccagatgttgttgtacttcgtttacaaggactccaagaga 660 atcgatgacgaaaaatctgatccagttagagaagccaccaagtctaaagaaggtgttgaa 720 atcatcatcaacatcgaggatgataactctgataacgccttgcaatctatggaaaaggat 780 ttctccagattgaggacctctaagtaaccgcggctcgagtcatgtaa 827 SEQIDNO:26 MAQLRADDLSFIFGLLGNIVSFMVFLAPVPTFYKIYKRKSSEGYQAIPYMVALFSAGLLL 60 YYAYLRKNAYLIVSINGFGCAIELTYISLFLFYAPRKSKIFTGWLMLLELGALGMVMPIT 120 YLLAEGSHRVMIVGWICAAINVAVFAAPLSIMRQVIKTKSVEFMPFTLSLFLTLCATMWF 180 FYGFFKKDFYIAFPNILGFLFGIVQMLLYFVYKDSKRIDDEKSDPVREATKSKEGVEIII 240 NIEDDNSDNALQSMEKDFSRLRTSK 265 SEQIDNO:27 atgggtggtttgtctatggaacatccttgggctttcgcttttggtctgctaggtaacgtc 60 atttctttttcctctttgttggcccccattccaaccttttacaggatttttaagtccaag 120 tccaccgaaggctttcaatccgtcccatacgtcgttgccttattctctgctatgttgtgg 180 atcttttacgccttggttaagactggtgaaggtctgttgatttccattaatgccgccggt 240 tgtgtcattgaaactgtctacatcgtcatgtacttggtttacgctcccagaaaggccaaa 300 atctttactgctaagatcgtcgtcttgttgaacatcaccggtttcggtttgatcttcctg 360 ttgactttgtttgctttccacggtgaaactagagtcgtttctttgggttggatttgtgtc 420 ggtttctccgtctgtgttttcgttgctccattgtctattattggcagagtcatcaagact 480 aagtccgtcgagtatatgccattcaccttgtccttgaccttgactctgtccgccattgtt 540 tggtttttgtatggcttgttgatcaaagacaagtatgttgccttgcccaatattttgggc 600 ttcaccttcggcgtcatccaaatggttctgtacgtcttctacatgaataaaaccccagtc 660 gcttctgaagttaaggaaggtaaggaagcatggaaggctccagctgaagatcatgttgtt 720 gttatcaacgtcggtaagactgataaaggttcttgtgccgaagttagaccagttactgaa 780 atggcttccgctgttgatgttcctagaagatgtgctgctgaagctgctgcagctccaggt 840 gtcgattttgctaggtctgtcgatgttgtttaa 873 SEQIDNO:28 MGGLSMEHPWAFAFGLLGNVISFSSLLAPIPTFYRIFKSKSTEGFQSVPYVVALFSAMLW 60 IFYALVKTGEGLLISINAAGCVIETVYIVMYLVYAPRKAKIFTAKIVVLLNITGFGLIFL 120 LTLFAFHGETRVVSLGWICVGFSVCVFVAPLSIIGRVIKTKSVEYMPFTLSLTLTLSAIV 180 WFLYGLLIKDKYVALPNILGFTFGVIQMVLYVFYMNKTPVASEVKEGKEAWKAPAEDHVV 240 VINVGKTDKGSCAEVRPVTEMASAVDVPRRCAAEAAAAPGVDFARSVDVV 290 SEQIDNO:29 atggctccaaaaatttcaatatccttaaacccaccgtacaacggggagttttatagctct 60 aatgatcaaatgtcagggatagttagtcttcagttaacaaaagcgctatctataaggaaa 120 atttccgtcattctaaaaggattctcagagaccttaacaaaaattgatcaagagtacatg 180 tttcaacagaatggcatgatgatgccgggccaagacaacaaatcctttcatacattaatg 240 aaattcgaacagagagttttccctccagataatgtatggaatgctcttgatggctcctcc 300 aagccgttcaaagttaaaccaggttcatataattatagctttcaatttgacaagtttccc 360 agaaagcctgaatgtctgaaaaatcatacggcaaagacagtagcgtttgtgacaagaagt 420 aatgcccgactcccacctacgttcaatagtcattggcaagaatttaataaaatcgataat 480 ctggatttgtatttttactcttttggaaaagttatatatatggtgcaagttcaattagag 540 ctagggaaatcttcatcttggtttaagccattccataaactgataagggaaatcgagacg 600 ttcgaatttatacctgagccaaaagatcttattatagaacctgatgaagatgacaatgaa 660 gaacttaatgccttcagtaacaatagtagaggaaatagtatggtcaccaacaatgaattt 720 ttcaatagttcaaatttaaaggtgccatcaaaggacgtcaaagtcgttaatggagtcgga 780 tatataaaaagtgacaggaacttttctcaagctaattctatattgatagaaaacggcgac 840 attagatcgagaccggtatcatcagtcacatcaacaagacaatctactcgcctagtaaat 900 ggtatgaaagttttcccatctacttataaaatggggttgcctgatggggaaagcaatatg 960 agaatagaggttagaagtcgagatttgaagcaaatatacaggaaagactacttgtttagg 1020 tctggcagccaaaattttgacaaggtctatgtagtcatggaggggaatatagcaagtttg 1080 agcaaaatgcaaattaccccacttaaactacaactgaacttgctagagactacaacatat 1140 ttatctcagggaatagcgaacggcaattactcttctttgaagctaatcgagattgatttg 1200 aatcagctcaaatccaataaacctcttttggacttaaacgaaatacgagaaaattttgat 1260 ggttctatgtttgaatgtgaattacggttaaaggatcaccccattttaagaaagttggta 1320 tttaatgaagaagactatagacatcgcggcaataggttgtatagtttcaagacatgcacg 1380 ataaaaagaacattcagtttacagctactgatagaatggggaatcaatggaattaggaag 1440 caatctgaagtaaacattgatcctgttcagatcttttgtcaagttagagagcacgttgaa 1500 gctgaagctctgcccagatatgtaccgccaccgacatatactgaaatggcgagttaa 1557 SEQIDNO:30 MAPKISISLNPPYNGEFYSSNDQMSGIVSLQLTKALSIRKISVILKGFSETLTKIDQEYM 60 FQQNGMMMPGQDNKSFHTLMKFEQRVFPPDNVWNALDGSSKPFKVKPGSYNYSFQFDKFP 120 RKPECLKNHTAKTVAFVTRSNARLPPTFNSHWQEFNKIDNLDLYFYSFGKVIYMVQVQLE 180 LGKSSSWFKPFHKLIREIETFEFIPEPKDLIIEPDEDDNEELNAFSNNSRGNSMVTNNEF 240 FNSSNLKVPSKDVKVVNGVGYIKSDRNFSQANSILIENGDIRSRPVSSVTSTRQSTRLVN 300 GMKVFPSTYKMGLPDGESNMRIEVRSRDLKQIYRKDYLFRSGSQNFDKVYVVMEGNIASL 360 SKMQITPLKLQLNLLETTTYLSQGIANGNYSSLKLIEIDLNQLKSNKPLLDLNEIRENFD 420 GSMFECELRLKDHPILRKLVFNEEDYRHRGNRLYSFKTCTIKRTFSLQLLIEWGINGIRK 480 QSEVNIDPVQIFCQVREHVEAEALPRYVPPPTYTEMAS 518 SEQIDNO:31 atggcattttcacgtcttacatctactcatcagtccaatcataacggctacagtaatagc 60 aacaaaaaaggacaaagtcttccactaaccctttctattgatgtagaatcaccgccatgt 120 gttctttatgggtctgctatggaatcctcaggtgctgtgctaagtggactttttactgtg 180 acggttgtcgatccctacagtagtgctgaagataaatctttaaagaatacagaatctaat 240 gtgtcgactacttctaaaagcctaaaaagaaagagtacatttggttctgcactttcatct 300 agattgtccagcttgtcagcgtcgacgtcaaatatctctccttcaacatcttctacatcc 360 atatcgcattctcccacgcctgctaatttaagaataatggctggttataccaagatcacc 420 attacgtcggtaacactaagtttggtacagaagatccatttccataaaccctttgtgcct 480 aatatttcctcaatgcaaacctgtatgaactgtaaaacaaagattacaaacatgaaaagc 540 tgggaaattcagagtaatacccaggatctttctgttggaagccactcttacccattttcc 600 tatcttataccggggtctgtcccatgttcttcatcgctaggtgctacggctgaaacccag 660 gtcaaatacgaacttatcgctgttgtgacgtatatagatcctcatagaaattccttttct 720 tccggtcattctactcccaggaaagaaggaagctcttctaagaagcggttgttgcaacta 780 gcgatgcccatcgccgtgactcgaagtataccgcgcgggcctgataagaattctctaaga 840 gtatttcctcctacagagttaactgctgctgctgttcttcctaatgttgtatatcctaaa 900 tctacttttcctttggagatgaaattagacggtgtttcttcgggggataggagatggcga 960 atgcgtaaattgagttggagaattgaagaaactacaagagttaaagcacatgcttgtcca 1020 gtgcacaagcatgaattgaggcagttagaagagcaggttaaaataaaagagtcagaaaaa 1080 agtaaaaagccacgcagtcatattaagcgttatggtgaactaggcccacaaatccgggtt 1140 gcagtaaactctttagaaaatatgccgtcgcaaaggcttccaggcgagcccggtcgtgaa 1200 caagcacctaattcttcgggtccagcgtcaactggtaatgttggacttgatgatgaaaat 1260 cctgttaatgaagatgaggaagaccaacccggtagcgaattcatccatcccagtgacgac 1320 gctttgcgtcaggagttactaatgcagcaacaacgcgcaagacaacaacaacttcaacaa 1380 gagctaaaaaacaacagtagtttatttacggaagaggttcggataatatctaagggagaa 1440 atgaagagtggatggaaaaccgattttgacaataatggaaagattgagctagttacagaa 1500 atagattgtatgggacttaattcaggcgtctctaatccggtaatgcatgcatcgacacta 1560 caaactccttccacgggcaataagaagcccagcatcaatgtggcttgcgatatacaggat 1620 ccaaatttaggtttgtatgtaagccacatcttggcagtggaaatagttgttgcagaagaa 1680 acattgcaatatgccaatgggcaacctatacggaaaccaaactccaaaaacaagaaagaa 1740 actaataacaatacgatgaatgttcataatcctgatcaacgcttagctgaattatctcca 1800 atttttgcaaatagaaatacaccgaaagtacggcgcatggggcctgaagatataacaccg 1860 gtgaatagtaataagtccaaccatagtactaataaggagaaggcatctaacggtgctagt 1920 aactctaatatagtgagtgttcccactggtgcagcacgtgttttaagaatgcaattcaga 1980 ttaacagtcactgaaagatctggacttggaatctcctgggacgaagaagttcctcccatt 2040 taccaagatgtcgagttgctctcgccaccatgttacgagctctctataaataatggaatc 2100 aaaaataaactttattcaacaatgagtactcctgttagatcagaggatgattttgtgggc 2160 ggcagcgatgaagatattgggaactatgagagccaagggctcgaacctggtcctaacgta 2220 caggaagtaacgatcacacaaaataaattaacgataccaccaaccgcacatcactaccag 2280 cctgcttcctcttcgcaaagatcccttaccacagtacagtcaccaccactggaaagtgtt 2340 gttagtgtccagggtagtgtaccttttcgtggacatgtgttgacaccacatagcacaaga 2400 gatatcagaatacaaaacttttccgattttctagattccaatagaataacccagtag 2457 SEQIDNO:32 MAFSRLTSTHQSNHNGYSNSNKKGQSLPLTLSIDVESPPCVLYGSAMESSGAVLSGLFTV 60 TVVDPYSSAEDKSLKNTESNVSTTSKSLKRKSTFGSALSSRLSSLSASTSNISPSTSSTS 120 ISHSPTPANLRIMAGYTKITITSVTLSLVQKIHFHKPFVPNISSMQTCMNCKTKITNMKS 180 WEIQSNTQDLSVGSHSYPFSYLIPGSVPCSSSLGATAETQVKYELIAVVTYIDPHRNSFS 240 SGHSTPRKEGSSSKKRLLQLAMPIAVTRSIPRGPDKNSLRVFPPTELTAAAVLPNVVYPK 300 STFPLEMKLDGVSSGDRRWRMRKLSWRIEETTRVKAHACPVHKHELRQLEEQVKIKESEK 360 SKKPRSHIKRYGELGPQIRVAVNSLENMPSQRLPGEPGREQAPNSSGPASTGNVGLDDEN 420 PVNEDEEDQPGSEFIHPSDDALRQELLMQQQRARQQQLQQELKNNSSLFTEEVRIISKGE 480 MKSGWKTDFDNNGKIELVTEIDCMGLNSGVSNPVMHASTLQTPSTGNKKPSINVACDIQD 540 PNLGLYVSHILAVEIVVAEETLQYANGQPIRKPNSKNKKETNNNTMNVHNPDQRLAELSP 600 IFANRNTPKVRRMGPEDITPVNSNKSNHSTNKEKASNGASNSNIVSVPTGAARVLRMQFR 660 LTVTERSGLGISWDEEVPPIYQDVELLSPPCYELSINNGIKNKLYSTMSTPVRSEDDFVG 720 GSDEDIGNYESQGLEPGPNVQEVTITQNKLTIPPTAHHYQPASSSQRSLTTVQSPPLESV 780 VSVQGSVPFRGHVLTPHSTRDIRIQNFSDFLDSNRITQ 818 SEQIDNO:33 atgccgtttataacatcaagaccggtggcgaaaaattcatcccactctttatcagaaaca 60 gatttaaaccagtctaaaggacagccgtttcaaccctctcccaccaagaaattagggtcc 120 atgcaacaacgaagaagatcctccaccattaggcacgcgctatcatctttacttggtggc 180 gctaatgttcactcacctgccgtcttgaacaacacaacgaaaggcggcaataataacggc 240 aacatcagaagcagcaatacagacgcccaactccttggcaaaaaacagaacaaacagccg 300 ccgccaaacgcaaggcgacacagtaccactgccatacagggctctatcagcgatagtgct 360 actacgactccgagatcctcgacttccgacaccaaccgtcgcacttcgggaagattgtcg 420 gtagaccaagagcccagaatctctgggggacgctattcacagattgaggaggatagcaca 480 gtactagattttgatgatgaccataactcatcagctgtagtgtcaagcgatttatcatca 540 acttctctaacaaggttggcaaactcgaaaaagtttaacgagcaatttctcatagaatat 600 ttaaccgctagaggtctcctgggcccaaaaaccgttctatccaatgagtacttgaagatt 660 tctatttctacaagcggtgaaagcgttttcttaccaacgatatcctcgaatgacgatgag 720 tacctgtccagactaaacggactcaatgatggtacggacgatgctgaggcggattttttt 780 atggatggtatagaccagcaagaaggtaacactccatctctcgctacaacggcagcggct 840 accgaaagtggtggcagcataaatgaaaatagagacacactcctgagagaaaataattca 900 ggagaccatccaggctccggctcggaacttaatacaaggtctgttgaaatcgacagttcc 960 atggtctcttacagcatagcagttatagtatccgttaaaaaaccaacccgatttacggac 1020 atgcaattggaattatgttcaagggttaaagtgttttggaatacaggtgttcctcctaca 1080 aagacgtttaatgaagaattttataatgctgcatcaatgaaatggaatttgaatgatgaa 1140 aacttcgatttgtttgtaccattaagcatatccccagatgatcaaatgattgaaaacaac 1200 tccaacgatcgtcaaatgaggttgttcaagaatattcctacagaggagagactgtatttg 1260 gacaagactaaaacaaaagccagccttttaaacgccatagacgtaaataagactcatctt 1320 taccaacctggagactatgtattcttagtaccagtggttttctctaatcatattccggag 1380 actatctatttaccctctgcacgtgttagttacagactaaggcttgcaacaaaggcaatc 1440 aatagaaagggtttctatcgtcaagattcaaactctccgcaacctattgtgtcgccagac 1500 tcttcttcatcactaagctccactacatcttcattaaaacttaccgaaacagaatccgct 1560 caggcccataggaggataagcaacactttgtttagtaaagttaaaaatcatctacacatg 1620 agctcacatcaactgaaaaatgaagaatcaggagaagaggacattttcgcagagtatcca 1680 ataaaagttattagaactccaccgcccgttgccgtatccactgcgaataaaccaatctat 1740 attaatagggtttggacagattctttgtcatacgagatttcctttgctcagaaatacgtt 1800 tcactaaacagtgaagtcccaatcaagataaaattggcaccgatatgcaaaaacgtttgt 1860 gttaaacgtattcatgtcagtattactgaaagagtcacatttgttagtaaaggttatgaa 1920 tatgagtatgatcaaacagatcccgttgctaaagacccttataatccgtattatttagat 1980 ttcgcctccaagagaagaaaggaaagaagtgtatcattatttgaaatcagaactaaggag 2040 aagggcacgagagctctaagggaggaaattgttgaaaattcattcaatgacaatctctta 2100 tcttatagtccttttgatgacgacagcgattcaaaaggcaatccgaaagaaaggctcggt 2160 ataacggaaccaataattattgaaacaaaattgaagttccccaaatacgaagatttggat 2220 aaaagaaccgcaaagataataccaccttatggtatcgatgcatacacgagcatccccaat 2280 cccgaacatgccgtagccaatggaccctcacaccgtcgtcccagtgtaataggcttttta 2340 tccggtcataaaggctcgaaaagtcatgaagaaaatgaaaaacctgtttatgatccaaaa 2400 ttccatcaaacaataatcaaatccaattctggtttgcccgtgaaaacacataccagatta 2460 aacacaccgaaaagaggcttgtacttggatagtttacacttcagtaatgtttactgtaga 2520 cataagctggaaattatgctacgaatcagtaaacctgatcctgagtgtccgtccaaatta 2580 agacattatgaggttctaatcgatacgcccatattcctggtgtctgaacagtgcaacagt 2640 ggtaatatggagttacccacttatgatatggccacaatggaaggcaaaggcaaccaggtt 2700 cctctaagtatgaacagcgacttttttggtaacacatgtccacctccgccaacttttgaa 2760 gaagccatatccgttccagcttctcccattgtctcaccgatgggatcacctaatatcatg 2820 gcctcgtatgaccctgatttactatctattcaacaattgaacttatcaagaactacgtca 2880 gttagtgggccatccggatacagcgatgatgccggtgtgccaaatgttaatcggaacagt 2940 atttcaaatgccaatgccatgaacggcagtatttcgaattccgcatttgtttcgggcaat 3000 agtggccaaggtgttgctagagcaagagcaacgtcagtgaatgacaggtcaagattcaat 3060 aatctcgataaattattgagcactccatcgcccgtcaatagatctcacaattcatcacca 3120 acaaatggcttatcacaagcaaatggtactgtgaggattccaaacgctaccactgaaaac 3180 tctaaggacaaacagaacgaatttttcaaaaagggttacactttagcgaatgtaaaagat 3240 gatgaagaacaagaaggaatagtaagttcgagctccgcagattcgctactctctcatggt 3300 aacgagcctccgcgttatgacgaaatagtgcctttgatgagtgatgaagaatga 3354 SEQIDNO:34 MPFITSRPVAKNSSHSLSETDLNQSKGQPFQPSPTKKLGSMQQRRRSSTIRHALSSLLGG 60 ANVHSPAVLNNTTKGGNNNGNIRSSNTDAQLLGKKQNKQPPPNARRHSTTAIQGSISDSA 120 TTTPRSSTSDTNRRTSGRLSVDQEPRISGGRYSQIEEDSTVLDFDDDHNSSAVVSSDLSS 180 TSLTRLANSKKFNEQFLIEYLTARGLLGPKTVLSNEYLKISISTSGESVFLPTISSNDDE 240 YLSRLNGLNDGTDDAEADFFMDGIDQQEGNTPSLATTAAATESGGSINENRDTLLRENNS 300 GDHPGSGSELNTRSVEIDSSMVSYSIAVIVSVKKPTRFTDMQLELCSRVKVFWNTGVPPT 360 KTFNEEFYNAASMKWNLNDENFDLFVPLSISPDDQMIENNSNDRQMRLFKNIPTEERLYL 420 DKTKTKASLLNAIDVNKTHLYQPGDYVFLVPVVFSNHIPETIYLPSARVSYRLRLATKAI 480 NRKGFYRQDSNSPQPIVSPDSSSSLSSTTSSLKLTETESAQAHRRISNTLFSKVKNHLHM 540 SSHQLKNEESGEEDIFAEYPIKVIRTPPPVAVSTANKPIYINRVWTDSLSYEISFAQKYV 600 SLNSEVPIKIKLAPICKNVCVKRIHVSITERVTFVSKGYEYEYDQTDPVAKDPYNPYYLD 660 FASKRRKERSVSLFEIRTKEKGTRALREEIVENSFNDNLLSYSPFDDDSDSKGNPKERLG 720 ITEPIIIETKLKFPKYEDLDKRTAKIIPPYGIDAYTSIPNPEHAVANGPSHRRPSVIGFL 780 SGHKGSKSHEENEKPVYDPKFHQTIIKSNSGLPVKTHTRLNTPKRGLYLDSLHFSNVYCR 840 HKLEIMLRISKPDPECPSKLRHYEVLIDTPIFLVSEQCNSGNMELPTYDMATMEGKGNQV 900 PLSMNSDFFGNTCPPPPTFEEAISVPASPIVSPMGSPNIMASYDPDLLSIQQLNLSRTTS 960 VSGPSGYSDDAGVPNVNRNSISNANAMNGSISNSAFVSGNSGQGVARARATSVNDRSRFN 1020 NLDKLLSTPSPVNRSHNSSPTNGLSQANGTVRIPNATTENSKDKQNEFFKKGYTLANVKD 1080 DEEQEGIVSSSSADSLLSHGNEPPRYDEIVPLMSDEE 1117 SEQIDNO:35 atgcccatggaccaatctatctcatctccattgtttcccatggaaaaggatattgatatc 60 cccctcgatgctacacccttggcacaaagttcatcattacagctttttattcatttagct 120 gaaccagttgttttcctccaaggctttgaccctcagaagacggaatatccctcggttgtt 180 cttcggggctgtctagtggtaagaatactgaaacccacaaagctgaaaagcataagtctt 240 tcgttcaaaggatattctagaactgaatggcctgaaggtatccctcctaaaagacaagaa 300 ttcgtggaaatcaaagatattgtagaccatacatgggctctatatccgccaactgaacag 360 aagagcaagaaaaagatggatgcttccgcacctaatgagagcaacaatgcagctaataat 420 tttttgacgaaggaaagtggtgcctctctttatagaacactgtctgataatgaaactata 480 acaagcagaaaaaattctatatcaggtttgtcctcgttgaacttgtcacctctaggtgca 540 cctggaaattcctctgtcaacgtaaaagacagagaaagtagacaaagatctagatcttcg 600 tcagtcacttcttccaatggaccatcaagaaacctatccccgataaatttattgaagaga 660 gccacgtctccttccgtgtctcaccacaactataaacctacgaccacttccatcttttcc 720 gacttgttgaataacacctttacccataatgatgcagcatcgcatcatggtcatcatatc 780 cccaccagtagcaatcatctggcaatgacaagcaacaacttcaccagcgggtctggagga 840 gaattttttgtctttcaaccaggcgactatatttatgctttcgaagaactaattcctcaa 900 gcatacccagaatctattaaagctgatttcggatttgtggaatacttcttatttgccagt 960 atagagagacctggtgcctttaaatcaaacattagcgcccggcaagtggttaatatcgta 1020 cggacacaggctcataattctgtggaagaaagtgagccgattatcatatctagagattgg 1080 gaaaaccaattatattatgatatcgttatagcatcaaaggatattattttagatgctttt 1140 ctgcctatcacgttcaaattcgctcccctcgataaagttacgttgcatagaataagaatt 1200 tatgtgacagagacaatggagtattattgtagagaaaagaaggttcataggatggagccc 1260 accaagaaatttttattgacagaacagaaaggtcctaaattaccgaacttgcccaatgat 1320 gcaaatttgtcaaaggccaagaatatggggaacctgttgcaggatccaaagaatggtgat 1380 ttagtgaataaagagtatgagtaccagatttttattccgagtcgtttcaacaaccatcag 1440 caattgcatccagatacttcttatgaaaacatcaaagcaaaccattggattaaaatttgc 1500 ctgagactgtctagagtagtagataataaaaggaaacattacgaaattagtattgactcg 1560 ccaatacatgttttacatagattgtgctcgcatgcaaatacccttttaccgagctatgat 1620 ggacatcctgcttcttttccaaaagaaacagattcctcaatttcctcaatattggaatcg 1680 tctgatgacaatataaatctataccataactctaatattttctttcccaaggaagtcctt 1740 tcgtctccagtactttcgcccaatgtccaaccattagacattttaatcccacatttacct 1800 tccacttcattgaccagaaactctaggcaattcaataggaactcaaaatcccatccgagt 1860 gataataccatcttcaattctgcaaagttgaaatccaacatatatcaaccggagagtttg 1920 caaagagaattagcatcaccccaggcaatcccgctctctccaataacatcgccaatgtca 1980 aatatggaagtgcctccgccagattttgacttttcttccgatttcatatctgatgctgct 2040 tccggaaccactactactgaggtatcttcatcagagtcgagcatcttaccacgggatcca 2100 ccatcttataaggatactgtgttgcatgacaacaatcaaaaaaggaggcctaattccaaa 2160 catccgacgcctccaagtttaaaagcttcccatccaaataaaaattcggataagaattct 2220 tcagaaactttgaataaaaaagaatcgatgtcaaagatagaagaaaataaacacaaaaga 2280 gagacaactcctaaaaagagagaaaatagggacgtgaaaagtttatcaaccccacaacgc 2340 gaggaaagcaaagactcgacatccactgggaatcaaagtaacgaaaagaacagaaaaaga 2400 gtattaagcctatcgtcttcattacatagctcaccaaataatagcggatttgcgcattca 2460 gctttaggaaatctgagcaatgaatcattaagatcattgaatagaagggaaagtgttcaa 2520 gataatttaccgtccacaataagacacgataatccttttttcacagatttaaatcaagtt 2580 ttaatagaagacgaacttaaaaatcatgataaaaatgaactaaatcgacattctacaaat 2640 acttcgagcacccccgcctcagctagatcctcttttgactattcaggaattaatataagc 2700 aaggacaagttgaacatggaaccattactgagtaaaacggaaacgttgactaataaagtt 2760 aatgaagactcctttttaaggcctaatgattcatacgttgatctacttgaaccctcagta 2820 gatactacgattgatatcactgcgccgtacgctagaaattcctctgcttggcatccttta 2880 caaaacgataacgataacaatcagttttctccacttttgggaagtaacgagaatttcttg 2940 aatgcagctaatgcacaaaattctgccgaatcagatcataataatgacattttcacacag 3000 ggctcaggattaacggaaagctctaagaattctgattccgaggaaagatttatttcaaga 3060 ctttcttcacccgagaaagtactgattaatacgttagataatgaatctggattacaaagt 3120 ataaatgagagtaccctttag 3141 SEQIDNO:36 MPMDQSISSPLFPMEKDIDIPLDATPLAQSSSLQLFIHLAEPVVFLQGFDPQKTEYPSVV 60 LRGCLVVRILKPTKLKSISLSFKGYSRTEWPEGIPPKRQEFVEIKDIVDHTWALYPPTEQ 120 KSKKKMDASAPNESNNAANNFLTKESGASLYRTLSDNETITSRKNSISGLSSLNLSPLGA 180 PGNSSVNVKDRESRQRSRSSSVTSSNGPSRNLSPINLLKRATSPSVSHHNYKPTTTSIFS 240 DLLNNTFTHNDAASHHGHHIPTSSNHLAMTSNNFTSGSGGEFFVFQPGDYIYAFEELIPQ 300 AYPESIKADFGFVEYFLFASIERPGAFKSNISARQVVNIVRTQAHNSVEESEPIIISRDW 360 ENQLYYDIVIASKDIILDAFLPITFKFAPLDKVTLHRIRIYVTETMEYYCREKKVHRMEP 420 TKKFLLTEQKGPKLPNLPNDANLSKAKNMGNLLQDPKNGDLVNKEYEYQIFIPSRFNNHQ 480 QLHPDTSYENIKANHWIKICLRLSRVVDNKRKHYEISIDSPIHVLHRLCSHANTLLPSYD 540 GHPASFPKETDSSISSILESSDDNINLYHNSNIFFPKEVLSSPVLSPNVQPLDILIPHLP 600 STSLTRNSRQFNRNSKSHPSDNTIFNSAKLKSNIYQPESLQRELASPQAIPLSPITSPMS 660 NMEVPPPDFDFSSDFISDAASGTTTTEVSSSESSILPRDPPSYKDTVLHDNNQKRRPNSK 720 HPTPPSLKASHPNKNSDKNSSETLNKKESMSKIEENKHKRETTPKKRENRDVKSLSTPQR 780 EESKDSTSTGNQSNEKNRKRVLSLSSSLHSSPNNSGFAHSALGNLSNESLRSLNRRESVQ 840 DNLPSTIRHDNPFFTDLNQVLIEDELKNHDKNELNRHSTNTSSTPASARSSFDYSGINIS 900 KDKLNMEPLLSKTETLTNKVNEDSFLRPNDSYVDLLEPSVDTTIDITAPYARNSSAWHPL 960 QNDNDNNQFSPLLGSNENFLNAANAQNSAESDHNNDIFTQGSGLTESSKNSDSEERFISR 1020 LSSPEKVLINTLDNESGLQSINESTL 1046 SEQIDNO:37 atgttttcatcatcatctcgaccttcaaaagagccattactatttgacatcagacttaga 60 aatttggacaatgatgttttactgataaaaggcccccctgatgaggcatcttctgtccta 120 ctatctggaactatagtattgtcaattactgagccaattcaaatcaagtctttggctttg 180 agactttttggtaggttgagactaaatattccaacggttttacaaactgttcatgggccg 240 cataagcgatactcaaagtttgagagaaacatatattctcatttttgggatgattttaat 300 ataaaaagttatttccaaaacttgtacgataatcataataatggtaaaataacaatttct 360 agtaaatcctcaacaaatttagcagcattgccaaagagaaaaagagccctttctactgca 420 tcattgatatcaagtaatgggcagacaagcgcaagcaaaaactatcacaccttagtaaaa 480 ggtaactacgaattccctttcagcgcgattattcctgggtcattagtggaaagtgtagaa 540 ggcctaccaaatgctgccgtcacttatgctctggaagctactatcgagagacctaagcag 600 cccgacttgatctgtaaaaaacatctaagagttattcgaacgttagctatagatgcagtc 660 gagttatctgaaacagtatcagtggataactcatggcctgaaaaagtcgattatacgatc 720 tccattccaactaaggcaattgccattggctcttccaccatgatcaatattttaattgtt 780 cctatattaaaaggattgaagttaggccctgttaggatcagtttggtggaaaattcccag 840 tattgtggtagctatggaggggttatcaaccaagaaagaatggtggctaaattaaaacta 900 aaagatcccctgaagcacgttgcccaaataaagaagaagaggagcctaaatgaagctgcc 960 gacgaaggggttgatacggacacaggggaatttcaagataaatgggaagttcgagcttta 1020 ttaaacatacctgcaagcctgactaaatgctcccaagactgtcgcattttatctaatatc 1080 aaagtccgtcataagatcaagttcactataagtttactcaatccggacggtcatatttca 1140 gaattgcgtgcggcactgcctgtccaattattcatttcaccgtttgttccagtcaatgta 1200 aagacctccgatgttattgaaagaacgctcaaaacgtttggaccctcatatcaagtaaca 1260 agtcagcacgataattcattcagcagcaaaaactttgtagacgatagtgaagaagatgtg 1320 atttttcaaagatctgcttctgcgttacaattgtcttcaatgccaaccatagtatctggc 1380 tctactttaaatatcaatagtactgatgcagaggctaccgcagtcgctgacacaactatg 1440 gtaactagtttgatggtacctcccaactacggcaatcacgtttacgatcgagtgtatggc 1500 gaggtaactaatgaagacgaaacttcagcatcagcttcttcaagtgccgtcgaatcacag 1560 gcaattcacaatattcaaaacctatatatatcggatagtaacaatagcaataatcctatt 1620 ttggcaccaaatcctcaaatcaagattgaagatgatagcctaaataattgtgactctcga 1680 ggggacagcgttaacaatagtaacctgaatctggttaatagtaatctaacaattagtgaa 1740 aattggaacaataactctccttctgcaaatagatataataacatcattaatgctggattg 1800 aatagtccttcactgacaccaagctttgcacatttatctaggcgtaactcatatagtcgc 1860 caaacatcttctacatcgctgaagaacgatttggaactgacagatttaagcagagttccc 1920 tcgtatgataaagcaatgaaatctgatatgattggtgaggatcttccaccggcttatccc 1980 gaggaagaacttggagttcaagaaaataaaaaaattgaactagaaaggccacaaattctt 2040 catcacaagtctacatcctctttgttgccacttccaggctcgagcaagagttccaataat 2100 ctgaaaagatcgtctagtaggacacatttatcccactctccattaccaaggaataatagc 2160 ggatcctcagtatcattgcagcagttggcgagaaacaacacagatagttcatttaatcta 2220 aatctctctttcacttcagcaaaaagcagcacaggaagcagacattttccgtttaatatg 2280 acaacatctttcactagtaattcaagttccaagaacaattcacattttgataaaactgat 2340 tctacatctgacgctaataagccaagagaagaggaaaactatacgagcgcaacccacaat 2400 cgaaggtcacgctcatcgtcagttcggagcaacaatagcaactcaccattaagacaagga 2460 acaggttcatttgctaatttaatggagatgttcacaaaacgggatcgctcatag 2514 SEQIDNO:38 MFSSSSRPSKEPLLFDIRLRNLDNDVLLIKGPPDEASSVLLSGTIVLSITEPIQIKSLAL 60 RLFGRLRLNIPTVLQTVHGPHKRYSKFERNIYSHFWDDFNIKSYFQNLYDNHNNGKITIS 120 SKSSTNLAALPKRKRALSTASLISSNGQTSASKNYHTLVKGNYEFPFSAIIPGSLVESVE 180 GLPNAAVTYALEATIERPKQPDLICKKHLRVIRTLAIDAVELSETVSVDNSWPEKVDYTI 240 SIPTKAIAIGSSTMINILIVPILKGLKLGPVRISLVENSQYCGSYGGVINQERMVAKLKL 300 KDPLKHVAQIKKKRSLNEAADEGVDTDTGEFQDKWEVRALLNIPASLTKCSQDCRILSNI 360 KVRHKIKFTISLLNPDGHISELRAALPVQLFISPFVPVNVKTSDVIERTLKTFGPSYQVT 420 SQHDNSFSSKNFVDDSEEDVIFQRSASALQLSSMPTIVSGSTLNINSTDAEATAVADTTM 480 VTSLMVPPNYGNHVYDRVYGEVTNEDETSASASSSAVESQAIHNIQNLYISDSNNSNNPI 540 LAPNPQIKIEDDSLNNCDSRGDSVNNSNLNLVNSNLTISENWNNNSPSANRYNNIINAGL 600 NSPSLTPSFAHLSRRNSYSRQTSSTSLKNDLELTDLSRVPSYDKAMKSDMIGEDLPPAYP 660 EEELGVQENKKIELERPQILHHKSTSSLLPLPGSSKSSNNLKRSSSRTHLSHSPLPRNNS 720 GSSVSLQQLARNNTDSSFNLNLSFTSAKSSTGSRHFPFNMTTSFTSNSSSKNNSHFDKTD 780 STSDANKPREEENYTSATHNRRSRSSSVRSNNSNSPLRQGTGSFANLMEMFTKRDRS 837 SEQIDNO:39 atgctccaattcaatacagaaaatgatactgtagctccagtgtttcccatggagcaagat 60 ataaatgcagcacctgatgccgtcccactggtgcagacaacaacactacaagtctttgta 120 aagcttgccgaacccatagtgtttttaaaaggatttgaaactaacggactgtctgaaata 180 gcccccagtatcttacgaggatctcttatcgtcagggtgttgaaaccgaataaattaaaa 240 agtatatcgataaccttcaaaggaatatccagaacagagtggccggaaggtataccaccg 300 aagagagaagaattttcagatgttgaaactgttgtcaatcacacatggccattttatcag 360 gcggatgacggcatgaattctttcaccttagaacatcacagctcaaataattcgtccaat 420 cgcccatctatgagcgatgaagattatctacttgaaaaaagcggtgcttcagtatatatc 480 ccaccaaccgctgaaccccctaaagataatagcaatctaagtctggatgcctatgagcgc 540 aactcattgtcatccgataatttgagtaacaagccagtatcaagtgatgtttcccatgac 600 gacagtaaactgttggctattcaaaagacaccattaccatcatctagtcgaagaggatcg 660 gtaccggcaaattttcacggtaactctttgtcacctcataccttcatatctgatttgttt 720 acaaaaacattcagtaatagtggcgctactccaagtcctgagcaagaggataactatctt 780 acaccatccaaagattctaaagaagtttttatttttcgaccgggcgattatatttacact 840 tttgaacagccaatatcgcaatcttatccagaaagtataaaagccaattttggttccgtg 900 gagtataaactgtcaatagacatagagaggtttggcgcattcaaatcaactatacatact 960 caattacccatcaaagtcgtaaggcttccttctgatggatccgtagaagagactgaagct 1020 attgcaatttccaaggactggaaagatcttcttcattatgacgtggtaattttctcgaaa 1080 gagatcgttttgaatgcatttttacccatcgatttccatttcgctcctctagataaagtt 1140 actctgcatcgtattagaatttatctaacagagtctatggaatacacttgtaatagtaat 1200 ggaaatcacgagaaggctcgtagattagagccaactaaaaagtttctgttggctgaacat 1260 aacggtcctaaactgcctcatataccagctggttcgaatcctttgaaggctaaaaataga 1320 gggaacatcctcttggatgaaaaatccggcgatctagttaacaaagattttcagttcgag 1380 gtgtttgtcccaagcaagtttacaaacagtatacggttacaccctgatacaaattatgat 1440 aaaatcaaagcccaccattggataaaaatttgccttcgtctttccaagaagtacggggac 1500 aatagaaaacatttcgaaataagtattgattctccaatccatattttaaatcaactatgc 1560 tcacacgcgaatactttgctaccgagctacgagagtcatttccagtattgtgatgaagat 1620 ggtaatttcgcaccagcagcagatcaacaaaattacgcaagtcatcatgattccaatatt 1680 ttcttcccaaaagaagttctttcgtctcccgttctttcacctaacgtgcagaagatgaac 1740 attagaataccgtctgatcttccagtagtgcgtaatagagctgaaagcgtaaagaaaagc 1800 aagtcagataatacctccaagaagaatgatcaaagtagcaatgtcttcgcatccaaacag 1860 ctggtcgcaaacatttataagcccaatcagattccaagagaattaacttctcctcaggcg 1920 ttaccattatcgcccatcacctcaccaattctcaattaccaaccattatcaaactccccg 1980 cctccagattttgattttgatctagctaagcgcggcgcagccgattctcatgctattcct 2040 gtggatcctccatcatattttgatgtattaaaggccgatgggattgaattgccatactac 2100 gatacaagttcatctaaaattcctgaactaaaactaaacaaatctagagagacattggcc 2160 agcattgaggaggactcattcaatggttggtctcaaattgatgacttatccgacgaagat 2220 gacaatgatggcgatatagcatctggtttcaacttcaagctgtcaaccagtgctccgagt 2280 gagaacgttaattcacacactcctattttgcagtctttaaacatgagtcttgatgggaga 2340 aaaaaaaatcgtgccagtctacacgcaacatcagtgttacctagtacaataagacagaac 2400 aatcagcatttcaatgacataaaccagatgctaggcagtagtgacgaagatgcctttccc 2460 aaaagccaatcattaaatttcaataagaaactaccaatacttaaaattaatgataacgtc 2520 atacaatcaaacagcaatagtaataacagagttgataatccagaagatacagtggattct 2580 tcagtcgatattacagcattttatgatccaagaatgtcatcagattccaaatttgattgg 2640 gaggtaagcaagaaccatgttgacccagcagcctactcggttaacgttgctagtgaaaac 2700 cgtgtactggacgactttaagaaagcatttcgcgaaaagagaaaataa 2748 SEQIDNO:40 MLQFNTENDTVAPVFPMEQDINAAPDAVPLVQTTTLQVFVKLAEPIVFLKGFETNGLSEI 60 APSILRGSLIVRVLKPNKLKSISITFKGISRTEWPEGIPPKREEFSDVETVVNHTWPFYQ 120 ADDGMNSFTLEHHSSNNSSNRPSMSDEDYLLEKSGASVYIPPTAEPPKDNSNLSLDAYER 180 NSLSSDNLSNKPVSSDVSHDDSKLLAIQKTPLPSSSRRGSVPANFHGNSLSPHTFISDLF 240 TKTFSNSGATPSPEQEDNYLTPSKDSKEVFIFRPGDYIYTFEQPISQSYPESIKANFGSV 300 EYKLSIDIERFGAFKSTIHTQLPIKVVRLPSDGSVEETEAIAISKDWKDLLHYDVVIFSK 360 EIVLNAFLPIDFHFAPLDKVTLHRIRIYLTESMEYTCNSNGNHEKARRLEPTKKFLLAEH 420 NGPKLPHIPAGSNPLKAKNRGNILLDEKSGDLVNKDFQFEVFVPSKFTNSIRLHPDTNYD 480 KIKAHHWIKICLRLSKKYGDNRKHFEISIDSPIHILNQLCSHANTLLPSYESHFQYCDED 540 GNFAPAADQQNYASHHDSNIFFPKEVLSSPVLSPNVQKMNIRIPSDLPVVRNRAESVKKS 600 KSDNTSKKNDQSSNVFASKQLVANIYKPNQIPRELTSPQALPLSPITSPILNYQPLSNSP 660 PPDFDFDLAKRGAADSHAIPVDPPSYFDVLKADGIELPYYDTSSSKIPELKLNKSRETLA 720 SIEEDSFNGWSQIDDLSDEDDNDGDIASGFNFKLSTSAPSENVNSHTPILQSLNMSLDGR 780 KKNRASLHATSVLPSTIRQNNQHFNDINQMLGSSDEDAFPKSQSLNFNKKLPILKINDNV 840 IQSNSNSNNRVDNPEDTVDSSVDITAFYDPRMSSDSKFDWEVSKNHVDPAAYSVNVASEN 900 RVLDDFKKAFREKRK 915 SEQIDNO:41 atgggcttcagtagcggtaaatcaactaagaaaaagcctctgcttttcgatatcagactt 60 aaaaatgttgacaacgatgtaatactcctcaaaggtcctccaaacgaggccccctcggtg 120 cttttatctggttgcatcgttttatcgattaacgaacccatgcagatcaaaagcatatca 180 ttgagactttatgggaagatacaaatagacgtaccattagagaggccccaggacgctagt 240 tcttcgtcgttgtcttcatcgccgccaaagatcagaaagtacaacaaagttttttataat 300 tacgcatgggataatgttaacctcaaggagtatctgagtggtttaagagggcaatctggc 360 cttgcgggcagtagctcatcaagtaatatcttgggcactcgccaaagagctcagtccaca 420 agttccttgaagtctttaaaggggtcctcctcaccctcttcatgtactttagataagggc 480 aactacgattttccctttagtgctattttgcctggttcgttaccagagagcgtagaatct 540 ttgccaaattgcttcgtgacatatagcatggaatccgttattgaacgcagcaaaaattat 600 agtgatttgatctgtaggaaaaatattagagttctgagaaccatttcacccgcagcagtg 660 gagttatcagaaactgtttgtgtagataactcatggcccgacaaagtggattattctatt 720 tcagtacccaacaaagccgtagctattggttcagccacccctataaatatttccattgta 780 cctctttcgaaaggtttgaaattgggctcaatcaaagtcgtattatttgagaattatcaa 840 tattgtgaccccttccctccagtaatttctgaaaataggcaagtgacagaactaaatctt 900 gaagatcccttgaacgagtcatctggagaatttaatggtaatggttgctttgtaaataac 960 cccttttttcagcctgatcattcattccaagacaagtgggagattgataccatcctgcaa 1020 atcccgaacagcttatcaaactgtgtgcaagattgtgatgtccgctctaacattaaggtt 1080 cgccataagctcaaatttttcatcatcctaattaacccagatggtcataaatctgagtta 1140 agagcgtccttaccgattcaactttttatttcaccatttgtggcactttcaataaaacca 1200 ttgtcatcctcgaatttgtattcgctttttagcaccactaaccagaaagacgaaaactca 1260 tcacaagaagaggaagaggaatatctgttttctagatcagcatcagtcacagggttggaa 1320 ttattagcggatatgcgtagcggtggctctgttcctaccatttcagacttgatgacgccc 1380 ccaaattatgaaatgcacgtatatgatcgtctttatagcggttctttcactcgcacggct 1440 gtggaaacgtctggaacatgtactcctttgggaagcgaatgttcgactgtcgaggatcag 1500 caacaggatttagaagatttacgtatacggttgacaaaaattagaaatcaacgtgacaat 1560 ctagggctaccaccgtctgcctcgtctgctgccgcttccagatcgctatctccattacta 1620 aacgttccagcaccagaggatggcacggagagaatcttacctcagagtgctcttggtccc 1680 aatagtggctctgtgccaggagtacatagtaacgtatcacctgttttactttcaagatcc 1740 ccagccccaagcgtgtcagcccatgaagtgttaccagtgccctcgggcttaaattatcca 1800 gagactcaaaacctgaacaaggttccatcgtatggcaaggcaatgaaatatgatatcatt 1860 ggtgaggaccttcctccttcctacccttgtgcgatacaaaatgtgcaaccaagaaaaccc 1920 agtagggtacattccaggaactcttcgacaacattgtcatcttctataccaactagcttt 1980 cattcctctagttttatgagtagcactgcttcccctatttccataattaatggctctaga 2040 agtagttctagtggggtatctcttaatacacttaatgagttaacttcgaaaacttcgaat 2100 aacccatccagtaatagtatgaaaaggtcaccaacaagacggagggctacttctttagct 2160 gggtttatgggaggttttctatcaaagggtaacaaacgatag 2202 SEQIDNO:42 MGFSSGKSTKKKPLLFDIRLKNVDNDVILLKGPPNEAPSVLLSGCIVLSINEPMQIKSIS 60 LRLYGKIQIDVPLERPQDASSSSLSSSPPKIRKYNKVFYNYAWDNVNLKEYLSGLRGQSG 120 LAGSSSSSNILGTRQRAQSTSSLKSLKGSSSPSSCTLDKGNYDFPFSAILPGSLPESVES 180 LPNCFVTYSMESVIERSKNYSDLICRKNIRVLRTISPAAVELSETVCVDNSWPDKVDYSI 240 SVPNKAVAIGSATPINISIVPLSKGLKLGSIKVVLFENYQYCDPFPPVISENRQVTELNL 300 EDPLNESSGEFNGNGCFVNNPFFQPDHSFQDKWEIDTILQIPNSLSNCVQDCDVRSNIKV 360 RHKLKFFIILINPDGHKSELRASLPIQLFISPFVALSIKPLSSSNLYSLFSTTNQKDENS 420 SQEEEEEYLFSRSASVTGLELLADMRSGGSVPTISDLMTPPNYEMHVYDRLYSGSFTRTA 480 VETSGTCTPLGSECSTVEDQQQDLEDLRIRLTKIRNQRDNLGLPPSASSAAASRSLSPLL 540 NVPAPEDGTERILPQSALGPNSGSVPGVHSNVSPVLLSRSPAPSVSAHEVLPVPSGLNYP 600 ETQNLNKVPSYGKAMKYDIIGEDLPPSYPCAIQNVQPRKPSRVHSRNSSTTLSSSIPTSF 660 HSSSFMSSTASPISIINGSRSSSSGVSLNTLNELTSKTSNNPSSNSMKRSPTRRRATSLA 720 GFMGGFLSKGNKR 733 SEQIDNO:43 atgcaatctactgtcccaatagcaattgcgagcaacggcaacaagagagatgtcgtccag 60 aacgtttctgcaggcgacgagggtgatatattgcaaaggctagcccgtaacagagagatg 120 atttctacctccctctcgccacaaaaatcgtcaggatttagtggtagaaggaggtcatct 180 agtgttagggacgccctttcttctttttttggaactggtaatagtccaacatctagtatg 240 gacgattattccaatttgatgaaccgtaactattctaccgcatcaactgccatgtgtagg 300 gggaacagttttccttcagatgttggcactaaggcttacaatattacgggatcttaccaa 360 ccggataggcacaggaattctgttccgtataccaccatagaccagttacacacaaggcaa 420 gacaccgggttgaggagagagtcagatccagtcgcggcaaaacaaatatctagtaataat 480 gatattgttaggtcattcataacacatcatgctagtaatagcactatgtttattaatagg 540 gtgctatcggactatttagcggatcgtggtttcatcaagcaaacaccgttatataataag 600 aaaagtgtgctggaaatttccattgcaacaagtgcagaatcagttttcttgccaactaca 660 aaaagtgatgaaacagagtatctatcactgattcatggttctttaaatcaggcgcgaaca 720 cagcctgtcgggtccactaacactgcagaaagtgatttcctcccttcatgtcctacgatg 780 gacactttgaatgaaaacaatgatttatcactatttccgttacatacacagcgaaccagc 840 ccctctaatacagcaaggacaggtaatgctatggatacaagcaattctgatcgtgcttct 900 ccggcctcgaacaataacacaacagatgcggattcctttgttgcgagtggcaataacaac 960 cctatgaataataacaattctcccgcgagaaacagacatcctaattctcactcgcgttct 1020 cttcctaatgcttggaatagccaaatgccttcattcagctttgcattgatattttccctg 1080 aataaatcaactaccctttctgatattaaagtagaactcacttctaacgtgagagtggtg 1140 tggttcaatggtcttccccctaccaagaatgttaacgaggaatgctataatataggttct 1200 ttggactggaccttaaatgcagacaactttaatcttttcattccgcaaggcgcaaagtct 1260 cctcttgatatcgttgaaaatcattccaataacaggaaattgaaagtgctccagaaatta 1320 tcgatgaggaaacgccgttctttctcgaataaagcagttcttagggaaaatatattaaac 1380 aatttaaatgcctcgaattctacgaacaagttaaatgctggtgtttatgtctttactatc 1440 cccatagtgcttgccagtcgtattcctgaatcgctttactacccatcagcgagggtatcc 1500 tacagcttaagattagcgacaaaattgaaggatgaacatacacagttggttgcatcacgg 1560 ccacgttcttcttctatctcttctcctcaaaaactgcgttcatattcctgttctgattct 1620 tatgaatattctcaaattgatgacaccatagaaggagaaacctacaataacgacaaaaat 1680 tctactggaaaaatcgcatttccctcctcatggttaaaaagtgcgaaggggcgcttaaaa 1740 aggaataattctaacggaaggtcagataataatggcgcatcttctagtggtttagcgatg 1800 caacatgattctgaagacactataaatttacagtacccgcttaatttggtgagaactccg 1860 ccagaaatctctgtcactacagcaaataagccactttacattaacaaggtttgggagaat 1920 tgtctttcttatgaaatttcattcgcccaaaagtatgtgcccttgaatggtgaaattcca 1980 atcacaattaaagtggcacctctagtaaaaagtcttagtgtcaagagaattcgtgttagt 2040 tgtagagaaaaaatctcctacaggagtaaagactatcaatatgattttgaccagttggat 2100 ccattggcttcagatccttgcaatccctatcatatgagatatttagtgagaaaaaagaag 2160 gacagaagcttgcctctatttgaggtggcctctaaatgtactagtgggccttctattaga 2220 gaggaagttgtcaccaatacagttgatgataacttattagcctacacttcatcaaaagaa 2280 aacaacaaagatatcccattttctgagtcctttactgttaaaacgaagttaaaatttcca 2340 aaatattgtgaagtggacgctaccaaagctgcaagtctaccaccatatggtatcgatctt 2400 ttcgacccaataaaagatccaactcagagtgagaacacctctaataacggcaatgtattg 2460 ggctttctagtgggtcgccctaacagggcttccaagacagttcataaaataccgcaagac 2520 aagaatcataatgaggtcaatgatacaaatggaaactcgaatacatctttgcaaactagc 2580 tcgaatgttcccattcagcactacacacggttgaataaaccaagacgcggtttatatttg 2640 gacagtatgcattttaagaatatccaatgttctcataaattagaaatcgtcttgagggtt 2700 agcaaaactgatagtggtagctcaaaaatcataaggcattatgaagtaattgttgataca 2760 ccaatttatttgatttctgacctttgtaacacttcaaatatagacttaccgacttatgac 2820 atggccaccactgaatcttctaaagtcctgccaccaacttttgaagaggcaacatcagtt 2880 tcagcatcaccaagatcttctgtatcttattatcccgatgacatttccatgcaacagttg 2940 aatttgtctaggtcgacttccctcgcaaatggttacctgtcaaccttacatccaaaaaca 3000 accgctgtttcggactcgtctaacggtgccccaatccgggaccagcaagagcaacaagca 3060 cgccccttgaggactgaagattatgcgctacaaatggggaatgaaaataacgcctatagc 3120 aatatggacggtttgctttcgcaggatatctttgaacaggagaccgcggccacgctattt 3180 aaaagagacattgtcacaatgaactttaacaataatatattcacaccacggtatagtccg 3240 cgcacttttaccaataccgactacaattataatgataatgataataatgataatgataca 3300 gaggggcctggtccaataattcatccgggtcctgaaccaccaagatatgacgagatttca 3360 tcataa 3366 SEQIDNO:44 MQSTVPIAIASNGNKRDVVQNVSAGDEGDILQRLARNREMISTSLSPQKSSGFSGRRRSS 60 SVRDALSSFFGTGNSPTSSMDDYSNLMNRNYSTASTAMCRGNSFPSDVGTKAYNITGSYQ 120 PDRHRNSVPYTTIDQLHTRQDTGLRRESDPVAAKQISSNNDIVRSFITHHASNSTMFINR 180 VLSDYLADRGFIKQTPLYNKKSVLEISIATSAESVFLPTTKSDETEYLSLIHGSLNQART 240 QPVGSTNTAESDFLPSCPTMDTLNENNDLSLFPLHTQRTSPSNTARTGNAMDTSNSDRAS 300 PASNNNTTDADSFVASGNNNPMNNNNSPARNRHPNSHSRSLPNAWNSQMPSFSFALIFSL 360 NKSTTLSDIKVELTSNVRVVWFNGLPPTKNVNEECYNIGSLDWTLNADNFNLFIPQGAKS 420 PLDIVENHSNNRKLKVLQKLSMRKRRSFSNKAVLRENILNNLNASNSTNKLNAGVYVFTI 480 PIVLASRIPESLYYPSARVSYSLRLATKLKDEHTQLVASRPRSSSISSPQKLRSYSCSDS 540 YEYSQIDDTIEGETYNNDKNSTGKIAFPSSWLKSAKGRLKRNNSNGRSDNNGASSSGLAM 600 QHDSEDTINLQYPLNLVRTPPEISVTTANKPLYINKVWENCLSYEISFAQKYVPLNGEIP 660 ITIKVAPLVKSLSVKRIRVSCREKISYRSKDYQYDFDQLDPLASDPCNPYHMRYLVRKKK 720 DRSLPLFEVASKCTSGPSIREEVVTNTVDDNLLAYTSSKENNKDIPFSESFTVKTKLKFP 780 KYCEVDATKAASLPPYGIDLFDPIKDPTQSENTSNNGNVLGFLVGRPNRASKTVHKIPQD 840 KNHNEVNDTNGNSNTSLQTSSNVPIQHYTRLNKPRRGLYLDSMHFKNIQCSHKLEIVLRV 900 SKTDSGSSKIIRHYEVIVDTPIYLISDLCNTSNIDLPTYDMATTESSKVLPPTFEEATSV 960 SASPRSSVSYYPDDISMQQLNLSRSTSLANGYLSTLHPKTTAVSDSSNGAPIRDQQEQQA 1020 RPLRTEDYALQMGNENNAYSNMDGLLSQDIFEQETAATLFKRDIVTMNFNNNIFTPRYSP 1080 RTFTNTDYNYNDNDNNDNDTEGPGPIIHPGPEPPRYDEISS 1121 SEQIDNO:45 atggccaaagatttgaacgattcggggtttccaccgaagaggaagcctttgctgcgtcct 60 caacgatctgattttaccgcaaatagttcgacaactatgaacgttaatgcaaacacaagg 120 gggcgtggtaggcagaaacaagagggtggtaaaggcagttcgaggtcaccgtcgttacac 180 tctccaaaatcatggataagaagcgcgtctgctacggggatccttggactaagacgtccc 240 gaactagcacattctcattcgcatgctccttccaccggaacgcctgctggaggtaatcgt 300 tctcctttgagaagatcaactgcaaatgcgacccccgtcgagaccggaaggtccttgacc 360 gacggagatatcaacaatgttgttgatgtactgccctcatttgagatgtacaataccctg 420 cataggcacattccgcagggcaacgtcgatccagataggcatgatttcccaccttcatac 480 caagaggccaataattctactgcaacaggtgctgcgggctcgagcgctgatctctcacat 540 caatcattgtccactgacgcattgggtgccacacgttcttcgtcaacatcaaatttagaa 600 aacttaattccccttcgaaccgaacatcacagtattgcagcacatcaatcaaccgctgtc 660 gatgaagattcactggatatacctcccatacttgatgacttgaacgatacagacaacatt 720 ttcatcgacaaattgtacactttaccaaaaatgtccacacccatcgaaatcaccatcaag 780 acgacgaagcatgcacctataccacacgtgaagccggaggaggagtccattttgaaagag 840 tatacgtcgggggatttgattcatggttttatcactattgaaaacaaatctcaagcaaac 900 ctaaagtttgaaatgttctatgtcactttagagtcttacatttccattattgataaagta 960 aagagtaaaagaacgattaaacggtttttaaggatggtagacttgagcgcttcttggtca 1020 tactcgaaaatagcactggggtccggtgtggacttcattcccgcagatgttgactacgat 1080 ggttctgtatttgggctaaacaatagccgggttctggaacccggagtcaagtacaagaaa 1140 ttcttcattttcaaattgccactgcaattgctagatgtcacttgtaagcaggagcatttc 1200 tctcattgtttgttacctcccagttttggtattgataaatataggaacaattgcaaatat 1260 tccggtatcaaagtcaatagggtacttgggtgcggtcatttaggtacaaagggctccccc 1320 atcttaactaacgatatgtctgatgacaacctttcgatcaattacactattgatgcaagg 1380 attgtcggtaaagatcaaaaggcctctaaactgtatattatgaaggaaagagaatataat 1440 ctaagagtaatcccttttggttttgacgccaatgtcgtcggagaaagaaccactatgagt 1500 cagctgaatgatatcaccaaactagtgcaggaaaggttggatgctcttagaaaaatcttt 1560 cagagattagagaaaaaagaacccataacgaaccgcgacattcacggtgcagacttgagt 1620 ggtaccattgatgattctattgaatcagactcccaagaaattttgcagaggaaattggac 1680 caactgcacattaagaacagaaataactatttagtcaactataacgatttgaagttgggc 1740 cacgatttggacaatggccgcagtggaaatagtggtcataataccgatacttccagagct 1800 tggggtccctttgttgaaagtgaactaaaatataaactgaaaaacaaatccaattcctcc 1860 tcatttctgaacttctctcattttttaaacagcagttccagctcaatgtcctcttcctca 1920 aatgcgggaaagaataatcatgatttaacgggaaataaagaaaggacagggctaatacta 1980 gtaaaggcgaaaattccaaaacagggcctaccatattgggctccctcattattgagaaag 2040 accaatgtttttgaatctaagagtaaacacgaccaagaaaattgggtgagattgtctgag 2100 ttgattccggaagacgtaaaaaaaccattggaaaaacttgatttacaattgacttgcata 2160 gaatccgataatagcttacctcatgatccgccagaaattcaatcgattaccacagaactg 2220 atatgtataactgctaaatctgataattctatcccaataaaactcaattctgaactgttg 2280 atgaacaaagagaagctgacaagcatcaaagctttgtacgatgatttccattcaaaaatt 2340 tgtgaatatgaaaccaagttcaacaagaattttcttgaattaaatgagttatataatatg 2400 aataggggagaccgtaggccaaaggaactgaaatttacagattttattacttcacagctg 2460 tttaacgatatcgaaagcatttgcaacttgaaagttagtgttcacaacttatccaacatt 2520 tttaaaaaacaggtcagtaccctaaaacaacactcaaagcacgcattatctgaggattca 2580 atatcgcacacaggtaacggtagttcatcgtcgcccagttcagcgtcattaacgccagta 2640 acttcttcatccaagagtagtttatttttacctagcggtagctcgtctacttccctgaaa 2700 tttacagaccagattgttcataaatgggttaggattgctcctttacagtacaaacgagac 2760 attaatgtgaacttggaatttaataaggacattaaggaaactttaattccaagttttgaa 2820 agctgcctatgttgtaggttttattgcgttcgagtaatgattaaatttgaaaaccatctt 2880 ggcgtagcgaagattgatatccctatttctgttaggcaagtgacaaaataa 2931 SEQIDNO:46 MAKDLNDSGFPPKRKPLLRPQRSDFTANSSTTMNVNANTRGRGRQKQEGGKGSSRSPSLH 60 SPKSWIRSASATGILGLRRPELAHSHSHAPSTGTPAGGNRSPLRRSTANATPVETGRSLT 120 DGDINNVVDVLPSFEMYNTLHRHIPQGNVDPDRHDFPPSYQEANNSTATGAAGSSADLSH 180 QSLSTDALGATRSSSTSNLENLIPLRTEHHSIAAHQSTAVDEDSLDIPPILDDLNDTDNI 240 FIDKLYTLPKMSTPIEITIKTTKHAPIPHVKPEEESILKEYTSGDLIHGFITIENKSQAN 300 LKFEMFYVTLESYISIIDKVKSKRTIKRFLRMVDLSASWSYSKIALGSGVDFIPADVDYD 360 GSVFGLNNSRVLEPGVKYKKFFIFKLPLQLLDVTCKQEHFSHCLLPPSFGIDKYRNNCKY 420 SGIKVNRVLGCGHLGTKGSPILTNDMSDDNLSINYTIDARIVGKDQKASKLYIMKEREYN 480 LRVIPFGFDANVVGERTTMSQLNDITKLVQERLDALRKIFQRLEKKEPITNRDIHGADLS 540 GTIDDSIESDSQEILQRKLDQLHIKNRNNYLVNYNDLKLGHDLDNGRSGNSGHNTDTSRA 600 WGPFVESELKYKLKNKSNSSSFLNFSHFLNSSSSSMSSSSNAGKNNHDLTGNKERTGLIL 660 VKAKIPKQGLPYWAPSLLRKTNVFESKSKHDQENWVRLSELIPEDVKKPLEKLDLQLTCI 720 ESDNSLPHDPPEIQSITTELICITAKSDNSIPIKLNSELLMNKEKLTSIKALYDDFHSKI 780 CEYETKFNKNFLELNELYNMNRGDRRPKELKFTDFITSQLFNDIESICNLKVSVHNLSNI 840 FKKQVSTLKQHSKHALSEDSISHTGNGSSSSPSSASLTPVTSSSKSSLFLPSGSSSTSLK 900 FTDQIVHKWVRIAPLQYKRDINVNLEFNKDIKETLIPSFESCLCCRFYCVRVMIKFENHL 960 GVAKIDIPISVRQVTK 976 SEQIDNO:47 atgacttttacattctccacttcatcaaggaaaaatgggagacctcctttaaaatcagtt 60 tctacggaagataacattcatctattgaggaagcggcgtcaacagcagctgtcaagtaat 120 tctacagataattcgctgcatccaaatagtgggcagactccacgtgcaagtgacagccag 180 gacgatgacatacgcagcgcttcaacaaccaatttagaccgtttacgacaagaacgagag 240 gaaaattcactggaaatggactgcacacagtcaagattatctcatagagcaaatatgcta 300 gtggatgtcctaccatcttttgagatgtataatgccttgcacagacacatacctcaagga 360 aacgttgatcccgatagacatgatttccccccttcttatcaagaagttcgcactcaaaga 420 atgactatattgcccagcaatgataattccgtggaaaggtcacaattgacagcagtgcca 480 ggatccgaaaacgcatgtaataatgcgactgcccattctcttaccaacctacatcctcta 540 caaacacaacatcttacaataaacagtacaagaagtggtggacagtcgctccattcttca 600 tcagacaccaatatcagtcaaataccgttcgaagatgatctaaacgactcggataacatt 660 tttatagacaagttatacaccttacccaagttatccactcctatcgaaattgatataaga 720 ataacgaaaactgcatcaatacctcatgagcgtcctgaggaacagtcaatattgaaggaa 780 tacacctcgggtgatattattcatggttattgtttaattgaaaatcggtcctctcaacca 840 ctgaaatttgaaatgttttatgtcactttagaagcgtacatatctgtaattgaccgtcag 900 aaagggaaaagaacgttaaagagatttttaagaatggtcgatttgagcgcatcttggtct 960 tatacaaacataaccccaagtacgggtattaatattgtccccggtgaaagggattttgac 1020 gatgccatcattggtctttcaaacagcagagaattgaagccgaacacaaagtataagaaa 1080 ttcttcatgttcaagcttcctacacagttattggacgtgacttgcaaacaagagcaattc 1140 tcacactgccttctgcctcccagctttggtatcgacaagtataaaaataattgtaaatac 1200 tctggcataaaagtaaatagtgtccttggctgtgggcatttaggtacaaaaggttcaccc 1260 attctgacacttgacatggcagatgataatttatcaataaattatacaattgatgccaaa 1320 attgtcggtaaagataaaagaacatctaagctgaatattatgaaagaaaaagaatataac 1380 ttgagagttatgcccttcccctttgctggtgtcactaatcaacaaaacgagaaaacgtgt 1440 ttgagacaactgaaaaatttggaaagcttgattgaagatagatttgaagctttgaacaag 1500 attttcaagaaactggaattaaatgaggccatttcgaatgtagatattcatgacacagat 1560 ataagcgggactttggacggtaatgaagatttggattccgatgagatattaagacgtaag 1620 ctagatcaactgcacatcaataacaggattgatgataccgccagccaatcaccatcctat 1680 gactccaaaaatatggctccaaaggaaaacctagtcgagactgagttacgctataagttt 1740 aaaaataagaataaatcaaattcaagtttattttctcattttttgagttcatcagaaacg 1800 gggtcatcttcaactggtccacatgtatataattccggattgattgtattatcagttaaa 1860 aaaccgcaatctacattaccttattggtcaccatcattgttgagaaaaaccaacaaattt 1920 gaagcaaagagtgaacaagaaaaggaaaactggcaaaggttaatgggcatgcttccagaa 1980 ggagtgaaaaccccactgaccaagttagatgtacatttgacttgtatccaatctaataat 2040 agtgcaggacataagccgccagaaataagctctgtaacgacagaatttgtggtcatcaca 2100 gcaaagtctgataattcgattcctatcaaattctgcactgaactgttgatgaatgagaat 2160 agattaaacaaactaaagacaaaatttttgacgtatcagaaaaaagttcatgaatatcgt 2220 aaaaaatttgaagaaaaccatgcgaagctaaacgagctttataatagaaatagagatcat 2280 ttcactccaaaagagcttttgttcacaaatttcatatctgatcaaataaacaatgatatt 2340 gacagtttagctggattaaaagttaacattattgatttacatgatatcttcaaaaagcaa 2400 atacatacttttgaagaagaaaacgaggatattatttcgaagaaaggaagttccaatcct 2460 ccttccgcgtcatccagtaataataatttcttacaagcaacatttagcaatggtgcatcc 2520 accgctactaagtttactcagcaaattgtgcatgaatgggaaaaagttaagccattacag 2580 tataagagggatgttacagttaatttgaagctcaaccccaacattaaagaaacgttagtg 2640 cccaatcttgaaacgtgtttgtgttgtagattttattgtgttcgagtaaacatcaaattt 2700 gataaccacttgggttctatgaaagttgatattccggttgatgtgaaaaagttacaaatt 2760 tag 2763 SEQIDNO:48 MTFTFSTSSRKNGRPPLKSVSTEDNIHLLRKRRQQQLSSNSTDNSLHPNSGQTPRASDSQ 60 DDDIRSASTTNLDRLRQEREENSLEMDCTQSRLSHRANMLVDVLPSFEMYNALHRHIPQG 120 NVDPDRHDFPPSYQEVRTQRMTILPSNDNSVERSQLTAVPGSENACNNATAHSLTNLHPL 180 QTQHLTINSTRSGGQSLHSSSDTNISQIPFEDDLNDSDNIFIDKLYTLPKLSTPIEIDIR 240 ITKTASIPHERPEEQSILKEYTSGDIIHGYCLIENRSSQPLKFEMFYVTLEAYISVIDRQ 300 KGKRTLKRFLRMVDLSASWSYTNITPSTGINIVPGERDFDDAIIGLSNSRELKPNTKYKK 360 FFMFKLPTQLLDVTCKQEQFSHCLLPPSFGIDKYKNNCKYSGIKVNSVLGCGHLGTKGSP 420 ILTLDMADDNLSINYTIDAKIVGKDKRTSKLNIMKEKEYNLRVMPFPFAGVTNQQNEKTC 480 LRQLKNLESLIEDRFEALNKIFKKLELNEAISNVDIHDTDISGTLDGNEDLDSDEILRRK 540 LDQLHINNRIDDTASQSPSYDSKNMAPKENLVETELRYKFKNKNKSNSSLFSHFLSSSET 600 GSSSTGPHVYNSGLIVLSVKKPQSTLPYWSPSLLRKTNKFEAKSEQEKENWQRLMGMLPE 660 GVKTPLTKLDVHLTCIQSNNSAGHKPPEISSVTTEFVVITAKSDNSIPIKFCTELLMNEN 720 RLNKLKTKFLTYQKKVHEYRKKFEENHAKLNELYNRNRDHFTPKELLFTNFISDQINNDI 780 DSLAGLKVNIIDLHDIFKKQIHTFEEENEDIISKKGSSNPPSASSSNNNFLQATFSNGAS 840 TATKFTQQIVHEWEKVKPLQYKRDVTVNLKLNPNIKETLVPNLETCLCCRFYCVRVNIKF 900 DNHLGSMKVDIPVDVKKLQI 920 SEQIDNO:49 atgcaagcccaaggttcacaatcgaatgtagggtctttgaggagtaattgctctgacaat 60 tcactaccgaacaatcatgttatgatgcactgcgatgaaagcagcggcagcccgcacagc 120 gagcacaacgattatagttacgaaaagaccaatctggaaagtacggcatcaaatagtcgt 180 gaacacagagacaaccagctaagtaggttgaagagtgaggaatacgttgttccaaagaat 240 caacgtaggggactattgcctcaactcgccattataccggagttcaaggatgccagagat 300 tatccaccgatgatgaaaaagatgattgtcttcttgattgcgttttcctccatgatgggc 360 cccatgggcacatctatcatttttccagcgatcaactcaatcacaacagaatttaaaaca 420 tcagtgattatggtaaacgtttcaattggtgtgtaccttttaagtcttggtgttttccca 480 ttgtggtggtcttctctatccgagctagagggcagaagaactacttacataacttcattt 540 gcattattgtttgcatttaatatcgggtctgctctagctcctgatatcaactcatttatt 600 gccttgagaatgctctgtggggctgcttctgccagtgttcaaagtgtaggtgctggaaca 660 gtggctgatttatatattagcgaagatagaggtaaaaatttgagttattactatttgggt 720 ccactactggcgccgctactatctccaatttttggatctttgttagtgaatcgctggccc 780 tggagatccactcaatggtttatggttattttatccggatgtaatgtcattcttttgacg 840 gtgttactacctgaaacattaagaaaacaagattctaaaggcgctatcgctcaaattttg 900 gctgaaagacgtattcaagtagacaataacgaacgtggagagatacaagaagattatcag 960 aggggagaagatgagacagatcgaattgaaaaccaagttgccacattatctactgagaag 1020 cataactacgttggagaggtaagggatcaagactcgctagatttagaaagtcactctagc 1080 cccaatacttatgatggtcgagctggagaaacccaattgcaacggatttatacagaggcg 1140 agtagaagtctgtatgaatatcagctagatgatagcggtatcgatgcaacaacagcacaa 1200 gttacgagaataagatcaacagatccaaagttagcgagatcgattcgagaaaatagtctg 1260 agaaaattacaaaccaacctggaagagcaagtcaaaaaagtgctatccagtaatggaggt 1320 gaaatcgctcctaaacaggtatcagcggtgaggaaggtctgggacaccttttttgtttat 1380 tttatcaagcctttaaaatcattgcacttcctagaatatccacccgtggcacttgcaata 1440 acattttccgcaatttccttttccacagtatactttgttaatatgacagttgaatataaa 1500 tattcaaggcctccttacaactttaaaccattatacattggtctactgtatattccgaat 1560 tctgtaacatactttttcgcctcaatttacggtggacgttgggtggacatgcttttaaaa 1620 agatacaaagagaaatatggaattcttgctcctgaagctcgtatatcgtggaatgttgtt 1680 acatctgtaatatctttccccattgcgctattgatatttggctggtgcctagataaaaaa 1740 tgccactgggtaacgccactaattggaacagccctctttggatatgcagctatgatgaca 1800 attggtgctaccctttcctatttagtcgattcattgccgggaaagggtgccaccggtgtt 1860 gctttgaataatttaataaggcaaatcttggctgcaaccgcagtctttgtcaccacaccc 1920 atgttaaacggtatgggaactgggtgggctttcacaatgctggcctttatcgtcttgggt 1980 gctagcagtgtacttataatactgaaaaagcacggtgattactggagagagaactacgat 2040 ttacaaaaattgtacgacaaaattgattaa 2070 SEQIDNO:50 MQAQGSQSNVGSLRSNCSDNSLPNNHVMMHCDESSGSPHSEHNDYSYEKTNLESTASNSR 60 EHRDNQLSRLKSEEYVVPKNQRRGLLPQLAIIPEFKDARDYPPMMKKMIVFLIAFSSMMG 120 PMGTSIIFPAINSITTEFKTSVIMVNVSIGVYLLSLGVFPLWWSSLSELEGRRTTYITSF 180 ALLFAFNIGSALAPDINSFIALRMLCGAASASVQSVGAGTVADLYISEDRGKNLSYYYLG 240 PLLAPLLSPIFGSLLVNRWPWRSTQWFMVILSGCNVILLTVLLPETLRKQDSKGAIAQIL 300 AERRIQVDNNERGEIQEDYQRGEDETDRIENQVATLSTEKHNYVGEVRDQDSLDLESHSS 360 PNTYDGRAGETQLQRIYTEASRSLYEYQLDDSGIDATTAQVTRIRSTDPKLARSIRENSL 420 RKLQTNLEEQVKKVLSSNGGEIAPKQVSAVRKVWDTFFVYFIKPLKSLHFLEYPPVALAI 480 TFSAISFSTVYFVNMTVEYKYSRPPYNFKPLYIGLLYIPNSVTYFFASIYGGRWVDMLLK 540 RYKEKYGILAPEARISWNVVTSVISFPIALLIFGWCLDKKCHWVTPLIGTALFGYAAMMT 600 IGATLSYLVDSLPGKGATGVALNNLIRQILAATAVFVTTPMLNGMGTGWAFTMLAFIVLG 660 ASSVLIILKKHGDYWRENYDLQKLYDKID 689 SEQIDNO:51 atgactgaattgtgtcctgtctacgcccctttctttggtgccattggttgtgcctctgca 60 attatcttcacctcattaggtgctgcttacggtactgctaagtctggtgttggtatctgt 120 gccacttgtgtgttgagaccagacctattattcaagaacattgttcctgttattatggct 180 ggtatcattgccatttacggtttagttgtttccgttttggtttgttattcgttgggtcaa 240 aagcaagctttgtacaccggtttcatccaattgggtgccggtctatcagtcggtttgagt 300 ggtctagctgctggtttcgctattggtattgtcggtgatgcaggtgttagaggttcctct 360 caacaaccaagattattcgtcggtatgattttgattttgatttttgctgaagttttgggt 420 ctatacggtttgattgttgctttgttgttgaactccagggctactcaagatgttgtctgt 480 taa 483 SEQIDNO:52 MTELCPVYAPFFGAIGCASAIIFTSLGAAYGTAKSGVGICATCVLRPDLLFKNIVPVIMA 60 GIIAIYGLVVSVLVCYSLGQKQALYTGFIQLGAGLSVGLSGLAAGFAIGIVGDAGVRGSS 120 QQPRLFVGMILILIFAEVLGLYGLIVALLLNSRATQDVVC 160 SEQIDNO:53 atgacaaggttcatgaacagctttgccaaacaaacgctgggatatggcaatatggcgaca 60 gtggagcaagagagctcagctcaggctgttgattctcattcaaacaacacaccgaagcaa 120 gctaagggtgttcttgcagaggaactaaaggatgcattgcggttccgggacgaaagagtt 180 agtattattaatgcagagccttcttcaacactgttcgtcttttggtttgtggtttcatgc 240 tatttccctgtgattactgcctgcttgggtcccgtagctaacactatctcgatagcctgt 300 gtagttgaaaaatggagatccttaaagaacaactccgtggtgacaaatccacgaagcaat 360 gacaccgatgttttgatgaatcaagtaaagacagtttttgatcctcctggtatttttgcc 420 gttaatatcatctctttggtactgggttttacgtcaaatattatactaatgctacatttc 480 agtaagaagttgacgtatcttaaatctcagttaataaatataacaggatggacaatagct 540 ggagggatgcttttggtggacgtgattgtatgctccttgaatgacatgcccagcatctac 600 agtaagactatcggattttggtttgcctgtatcagttctggtctatatttggtatgcacc 660 attattttaacaatacattttattggatataaattaggaaaatatcctccaacgttcaac 720 cttttgcccaatgaaagaagtatcatggcatacactgtactattgtctttatggttgatt 780 tggggtgcgggtatgtttagcggtttattgcacatcacttacggaaatgcattatatttc 840 tgcacggtatcattattaaccgtgggactaggtgacatcctgcccaagtcggttggcgcc 900 aaaatcatggttttaatcttttcgctatctggtgttgtcttgatgggtttaatagtgttt 960 atgacaagatccatcattcaaaagtcctctggcccaattttctttttccacagagttgaa 1020 aaaggcaggtccaaatcgtggaaacattatatggatagtagtaaaaatttatctgaaagg 1080 gaagcgttcgacttaatgaagtgtatccgacaaacggcctcaaggaagcagcattggttt 1140 tctttgtcggtgactattgcaattttcatggctttttggttattgggagctcttgtattc 1200 aaattcgcagaaaattggtcgtacttcaattgtatttacttttgtttcttgtgcttatta 1260 accattggatacggagactatgctccaaggactggtgcaggccgtgctttttttgtgatt 1320 tgggcgttgggagccgtgccattaatgggggctatcctatctacagtcggtgatctgttg 1380 tttgacatttccacttctctggatattaagatcggtgaatcattcaataataaagtcaag 1440 tccatcgtttttaatgggcgtcaaagagcactttcctttatggtgaacactggagaaatt 1500 ttcgaagaatctgacacagctgatggtgatctggaagaaaatacaacgagctcacaatcc 1560 agtcaaatttctgaattcaacgataataattcagaagagaatgattctggagtgacatcc 1620 cctcctgcaagcctgcaagaatcattttcttcattatcaaaagcatctagcccagaggga 1680 atacttcctctagaatatgtttcttctgctgaatatgcactacaggactcggggacctgt 1740 aatttaaggaacttgcaagagctacttaaagccgtcaaaaaactacatcggatatgtctg 1800 gcggataaagattacacacttagtttttccgactggtcgtacattcataaactacatttg 1860 aggaacattacagatattgaggagtacacacgcggacccgaattttggatatcacctgat 1920 acgcccctcaagttcccgttaaatgaacctcattttgcttttatgatgcttttcaagaac 1980 atagaagaattagttggtaatctagtagaagacgaagagctttataaagttataagcaaa 2040 agaaaatttttgggtgagcatagaaagacactttga 2076 SEQIDNO:54 MTRFMNSFAKQTLGYGNMATVEQESSAQAVDSHSNNTPKQAKGVLAEELKDALRFRDERV 60 SIINAEPSSTLFVFWFVVSCYFPVITACLGPVANTISIACVVEKWRSLKNNSVVTNPRSN 120 DTDVLMNQVKTVFDPPGIFAVNIISLVLGFTSNIILMLHFSKKLTYLKSQLINITGWTIA 180 GGMLLVDVIVCSLNDMPSIYSKTIGFWFACISSGLYLVCTIILTIHFIGYKLGKYPPTFN 240 LLPNERSIMAYTVLLSLWLIWGAGMFSGLLHITYGNALYFCTVSLLTVGLGDILPKSVGA 300 KIMVLIFSLSGVVLMGLIVFMTRSIIQKSSGPIFFFHRVEKGRSKSWKHYMDSSKNLSER 360 EAFDLMKCIRQTASRKQHWFSLSVTIAIFMAFWLLGALVFKFAENWSYFNCIYFCFLCLL 420 TIGYGDYAPRTGAGRAFFVIWALGAVPLMGAILSTVGDLLFDISTSLDIKIGESFNNKVK 480 SIVFNGRQRALSFMVNTGEIFEESDTADGDLEENTTSSQSSQISEFNDNNSEENDSGVTS 540 PPASLQESFSSLSKASSPEGILPLEYVSSAEYALQDSGTCNLRNLQELLKAVKKLHRICL 600 ADKDYTLSFSDWSYIHKLHLRNITDIEEYTRGPEFWISPDTPLKFPLNEPHFAFMMLFKN 660 IEELVGNLVEDEELYKVISKRKFLGEHRKTL 691 SEQIDNO:55 atggactgggcaatcaatgtcgcccatccacgattactttacaaggatcctaaactttca 60 gtaacgtttattgtgccgagcttatttcatatcattattgctttcgtgttattaggaata 120 tgtgcatccgattttctttgccccaacgtggcccatatatcagatcccaacagccttcga 180 tcgaatggttctttagtctcaaaaacggcgtcccatgcatctcatactggggcattaatg 240 gcagttctactatcttggtgtaactcttcgcctgacctattttccaacttaatgagctgg 300 gcaacctctacgagagaaacaaggtcaacctcagtatcgctatcaattggtgaggtgctt 360 ggcgcttgcggcattatcctgtgcattgtagagggctccatttttattattatgtcaaga 420 actcacattgaaatctcgcaaattcaaaaactatccatcatgagagacttgttattttct 480 ttagctgccatgtgcgtaatgagttacgtttcccttatgaatcaggtcactgtgctgaat 540 tgccttttgatggcgttcctttatgccttttatctagtcgttaagttaactttcaagctt 600 aatcattctgcagaaaccccagatgaaactgctgcggatacgagcctcagagaaaactcc 660 gtttctccttttttggatgactctctgatggcttctggtttactaccaccaatacaacct 720 ggctttgacatatccaattctataacacacggcattaagcctagtttgctatctgctatg 780 gatttcaatagtttcttatcaatgcttgaaaactcatctttggaggaggatgactcaagg 840 aatgaaatggcagaattgaacactctacgtagcatgacgccgggacaacattggtccgcc 900 tctgcaacagttgcaggagaggcaacgagtgctggaagacctttcagtgagccaacgaat 960 gcgtttacggaatatagagattctgaaagagcaataaatagttccccagcggtgttcgcc 1020 ccctaccgtgacaaccctgatgatgaagagtctcaagagcaagtattattggagacaaca 1080 acgcatggtcattttggtgcgcaagaaatgcgaaggttctccaaaaggtctctgggctgg 1140 attataaaaattttcataccacatctctcaaatttttcccagaaatccatctcagatgcg 1200 atcttttccataataactgttccgtttttcattattttcaaactatcatgtcctcaaccg 1260 ccttcagatattttgagttatgatcccactttgaacagatactctttaacaacgttaccc 1320 ataattttattatttatccaatcaattactgcacccttcctcctttgcagtatactttct 1380 gtgcttttgacatatcatctaggctatctcgtttaccttttccctcttatattagctatg 1440 gccttaattttactattgacggcttttattacaaaggtaaatctgcataacaagtttact 1500 ctgtcattagacagctctaacattttacaggaaaagctacaaaaaagaaaactcctcgaa 1560 aggcttaacacaagcatccaaataatttttctagctatcggcataataaatatcataatt 1620 tggatatcacttttagccaattctcttattgagatgatggaaatttaccaaaaaatatta 1680 ggattatcgaaagctattttgggccttaccattttcgcatggggcaactcagtaggagac 1740 ttgatctccaacatatctatgtgcaggctctacaaaacccaaactcactaccaagacaga 1800 gttcgtttagccacaaaattttttatgatatcatgcgcatcttgcttaggaggcgtaatg 1860 ctgaattctatgggtggaataggctttagtgggctagtatcaatgctttttattggcgct 1920 tttaatgataacgaatggtggttcctaagaaaggttaaattacaagaaacaagtcaattg 1980 gataatacattaaattacaaattcatagtttcttgcgtcttcattatcctacagattatt 2040 ctcttgctgttattcttcggagggcctaacaatattaaacggcgcctcacaaaggagatg 2100 aagttagtcggaatctctatgtgcggactatgggcactagccacgttgattaatatactt 2160 ctagaactgtttagctaa 2178 SEQIDNO:56 MDWAINVAHPRLLYKDPKLSVTFIVPSLFHIIIAFVLLGICASDFLCPNVAHISDPNSLR 60 SNGSLVSKTASHASHTGALMAVLLSWCNSSPDLFSNLMSWATSTRETRSTSVSLSIGEVL 120 GACGIILCIVEGSIFIIMSRTHIEISQIQKLSIMRDLLFSLAAMCVMSYVSLMNQVTVLN 180 CLLMAFLYAFYLVVKLTFKLNHSAETPDETAADTSLRENSVSPFLDDSLMASGLLPPIQP 240 GFDISNSITHGIKPSLLSAMDFNSFLSMLENSSLEEDDSRNEMAELNTLRSMTPGQHWSA 300 SATVAGEATSAGRPFSEPTNAFTEYRDSERAINSSPAVFAPYRDNPDDEESQEQVLLETT 360 THGHFGAQEMRRFSKRSLGWIIKIFIPHLSNFSQKSISDAIFSIITVPFFIIFKLSCPQP 420 PSDILSYDPTLNRYSLTTLPIILLFIQSITAPFLLCSILSVLLTYHLGYLVYLFPLILAM 480 ALILLLTAFITKVNLHNKFTLSLDSSNILQEKLQKRKLLERLNTSIQIIFLAIGIINIII 540 WISLLANSLIEMMEIYQKILGLSKAILGLTIFAWGNSVGDLISNISMCRLYKTQTHYQDR 600 VRLATKFFMISCASCLGGVMLNSMGGIGFSGLVSMLFIGAFNDNEWWFLRKVKLQETSQL 660 DNTLNYKFIVSCVFIILQIILLLLFFGGPNNIKRRLTKEMKLVGISMCGLWALATLINIL 720 LELFS 725 SEQIDNO:57 atgaactcatggaacctgagttcttcaataccgataatacatacgcctcatgaccatccc 60 ccgacatcagaaggaactccagatcaaccaaataataaccgaaaagatgataaactgcac 120 aaaaaaagaggcgattcagatgaggacttaagccctatatggcattgtgtcgtctccggt 180 gggattggtggaaaaataggagattctgcgatgcattcattggatactgttaagacaaga 240 caacagggcgcacccaatgtcaaaaaatacaggaacatgatctctgcatatcgtaccatt 300 tggctagaagaaggcgtgagaagggggctatacggcggttacatggctgccatgttaggc 360 tccttcccgtcagcggcaatcttctttgggacctatgaatatactaagagaacaatgata 420 gaagattggcagattaacgataccatcacacatttgagcgctggatttcttggcgatttt 480 atctccagttttgtttatgttccatcagaggtcctaaagacaaggctacaattgcaagga 540 aggttcaataatcctttctttcaatctggctataattattcgaatttaagaaatgccata 600 aagacagttataaaagaagaagggtttcgctcactattttttggatacaaagccacttta 660 gccagagatttgccatttagtgcattgcagtttgccttctacgaaaagtttaggcaattg 720 gctttcaagattgaacagaaagatggtagggatggtgagttgtctatacctaatgaaata 780 ttgactggtgcctgtgcaggtggactggcgggaatcattaccacaccaatggatgttgtt 840 aagactagagtccaaactcaacagccgcccagccaaagcaacaaatcatactcagtaaca 900 catccacatgtaacaaacggcagaccggcagcactttccaactcgatttcgctcagcctt 960 cggacggtctaccaatctgaaggtgtgttaggtttctttagtggcgttggccctagattc 1020 gtctggacaagtgttcagagcagtataatgttgcttctgtatcaaatgaccctacgcgga 1080 ttaagtaacgcatttccaacggactaa 1107 SEQIDNO:58 MNSWNLSSSIPIIHTPHDHPPTSEGTPDQPNNNRKDDKLHKKRGDSDEDLSPIWHCVVSG 60 GIGGKIGDSAMHSLDTVKTRQQGAPNVKKYRNMISAYRTIWLEEGVRRGLYGGYMAAMLG 120 SFPSAAIFFGTYEYTKRTMIEDWQINDTITHLSAGFLGDFISSFVYVPSEVLKTRLQLQG 180 RFNNPFFQSGYNYSNLRNAIKTVIKEEGFRSLFFGYKATLARDLPFSALQFAFYEKFRQL 240 AFKIEQKDGRDGELSIPNEILTGACAGGLAGIITTPMDVVKTRVQTQQPPSQSNKSYSVT 300 HPHVTNGRPAALSNSISLSLRTVYQSEGVLGFFSGVGPRFVWTSVQSSIMLLLYQMTLRG 360 LSNAFPTD 368 SEQIDNO:59 atgtccgtacaaaaagaagaatacgatattgtagaaaaggcccaattatctgtgtccgca 60 gaaagcttaacatcagattcggagagtatttcacataacccatttgacgattttcataaa 120 gcagagcgttggagaaaagtctatgaatccagtggttatgaaggcttgtctaaattcgat 180 cctgagtttacatggacaaaggatgaggaaaagaaattggtaagaaaaatggacttgaag 240 atttttttgtgggtttttattatgtttgcctttttggatttaataaggaaaaatattgca 300 agggcagtttcagacaacttcattgttgacttgaaaatgaacacgaacgactacaacctt 360 ggccaaactgtttatctagttatatttctagcaagtgaactacccggcaatctgctgtcc 420 aaaagatttggtccagaaagggtcattccggttcaaattgtgttgtggagtgtaatttgt 480 attactcaagctggtctgaaaaatcgaggtcaatttattgctactagatgcttattagga 540 atggtacagggcgggttcatcccggacaatattctatacttgtcatattattatactgga 600 gctgagctcacattccgcctaagtttcttttggtgtgctatacctcttttccaaatttta 660 ggctctcttttagcttccggaatcatagagatgaggggtattcataacttagctggctgg 720 cagtacctatttataattgaagggtttctgtccctttctgttggcgtggcatccttttat 780 ttaatgcgtagaggacctacgcaaactggtgagtctgcatttcacaaaggaaaatcgtta 840 ttcactgagtatgaggagaaaattatggttaacagaattttaagggatgacccatcaaag 900 ggtgacatgagtaaccgacaaccagttaccttcaaggagattttgtacactctaacagaa 960 tttgatctatggccattgtttatccaaggtattacagcattcatatctcttcaaacagtt 1020 ggttcctatttatctttgatattaaagagtttaaattactctacatttctttcgaacatt 1080 ttagcaattccaggccaagccctgctgctaataaatttaccattagcggcactattatcg 1140 cgtaaattgaaagaaaaatcactttgtgtgggaattgccaacgtttgggtgctccctttc 1200 atagtttctctggtcgctttaccgactgacacaaacccctggatcaagtatatattacta 1260 accggtatacttggtcttccctatacacattccattcttgctggttgggtctccgagatt 1320 tcaaattcggtaagatcgcgtacagtgggcacagcgttatacaatatgagtgcccaagtt 1380 ggagcaatcattgcttctaacatgtatagaaatgatgataaaccttactatactagaggt 1440 aacaaaatacttctaggattcacttgcttcaacatttgtatggctgttgctactaagttt 1500 tactatattagtaggaataaatacaaggaccgcaaatggaactctatgacaaaagaagag 1560 cagatcaattacttggacacaactaaagataagggaatgaagcgtcttgattataggttt 1620 attcactag 1629 SEQIDNO:60 MSVQKEEYDIVEKAQLSVSAESLTSDSESISHNPFDDFHKAERWRKVYESSGYEGLSKFD 60 PEFTWTKDEEKKLVRKMDLKIFLWVFIMFAFLDLIRKNIARAVSDNFIVDLKMNTNDYNL 120 GQTVYLVIFLASELPGNLLSKRFGPERVIPVQIVLWSVICITQAGLKNRGQFIATRCLLG 180 MVQGGFIPDNILYLSYYYTGAELTFRLSFFWCAIPLFQILGSLLASGIIEMRGIHNLAGW 240 QYLFIIEGFLSLSVGVASFYLMRRGPTQTGESAFHKGKSLFTEYEEKIMVNRILRDDPSK 300 GDMSNRQPVTFKEILYTLTEFDLWPLFIQGITAFISLQTVGSYLSLILKSLNYSTFLSNI 360 LAIPGQALLLINLPLAALLSRKLKEKSLCVGIANVWVLPFIVSLVALPTDTNPWIKYILL 420 TGILGLPYTHSILAGWVSEISNSVRSRTVGTALYNMSAQVGAIIASNMYRNDDKPYYTRG 480 NKILLGFTCFNICMAVATKFYYISRNKYKDRKWNSMTKEEQINYLDTTKDKGMKRLDYRF 540 IH 542 SEQIDNO:61 atgtcatctgacaactctaaacaagataaacaaattgaaaaaacagccgcccagaagata 60 tcgaagtttggttcgtttgtggctggtgggctagcagcatgtatagctgttacagttact 120 aatccgatcgaattgattaaaatcagaatgcagcttcaaggtgaaatgtcagcatcagct 180 gcaaaagtttataaaaatccaatccaaggtatggcggtaattttcaaaaacgaaggtata 240 aaaggtctgcaaaaagggttaaatgctgcttatatctatcaaattgggctaaatggttcc 300 agattagggttttatgagccaatcagatcatcattaaatcagcttttcttcccagatcaa 360 gagccacataaggtacagagcgtcggagttaacgtcttttctggtgccgcatctggtata 420 attggtgcagtcattggctctccattattcttggtgaaaacaagacttcaatcatattcc 480 gagtttataaaaattggtgaacaaacgcactacaccggtgtttggaacgggttagtaacc 540 atttttaaaaccgaaggtgttaagggtctattcagaggtattgatgcggcaattttaagg 600 acaggtgctggttcctctgttcaactacctatctacaacacagcaaagaacattttggtc 660 aaaaatgatctgatgaaagatggcccagcattacatttaactgctagtactatctctggg 720 ttaggtgttgccgtcgttatgaacccatgggatgtcattttgacaagaatctataatcaa 780 aaaggtgacttgtacaagggacctatagattgtttggtcaaaactgttagaatcgaaggt 840 gtaaccgctttgtataagggttttgcagctcaagtgttcagaatcgcacctcatacaatc 900 atgtgtttgaccttcatggaacagacaatgaaactagtttattcgatagagtcgagagtt 960 ttaggccataattaa 975 SEQIDNO:62 MSSDNSKQDKQIEKTAAQKISKFGSFVAGGLAACIAVTVTNPIELIKIRMQLQGEMSASA 60 AKVYKNPIQGMAVIFKNEGIKGLQKGLNAAYIYQIGLNGSRLGFYEPIRSSLNQLFFPDQ 120 EPHKVQSVGVNVFSGAASGIIGAVIGSPLFLVKTRLQSYSEFIKIGEQTHYTGVWNGLVT 180 IFKTEGVKGLFRGIDAAILRTGAGSSVQLPIYNTAKNILVKNDLMKDGPALHLTASTISG 240 LGVAVVMNPWDVILTRIYNQKGDLYKGPIDCLVKTVRIEGVTALYKGFAAQVFRIAPHTI 300 MCLTFMEQTMKLVYSIESRVLGHN 324 SEQIDNO:63 atgctatcttcagaagattttggatcttctgggaaaaaggaaacttctcctgattcgata 60 tcgatacgttcctttagtgccgggaataatttccaatcatcatcaagtgagaaaacttat 120 tctaagcaaaaatccgggagtgacaaacttatacatagatttgcggattcattcaaaaga 180 gccgagggtagcactacaagaactaagcaaataaatgaaaatacgtctgatttagaggat 240 ggcgttgagtctatcacgtcggattccaagttgaaaaagtccatgaagtcgcgccatgtt 300 gtcatgatgtctttagggacaggtattgggactggtcttttggtagctaatgcaaaaggt 360 ctacattacggtggtcctgctgcgctaataattggttacatcttggtttctttcgtgacg 420 tacttcatgatccaagctgcaggtgagatggcggtaacctatccgactttaccagcaaat 480 ttcaacgcatactcctccatattcatttccaaatcatttggattcgccacagtatggctt 540 tactgtttccaatggctaacggttttgcctttagagttaataaccgcgtctatgactatt 600 caattttggaatgataaaataaatccggacatttatattcttattttctatgttttctta 660 gtattcattcatttcttcggtgtaaaagcctatggtgaaacggaattcatcttcaattgc 720 tgtaaaattttaatgattgcaggtttcattattctttctattgttatcaactgtggtggg 780 gccggaaatgacggttatatcggggccacttattggcataatccaggtgcttttgcaggt 840 gacacatcgattggtaggttcaaaaacgtttgctatattttagttactgcttacttctcc 900 tttggtggtatggaattatttgcactaagtgttcaggaacagtctaaccctagaaaatct 960 actccggtggcagccaagagaagcatttatcgtatcgttgtgatttatcttttgactatg 1020 atcctcattggattcaatgttccatataatgatgaccaactaatgggcgcaggcggatcc 1080 gctacacatgcatctccctatgtcttagccgcttctattcacggtgtgaaaattgttcca 1140 catattatcaacgctgttattttgatttctgtggtttcagtggcaaattcctctttgtat 1200 gctggtccaagactgatttgctctttggcccaacaaggctacgcacccaagtttttagat 1260 tacgttgacagagagggcaggcccttgagagctcttattgtgtgttgcgttttcggcgtc 1320 attgcttttgttgcagcttcatcaaaggaagagatcgtgtttacatggttagcagctatc 1380 gcaggcttgagtgaattattcacatggacttccataatgttgtcccatctgcgattcaga 1440 caagcaatgaaagtacagggaaggtctctagacgagttgggatacaaggccacaacaggg 1500 atttggggttccatatacggtgtcttttttaatattttagtctttgttgcccaattttgg 1560 gtagcattggcccccttaggtaatgggggcaaatgcgatgcggaatccttctttcaaaat 1620 tatttagcttttccaatatggttggccttttacttcggatatatggtttacaaccgtgat 1680 tttacgctattaaatcccctcgacaagattgaccttgacttccacagacgcatttatgat 1740 ccagagctaatgagacaagaggacgaagaaaataaagaaaaactaaggaatatgtctttg 1800 atgagaaaagcttatcatttctggtgttaa 1830 SEQIDNO:64 MLSSEDFGSSGKKETSPDSISIRSFSAGNNFQSSSSEKTYSKQKSGSDKLIHRFADSFKR 60 AEGSTTRTKQINENTSDLEDGVESITSDSKLKKSMKSRHVVMMSLGTGIGTGLLVANAKG 120 LHYGGPAALIIGYILVSFVTYFMIQAAGEMAVTYPTLPANFNAYSSIFISKSFGFATVWL 180 YCFQWLTVLPLELITASMTIQFWNDKINPDIYILIFYVFLVFIHFFGVKAYGETEFIFNC 240 CKILMIAGFIILSIVINCGGAGNDGYIGATYWHNPGAFAGDTSIGRFKNVCYILVTAYFS 300 FGGMELFALSVQEQSNPRKSTPVAAKRSIYRIVVIYLLTMILIGFNVPYNDDQLMGAGGS 360 ATHASPYVLAASIHGVKIVPHIINAVILISVVSVANSSLYAGPRLICSLAQQGYAPKFLD 420 YVDREGRPLRALIVCCVFGVIAFVAASSKEEIVFTWLAAIAGLSELFTWTSIMLSHLRFR 480 QAMKVQGRSLDELGYKATTGIWGSIYGVFFNILVFVAQFWVALAPLGNGGKCDAESFFQN 540 YLAFPIWLAFYFGYMVYNRDFTLLNPLDKIDLDFHRRIYDPELMRQEDEENKEKLRNMSL 600 MRKAYHFWC 609 SEQIDNO:65 atggaacctaagcgaaagagcgggtcactagccaagcatgatttgccgcaattttatctt 60 ttaattatgttatatttggctcaaggcatacctgtaggattggccttcggtaccgtaccg 120 tttctactgaaatctttagcaaaggagacctcgtttacatcactgggaattttctctatg 180 gctacatatccatattctttaaagatcatatggtcaccaatagtagactcactgtacaac 240 aagcgcatcggtagaagaagatcatggatcattccagtacaatttgttagtggatttgtg 300 ctatgggcattagggtggtgcatatcacaaggcataatcttcgatggtgtcgacgatgcg 360 ttccataatcgcggtaatggcactttacacagtgtcagtataaaaaatttgacgtggtgg 420 tttggcctgttagtttttctgtgtgccactcaagacatcgcagttgatggttgggcgttg 480 acgattttgtccaaagaatccctatcatatgcatctaccgcgcaaacaataggtttgaat 540 attggttattttatgtcatttaccattttcctgtcgttgaattcctctgatttcgccaat 600 aagtatttcagaaacatcccactggatcacgggttcattagtcttggtgggtacatgaaa 660 ttctcgggcatgctttacattgtaataaccatatatatcatcttttgcaccaaggaaaaa 720 ccctacgtagagtatttgcccaaagtggagcccataaatacaagtgacggagggtcaaag 780 ccgataagtattgagtatgacgacggtgatgtggtgtcaactcagaatacaagcagtata 840 aagtacatttaccgctgctttataaaagtgttgaaattgaagtccgtaagaagcctagcc 900 ttcattcacatgatttcgaaatttgcctttcaatgcaacgaagccgccacaaacctgaaa 960 ctactagagcaaggcttcaaaagagaagacttggctgtgacagtactcatagacctgccg 1020 ttcgaaatcatatttgggtactatgttgttaaatggagctccgacaaggaccccatgatt 1080 cgtgacaatagaagattaagaaacagcacgggcaccaacaaggtcatcaagttcttagtt 1140 ggggatgccggcgttttaacaccatggttgtggggctttttgggccgtctggcagccgcg 1200 gtcttgggaagttacgtggtgaagcaattccccaaggatggtgaaatatccacgggttat 1260 ttttgtctcgtgatattccagcacctcttaggttccttcatgaatactgtccagttcatt 1320 ggaatatcggccttccatacaagagttgcagaccccgtgctgggtggcacatatatgaca 1380 ttgttaaataccctcagcaacttcggtgggacatggccgcggttaatcattatgtccatg 1440 atcaactacttcaccgtgtatcagtgcactattcctggcacaaataaagtatacgtaact 1500 cacggcggcagcatgcaagcgtgcaccgagcttttgaatggcaccgtgaccatcctgcgt 1560 gacggctattacatcaccaatctcatatgtattgtagtcggacttttcctatattttgga 1620 tatttgaaaaggaaaatcctccatttacaaagtctgccaatcagttcctggagatgtacg 1680 taa 1683 SEQIDNO:66 MEPKRKSGSLAKHDLPQFYLLIMLYLAQGIPVGLAFGTVPFLLKSLAKETSFTSLGIFSM 60 ATYPYSLKIIWSPIVDSLYNKRIGRRRSWIIPVQFVSGFVLWALGWCISQGIIFDGVDDA 120 FHNRGNGTLHSVSIKNLTWWFGLLVFLCATQDIAVDGWALTILSKESLSYASTAQTIGLN 180 IGYFMSFTIFLSLNSSDFANKYFRNIPLDHGFISLGGYMKFSGMLYIVITIYIIFCTKEK 240 PYVEYLPKVEPINTSDGGSKPISIEYDDGDVVSTQNTSSIKYIYRCFIKVLKLKSVRSLA 300 FIHMISKFAFQCNEAATNLKLLEQGFKREDLAVTVLIDLPFEIIFGYYVVKWSSDKDPMI 360 RDNRRLRNSTGTNKVIKFLVGDAGVLTPWLWGFLGRLAAAVLGSYVVKQFPKDGEISTGY 420 FCLVIFQHLLGSFMNTVQFIGISAFHTRVADPVLGGTYMTLLNTLSNFGGTWPRLIIMSM 480 INYFTVYQCTIPGTNKVYVTHGGSMQACTELLNGTVTILRDGYYITNLICIVVGLFLYFG 540 YLKRKILHLQSLPISSWRCT 560 SEQIDNO:67 atggttagtaggttttatcagattccaggtacgcatcggccatcgtcggcaatatcttct 60 tcaaatgaatcttcttcactgttgtctgcaaggagaataagtcaaacatatttcaattat 120 caggcgacccctgaatgccaaaaagtttcctctaagtatgatcctgataacccaaacaaa 180 gataagttgggaacatacgatggggtatttgtgcctactgctttaaacgtattgtctatc 240 cttatgtttcttcgttttggcttcattttgggtcagttaggtattatatgcaccatcggt 300 cttctgctattgagttacactattaatcttctcaccacgttaagtatatctgctatatct 360 acaaacgggactgttaggggcgggggtgcttattatatgatttcaagaagtttaggacct 420 gaatttggtggatccattgggcttgtctttttcttagggcaggtgttcaatgcaggtatg 480 aacgcagtgggtattatcgaacctttactctataacttgggttattctgctcaaggcgag 540 ccacctgcagctttgggagagctactaccaagagggcattggcacgaatttacatatgcc 600 acggtcattcttttcttatgtttttctgtggcttttgttggctcgcaaacagtgtcaaga 660 gcagggaatattctttttttggtactggcagcttctatattttccattccactttctgca 720 ttgataagatcgccattcactgaaggcggtatcagttatacaggtccttcatggcaaact 780 tttcatgataacctgctccctcacttaacaaaaggtgcagcaggttcgttactcaaaggt 840 aaggaaacattcaatgatttatttggcgttttttttcctgctacagctggtatattcgcg 900 ggcgcaggaatgtcaagtgaattgagaaagccctctaaatcaattcctaagggtacctta 960 tggggtttacttttcacttttatctgttatgccgttgttgtcttctccatgggttgttcc 1020 attcccagaagatcgttatatgatgaagtacaaattatacagacgatcagttccgttcag 1080 tgggttatattcatgggtgaaatggctacttctcttttctccatcatagtggggatgctc 1140 ggtgctgcttatgtattagaagcaattgcaaaggataacattattcctggtttggagatt 1200 tttgctcattcaccgttatattcattgatttttacttggattctaacacagctatgtttg 1260 ttttcagacgtcaataaaatcgccacatttatcacaatgacattcttaatgacgtttgtg 1320 gtcatgaatttggcgtgcttcctattaggtatttcctctgctcccaatttcaggccctct 1380 ttcaaatactttaacaggtatactacagcaattggcgcattactttctgttgttgcgatg 1440 ttaatagttgatggcatctcagcgtctgtcttgtttttggctatgattttgctattttta 1500 ttcattcattatttttcaccaccgaagtcttggggtgatgtgtctcaaagtttaatatat 1560 catcaagtgagaaagtatttgcttcgcctacgtcaagacaatattaaatactggaggcct 1620 caaatattgctgtttgtagataatccaaggacgagctggaacttaataaggttttgcaat 1680 catttgaaaaaaggtggtttgtatattttaggccatgttgcagtaactgcggattttccg 1740 aagcaactaaatgaattaaaaactcagcagaaagcttggatgaagatcagagacatggca 1800 gcaataaaggcttttgtccaagttgggactggtccctcccttatatggggaattaggaat 1860 gtttttattggttccgggcttggaggtatgaaaccaaacattactgttgtcggttttttt 1920 gacctcgaaagttatagaaagcacatcccacaaagtcgcagccaaaataaccttcagaaa 1980 caggtggaaataaaagctacagtgccacgtagtacatgctctgatgtcaaaatcaatgtt 2040 ccattgcctacggatgagtgtaaaaatgaaaccaaagttaatgtacaacaatgggttcaa 2100 attgtagaagatctatcactgatgcaatccaatattgccatagcgcatggattcaaaaat 2160 ttagagataccgaacaaaagggacagctgctttccaaaaaaaactatagatctttatccc 2220 atccaaatgtgcggaaaagttgaggcaaagggtgaccagcctgcggctatcactactaac 2280 tttgatacgtatacactgattctacaattagctgccattttggttactgttcctgaatgg 2340 aagcgcacacattcgcttcgagttattttatttgtggaacaagaatatcatagaacgaac 2400 gaaactcaacgaatgaaaaagctattacaggttctaagaattgacgcagaggttttggta 2460 gtatctttagatcaattcagagtatacaacacaattgtcaagggagacccaatcgtgttt 2520 gattatgtcaactcgaaattggccgataatgaatggtggaaagatttggttgaagctcgt 2580 gatacattaaaaccgaagcggaggttttccactattgaacctcaaacgatagcaaagcaa 2640 tttacacaatcaagaaaatatacgtctggggttcagaaattgggtgtctcatttacaatg 2700 aatacgagaatgccaactaaccgcattgataccccatgcgagagtgaggactccgatttg 2760 gatacagatcttacgtcaattcgtgatgccttctcggcatcgactaatatttcagtaggt 2820 aaggacttaacgaccaaatcgaagaccggttccgacagaacaaatttactcgtaaagaat 2880 ttacaaagcgatgtgtcaacacagtcgttaagacccgttttctcgagtaatactttgccg 2940 aggacgagagtcgtggaagatggcacgggtgaacagccgacactgatcccaattgccgaa 3000 cctgacctttcgaatgggaacggtactgggagcggtattggcaacggcaacaaattaaag 3060 aaaccggttcttcccgaattatcaccttgttgttcaaaagatagtttagtcacagcgatg 3120 caaaatttaggtttcaatgatcttcccagcactgctcaacatttggttctgaatgatgtg 3180 atgacacaaatgtcaaagagttcggatttaattttttcaaccttgccagttccagctctt 3240 ggaacacatgaagatcacgatgcaagtttacaatatgtcgaggacttggatatttggttg 3300 gagggcttacctccatgcatgttaatcaattcgcaaaccatgacagtaactactgcatta 3360 tag 3363 SEQIDNO:68 MVSRFYQIPGTHRPSSAISSSNESSSLLSARRISQTYFNYQATPECQKVSSKYDPDNPNK 60 DKLGTYDGVFVPTALNVLSILMFLRFGFILGQLGIICTIGLLLLSYTINLLTTLSISAIS 120 TNGTVRGGGAYYMISRSLGPEFGGSIGLVFFLGQVFNAGMNAVGIIEPLLYNLGYSAQGE 180 PPAALGELLPRGHWHEFTYATVILFLCFSVAFVGSQTVSRAGNILFLVLAASIFSIPLSA 240 LIRSPFTEGGISYTGPSWQTFHDNLLPHLTKGAAGSLLKGKETFNDLFGVFFPATAGIFA 300 GAGMSSELRKPSKSIPKGTLWGLLFTFICYAVVVFSMGCSIPRRSLYDEVQIIQTISSVQ 360 WVIFMGEMATSLFSIIVGMLGAAYVLEAIAKDNIIPGLEIFAHSPLYSLIFTWILTQLCL 420 FSDVNKIATFITMTFLMTFVVMNLACFLLGISSAPNFRPSFKYFNRYTTAIGALLSVVAM 480 LIVDGISASVLFLAMILLFLFIHYFSPPKSWGDVSQSLIYHQVRKYLLRLRQDNIKYWRP 540 QILLFVDNPRTSWNLIRFCNHLKKGGLYILGHVAVTADFPKQLNELKTQQKAWMKIRDMA 600 AIKAFVQVGTGPSLIWGIRNVFIGSGLGGMKPNITVVGFFDLESYRKHIPQSRSQNNLQK 660 QVEIKATVPRSTCSDVKINVPLPTDECKNETKVNVQQWVQIVEDLSLMQSNIAIAHGFKN 720 LEIPNKRDSCFPKKTIDLYPIQMCGKVEAKGDQPAAITTNFDTYTLILQLAAILVTVPEW 780 KRTHSLRVILFVEQEYHRTNETQRMKKLLQVLRIDAEVLVVSLDQFRVYNTIVKGDPIVF 840 DYVNSKLADNEWWKDLVEARDTLKPKRRFSTIEPQTIAKQFTQSRKYTSGVQKLGVSFTM 900 NTRMPTNRIDTPCESEDSDLDTDLTSIRDAFSASTNISVGKDLTTKSKTGSDRTNLLVKN 960 LQSDVSTQSLRPVFSSNTLPRTRVVEDGTGEQPTLIPIAEPDLSNGNGTGSGIGNGNKLK 1020 KPVLPELSPCCSKDSLVTAMQNLGFNDLPSTAQHLVLNDVMTQMSKSSDLIFSTLPVPAL 1080 GTHEDHDASLQYVEDLDIWLEGLPPCMLINSQTMTVTTAL 1120 SEQIDNO:69 atgagtatttcaaattggatcaccactgcgtatttaattacatcaacatcttttcaacct 60 ctttatgggtcattttctgatgcacttggtcgaagaaactgccttttctttgctaatggg 120 gcttttaccattggatgtctagcctgtggtttctcgaaaaacatctacatgcttagtttt 180 atgagagcattgacaggcataggaggtggtggcttgatcacactttctacaatcgtaaat 240 tcagacgttattccaagttcgaaaagaggaatttttcaagcgtttcagaatttacttttg 300 ggatttggtgccatatgtggagcgtctttcggtggcacaatagcgtcgagcattggttgg 360 aggtggtgttttctcatccaagtacccatatctgtgattagttccatattaatgaattat 420 tatgtacctaatcagaaagaatataatcgtcaaaattctagcatattccaaaatcccgga 480 aaaatactcagggacatagatgttatgggctcaattcttattataactggtctcacacta 540 cagcttctttacctgagcctggggtgttctacttctaaattatcatggaccagcccttct 600 gtgctactgctattagttgggagtgtaataatcctcttactgttcatattgcacgaaagg 660 aaaacaagtgctagagcgattattcctatggagctggtcaattcctcctacagtgtcgtt 720 gtactttcgataagtatacttgttggttttgccagctacgcgtatctttttactttacca 780 ttattctttcagattgtacttggagattccactgcaaaagcaggattacgtcttacgatt 840 ccttccctatttactccggtaggcagtctcataacaggattttccatgagcaagtacaac 900 tgtctaagattattactctacattggtatttctttgatgtttttgggtaactttttattc 960 ctgtttattgaaaaaacttctccgaactggttgattggtctatttttgatacctgcaaat 1020 ctaggacaaggtatcacttttcctacgaccttgtttactttcatatttatgttctctaag 1080 agtgaccaagctactgcgacatcaactttatatttattccgtagtattggatctgtatgg 1140 ggtgttgcaatttcagctggcgtcattcaattatctttcgcaggtttattgcgtagtaat 1200 ttgaaaggtctactggatgaaaacaagataaagaaacttattgttcagcttagtgcaaac 1260 tcctcatatattggatctttacatggcgaagttaaaaacacagtcataaagagttttgat 1320 gaggcaacaaagagggctcatctaatgtctacattactctcttcattggccctgatactc 1380 tgcatccttaaagacaatctggcgaaacctaaaacaagaagataa 1425 SEQIDNO:70 MSISNWITTAYLITSTSFQPLYGSFSDALGRRNCLFFANGAFTIGCLACGFSKNIYMLSF 60 MRALTGIGGGGLITLSTIVNSDVIPSSKRGIFQAFQNLLLGFGAICGASFGGTIASSIGW 120 RWCFLIQVPISVISSILMNYYVPNQKEYNRQNSSIFQNPGKILRDIDVMGSILIITGLTL 180 QLLYLSLGCSTSKLSWTSPSVLLLLVGSVIILLLFILHERKTSARAIIPMELVNSSYSVV 240 VLSISILVGFASYAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPVGSLITGFSMSKYN 300 CLRLLLYIGISLMFLGNFLFLFIEKTSPNWLIGLFLIPANLGQGITFPTTLFTFIFMFSK 360 SDQATATSTLYLFRSIGSVWGVAISAGVIQLSFAGLLRSNLKGLLDENKIKKLIVQLSAN 420 SSYIGSLHGEVKNTVIKSFDEATKRAHLMSTLLSSLALILCILKDNLAKPKTRR 474 SEQIDNO:71 atgaagggattatcctcattaataaacagaaaaaaagacaggaacgactcacacttagat 60 gagatcgagaatggcgtgaacgctaccgaattcaactcgatagagatggaggagcaaggt 120 aagaaaagtgattttgatctttcccatcttgagtacggtccaggttcactaataccaaac 180 gataataatgaagaagtccccgaccttctcgatgaagctatgcaggacgccaaagaggca 240 gatgaaagtgagaggggaatgccactcatgacagctttgaagacatatccaaaagctgct 300 gcttggtcactattagtttccacaacattgattcaagagggttatgacacagccattcta 360 ggagctttctatgccctgcctgtttttcaaaaaaaatatggttctttgaatagcaataca 420 ggagattatgaaatttcagtttcctggcaaatcggtctatgtctatgctacatggcaggt 480 gagattgtcggtttgcaaatgactgggccttctgtagattacatgggcaaccgttacact 540 ctgatcatggcgttgttctttttagcggctttcattttcattctgtatttttgcaagagt 600 ttgggtatgattgccgtgggacaggcattgtgtggtatgccatggggttgtttccaatgt 660 ttgaccgtttcttatgcttctgaaatttgtcctttggccctaagatactatttgacgact 720 tattctaatttatgttgggcgttcggtcaacttttcgctgctggtattatgaaaaattcc 780 cagaacaaatatgccaactcagaactaggatataagctaccttttgctttgcagtggatc 840 tggccccttcctttggcggtaggtattttttttgcaccagagtctccatggtggctggtt 900 aaaaaaggaaggattgatcaagcgaggagatcacttgaaagaacattaagtggtaaagga 960 cccgagaaagaattactagtgagtatggaactcgataaaatcaaaactactatagaaaag 1020 gagcagaaaatgtctgatgaaggaacttactgggattgtgtgaaagatggtattaacagg 1080 agaagaacgagaatagcttgtttatgttggatcggtcaatgctcctgtggtgcatcatta 1140 attggttattcaacttacttttatgaaaaagctggtgttagcactgatacggcttttact 1200 ttcagtattatccaatattgtcttggtattgctgcaacgtttatatcctggtgggcttca 1260 aaatattgtggcagatttgacctttatgcttttgggctggcttttcaggctattatgttc 1320 ttcattatcggtggtttaggatgttcagacactcatggcgctaaaatgggtagtggtgct 1380 cttctaatggttgtcgcgttcttttacaacctcggtattgcacctgttgttttttgctta 1440 gtgtctgaaataccgtcttcaaggctaagaaccaaaacaattattttggctcgtaatgct 1500 tacaatgtgatccaagttgtagttacagttttgatcatgtaccaattgaactcagagaaa 1560 tggaattggggtgctaaatcaggctttttctggggaggattttgtctggccactttagct 1620 tgggctgttgtcgatttaccagaaaccgctggcaggacttttattgagataaatgaattg 1680 tttagacttggtgttccagcaagaaagttcaagtcgactaaagtcgacccttttgcagct 1740 gccaaagcagcagctgcagaaattaatgttaaagatccgaaggaagatttggaaacttct 1800 gtggtagatgaagggcgaaacacctcatctgttgtgaacaaatga 1845 SEQIDNO:72 MKGLSSLINRKKDRNDSHLDEIENGVNATEFNSIEMEEQGKKSDFDLSHLEYGPGSLIPN 60 DNNEEVPDLLDEAMQDAKEADESERGMPLMTALKTYPKAAAWSLLVSTTLIQEGYDTAIL 120 GAFYALPVFQKKYGSLNSNTGDYEISVSWQIGLCLCYMAGEIVGLQMTGPSVDYMGNRYT 180 LIMALFFLAAFIFILYFCKSLGMIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTT 240 YSNLCWAFGQLFAAGIMKNSQNKYANSELGYKLPFALQWIWPLPLAVGIFFAPESPWWLV 300 KKGRIDQARRSLERTLSGKGPEKELLVSMELDKIKTTIEKEQKMSDEGTYWDCVKDGINR 360 RRTRIACLCWIGQCSCGASLIGYSTYFYEKAGVSTDTAFTFSIIQYCLGIAATFISWWAS 420 KYCGRFDLYAFGLAFQAIMFFIIGGLGCSDTHGAKMGSGALLMVVAFFYNLGIAPVVFCL 480 VSEIPSSRLRTKTIILARNAYNVIQVVVTVLIMYQLNSEKWNWGAKSGFFWGGFCLATLA 540 WAVVDLPETAGRTFIEINELFRLGVPARKFKSTKVDPFAAAKAAAAEINVKDPKEDLETS 600 VVDEGRNTSSVVNK 614 SEQIDNO:73 atgggaagtcatcgacgttatctctactatagtatattatcatttctattattatcctgc 60 tcagtggtacttgcaaaacaagataagaccccattctttgaaggtacttcttcgaaaaat 120 tcgcgtctaactgcacaagataagggcaatgatacatgcccgccatgttttaattgtatg 180 ctacctatttttgaatgcaaacagttttctgaatgcaattcgtacactggtagatgtgag 240 tgtatagaagggtttgcaggtgatgattgctctctgcccctctgtggcggtctatcaccg 300 gatgaaagcggtaataaggatcgtcccataagagcacaaaatgacacctgtcattgtgat 360 aacggatggggagggatcaattgtgacgtttgtcaagaagattttgtctgtgatgcgttc 420 atgcctgatcctagtattaaggggacatgttataagaatggtatgattgtagataaagta 480 ttttcaggttgtaatgtgaccaatgagaaaattctacagattttgaacggcaaaatacca 540 caaattacatttgcctgtgataaacctaatcaagaatgtaattttcagttttggatagat 600 cagttagaaagcttctattgtggcttaagtgattgtgcctttgaatacgacttggaacag 660 aatacctcccattataagtgtaatgacgttcaatgcaaatgcgttcccgacactgtgttg 720 tgtggtgctaaggggtctatagatatctcggatttcctgacagagacaataaaagggcca 780 ggagatttcagctgtgatttagaaacaaggcaatgtaaattcagtgagccttctatgaat 840 gatttgatattgaccgtgtttggtgacccttatattactttgaagtgtgaatccggtgaa 900 tgtgttcattatagtgagattccaggttacaaatctccttcaaaagatccaacagtgtca 960 tggcaagggaaattggtgttggcattgactgctgtgatggtcctggcactttttacattt 1020 gctaccttttacatttctaaatctccgttattcagaaatggattgggttcctcaaagtct 1080 cccattcgtttgccagatgaagatgcggtgaataatttcttacaaaatgaagatgacaca 1140 ctggcgacattaagttttgaaaatatcacttatagtgtcccctcgataaattcagatggt 1200 gttgaagaaactgtgctgaatgaaataagtggtatcgtgaagcccggccaaatattagct 1260 atcatgggtggatctggtgcgggtaaaactactttattagatatcctagcaatgaaacgg 1320 aaaacaggtcacgtttcgggttccataaaagttaacggtattagtatggaccgtaaatct 1380 ttctcgaaaataatcgggttcgtcgatcaagatgactttttgctgcccactttgactgtt 1440 tttgaaaccgtattaaatagtgcgctgttaagattgccaaaagcattgtcattcgaggcc 1500 aagaaggcaagagtttataaggtgttggaagaactaagaattattgatatcaaagatcgt 1560 attattggtaatgaatttgatcgtggtattagtggaggtgaaaaacgccgagtttccatt 1620 gcatgtgaattagtgacatctccattggttttatttttggatgaacctacatctggttta 1680 gatgctagtaatgccaataatgttattgaatgtttggtaaggttatccagcgactataac 1740 aggacattggtgctatctattcatcagccaagatcaaatatattttatttattcgataaa 1800 ttggtcctgttaagtaaaggtgagatggtctattccggaaatgccaaaaaagtgtcagaa 1860 tttttgagaaatgagggatatatctgtccggacaactataatattgctgattatttgatt 1920 gatattacttttgaagccggtcctcaggggaaaaggagaagaatcagaaacatttccgat 1980 ttagaagctggtacggatactaacgatattgataatacgatacaccaaacaacatttact 2040 agcagtgatggtacaacacagagagagtgggctcatcttgcagctcatagagatgagatc 2100 agatctttactcagagatgaagaagatgtagagggaacagatggaaggcgaggtgctact 2160 gagattgacttaaataccaaactactacacgataaatataaagatagcgtctattatgca 2220 gagctttcacaggagatcgaggaagttttaagcgaaggtgatgaggaaagtaacgttttg 2280 aatggagatttacccacaggtcaacaatctgctggttttctgcaacagttatcgatattg 2340 aattcaagaagttttaaaaacatgtacagaaaccctaaactattattgggtaattattta 2400 ctgacgatcctattgagtttattcttgggaacactatattacaacgtctccaatgatatc 2460 agcggttttcagaacagaatggggctgttcttctttatactaacgtacttcggttttgtt 2520 acattcacaggtctcagctcgttcgctctggaaaggatcattttcataaaagaaagatcc 2580 aataactattactcgccacttgcatactacattagtaagataatgagcgaagtggtcccg 2640 ctacgtgttgtaccacctatactcttgtcattgattgtttacccaatgactggtttaaac 2700 atgaaagacaatgctttttttaaatgtattggaatccttatactgtttaaccttgggata 2760 tcgttggaaatcctaaccatcggcataatttttgaagacttgaataactccataatatta 2820 agcgtgctggtgcttttgggctcactactgtttagcggactatttatcaatactaagaat 2880 attacaaacgtggccttcaagtacctgaaaaacttctctgtgttttactacgcctacgaa 2940 tctttattgatcaatgaggtcaaaacattgatgctgaaagagagaaagtacggcttaaat 3000 attgaagttccaggcgctactatcttgagcacatttggatttgttgtccaaaaccttgta 3060 tttgacatcaagatcctggctctgtttaatgtggtgtttttaataatggggtatctagcc 3120 cttaagtggatagttgtggaacaaaagtag 3150 SEQIDNO:74 MGSHRRYLYYSILSFLLLSCSVVLAKQDKTPFFEGTSSKNSRLTAQDKGNDTCPPCFNCM 60 LPIFECKQFSECNSYTGRCECIEGFAGDDCSLPLCGGLSPDESGNKDRPIRAQNDTCHCD 120 NGWGGINCDVCQEDFVCDAFMPDPSIKGTCYKNGMIVDKVFSGCNVTNEKILQILNGKIP 180 QITFACDKPNQECNFQFWIDQLESFYCGLSDCAFEYDLEQNTSHYKCNDVQCKCVPDTVL 240 CGAKGSIDISDFLTETIKGPGDFSCDLETRQCKFSEPSMNDLILTVFGDPYITLKCESGE 300 CVHYSEIPGYKSPSKDPTVSWQGKLVLALTAVMVLALFTFATFYISKSPLFRNGLGSSKS 360 PIRLPDEDAVNNFLQNEDDTLATLSFENITYSVPSINSDGVEETVLNEISGIVKPGQILA 420 IMGGSGAGKTTLLDILAMKRKTGHVSGSIKVNGISMDRKSFSKIIGFVDQDDFLLPTLTV 480 FETVLNSALLRLPKALSFEAKKARVYKVLEELRIIDIKDRIIGNEFDRGISGGEKRRVSI 540 ACELVTSPLVLFLDEPTSGLDASNANNVIECLVRLSSDYNRTLVLSIHQPRSNIFYLFDK 600 LVLLSKGEMVYSGNAKKVSEFLRNEGYICPDNYNIADYLIDITFEAGPQGKRRRIRNISD 660 LEAGTDTNDIDNTIHQTTFTSSDGTTQREWAHLAAHRDEIRSLLRDEEDVEGTDGRRGAT 720 EIDLNTKLLHDKYKDSVYYAELSQEIEEVLSEGDEESNVLNGDLPTGQQSAGFLQQLSIL 780 NSRSFKNMYRNPKLLLGNYLLTILLSLFLGTLYYNVSNDISGFQNRMGLFFFILTYFGFV 840 TFTGLSSFALERIIFIKERSNNYYSPLAYYISKIMSEVVPLRVVPPILLSLIVYPMTGLN 900 MKDNAFFKCIGILILFNLGISLEILTIGIIFEDLNNSIILSVLVLLGSLLFSGLFINTKN 960 ITNVAFKYLKNFSVFYYAYESLLINEVKTLMLKERKYGLNIEVPGATILSTFGFVVQNLV 1020 FDIKILALFNVVFLIMGYLALKWIVVEQK 1049 SEQIDNO:75 atggcgcgtcaaaagcttactttcaaagaacaaatggatggtttcccctgggtccaactt 60 gttgttgtgtccttagttaggttcagcgaaccaattgcgttttcgtcactatttccttat 120 gtttatttcatggttagagattttaatattgctcccaatgatgctcaagtgtccaaatat 180 tcaggttatttatcttcatcatttgcgttatgccaagtcatatctgcgtaccactggggt 240 agattctctgaaaagcatggcagaaaaataacattgacttgcgggcttataggaacatct 300 gtatcattgttaatactgggattttcacgcaatttctatcaggctttggtggcaagaagt 360 ttaatgggattgctaaatggtaacgtcggcgttattagaaccattattggtgaaatagca 420 actgaaagaaaacatcaggctttagctttcagtactatgcctttattatttcaatttggt 480 gccgttgttgggcctatgatcggtgggtttcttgtatttagagatggaacaatgaatgaa 540 gtgccactatggtttccacattttgcaaaaagaataattaggtcatatccgtacgccttg 600 ccaaacgtggtagtgtgcatgtttttgatgtttggtttaactaatgcaacattgtttttg 660 gaagaaacacatcctgcttttaaagatagaagagattacggtttagaggtcggtgatttt 720 attaagaagaatatatttggtatacagccgaaaagaagaccctggcaaaagcgcattcag 780 gatgattcggaaaacattcaccaccgtaatgagaatgtgaacagcattcgaggacaagat 840 agtgaagaggatgaaaatagtcccctagtgaatactaccaatgacgatgatactgaaagc 900 atacaatcgattgatcctattttaacaagaagacagtctgtaggcctgattaggacatat 960 tctctgcatgaaccaacagacgctgtgcatgccaatatagatacagctccagacggttgt 1020 aaagaaagtagtatatttcatcacgtttttcatacaaaagtattttaccctatatcggtg 1080 aattttattatggctttacatttgattgtatacaacgaatttttgcctgtttttttagct 1140 tatgatttagccgtagatccagaaaatccaaagaagctggcttcaaaatttccgtggaaa 1200 atatctggcggtataggttatgaaccagaacaaaccggtactcttttgtcgacaacaggt 1260 atctttggttgttttgtggttattttcatttttcccatagttgatcgaaatttcgattgt 1320 ttaacaattttcagaactttagtcaagctgtaccctattatgtacgttatggttccttac 1380 gttgtttttctacagaatgaacggattcctagctggtatactgtcgtctacttgtacata 1440 atcacagggataaaaacattttgtggcgctttaacgtcaccacaaattatgttattaatt 1500 cataattcgagtcccttgagttgtagatcagtcatcaatggcgccaccattagtatttct 1560 gcctctgctcgtttcataggtcccttagtatggggctatattatgtcttggtcccagcaa 1620 aatgacgtcgcctgggtcagttggtggtcgttaagtcttttttgtatggtagctctttat 1680 caaagttataagatagcaccaattgatgataacgaaaatgagcttcatggacagggtagt 1740 gaagatgcctacaattcgcagtcacagtcttctgatttaagaatggctcatcgatctagt 1800 ttaagcagcttaagtaaccaacgctgtaccacatga 1836 SEQIDNO:76 MARQKLTFKEQMDGFPWVQLVVVSLVRFSEPIAFSSLFPYVYFMVRDFNIAPNDAQVSKY 60 SGYLSSSFALCQVISAYHWGRFSEKHGRKITLTCGLIGTSVSLLILGFSRNFYQALVARS 120 LMGLLNGNVGVIRTIIGEIATERKHQALAFSTMPLLFQFGAVVGPMIGGFLVFRDGTMNE 180 VPLWFPHFAKRIIRSYPYALPNVVVCMFLMFGLTNATLFLEETHPAFKDRRDYGLEVGDF 240 IKKNIFGIQPKRRPWQKRIQDDSENIHHRNENVNSIRGQDSEEDENSPLVNTTNDDDTES 300 IQSIDPILTRRQSVGLIRTYSLHEPTDAVHANIDTAPDGCKESSIFHHVFHTKVFYPISV 360 NFIMALHLIVYNEFLPVFLAYDLAVDPENPKKLASKFPWKISGGIGYEPEQTGTLLSTTG 420 IFGCFVVIFIFPIVDRNFDCLTIFRTLVKLYPIMYVMVPYVVFLQNERIPSWYTVVYLYI 480 ITGIKTFCGALTSPQIMLLIHNSSPLSCRSVINGATISISASARFIGPLVWGYIMSWSQQ 540 NDVAWVSWWSLSLFCMVALYQSYKIAPIDDNENELHGQGSEDAYNSQSQSSDLRMAHRSS 600 LSSLSNQRCTT 611 SEQIDNO:77 atggatttaaccgtggaacctaatttgcactctttaattacctctaccactcataagtgg 60 attttcgttggtggtaaaggtggtgttggtaagactacttcatcatgttccattgctatc 120 caaatggctttgagtcaaccaaacaaacagttcctactgatctctactgatcctgcccat 180 aacttaagtgatgcattcggtgagaaatttggtaaagacgccagaaaggtgacaggcatg 240 aataatctatcatgtatggaaatcgatccatccgctgctttgaaggatatgaacgacatg 300 gcagtttcacgcgctaacaataacggaagtgacggtcaaggtgacgatctaggaagcttg 360 cttcaaggtggtgctcttgctgatttgaccggttccatccctggtatcgacgaagcttta 420 tccttcatggaagtcatgaagcacattaaaaggcaagaacagggcgaaggtgaaaccttc 480 gatactgttatttttgacactgctccaactggccacacattaagatttctacaactacca 540 aatactttatccaagcttttggaaaagttcggtgaaattaccaacaaattgggcccaatg 600 ctaaactcttttatgggcgcaggtaatgtcgatatctctggaaaattgaacgagttaaag 660 gctaatgtcgagaccatcagacaacaattcacggatcctgacctaacgacttttgtttgc 720 gtttgtatcagtgaattcttatccttatatgaaactgaaagactaattcaggaattgatt 780 tcctacgatatggacgttaattccatcattgtcaaccaattattatttgctgaaaacgat 840 caagagcacaactgtaagagatgtcaggcaagatggaagatgcaaaagaagtacttggac 900 caaatcgacgaattgtacgaagatttccatgtcgttaaaatgccattatgtgctggagaa 960 atcagaggcttaaataacttaacaaagttctcacagttcctaaacaaagaatataaccct 1020 attactgatggcaaagtcatttatgagttagaagataaggaatag 1065 SEQIDNO:78 MDLTVEPNLHSLITSTTHKWIFVGGKGGVGKTTSSCSIAIQMALSQPNKQFLLISTDPAH 60 NLSDAFGEKFGKDARKVTGMNNLSCMEIDPSAALKDMNDMAVSRANNNGSDGQGDDLGSL 120 LQGGALADLTGSIPGIDEALSFMEVMKHIKRQEQGEGETFDTVIFDTAPTGHTLRFLQLP 180 NTLSKLLEKFGEITNKLGPMLNSFMGAGNVDISGKLNELKANVETIRQQFTDPDLTTFVC 240 VCISEFLSLYETERLIQELISYDMDVNSIIVNQLLFAENDQEHNCKRCQARWKMQKKYLD 300 QIDELYEDFHVVKMPLCAGEIRGLNNLTKFSQFLNKEYNPITDGKVIYELEDKE 354 SEQIDNO:79 atgactgagcaagcaactaagccaagaaattcatcgcatttgatcgggggctttttcggt 60 gggctaacatctgctgttgcgttgcaacctttagaccttttgaagacgagaatccagcaa 120 gacaagaaagctacattatggaaaaatttgaaagagatagacagccctctacagctatgg 180 agaggtacattaccttcagcattacgaacatcaataggcagcgccttatatttatcatgt 240 ttgaaccttatgcgctcatctttggcaaagaggaggaatgctgtgccttcattaacaaac 300 gattcaaacattgtatataacaagagcagtagcttaccacgattaacgatgtatgaaaat 360 ttactaacaggtgcatttgcaagaggtttggtaggttatataaccatgcctatcaccgtc 420 attaaagtccgttatgagtctactctgtacaattactccagtttaaaggaggcaattacc 480 catatatatactaaggaaggactttttggatttttcagagggtttggagctacttgttta 540 agagacgctccctatgcaggtttgtatgtgctgctatatgaaaaatcgaaacaattactg 600 cccatggtattaccttctaggtttatacattacaatcctgagggaggatttactacttat 660 acctctacaacagtaaatacaacaagcgccgtactatccgccagtttagccaccacagta 720 acggcaccgttcgacaccataaaaacgagaatgcaattggaaccatcaaaatttaccaac 780 tccttcaatacatttacatctatagttaaaaatgaaaatgtgctgaagttatttagcggg 840 ttaagcatgaggctggcaagaaaggccttcagtgcaggtattgcgtggggtatatatgag 900 gagttggtcaaaagattcatgtaa 924 SEQIDNO:80 MTEQATKPRNSSHLIGGFFGGLTSAVALQPLDLLKTRIQQDKKATLWKNLKEIDSPLQLW 60 RGTLPSALRTSIGSALYLSCLNLMRSSLAKRRNAVPSLTNDSNIVYNKSSSLPRLTMYEN 120 LLTGAFARGLVGYITMPITVIKVRYESTLYNYSSLKEAITHIYTKEGLFGFFRGFGATCL 180 RDAPYAGLYVLLYEKSKQLLPMVLPSRFIHYNPEGGFTTYTSTTVNTTSAVLSASLATTV 240 TAPFDTIKTRMQLEPSKFTNSFNTFTSIVKNENVLKLFSGLSMRLARKAFSAGIAWGIYE 300 ELVKRFM 307 SEQIDNO:81 atgaacgatagccaaaactgcctacgacagagggaagaaaatagtcatctgaatcctgga 60 aatgacttcggccaccaccagggtgcagaatgtacgataaatcataacaacatgccacac 120 cgcaatgcatacacagaatctacgaatgacacggaagcaaagtccatagtgatgtgcgac 180 gatcctaacgcataccaaatttcctacacaaataatgagccggcgggagatggagctata 240 gaaaccacgtccattctactatcgcaaccgctgccgctgcgatcgaatgtgatgtctgtc 300 ttggtaggcatatttgttgccgtggggggcttcttgtttgggtatgacactggacttata 360 aacagtatcacggatatgccgtatgttaaaacctacattgctccgaaccattcatatttc 420 accactagccaaatagccatactcgtatcattcctctccctaggaacatttttcggtgcg 480 ttaatcgctccctatatttcagattcatatggtaggaagccaacaattatgtttagtacc 540 gctgttatcttttccatcggaaactcattacaggtggcatccggtggcttggtgctatta 600 atcgtcggaagagtgatctcaggtatcgggatcgggataatctctgctgtggttcctctt 660 tatcaagctgaagctgcgcagaagaaccttagaggtgccatcatttccagttatcagtgg 720 gctatcactattgggttactcgtgtccagtgcagtatcgcaaggaactcattccaaaaat 780 ggcccgtcttcatatagaataccaattggtttgcagtacgtttggtcaagtattttagct 840 gtgggcatgatattccttccagagagtccaagatattacgtcttgaaggatgaactcaat 900 aaagctgcaaaatcgttatcctttttaagaggcctcccgatcgaagatccaagactctta 960 gaggagcttgttgaaataaaagccacttacgattatgaagcatcgttcggcccgtcaaca 1020 cttttagattgtttcaaaacaagtgaaaatagacccaaacagattttacgaatatttact 1080 ggtatcgccatacaagcttttcaacaggcatctggtatcaattttatattctactatgga 1140 gttaattttttcaacaacacaggggtggacaactcttacttggtttcttttatcagctat 1200 gccgtcaacgtcgccttcagtataccgggtatgtatttagtggatcgaattggtagaaga 1260 ccagtccttcttgctggaggtgtcataatggcaatagcaaatttagtcattgccatcgtt 1320 ggtgtttccgagggaaaaactgttgttgctagtaaaattatgattgcttttatatgcctt 1380 ttcattgctgcattttcggcgacatggggtggtgtcgtgtgggtggtatctgctgaactg 1440 tacccacttggtgtcagatcgaaatgtaccgccatatgcgctgccgcaaattggctagtt 1500 aatttcacctgtgccctgattacaccttacattgttgatgtcggatcacacacttcttca 1560 atggggcccaaaatattcttcatttggggcggcttaaatgtcgtggccgttatcgttgtt 1620 tatttcgctgtttatgaaacgaggggattgactttggaagagattgacgagttatttaga 1680 aaggccccaaatagcgtcatttctagcaaatggaacaaaaaaataaggaaaaggtgctta 1740 gcctttcccatttcacaacaaatagagatgaaaactaatatcaagaacgctggaaagttg 1800 gacaacaacaacagtccaattgtacaggatgacagccacaacataatcgatgtggatgga 1860 ttcttggagaaccaaatacagtccaatgatcatatgattgcggcggataaaggaagtggc 1920 tcgttagtaaacatcatcgatactgcccccctaacatctacagagtttaaacccgtggaa 1980 catccgccagtaaattacgtcgacttggggaatggtttgggtctgaatacatacaataga 2040 ggtcctccttctatcatttctgactctactgatgagttctatgaggaaaatgactcttct 2100 tattacaataacaacactgaacgaaatggagctaacagcgtcaatacatatatggctcaa 2160 ctaatcaatagctcatctactacaagcaacgacacatcgttctctccatcacacaatagc 2220 aatgcaagaacgtcctctaattggacgagtgacctcgctagtaagcacagccaatacact 2280 tccccccaataa 2292 SEQIDNO:82 MNDSQNCLRQREENSHLNPGNDFGHHQGAECTINHNNMPHRNAYTESTNDTEAKSIVMCD 60 DPNAYQISYTNNEPAGDGAIETTSILLSQPLPLRSNVMSVLVGIFVAVGGFLFGYDTGLI 120 NSITDMPYVKTYIAPNHSYFTTSQIAILVSFLSLGTFFGALIAPYISDSYGRKPTIMFST 180 AVIFSIGNSLQVASGGLVLLIVGRVISGIGIGIISAVVPLYQAEAAQKNLRGAIISSYQW 240 AITIGLLVSSAVSQGTHSKNGPSSYRIPIGLQYVWSSILAVGMIFLPESPRYYVLKDELN 300 KAAKSLSFLRGLPIEDPRLLEELVEIKATYDYEASFGPSTLLDCFKTSENRPKQILRIFT 360 GIAIQAFQQASGINFIFYYGVNFFNNTGVDNSYLVSFISYAVNVAFSIPGMYLVDRIGRR 420 PVLLAGGVIMAIANLVIAIVGVSEGKTVVASKIMIAFICLFIAAFSATWGGVVWVVSAEL 480 YPLGVRSKCTAICAAANWLVNFTCALITPYIVDVGSHTSSMGPKIFFIWGGLNVVAVIVV 540 YFAVYETRGLTLEEIDELFRKAPNSVISSKWNKKIRKRCLAFPISQQIEMKTNIKNAGKL 600 DNNNSPIVQDDSHNIIDVDGFLENQIQSNDHMIAADKGSGSLVNIIDTAPLTSTEFKPVE 660 HPPVNYVDLGNGLGLNTYNRGPPSIISDSTDEFYEENDSSYYNNNTERNGANSVNTYMAQ 720 LINSSSTTSNDTSFSPSHNSNARTSSNWTSDLASKHSQYTSPQ 763 SEQIDNO:83 atgaaacctccgttaaacatgtcacgttcaaataaaccacttactcaggaagctaatagt 60 tcggcgcatattgatagggcacatcagctagcacaggattttaacagtaaacaggatgat 120 accgcactaacttcactgccccacaagaaccccgacatattcagatttgagaacaacatc 180 acagctcatagctcgcgtcgtggttctctatatagagacagcgatgctactgtggttttg 240 ccgctttctgaacatacccctagattatcaatggatgatccataccgccaattactacaa 300 caggctgaaatctcacaactacgaagtaagaaaaaaaggcattccagtcgagttttgcgt 360 acttcgtttatatcttttgtggtgctagtttcctcgctgtcagggttggaccaaggcctc 420 atatctggtaacgttatgactttgtcgttccagaagtattttcattacccacttacttct 480 ccgctgggcaatatagtgagcattgttaatctgggtgcgttcatggcgtcgttatttgtc 540 tattctggcatcctggagccttgtagcaggaaaaaaatgctccaaataagcacaatgata 600 tactctttgggtgccattgttcaggtcttggctctaaaccaatggtgtttactactgggt 660 agattcttactcggagtaggtatgggctttgccttttctatggtaataatttatcaattc 720 gagtttccccttccctgtataagaaaacggacattaatttccattcaatgcgtctctagt 780 gtcattgcgtattcattcggaatatggattaattgtgctttcagatatttgggctttgca 840 tggagataccctttgtcaacacatgtggcacttggaataatactaaacctaatgtcgttc 900 tatcttattttagagtccccttcgtggctgttgaagcaaaagaacgacgtagaggcattg 960 gttttaatatcgaatgttttcgatgatggaaatttcgaagaaaaccaaactcagttgaaa 1020 tttagggtcctgaaacgagacatattattaaagtcacaccttcaaaaaaactcctatcca 1080 tatgcgtatatcttaaaggatttttcttcaataataaaattgttgataggtttccaactt 1140 ctcacacgaacaaatggagtggatgctttcttgtattactcaccgttaatattacaacaa 1200 atggggagaggagaaagaaaatctatctatttaacggggcttaatgctttaatttacagc 1260 atcgtaatattagcatatgttcccttggtgttacggaaacgtaaagagaaaacgaatgta 1320 ctcttaggttcgattgtgatgtgtgcattgctatttaccatatcttttacagactggttt 1380 cccaagagcacaacgaggtatatatcaatactatttgctgtttttctttttacgcacttc 1440 atcagttgggattctataggatgggttatgaccattgagcttctacctcacttgtcacag 1500 gccccagtgatactactagtctcaaacttttattggatttttaagtggttcgtcagctta 1560 ataacccctatacttattgaccgtctgtcttggaagttttatcttattccatctttatct 1620 tcctttatttccattatatttgtgctgaagatttttcctatagaaacccgtgacgaaagg 1680 ttagattctgatgatgattctaccggaaacggtagcggtaaccatgatgatgtttttgac 1740 gataccggttctgaattctcctcctcaccatctttttccgcgtatcagataaacactcta 1800 ggaagtagtatcaaacaaaataatcaagcctattcatctattcaaaatgagcagattcta 1860 cccaaaaacggaaacttatcgaaccagacacacggttctgcacaaaatgtttatttcatt 1920 acatctgattcaggaccatcaaggactggagaatttttcagttttcataacagaaccgat 1980 ccaaatatcagcgacaacattgctgcgaataaacccagttcaggtggaggccagaattcg 2040 cctggagacatggcagttgcctag 2064 SEQIDNO:84 MKPPLNMSRSNKPLTQEANSSAHIDRAHQLAQDFNSKQDDTALTSLPHKNPDIFRFENNI 60 TAHSSRRGSLYRDSDATVVLPLSEHTPRLSMDDPYRQLLQQAEISQLRSKKKRHSSRVLR 120 TSFISFVVLVSSLSGLDQGLISGNVMTLSFQKYFHYPLTSPLGNIVSIVNLGAFMASLFV 180 YSGILEPCSRKKMLQISTMIYSLGAIVQVLALNQWCLLLGRFLLGVGMGFAFSMVIIYQF 240 EFPLPCIRKRTLISIQCVSSVIAYSFGIWINCAFRYLGFAWRYPLSTHVALGIILNLMSF 300 YLILESPSWLLKQKNDVEALVLISNVFDDGNFEENQTQLKFRVLKRDILLKSHLQKNSYP 360 YAYILKDFSSIIKLLIGFQLLTRTNGVDAFLYYSPLILQQMGRGERKSIYLTGLNALIYS 420 IVILAYVPLVLRKRKEKTNVLLGSIVMCALLFTISFTDWFPKSTTRYISILFAVFLFTHF 480 ISWDSIGWVMTIELLPHLSQAPVILLVSNFYWIFKWFVSLITPILIDRLSWKFYLIPSLS 540 SFISIIFVLKIFPIETRDERLDSDDDSTGNGSGNHDDVFDDTGSEFSSSPSFSAYQINTL 600 GSSIKQNNQAYSSIQNEQILPKNGNLSNQTHGSAQNVYFITSDSGPSRTGEFFSFHNRTD 660 PNISDNIAANKPSSGGGQNSPGDMAVA 687 SEQIDNO:85 atgagtatgtcaagcaaaaacgagaataagatatcagtagaacaaagaatatccactgat 60 atcggtcaggcttaccagttacaaggccttgggtctaacctaaggtcgattcgctccaag 120 actggtgccggtgaagtgaactatatcgatgctgctaaatctgtaaatgataaccaactg 180 cttgcagagatcggttataaacaagaattaaaaagacaattttcaacattacaagttttc 240 ggtattgcgttctccattatgggtctattgccctccattgcatctgtgatgggtggtggg 300 ctcggtggtggtccagcaacattagtgtggggttggttcgttgctgcgtttttcatttta 360 ctggtgggtattaccatggctgaacatgcaagttccattcctaccgctggtggtttgtac 420 tactggacgtattactatgctccagaaggttataaagagattatttcttttattattggt 480 tgctcaaactccctagcgttggcagccggtgtgtgttccattgattacggtttggctgag 540 gaaattgctgctgctgtcacattaaccaaagatggaaattttgaagtaacgagtgggaaa 600 ctttacggtatatttgctggagcagtggtggttatgtgtatttgtacatgtgttgcttct 660 ggggccattgctcgtctgcagacgctaagtatatttgccaatcttttcattattgtttta 720 ttgttcattgcgctaccgattggtaccaagcatagaatgggaggtttcaatgatggtgac 780 tttatatttgggaaatatgaaaacttaagtgactggaataatggttggcaattttgtctt 840 gctggtttcatgcctgctgtctggactattggttcctttgattcatgtgtccatcaatct 900 gaagaagccaaagatgccaagaaatcagtccccattggtataatctcatctattgctgtt 960 tgttggattttaggttggttgattattatttgtttaatggcctgtatcaaccctgatatt 1020 gacagcgttttggactccaagtacggctttgctttggctcaaataatttatgattcgtta 1080 ggaaaaaaatgggccattgcatttatgtcattgatcgcattctgtcaatttctaatgggt 1140 gcttccattaccacagctgtttctagacaagtttgggcattttcccgtgataacggtttg 1200 cccctatcaaagtatattaaaagagtggattctaaatactcggtcccttttttcgctatt 1260 ttggctgcctgtgtaggttccttgattttaggattgttatgtttgattgatgatgccgcc 1320 actgatgcattatttagtctggctgttgcaggaaacaatttggcatggagtacccctaca 1380 gttttccgtttaacatcaggtagagatttatttagacctggtccattttatttgggtaaa 1440 atctggtctccaattgttgcttggacaggtgttgctttccaattgttcattattattttg 1500 gttatgttcccctctcaacaacatggtattactaaatccacaatgaattatgcatgcgtt 1560 attggtcccggtatctggatccttgcaggtatctactacaaagtttacaagaagaaatac 1620 taccacggtccagcaaccaatttgtcggatgatgattatactgaagccgttggtgctgat 1680 gttatcgacacaattatgtccaaacaggaaccataa 1716 SEQIDNO:86 MSMSSKNENKISVEQRISTDIGQAYQLQGLGSNLRSIRSKTGAGEVNYIDAAKSVNDNQL 60 LAEIGYKQELKRQFSTLQVFGIAFSIMGLLPSIASVMGGGLGGGPATLVWGWFVAAFFIL 120 LVGITMAEHASSIPTAGGLYYWTYYYAPEGYKEIISFIIGCSNSLALAAGVCSIDYGLAE 180 EIAAAVTLTKDGNFEVTSGKLYGIFAGAVVVMCICTCVASGAIARLQTLSIFANLFIIVL 240 LFIALPIGTKHRMGGFNDGDFIFGKYENLSDWNNGWQFCLAGFMPAVWTIGSFDSCVHQS 300 EEAKDAKKSVPIGIISSIAVCWILGWLIIICLMACINPDIDSVLDSKYGFALAQIIYDSL 360 GKKWAIAFMSLIAFCQFLMGASITTAVSRQVWAFSRDNGLPLSKYIKRVDSKYSVPFFAI 420 LAACVGSLILGLLCLIDDAATDALFSLAVAGNNLAWSTPTVFRLTSGRDLFRPGPFYLGK 480 IWSPIVAWTGVAFQLFIIILVMFPSQQHGITKSTMNYACVIGPGIWILAGIYYKVYKKKY 540 YHGPATNLSDDDYTEAVGADVIDTIMSKQEP 571 SEQIDNO:87 atggcaagcgaacagtcctcaccagaaattaatgcagataatctaaacagtagtgcagct 60 gacgttcatgtacagccacccggagagaaagaatggtcagacgggttttatgacaaagaa 120 gtcattaatggaaatacgccagacgcaccgaagagaggctttttaggttaccttattatc 180 tacttactatgctatcctgtatcctttggcggttttttacctggttgggatagtggtatt 240 actgcaggcttcatcaatatggataactttaaaatgaattttggttcttacaagcacagt 300 actggtgagtattatttgagcaacgtgcgtatgggtcttctcgtggccatgttcagtgta 360 ggatgttccattggcggtgttgcttttgcgagacttgctgatactttaggtagaaggcta 420 gcaattgtaatcgtggttttggtatatatggttggtgcaattattcagatcagttcgaat 480 cacaaatggtaccaatactttgtcggtaagatcatctacggtcttggtgctggtggctgt 540 tcggtgttgtgtccaatgcttttatctgaaatagcccccacagatttgagaggtggactt 600 gtctcattgtaccaacttaacatgaccttcggtattttcttgggttattgtagcgtttat 660 ggaacaaggaagtatagtaatactgcgcaatggaggattcctgtgggactatgctttctg 720 tgggctctaattatcatcgttggcatgttattagttccagagtccccaagatatctgatt 780 gaatgtgagagacatgaagaggcctgtgtctccatcgccaagatcaacaaggtttcacca 840 gaggatccatgggtactcaaacaggctgatgaaatcaacgccggtgtccttgcccaaaga 900 gaactaggggaagcctcatggaaagaacttttctccgtcaaaacaaaagtccttcaacgt 960 ttgatcacaggtattcttgtgcaaacctttttgcaacttactggtgaaaactacttcttc 1020 ttctacggaactaccattttcaaatcagttgggcttactgatgggtttgagacttcgatc 1080 gtcctaggtacagtgaatttcttctccactattattgctgttatggtcgtagacaaaata 1140 ggccgtcgtaaatgtctgttattcggagcggcttcaatgatggcttgtatggtcatattt 1200 gcaagtatcggggtaaaatgtctttaccctcatggccaggatggtccatcctcgaaaggt 1260 gcaggtaatgccatgattgtgttcacatgcttctatatattctgctttgcaacgacatgg 1320 gcccctgttgcttatattgtggttgccgagtcattcccttcgaaggtcaaatctaaagca 1380 atgtcaatttcgactgcattcaactggttatggcaattcttgattggttttttcacacca 1440 ttcattactgggtctatccacttctattatggttatgtgttcgtaggttgtttggttgct 1500 atgtttttgtacgttttcttctttttaccagaaacaattggtctatctttggaggaaatc 1560 cagttactatatgaagaaggtataaaaccatggaaatctgcatcttgggtaccaccctca 1620 aggagaggagcttcttccagggaaactgaggctaagaagaaaagctggaaagaagttttg 1680 aagttcccaaagagttttaattga 1704 SEQIDNO:88 MASEQSSPEINADNLNSSAADVHVQPPGEKEWSDGFYDKEVINGNTPDAPKRGFLGYLII 60 YLLCYPVSFGGFLPGWDSGITAGFINMDNFKMNFGSYKHSTGEYYLSNVRMGLLVAMFSV 120 GCSIGGVAFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGC 180 SVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSVYGTRKYSNTAQWRIPVGLCFL 240 WALIIIVGMLLVPESPRYLIECERHEEACVSIAKINKVSPEDPWVLKQADEINAGVLAQR 300 ELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENYFFFYGTTIFKSVGLTDGFETSI 360 VLGTVNFFSTIIAVMVVDKIGRRKCLLFGAASMMACMVIFASIGVKCLYPHGQDGPSSKG 420 AGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSKAMSISTAFNWLWQFLIGFFTP 480 FITGSIHFYYGYVFVGCLVAMFLYVFFFLPETIGLSLEEIQLLYEEGIKPWKSASWVPPS 540 RRGASSRETEAKKKSWKEVLKFPKSFN 567 SEQIDNO:89 atgagtaccaataagttcgttgtacgaataacgaatgcgctcttcaagtcatcactggct 60 agcaacagtccacctgtttaccctaagaggattaggcatttcgagattttacccaacgaa 120 aaatgggttatatggggacctggaaagggcaagttcttggatgtactgaataacaagtat 180 atttgtgagcccccattatctttgaggtttggatttttgaaggaaagttcgaacatcctg 240 ccgaggatagagcaagtggccttcaaaggggttatgccaacggctcatttaagtgctaga 300 tatgaatacttcaaagatgactacgatcaaacctgcaaacagtttatatttgataaggca 360 agcggatcaaatgctgtttcatataaagttgagacgaacaatcggcaaataaacatggag 420 ctgtacaatgcattagttgaaaatttaaacctctccagtttacaggataggtgggtaatg 480 ggattgagtaatggacaaatgaggagagcaaggttagctcgtagtatactcaaggaaccg 540 gatctactacttattgacgacccatttttagggttggatccagccgcaatagcaaccatt 600 tcacaatttttagccaaatatgatagtatagaagtcagtggcggatgtccaatcgtcatt 660 ggtttgaggtatcaagataccattccagcatggtgtactcatatatgttgcgttgatgag 720 aaaaacggtatattgtttgaaggcccaatcgaaaaacttcaaagtaaaatggatgaaacc 780 agatcaagggcactaaaagaactagagcagctcaaaaaagcgtctaattccaaagaggac 840 atttccattaacgatttgatttgtatacatcctatgtatggcaagaaagagcacgaaatt 900 atcaaaatgcctcatcttatagaattagacgggttgagcgtttcatacaaaggcgaagct 960 gttttggaaaatctgcactggaaagttcagccgggttcgaaatggcatataagaggtgac 1020 aatgggtcaggtaagtcgaccttattatctttgcttacggcggaacatccccaatcgtgg 1080 aattcgagggtgatagataatggcgtcccacgaagaacaggtaaaacaaactactttgac 1140 ctaaacagcaaaataggtatgtcatcacccgaattacacgcaatttttttgaagaatgct 1200 ggaggaaggctaaacattcgggaaagtgttgcaactggctatcatgaggcgtcctccaac 1260 aattacctacccatatggaagcgcttggacaaaaatagccaagaaatagtgaatatgtat 1320 ctgaaatattttggcctggacaaagacgccgatagtgttttatttgaacagttgtccgta 1380 agtgaccagaaactagtcctttttgtcaggtctttaattaagatgccgcaaatattgatt 1440 ctcgatgaggcattttctggaatggaggtagaacctatgatgcgttgtcatgaattttta 1500 gaggagtggcctggaacagtccttgtagtggcacacgttgccgaagagacaccaaaatgt 1560 gcccattacttaaggctcatatctcctggagagtatgaaataggcgatatggaaaattaa 1620 SEQIDNO:90 MSTNKFVVRITNALFKSSLASNSPPVYPKRIRHFEILPNEKWVIWGPGKGKFLDVLNNKY 60 ICEPPLSLRFGFLKESSNILPRIEQVAFKGVMPTAHLSARYEYFKDDYDQTCKQFIFDKA 120 SGSNAVSYKVETNNRQINMELYNALVENLNLSSLQDRWVMGLSNGQMRRARLARSILKEP 180 DLLLIDDPFLGLDPAAIATISQFLAKYDSIEVSGGCPIVIGLRYQDTIPAWCTHICCVDE 240 KNGILFEGPIEKLQSKMDETRSRALKELEQLKKASNSKEDISINDLICIHPMYGKKEHEI 300 IKMPHLIELDGLSVSYKGEAVLENLHWKVQPGSKWHIRGDNGSGKSTLLSLLTAEHPQSW 360 NSRVIDNGVPRRTGKTNYFDLNSKIGMSSPELHAIFLKNAGGRLNIRESVATGYHEASSN 420 NYLPIWKRLDKNSQEIVNMYLKYFGLDKDADSVLFEQLSVSDQKLVLFVRSLIKMPQILI 480 LDEAFSGMEVEPMMRCHEFLEEWPGTVLVVAHVAEETPKCAHYLRLISPGEYEIGDMEN 539 SEQIDNO:91 atggctggtaatcttgtttcatgggcctgcaagctctgtagatctcctgaagggtttgga 60 cctatatccttttacggtgactttactcaatgcttcatcgacggtgtgatcctaaatcta 120 tcagcaattttcatgataaccttcggtatcagagatttagttaacctttgcaagaaaaaa 180 cactctggcatcaaatataggcggaattggattattgtctctaggatggcactagttctg 240 ttggagatagcgtttgtttcacttgcgtctttaaatatttctaaagaagaagcggaaaac 300 tttaccattgtaagtcaatatgcttctacaatgttatctttatttgttgctttagcctta 360 cactggatagaatacgatagatcagttgtagccaatacggtacttttattctattggctt 420 tttgaaacattcggtaattttgctaaactaataaatattctaattagacacacctacgaa 480 ggcatttggtattccggacaaacgggtttcatactaacgttattccaagtaataacatgt 540 gccagtatcctgttacttgaagctcttccaaagaagccgctaatgccacatcaacacata 600 catcaaactttaacaagaagaaaaccaaatccatacgatagcgcaaacatattttccagg 660 attaccttctcttggatgtcaggtttgatgaaaactggctatgaaaaatacttagtggaa 720 gcagatttatataaattaccgaggaactttagtagtgaagaactctctcaaaaattggag 780 aaaaactgggaaaatgagttgaagcaaaaatcaaatccttcattatcatgggctatatgc 840 agaacttttggatctaaaatgcttttagccgcattctttaaagcaattcatgatgttcta 900 gcatttactcaaccacaactactaaggattttaatcaagttcgtcacagactataacagt 960 gagagacaggatgaccattcttctcttcaagggtttgaaaataaccacccacaaaaatta 1020 cccattgtaagagggtttttgattgcgtttgctatgtttctggtgggctttactcagaca 1080 tctgtcctgcatcaatatttcctgaatgtcttcaacacaggcatgtatattaagagcgcc 1140 ctaacggctttaatatatcaaaaatccttagtgctatctaatgaggcttctggactttcc 1200 tctaccggtgacattgtcaatctcatgagtgtggatgttcaaaaattacaagatttaaca 1260 caatggctaaatttaatatggtcagggccttttcaaatcattatttgcttatattctctg 1320 tataagttgttgggaaattccatgtgggttggcgtgattatactagttattatgatgcca 1380 ttgaactcatttttgatgaggatacaaaagaagttgcaaaaatcccagatgaagtacaaa 1440 gatgaaaggacccgtgttataagtgaaatactaaacaatattaaatctttgaagttatat 1500 gcatgggagaagccttatagggaaaagctagaagaagtaagaaataacaaagagttaaaa 1560 aatcttacaaaactaggatgttatatggctgtgacaagttttcagttcaatatagtacca 1620 ttccttgtttcatgttgtacctttgctgtatttgtttatactgaggatagagcattgact 1680 actgacttagttttccctgctttgactctgttcaacctgctctcattcccactaatgatt 1740 attcctatggttttaaattcttttatcgaagcttctgtttctattggtagattatttaca 1800 ttctttaccaatgaagagctacaaccagattcggttcagcgtttaccaaaagtaaaaaat 1860 attggcgatgtagccattaacattggagatgatgctacctttttatggcaacggaaaccg 1920 gaatacaaagtagccttaaagaatattaatttccaagctaaaaaaggaaatttgacctgt 1980 attgttggtaaagttggcagtggtaaaacagctctattgtcatgcatgttaggtgatcta 2040 ttcagggttaaaggtttcgccaccgttcatggttctgttgcttatgtttcacaagttcca 2100 tggataatgaatggtactgtaaaggaaaacattttatttgggcatagatacgacgcggaa 2160 ttttacgaaaaaacgatcaaggcctgtgcgttaactattgatcttgcaattttgatggat 2220 ggagataagacattagttggcgagaaagggatctccttatctggaggacaaaaagctcgt 2280 ttgtctttagcaagagcagtttatgcgagagctgacacttatttacttgatgatcctttg 2340 gcagctgttgatgaacacgttgccaggcacttgatcgaacatgtgttgggtccaaatggt 2400 ttattacatacaaaaacgaaggtattagccactaataaggtgagcgcgttatccatcgca 2460 gattctattgcattattagataatggagaaatcacacagcagggtacatatgatgagatt 2520 acgaaggacgctgattcgccattatggaaattgctcaacaactatggtaaaaaaaataac 2580 ggtaagtcgaatgaattcggtgactcctctgaaagctcagttcgagaaagtagtatacct 2640 gtagaaggagagctggaacaactgcagaaattaaatgatttggattttggcaactctgac 2700 gccataagtttaaggagggccagtgatgcaactttgggaagcatcgattttggtgacgat 2760 gaaaatattgctaaaagagagcatcgtgaacagggaaaagtaaagtggaacatttaccta 2820 gagtacgctaaagcttgcaacccgaaaagcgtttgtgtattcatattgtttattgttata 2880 tcgatgttcctctctgttatgggtaacgtttggttgaaacattggtctgaagttaatagc 2940 cgctatggatctaatccaaatgccgcgcgttacttggccatttattttgcacttggtatt 3000 ggttcagcactggcaacattaatccagacaatcgttctctgggttttttgtaccattcat 3060 gcctccaaatatttacacaacttgatgacaaactctgtgttgagagccccaatgacgttt 3120 tttgaaacaacaccaatcggtagaattctaaacagattctcaaatgacatatacaaagtg 3180 gatgctttattaggaagaacattttctcagtttttcgtcaatgcagtgaaagtcacattc 3240 actattacggttatctgtgcgacgacatggcaatttatcttcattatcattccactaagt 3300 gtgttttacatctactaccagcagtattacctgagaacatcaagggagttgcgtcgttta 3360 gactctattactaggtctccaatctactctcatttccaagagactttgggtggccttgca 3420 acggttagaggttattctcaacagaaaaggttttcccacattaatcaatgccgcattgat 3480 aataacatgagtgcgttctatccctctatcaatgctaaccgttggctagcatataggttg 3540 gaacttattggttcaattatcattctaggtgctgcaactttatccgtttttagactaaaa 3600 caaggcacattaacggcaggtatggtgggtttatcattaagctatgctttacaaatcact 3660 caaacgttaaattggattgttagaatgactgtggaagttgaaacgaatattgtttcagtg 3720 gaaagaataaaggaatatgctgatttgaagagcgaggcacctttaatagttgaaggccac 3780 agaccacccaaagaatggccgagccagggtgatataaagtttaataattattccactcgt 3840 tataggccggagcttgatcttgttctgaagcacattaatatacacattaaaccaaatgaa 3900 aaagttggtatcgtgggtagaacgggtgcgggaaaatcctcattaacgctagcattattc 3960 aggatgattgaggctagcgagggaaacatcgtaatcgacaacattgccatcaacgagatt 4020 gggttatatgatttgagacataaattgtcaatcatacctcaggattctcaagtttttgag 4080 ggcactgttcgtgagaacattgatcccattaaccaatacactgatgaagctatttggagg 4140 gcattggaactttctcatttgaaagaacacgtgctatcaatgagcaatgacggattagat 4200 gcccaactaaccgaaggtggtggcaacttaagtgttggacaaagacaattattatgtctt 4260 gcaagagcaatgttggttccatcaaagattttggtgcttgatgaagccacggccgcagtc 4320 gacgtggagacagataaagtcgtccaagagacgattcgtactgctttcaaggacagaact 4380 atcttgaccatcgcgcatagactgaacacgataatggacagtgatagaatcatagtgttg 4440 gacaatggtaaagtagccgagtttgactctccgggccagttattaagtgataacaaatca 4500 ttgttctattcactgtgcatggaggctggtttggtcaatgaaaattaa 4548 SEQIDNO:92 MAGNLVSWACKLCRSPEGFGPISFYGDFTQCFIDGVILNLSAIFMITFGIRDLVNLCKKK 60 HSGIKYRRNWIIVSRMALVLLEIAFVSLASLNISKEEAENFTIVSQYASTMLSLFVALAL 120 HWIEYDRSVVANTVLLFYWLFETFGNFAKLINILIRHTYEGIWYSGQTGFILTLFQVITC 180 ASILLLEALPKKPLMPHQHIHQTLTRRKPNPYDSANIFSRITFSWMSGLMKTGYEKYLVE 240 ADLYKLPRNFSSEELSQKLEKNWENELKQKSNPSLSWAICRTFGSKMLLAAFFKAIHDVL 300 AFTQPQLLRILIKFVTDYNSERQDDHSSLQGFENNHPQKLPIVRGFLIAFAMFLVGFTQT 360 SVLHQYFLNVFNTGMYIKSALTALIYQKSLVLSNEASGLSSTGDIVNLMSVDVQKLQDLT 420 QWLNLIWSGPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFLMRIQKKLQKSQMKYK 480 DERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCYMAVTSFQFNIVP 540 FLVSCCTFAVFVYTEDRALTTDLVFPALTLFNLLSFPLMIIPMVLNSFIEASVSIGRLFT 600 FFTNEELQPDSVQRLPKVKNIGDVAINIGDDATFLWQRKPEYKVALKNINFQAKKGNLTC 660 IVGKVGSGKTALLSCMLGDLFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAE 720 FYEKTIKACALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDDPL 780 AAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALLDNGEITQQGTYDEI 840 TKDADSPLWKLLNNYGKKNNGKSNEFGDSSESSVRESSIPVEGELEQLQKLNDLDFGNSD 900 AISLRRASDATLGSIDFGDDENIAKREHREQGKVKWNIYLEYAKACNPKSVCVFILFIVI 960 SMFLSVMGNVWLKHWSEVNSRYGSNPNAARYLAIYFALGIGSALATLIQTIVLWVFCTIH 1020 ASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFSNDIYKVDALLGRTFSQFFVNAVKVTF 1080 TITVICATTWQFIFIIIPLSVFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLA 1140 TVRGYSQQKRFSHINQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLK 1200 QGTLTAGMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAPLIVEGH 1260 RPPKEWPSQGDIKFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALF 1320 RMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWR 1380 ALELSHLKEHVLSMSNDGLDAQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAV 1440 DVETDKVVQETIRTAFKDRTILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKS 1500 LFYSLCMEAGLVNEN 1515 SEQIDNO:93 atgacgcttggtaatagacgccatgggcggaataatgagggaagctctaatatgaatatg 60 aatcgtaacgaccttgacgatgtttcccattacgagatgaaggaaatacaaccaaaggaa 120 aaacaaattggctctatagaaccggaaaatgaagtagaatattttgaaaaaacagtggaa 180 aaaaccattgaaaatatggaatatgaaggtgaacatcatgcatcttacttacggaggttc 240 attgactcgtttagaagagcggaaggctcgcatgcaaattccccagactcgagcaactct 300 aatgggactactcctatatccacaaaagattccagctctcaattggacaatgagttgaat 360 cggaagagctcatacatcactgttgatggtattaaacagtcaccacaagaacaagaacag 420 aaacaagaaaatttgaaaaagagtataaagccccgtcatacggtgatgatgtccctaggg 480 actggtattggtactggtttgctggtcggtaactccaaagttttgaacaatgcaggtccg 540 ggtggtttgatcattggttatgctattatgggtagttgtgtttactgtattattcaagct 600 tgtggtgaattagcggttatatacagtgatttgattggtggatttaatacatatcctttg 660 tttttggtcgaccctgcacttggcttttctgttgcttggcttttttgcttacaatggcta 720 tgtgtttgtcctctagaattggtcactgcatccatgactatcaaatattggacgacatct 780 gtgaacccggatgttttcgttgttatcttctacgtactaatcgttgttatcaacgttttt 840 ggagctaagggttatgcagaggcagatttcttcttcaattgttgtaaaattctgatgata 900 gttggatttttcattctcgccattattattgattgtggtggtgcaggtaccgatggttac 960 ataggtagcaaatattggcgtgatcccggagccttccgtggtgatacacccatccagagg 1020 ttcaaaggtgtcgttgccacatttgtcacagcagcgttcgcctttggtatgagtgaacag 1080 ctggctatgactgccagtgaacaatccaatccaagaaaggctattccatcggcggcaaag 1140 aaaatgatttatagaattctgtttgtgttcttggcgtctttaacgttagttggtttcctt 1200 gtaccttacacctcagatcaattgctaggggccgcaggttcagccactaaagcgtcgccc 1260 tacgtcatcgctgtctcctctcatggtgttcgtgtggttcctcatttcataaacgctgtc 1320 atcctgttgtctgttctttccgttgctaacggtgccttctataccagttctcgtattttg 1380 atgtcgttggccaaacaaggtaatgcacccaaatgtttcgattacatcgatagggaaggt 1440 agacctgctgctgctatgcttgtcagtgcattatttggtgtcattgcattctgtgcctca 1500 tctaaaaaggaagaggacgttttcacctggttgttagcaatctccggtttgtctcaatta 1560 ttcacgtggattaccatttgtttgtctcacattaggtttagaagagctatgaaagtgcaa 1620 ggaaggtccttaggagaggttggttataaatctcaagtcggtgtctgggggtcggcttac 1680 gctgtccttatgatggtgttagctttaatcgcccaattttgggttgccattgccccaatt 1740 ggtggaggaggtaagttaagtgcccaatcattttttgagaattatttggctatgccaatc 1800 tggattgctttatacatcttttacaaagtttggaaaaaagattggagtttattcattccc 1860 gctgataaagtagacttagtttctcatagaaacatctttgatgaagaattattaaaacaa 1920 gaagatgaagaatataaagagagattaagaaacggaccatactggaaaagagttcttgat 1980 ttctggtgttaa 1992 SEQIDNO:94 MTLGNRRHGRNNEGSSNMNMNRNDLDDVSHYEMKEIQPKEKQIGSIEPENEVEYFEKTVE 60 KTIENMEYEGEHHASYLRRFIDSFRRAEGSHANSPDSSNSNGTTPISTKDSSSQLDNELN 120 RKSSYITVDGIKQSPQEQEQKQENLKKSIKPRHTVMMSLGTGIGTGLLVGNSKVLNNAGP 180 GGLIIGYAIMGSCVYCIIQACGELAVIYSDLIGGFNTYPLFLVDPALGFSVAWLFCLQWL 240 CVCPLELVTASMTIKYWTTSVNPDVFVVIFYVLIVVINVFGAKGYAEADFFFNCCKILMI 300 VGFFILAIIIDCGGAGTDGYIGSKYWRDPGAFRGDTPIQRFKGVVATFVTAAFAFGMSEQ 360 LAMTASEQSNPRKAIPSAAKKMIYRILFVFLASLTLVGFLVPYTSDQLLGAAGSATKASP 420 YVIAVSSHGVRVVPHFINAVILLSVLSVANGAFYTSSRILMSLAKQGNAPKCFDYIDREG 480 RPAAAMLVSALFGVIAFCASSKKEEDVFTWLLAISGLSQLFTWITICLSHIRFRRAMKVQ 540 GRSLGEVGYKSQVGVWGSAYAVLMMVLALIAQFWVAIAPIGGGGKLSAQSFFENYLAMPI 600 WIALYIFYKVWKKDWSLFIPADKVDLVSHRNIFDEELLKQEDEEYKERLRNGPYWKRVLD 660 FWC 663 SEQIDNO:95 atgaataatggagacaataaaacgacattagaaaactcaaaaaatgcgtcactagctaat 60 ggaaattatgcgattcccacaaaactaaataggctgaaaaagaatgctgaccctagagtt 120 gctgcaatttcaggtgctttatctggtgcactatccgcaatgctggtctgtccttttgac 180 gttgcgaaaacaagattacaagcacaaggtctccaaaacatgacacaccaaagtcaacat 240 tataaggggttttttggtacatttgctactattttcaaggatgaaggtgctgctgggctt 300 tataaaggtctacagccgacggttttaggttatattcctactttgatgatttacttttcc 360 gtctatgatttctgtagaaaatattcggtcgatattttcccacatagtccgtttctctca 420 aacgcttcttctgcaattactgcaggtgccatctctacagttgcgacaaatccgatttgg 480 gtagtaaaaacaagacttatgctgcaaacaggtatcggtaaatattccacccattataag 540 ggtaccatagacacatttagaaagatcattcaacaagagggtgctaaggctctttatgcc 600 ggcttagtaccagccctgctggggatgctgaacgttgctatacagtttcctttatatgaa 660 aatttaaaaataaggttcggatattcagaatcgactgacgtatcgacagatgtgacgagc 720 tcaaactttcaaaaattaatattggcctctatgctatctaaaatggtagcatctaccgtg 780 acttatcctcacgaaatacttcgaactcgaatgcaactgaaatccgatcttccaaatact 840 gttcaacgccatctccttccattgattaaaattacgtataggcaagagggcttcgccggc 900 ttttactctgggtttgcaactaatttggtaaggacagtacctgctgctgtggtaacacta 960 gtatcgtttgaatattctaaaaagtatttaactactttttttcaataa 1008 SEQIDNO:96 MNNGDNKTTLENSKNASLANGNYAIPTKLNRLKKNADPRVAAISGALSGALSAMLVCPFD 60 VAKTRLQAQGLQNMTHQSQHYKGFFGTFATIFKDEGAAGLYKGLQPTVLGYIPTLMIYFS 120 VYDFCRKYSVDIFPHSPFLSNASSAITAGAISTVATNPIWVVKTRLMLQTGIGKYSTHYK 180 GTIDTFRKIIQQEGAKALYAGLVPALLGMLNVAIQFPLYENLKIRFGYSESTDVSTDVTS 240 SNFQKLILASMLSKMVASTVTYPHEILRTRMQLKSDLPNTVQRHLLPLIKITYRQEGFAG 300 FYSGFATNLVRTVPAAVVTLVSFEYSKKYLTTFFQ 335 SEQIDNO:97 atggtttcccaatttgctattgaggtgcgtaacctaacgtacaaattcaaagaaagctcc 60 gatccgtcagttgttgatatcaatcttcaaatcccatggaatacaagatctttagttgtg 120 ggtgccaatggtgctggtaaatccacccttttgaaattactaagcggtaagcatctttgc 180 cttgatggaaaaatcctggtcaatggtcttgatccattcagtccattatctatgaatcaa 240 gtggacgatgatgaaagtgttgaagattcgacgaactaccaaacgaccacttatctaggt 300 acggaatggtgccatatgagtatcattaatagggatatcggcgtcttggaactattaaaa 360 agtattggattcgatcattttagggaaagaggtgaaagattggttagaatcctggacatc 420 gatgtacgttggagaatgcacaggttaagtgatggacaaaagagaagagttcagttagcc 480 atggggctcttgaaaccttggagagttttactacttgatgaggtcactgtggatctcgat 540 gttattgccagagcaagacttctggagtttttaaagtgggagaccgaaaccagaagatgc 600 tcagtggtctacgctacacatatttttgacggcttggccaaatggcctaaccaagtatac 660 catatgaaatcaggtaagattgtggataatttagattatcagaaagacgtagagttctct 720 gaagtggtcaatgctaaagttaatggacaagtggcctttgaaaatgacaacaataaggtt 780 gttattagtaaagtgaatagtttgcatccattagcactagaatggttgaaacgtgataat 840 caaattcctgacaaagagattggtatataa 870 SEQIDNO:98 MVSQFAIEVRNLTYKFKESSDPSVVDINLQIPWNTRSLVVGANGAGKSTLLKLLSGKHLC 60 LDGKILVNGLDPFSPLSMNQVDDDESVEDSTNYQTTTYLGTEWCHMSIINRDIGVLELLK 120 SIGFDHFRERGERLVRILDIDVRWRMHRLSDGQKRRVQLAMGLLKPWRVLLLDEVTVDLD 180 VIARARLLEFLKWETETRRCSVVYATHIFDGLAKWPNQVYHMKSGKIVDNLDYQKDVEFS 240 EVVNAKVNGQVAFENDNNKVVISKVNSLHPLALEWLKRDNQIPDKEIGI 289 SEQIDNO:99 atgtctagacaagacgaaaattctgctttactagcgaataatgaaaataacaaaccatcg 60 tatacgggaaatgagaacggagtctacgataatttcaaattatcaaaaagtcaactttcg 120 gatcttcataaccctaaatcaataagatcatttgtcagattatttggatatgagtctaac 180 agcctcttcaaatacttgaaaacagataaaaatgcaggcatttctcttccagaaatatca 240 aattatcgaaagacaaaccggtataaaaattatggcgataattcacttcctgaaagaata 300 ccaaagtcttttttacaattagtatgggctgcttttaatgacaaaacaatgcaattactg 360 acagtcgccgctgttgtttcctttgttttaggtctatacgaactatggatgcaacctcca 420 cagtatgatcctgaaggaaataaaattaagcaagttgactggattgaaggggttgctatc 480 atgattgcggtctttgtggtagttctagtgagtgccgctaacgattaccagaaggagttg 540 caatttgcaaagctaaataaaaagaaggaaaaccgtaaaattatagtcataagaaatgat 600 caggaaatattaatttccattcaccacgttttagtcggtgatgtcatttcattacaaacc 660 ggtgatgttgtccccgctgattgtgttatgatatcagggaagtgtgaggcagatgaatca 720 tccatcactggtgaatctaacacaatacagaaatttccggtggataactcattaagagat 780 ttcaaaaaatttaattctatcgatagtcataaccatagcaaaccattagatataggtgac 840 gttaacgaagacggtaacaagattgctgattgtatgttgatttcaggttccagaattctc 900 tctggcttgggcaggggtgtcatcacgtccgtgggtataaactcagtttacggtcaaacc 960 atgacttcattaaatgccgaacctgaaagtactccattacagttacatttgagccaattg 1020 gctgataatatatccgtttacggttgcgtgtctgctataattcttttcttggtccttttc 1080 actaggtacttattttacataatacctgaggatggcaggttccatgatctagatcccgct 1140 caaaagggttctaaatttatgaacatttttatcacatctatcacggttattgtggtggct 1200 gttccggaaggtttaccattagctgtaactttggccttagcgtttgcaacaacaagaatg 1260 acaaaagacggtaatttagtacgggttttaagaagctgtgaaacgatgggatctgctact 1320 gcagtgtgctctgataagactggcactttgacagaaaatgtcatgactgtcgttcgtggc 1380 ttcccgggcaattctaaatttgatgatagtaaatcgttgcccgttagcgaacaaaggaag 1440 ctgaattctaagaaagtttttgaagaaaattgttcgtcatccttgagaaatgatttatta 1500 gccaatattgtcctgaattctaccgccttcgaaaacagagattataagaaaaacgataaa 1560 aatacaaatggtagtaaaaatatgtcaaaaaatttgagttttttagataagtgtaaatct 1620 agattatcgttttttaaaaaaggcaacagggaagatgacgaggatcaattattcaaaaat 1680 gtcaacaagggtaggcaagaaccctttattggctctaaaacggaaacagccttactcagt 1740 ttggcaagattatcattaggattacaaccgggagaattgcaatatttgagagatcaaccg 1800 atggaaaagtttaatatcgaaaaagttgttcaaacaattccgtttgaaagttctcgtaaa 1860 tgggccggcttagtggtaaagtacaaagaaggcaaaaataaaaaaccattttacaggttt 1920 ttcattaaaggtgcagcagaaattgtttccaagaattgttcgtacaagaggaattcagat 1980 gatactttggaagaaatcaatgaggacaataaaaaagaaactgatgatgaaatcaaaaat 2040 cttgcgtccgatgctctcagagccataagtgttgcccacaaagatttctgcgaatgtgat 2100 agctggccccctgaacagctgcgtgataaagactcaccaaatatagctgctcttgacttg 2160 ctatttaacagtcaaaagggcttaattctagatggtttacttgggattcaagacccttta 2220 cgtgcaggcgttagggagtcagtacaacagtgccaacgtgctggtgtaactgtgcgtatg 2280 gttactggtgacaatatattaacagcaaaagcaatcgcgaggaattgtgcgattctttct 2340 actgatattagttcagaggcttattctgcaatggaaggcactgaattcagaaagttaacg 2400 aaaaacgaacgtataagaatcctgccaaatttaagggtcttagcaaggtcttcgcctgag 2460 gataaaaggttattagtagaaacattgaaggggatgggagatgttgttgcggtcactggc 2520 gatggtacgaacgatgctccagctttaaagctagctgatgttggtttctcaatgggtatt 2580 tccggtacggaggttgccagagaggcttctgacattattttgatgactgatgatttctca 2640 gctattgtcaacgctattaagtggggaagatgtgtttcagtctccataaaaaagttcata 2700 cagtttcaattaattgttaatatcaccgcagtgattttaacgttcgtttcatccgttgca 2760 tctagtgatgaaacatcagtactgacggcggtccaactgttatggatcaatctaatcatg 2820 gatactctagcagctttagctttagccactgataaacccgatccaaatatcatggacaga 2880 aaacctaggggccgctcaacttctttgatttctgtgtcaacttggaaaatgattctatca 2940 caagctacattgcagttgatagttactttcattttgcatttttacgggccagagttattc 3000 ttcaagaaacatgaagatgaaataacaagtcaccaacagcagcaactgaatgccatgaca 3060 ttcaacacttttgtttggttgcaattttttaccatgttagtatcgagaaaattagatgaa 3120 ggtgatggtatatcaaactggagaggcaggatttctgccgccaatttgaatttcttccaa 3180 gacttgggtagaaactattattttctcacgatcatggcgatcattggcagctgtcaagtt 3240 ttaatcatgttttttggtggcgcaccattttctattgccagacaaaccaaatcaatgtgg 3300 ataaccgcggtactgtgtggtatgttgtctctaatcatgggggtgctagtgagaatctgc 3360 cccgatgaagtagcagtgaaggtatttccggctgctttcgttcaaagattcaagtacgta 3420 tttggactcgagttcctcagaaaaaaccatactggaaaacacgacgatgaagaagcgctg 3480 ttggaggaatctgatagtccagagtccaccgccttttattaa 3522 SEQIDNO:100 MSRQDENSALLANNENNKPSYTGNENGVYDNFKLSKSQLSDLHNPKSIRSFVRLFGYESN 60 SLFKYLKTDKNAGISLPEISNYRKTNRYKNYGDNSLPERIPKSFLQLVWAAFNDKTMQLL 120 TVAAVVSFVLGLYELWMQPPQYDPEGNKIKQVDWIEGVAIMIAVFVVVLVSAANDYQKEL 180 QFAKLNKKKENRKIIVIRNDQEILISIHHVLVGDVISLQTGDVVPADCVMISGKCEADES 240 SITGESNTIQKFPVDNSLRDFKKFNSIDSHNHSKPLDIGDVNEDGNKIADCMLISGSRIL 300 SGLGRGVITSVGINSVYGQTMTSLNAEPESTPLQLHLSQLADNISVYGCVSAIILFLVLF 360 TRYLFYIIPEDGRFHDLDPAQKGSKFMNIFITSITVIVVAVPEGLPLAVTLALAFATTRM 420 TKDGNLVRVLRSCETMGSATAVCSDKTGTLTENVMTVVRGFPGNSKFDDSKSLPVSEQRK 480 LNSKKVFEENCSSSLRNDLLANIVLNSTAFENRDYKKNDKNTNGSKNMSKNLSFLDKCKS 540 RLSFFKKGNREDDEDQLFKNVNKGRQEPFIGSKTETALLSLARLSLGLQPGELQYLRDQP 600 MEKFNIEKVVQTIPFESSRKWAGLVVKYKEGKNKKPFYRFFIKGAAEIVSKNCSYKRNSD 660 DTLEEINEDNKKETDDEIKNLASDALRAISVAHKDFCECDSWPPEQLRDKDSPNIAALDL 720 LFNSQKGLILDGLLGIQDPLRAGVRESVQQCQRAGVTVRMVTGDNILTAKAIARNCAILS 780 TDISSEAYSAMEGTEFRKLTKNERIRILPNLRVLARSSPEDKRLLVETLKGMGDVVAVTG 840 DGTNDAPALKLADVGFSMGISGTEVAREASDIILMTDDFSAIVNAIKWGRCVSVSIKKFI 900 QFQLIVNITAVILTFVSSVASSDETSVLTAVQLLWINLIMDTLAALALATDKPDPNIMDR 960 KPRGRSTSLISVSTWKMILSQATLQLIVTFILHFYGPELFFKKHEDEITSHQQQQLNAMT 1020 FNTFVWLQFFTMLVSRKLDEGDGISNWRGRISAANLNFFQDLGRNYYFLTIMAIIGSCQV 1080 LIMFFGGAPFSIARQTKSMWITAVLCGMLSLIMGVLVRICPDEVAVKVFPAAFVQRFKYV 1140 FGLEFLRKNHTGKHDDEEALLEESDSPESTAFY 1173 SEQIDNO:101 atgcctcaatctactccaagtcaagaagtacagcgtgtaccatgggataataaacctgct 60 ttgaagcagataacactccgagcaaccatagcaggtatcgctatagggtctctggtgcta 120 acatcaaattttcaatttggcctgcaaaccggttgggtttccatgatgtccctgccatcg 180 gcattgttagcttgtgctttctttaaaaatatctggccattaatatttccgaacgacagg 240 cctttcagtgacgttgaaaatgtatacgtacaaagtatggcagtagctgtcggaacaggc 300 ccattagcctttgggtttgtcggcgtcatacctgccatcgagaagttccttactaacgac 360 gaaagtggtggattaagggaacaaggacagtccttcacttttagagaattgttaatatgg 420 tccacagccctagcattcttcggtattttttttgcagttcctctaagaaagcaagtaatt 480 gttagagagaaacttcccttccccagtggtagcgccacggccactttaatttcagtgcta 540 aatggaactgagattttacaagaggtttctaagtcagagttattggaaatgaggcagagg 600 agattgaatgaatgccctgaagtgctacaacccaacagagatccagaggaggcggattat 660 ttaatgaactcttctcatagcgaacttggtgattatacggcaactagccaagatggaagt 720 tctatcctttctactggctctgagaactacagagcgaatattattattttattgaaaact 780 tttgttgtttcttcgctttacaccatggtgtcatattttgtaccggtaatacggtctatt 840 ccagtcttcggaaaatacctctcgaacaattatctctggaattttcagccgtcgcctgcg 900 tatataggccaagggataataatgggtcttccaacagtatcgtatatgcttatcgggtgc 960 ttcttaggctggggtgtgttagcaccattggcgagatacaaaagatgggtaccaccagat 1020 gctgatgtccacgactgggaggagggagtgcaaggatggattctttggtcgtcgctttca 1080 ataatggttgctgacagtgtagtcgcttttattgttgtgacagtgaagtccattgtgaaa 1140 tttattcttatagatgacaaagctgctttactgaacaacataatcgatgatacatttcaa 1200 tctatgttactggaggaggaacgcgccattaatagcagcagaagaaatacatatgttgat 1260 ggaaggcaggacaccgtaagattagtgagtagagataacgaaatagaagtagattcgaag 1320 catttggttcgctataccaccgttatcagtggatgtctagtctcctcgataatatgcatt 1380 gtttccataatatatttgtttgggatacaagtaattcccctatatgctattatcactgct 1440 ttgatacttgcgttgtttctatctattctcggtattcgagcacttggagagaccgatctg 1500 aatcctgtgagcggcattggtaagatctctcaattgatttttgcctttatcataccaagg 1560 gatagacctggatcagtgttaatgaacgtggtatcgggaggtattgcagaagcctctgcc 1620 caacaggcgggcgatttaatgcaggatttgaaaacggggcacctcctcggcgcctcccca 1680 agagctcagttctgtgcccaattgataggggcctgttggtcaattattttgtctagcttc 1740 atgtatttgtgctacaataaagtttattcaattccgagtgagcaattcaggataccgaca 1800 gcagtagtgtggatagattgtgcaagactagtaactggtaaagggctccctgataaggcc 1860 ttggagtgctccatgattctcggagtcatatttgccgttttatcattaatcagaaacact 1920 tatagagattacggatacgggtggatattatatattccgtctggtgtagcagtcggtgtt 1980 ggtatatttaattctcccagttttacaattgcaagattcatcggcgggtgggcttcgcat 2040 ttttggttgaagaatcataggggtgacttaaatgcgaaaacaaaaatgattgtattcagt 2100 tcggggttggtcttaggtgaaggtatctttagcgtaataaacatgctcttcatctgctta 2160 aatgtccctcactattag 2178 SEQIDNO:102 MPQSTPSQEVQRVPWDNKPALKQITLRATIAGIAIGSLVLTSNFQFGLQTGWVSMMSLPS 60 ALLACAFFKNIWPLIFPNDRPFSDVENVYVQSMAVAVGTGPLAFGFVGVIPAIEKFLTND 120 ESGGLREQGQSFTFRELLIWSTALAFFGIFFAVPLRKQVIVREKLPFPSGSATATLISVL 180 NGTEILQEVSKSELLEMRQRRLNECPEVLQPNRDPEEADYLMNSSHSELGDYTATSQDGS 240 SILSTGSENYRANIIILLKTFVVSSLYTMVSYFVPVIRSIPVFGKYLSNNYLWNFQPSPA 300 YIGQGIIMGLPTVSYMLIGCFLGWGVLAPLARYKRWVPPDADVHDWEEGVQGWILWSSLS 360 IMVADSVVAFIVVTVKSIVKFILIDDKAALLNNIIDDTFQSMLLEEERAINSSRRNTYVD 420 GRQDTVRLVSRDNEIEVDSKHLVRYTTVISGCLVSSIICIVSIIYLFGIQVIPLYAIITA 480 LILALFLSILGIRALGETDLNPVSGIGKISQLIFAFIIPRDRPGSVLMNVVSGGIAEASA 540 QQAGDLMQDLKTGHLLGASPRAQFCAQLIGACWSIILSSFMYLCYNKVYSIPSEQFRIPT 600 AVVWIDCARLVTGKGLPDKALECSMILGVIFAVLSLIRNTYRDYGYGWILYIPSGVAVGV 660 GIFNSPSFTIARFIGGWASHFWLKNHRGDLNAKTKMIVFSSGLVLGEGIFSVINMLFICL 720 NVPHY 725 SEQIDNO:103 atgggaaggactattaggagacgccggagtaattcgtcgctttcggaggccatatcagtt 60 tctttaggaataaatcaagactcatctgtgaacaagatgcatagagcgagtgttagcgca 120 atgtctcctccattatgccgttcatacatgagcggattttttactggtggaaactcacct 180 atgatcaataatttgtcggattcaaaacttcccatctcgaacaaacaacatcctaaagtg 240 atacatggatcagaaaatttgcataggcagacagctcaactatccaatgaattttgctcc 300 tcttctgtggaagaaaattctcccacaattaaggattacatggacattataggcaatggt 360 gatagaaaagatgatcaatctatgcgtactatagaagagaatattgatgaagaatattca 420 gatgagtactccagattgctacttagcccagcatcgtctaacgtggacgatgaccgaaat 480 cgaggactacagaatagttcactaccggaattagaagatggttacgcgggcggatatcag 540 tcacttcgtccctcccataatttaaggtttaggccaagaaacttgtggcatatgtgtacg 600 tcatttccttccaaatttgcacattatctgcccgcagcagtgttaggtttgcttttgaac 660 attttagatgccttatcttatggtatgatcatttttccaatcacagagccagttttttct 720 catttagggcccactggtatatccatgttttatatttccaccataatatcacaagccgtg 780 tactccggaggctggtcgagttttccttccgggattgggagtgaaatgattgaaattact 840 ccgttttatcatacaatggcattagctataaaagaggcattagcaggtaatgatgacgaa 900 atcataacgacaacgatattttgttatgtgataagttcgatgctcacaggtgtcgttttc 960 tatgcattgggtaaactacgactaggaaagatagtgggattttttccacgacacatattg 1020 attggctgtattggaggtgttggttatttcttgataattacaggaattgaagtcacaacg 1080 agggtggcgaaatttgaatattcatggccttttttttcagggctgtttacggattatgac 1140 acattagcgaaatggttattacctgtactattgactgtagttttaatcggcactcaacgc 1200 tactttaagaactcactcgttttgccaagtttttacatcttgacgttagttttgtttcat 1260 tttattgttgcgatcattccaacattatccttggatgctttgagacaagctggatggatt 1320 tttcctattgccaactcagatagtaaatggtatgaccattatagattatttaatgtccat 1380 aaagttcattggtcactagttttgcaacaaataccaacgatgatggcattgacatttttt 1440 ggtatcctacatgttcctataaatgttcctgcgttggctatgtcactacaaatggataag 1500 tatgatgttgacagagaattgattgcacatggttattccaacttttttagtggattatta 1560 ggttctgtccaaaattacttggtatataccaacagtgttctgtttattagggcgggcgct 1620 gattcgccattcgctgggttccttttaatagctttgactatctgtattatgatcattgga 1680 ccagtcataatatcattcattccaatctgtatagtgggctctctaattttcctactaggc 1740 tacgagttattagtggaagcgttggtcgatacatggaataaattgaatagattcgaatat 1800 ttgactgttgtcattattgttttcacgatgggtatctttgattttgtcctaggtatcatc 1860 gttggcattttaattgcatgtttttcgtttttggtggatagtacgaaattacaaaccatt 1920 aacggtgaatataatgggaacgtcgcaagaagtacagtatatcgtgattacgttcaaaca 1980 aaatttttggatggaattggtgaacaaatatatgttttaaagctccaaaaccttctgttt 2040 ttcggaacaatcatatctattgaagagaaaattgaaagattgctgcaaataagtaacaaa 2100 gatgcaacaaaacgcagaataaagtatttaatattggactttaaaaatattaatgccgac 2160 aatattgactattctgcggcagaaggtttcaatagaattaaaagattcacggaaaccaaa 2220 agaatcaaactaatcatatcttcaatcaaagaaagggaccgtatttacaacgccttcaat 2280 aatgtgggattactaaacgatgtggaattatttgctgatttaaacagtgcgttggaatgg 2340 tgtgaaaacgaattcctttttcaatataaacaattaagaaaaaaggcgaaagaaagattg 2400 gaagaaggaaagcaaaataatgtcgtatccgcagtaattgcagccactaaaaacaaaaaa 2460 attgatacaataggaaatggtttaaacaggggaagcaatggagacacagcgagaaactta 2520 atgtcactaccaaccaatactcctcgtaattaccaaatactttctgtagcacagaatgta 2580 tttgtaaacgacgaacaagcagtgaagaatttcaaaaaggagtacaaagatgatgaacct 2640 gtcctgcctatattgttatttgcattaaagcagtaccgacccgatataatatctgaagtt 2700 caaaaagtaagagaaaaggaaatcaagttttgggcacaactctgcccctacttcaccagg 2760 cgcagattagcaagtcaatcacatttactacatgcagacaacatttttttccttgtggaa 2820 acaggtatgttgaaggcaacatatgaactaccacaaggaaccttgtacgagattttttca 2880 aatggcacatgcttcggaaaaatcattgcgccagggaatgctatgcctagagaacaaaag 2940 ctcaccatcgaaactgaaactgattccgtattatgggttatagactctagctcgttgaac 3000 aaattgaaagaagacaatctagcattgtacgtggaggttgcattaatggtcatgtgtatc 3060 aaggacaccagattcaaagaattactaggttacacacttgttagcgcatga 3111 SEQIDNO:104 MGRTIRRRRSNSSLSEAISVSLGINQDSSVNKMHRASVSAMSPPLCRSYMSGFFTGGNSP 60 MINNLSDSKLPISNKQHPKVIHGSENLHRQTAQLSNEFCSSSVEENSPTIKDYMDIIGNG 120 DRKDDQSMRTIEENIDEEYSDEYSRLLLSPASSNVDDDRNRGLQNSSLPELEDGYAGGYQ 180 SLRPSHNLRFRPRNLWHMCTSFPSKFAHYLPAAVLGLLLNILDALSYGMIIFPITEPVFS 240 HLGPTGISMFYISTIISQAVYSGGWSSFPSGIGSEMIEITPFYHTMALAIKEALAGNDDE 300 IITTTIFCYVISSMLTGVVFYALGKLRLGKIVGFFPRHILIGCIGGVGYFLIITGIEVTT 360 RVAKFEYSWPFFSGLFTDYDTLAKWLLPVLLTVVLIGTQRYFKNSLVLPSFYILTLVLFH 420 FIVAIIPTLSLDALRQAGWIFPIANSDSKWYDHYRLFNVHKVHWSLVLQQIPTMMALTFF 480 GILHVPINVPALAMSLQMDKYDVDRELIAHGYSNFFSGLLGSVQNYLVYTNSVLFIRAGA 540 DSPFAGFLLIALTICIMIIGPVIISFIPICIVGSLIFLLGYELLVEALVDTWNKLNRFEY 600 LTVVIIVFTMGIFDFVLGIIVGILIACFSFLVDSTKLQTINGEYNGNVARSTVYRDYVQT 660 KFLDGIGEQIYVLKLQNLLFFGTIISIEEKIERLLQISNKDATKRRIKYLILDFKNINAD 720 NIDYSAAEGFNRIKRFTETKRIKLIISSIKERDRIYNAFNNVGLLNDVELFADLNSALEW 780 CENEFLFQYKQLRKKAKERLEEGKQNNVVSAVIAATKNKKIDTIGNGLNRGSNGDTARNL 840 MSLPTNTPRNYQILSVAQNVFVNDEQAVKNFKKEYKDDEPVLPILLFALKQYRPDIISEV 900 QKVREKEIKFWAQLCPYFTRRRLASQSHLLHADNIFFLVETGMLKATYELPQGTLYEIFS 960 NGTCFGKIIAPGNAMPREQKLTIETETDSVLWVIDSSSLNKLKEDNLALYVEVALMVMCI 1020 KDTRFKELLGYTLVSA 1036 SEQIDNO:105 atgggtctatcatctatctttggcggcggtgcaccatcacaacaaaaggaagcagccact 60 actgcaaagacaaccccaaaccctatagccaaggagctgaaaaaccaaattgctcaagaa 120 ctggctgtggctaatgcgactgaattagtgaacaaaatttctgagaactgctttgaaaaa 180 tgcttaacttcgccatacgctaccagaaacgatgcgtgcattgaccagtgtttggctaaa 240 tatatgagaagttggaatgtcatatcaaaggcttacatctccagaatccagaacgcctcc 300 gcttctggcgaaatctaa 318 SEQIDNO:106 MGLSSIFGGGAPSQQKEAATTAKTTPNPIAKELKNQIAQELAVANATELVNKISENCFEK 60 CLTSPYATRNDACIDQCLAKYMRSWNVISKAYISRIQNASASGEI 105 SEQIDNO:107 atggaggctacatcaagtgctctttcgtctacggcgaatctcgttaagacaatagttggc 60 gctggtacacttgccattccgtacagttttaaaagcgatggtgttctggtaggggttatt 120 cttacattattggcggcggtaacatccggtctgggtctctttgtgctatcgaaatgttcc 180 aagaccttaattaatccaagaaactcttctttcttcacattatgcatgctcacctatccc 240 actttggccccaatttttgatttggcaatgatagttcaatgctttggtgtgggcttaagt 300 tacttagttcttattggtgatctctttccaggactgtttggtggtgaaagaaattattgg 360 ataattgcatcagctgtaatcatcattcccctatgtttagtgaagaaactagatcaattg 420 aagtattctagtattctaggtcttttcgcgctagcatacatatcaattctggtgttcagt 480 cattttgtgtttgagctgggaaagggtgaattaacaaatatattaagaaatgacatatgc 540 tggtggaaaattcacgactttaaaggattattatcaacttttagcattataatttttgct 600 tttacgggatcaatgaacctattccccatgataaatgaattaaaagacaacagcatggaa 660 aatatcactttcgttatcaataattcgatatccttatcaacagcactatttttgatcgtt 720 ggtttatcaggatatttaaccttcggtaatgaaaccttgggtaatttaatgttgaactac 780 gatcctaactcaatttggatagtaattggcaaattctgtcttggctcaatgttaattctt 840 tccttcccgcttctctttcatccgctgcgcatagcagttaacaatgtcatcatctggatt 900 gagatcacttatggtggggcaaatcccgaagaggacccacaagtttcggaatacactcgt 960 gcttccaacctaagaccaattagcatgactgtggaagatccagcccagcccagtgatgca 1020 ctagacgcaacttcttataacgagcaagaatgtttactacctaacgggaactttgataat 1080 ggttcaattgaaagtcaagagaacaataatgatgaaagagggactatggcggtcgccggg 1140 gataacgagcatcatgcgccatttgttaagtctagattttactggattactgcattatta 1200 ctaataagcatgtataccttggcgttgtctgtccagtcatttgcactggttctttcattt 1260 gtaggggctacaggttcaacgtctatttcattcactttacctggattattaggttacaaa 1320 ttaataggcttggattctttggctattgggaagatgattccaccaaaagatagattttac 1380 aaaaggtgcagcttattgctagtcttctacggactatctgtgatgtttttgtcattgtat 1440 gtaactgtattcaaccgttcagatgaagcctaa 1473 SEQIDNO:108 MEATSSALSSTANLVKTIVGAGTLAIPYSFKSDGVLVGVILTLLAAVTSGLGLFVLSKCS 60 KTLINPRNSSFFTLCMLTYPTLAPIFDLAMIVQCFGVGLSYLVLIGDLFPGLFGGERNYW 120 IIASAVIIIPLCLVKKLDQLKYSSILGLFALAYISILVFSHFVFELGKGELTNILRNDIC 180 WWKIHDFKGLLSTFSIIIFAFTGSMNLFPMINELKDNSMENITFVINNSISLSTALFLIV 240 GLSGYLTFGNETLGNLMLNYDPNSIWIVIGKFCLGSMLILSFPLLFHPLRIAVNNVIIWI 300 EITYGGANPEEDPQVSEYTRASNLRPISMTVEDPAQPSDALDATSYNEQECLLPNGNFDN 360 GSIESQENNNDERGTMAVAGDNEHHAPFVKSRFYWITALLLISMYTLALSVQSFALVLSF 420 VGATGSTSISFTLPGLLGYKLIGLDSLAIGKMIPPKDRFYKRCSLLLVFYGLSVMFLSLY 480 VTVFNRSDEA 490 SEQIDNO:109 atggcaccggaaatttttgttaaattcaagtgtgcaagtagagacataaagctactatgg 60 gcgtccgtctttcttagacttctatcatatggtttaacaaatcaagttttgacgcttttt 120 ttaaatgccatcaatatgacagaggataaaattgggctgtttatgtcattaacactggca 180 ggggatgtaatttgctcttacattcttacttggtatgcggattcctggggccgaagaaga 240 gtcctagtttatggttgtgcaatgatgttgttaagtgggttggttttcagttttagcgaa 300 aatttcaccctcttgctagtatttgctatcttcggtgttatatcgccttcaagtgatgaa 360 gtcgggcctttcaaatctatagaagaggccatgattgcacatctgagtcctcataatgca 420 agaccagagatttatgctattcacgccttggttggaacaattggaagcgctctaggtgca 480 ataatttgtggtatatttgtagatcttttgaaaagaactggtttagctgctactgatttg 540 caatgttataaattagttttcttactgtatgccttcttcgccttttgcaaaatggtcatc 600 atgctcttattatcagatgctacagaattggacgggcattatgaacatacagattgcaat 660 gaagaaacagctgaaccattggacgttaacgatgaaactgcaccattaatgagacaagca 720 actcacccagaagaaagatccaacaaactatctaaggagaccgtttcggttttgatgaaa 780 ttgttagtaatcttcatggtcgactctctcgggtccgggtttatgacaagtggctggatg 840 gtttactactatagtaagcaatttttgatgggatctctggcgttgggtactttatttttc 900 atcacgcaactggttatggcatcttccaccatcccatcatcaataattgccagatgtttt 960 ggcccagtaagagccacactattggtccaaattccatcagggatattttctattctcatc 1020 cctatggccaagaattacttgcccttatctattttgtttttgaatctgcattttgcaaca 1080 actgccatggacgttacaccaaggcaaattctattaacaaatatcatcaaaccaagagat 1140 ttaaccaaagttatgggggtggtcaacattggaaagacatttgctcggtgtgttggtcca 1200 atattcacgggtatacttgctaacaataattatttatggctatgttacatcattagtggg 1260 tccttggtgataacggcggatctaatactggcatgcatgtttttaggagtggacgctaaa 1320 attaaaaagcaaatgaaccgccattaa 1347 SEQIDNO:110 MAPEIFVKFKCASRDIKLLWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLA 60 GDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSENFTLLLVFAIFGVISPSSDE 120 VGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKRTGLAATDL 180 QCYKLVFLLYAFFAFCKMVIMLLLSDATELDGHYEHTDCNEETAEPLDVNDETAPLMRQA 240 THPEERSNKLSKETVSVLMKLLVIFMVDSLGSGFMTSGWMVYYYSKQFLMGSLALGTLFF 300 ITQLVMASSTIPSSIIARCFGPVRATLLVQIPSGIFSILIPMAKNYLPLSILFLNLHFAT 360 TAMDVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILANNNYLWLCYIISG 420 SLVITADLILACMFLGVDAKIKKQMNRH 448 SEQIDNO:111 atgacatctatagataatagacctttgccgttcatataccagttcacagccggtgccatt 60 gccggcgtctcggagctattggtgatgtatccattggacgtggtgaagacaagaatgcaa 120 ttacaagtgacaaccaaaggtcatcccgctgttgttgcagcgaaagcagcagtagatcac 180 tacacgggcgtgatggattgtcttacaaaaattgtgaagaaggaaggattttcgcatctt 240 tacaagggtatcacatcgcctatattaatggaggctccgaaaagagcaattaagttctcc 300 ggaaacgatacattccaaacgttttataaaaagattttccccacgcccaatggggagatg 360 actcaaaaaatcgccatatacagtggtgcgtccgctggcgccgtggaagcctttgtcgtc 420 gcgccttttgaactagtgaagattagattacaggatgtgaattcacagttcaagacaccc 480 attgaagttgtaaagaatagtgttgtgaaaggtggtgttttgtcacttttcaatgggttg 540 gaagccactatctggagacacgttctttggaatgccggttatttcggtataatattccaa 600 attcggaagcttttgccggcggctaaaacaagcacggaaaagaccagaaatgatttgatc 660 gcaggtgctattggtggcactgtcgggtgcttgttgaatacaccatttgacgtggtaaaa 720 tctaggatccaaagaagttccgggccgctgaggaagtacaactggtccctgccttcagtg 780 ctgttagtttaccgtgaggaagggtttaaagcattgtataagggatttgcgccaaaggtc 840 atgagacttgcccccggtggtgggttattgttggtagttttcacgaacgtcatggatttt 900 ttcagagaagtcaagtatggtaaaaaacaatga 933 SEQIDNO:112 MTSIDNRPLPFIYQFTAGAIAGVSELLVMYPLDVVKTRMQLQVTTKGHPAVVAAKAAVDH 60 YTGVMDCLTKIVKKEGFSHLYKGITSPILMEAPKRAIKFSGNDTFQTFYKKIFPTPNGEM 120 TQKIAIYSGASAGAVEAFVVAPFELVKIRLQDVNSQFKTPIEVVKNSVVKGGVLSLFNGL 180 EATIWRHVLWNAGYFGIIFQIRKLLPAAKTSTEKTRNDLIAGAIGGTVGCLLNTPFDVVK 240 SRIQRSSGPLRKYNWSLPSVLLVYREEGFKALYKGFAPKVMRLAPGGGLLLVVFTNVMDF 300 FREVKYGKKQ 310 SEQIDNO:113 atgtcttcgaacgattcgaacgataccgacaagcaacatacacgtctggatcctaccggt 60 gtggacgacgcctacatccctccggagcagccggaaacaaagcaccatcgctttaaaatc 120 tctagggacaccctgagagaccactttatcgctgcggtcggtgagttctgcggcacattc 180 atgtttttatggtgcgcttacgttatctgcaatgtcgctaaccatgatgtcgcactcgtt 240 gcagcgcctgacggttcccatccgggtcaattgattatgattgccatcggtttcggattt 300 tccgtcatgttttctatctggtgttttgccggtgtctctggtggggctttgaatcctgct 360 atgtcgctttcgctgtgcttggcgagagccgtctctcctacaagatgtgtcgttatgtgg 420 gtttcgcagattgttgctggaatggccgctggaggcgctgcaagcgccatgacacctggt 480 gaagtcctctttgccaattctttgggcctgggctgctctaggacgaggggtctgttcctg 540 gagatgttcggcaccgctatcctatgtttaacagtcttaatgacggctgtggagaagcgt 600 gaaaccaactttatggctgcgctgcccatcggcatctccctgtttatcgcacacgtcgct 660 ttgactgcatacacaggcacaggtgtcaaccctgcgaggtccttgggtgctgctgtcgca 720 gccagatacttccctcattaccactggatttattggattggcacgctgttaggatccatt 780 ttagcatggtctgtatggcaattattgcaaatcttagactacacaacctacgttaccgct 840 gaaaaggctgccagcaccaaggaaaaagctcaaaaaaaaggtgaaaccagcagttcctct 900 gctgtggctgaagtctaa 918 SEQIDNO:114 MSSNDSNDTDKQHTRLDPTGVDDAYIPPEQPETKHHRFKISRDTLRDHFIAAVGEFCGTF 60 MFLWCAYVICNVANHDVALVAAPDGSHPGQLIMIAIGFGFSVMFSIWCFAGVSGGALNPA 120 MSLSLCLARAVSPTRCVVMWVSQIVAGMAAGGAASAMTPGEVLFANSLGLGCSRTRGLFL 180 EMFGTAILCLTVLMTAVEKRETNFMAALPIGISLFIAHVALTAYTGTGVNPARSLGAAVA 240 ARYFPHYHWIYWIGTLLGSILAWSVWQLLQILDYTTYVTAEKAASTKEKAQKKGETSSSS 300 AVAEV 305 SEQIDNO:115 atgagtgaaacagtcaaagataaagttataattgatgagaaggtatccacaaaaggtact 60 gttgattacgccgagggtgctgagtattctgagaggctttcaaatcattcatcagacttt 120 tctcagtggtatacggatgaacagatactgcactttatgaagaagctgggttatgaaaat 180 cgcactctttatgatattccggaagacgttgcgtatatcctcaaaaaaatgcctgaattg 240 acacttgaggattccttcaaaatactaaaagactctatcatctatttcaaggatgatgag 300 aacattccacacgatcaatatgaggagtggaagagattggttgacttggaggacttggat 360 tcaaaagaggggatagatgaatatgatagctttgacattagagcatttgcttctgctatt 420 aaatttcattcgccttaccaagaggttagagctgttgttgatccagaagatgatcccacc 480 attccagtggagacattccgagcatattttctggcaataatttggtctgtcatcggttca 540 ggatttaatgagtttttttcacacagggtggtttcaatttcactgaatactccaattatc 600 caaatgtttttatatatctgtggtaaggcttgggctaaaactatcccctgttggactata 660 accatcaggggcagaaagtatggtatcaatatcgataaaccatggacccaaaaagagcaa 720 atgttttcaaccttgttatatgcaatttgtcaaggcgcgttctatactcattacaatatt 780 ctaacgcaaaaactcttttaccattctgctttctcgtttggctaccaatttttactttcg 840 ttatccgtacaatttattggatttggatttgctggcatccttagaaaattcgttgtttat 900 ccagcccgtgcactatggccaacagtcatgccaactattgctatcaacaaggcactattg 960 ggtaaagaaaagcatgaatctggaatgagcaggtataaattctttttcttgacttttttt 1020 atcatgttcatctataactggtttcccacttacattattaatattctaaacactttcaat 1080 tggatgacctggatcaagccaagtaacattaatctcgcaaacatcacgggaggagtcact 1140 ggtcttgggattaatcctatctcatcttttgactggaatgttatttcgtttaattctcct 1200 ttagtttacccattttggtcatacttaacacaatatcttggttgcatattagcagcttta 1260 attgttattgcagtatactatagtaattatatgagttgccaatacctgccaatattcaca 1320 aattctttgtatactaatactggccattcctttaaagttactgaggtattagacagtgac 1380 aataagctagatgtgaaaaaatatcaaagctactcgccaccatactatagtgctggaaat 1440 ttggtatcatatggtgctttcatttgcgcatatcctctgatgattacatggtcgtttatt 1500 gtacactcaaagttattgttcaatgctttcaaagattgggctttgaatttgtgggccatg 1560 agaaaacttaaatcttgggtcacaatgttcaaaagcgattacagggcgctcgacgattat 1620 gatgacccacattctaatgccatgaaaaactataaagaagttccagattggtggtatttt 1680 gccatattgataggttcacttgttgttggaatagctgttgtagagcactacccaacaaat 1740 acaccagtttggggtctttttgtttgtttaggatttaattttgttttcttgattccaact 1800 actatccttcaagcaaccactggttattcgtttggtttgaatctactaattgaaatggtg 1860 atggggtacgctttaccaggtaatccaatcgccataatgattttgaaggcttttggttat 1920 aacatcgacggccaagcagataattacgtttctaacttaaaaatagcgcattattgtaag 1980 attccgccaatggcgctattcaggggacaatgtgttatagttttcattcagatatttgtc 2040 aatctaggtgttctgaattggcaaatctccaatatcaaagacttttgcacacctcatcaa 2100 aacgcaaaattcacctgtcctgatgctgtgacctactataatgcttccgttgtctggggt 2160 gcaattgggccaaaaagaattttcaattacatttatccaatatttaaatggtgttggttg 2220 ataggcgcatgcattggcatattttttggtgtttggaagcgctggggtaagttttatccc 2280 agatattttgacccaatgttatttgtaggtggaatgcttaatatgagccctccatataac 2340 ctgatgtattacacttctggtatgattgttagttacatttcccagtactacatgaaaaga 2400 caccatttaaatctgtgggagaaatataattatgttttatcggcaggcttttcaacgggc 2460 ttggttttatcagctattatcattttctttgctgtccaatataaagacacagcttttaat 2520 tggtggggcaatacagttccgtatgctggtgccgatggcgttggctatcctctaaagaac 2580 ataactgatacagcaaatggctatttcggctatgctccaggacactatccatga 2634 SEQIDNO:116 MSETVKDKVIIDEKVSTKGTVDYAEGAEYSERLSNHSSDFSQWYTDEQILHFMKKLGYEN 60 RTLYDIPEDVAYILKKMPELTLEDSFKILKDSIIYFKDDENIPHDQYEEWKRLVDLEDLD 120 SKEGIDEYDSFDIRAFASAIKFHSPYQEVRAVVDPEDDPTIPVETFRAYFLAIIWSVIGS 180 GFNEFFSHRVVSISLNTPIIQMFLYICGKAWAKTIPCWTITIRGRKYGINIDKPWTQKEQ 240 MFSTLLYAICQGAFYTHYNILTQKLFYHSAFSFGYQFLLSLSVQFIGFGFAGILRKFVVY 300 PARALWPTVMPTIAINKALLGKEKHESGMSRYKFFFLTFFIMFIYNWFPTYIINILNTFN 360 WMTWIKPSNINLANITGGVTGLGINPISSFDWNVISFNSPLVYPFWSYLTQYLGCILAAL 420 IVIAVYYSNYMSCQYLPIFTNSLYTNTGHSFKVTEVLDSDNKLDVKKYQSYSPPYYSAGN 480 LVSYGAFICAYPLMITWSFIVHSKLLFNAFKDWALNLWAMRKLKSWVTMFKSDYRALDDY 540 DDPHSNAMKNYKEVPDWWYFAILIGSLVVGIAVVEHYPTNTPVWGLFVCLGFNFVFLIPT 600 TILQATTGYSFGLNLLIEMVMGYALPGNPIAIMILKAFGYNIDGQADNYVSNLKIAHYCK 660 IPPMALFRGQCVIVFIQIFVNLGVLNWQISNIKDFCTPHQNAKFTCPDAVTYYNASVVWG 720 AIGPKRIFNYIYPIFKWCWLIGACIGIFFGVWKRWGKFYPRYFDPMLFVGGMLNMSPPYN 780 LMYYTSGMIVSYISQYYMKRHHLNLWEKYNYVLSAGFSTGLVLSAIIIFFAVQYKDTAFN 840 WWGNTVPYAGADGVGYPLKNITDTANGYFGYAPGHYP 877 SEQIDNO:117 atgaagagtactttgagtttaactttatgtgttatatcgcttctattaaccctttttctg 60 gcggccttggatattgttatagtggttactttatatgatacaattggcattaagttccat 120 gacttcggcaatattggttggttagttactggatatgctctttctaatgctgttttcatg 180 ttattatggggtcgcttggccgaaatacttggtacaaaggagtgcttaatgatttctgtt 240 attgtatttgaaatagggtctttgatttctgctctttcgaattcaatggcgactctgatt 300 agcggaagagtcgttgctgggtttggaggaagtggaattgaatcacttgcttttgtagtt 360 ggaacatccattgtccgagaaaaccatagaggaattatgataacggcactcgctatatcg 420 tatgtcattgcagagggagtcgggccttttattggtggtgcatttaatgaacatttgtct 480 tggagatggtgcttttatataaatcttccaatcggtgcgtttgcgttcataatattggca 540 ttttgtaacacatctggagaaccacatcaaaaaatgtggctaccatcaaaaatcaaaaaa 600 attatgaactatgactatggcgaattattgaaagcaagtttttggaagaatacatttgaa 660 gtacttgtatttaaactagacatggttgggattattttatcttcagcaggctttacacta 720 ctgatgttaggtctttcatttggtggaaacaacttcccatggaattcgggtatcattatt 780 tgcttttttaccgtgggccctatcttattgttactattttgtgcttacgactttcatttt 840 ctgtcattatcggggcttcactatgacaacaagcggatcaaaccgttactgacatggaat 900 attgcctcaaattgtggcatatttacaagctccataacaggattcctttcttgctttgct 960 tatgaattacagtctgcttatttagtccagctttatcaactagtatttaaaaaaaagcct 1020 acattagcgagtatacatctttgggaactatcaattccagctatgattgcaactatggcc 1080 atagcatatctaaattcaaaatatggcatcatcaaaccggcaattgtttttggtgtgctt 1140 tgtgggattgttggatctggtttatttacgctaatcaatggcgaactctctcagtcaata 1200 ggttattcaattctcccaggaatagcttttggtagtattttccaagcaacgttattaagc 1260 tcccaggtgcagataacatcagacgatccagactttcaaaacaagtttattgaagtcaca 1320 gctttcaactcgttcgccaaatccttgggctttgcgtttggagggaatatgggggcaatg 1380 atattcactgcatcactcaaaaaccagatgcgctcttcccaattaaacataccacaattt 1440 acgtctgtagaaacacttttagcgtatagcacagaacattatgatggcccccaatcttca 1500 ctatcaaagttcataaacacagctatccatgacgttttttactgcgccttaggatgctat 1560 gctctttcattcttctttggaatattcacttcgagtaagaaaacaacaatatcagccaaa 1620 aagcaacaatga 1632 SEQIDNO:118 MKSTLSLTLCVISLLLTLFLAALDIVIVVTLYDTIGIKFHDFGNIGWLVTGYALSNAVFM 60 LLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVV 120 GTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILA 180 FCNTSGEPHQKMWLPSKIKKIMNYDYGELLKASFWKNTFEVLVFKLDMVGIILSSAGFTL 240 LMLGLSFGGNNFPWNSGIIICFFTVGPILLLLFCAYDFHFLSLSGLHYDNKRIKPLLTWN 300 IASNCGIFTSSITGFLSCFAYELQSAYLVQLYQLVFKKKPTLASIHLWELSIPAMIATMA 360 IAYLNSKYGIIKPAIVFGVLCGIVGSGLFTLINGELSQSIGYSILPGIAFGSIFQATLLS 420 SQVQITSDDPDFQNKFIEVTAFNSFAKSLGFAFGGNMGAMIFTASLKNQMRSSQLNIPQF 480 TSVETLLAYSTEHYDGPQSSLSKFINTAIHDVFYCALGCYALSFFFGIFTSSKKTTISAK 540 KQQ 543 SEQIDNO:119 atgtcagaagatcaaaaaagtgaaaattcggtaccttctaaggttaatatggtgaatcgc 60 accgatatactgactacgatcaagtcattgtcatggcttgacttgatgttgccatttact 120 ataattctctccataatcattgcagtaataatttctgtctatgtgccttcttcccgtcac 180 acttttgacgctgaaggtcatcccaatctaatgggagtgtccattcctttgactgttggt 240 atgattgtaatgatgattcccccgatctgcaaagtttcctgggagtctattcacaagtac 300 ttctacaggagctatataaggaagcaactagccctctcgttatttttgaattgggtcatc 360 ggtcctttgttgatgacagcattggcgtggatggcgctattcgattataaggaataccgt 420 caaggcattattatgatcggagtagctagatgcattgccatggtgctaatttggaatcag 480 attgctggaggagacaatgatctctgcgtcgtgcttgttattacaaactcgcttttacag 540 atggtattatatgcaccattgcagatattttactgttatgttatttctcatgaccacctg 600 aatacttcaaatagggtattattcgaagaggttgcaaagtctgtcggagtttttctcggc 660 ataccactgggaattggcattatcatacgtttgggaagtcttaccatagctggtaaaagt 720 aattatgaaaaatacattttgagatttatttctccatgggcaatgatcggatttcattac 780 actttatttgttatttttattagtagaggttatcaatttatccacgaaattggttctgca 840 atattgtgctttgtcccattggtgctttacttctttattgcatggtttttgaccttcgca 900 ttaatgaggtacttatcaatatctaggagtgatacacaaagagaatgtagctgtgaccaa 960 gaactacttttaaagagggtctggggaagaaagtcttgtgaagctagcttttctattacg 1020 atgacgcaatgtttcactatggcttcaaataattttgaactatccctggcaattgctatt 1080 tccttatatggtaacaatagcaagcaagcaatagctgcaacatttgggccgttgctagaa 1140 gttccaattttattgattttggcaatagtcgcgaggatccttaaaccatattatatatgg 1200 aacaatagaaattaa 1215 SEQIDNO:120 MSEDQKSENSVPSKVNMVNRTDILTTIKSLSWLDLMLPFTIILSIIIAVIISVYVPSSRH 60 TFDAEGHPNLMGVSIPLTVGMIVMMIPPICKVSWESIHKYFYRSYIRKQLALSLFLNWVI 120 GPLLMTALAWMALFDYKEYRQGIIMIGVARCIAMVLIWNQIAGGDNDLCVVLVITNSLLQ 180 MVLYAPLQIFYCYVISHDHLNTSNRVLFEEVAKSVGVFLGIPLGIGIIIRLGSLTIAGKS 240 NYEKYILRFISPWAMIGFHYTLFVIFISRGYQFIHEIGSAILCFVPLVLYFFIAWFLTFA 300 LMRYLSISRSDTQRECSCDQELLLKRVWGRKSCEASFSITMTQCFTMASNNFELSLAIAI 360 SLYGNNSKQAIAATFGPLLEVPILLILAIVARILKPYYIWNNRN 404 SEQIDNO:121 atgtattcaattgttaaagagattattgtagatccttacaaaagactaaaatggggtttt 60 attccagtaaagcggcaggtggaagacctgccagatgacttaaattcaacagaaattgtc 120 actatctccaacagtatccagagtcatgaaacagctgaaaatttcatcacgactacaagt 180 gaaaaagatcaactacattttgagactagtagctatagtgaacataaagacaatgtgaac 240 gttactagaagttatgaatatagagatgaagccgataggccatggtggagatttttcgat 300 gaacaagagtatcggatcaatgaaaaggaaagatctcacaataaatggtatagttggttc 360 aaacagggtacctctttcaaagaaaaaaaattattaattaaattggatgtccttttagcc 420 ttttattcttgtattgcttattgggtgaaatatctggatacggttaatataaacaacgct 480 tacgtttcgggaatgaaggaagatttaggctttcaaggtaatgatttggtgcatactcaa 540 gtaatgtacacagttggtaatattatatttcaattgccatttttgatttacctgaacaag 600 ctcccattaaactatgttttaccaagcctcgacttatgttggtcgcttttaaccgttggt 660 gctgcatatgtcaattctgtaccacacttgaaagcaattaggtttttcattggggctttt 720 gaagcgccaagttatttggcataccaatatttgtttggttccttttacaaacatgatgaa 780 atggtgcgtcgttctgctttttactatttgggccagtatatcggtattctatccgctggt 840 gggatccagtcagccgtatattcatcgttaaatggtgtaaatggtttagagggatggaga 900 tggaactttattattgacgctattgtgtctgtcgtagtgggccttattggattttactcc 960 ctgccaggtgacccatacaactgttattctattttcttaactgatgatgaaattaggttg 1020 gcgaggaaaagattaaaagaaaaccaaacaggtaaaagtgattttgaaacaaaagtattc 1080 gatattaaactgtggaaaacaattttcagtgattggaaaatatacattttaactttatgg 1140 aatattttctgttggaatgacagtaatgtttcatctggggcatacctactatggttgaaa 1200 tctttgaaaagatactctattcctaagctcaatcagttatccatgattactccgggttta 1260 ggtatggtttatttgatgcttactggtattattgcagataaattacactctcgttggttt 1320 gcgattatttttactcaggttttcaatatcattggtaactccatattagccgcttgggac 1380 gtcgcagaaggagccaaatggtttgcatttatgctgcaatgttttggttgggctatggct 1440 cctgttttatactcttggcaaaacgatatttgtcgccgagatgctcaaactagagctatt 1500 actttagttacaatgaatattatggctcaatcatctaccgcatggataagtgttttggtt 1560 tggaaaacagaagaagctcccaggtatttaaaggggtttactttcactgcatgttctgct 1620 ttttgtctctccatttggacttttgttgtactctacttctataaacgtgatgaaaggaac 1680 aatgccaagaagaacggtattgtgctttataactctaaacatggtgtggaaaagccaacg 1740 tcaaaagacgttgaaaccttatcagtatctgatgaaaaataa 1782 SEQIDNO:122 MYSIVKEIIVDPYKRLKWGFIPVKRQVEDLPDDLNSTEIVTISNSIQSHETAENFITTTS 60 EKDQLHFETSSYSEHKDNVNVTRSYEYRDEADRPWWRFFDEQEYRINEKERSHNKWYSWF 120 KQGTSFKEKKLLIKLDVLLAFYSCIAYWVKYLDTVNINNAYVSGMKEDLGFQGNDLVHTQ 180 VMYTVGNIIFQLPFLIYLNKLPLNYVLPSLDLCWSLLTVGAAYVNSVPHLKAIRFFIGAF 240 EAPSYLAYQYLFGSFYKHDEMVRRSAFYYLGQYIGILSAGGIQSAVYSSLNGVNGLEGWR 300 WNFIIDAIVSVVVGLIGFYSLPGDPYNCYSIFLTDDEIRLARKRLKENQTGKSDFETKVF 360 DIKLWKTIFSDWKIYILTLWNIFCWNDSNVSSGAYLLWLKSLKRYSIPKLNQLSMITPGL 420 GMVYLMLTGIIADKLHSRWFAIIFTQVFNIIGNSILAAWDVAEGAKWFAFMLQCFGWAMA 480 PVLYSWQNDICRRDAQTRAITLVTMNIMAQSSTAWISVLVWKTEEAPRYLKGFTFTACSA 540 FCLSIWTFVVLYFYKRDERNNAKKNGIVLYNSKHGVEKPTSKDVETLSVSDEK 593 SEQIDNO:123 atgccgtcaaacgtacgttcgggagtcttaactttgctccatacagcatgtggagcaggc 60 gtacttgcaatgccgtttgcattcaagccatttgggttaatgcctggtctgataacgcta 120 acattttgcggaatatgttccttatgtgggctgctattacagactcgaatagcgaagtac 180 gtacctaaatctgagaacgcctcgtttgctaaactcacccaactaatcaatccgtcaata 240 agtgtagtgttcgattttgccattgctgttaaatgttttggcgttggtgtatcttactta 300 attattgttggtgacttagtgccacagatagtgcagtcaattttttatcgtaacgatgat 360 aacatgagtggttcgcaagagcatcacatgttcttagacaggcgtttgtatataactctg 420 atcatagtgtttgttatctcccctttatgctttaaaagaagtttgaattctctacgatat 480 gcttctatgattgccattgttagtgtcgcatatttatctggtttgattatttaccatttt 540 gtaaatcggcatcagctagagagagggcaagtatattttatggtacctcacggagattct 600 cagtctcattctcccctgactacattgccaatttttgtgtttgcttacacttgtcaccac 660 aatatgttcagtgtaattaatgagcaagtggataagagcttcaaggtaatcaggaggatt 720 ccgatttttgccatcgtgttggcctattttttatacatcataattggtggtacaggttat 780 atgacatttggtgagaatattgtaggaaatatcctcactttatacccgaattccatctcc 840 accaccatcgggaggttagcaatgctgctattagttatgttagcatttccattgcaatgc 900 catccttgcagatcatcggtaaaaaacataattatattcattgaaaatttcagaaaaggt 960 aagttatacgataacagagctagctttattccattagacaactttaatagtgaagatccg 1020 caggaggcgccaacccaacaaaacaacgaagagccaaatctgcgtagtgagtctttacgg 1080 catatcaatattatcaccctttgtatcttactgttctcatatctactggctatttcaatt 1140 acgtctctagcaaaagtcctagcaatagttggtgccacgggatctacgtcgatttctttc 1200 attttgccaggcctttttggttataaattaattggctcagaatttacgggcacgaatgaa 1260 agagtaccgacaagcataaaaatattcaaatacttaagtttatctctattcatctggggg 1320 atagcagtaatggtagcttcactatcagcgattgtatttttgggcacatcatcacattga 1380 SEQIDNO:124 MPSNVRSGVLTLLHTACGAGVLAMPFAFKPFGLMPGLITLTFCGICSLCGLLLQTRIAKY 60 VPKSENASFAKLTQLINPSISVVFDFAIAVKCFGVGVSYLIIVGDLVPQIVQSIFYRNDD 120 NMSGSQEHHMFLDRRLYITLIIVFVISPLCFKRSLNSLRYASMIAIVSVAYLSGLIIYHF 180 VNRHQLERGQVYFMVPHGDSQSHSPLTTLPIFVFAYTCHHNMFSVINEQVDKSFKVIRRI 240 PIFAIVLAYFLYIIIGGTGYMTFGENIVGNILTLYPNSISTTIGRLAMLLLVMLAFPLQC 300 HPCRSSVKNIIIFIENFRKGKLYDNRASFIPLDNFNSEDPQEAPTQQNNEEPNLRSESLR 360 HINIITLCILLFSYLLAISITSLAKVLAIVGATGSTSISFILPGLFGYKLIGSEFTGTNE 420 RVPTSIKIFKYLSLSLFIWGIAVMVASLSAIVFLGTSSH 459 SEQIDNO:125 atgatgaaggaatcgaaatctatcactcaacatgaggttgagagagaatctgtttcttcc 60 aagcgtgccattaaaaagagattacttctgtttaaaatagacttgtttgtgctatcattt 120 gtttgcttgcaatactggattaattatgtcgaccgtgtcggtttcaccaatgcatatata 180 tccggtatgaaggaagatcttaagatggtcggaaacgatttgaccgtgtctaacacagtt 240 ttcatgattggttacattgtaggtatggtccccaataatttaatgttattgtgtgttccg 300 cccaggatatggctaagtttttgtacgtttgcttggggtttattgaccttgggaatgtac 360 aaagttacatcgttcaaacatatttgcgcaattagattctttcaagccttatttgagagt 420 tgcacattttcaggaacacattttgttttgggttcgtggtataaagaagacgaattgccc 480 attagaagtgctatttttacaggtagcggtttggtgggatctatgttcagtggatttatg 540 caaacaagtatctttactcatttgaatgggcggaatggcttggcgggttggagatggtta 600 ttcattattgatttttgtatcacattacccattgcaatttatgggtttattttcttcccc 660 ggccttcctgatcaaacaagtgctgttagcaaattttctatgacgagatacatttttaat 720 gaacaagagctacattatgctaggagaaggctccccgctagggacgaaagcacccggtta 780 gactggtcgactattcctagagtcttaaaaaggtggcactggtggatgttctctcttgtt 840 tgggttctgggaggtgagaacttgggtttcgcatctaattctacatttgcattatggtta 900 caaaaccaaaaatatacgttggcgcaaagaaataattatccttcggggatatttgccgta 960 ggtatagtttctacgctttgttctgctgtatatatgagtaagatcccaagagctaggcat 1020 tggcatgtttctgttttcatatcattggtaatggttattgttgcggtactaatacgtgca 1080 gacccactaaatccaaaagtcgtcttttctgcacagtatcttggaggcgtagcatacgct 1140 ggacaagcggtttttttttcgtgggcaaacattatttgtcatgcagatcttcaagaacgt 1200 gctatcgttcttgcttccatgaatatgttttcaggggccgttaacgcatggtggtctata 1260 ttattctttgcttcagatatggtgcccaagtttgagagaggttgctacgccctcttggct 1320 acggcaatatcaagcggaattgtctcggtcgtcatacgctcactacagataaaagagaat 1380 ttgtctaagaaacaggttccttatatagatgctaatgacatgcccggagaagatgacgat 1440 gacgacaaccaggataatgaaaatgatggcgacgacgagagtatggaagttgaacttcat 1500 aatgaggaaatggccgaaatttcaaatcctttccgatag 1539 SEQIDNO:126 MMKESKSITQHEVERESVSSKRAIKKRLLLFKIDLFVLSFVCLQYWINYVDRVGFTNAYI 60 SGMKEDLKMVGNDLTVSNTVFMIGYIVGMVPNNLMLLCVPPRIWLSFCTFAWGLLTLGMY 120 KVTSFKHICAIRFFQALFESCTFSGTHFVLGSWYKEDELPIRSAIFTGSGLVGSMFSGFM 180 QTSIFTHLNGRNGLAGWRWLFIIDFCITLPIAIYGFIFFPGLPDQTSAVSKFSMTRYIFN 240 EQELHYARRRLPARDESTRLDWSTIPRVLKRWHWWMFSLVWVLGGENLGFASNSTFALWL 300 QNQKYTLAQRNNYPSGIFAVGIVSTLCSAVYMSKIPRARHWHVSVFISLVMVIVAVLIRA 360 DPLNPKVVFSAQYLGGVAYAGQAVFFSWANIICHADLQERAIVLASMNMFSGAVNAWWSI 420 LFFASDMVPKFERGCYALLATAISSGIVSVVIRSLQIKENLSKKQVPYIDANDMPGEDDD 480 DDNQDNENDGDDESMEVELHNEEMAEISNPFR 512 SEQIDNO:127 atgaatcgtgttggtatagacgtagatcatatgataggggtcctgcttctggccgtagtg 60 gtggtgttttgggttggcgcttcgtgtttgactaatgaattgctcgagacaaacgcgtac 120 aataaacctttcttccttacttatctaaacatatcatcgtttgctctttatttgacgcca 180 gatctatggaggataatccaatcaagaaggaagagcttgcaggaacggacagaacgaaca 240 ttacctattcacacacaagaatctttttcagagttcctacctttactatcttcaactcct 300 tctacttcttcaaatttgtcttcgatagcggacacgaaagtgaaggatacaatgaggttg 360 agtctgctattttgcgtcttgtggttcgtggcaaatttggcggctaacgctgctttgtcg 420 tataccacagtggcttcgtcaacaattctttcatcgacatcctcattttttaccttattt 480 cttgccactagtctaggaatagaaactttttcgacaaaaaaactgctggggttatttgtg 540 tctttgtttggaattatcttaattgtgatgcaatcctcgaagcaacaggattctgtgagt 600 gcttcctcctttttggtaggtaacactttagcactgctggggtcattgggttacagtgtc 660 tatacaacccttttgaaatacgaaatatcatccaaaggtctcagactagacattcagatg 720 tttcttggttatgttggtatcttcacgtttctgttgttttggccaattttaataatcctg 780 gatataacacatatggaaacttttgaactaccaagtaacttccacatttcttttcttgtc 840 atgttaaattgtatcattatctttgttagtgactatttttggtgtaaagccctcattttg 900 acatcacccttggtggttaccgttgccttaacttttactatcccgttagccatgttcgct 960 gattttgtatggcgagaggcattttttacgccttggtatatcattggtgttattttcatt 1020 tttgtttcattctttctagttaaccatcggggagaatctgctgttgaaaaggactgtgct 1080 gcggttgaaaaaggacctatcttggatgcctaa 1113 SEQIDNO:128 MNRVGIDVDHMIGVLLLAVVVVFWVGASCLTNELLETNAYNKPFFLTYLNISSFALYLTP 60 DLWRIIQSRRKSLQERTERTLPIHTQESFSEFLPLLSSTPSTSSNLSSIADTKVKDTMRL 120 SLLFCVLWFVANLAANAALSYTTVASSTILSSTSSFFTLFLATSLGIETFSTKKLLGLFV 180 SLFGIILIVMQSSKQQDSVSASSFLVGNTLALLGSLGYSVYTTLLKYEISSKGLRLDIQM 240 FLGYVGIFTFLLFWPILIILDITHMETFELPSNFHISFLVMLNCIIIFVSDYFWCKALIL 300 TSPLVVTVALTFTIPLAMFADFVWREAFFTPWYIIGVIFIFVSFFLVNHRGESAVEKDCA 360 AVEKGPILDA 370 SEQIDNO:129 atggttagttcaagtgtttccattttggggactagcgccaaggcatccacttctctaagt 60 agaaaggatgaaattaaactaacccctgaaacaagggaagctagcttggacattccatac 120 aaacccattattgcatactggacggtgatgggtctctgtctgatgattgcctttggtgga 180 ttcatttttggttgggatacaggaaccatttcagggtttattaaccaaacagatttcaag 240 agaaggtttggtgagttacaaagggacggcagttttcaactatcagatgtcaggacaggg 300 ctaattgtcggtatcttcaacataggttgtgctttaggtggcctaacgctgggacgcctg 360 ggcgatatttatgggcgtaaaatcggcttaatgtgtgttatactggtgtatgttgttggt 420 atcgtgatccagattgcttcctctgacaaatggtatcaatattttattggtagaattgtt 480 tctggaatgggtgttggaggtgttgctgtgctgtcgccaactttgatctcagaaatttcc 540 ccaaagcacctaagaggcacttgtgtctctttttaccagctaatgattacccttggaatt 600 ttcttgggctactgtaccaattatggtacaaagaaatattcaaattcaatacagtggcgg 660 gttcccttgggtttgtgttttgcgtgggcaatctttatggtgattggaatggttatggtt 720 ccggaatcgcccagatatttagtagaaaaaggtaagtatgaagaagctagaaggtctttg 780 gccaaatcaaacaaggtcacagttactgatccaggcgttgtttttgagtttgatactata 840 gttgcaaatatggaattagaaagggctgttggaaatgccagttggcacgaactcttctca 900 aataaaggagcaattctaccaagggtaataatgggaatcgttatccagtcactgcaacag 960 cttactggctgtaattattttttctactacggcacgaccattttcaatgctgttggaatg 1020 caagactctttcgagacttccattgtccttggggctgttaattttgcttctacatttgtt 1080 gcactatacattgtggataaatttgggcgtcgaaaatgtttattgtgggggtctgcctcg 1140 atggcaatttgtttcgtcatattcgccaccgttggcgtcactagattatggccacaaggg 1200 aaagaccaaccttcttcgcaaagtgctggtaatgttatgatcgtttttacttgtttcttc 1260 attttctcttttgccattacttgggctcctatcgcctatgtcattgtggcagaaacttat 1320 ccattaagagttaaaaatcgtgccatggccattgcggttggtgcgaactggatgtggggt 1380 ttcttgattggatttttcacaccctttatcactagatccataggattttcttatggctat 1440 gttttcatgggttgcttaatcttttcgtacttctacgttttcttctttgtttgcgaaaca 1500 aagggattaactctggaggaagttaatgaaatgtacgaagaaagaataaagccatggaag 1560 tccggaggttggattcccagttctagaagaacaccacaaccaacaagcagtacaccatta 1620 gttattgttgatagtaaataa 1641 SEQIDNO:130 MVSSSVSILGTSAKASTSLSRKDEIKLTPETREASLDIPYKPIIAYWTVMGLCLMIAFGG 60 FIFGWDTGTISGFINQTDFKRRFGELQRDGSFQLSDVRTGLIVGIFNIGCALGGLTLGRL 120 GDIYGRKIGLMCVILVYVVGIVIQIASSDKWYQYFIGRIVSGMGVGGVAVLSPTLISEIS 180 PKHLRGTCVSFYQLMITLGIFLGYCTNYGTKKYSNSIQWRVPLGLCFAWAIFMVIGMVMV 240 PESPRYLVEKGKYEEARRSLAKSNKVTVTDPGVVFEFDTIVANMELERAVGNASWHELFS 300 NKGAILPRVIMGIVIQSLQQLTGCNYFFYYGTTIFNAVGMQDSFETSIVLGAVNFASTFV 360 ALYIVDKFGRRKCLLWGSASMAICFVIFATVGVTRLWPQGKDQPSSQSAGNVMIVFTCFF 420 IFSFAITWAPIAYVIVAETYPLRVKNRAMAIAVGANWMWGFLIGFFTPFITRSIGFSYGY 480 VFMGCLIFSYFYVFFFVCETKGLTLEEVNEMYEERIKPWKSGGWIPSSRRTPQPTSSTPL 540 VIVDSK 546 SEQIDNO:131 atgtcgctgatcagcatcctgtctcccctaattacttccgagggcttagattcaagaatc 60 aaaccttcaccaaaaaaggatgcctctactaccactaagccatcactatggaaaactact 120 gagttcaaattctactacattgcatttctggtcgtggttcccttgatgttctatgctggg 180 ttacaagctagttcgcccgaaaatccaaactatgcaagatacgaacgtctcctatctcaa 240 ggttggttatttggcagaaaagtagacaatagtgattctcaatataggtttttcagggac 300 aattttgcgctattgtcagttttaatgctagtccacacttctataaaacgcattgtactt 360 tattcaacaaatatcactaaattgaggtttgatctgatatttggtttgatctttttagtg 420 gccgctcatggtgtcaattcgataagaattttagcccatatgctaattttatatgccatc 480 gcccatgtactaaagaactttagaagaatagccaccatcagcatttggatttatggtatt 540 tctacgctttttattaacgacaacttcagagcatatccatttggtaatatttgctctttt 600 ttaagcccattggaccattggtatagaggtatcattccaagatgggatgtctttttcaat 660 tttactcttttgagagtcttaagttacaacttggacttcttagagaggtgggagaattta 720 caaaagaagaaaagtccatcctatgaatcaaaagaagctaaatcagccattttgctcaat 780 gaacgtgctagattaactgctgcacaccccatacaggactacagcttaatgaattatatt 840 gcatatgttacttacacgccacttttcattgccggccccattataacattcaatgattat 900 gtttaccaatcgaaacataccttgccatcaataaatttcaaattcattttttactatgcg 960 gtgagattcgttattgctctcttatctatggagttcattttacactttctccacgttgtg 1020 gcaatctcaaaaaccaaagcgtgggaaaatgacacacctttccagatttccatgattggc 1080 ttatttaatttgaatattatttggctaaaactactgattccgtggaggctgtttaggctg 1140 tgggctttgctagacggaatcgatacacctgaaaatatgatcaggtgtgttgataacaat 1200 tacagttcactagcattctggagagcttggcatagaagctacaataagtgggttgtccgt 1260 tacatatatattcctctaggtggttcaaaaaatagagttttgacatcactagcagtcttt 1320 tccttcgtagctatatggcatgacatcgaactaaagttattattatggggttggctaata 1380 gttttgttcctcttaccagaaatttttgctacccaaattttctctcattataccgacgca 1440 gtctggtacagacacgtttgcgctgtcggtgctgttttcaacatatgggttatgatgatc 1500 gctaatctttttggattctgcttgggctctgacggtactaaaaaattactaagcgatatg 1560 ttctgtaccgtatctggtttcaaatttgtaattttggcaagcgttagtttattcatcgca 1620 gtacaaataatgtttgaaatcagagaagaagaaaagaggcacggaatttacctaaaatgc 1680 tga 1683 SEQIDNO:132 MSLISILSPLITSEGLDSRIKPSPKKDASTTTKPSLWKTTEFKFYYIAFLVVVPLMFYAG 60 LQASSPENPNYARYERLLSQGWLFGRKVDNSDSQYRFFRDNFALLSVLMLVHTSIKRIVL 120 YSTNITKLRFDLIFGLIFLVAAHGVNSIRILAHMLILYAIAHVLKNFRRIATISIWIYGI 180 STLFINDNFRAYPFGNICSFLSPLDHWYRGIIPRWDVFFNFTLLRVLSYNLDFLERWENL 240 QKKKSPSYESKEAKSAILLNERARLTAAHPIQDYSLMNYIAYVTYTPLFIAGPIITFNDY 300 VYQSKHTLPSINFKFIFYYAVRFVIALLSMEFILHFLHVVAISKTKAWENDTPFQISMIG 360 LFNLNIIWLKLLIPWRLFRLWALLDGIDTPENMIRCVDNNYSSLAFWRAWHRSYNKWVVR 420 YIYIPLGGSKNRVLTSLAVFSFVAIWHDIELKLLLWGWLIVLFLLPEIFATQIFSHYTDA 480 VWYRHVCAVGAVFNIWVMMIANLFGFCLGSDGTKKLLSDMFCTVSGFKFVILASVSLFIA 540 VQIMFEIREEEKRHGIYLKC 560 SEQIDNO:133 atgaataggattctatctagtgcatcgttgctatccaatgttagcatgccaaggcaaaac 60 aagcataaaattacaaaggcgttatgttatgcaattatagtagcctcaatcggttcaata 120 caatttggttaccacttgtcggaattaaatgcacctcagcaggtgctttcgtgctcagaa 180 tttgacattcccatggagggctatccctatgacagaacatggctgggaaaaagaggatat 240 aagcaatgtataccattgaatgatgaacagattggaatcgtgacctccgttttttgcatt 300 ggaggcattttgggctcttattttgccaccagtctggccaatatttatggaaggaagttc 360 tcaagtttaattaactgcacattgaatatcgtcggttcgctgataatcttcaattcgaat 420 agttataggggcttaatcattggtagaattctagtgggtatttcgtgtggctctttgatc 480 gtgattataccccttttcattaaggaagttgctccaagcggttgggaaggtttactgggt 540 tcgatgacacaaatctgtatcaggttaggggtcttgttgacacaaggaatagccctccca 600 ctgactgattcataccgttggaggtggattttgtttggtagcttccttatcgcggtattg 660 aattttttcatgtggtttatagtcgatgaatctccaaaatggttgttagcacatggaaga 720 gtcaccgatgctaagttatctctatgtaagctacgtggcgtgacttttgatgaagccgca 780 caagagatacaggattggcaactgcaaatagaatctggggatccgttgattgaaccaacc 840 accacgaactctattagcggttctaattcattatggaaatacttgagggacagaacaaat 900 gtcaagtctcgccatgttatcactgtattgttatttggccaacaattctgcggtataaac 960 tccattgtactatatggtaccaagataattagtcaactgtatcctcagcacgcaattagg 1020 ataaactttttcattagtatggtgaatgtattagtcaccatactagtttctctgctaatt 1080 catagtttgccacgtaaaccgcttctgatgacgtccaccgtcttagtttctgttaccgcc 1140 ttcattatgggaatagcaatgaaccataataaaatgaaccttttgattgtgttttcattt 1200 atatatatgggcgttttcacgatggggttaaatccgttgccatttataataatgagagaa 1260 gtatcaaaaccacaggatatggtccttgcgcaaagatatggtaccatttgcaattgggta 1320 ggaacttttatcattgcatatactttccctattattcatgatgttttgtcaggttatgtt 1380 ttcatcatttttgctatcatagcatgctcaataagcgcctttatctggaagaaggttccg 1440 gagaccaagaggagcggctaa 1461 SEQIDNO:134 MNRILSSASLLSNVSMPRQNKHKITKALCYAIIVASIGSIQFGYHLSELNAPQQVLSCSE 60 FDIPMEGYPYDRTWLGKRGYKQCIPLNDEQIGIVTSVFCIGGILGSYFATSLANIYGRKF 120 SSLINCTLNIVGSLIIFNSNSYRGLIIGRILVGISCGSLIVIIPLFIKEVAPSGWEGLLG 180 SMTQICIRLGVLLTQGIALPLTDSYRWRWILFGSFLIAVLNFFMWFIVDESPKWLLAHGR 240 VTDAKLSLCKLRGVTFDEAAQEIQDWQLQIESGDPLIEPTTTNSISGSNSLWKYLRDRTN 300 VKSRHVITVLLFGQQFCGINSIVLYGTKIISQLYPQHAIRINFFISMVNVLVTILVSLLI 360 HSLPRKPLLMTSTVLVSVTAFIMGIAMNHNKMNLLIVFSFIYMGVFTMGLNPLPFIIMRE 420 VSKPQDMVLAQRYGTICNWVGTFIIAYTFPIIHDVLSGYVFIIFAIIACSISAFIWKKVP 480 ETKRSG 486 SEQIDNO:135 atgaaaggcgaacctaagacttacagcatgagcgacctctcatactacggtgagaaagca 60 caacaacagaacgagaaacagcaaaaacaatatgttgtgagacgaaattctacgcagtca 120 acatcaaaacaaaacgtgagcgtggtgctcgaggacaacgccagcgaaagtaatgaacta 180 cctaaagggtttatcttgtacgcatctttgatagcattggctttgtcgctgtttctggca 240 gccttggatatcatgatagtttctacaatcattgaagaagtagctaaacagtttggatcg 300 tactctgagatcgggtggttatttaccgggtatagcttaccaaacgctctgttggcgttg 360 atatggggaagaattgccacacctatcggattcaaggagaccatgctatttgctattgtc 420 atttttgaaatcgggtcgctgatctctgctttagcaaattcaatgagtatgctcattggt 480 ggtagagttattgctggagtcggcggttgtggtattcaaagtttatcgttcgtcattggt 540 tcaaccctggtagaggagtcgcagagaggcatactaattgctgttttgagttgttcgttt 600 gctattgcatctgttgttgggcctttccttggaggagttttcacctccagcgtcacatgg 660 agatggtgcttctatgttaatttaccgatcggtggcctagcatttttcttattcctgttc 720 ttttataacccaggtttaagtacatttcaagagacaatggataacatccgcaaatttcca 780 tcacagtttatcgaaattgttcggaatgtagcatatcatttattgaaaatcaaagggttt 840 agcaaacttaatgggtggagaaagccgttcatggaattgattttcatgtatgatattatc 900 gagtttgtgttttgttcagctggattcacatgtattctattggctttcacatttggcggt 960 aaccggtatgcttggaactctgcatccatcattattcttttcatcatcggtatagtcctg 1020 gtagtgttagcaggtatctatgatttccttgtcttccccaaatttaatatagtgaaagca 1080 acaccacattaccaaccattaatgtcatggacaaatatcaagaaaccaggtattttcacg 1140 gttaatatagccttgtttctcacttgtgcaggatatatcagtcagtttacgtatattgtg 1200 caatacttccaattaatttacaatgattccgcctggagagccgctgtacacctggttgct 1260 tgcattatttctacagtcgttacagcaatactttgcggtgctatcaccgacaaaacccgc 1320 caaatcaaaccgattattgttatttcaagcatttttggtgttgttggtgcgggtatatta 1380 accctattgaacaataatgccaataactctgctcacatcggccttttgatattacctggc 1440 gttgctttcggtggtttggcacaaagttccatgctcgcttctcaaattcagttagacaag 1500 aagagcccaacttttcgatcagattttgtctctattaccacttttaacacattttgcaaa 1560 aatctaggtcaagcactgggaggtgtcatctctaacactgttttcagtgctgctgctatc 1620 aagaaattaaccaaggctaatattcagctcccagatggtaccacggtagacaatctggta 1680 atctataggcagaccaatttcgatggctctcattccaaattgggcaatataatttctgaa 1740 tctctcactgacgtcttttacatggcattaggattttatgcattatctctcatttttgct 1800 gtttttgcttcaaataagaaagtcacagcaagcctgagataa 1842 SEQIDNO:136 MKGEPKTYSMSDLSYYGEKAQQQNEKQQKQYVVRRNSTQSTSKQNVSVVLEDNASESNEL 60 PKGFILYASLIALALSLFLAALDIMIVSTIIEEVAKQFGSYSEIGWLFTGYSLPNALLAL 120 IWGRIATPIGFKETMLFAIVIFEIGSLISALANSMSMLIGGRVIAGVGGCGIQSLSFVIG 180 STLVEESQRGILIAVLSCSFAIASVVGPFLGGVFTSSVTWRWCFYVNLPIGGLAFFLFLF 240 FYNPGLSTFQETMDNIRKFPSQFIEIVRNVAYHLLKIKGFSKLNGWRKPFMELIFMYDII 300 EFVFCSAGFTCILLAFTFGGNRYAWNSASIIILFIIGIVLVVLAGIYDFLVFPKFNIVKA 360 TPHYQPLMSWTNIKKPGIFTVNIALFLTCAGYISQFTYIVQYFQLIYNDSAWRAAVHLVA 420 CIISTVVTAILCGAITDKTRQIKPIIVISSIFGVVGAGILTLLNNNANNSAHIGLLILPG 480 VAFGGLAQSSMLASQIQLDKKSPTFRSDFVSITTFNTFCKNLGQALGGVISNTVFSAAAI 540 KKLTKANIQLPDGTTVDNLVIYRQTNFDGSHSKLGNIISESLTDVFYMALGFYALSLIFA 600 VFASNKKVTASLR 613 SEQIDNO:137 atgtctaaacaatttagtcataccaccaacgacagaagatcatcgattatctactccacc 60 agtgtcgggaaggcagggcttttcacgcctgcagactacatcccacaggagtcagaagaa 120 aacttaattgagggcgaagagcaagagggtagtgaagaagaaccttcctataccggcaat 180 gacgatgagacggagagggaaggtgaataccattcgttgttagatgccaacaattcgcgg 240 acattgcaacaagaagcgtggcaacaaggttatgactctcacgaccgtaagcggttgctt 300 gacgaagaacgggacctgctaatagacaacaaactgctctctcaacacggcaacggtggg 360 ggagatatagaaagtcacggacatggccaagcaattggaccggacgaggaagaaagacca 420 gctgagattgcaaatacgtgggagagcgcgatcgagagtggtcagaaaatcagcacaact 480 tttaagagagaaacgcaagtgatcacgatgaatgcgttgccgctaatcttcacctttatc 540 ttgcaaaattcgttgtcactagcatctattttctccgtctcacatttagggacgaaagag 600 ctaggtggtgttacactcggttctatgactgctaacatcacgggtcttgctgctattcaa 660 ggtctgtgtacatgtctggacacactgtgtgcgcaggcatacggtgccaaaaactaccac 720 ttggtgggtgtgctagtgcagagatgtgctgtgatcaccatcttggcgttcttgccaatg 780 atgtatgtttggtttgtttggtcggaaaagatcctagcactaatgattccggagagagaa 840 ctatgcgcgctagcggctaactatctacgtgtaaccgcattcggtgtgccaggattcatc 900 ctttttgaatgtggtaagaggttcctacaatgtcaaggtatattccatgcatccacaatc 960 gtgctctttgtgtgcgcacccttgaacgcattgatgaactacttacttgtttggaatgac 1020 aagattgggattgggtaccttggtgcgccattatcggttgtgatcaactactggttgatg 1080 acgctcggattactaatatacgcaatgaccaccaagcacaaggagagaccactcaaatgc 1140 tggaatggtatcatccctaaggaacaagcatttaagaactggcgtaagatgattaaccta 1200 gctattcccggcgtggtgatggtggaggcagagttcctcggctttgaagtgttgacaatt 1260 ttcgcttcccatctgggcaccgatgccttgggcgctcagtcgattgtggctacgattgcg 1320 tctcttgcataccaagtgcctttctctatctccgtttctaccagtacacgtgtagccaat 1380 tttatcggcgcgtcgctatacgacagctgcatgatcacgtgccgcgtgtccttattgttg 1440 tcctttgtgtgctcctcaatgaacatgttcgttatctgccgttataaggaacaaatcgca 1500 agtctattttctactgagagcgctgtagtgaagatggtcgtggacacactacctcttctt 1560 gcgttcatgcaattattcgatgcctttaatgcgtccaccgccggatgcctacgtggtcaa 1620 gggagacaaaaaaataggtgggtacatcaacctagtcgcattctactgcctaggtgtgcc 1680 catggcatatgtgttagcattcctgtatcatctgggtgtaggcggcttatggttgggtat 1740 aactag 1746 SEQIDNO:138 MSKQFSHTTNDRRSSIIYSTSVGKAGLFTPADYIPQESEENLIEGEEQEGSEEEPSYTGN 60 DDETEREGEYHSLLDANNSRTLQQEAWQQGYDSHDRKRLLDEERDLLIDNKLLSQHGNGG 120 GDIESHGHGQAIGPDEEERPAEIANTWESAIESGQKISTTFKRETQVITMNALPLIFTFI 180 LQNSLSLASIFSVSHLGTKELGGVTLGSMTANITGLAAIQGLCTCLDTLCAQAYGAKNYH 240 LVGVLVQRCAVITILAFLPMMYVWFVWSEKILALMIPERELCALAANYLRVTAFGVPGFI 300 LFECGKRFLQCQGIFHASTIVLFVCAPLNALMNYLLVWNDKIGIGYLGAPLSVVINYWLM 360 TLGLLIYAMTTKHKERPLKCWNGIIPKEQAFKNWRKMINLAIPGVVMVEAEFLGFEVLTI 420 FASHLGTDALGAQSIVATIASLAYQVPFSISVSTSTRVANFIGASLYDSCMITCRVSLLL 480 SFVCSSMNMFVICRYKEQIASLFSTESAVVKMVVDTLPLLAFMQLFDAFNASTAGCLRGQ 540 GRQKNRWVHQPSRILLPRCAHGICVSIPVSSGCRRLMVGYN 581 SEQIDNO:139 atgaagactcagtactctctaatacgaaaaatttgggcacattcagtaacagaatttctg 60 aaatcccagtggtttttcatctgtttggctattttaatcgttattgcaagatttgctccg 120 aattttgcaagagacggagggttaattaaaggccaatatagtattgggtacggctgcgtc 180 gcctggatttttctccaaagtggcctgggaatgaaatcaaggtcactaatggcaaatatg 240 ttaaattggagagctcatgccactattctggttctgagtttccttattacctcgtccata 300 gtatatggattttgttgcgcggtaaaggctgctaatgatccgaaaatagatgactgggta 360 cttatcggtctaattttgactgccacttgtccaacaaccgtggcttcaaacgttatcatg 420 actacgaatgcaggtggaaatagccttttgtgcgtttgtgaagtattcattggaaatttg 480 ttgggtgcgtttattacacctgcattggttcaaatgtttactaaccgcgcaccatttgca 540 tacggcaaccctgccactggaaatggcattggtgcgctttatggccgtgttatgaaacag 600 gttggtctctctgtattcgtacccttgtttgtgggtcaggttattcaaaattgctttccg 660 aagggtactgcttattacctgggctttttgaaaaaataccatattaaaattggatcttac 720 atgcttttattgattatgtttagttcattctcaactgccttttatcaggatgcgtttact 780 agcgtttctcatgtttgcatcatatttctctgcttttttaatttgggaatttatatattc 840 ttcacgggtctgtcatacttatgtgcaaggccatggttcatcctcaagcttttccctcat 900 gaaccaatagagggcaaatctacaagattgtaccgctattcgtataatatctttaggcct 960 ttttattattcaaaggaagatgcgatttgcattatgttttgtggcccggctaaaactgca 1020 gcactgggtgtatcactaattacttcacaatacggcgataaaaaagaacacctgggtaag 1080 ttgttggttcccttggttttatatcaagttgagcaagtcatgacggcaaatttctttgta 1140 agcttgttcaaaagatggatacaaaaggacgctcaagcagacggaagcgagtcatcttgt 1200 gcaaatgagaatgaggaagttgatttggaaaagatcatatcaattggaactggtgaaaat 1260 caatccgttctgtcgaacaacgtcccatatacacaaccaaggtga 1305 SEQIDNO:140 MKTQYSLIRKIWAHSVTEFLKSQWFFICLAILIVIARFAPNFARDGGLIKGQYSIGYGCV 60 AWIFLQSGLGMKSRSLMANMLNWRAHATILVLSFLITSSIVYGFCCAVKAANDPKIDDWV 120 LIGLILTATCPTTVASNVIMTTNAGGNSLLCVCEVFIGNLLGAFITPALVQMFTNRAPFA 180 YGNPATGNGIGALYGRVMKQVGLSVFVPLFVGQVIQNCFPKGTAYYLGFLKKYHIKIGSY 240 MLLLIMFSSFSTAFYQDAFTSVSHVCIIFLCFFNLGIYIFFTGLSYLCARPWFILKLFPH 300 EPIEGKSTRLYRYSYNIFRPFYYSKEDAICIMFCGPAKTAALGVSLITSQYGDKKEHLGK 360 LLVPLVLYQVEQVMTANFFVSLFKRWIQKDAQADGSESSCANENEEVDLEKIISIGTGEN 420 QSVLSNNVPYTQPR 434 SEQIDNO:141 atggacaaatataccaacagggatcatccggactatattcctggcacatttaacatctat 60 tcttcccaaaatttggaaaatggtattatatacgaatcaaaattgaagaaaacctcctca 120 ggagtcgtcctaatccctcaaccatcatactcgccaaatgatccactgaactggtctagc 180 tggaggaaattggctcattttggtctaatggcctttataactgcgtttaccgccgctact 240 agtaacgacgctggtgctgctcaagactcattgaatgagatttatgggatatcctacgat 300 tccatgaacacaggggctggtgttcttttcctaggtattggttggtccactttattcttg 360 gctccatttgctaacttgtatggcaggaagattacgtacatagtttgcaccacattaggt 420 ctctttggtgcgctttggtttgctttggccaaaagaacgagcgacacaatatggtctcag 480 ttgtttgtaggtattagtgagtcctgtgctgaagcccaggtgcaactgtccctgagcgac 540 atttttttccagcaccaattgggctccgtattgaccgtgtatatcatgtgcactagtatc 600 ggtacgttcttgggcccattgatcgctgggtacatatctgcatttaccaacttccgttgg 660 gtcggttgggtcgcagtgatcatatctggtggccttttaataactattatatttggctgc 720 gaagaaacgtacttcgacagaggccagtatatgacccctttgaccagctgtcaatcggga 780 tacgaagacggtaccactttacaaaactctgacaatacggccgtgtcgcgcaggaaacgt 840 catcttgacgctaaattatcaactcctggagccatgggtgagaaaggtgtagacctttca 900 gagacggctgaattcgaagttaacaatgaagaggaagttaccatacctgagactcgcgaa 960 ttgattgatggttcaaaagagcatttgaaaccatacccaaaaagagtagcaatattaacc 1020 aaagctactaatttgaaaggctacggttttaaacagtatttcaaatatctaaagatcaac 1080 cttagaatgttcttattcccgccagtgtggttgtctggtatgttttggggtattcaagac 1140 gttttcctgacgttttatttgaccactcaagaaagcgcctactacgaacctccatggaac 1200 tatagtgattttggtgtcgcaattatgaatgttcccacacttattggagcagtcatcggt 1260 tgtatctgtgctggcattgttagtgactactttgttctttggatggctcgtcacaataga 1320 ggaattttagaggcagaatttagactatacttctctatcgcaactgcaattattgggcca 1380 gcgggtttgctgatgtttggtatcggtaccgctagacaatggccttggcaagctatatac 1440 gtcgggttgggttttgttgggtttgcatggggttgttctggtgatattgcgatggcgtat 1500 ttaatggattgttaccccgatatggttttggaaggtatggtttgtactgctattattaac 1560 aacacgatatcttgcattttcacctttacctgttctgattggctagctgcatctggtact 1620 gaaaatacttacattgctttagctgtcatcaactttgggattactgcatttgctttacca 1680 atgtactactatggtaagaggataagactttggactaagagatggtatttgcaatctgtc 1740 aatttgagagacggtgtgtaa 1761 SEQIDNO:142 MDKYTNRDHPDYIPGTFNIYSSQNLENGIIYESKLKKTSSGVVLIPQPSYSPNDPLNWSS 60 WRKLAHFGLMAFITAFTAATSNDAGAAQDSLNEIYGISYDSMNTGAGVLFLGIGWSTLFL 120 APFANLYGRKITYIVCTTLGLFGALWFALAKRTSDTIWSQLFVGISESCAEAQVQLSLSD 180 IFFQHQLGSVLTVYIMCTSIGTFLGPLIAGYISAFTNFRWVGWVAVIISGGLLITIIFGC 240 EETYFDRGQYMTPLTSCQSGYEDGTTLQNSDNTAVSRRKRHLDAKLSTPGAMGEKGVDLS 300 ETAEFEVNNEEEVTIPETRELIDGSKEHLKPYPKRVAILTKATNLKGYGFKQYFKYLKIN 360 LRMFLFPPVWLSGMFWGIQDVFLTFYLTTQESAYYEPPWNYSDFGVAIMNVPTLIGAVIG 420 CICAGIVSDYFVLWMARHNRGILEAEFRLYFSIATAIIGPAGLLMFGIGTARQWPWQAIY 480 VGLGFVGFAWGCSGDIAMAYLMDCYPDMVLEGMVCTAIINNTISCIFTFTCSDWLAASGT 540 ENTYIALAVINFGITAFALPMYYYGKRIRLWTKRWYLQSVNLRDGV 586 SEQIDNO:143 atgaccgaagactttatttcttctgtcaagcgttcaaatgaggagctgaaggagcgaaaa 60 tctaactttggatttgtagaatacaaatccaagcaattaacatcatcctcatcacacaat 120 tcaaactcatcgcatcacgatgatgacaaccaacacggcaagaggaatattttccagcga 180 tgtgttgattctttcaagtctcctctggacggctcgttcgacacaagtaatttgaagagg 240 actctgaaaccaaggcacttaatcatgattgccattgggggcagtataggtactggtttg 300 tttgtcggtagtggtaaggcaatcgccgaaggtggtcctcttggtgtcgtcattggttgg 360 gctattgcaggctctcaaatcatcgggacgattcatgggctaggtgaaatcacggtgcgg 420 ttccccgttgtcggggcctttgccaattacggcacaaggtttttggatccaagtataagt 480 tttgttgtttcgaccatatacgtgctacagtggttttttgtattacccttagaaatcatt 540 gcggcggcaatgaccgtacagtactggaactcgtctattgaccccgtaatttgggtagcc 600 atcttttatgctgttattgtttccataaatttgtttggtgtacgaggttttggggaagcg 660 gaatttgcattttccaccataaaagcaataacagtttgcggattcattatattgtgcgtt 720 gtcctcatttgcggtggaggtcccgaccacgagttcattggcgccaaatactggcacgac 780 cctggttgtttggccaatgggttcccgggcgttctatctgttcttgttgttgcttcgtat 840 tctctcggtggtatagaaatgacgtgcctggcatcaggtgaaacggaccccaaaggctta 900 ccaagtgctatcaagcaagtgttttggaggatcttatttttctttttgatatcactgacc 960 ctggtaggattcctggttccatatacaaaccaaaacttactgggtggttcatctgtggac 1020 aactcaccttttgtcattgccataaaattgcatcacattaaagccttgccctccatcgtc 1080 aatgcggtcatccttatcagtgttttgagtgtaggtaactcctgcatcttcgcttcaagt 1140 agaacgttgtgttcgatggcccaccaaggccttattccatggtggtttggttatatcgac 1200 cgtgctggtaggccactggttggcattatggcaaattcactatttggattactagcattt 1260 ctggtcaaatctggctcgatgtctgaagttttcaattggttaatggccattgccggcctg 1320 gccacgtgcattgtctggttgagcatcaacctgtcacatatcagatttagactggcgatg 1380 aaggctcaagggaagtctctggatgaattagaatttgttagtgctgtcgggatttgggga 1440 tcagcgtattccgctttaatcaactgtctaatcttgatagctcaattctattgttcacta 1500 tggcccattggtggctggaccagcggcaaagaaagggctaaaatattttttcaaaattat 1560 ctgtgtgccttaatcatgttatttatattcatcgtccacaaaatttattacaagtgtcaa 1620 acaggcaaatggtggggggttaaggcgttaaaggacatagatttggaaaccgatcgtaaa 1680 gatatcgacatcgaaatagtcaagcaagaaattgccgaaaagaaaatgtacctagattcc 1740 cgtccatggtacgtgagacagttccatttctggtgttaa 1779 SEQIDNO:144 MTEDFISSVKRSNEELKERKSNFGFVEYKSKQLTSSSSHNSNSSHHDDDNQHGKRNIFQR 60 CVDSFKSPLDGSFDTSNLKRTLKPRHLIMIAIGGSIGTGLFVGSGKAIAEGGPLGVVIGW 120 AIAGSQIIGTIHGLGEITVRFPVVGAFANYGTRFLDPSISFVVSTIYVLQWFFVLPLEII 180 AAAMTVQYWNSSIDPVIWVAIFYAVIVSINLFGVRGFGEAEFAFSTIKAITVCGFIILCV 240 VLICGGGPDHEFIGAKYWHDPGCLANGFPGVLSVLVVASYSLGGIEMTCLASGETDPKGL 300 PSAIKQVFWRILFFFLISLTLVGFLVPYTNQNLLGGSSVDNSPFVIAIKLHHIKALPSIV 360 NAVILISVLSVGNSCIFASSRTLCSMAHQGLIPWWFGYIDRAGRPLVGIMANSLFGLLAF 420 LVKSGSMSEVFNWLMAIAGLATCIVWLSINLSHIRFRLAMKAQGKSLDELEFVSAVGIWG 480 SAYSALINCLILIAQFYCSLWPIGGWTSGKERAKIFFQNYLCALIMLFIFIVHKIYYKCQ 540 TGKWWGVKALKDIDLETDRKDIDIEIVKQEIAEKKMYLDSRPWYVRQFHFWC 592 SEQIDNO:145 atgtcacagcaggagaatggtgatgtggccactgaattaatcgaaaatagactttccttc 60 tcaagaatccctagaataagccttcatgtaagggatttgtcaatcgttgcatccaaaaca 120 aatacgacgctagttaatacgttttccatggacctgcccagtgggtcggtcatggcagtt 180 atgggtggttcggggtcagggaagactacgttgctgaatgttctggcatccaagatcagt 240 ggtgggttaactcataatggttctatacggtacgtattggaagatacaggttcagaaccc 300 aatgaaacagagcctaagagggctcacttggatggccaagaccatcccatccagaaacac 360 gtaataatggcgtacctacctcaacaagatgtactctctcctaggttgacttgtagagaa 420 actcttaagtttgcagctgatttgaaactaaactcttctgagcgaaccaagaaattaatg 480 gtcgagcaattaattgaagaattagggctcaaggattgtgccgatactcttgtgggggac 540 aactcgcacaggggtctttctggtggtgaaaagagaagactaagtattggtactcaaatg 600 atttcaaacccttccatcatgttcttagatgagcctaccactggactggatgcatattct 660 gccttcttggttattaaaactttgaaaaaattagctaaagaagatggcaggacttttatc 720 atgtcaattcatcagccgagatcggatatattgtttttattggaccaggtttgtattttg 780 tcaaagggaaatgtggtatattgtgacaaaatggataatactatcccttattttgagtct 840 attggttatcacgtaccccagctggtaaatccagcagattatttcattgatttatcaagc 900 gtagactctagatctgataaagaagaagctgccacgcaaagtcggctaaattcattgatt 960 gatcattggcatgattatgagagaactcatttgcaactacaggcagaatcttatataagc 1020 aacgcaacggaaattcaaattcagaatatgactaccagactgccattttggaagcaagtt 1080 acggtgctaacaaggcgaaatttcaaattaaatttttcagattacgttactttaatatct 1140 acttttgcagaaccgttgattattggtactgtttgcggttggatttactataaacctgac 1200 aaaagcagtataggtggtttaaggacaacaaccgcatgtctttacgcgtccacaattttg 1260 caatgttacttgtatttgctttttgatacttatcgactttgtgagcaggatattgcgtta 1320 tatgacagagaaagagcagagggctcggtaacacctttggcattcatcgtagctagaaaa 1380 atttcacttttcctctctgacgatttcgcgatgaccatgatttttgtcagtataacatat 1440 tttatgtttggattggaagcagatgcaaggaagtttttttatcagtttgctgttgtattt 1500 ttatgtcagctatcatgttccggtttatctatgttatcggtggcggtatcgagagatttt 1560 tctaaagcttcattagtaggaaatatgacatttacggtattatcgatgggatgtggtttt 1620 ttcgttaatgctaaagtaatgcccgtgtatgttcgttggattaaatatattgcctttacg 1680 tggtattcattcggtactctcatgtcaagcacctttacgaattcgtactgtactacagat 1740 aatctcgatgagtgcttgggtaaccagatattggaagtttacgggtttcctaggaattgg 1800 ataaccgtacctgccgttgtcttactttgctggtctgtgggatattttgtagtaggtgca 1860 attattttatatttgcacaagattgatataactttacaaaatgaagtgaaatcgaagcaa 1920 aaaaaaatcaaaaagaaatccccaacaggaatgaaacccgagattcagctgctagatgac 1980 gtgtatcatcagaaagatttggaagcggagaaaggaaaaaatatacatattactataaaa 2040 ttagaagatatagacttacgagtcattttttctgcccctttctcaaactggaaagaaggc 2100 aacttccaccatgaaacaaaagaaattctacaatcagttaatgccattttcaaacctgga 2160 atgattaatgcaattatggggccatcagggtctggaaagtcttctctgttaaacctaatc 2220 tccggaagattaaaatcttcggtctttgccaaatttgacacttcaggttcaataatgttc 2280 aatgatattcaagtttcagagcttatgtttaaaaatgtatgctcgtatgtctcgcaggat 2340 gatgaccaccttttggcagctttaaccgttaaagaaaccctgaaatatgccgctgcatta 2400 agattgcatcatctgactgaggcagaacgaatggagagaactgacaacctaataaggtct 2460 ttgggtttaaagcattgtgaaaacaatatcattggtaatgaatttgttaaaggtataagc 2520 ggtggtgaaaaaagaagagtaactatgggtgtgcaattattaaacgatcctccgatatta 2580 ttgctagatgaaccaacttcagggttagatagcttcacatccgctactatactggaaatt 2640 ttggagaagttatgtagggaacagggcaagacgatcatcattaccattcatcaaccaagg 2700 tcagaattattcaagagatttggtaatgttttgctattagctaaatcgggtagaactgct 2760 ttcaatggatcaccagatgaaatgattgcttatttcactgaattgggatataactgtcct 2820 tcgtttacgaacgtggcagatttctttcttgatttaatttcagttaatacccagaacgaa 2880 cagaatgaaataagctcaagggcacgagtagaaaagatacttagtgcatggaaagctaat 2940 atggataacgaaagcctttcaccaaccccaatttctgaaaaacaacaatactctcaggag 3000 tcatttttcacagaatacagcgagtttgtaagaaaaccagctaatttggttttggcgtac 3060 atagtgaacgttaaaaggcaatttactacgacaaggagaagttttgactctttgatggcg 3120 cgtattgcacaaattccaggattaggtgttattttcgcattattctttgccccagtcaag 3180 cataattatacaagtattagcaatcgtctaggattggcacaagaatctacagcactatat 3240 tttgtgggcatgctggggaacttggcatgttatccaactgaaagagattacttttacgaa 3300 gaatataatgataatgtttatggtatagcaccttttttcttagcttatatgacattagag 3360 ttgccgctatccgcattagcttcagtgttatacgcggtatttacagtactggcatgtggg 3420 ttaccaagaactgcaggcaacttctttgcaaccgtctactgttcctttattgttacctgt 3480 tgtggcgaagctcttggtataatgacaaatacatttttcgaaaggccaggcttcgtcgtt 3540 aactgcatttccattattttatccattggtactcagatgtcagggttaatgtcactaggc 3600 atgtcgagagtattaaagggttttaactatttgaaccctgtagggtatacatctatgatc 3660 atcattaatttcgcattcccaggtaatttgaaattaacctgcgaagatggcgggaaaaat 3720 tcagacggtacttgtgaatttgcgaatggccatgatgtgttggtttcttatggtttagtc 3780 agaaatacgcaaaagtacctgggaatcattgtgtgcgtagccataatttatcgccttatt 3840 gcattttttattttaaaagcaaaattggagtggataaaatggtga 3885 SEQIDNO:146 MSQQENGDVATELIENRLSFSRIPRISLHVRDLSIVASKTNTTLVNTFSMDLPSGSVMAV 60 MGGSGSGKTTLLNVLASKISGGLTHNGSIRYVLEDTGSEPNETEPKRAHLDGQDHPIQKH 120 VIMAYLPQQDVLSPRLTCRETLKFAADLKLNSSERTKKLMVEQLIEELGLKDCADTLVGD 180 NSHRGLSGGEKRRLSIGTQMISNPSIMFLDEPTTGLDAYSAFLVIKTLKKLAKEDGRTFI 240 MSIHQPRSDILFLLDQVCILSKGNVVYCDKMDNTIPYFESIGYHVPQLVNPADYFIDLSS 300 VDSRSDKEEAATQSRLNSLIDHWHDYERTHLQLQAESYISNATEIQIQNMTTRLPFWKQV 360 TVLTRRNFKLNFSDYVTLISTFAEPLIIGTVCGWIYYKPDKSSIGGLRTTTACLYASTIL 420 QCYLYLLFDTYRLCEQDIALYDRERAEGSVTPLAFIVARKISLFLSDDFAMTMIFVSITY 480 FMFGLEADARKFFYQFAVVFLCQLSCSGLSMLSVAVSRDFSKASLVGNMTFTVLSMGCGF 540 FVNAKVMPVYVRWIKYIAFTWYSFGTLMSSTFTNSYCTTDNLDECLGNQILEVYGFPRNW 600 ITVPAVVLLCWSVGYFVVGAIILYLHKIDITLQNEVKSKQKKIKKKSPTGMKPEIQLLDD 660 VYHQKDLEAEKGKNIHITIKLEDIDLRVIFSAPFSNWKEGNFHHETKEILQSVNAIFKPG 720 MINAIMGPSGSGKSSLLNLISGRLKSSVFAKFDTSGSIMFNDIQVSELMFKNVCSYVSQD 780 DDHLLAALTVKETLKYAAALRLHHLTEAERMERTDNLIRSLGLKHCENNIIGNEFVKGIS 840 GGEKRRVTMGVQLLNDPPILLLDEPTSGLDSFTSATILEILEKLCREQGKTIIITIHQPR 900 SELFKRFGNVLLLAKSGRTAFNGSPDEMIAYFTELGYNCPSFTNVADFFLDLISVNTQNE 960 QNEISSRARVEKILSAWKANMDNESLSPTPISEKQQYSQESFFTEYSEFVRKPANLVLAY 1020 IVNVKRQFTTTRRSFDSLMARIAQIPGLGVIFALFFAPVKHNYTSISNRLGLAQESTALY 1080 FVGMLGNLACYPTERDYFYEEYNDNVYGIAPFFLAYMTLELPLSALASVLYAVFTVLACG 1140 LPRTAGNFFATVYCSFIVTCCGEALGIMTNTFFERPGFVVNCISIILSIGTQMSGLMSLG 1200 MSRVLKGFNYLNPVGYTSMIIINFAFPGNLKLTCEDGGKNSDGTCEFANGHDVLVSYGLV 1260 RNTQKYLGIIVCVAIIYRLIAFFILKAKLEWIKW 1294 SEQIDNO:147 atgcctctatcaaaggtggagcactacctttcataccatacgcgcttactcttaccccat 60 gttttgtctcttcagtcatcacatcgtgttgcatacatcttttcgctattatctgcggtg 120 tcaactggcttcattactttgatatctctttactctcaaccgtggcagaaacatttaaat 180 tattcctcatggcaaatcaacaccatcgctagtatgactaatttggggatgtacttgacg 240 ccaccaatcttggggatgatcgctgattctcatggccccattactttaagtcttttagcc 300 atcatagggttcatacctagctattcatatctggcttacgtttttaatcatccggagtta 360 tctctcggaggaaatggtgactcatcattcaatctatccatcatttgtttcgttttcata 420 ggtatatcaacaagcgctttatactttagcgctttactgacatgcactaagctatatcct 480 catacaaaactactatccattagcttaccaacgacatgttatggtatttcttctgtagtc 540 ggttctcaactgctaagaatcaaatggttctggtcctctaacgcaagttcttcctcgtcc 600 aatagtgacttaaacctgggaagagtattccaaacatttgccctcgtttatgtcgttatt 660 gggctacttgcatggatagccaccagcgtggtatcacttttgcattttaatgaagagcaa 720 gacaaccaaaaacggctggatgatcaaactgatgtggaacaatcaccgctgttagaacga 780 agtaatcatgttcaagaaaagtttacgcagacgatgctaaggatctttagtgatcctgtg 840 acatatatcctagcggtatcaattttgttatcacttgggcccctcgagatgtttattgcc 900 aatatgggatcactgactaacctgctagtccaattagatgcgccaaccttatctacaaag 960 ttgttatccacatacgcgctatcttccacttttacgagattgctcacaggcatagtggca 1020 gacttcttcgccaagaaaaaaatatcaattaaatggatcctgttgactttcctttcatta 1080 ggggtatgtgcacaactgtttttattgaaaatgacctcttcagcgtcaccctgggggcta 1140 gtacctacaggatcattggttggaattgtatacggtggacttttcactgtttatccgacg 1200 ctggtcctgttagtatggggcgaacgctcattcgggactgtttacggtagcttactaatt 1260 gcacctgctataggttctatgatattttgcatgttgtatgccaaattttacgattctcgc 1320 tgtatgagtggcggaggagatctgcgaaatccgtcctgtatttcggctgtctacaagtac 1380 agcagtatcgcattcgttgtatccgctgttctttcagctgtagtattttggaaattaaaa 1440 agtagaaaactcagaatttaa 1461 SEQIDNO:148 MPLSKVEHYLSYHTRLLLPHVLSLQSSHRVAYIFSLLSAVSTGFITLISLYSQPWQKHLN 60 YSSWQINTIASMTNLGMYLTPPILGMIADSHGPITLSLLAIIGFIPSYSYLAYVFNHPEL 120 SLGGNGDSSFNLSIICFVFIGISTSALYFSALLTCTKLYPHTKLLSISLPTTCYGISSVV 180 GSQLLRIKWFWSSNASSSSSNSDLNLGRVFQTFALVYVVIGLLAWIATSVVSLLHFNEEQ 240 DNQKRLDDQTDVEQSPLLERSNHVQEKFTQTMLRIFSDPVTYILAVSILLSLGPLEMFIA 300 NMGSLTNLLVQLDAPTLSTKLLSTYALSSTFTRLLTGIVADFFAKKKISIKWILLTFLSL 360 GVCAQLFLLKMTSSASPWGLVPTGSLVGIVYGGLFTVYPTLVLLVWGERSFGTVYGSLLI 420 APAIGSMIFCMLYAKFYDSRCMSGGGDLRNPSCISAVYKYSSIAFVVSAVLSAVVFWKLK 480 SRKLRI 486 SEQIDNO:149 atggatgcaactaccccactattaactgttgcgaacagtcatcccgcccgcaatccaaag 60 cacactgcatggagagcagctgtgtatgatttacagtatattttgaaagcgtcacccctg 120 aatttcctattggtatttgttcctttaggtctgatttggggacacttccaactatctcat 180 acactgacatttctttttaatttcttggcaattataccgttggcagctatcttggctaat 240 gccacggaagagttggctgataaggctggtaacaccattgggggactgctaaatgctact 300 tttggtaacgctgtggaactaattgtttctatcattgccctgaaaaaaggtcaagtgaga 360 attgtgcaggcctcgatgctaggtagtcttctttctaatttgctgttagtgcttggatta 420 tgcttcatattcggtggatacaatagagtccaacagacattcaaccaaaccgccgctcaa 480 acaatgtcctcattacttgccattgcgtgtgcatccctactgattcccgctgcctttaga 540 gccaccctacctcatggcaaggaagaccacttcatcgatggaaaaatattggagttatcc 600 agaggcacctctattgttattctcatcgtttacgttttgttcttatatttccagctaggg 660 agccatcacgccttgtttgagcaacaagaagaagagaccgatgaagttatgagcaccatt 720 tccaggaatccacatcactctttgagtgtcaagtcatcattggtgatacttctaggtaca 780 actgtgatcatctctttttgtgcggattttctagtcggtacgatagacaacgttgttgaa 840 tctaccgggctatctaaaacatttataggtttgattgtcattcctattgtgggtaatgcc 900 gcagagcatgtcacttcagtcttggtggccatgaaggataagatggatctggcgctaggt 960 gttgccatcggttcctctttacaagttgccttatttgttacaccattcatggttcttgtg 1020 ggctggatgatcgatgttccaatgacgctaaatttctccacttttgaaaccgctactctt 1080 tttattgctgttttcttatccaattacttaattctcgatggtgagtcaaactggttggag 1140 ggtgtcatgtctctagctatgtatattttgattgcaatggcatttttctattatccagac 1200 gaaaaaacccttgactctattggaaatagtttatga 1236 SEQIDNO:150 MDATTPLLTVANSHPARNPKHTAWRAAVYDLQYILKASPLNFLLVFVPLGLIWGHFQLSH 60 TLTFLFNFLAIIPLAAILANATEELADKAGNTIGGLLNATFGNAVELIVSIIALKKGQVR 120 IVQASMLGSLLSNLLLVLGLCFIFGGYNRVQQTFNQTAAQTMSSLLAIACASLLIPAAFR 180 ATLPHGKEDHFIDGKILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQEEETDEVMSTI 240 SRNPHHSLSVKSSLVILLGTTVIISFCADFLVGTIDNVVESTGLSKTFIGLIVIPIVGNA 300 AEHVTSVLVAMKDKMDLALGVAIGSSLQVALFVTPFMVLVGWMIDVPMTLNFSTFETATL 360 FIAVFLSNYLILDGESNWLEGVMSLAMYILIAMAFFYYPDEKTLDSIGNSL 411 SEQIDNO:151 atgaaggatttaaaattatcgaatttcaaaggcaaatttataagcagaaccagtcactgg 60 ggacttacgggtaagaagttgcggtatttcatcactatcgcatctatgacgggcttctcc 120 ctgtttggatacgaccaagggttgatggcaagtctaattactggtaaacagttcaactat 180 gaatttccagcaaccaaagaaaatggcgatcatgacagacacgcaactgtagtgcagggc 240 gctacaacctcctgttatgaattaggttgtttcgcaggttctctattcgttatgttctgc 300 ggtgaaagaattggtagaaaaccattaatcctgatgggttccgtaataaccatcattggt 360 gccgttatttctacatgcgcatttcgtggttactgggcattaggccagtttatcatcgga 420 agagtcgtcaccggtgttggaacagggttgaatacatctactattcccgtttggcaatca 480 gaaatgtcaaaagctgaaaatagagggttgctggtcaatttagaaggttccacaattgct 540 tttggtactatgattgcttattggattgattttgggttgtcttataccaacagttctgtt 600 cagtggagattccccgtgtcaatgcaaatcgtttttgctctcttcctgcttgctttcatg 660 attaaactacctgaatcgccacgttggctgatttctcaaagtcgaacagaagaagctcgc 720 tacttggtaggaacactagacgacgcggatccaaatgatgaggaagttataacagaagtt 780 gctatgcttcacgatgctgttaacaggaccaaacacgagaaacattcactgtcaagtttg 840 ttctccagaggcaggtcccaaaatcttcagagggctttgattgcagcttcaacgcaattt 900 ttccagcaatttactggttgtaacgctgccatatactactctactgtattattcaacaaa 960 acaattaaattagactatagattatcaatgatcataggtggggtcttcgcaacaatctac 1020 gccttatctactattggttcattttttctaattgaaaagctaggtagacgtaagctgttt 1080 ttattaggtgccacaggtcaagcagtttcattcacaattacatttgcatgcttggtcaaa 1140 gaaaataaagaaaacgcaagaggtgctgccgtcggcttatttttgttcattacattcttt 1200 ggtttgtctttgctatcattaccatggatatacccaccagaaattgcatcaatgaaagtt 1260 cgtgcatcaacaaacgctttctccacatgtactaattggttgtgtaactttgcggttgtc 1320 atgttcaccccaatatttattggacagtccggttggggttgctacttattttttgctgtt 1380 atgaattatttatacattccagttatcttctttttctaccctgaaaccgccggaagaagt 1440 ttggaggaaatcgacatcatctttgctaaagcatacgaggatggcactcaaccatggaga 1500 gttgctaaccatttgcccaagttatccctacaagaagtcgaagatcatgccaatgcattg 1560 ggctcttatgacgacgaaatggaaaaagaggactttggtgaagatagagtagaagacacc 1620 tataaccaaattaacggcgataattcgtctagttcttcaaacatcaaaaatgaagataca 1680 gtgaacgataaagcaaattttgagggttga 1710 SEQIDNO:152 MKDLKLSNFKGKFISRTSHWGLTGKKLRYFITIASMTGFSLFGYDQGLMASLITGKQFNY 60 EFPATKENGDHDRHATVVQGATTSCYELGCFAGSLFVMFCGERIGRKPLILMGSVITIIG 120 AVISTCAFRGYWALGQFIIGRVVTGVGTGLNTSTIPVWQSEMSKAENRGLLVNLEGSTIA 180 FGTMIAYWIDFGLSYTNSSVQWRFPVSMQIVFALFLLAFMIKLPESPRWLISQSRTEEAR 240 YLVGTLDDADPNDEEVITEVAMLHDAVNRTKHEKHSLSSLFSRGRSQNLQRALIAASTQF 300 FQQFTGCNAAIYYSTVLFNKTIKLDYRLSMIIGGVFATIYALSTIGSFFLIEKLGRRKLF 360 LLGATGQAVSFTITFACLVKENKENARGAAVGLFLFITFFGLSLLSLPWIYPPEIASMKV 420 RASTNAFSTCTNWLCNFAVVMFTPIFIGQSGWGCYLFFAVMNYLYIPVIFFFYPETAGRS 480 LEEIDIIFAKAYEDGTQPWRVANHLPKLSLQEVEDHANALGSYDDEMEKEDFGEDRVEDT 540 YNQINGDNSSSSSNIKNEDTVNDKANFEG 569 SEQIDNO:153 atgagtgacaatccatttaatgcgagtcttcttgacgaggactcaaaccgtgagagagaa 60 atactagatgccacagcagaggccctttcgaaaccaagcccttctttagagtattgtact 120 ttatccgtggacgaagctctagaaaaactggacactgacaaaaacggtggtttacgatca 180 tctaacgaggccaacaataggagatcactttatggccccaatgaaataaccgtagaagat 240 gatgaaagtcttttcaagaagttcttgtcaaatttcattgaggatcgaatgattctactt 300 ttaataggatccgcagtggtctctctttttatgggtaacattgatgatgctgttagtatc 360 acactggccattttcatagttgtcactgtcggttttgtccaagaatataggtctgaaaaa 420 tctctagaagcgttgaataaattggttcctgctgaatgtcacttaatgagatgtggtcaa 480 gagagtcatgtactggcttccaccttggttcctggtgatttagtgcacttcagaataggt 540 gacagaatccccgcagacattagaattattgaagcaatcgatttatccatcgatgaaagt 600 aatttaactggtgaaaatgaaccggtacataaaacctcacaaacgatcgaaaaatcttcc 660 tttaacgatcagcctaattcaattgtaccgatttctgagagatcttgtatagcttatatg 720 ggtacattagtcaaggaaggtcatggtaagggtatcgtcgtaggaacaggtacaaacaca 780 tcctttggtgccgtttttgaaatgatgaataatattgaaaaaccgaagactccattgcag 840 ttaacaatggacaaattgggaaaggacttgtcactggttagcttcatagttattggtatg 900 atttgtttagttggtatcatacaaggtagatcttggttagaaatgttccaaatatcggta 960 tccttagcggttgctgctattccagaagggttaccaattattgtcactgttactttggca 1020 ttgggtgttctgagaatggccaagcgtaaagccatcgtgagaaggttaccaagtgtcgaa 1080 actttaggctctgtcaacgttatctgctccgacaaaacaggtacactaacctcaaaccac 1140 atgaccgtatctaaactttggtgcttggacagtatgtccaataagctaaacgtcctctca 1200 ttagacaaaaataagaagactaaaaattctaatggaaatttgaaaaactatttgactgaa 1260 gacgttagggaaactctaactatcggtaatctctgtaataatgcatctttctctcaagaa 1320 catgccatatttctgggaaatcctactgatgtagctcttttagagcaattggcaaacttt 1380 gaaatgcctgatatcagaaacaccgttcaaaaagttcaggaacttccatttaactcgaaa 1440 agaaaattaatggcaaccaagattctcaaccctgtcgacaataagtgtacagtttatgtt 1500 aaaggtgcatttgaaagaattcttgagtactccacaagttatttgaaatcaaagggtaaa 1560 aaaactgaaaagttgactgaagcccaaaaagctacgataaatgagtgcgcaaattctatg 1620 gcatctgaaggtttgcgtgtctttggatttgctaaactaactttgtctgattcatcaact 1680 cctctaaccgaagacctaatcaaagatttaacctttactggtttaatcggtatgaatgac 1740 ccaccaagaccgaacgttaaatttgccatcgaacaattactacaaggtggtgtccatatt 1800 attatgatcactggtgattctgagaataccgcagtaaacattgcaaaacaaattggtatt 1860 ccagttattgatccaaagctttccgttttatccggtgataaattagatgaaatgtcagat 1920 gatcaactggccaatgtcatcgaccacgttaatatttttgctcgtgctacgcctgagcat 1980 aagttaaacattgttcgtgcattaagaaagaggggtgatgtggtagcaatgactggtgat 2040 ggtgttaacgacgctcctgcgttgaaactttcagatattggtgtttctatgggtagaatt 2100 ggtacagatgtagccaaagaagcctcagatatggtcttaactgatgatgacttcagtact 2160 attttaactgccattgaagagggtaaaggtatctttaataatattcagaatttcctgact 2220 tttcaattgtctacttctgttgccgcactatcattagttgcactatctacagcgtttaaa 2280 ctacccaatccactgaacgcaatgcaaattctttggataaatattttaatggatgggcca 2340 ccagctcaatccttaggtgtggaacctgttgatcatgaagttatgaaaaaacctccaaga 2400 aaacgtaccgataaaattttgacccatgatgtaatgaaacgtttactaaccaccgcggcc 2460 tgtatcatcgttgggacagtttacatttttgttaaagagatggccgaagatggtaaagta 2520 actgctagagatactactatgacatttacttgttttgttttttttgatatgtttaatgct 2580 ttggcctgcagacataacacaaagtcaatcttcgaaatcggctttttcacgaacaaaatg 2640 ttcaactacgccgttggactgtctctgttaggtcaaatgtgcgctatatatataccattt 2700 ttccaaagtatctttaaaactgagaaacttggtatctctgatatactattgttattgctc 2760 atcagcagtagcgttttcatcgttgatgaattgagaaaattgtggacgaggaaaaagaat 2820 gaagaagactcaacgtatttctcaaatgtttga 2853 SEQIDNO:154 MSDNPFNASLLDEDSNREREILDATAEALSKPSPSLEYCTLSVDEALEKLDTDKNGGLRS 60 SNEANNRRSLYGPNEITVEDDESLFKKFLSNFIEDRMILLLIGSAVVSLFMGNIDDAVSI 120 TLAIFIVVTVGFVQEYRSEKSLEALNKLVPAECHLMRCGQESHVLASTLVPGDLVHFRIG 180 DRIPADIRIIEAIDLSIDESNLTGENEPVHKTSQTIEKSSFNDQPNSIVPISERSCIAYM 240 GTLVKEGHGKGIVVGTGTNTSFGAVFEMMNNIEKPKTPLQLTMDKLGKDLSLVSFIVIGM 300 ICLVGIIQGRSWLEMFQISVSLAVAAIPEGLPIIVTVTLALGVLRMAKRKAIVRRLPSVE 360 TLGSVNVICSDKTGTLTSNHMTVSKLWCLDSMSNKLNVLSLDKNKKTKNSNGNLKNYLTE 420 DVRETLTIGNLCNNASFSQEHAIFLGNPTDVALLEQLANFEMPDIRNTVQKVQELPFNSK 480 RKLMATKILNPVDNKCTVYVKGAFERILEYSTSYLKSKGKKTEKLTEAQKATINECANSM 540 ASEGLRVFGFAKLTLSDSSTPLTEDLIKDLTFTGLIGMNDPPRPNVKFAIEQLLQGGVHI 600 IMITGDSENTAVNIAKQIGIPVIDPKLSVLSGDKLDEMSDDQLANVIDHVNIFARATPEH 660 KLNIVRALRKRGDVVAMTGDGVNDAPALKLSDIGVSMGRIGTDVAKEASDMVLTDDDFST 720 ILTAIEEGKGIFNNIQNFLTFQLSTSVAALSLVALSTAFKLPNPLNAMQILWINILMDGP 780 PAQSLGVEPVDHEVMKKPPRKRTDKILTHDVMKRLLTTAACIIVGTVYIFVKEMAEDGKV 840 TARDTTMTFTCFVFFDMFNALACRHNTKSIFEIGFFTNKMFNYAVGLSLLGQMCAIYIPF 900 FQSIFKTEKLGISDILLLLLISSSVFIVDELRKLWTRKKNEEDSTYFSNV 950 SEQIDNO:155 atgaatggaaaagaggtttcaagtggctctggaagaacgcagagcaacaacaacaaaaaa 60 aataacaacggaggcagtacaggaatctcgcatgcgtctggctcacctttaacggacggc 120 aacggtggcaatagcaacggtaatagtagaagtagaagcagaagtagaaaatctagtgga 180 actacaggtggtttgctaaaaaagccgccgctgcttgtgaacaatgaagcggtgcatgct 240 agcgtacccgacgcgtcgcacacttcctgtaacaatggcacgcttgaagtgagcataaat 300 aaccctgagccacatgtggtagatgccgtggcacgccacttgataagaaacccgagtaac 360 agcctacaattgcaaggcggagacattacaagagatctgtataagtggacaaacgaccat 420 ccttcatcaccatcgcagtatcagtacccaagtcaacctgcactttccacctcaatacct 480 tcacaagcgccctcattctcgaatcgtaaaaggtctatgagcttttctgccgcttctata 540 gcatcttcctctcaccttaacaacaactcggaggcgaatgggaatcctctagcggcaata 600 ggcctggcgcccgcaccgatgacgcacgaagaaatcagggctcctggtggattcagaaga 660 tcttttataatacagaagcgcaggaaacataacgttgatgcgcccataccgaattttttc 720 accaggaactttattgaatttttgaccttgtatggccacttcgctggtgaagatttatcg 780 gaagaagaggaggaggaggaagaaactgaagaggagccagaggaggaagctttggaaacg 840 gaaagcacccagctagtttctcgtgaacacgggcgccatcctcacaaatcatctacggta 900 aaggcggtgctgctcttgttaaagtcatttgttgggacaggtgtgcttttcctaccaaag 960 gctttccataacggtggttggggatttagcgccctttgtctactctcgtgtgccctcatt 1020 tcttatggatgtttcgtatcattgattaccaccaaggacaaagtaggcgtagatgggtac 1080 ggtgacatgggtcgtatactatatgggcccaaaatgaaatttgccattctttcgtctatc 1140 gccttgtcacaaatcgggttttctgctgcatacactgttttcactgcaactaatttgcag 1200 gtcttttctgaaaatttcttccatttgaaaccgggcagcatcagtctagccacctatatc 1260 tttgcacaagtactcatctttgtcccactatctttgacaagaaacatagccaagttaagt 1320 gggaccgcgttaatagcagatctatttattctactgggattggtttatgtttacgtttac 1380 tccatttattatattgctgttaatggtgtcgcatccgatacaatgcttatgttcaataaa 1440 gcggactggtcgttgttcatcggtaccgccatattcacctttgaaggtataggcctactt 1500 atccccattcaggagtcaatgaaacacccgaagcatttccggccatcgttgtccgcggtg 1560 atgtgtatcgtggcagtgattttcatatcatgtggtctcttatgctatgccgcttttgga 1620 tctgacgtgaaaactgttgttttattgaattttccgcaggacacttcctatactctcact 1680 gttcaattactgtatgcattagccattttgttatccacgccgttgcagctatttcccgcg 1740 atacgtattttggaaaactggacttttccctcaaatgcatctggtaaatacaacccgaaa 1800 gtcaaatggttgaaaaactatttccgttgcgctattgtcgtcctgacatctatcctcgct 1860 tgggtaggcgccaacgatttggacaaatttgtatcactggtaggctccttcgcgtgtatc 1920 ccattgatctacatatacccgccattgttgcactataaggcgtccatcttatctggaacc 1980 tcgagagccaggcttcttttagatttaatcgtcatagtatttggagttgctgtcatggcc 2040 tacacgtcatggcagacgattaaaatgtggagccagtaa 2079 SEQIDNO:156 MNGKEVSSGSGRTQSNNNKKNNNGGSTGISHASGSPLTDGNGGNSNGNSRSRSRSRKSSG 60 TTGGLLKKPPLLVNNEAVHASVPDASHTSCNNGTLEVSINNPEPHVVDAVARHLIRNPSN 120 SLQLQGGDITRDLYKWTNDHPSSPSQYQYPSQPALSTSIPSQAPSFSNRKRSMSFSAASI 180 ASSSHLNNNSEANGNPLAAIGLAPAPMTHEEIRAPGGFRRSFIIQKRRKHNVDAPIPNFF 240 TRNFIEFLTLYGHFAGEDLSEEEEEEEETEEEPEEEALETESTQLVSREHGRHPHKSSTV 300 KAVLLLLKSFVGTGVLFLPKAFHNGGWGFSALCLLSCALISYGCFVSLITTKDKVGVDGY 360 GDMGRILYGPKMKFAILSSIALSQIGFSAAYTVFTATNLQVFSENFFHLKPGSISLATYI 420 FAQVLIFVPLSLTRNIAKLSGTALIADLFILLGLVYVYVYSIYYIAVNGVASDTMLMFNK 480 ADWSLFIGTAIFTFEGIGLLIPIQESMKHPKHFRPSLSAVMCIVAVIFISCGLLCYAAFG 540 SDVKTVVLLNFPQDTSYTLTVQLLYALAILLSTPLQLFPAIRILENWTFPSNASGKYNPK 600 VKWLKNYFRCAIVVLTSILAWVGANDLDKFVSLVGSFACIPLIYIYPPLLHYKASILSGT 660 SRARLLLDLIVIVFGVAVMAYTSWQTIKMWSQ 692 SEQIDNO:157 atgagtaatacttcttcgtacgagaagaataatccagataatctgaaacacaatggtatt 60 accatagattctgagtttctaactcaggagccaataaccattccctcaaatggctccgct 120 gtttctattgacgaaacaggttcagggtccaaatggcaagactttaaagattctttcaaa 180 agggtaaaacctattgaagttgatcctaatctttcagaagctgaaaaagtggctatcatc 240 actgcccaaactccattgaagcaccacttgaagaatagacatttgcaaatgattgccatc 300 ggtggtgccatcggtactggtctgctggttgggtcaggtactgcactaagaacaggtggt 360 cccgcttcgctactgattggatgggggtctacaggtaccatgatttacgctatggttatg 420 gctctgggtgagttggctgttatcttccctatttcgggtgggttcaccacgtacgctacc 480 agatttattgatgagtcctttggttacgctaataatttcaattatatgttacaatggttg 540 gttgtgctaccattggaaattgtctctgcatctattactgtaaatttctggggtacagat 600 ccaaagtatagagatgggtttgttgcgttgttttggcttgcaattgttatcatcaatatg 660 tttggtgtcaaaggttatggtgaagcagaattcgtcttttcatttatcaaggtcatcact 720 gttgttgggttcatcatcttaggtatcattctaaactgtggtggtggtccaacaggtggt 780 tacattgggggcaagtactggcatgatcctggtgcctttgctggtgacactccaggtgct 840 aaattcaaaggtgtttgttctgtcttcgtcaccgctgccttttcttttgccggttcagaa 900 ttggttggtcttgctgccagtgaatccgtagagcctagaaagtccgttcctaaggctgct 960 aaacaagttttctggagaatcaccctattttatattctgtcgctattaatgattggtctt 1020 ttagtcccatacaacgataaaagtttgattggtgcctcctctgtggatgctgctgcttca 1080 cccttcgtcattgccattaagactcacggtatcaagggtttgccaagtgttgtcaacgtc 1140 gttatcttgattgccgtgttatctgtcggtaactctgccatttatgcatgttccagaaca 1200 atggttgccctagctgaacagagatttctgccagaaatcttttcctacgttgaccgtaag 1260 ggtagaccattggtgggaattgctgtcacatctgcattcggtcttattgcgtttgttgcc 1320 gcctccaaaaaggaaggtgaagttttcaactggttactagccttgtctgggttgtcatct 1380 ctattcacatggggtggtatctgtatttgtcacattcgtttcagaaaggcattggccgcc 1440 caaggaagaggcttggatgaattgtctttcaagtctcctaccggtgtttggggttcctac 1500 tgggggttatttatggttattattatgttcattgcccaattctacgttgctgtattcccc 1560 gtgggagattctccaagtgcggaaggtttcttcgaagcttatctatccttcccacttgtt 1620 atggttatgtacatcggacacaagatctataagaggaattggaagcttttcatcccagca 1680 gaaaagatggacattgatacgggtagaagagaagtcgatttagatttgttgaaacaagaa 1740 attgcagaagaaaaggcaattatggccacaaagccaagatggtatagaatctggaatttc 1800 tggtgttaa 1809 SEQIDNO:158 MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFK 60 RVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGG 120 PASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWL 180 VVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVIT 240 VVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSE 300 LVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAAS 360 PFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRK 420 GRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAA 480 QGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLV 540 MVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNF 600 WC 602 SEQIDNO:159 atggtgaacgttggtccttctcatgctgcagttgctgtggatgctagcgaagcccgcaaa 60 agaaatatttcagaagaagtattcgaactgagggataagaaagattctacagtggtaatt 120 gagggtgaagccccggtaagaacttttaccagtagctctagtaaccatgaaagagaggat 180 acgtatgtttctaaaaggcaggtaatgagagatatttttgctaaatacttgaagttcatt 240 ggacctggattgatggttagtgtggcttacatcgatcccggtaattactctactgccgtc 300 gatgcaggtgcctctaatcaattttccctactttgtatcattttgttatcaaactttatt 360 gccatatttttgcaatgtctgtgtatcaagttgggttccgttacgggactagatctaagt 420 cgagcttgcagagagtatttaccacggtggctcaactggacattgtatttttttgcagaa 480 tgtgccgttatagccaccgatatagctgaagtgattggtacagcgattgccttgaatatc 540 ctgatcaaagtgccccttccagcgggcgtggccattactgttgtggatgtgtttttgatt 600 atgtttacatataaacctggtgcgtcatcaattaggttcattagaatatttgaatgtttt 660 gttgcagtattagttgttggcgtgtgcatttgtttcgcaatagaattggcttatatcccg 720 aagagtacgtccgttaaacaagtgttcagaggatttgtgccatctgcccaaatgtttgac 780 cacaatggtatttataccgctatttccatcttaggtgctactgttatgccacattcgttg 840 tttttgggttccgctttagtgcagccaaggcttttagattatgacgttaaacacggtaat 900 tatactgtttctgaagaacaagataaagtgaaaaaatctaaatccactgaagagattatg 960 gaagaaaaatattttaattatagacccacgaacgctgctatcaaatattgcatgaaatat 1020 tctatggtcgaattaagcataactctcttcaccctagcgcttttcgtcaattgtgccatc 1080 ctagttgttgcgggctccactctatataactcaccagaagcagatggggcagatttgttt 1140 actattcatgaattattatcaagaaatctggcacccgcagcaggtacgattttcatgctc 1200 gcacttttattaagtggtcaatccgcaggtgtagtgtgtactatgtcgggtcaaattgta 1260 agtgagggtcatattaattggaagttgcagccatggcaaagaagattggccactagatgt 1320 atttcgataatcccttgtttggtcatctctatctgtatcggtagagaagctttatcaaag 1380 gccttaaatgcttcccaagttgttttatccatagttctgccatttttggtagcaccttta 1440 attttcttcacatgtaaaaaatcaatcatgaaaaccgaaattaccgtcgaccatactgaa 1500 gaagatagccataaccatcaaaataacaacgatagatctgcaggtagcgtaatcgagcaa 1560 gatggttctagtggcatggagatagaaaatggaaaagatgtcaaaatcgtttatatggca 1620 aacaattggattatcactgttattgctataattgtgtggcttttcttatctttactgaac 1680 gtttatgccattgttcaattaggcatgtctcatggtgatatcagttaa 1728 SEQIDNO:160 MVNVGPSHAAVAVDASEARKRNISEEVFELRDKKDSTVVIEGEAPVRTFTSSSSNHERED 60 TYVSKRQVMRDIFAKYLKFIGPGLMVSVAYIDPGNYSTAVDAGASNQFSLLCIILLSNFI 120 AIFLQCLCIKLGSVTGLDLSRACREYLPRWLNWTLYFFAECAVIATDIAEVIGTAIALNI 180 LIKVPLPAGVAITVVDVFLIMFTYKPGASSIRFIRIFECFVAVLVVGVCICFAIELAYIP 240 KSTSVKQVFRGFVPSAQMFDHNGIYTAISILGATVMPHSLFLGSALVQPRLLDYDVKHGN 300 YTVSEEQDKVKKSKSTEEIMEEKYFNYRPTNAAIKYCMKYSMVELSITLFTLALFVNCAI 360 LVVAGSTLYNSPEADGADLFTIHELLSRNLAPAAGTIFMLALLLSGQSAGVVCTMSGQIV 420 SEGHINWKLQPWQRRLATRCISIIPCLVISICIGREALSKALNASQVVLSIVLPFLVAPL 480 IFFTCKKSIMKTEITVDHTEEDSHNHQNNNDRSAGSVIEQDGSSGMEIENGKDVKIVYMA 540 NNWIITVIAIIVWLFLSLLNVYAIVQLGMSHGDIS 575 SEQIDNO:161 atggcagaagtactgaccgtcctcgagcagccgaactcaattaaagattttctcaagcag 60 gattcaaatattgcgtttctagctggtggagtagctggcgcggtttcccgaaccgttgtt 120 tcaccttttgagagagttaaaatactgctgcaagttcaaagttcaaccacttcttataac 180 cgaggtatctttagctctatacggcaggtttaccatgaggagggaaccaaaggtttattc 240 agaggaaatggtttgaactgcataagaatttttccctatagtgcagtccagtttgtagta 300 tacgaagcttgtaagaaaaagttattccatgtaaatggcaataatggacaagaacaacta 360 acgaacacccaaagactattcagtggtgcattgtgtggtggttgtagtgtggtggctact 420 tacccgttggacttgatcaaaacaagactatcgattcagacagcaaatttgagcagttta 480 aaccgctcaaaggcaaaaagtatatcaaagcctccggggatctggcaattactaagcgaa 540 acttacagactcgaaggcggtctcaggggattatataggggtgtatggccaacgagtctt 600 ggtgttgttccatatgtagcactaaactttgcagtttacgaacaattgagagaattcggt 660 gtcaattcctccgatgctcagccttcctggaaaagtaacctctataaattaacaattggc 720 gccataagtggaggggttgcgcaaacaatcacttatccctttgatctgctaagaagaaga 780 tttcaagttctcgcaatgggcggaaatgaactgggatttagatacacgagtgtctgggat 840 gcgctcgtgacaatcggcagagcagaaggcgttagcggttactacaaaggcttagctgca 900 aacctttttaaagttgttccttcaactgcagtgagttggctagtttacgaagttgtatgt 960 gattctgtaagaaattggtga 981 SEQIDNO:162 MAEVLTVLEQPNSIKDFLKQDSNIAFLAGGVAGAVSRTVVSPFERVKILLQVQSSTTSYN 60 RGIFSSIRQVYHEEGTKGLFRGNGLNCIRIFPYSAVQFVVYEACKKKLFHVNGNNGQEQL 120 TNTQRLFSGALCGGCSVVATYPLDLIKTRLSIQTANLSSLNRSKAKSISKPPGIWQLLSE 180 TYRLEGGLRGLYRGVWPTSLGVVPYVALNFAVYEQLREFGVNSSDAQPSWKSNLYKLTIG 240 AISGGVAQTITYPFDLLRRRFQVLAMGGNELGFRYTSVWDALVTIGRAEGVSGYYKGLAA 300 NLFKVVPSTAVSWLVYEVVCDSVRNW 326 SEQIDNO:163 atgttttcacttagttcgctatctagcagcggtgggcattcagagcagaaggaaagagag 60 agaataagttattttgatattagaataaactccccgtacaaggacataattttgatccaa 120 gggtcaccgttggaactgtcgtctatacctttatcaggaaacttagtgatttcagtgaaa 180 aatgagatcgtagtgaagaaaatttcgctgagattggtaggaagattcaaattggagttt 240 ttgcaagttggccgatataagaagaatagcagtagtttggcaagtctagttaaggaaaag 300 cgtaagattttcgaatgctattgggacaacttattggtttcttcaaaaggggatgtttta 360 gtcggtggggaaaatgcggaaaatcaacataacagtagtagcggtcgcagtacaagcaac 420 caagatatggacaccagcggcaacgcaatatttctaagcaagagatcactttcgagccct 480 gttttcaacaaaataattcgaagaaagacccattcttcccacagaaaaatactagagcta 540 ccagaaaatggtgttacaggaacccctttcgagggtttaagagaaaacgcccgtagtaga 600 agcagtagtagtaacaccctcaataacaatagccatagttatagtaacagagacgggtct 660 ggaagttcgtacttattcctaatgaaaagaggcaactacgaactacccttcaatacaatg 720 ctccccccagaagtgtgcgaaacaatcgagggactacaaagtggtagcatactgtattcc 780 tttgaagccattatagatggacgtcagttatgggatactgatctgagcgttcatacttct 840 cctcacggtccaatcggtagcacaagtacgagcggcaatggtatgagaacgaagaataaa 900 attatcatcaaaaagttcaagtatctcagaatccttcgtacattatcgatggacaatctt 960 gccatgcaagaagaaattagcgtgggtaatacttggcgtgacaagttgcaatacgaaacg 1020 tccatcccgagtagggctgttcctattggtagcacaacccccgtgaagattaagattttc 1080 cccttcgaaaagaacattcgtttggataggatagaaatggcgctaatccaatattacgca 1140 atgaaggacagcagcgcacaaatttatgatgatgaaatagccgtcatgaaaattactcat 1200 ctagcggacttcggcccgctgacggacaaacttgacgtcgattgtccctttacaattcca 1260 gataacctcaaacaaataactcaagactgctgtctgcaagacaacctaatccgtgtcatg 1320 cacaaattgcaggtacgtattcttttacaacgtcaagtggatggcgaatacaagaacctg 1380 gagatcaaggcgcaattacctatgttattatttatttcgccgcatctgcctatgaaaggc 1440 cgtctagtgttgtttgataaacacgatggcaagatccacttccgccctggcgaattagta 1500 cccctttttttaaccacttaccccgcgcagggtctgactccaggcgttgaactgaactcc 1560 actacaacggcgcacctcgcgctgccacaaccgccaccgaattatcacgagagcaccaac 1620 gatcatctcatgccggcgctacagccgctcggcgccgattcggtggtactgacagtgccg 1680 tcatacgagcaggcgcaggcgcaggcatcggcatcgtcttacgtgacagggtccgtaccc 1740 gcttactgcgacgatgactga 1761 SEQIDNO:164 MFSLSSLSSSGGHSEQKERERISYFDIRINSPYKDIILIQGSPLELSSIPLSGNLVISVK 60 NEIVVKKISLRLVGRFKLEFLQVGRYKKNSSSLASLVKEKRKIFECYWDNLLVSSKGDVL 120 VGGENAENQHNSSSGRSTSNQDMDTSGNAIFLSKRSLSSPVFNKIIRRKTHSSHRKILEL 180 PENGVTGTPFEGLRENARSRSSSSNTLNNNSHSYSNRDGSGSSYLFLMKRGNYELPFNTM 240 LPPEVCETIEGLQSGSILYSFEAIIDGRQLWDTDLSVHTSPHGPIGSTSTSGNGMRTKNK 300 IIIKKFKYLRILRTLSMDNLAMQEEISVGNTWRDKLQYETSIPSRAVPIGSTTPVKIKIF 360 PFEKNIRLDRIEMALIQYYAMKDSSAQIYDDEIAVMKITHLADFGPLTDKLDVDCPFTIP 420 DNLKQITQDCCLQDNLIRVMHKLQVRILLQRQVDGEYKNLEIKAQLPMLLFISPHLPMKG 480 RLVLFDKHDGKIHFRPGELVPLFLTTYPAQGLTPGVELNSTTTAHLALPQPPPNYHESTN 540 DHLMPALQPLGADSVVLTVPSYEQAQAQASASSYVTGSVPAYCDDD 586 SEQIDNO:165 atgtcgttactgagactgtggaacaaagaatcaagggcaccatcaaaaataaagagtcat 60 ggtattgttggcagttacggcaacagcatgctggcccataacaacgtgaagcaatttcgt 120 atagacatagacgaaccgcatagagtatggaaaccgaatgaaagcataaccggagaagcg 180 gtcattgacataaagagagacataactaacgtagcgatcaaattatcgctagtatgtgag 240 gttcgcgtgaaaacggggaacagtccaacctccaagaataagagaattgagaaaacctta 300 gagaagtcgacgtttctttatggacaggactacgtaaagacagctttttcggctaaggaa 360 aagaaaccgcatgttgacaaaaccaccattctcaatggtttaagcaagggggaacacagg 420 tttccctttaggatacgaataccacgaggcagaggaatgttgagctctataaagttcgaa 480 aggggctcgataacatacttcctctcttgcactttagaatccctcaacaacatcaacgga 540 ttaaaaaaaccggaagcaagatgcgaacgtgagtttgcagtcatagttccgctggacgtc 600 tcgaggctgcccaagccgaaaactaagacagtggttttacaatcagcatctatggtccaa 660 aacaaaaagaacaaatctacagaggacgaatcctcatcgtatacacaattaactcaaaag 720 tctactacttctaattcttctagcagttcagtaaactccaagacgtcccccttaccaaat 780 aaaacggtgactatatccgtagacataccgcaggctggattcatgattggtgaaattatc 840 cctatagacgttaagattgaccactataagcctttctatgcccctgcgggtctcaccacc 900 actttggtgaggatatgtagggtgggcggtgcaggcaaagatgatcctatggagactttc 960 agaaaagatatatgtcagagtatctctcctatatatattaaccctgaaacgttgcagttt 1020 caatctagagtttatctgaaagtgccccttgatgcattttcgacccttactactgtggga 1080 aaatttttctccttccaatactatatcgaggttatggttaacttatcaaaaaaaaacgtg 1140 gtttacacagaatctaatagaataataggaactcctattggagaacaaaatggcttgggc 1200 gtagagaataatatcaaccgtatccaaaggaaaatgctacgtatggtcaatccagaaacg 1260 ttggagaacgattctgagggttatgaatccagtatatttttcaaagatatggtaaatgtg 1320 gaaaagctaaagagactgaggaatgtaactggtatgtccatagaaaccgtcataggaacg 1380 acgagatccgaacagcagcaatctgatgcaagcatcccatcccaatcctcaatcacggct 1440 cctcaaaattctccatcgaatttaagagattggttggccccattaaatgcatatgatagt 1500 gacgatgttccagttccaaagtattcgccaaatgataaagtcagtgtaccgtcggaagac 1560 aaacaagaacttgaacaaaaaagactacaacagttagaaagcgatcctcccccttgtgat 1620 gactattaa 1629 SEQIDNO:166 MSLLRLWNKESRAPSKIKSHGIVGSYGNSMLAHNNVKQFRIDIDEPHRVWKPNESITGEA 60 VIDIKRDITNVAIKLSLVCEVRVKTGNSPTSKNKRIEKTLEKSTFLYGQDYVKTAFSAKE 120 KKPHVDKTTILNGLSKGEHRFPFRIRIPRGRGMLSSIKFERGSITYFLSCTLESLNNING 180 LKKPEARCEREFAVIVPLDVSRLPKPKTKTVVLQSASMVQNKKNKSTEDESSSYTQLTQK 240 STTSNSSSSSVNSKTSPLPNKTVTISVDIPQAGFMIGEIIPIDVKIDHYKPFYAPAGLTT 300 TLVRICRVGGAGKDDPMETFRKDICQSISPIYINPETLQFQSRVYLKVPLDAFSTLTTVG 360 KFFSFQYYIEVMVNLSKKNVVYTESNRIIGTPIGEQNGLGVENNINRIQRKMLRMVNPET 420 LENDSEGYESSIFFKDMVNVEKLKRLRNVTGMSIETVIGTTRSEQQQSDASIPSQSSITA 480 PQNSPSNLRDWLAPLNAYDSDDVPVPKYSPNDKVSVPSEDKQELEQKRLQQLESDPPPCD 540 DY 542 SEQIDNO:167 atgccagagcaagaactacttatagggcaagaaatgaatacacttcatgcaggttcatct 60 actgatggcataaatgtcggaaacgcaggacgaactagagacacacaaactggcgtagaa 120 ggggaaacggaaatagggtctgacgaggaagatagcatagaggacgagggaagcagcagt 180 ggaggaaatagtacgacagaaagactagtaccacaccagctgagggaacaagcagccaga 240 catataggaaaaataggaagacattttaatattcttgatagactttttaagaaacgtaca 300 caacagtcttcggatatacaacaaggtgccatgtttgatggtgtctttagcaatttaagc 360 gcaaaaccagataccacagagactgaaggtaataacgaacaagacataccacctacatac 420 gacgaagctgctgctgatatggccccctcgtattatggaatggatttgaacaattcagat 480 atctactacgacgaaatatgcattgaggggcttcctgtaggaaatatagcaaatttatta 540 tggaatatcatcgtaagcacgagttttcagttcattggatttttaataacctacatttta 600 cacacatctcacgcagcaaagcaaggttcaaggtttggattagggttaacgttcattgga 660 tatggttattcaatgattcccaatgatgttacttcaaaagtcggcaaaaataaaagctta 720 aatagaatggaattagaggatccaaatgaattcgatgatgttcgtctaaattcacaatca 780 acgacacaagataaatttgaatcacatttgaatcacggtctggatgaagaaaaacaaaac 840 ataccatggttggctgtttttgtggcatttcttgggctatttatcaccctgaagagtata 900 tacgactacattcaagtcaaaaaattggaaaagaaatacctcaaccaaagtcaaaatcaa 960 gcataa 966 SEQIDNO:168 MPEQELLIGQEMNTLHAGSSTDGINVGNAGRTRDTQTGVEGETEIGSDEEDSIEDEGSSS 60 GGNSTTERLVPHQLREQAARHIGKIGRHFNILDRLFKKRTQQSSDIQQGAMFDGVFSNLS 120 AKPDTTETEGNNEQDIPPTYDEAAADMAPSYYGMDLNNSDIYYDEICIEGLPVGNIANLL 180 WNIIVSTSFQFIGFLITYILHTSHAAKQGSRFGLGLTFIGYGYSMIPNDVTSKVGKNKSL 240 NRMELEDPNEFDDVRLNSQSTTQDKFESHLNHGLDEEKQNIPWLAVFVAFLGLFITLKSI 300 YDYIQVKKLEKKYLNQSQNQA 321 SEQIDNO:169 atgtcattcaagtttctgatagaatcgctgcttctcggttcgataagcggacaaatacgg 60 tgtggtagatcttcggtgatcccccgtggcgatgtatcttatgggggagacgatactgac 120 gaacttaacatggatataatgttgtttgcgtttggaaccttaatcgtggtctacatcgtc 180 atctgtatcgtttatttttttacaaaacagatagctacgcggcttataactgcatattat 240 aatgagcatggccctggccaaagaatatctttattcagcgattatgacgaaaataatgca 300 cacgttcatagcagaagattaatggaaaacatgagtttaaggtggcccaacaatcttgac 360 gatgctgatgaagtaagagataagctggcacagttgtcacctgaagagcagttttattat 420 aagcaaggtgaggagtatatcaagcagaacccaccatttctgcttaaccagggactttta 480 caacagtccgaagatagcaatccagacaccacccgtgaagaccctattatgaacgagcaa 540 acaaggcaatatattcaagaagagggggcttatgcatgggagtttagcccaaatcctgat 600 atgccaaaccatactgtcatagtggaaaataaaacagaggtttcttttctaaattataat 660 tatgatgcttctatatccacaaatctacccattccgtgtataaataaagtatattattgt 720 gaattcaagatatttgaaacggatggcccactaaacagtgatgaaaatgtatcgaaaggt 780 gtcatctcatttggtctttccacacagccttatccatatttcaggttaccgggaagacac 840 caccattcgatagcatacgattctaacggcgccagaagatttaatgactccttcaaacta 900 aatgagcaattaagaacgttatttccacagtgtgaaaagggagacattgttggcattggc 960 tataggtcacgtagtggaacagtatttttcaccaggaacggaaaaaaactaaatgaaaaa 1020 tctgttggtggtcatatccgcggctggaaattccaatacctatacccgatcattggctcc 1080 aacgtaccttgtcaaattcatgtgaatttcggcacttatggctttgtttatatagaagca 1140 aacgttaaaaaatggggatacgcaaagtcaaacggcattaaattacctcctccttcttac 1200 gaagactacggtaaagataccctattagaaagcggtggtgaagacaatgatttcgacgaa 1260 gatttttcagacggtgatagcgacaatattgcggctggtagtactacaaatctcaatgat 1320 gatataattataagaaacggtgaaatattaccgccaccacctggatttgaattcactatg 1380 tcccctcccactggaaagaagatcatcaatgaggaaattaatctagattccttacctatg 1440 ctaccaccaagttactcggacgatgaacatcattcgaaaaatgataaatcagcaataagc 1500 ggacgaattattggaacgagcagaaatttaattactgatgaagcatctttcgatagtgtt 1560 gataatgataacgaagatgaaaatgatcacgagagagatcccgaacaattttcagaattt 1620 gatgattacgaaagcaggatgcatggcatataa 1653 SEQIDNO:170 MSFKFLIESLLLGSISGQIRCGRSSVIPRGDVSYGGDDTDELNMDIMLFAFGTLIVVYIV 60 ICIVYFFTKQIATRLITAYYNEHGPGQRISLFSDYDENNAHVHSRRLMENMSLRWPNNLD 120 DADEVRDKLAQLSPEEQFYYKQGEEYIKQNPPFLLNQGLLQQSEDSNPDTTREDPIMNEQ 180 TRQYIQEEGAYAWEFSPNPDMPNHTVIVENKTEVSFLNYNYDASISTNLPIPCINKVYYC 240 EFKIFETDGPLNSDENVSKGVISFGLSTQPYPYFRLPGRHHHSIAYDSNGARRFNDSFKL 300 NEQLRTLFPQCEKGDIVGIGYRSRSGTVFFTRNGKKLNEKSVGGHIRGWKFQYLYPIIGS 360 NVPCQIHVNFGTYGFVYIEANVKKWGYAKSNGIKLPPPSYEDYGKDTLLESGGEDNDFDE 420 DFSDGDSDNIAAGSTTNLNDDIIIRNGEILPPPPGFEFTMSPPTGKKIINEEINLDSLPM 480 LPPSYSDDEHHSKNDKSAISGRIIGTSRNLITDEASFDSVDNDNEDENDHERDPEQFSEF 540 DDYESRMHGI 550 SEQIDNO:171 atgtatgtcacttttaatgaggctttggatagttcttttggtaatctagagagtccgaat 60 catgacttcaaagtaggtgaccctaacatggtaccaactccccctatggattcagattct 120 gcagcaattagtttggctttcttaataagtctttctattacgtttgcaatattaatgctc 180 atcttggtagtaatagcggcatatgtcaccttttgtggtgatgatgaatcagaatacgac 240 gaagagaacgccttaggtacacgaacttcaggaactctgcactctttgtttggtaaaaaa 300 catagtggcatcttgttggattcgagttttgcatcccctggcgggtttgatgatgagatc 360 gttcttcaggaaagagaacttgaagaattaccaaagatgtcagcgtacgaggttgagttg 420 tatataagagcgaaagagtttcaaatgatgagcccgccaatggtgaaggactttggcacg 480 tatttggacagtgacgaccagcagtttattaaggatcgtggcattcaaagctattttttg 540 ctaccaagcattaatgataatatagacgaatatggaaactttctacccagttttattgtc 600 caggataaactagatattcaattttcaaagttcaataagagctcatccactgtaatgaac 660 tatcccctacctcacaataggaaggacgcagtgtatttcgaagttaaaattttcagacat 720 attcaaaagtccaatagtatattcagtataggtttgactactgtaccatatccttatttc 780 agggtaccgggcatggccaaatactccattgcatacgaatccacaggtaaactgaggata 840 aataaccccttcactgccagcacattattaccaaaattggaagaaggtgacacggtagga 900 ttcggttacagatataaaacaggtacaatcttcattacacataatgggaaaaaattaatg 960 gatgtaacacaaaatattggcattgatcttttcattggaattggcgcgtttaatgccgca 1020 tatacaagaacatatacgagggatggtctattggaagacccggataatgttagcttccgt 1080 gaagctctctctgaaggcaaagatattgaagtcgccaaagatcttcaaagagttcacgat 1140 ccacatgatgaaagtgatgaaatgacgtcagatgaggttgaattacatgttaatttgggc 1200 caagttgggttcgtctttatagaagccaatgtgaaaaaatatgcgtttgggagtgtttat 1260 ggccaaattggaattcctcctgcgtataatggaaccgagatcaagaaggatactatttta 1320 cagaaaggagaagaattgccaccaagatatgctgacactgataatttctttggtagtatg 1380 aaggtaaaagaagggtcatcctctaggataacggcgcaaactagtaagcccctgtggtct 1440 gttgggacgtatgaaagaatctcttctaactttgacagagaaaataatgtttaccacgac 1500 agtcttgaaaccgacgataacaacaccgataacaatgttaataacaacgatgagaacgct 1560 ggttgcaatgaaaattcgccattattggaagatgatggcaataaaagaccggaaaattca 1620 aataccccccgtgaagtatcagatggagctatcaataagaaccctagaaataaatctact 1680 aaaaaacgtcaaagaaacagaggcaaatcttctaaaaagaagaacagatcgagaaaataa 1740 SEQIDNO:172 MYVTFNEALDSSFGNLESPNHDFKVGDPNMVPTPPMDSDSAAISLAFLISLSITFAILML 60 ILVVIAAYVTFCGDDESEYDEENALGTRTSGTLHSLFGKKHSGILLDSSFASPGGFDDEI 120 VLQERELEELPKMSAYEVELYIRAKEFQMMSPPMVKDFGTYLDSDDQQFIKDRGIQSYFL 180 LPSINDNIDEYGNFLPSFIVQDKLDIQFSKFNKSSSTVMNYPLPHNRKDAVYFEVKIFRH 240 IQKSNSIFSIGLTTVPYPYFRVPGMAKYSIAYESTGKLRINNPFTASTLLPKLEEGDTVG 300 FGYRYKTGTIFITHNGKKLMDVTQNIGIDLFIGIGAFNAAYTRTYTRDGLLEDPDNVSFR 360 EALSEGKDIEVAKDLQRVHDPHDESDEMTSDEVELHVNLGQVGFVFIEANVKKYAFGSVY 420 GQIGIPPAYNGTEIKKDTILQKGEELPPRYADTDNFFGSMKVKEGSSSRITAQTSKPLWS 480 VGTYERISSNFDRENNVYHDSLETDDNNTDNNVNNNDENAGCNENSPLLEDDGNKRPENS 540 NTPREVSDGAINKNPRNKSTKKRQRNRGKSSKKKNRSRK 579 SEQIDNO:173 atggtgaatactaggggctacactactcttccgaatgttgaagaaccagcaaataactca 60 caagatgagctaaactcgcaggactttgagcaagctataggaatgccatcagaacccccg 120 gtatatgtggaagagatggggatggaagaaccgcaggctccggaagcctttagtgagaaa 180 gtccagcgatttcgtatgtgttttgaaaataacgtggtgattccagtaaagaaaaatgta 240 gtggatccgctagcacaaatgatttccctggcctctgagaaattcgatttgttcttaagt 300 aaaataggtaatgttatggtaatgaggagaatattttacatcatgatgatgtctatcatt 360 gcagcgttgattattgcgagtgataggttaccgaatggaaaagctcgaggttcaaatgga 420 tcattctcggaccatgatctccttttacagtatgctcggaaatcgatagacctttcaaag 480 atagaaagagatttagagtatattagtagtatgccccacatgtcaggaacaagtggtgat 540 gccgctattagacattatattaaagagtcgttcgacaaaaatggtataaggctagctggg 600 gaagaggagttcatggcgtattcgaattacccaggaaatgtctcacttcgtgtatattca 660 aaggatgatacagaagggtttgatattcccttaaatgaggagaactttaacccaatgagc 720 cataatggtcaattgaacaacataccggtgatttatgctaataaagcatcgttggacgat 780 atggcttctatgcaagatcaagggcttttaaacggtgactttattttactagtgcattac 840 ggagattatgttttccaacaaatgttgactgctcaagaatatggtgcgaaagcaattatc 900 tttatttctgagccttatcaagacaacaaagacgtgatacaaatgaagtcagttgcgttg 960 ccgcagtatggtactggtgatgcacttacgcctgaatgggaaggatcaataagagatcct 1020 atcgatgctacggaagccaagtgcctacccaaaattccatccataccgatatctgccaat 1080 caaggagataaaatactagctatattatcagacactggcgtaaagttttctaataattta 1140 ttcagtgggtcgcttaacgattgtcgacttgacctactagtgcaaacagcaattagggaa 1200 cgccacccggttcacgatatagttggtaaaattgaaggatcggaacaagcgggcagggca 1260 attgttattgctgcaccgaggaactctgctagttatggcactatgtatccttcttttgga 1320 accgtcgttttgctgtctctgatccaattatatcaagaaatggtttacaaatttgactgg 1380 aagcctctaagaaatatatatttcatttcctttgggggctctgaatttaatgaagcggga 1440 gccacggagctgatggaaaagagaacagaggcattgaagagtgaaatatacaccattatc 1500 gacgtcggccaaatcggtatatgggatgatagtaacaatttagagatacaatgtcatccg 1560 ctactagtagatctttttcaaaaaaacatgacaagccgtaaatttaacgttaaagtggat 1620 aatgttcaccagttcggcgactggacgccgtatctagcgcaagggattccagttgcgatc 1680 atttcatctccaggagtcatgaatagagaacatccgatctacacagtagaagacaaattc 1740 gatttcatcaaagataaactaagagacaaaaagaagggagaggtactttctgagataatg 1800 ctatatcttgtcgaaaaatcactcgagctcattgacgatccattcatcccattcagcata 1860 tcgaactacgtagatttcctttcaactacgttaaaagacctccaaaaagaatgtcctgat 1920 acggtaaactttgacgaagtctttttgggcacaacattgtgggaaaacactaaactgcag 1980 ttcgaaaaatggaaaagcgaatggacagagcttatgtatggagccggtacatatatagaa 2040 cccactatcattgccattaatcgttggtcatggaactacctactttccctaataggcgtt 2100 acccaatgtttggaggaagggttaatggatagaaccttttacaagaacgttatcttcggg 2160 ccaaaactctgggtcgacaaaggtgacccacttcgttcatggacgttccctgaaatcagg 2220 gacactattgcaatcaaggactggagctctgtgcaggttcaagctaacacactcggcaca 2280 attttacaaaatacagcacgctattttcttgagaataaaaaccttcatggaataaacacg 2340 aacgaattttag 2352 SEQIDNO:174 MVNTRGYTTLPNVEEPANNSQDELNSQDFEQAIGMPSEPPVYVEEMGMEEPQAPEAFSEK 60 VQRFRMCFENNVVIPVKKNVVDPLAQMISLASEKFDLFLSKIGNVMVMRRIFYIMMMSII 120 AALIIASDRLPNGKARGSNGSFSDHDLLLQYARKSIDLSKIERDLEYISSMPHMSGTSGD 180 AAIRHYIKESFDKNGIRLAGEEEFMAYSNYPGNVSLRVYSKDDTEGFDIPLNEENFNPMS 240 HNGQLNNIPVIYANKASLDDMASMQDQGLLNGDFILLVHYGDYVFQQMLTAQEYGAKAII 300 FISEPYQDNKDVIQMKSVALPQYGTGDALTPEWEGSIRDPIDATEAKCLPKIPSIPISAN 360 QGDKILAILSDTGVKFSNNLFSGSLNDCRLDLLVQTAIRERHPVHDIVGKIEGSEQAGRA 420 IVIAAPRNSASYGTMYPSFGTVVLLSLIQLYQEMVYKFDWKPLRNIYFISFGGSEFNEAG 480 ATELMEKRTEALKSEIYTIIDVGQIGIWDDSNNLEIQCHPLLVDLFQKNMTSRKFNVKVD 540 NVHQFGDWTPYLAQGIPVAIISSPGVMNREHPIYTVEDKFDFIKDKLRDKKKGEVLSEIM 600 LYLVEKSLELIDDPFIPFSISNYVDFLSTTLKDLQKECPDTVNFDEVFLGTTLWENTKLQ 660 FEKWKSEWTELMYGAGTYIEPTIIAINRWSWNYLLSLIGVTQCLEEGLMDRTFYKNVIFG 720 PKLWVDKGDPLRSWTFPEIRDTIAIKDWSSVQVQANTLGTILQNTARYFLENKNLHGINT 780 NEF 783 SEQIDNO:175 atgaggagcagttatcaaccagtgtcaactacaaactttgaacatgaaaatgctatacct 60 actgcgtcgtcgtcccataatctgttgatgagccagcgttttgatgattctcctcctagt 120 tctaacgacaacagtatagaaactaatataacgcctccacctgaaccaccttcttatgaa 180 tttgatatagaggaccctcacgatgatcttcacaaaagaacacatctacagagggtttca 240 attgggtttcaggaaaaaattttggaacccttaatggaaaacatcattcatccactctta 300 caaatatcaaaattcgttccagacaaagctgactattacttaagtaaaatcggaaatccc 360 tttatacttcgaaggttcttttacatcattttcatgtcatttattgcatattatgtcttg 420 tcaagtggctacttattcaacgaaaaggcatcaggatctaaagggatgttttctcaacac 480 gatatactttttgaatatgccaaaaaatccgtggatttggcaaagtttgagagagatttg 540 gaatatattagtagcatgcctcatggatccggaacgaagggtgatgcagctatttatcga 600 tacattcaggaatcttttgacaacaatgggttgaaattggttaaagaaatgggatactca 660 gtttattctaattatccaggcaatgtatcaatttcatattatgataacaagaatgaaaag 720 catgatctagaactttctaaagaaaatttcaatccgttgagttctaacgggaaattatcc 780 aaagtgagcttgatttatggaggcaaaggtacaacatacgatttacaacatttaaaagat 840 tcgaaaacgatagaagatgggaaggactatgtgcttttactgcaatatgataaattagtg 900 agtcagcaagtactaattgctgagaaattcggagctaaagctgtaatcttcatatctgag 960 ccatatggtgagaatatagacgttgttcaatctaagcctgtaggattgccccaatattcg 1020 actggtgatgcatcaggattgaattgggatggttctcctgtagaagaaaaggatcataaa 1080 ttttggcgtcaaactcatattccaactatcccaatctccacgagacaaggaaaagagcta 1140 ctatcgcgtttatcttcaggaggagtaacggttgatgatggtaatagtgatcgtagtaac 1200 agtgggaaaatgggagacgtattgatcgatgtagatctgcaaactaatgttagggaaaag 1260 cattttattcctaatattgttggtaaaattgaagggagagaacaatcagacaaagctata 1320 ataattgctgcatcgagaaattccatcaattttggaactacttatcccaattttggtaca 1380 gctgcattattatctatagttcaattattccaagaggtgaaatataagtttggttggaaa 1440 cctttgagaaatatctatttcatctcattcggtggtaccgaatttaattatgctggatct 1500 tcggagctggttgagcaaaggctaacgccattaaaagacgaaatttattctttgattgat 1560 attagtcaactgggtataccctttgccgaaaaatatgagaacggtaaaactagaggagaa 1620 ttaagcattgagacacatcccttattgaagaagtttttcaatagaaacgcgcatggaaac 1680 tttgatatatctgtggataatgtacagcactatggtgactggactccatttctggcaaat 1740 ggaattcctgtatctgtaatatcttctgattctacgagaaaccgtgacaccccaactgaa 1800 acatctgaggataaatttgaacgtgttgagaagattctggaagacgaacagaaccaacaa 1860 tctgtcaaggatttgctagtatatcttttacatattagtatggaattgattgatgacccg 1920 ctacttcattttgacataataagctatgttgaagatatcgatgaaagattgcaaaggtta 1980 gagcaagcataccctgaaaaactaaacttcacatcaataatcaaaggtttgttattttgg 2040 aagaaaatcggtagcgaatgggcgtcatggactcaaggttgggagaacatagtatggtcg 2100 catggggatggtatagagccctccttactttcaattaataggtggacatggaataaaaaa 2160 ttgactaatattggtagaagaacatgctctccggcgggtctacctaatagatcattttat 2220 aagaacgttttgttcggaccaacattgatacaggaggataaatctaaaaatggtggaaat 2280 gtagatttctggacatttccaggagtgatggatgcgatttacgatgatgactggaagagg 2340 gctcaagaacaaattgaccttattggcaaagtactccatcagtctgctgcattgtttgtc 2400 gaagagactaatgacatcgggtataaataa 2430 SEQIDNO:176 MRSSYQPVSTTNFEHENAIPTASSSHNLLMSQRFDDSPPSSNDNSIETNITPPPEPPSYE 60 FDIEDPHDDLHKRTHLQRVSIGFQEKILEPLMENIIHPLLQISKFVPDKADYYLSKIGNP 120 FILRRFFYIIFMSFIAYYVLSSGYLFNEKASGSKGMFSQHDILFEYAKKSVDLAKFERDL 180 EYISSMPHGSGTKGDAAIYRYIQESFDNNGLKLVKEMGYSVYSNYPGNVSISYYDNKNEK 240 HDLELSKENFNPLSSNGKLSKVSLIYGGKGTTYDLQHLKDSKTIEDGKDYVLLLQYDKLV 300 SQQVLIAEKFGAKAVIFISEPYGENIDVVQSKPVGLPQYSTGDASGLNWDGSPVEEKDHK 360 FWRQTHIPTIPISTRQGKELLSRLSSGGVTVDDGNSDRSNSGKMGDVLIDVDLQTNVREK 420 HFIPNIVGKIEGREQSDKAIIIAASRNSINFGTTYPNFGTAALLSIVQLFQEVKYKFGWK 480 PLRNIYFISFGGTEFNYAGSSELVEQRLTPLKDEIYSLIDISQLGIPFAEKYENGKTRGE 540 LSIETHPLLKKFFNRNAHGNFDISVDNVQHYGDWTPFLANGIPVSVISSDSTRNRDTPTE 600 TSEDKFERVEKILEDEQNQQSVKDLLVYLLHISMELIDDPLLHFDIISYVEDIDERLQRL 660 EQAYPEKLNFTSIIKGLLFWKKIGSEWASWTQGWENIVWSHGDGIEPSLLSINRWTWNKK 720 LTNIGRRTCSPAGLPNRSFYKNVLFGPTLIQEDKSKNGGNVDFWTFPGVMDAIYDDDWKR 780 AQEQIDLIGKVLHQSAALFVEETNDIGYK 809 SEQIDNO:177 atgacctctttatatgcacctggggcggaggatattcggcaaaggttacgtccttttggg 60 tttttctttgagaaatcactaaaggatttgattaagggtattaggtctcacaacgaaaca 120 ccagaaaaactggatcaattctttaaacaagtattaagtgaatgccgggaagaagtgaac 180 tctccagatctaaattctaagaccaatgccgttcttaaattgacctatttagagatgtac 240 ggttttgacatggcttggtgcaactttcatatcttagaggttatgagcagtaataaactt 300 caacaaaaacgtgtggggtatttggctgcatcacaatctttttacaaagattctgacatt 360 ttgatgcttgcaactaacttgttgaaaaaagacttaaagtatgacggaaacaatgatgtt 420 gttaaagttggcattgctttaagtggtctttccactataattacaccctcattagcaaga 480 gatatagctgatgatttgttcactatgctaaacagcacaagaccgtacataagaaagaag 540 gccattaccgcactatttaaagtttttctgcaatatccagaggctttgagagataatttt 600 gataagtttgtttcaaagctagacgatgatgatatatctgtggtttctgccgctgtcagt 660 gttatttgcgagctatcaaaaaaaaacccccaaccattcatccagctttcacctttatta 720 tacgagatattagttaccattgacaataactggataatcattagattattgaagttattc 780 accaacttatcacaagtggaaccgaaattgagagccaagttattgccgaaaattttagaa 840 ctgatggagagtactgttgcaacttctgtgatctatgaatctgtcaactgtattgtcaag 900 gggaatatgctagaagaagatgattttgaaacagcaatggcatgcctggaaagattgcac 960 acattttgtgattctcaggatccaaatttgagatatattagctgcatattgttttacaag 1020 atcggcaaaatcaatactgattttatttctcggttcgaccaactgattatacgcttactc 1080 tccgatgtcgacgtttctataagatcaaaagcaattgaattggttgaaggtattgttgat 1140 gaggataacttaaaggcaattgtccaaacattgatgaagcaatttgtagatgaagatgtg 1200 gttatcctacaaactggaagcatcgtatacgaaaaatcaaagagaattcccataataatt 1260 ccagaaaattacaagataaaaatggtgaacgtcattatatcgatttgttcagctgacaac 1320 tattccagtgttaacgactttgaatggtacaatgcagtaataatggacttggcgatgctc 1380 tgtcaagacatatctgataaaagccttggatcaaaaattggtgaacagtttaggaatttg 1440 atgataaaagttccttcaatgagagaagtaaccattgctaatattataaagcttatttca 1500 aatgacaatattaacaaacagttgcctaccgtattgagagaatgcatttggtgtctcgga 1560 gaattttctaccctagttgaaaatggtaacgacttaataaaaatcatgactgagaatatc 1620 agttattattctcatagtgtacaagaagttttaattttagcacttgttaaagtatttagt 1680 aattggtgtaataactttcaggaggataaacgctttgaaattaaaatggtgttaaaagag 1740 ctaattgaattttttgaaaatttatcttattcgagtacattcgaagtccaggaaagaagc 1800 gtagaagttttagaatttttaagactaagtttggaggctttagaggaggatacggaaggt 1860 ctaccaatgctactgagcgaagtcctgcctagtttttttaacgcctatgaactcgcacca 1920 attgcgcgtgggactcaattgaagttagcagtagatgagaatcttgatctagaaactcca 1980 tttttgacaaaggaggcagctgatgaactcttagatgaacaaaaaagtgacgccatcagt 2040 gatttaatgtctgatatctcaatggacgagcaagttgaactaaaattcgttgatgattct 2100 gatacttcgtatgaagaaaaggaaaaattggatgattttgaaaatccatttgagattgag 2160 agagaaaaggaacggatgtcaaatccttattatctaggtgaagaagacgaagaaagaact 2220 aagaactctaaagatttgttggacttgaatgaggaggaaagtagtgataaaaagccagaa 2280 actattagattaaatagaaccgataattcgttgaattctctaagtttatctacaactgaa 2340 atcagcagaaagaagaagaagggaaagaagaaaaatagggttcaagtcttatccgatgaa 2400 cctgttatcgaagccgctcccaaaaggaaagatgcattccagaaaccccatgataatcat 2460 tcaactcaaaatcctttgaaaaaggacaagattaatctgagaatgcactctcaacttgaa 2520 aattttgatttttccaattttgggcaatcgagtaacgcaggaagaggatcgcaggaagag 2580 ggcaaccttagaaaggaagacgagttagaattaagtcgtttagaggccaatcttattgta 2640 aaagatgaaaaggataatttaagtgatactgaagaagttatagttataaaaaagaagaag 2700 aaagggaaaaagtcaaagtcaaaaaacaaactaaaaacgaaagcaaaaaattctccagaa 2760 ccaaatgaatttcttcgagaccaaagcactgacatttaa 2799 SEQIDNO:178 MTSLYAPGAEDIRQRLRPFGFFFEKSLKDLIKGIRSHNETPEKLDQFFKQVLSECREEVN 60 SPDLNSKTNAVLKLTYLEMYGFDMAWCNFHILEVMSSNKLQQKRVGYLAASQSFYKDSDI 120 LMLATNLLKKDLKYDGNNDVVKVGIALSGLSTIITPSLARDIADDLFTMLNSTRPYIRKK 180 AITALFKVFLQYPEALRDNFDKFVSKLDDDDISVVSAAVSVICELSKKNPQPFIQLSPLL 240 YEILVTIDNNWIIIRLLKLFTNLSQVEPKLRAKLLPKILELMESTVATSVIYESVNCIVK 300 GNMLEEDDFETAMACLERLHTFCDSQDPNLRYISCILFYKIGKINTDFISRFDQLIIRLL 360 SDVDVSIRSKAIELVEGIVDEDNLKAIVQTLMKQFVDEDVVILQTGSIVYEKSKRIPIII 420 PENYKIKMVNVIISICSADNYSSVNDFEWYNAVIMDLAMLCQDISDKSLGSKIGEQFRNL 480 MIKVPSMREVTIANIIKLISNDNINKQLPTVLRECIWCLGEFSTLVENGNDLIKIMTENI 540 SYYSHSVQEVLILALVKVFSNWCNNFQEDKRFEIKMVLKELIEFFENLSYSSTFEVQERS 600 VEVLEFLRLSLEALEEDTEGLPMLLSEVLPSFFNAYELAPIARGTQLKLAVDENLDLETP 660 FLTKEAADELLDEQKSDAISDLMSDISMDEQVELKFVDDSDTSYEEKEKLDDFENPFEIE 720 REKERMSNPYYLGEEDEERTKNSKDLLDLNEEESSDKKPETIRLNRTDNSLNSLSLSTTE 780 ISRKKKKGKKKNRVQVLSDEPVIEAAPKRKDAFQKPHDNHSTQNPLKKDKINLRMHSQLE 840 NFDFSNFGQSSNAGRGSQEEGNLRKEDELELSRLEANLIVKDEKDNLSDTEEVIVIKKKK 900 KGKKSKSKNKLKTKAKNSPEPNEFLRDQSTDI 932 SEQIDNO:179 atggtagattcaattcaccgtattgcatcggcgttggatacggccaaagtaataacgagg 60 gaagctgccgcggtagccacctctaagctgggtgaatcctcctatacttattattctcaa 120 aacatcaatcctcaacagttagtcaccttgttaaattctaggaactctagagaagttaga 180 gatgcaatgaagagaataatatctataatggcttccgatgatgactctattgacgttcaa 240 ttatactttgctgatgttgtaaagaatatcaccactaatgacaccaaagtgaaaagactt 300 attcacctgtatttacttagatttgcagaaaatgacccaaacctgaccctgttatctatt 360 aattctcttcaaaaatcattgtctgattcgaattccgaactgagatgctttgctttgagt 420 gccctttctgacatgaaaatgtcatcattagcacctataattttgcatactgtcaagaaa 480 ttggttacagatccatctgcaatggttcgtggtgaagtcgccttggccattatcaaatta 540 tatagggctggaaagaatgactatcatgaagaattgttggatattctgaaagaattaatg 600 gcagatacagatcctaaggtgatatcctgtgctgtcctagcttacaaagaatgttatgcg 660 gatcacttggagctattgcatggacattttcgcagatattgtagaataattaagcaacta 720 gattcgtggtcacaatcatatttaattgagctgctaatcaagtactgtaagcagtattta 780 ccaaaaccaactgtggtcgataaatcatcagaaggttccccaaggagttgtcctttacca 840 gataaatacaacgagattgaatacccatcttacgaggtggtaaatgaccctgatttagat 900 ttatttctacagagtttgaattgcttaatttatagttccaaccctacagtgattttatcg 960 tgttgcaatgcgctatatcagttagcttcaccattgcagatgaaaaatactaaatttatt 1020 gaagcattggttagaacggtaaccatgacagaaaaccaaggtaacaaagaaatgctttta 1080 caagcaattcacttcttatcgatcttagaccagacactatttttaccctacaccaagaaa 1140 ttttacgttttccccaaagatcctattgtggcatcaatttggaagatccaaattttgtcc 1200 acgttaataaatgaatcaaacgttaaagaaatattcaaagaattgaaatattatgttgcc 1260 agtgctcatttcccagaaaatgttgttattatggcggttaagtcattatctcgatgtggc 1320 caattgtcaacgagttgggaatcacatgtaatgaagtggttaattgatcatatggaatcc 1380 cacaacctctctgcttctgtcctagatgcatacgtgaatgttatcaggatgctggtgcaa 1440 aaaaatcctacaaaacatcttcgcataatcttcaagcttgcagatttattaacagttcaa 1500 acgagtttggctgataatgctcgtgcaggtattgtttggttatttggtgaaattgcctcg 1560 attgaatttaagatatgtccggacgttttgaggaggctaatccagaatttttcaaatgag 1620 ggtcctgagacaagatgtcagatcttagtgttatcagcaaaactgttgtcatatgacatt 1680 gataattttaagcaagcgcaagttactggaagcgaagaaaataaccaaaatcccccatac 1740 tatgattttagtggttcaagaatctctcaaatgtacaatgcggtcctttacttggcaaaa 1800 tatgatgacgaatttgatattagggatagagccaggatgatttcatccttgtttgattca 1860 gggaaatatgaaattgtgtcactactattacaagcacctaaacctacggcaagaagtgac 1920 gattttatcgtttctgcaagattggaaacacataccccagaaataaaagaattttttaga 1980 atgcttccttggaatactgaaattactgaggttggcgagacaggtaacgatattagagaa 2040 ggcgcagaattgaaagactataacaaatacaaaaaaagtttttcatcgcagtcttttatt 2100 accaacaactcagcaagatctttcacatctagctccaacgcaaaattgactgggatcaat 2160 gacggcgatagcaatagcatctcaggtaaaggtaacgtaaacaccttcacatctcaaaac 2220 gggaagaaatatcgtttgcaaagcctggacgagtttttttccgacattccagaaaggaag 2280 agtaaaccaaggaaaattataaaggtggtggaagaaagcagtgacgaggatgaagacgaa 2340 tcggaagagagcagtgacgatgatgagtatagtgactcttctttgggaacgtcttcttcg 2400 ggaacgtcttcttcgcatctggagctttag 2430 SEQIDNO:180 MVDSIHRIASALDTAKVITREAAAVATSKLGESSYTYYSQNINPQQLVTLLNSRNSREVR 60 DAMKRIISIMASDDDSIDVQLYFADVVKNITTNDTKVKRLIHLYLLRFAENDPNLTLLSI 120 NSLQKSLSDSNSELRCFALSALSDMKMSSLAPIILHTVKKLVTDPSAMVRGEVALAIIKL 180 YRAGKNDYHEELLDILKELMADTDPKVISCAVLAYKECYADHLELLHGHFRRYCRIIKQL 240 DSWSQSYLIELLIKYCKQYLPKPTVVDKSSEGSPRSCPLPDKYNEIEYPSYEVVNDPDLD 300 LFLQSLNCLIYSSNPTVILSCCNALYQLASPLQMKNTKFIEALVRTVTMTENQGNKEMLL 360 QAIHFLSILDQTLFLPYTKKFYVFPKDPIVASIWKIQILSTLINESNVKEIFKELKYYVA 420 SAHFPENVVIMAVKSLSRCGQLSTSWESHVMKWLIDHMESHNLSASVLDAYVNVIRMLVQ 480 KNPTKHLRIIFKLADLLTVQTSLADNARAGIVWLFGEIASIEFKICPDVLRRLIQNFSNE 540 GPETRCQILVLSAKLLSYDIDNFKQAQVTGSEENNQNPPYYDFSGSRISQMYNAVLYLAK 600 YDDEFDIRDRARMISSLFDSGKYEIVSLLLQAPKPTARSDDFIVSARLETHTPEIKEFFR 660 MLPWNTEITEVGETGNDIREGAELKDYNKYKKSFSSQSFITNNSARSFTSSSNAKLTGIN 720 DGDSNSISGKGNVNTFTSQNGKKYRLQSLDEFFSDIPERKSKPRKIIKVVEESSDEDEDE 780 SEESSDDDEYSDSSLGTSSSGTSSSHLEL 809 SEQIDNO:181 atggtcgcacaaactttcaacctggatacctacttatcccaaagacaacaacaagttgaa 60 gaggccctaagtgctgctcttgtgccagcttatcctgagagaatatacgaagctatgaga 120 tactccctcctggcaggtggcaaaagattaagacctatcttatgtttagctgcttgcgaa 180 ttggcaggtggttctgttgaacaagccatgccaactgcgtgtgcacttgaaatgatccat 240 acaatgtcactaattcatgatgacctgccagccatggataacgatgatttcagaagagga 300 aagccaactaatcacaaggtgttcggggaagatatagccatcttagcgggtgatgcgctt 360 ttagcttacgcttttgaacatattgcttctcaaacaagaggagtaccacctcaattggtg 420 ctacaagttattgctagaatcggacacgccgttgctgcaacaggcctcgttggaggccaa 480 gtcgtagaccttgaatctgaaggtaaagctatttccttagaaacattggagtatattcac 540 tcacataagactggagccttgctggaagcatcagttgtctcaggcggtattctcgcaggg 600 gcagatgaagagcttttggccagattgtctcattacgctagagatataggcttggctttt 660 caaatcgtcgatgatatcctggatgttactgctacatctgaacagttggggaaaaccgct 720 ggtaaagaccaggcagccgcaaaggcaacttatccaagtctattgggtttagaagcctct 780 agacagaaagcggaagagttgattcaatctgctaaggaagccttaagaccttacggttca 840 caagcagagccactcctagcgctggcagacttcatcacacgtcgtcagcattaa 894 SEQIDNO:182 MVAQTFNLDTYLSQRQQQVEEALSAALVPAYPERIYEAMRYSLLAGGKRLRPILCLAACE 60 LAGGSVEQAMPTACALEMIHTMSLIHDDLPAMDNDDFRRGKPTNHKVFGEDIAILAGDAL 120 LAYAFEHIASQTRGVPPQLVLQVIARIGHAVAATGLVGGQVVDLESEGKAISLETLEYIH 180 SHKTGALLEASVVSGGILAGADEELLARLSHYARDIGLAFQIVDDILDVTATSEQLGKTA 240 GKDQAAAKATYPSLLGLEASRQKAEELIQSAKEALRPYGSQAEPLLALADFITRRQH 297 SEQIDNO:183 gcacagcacacatcagaatccgcagctgtcgcaaagggcagcagtttgacccctatagtg 60 agaactgacgctgagtcaaggagaacaagatggccaaccgatgacgatgacgccgaacct 120 ttagtggatgagatcagggcaatgcttacttccatgtctgatggtgacatttccgtgagc 180 gcatacgatacagcctgggtcggattggttccaagattagacggcggtgaaggtcctcaa 240 tttccagcagctgtgagatggataagaaataaccagttgcctgacggaagttggggcgat 300 gccgcattattctctgcctatgacaggcttatcaatacccttgcctgcgttgtaactttg 360 acaaggtggtccctagaaccagagatgagaggtagaggactatcttttttgggtaggaac 420 atgtggaaattagcaactgaagatgaagagtcaatgcctattggcttcgaattagcattt 480 ccatctttgatagagcttgctaagagcctaggtgtccatgacttcccttatgatcaccag 540 gccctacaaggaatctactcttcaagagagatcaaaatgaagaggattccaaaagaagtg 600 atgcataccgttccaacatcaatattgcacagtttggagggtatgcctggcctagattgg 660 gctaaactacttaaactacagagcagcgacggaagttttttgttctcaccagctgccact 720 gcatatgctttaatgaataccggagatgacaggtgttttagctacatcgatagaacagta 780 aagaaattcaacggcggcgtccctaatgtttatccagtggatctatttgaacatatttgg 840 gccgttgatagacttgaaagattaggaatctccaggtacttccaaaaggagatcgaacaa 900 tgcatggattatgtaaacaggcattggactgaggacggtatttgttgggcaaggaactct 960 gatgtcaaagaggtggacgacacagctatggcctttagacttcttaggttgcacggctac 1020 agcgtcagtcctgatgtgtttaaaaacttcgaaaaggacggtgaatttttcgcatttgtc 1080 ggacagtctaatcaagctgttaccggtatgtacaacttaaacagagcaagccagatatcc 1140 ttcccaggcgaggatgtgcttcatagagctggtgccttctcatatgagttcttgaggaga 1200 aaagaagcagagggagctttgagggacaagtggatcatttctaaagatctacctggtgaa 1260 gttgtgtatactttggattttccatggtacggcaacttacctagagtcgaggccagagac 1320 tacctagagcaatacggaggtggtgatgacgtttggattggcaagacattgtataggatg 1380 ccacttgtaaacaatgatgtatatttggaattggcaagaatggatttcaaccactgccag 1440 gctttgcatcagttagagtggcaaggactaaaaagatggtatactgaaaataggttgatg 1500 gactttggtgtcgcccaagaagatgcccttagagcttattttcttgcagccgcatctgtt 1560 tacgagccttgtagagctgccgagaggcttgcatgggctagagccgcaatactagctaac 1620 gccgtgagcacccacttaagaaatagcccatcattcagagaaaggttagagcattctctt 1680 aggtgtagacctagtgaagagacagatggctcctggtttaactcctcaagtggctctgat 1740 gcagttttagtaaaggctgtcttaagacttactgattcattagccagggaagcacagcca 1800 atccatggaggtgacccagaagatattatacacaagttgttaagatctgcttgggccgag 1860 tgggttagggaaaaggcagacgctgccgatagcgtgtgcaatggtagttctgcagtagaa 1920 caagagggatcaagaatggtccatgataaacagacctgtctattattggctagaatgatc 1980 gaaatttctgccggtagggcagctggtgaagcagccagtgaggacggcgatagaagaata 2040 attcaattaacaggctccatctgcgacagtcttaagcaaaaaatgctagtttcacaggac 2100 cctgaaaaaaatgaagagatgatgtctcacgtggatgacgaattgaagttgaggattaga 2160 gagttcgttcaatatttgcttagactaggtgaaaaaaagactggatctagcgaaaccagg 2220 caaacatttttaagtatagtgaaatcatgttactatgctgctcattgcccacctcatgtc 2280 gttgatagacacattagtagagtgattttcgagccagtaagtgccgcaaagtaaccgcgg 2340 SEQIDNO:184 AQHTSESAAVAKGSSLTPIVRTDAESRRTRWPTDDDDAEPLVDEIRAMLTSMSDGDISVS 60 AYDTAWVGLVPRLDGGEGPQFPAAVRWIRNNQLPDGSWGDAALFSAYDRLINTLACVVTL 120 TRWSLEPEMRGRGLSFLGRNMWKLATEDEESMPIGFELAFPSLIELAKSLGVHDFPYDHQ 180 ALQGIYSSREIKMKRIPKEVMHTVPTSILHSLEGMPGLDWAKLLKLQSSDGSFLFSPAAT 240 AYALMNTGDDRCFSYIDRTVKKFNGGVPNVYPVDLFEHIWAVDRLERLGISRYFQKEIEQ 300 CMDYVNRHWTEDGICWARNSDVKEVDDTAMAFRLLRLHGYSVSPDVFKNFEKDGEFFAFV 360 GQSNQAVTGMYNLNRASQISFPGEDVLHRAGAFSYEFLRRKEAEGALRDKWIISKDLPGE 420 VVYTLDFPWYGNLPRVEARDYLEQYGGGDDVWIGKTLYRMPLVNNDVYLELARMDFNHCQ 480 ALHQLEWQGLKRWYTENRLMDFGVAQEDALRAYFLAAASVYEPCRAAERLAWARAAILAN 540 AVSTHLRNSPSFRERLEHSLRCRPSEETDGSWFNSSSGSDAVLVKAVLRLTDSLAREAQP 600 IHGGDPEDIIHKLLRSAWAEWVREKADAADSVCNGSSAVEQEGSRMVHDKQTCLLLARMI 660 EISAGRAAGEAASEDGDRRIIQLTGSICDSLKQKMLVSQDPEKNEEMMSHVDDELKLRIR 720 EFVQYLLRLGEKKTGSSETRQTFLSIVKSCYYAAHCPPHVVDRHISRVIFEPVSAAK 777 SEQIDNO:185 atgtctattaatttgagatcttccggttgtagctccccaataagcgcaactttggaaagg 60 ggtctagactctgaagttcaaacaagagcaaacaatgtatcttttgagcagaccaaagag 120 aagatcaggaaaatgcttgagaaggtcgagttgagcgtgagtgcctatgacactagttgg 180 gtagctatggtcccatcaccatccagtcaaaacgcacctcttttcccacagtgcgtcaaa 240 tggctacttgataatcaacatgaggacggctcttggggattggataaccacgaccatcag 300 agcttaaagaaagatgtgttgtcatccacattagcctctatcctagctcttaagaaatgg 360 ggaataggcgaaagacagatcaataagggtctacagttcattgaattaaactctgcacta 420 gttaccgatgaaactatacaaaaacctacaggtttcgacatcatttttccaggaatgatt 480 aagtacgccagggaccttaatttgaccatacctcttggctcagaagtagtcgacgatatg 540 atcaggaaaagagatctagacttaaagtgtgatagcgagaaattcagcaaaggtagagag 600 gcttatcttgcctatgttcttgaaggaactaggaacttgaaggactgggacttaattgtg 660 aaatatcagagaaagaacggtagtctatttgatagtccagctacaaccgccgcagctttc 720 actcaatttggcaatgacggttgcttgaggtacttatgttcacttttacagaaattcgag 780 gccgcagtgcctagtgtatatccatttgatcaatacgctagattaagcataatcgtcact 840 ttagaatcattgggaattgacagagatttcaagactgagataaaaagcatattggatgag 900 acctataggtactggcttagaggtgacgaagaaatttgcctagatttggccacatgtgca 960 cttgcttttaggttgcttttagcccacggctatgacgtgtcatacgatcctctaaagcca 1020 tttgcagaggaatctggtttcagcgatacccttgagggatatgttaaaaacaccttttcc 1080 gtattagagcttttcaaggctgcccaaagttaccctcatgagagtgctttgaaaaagcag 1140 tgttgctggacaaaacaatatctagaaatggaactaagttcatgggttaaaacaagcgtt 1200 agggacaagtacttgaaaaaggaagtggaggatgctttggcatttccatcatatgcctct 1260 ttagaaagaagtgaccacagaaggaaaattcttaatggctcagcagttgaaaacacaaga 1320 gtaaccaagacctcttacaggttgcataatatatgtacatcagatatcttaaaacttgct 1380 gtcgacgatttcaacttttgccaatctattcatagagaggaaatggaaagattggataga 1440 tggatagtggagaatagactacaggaattaaagttcgccagacaaaaattggcttactgt 1500 tactttagtggcgctgccacactattctctccagaattgtctgacgcaaggatctcatgg 1560 gctaagggaggtgttctaaccacagtagtcgatgacttttttgatgttggcggtagtaaa 1620 gaagagcttgagaacttaattcacttggtggaaaagtgggatcttaatggagttcctgaa 1680 tactcttcagagcatgtagaaataattttctctgtcctaagagacactatcttagaaacc 1740 ggtgataaagcctttacatatcagggcagaaacgttactcaccatattgtgaaaatatgg 1800 ttggacttacttaagagcatgctaagggaggctgaatggtccagtgacaaatcaacccca 1860 tctttggaagattacatggagaatgcctatatcagcttcgcattaggtcctattgtattg 1920 ccagctacataccttataggacctccactacctgaaaagactgtcgactcccaccaatat 1980 aatcaattatacaaattggttagtaccatgggtagactattaaacgatatccagggcttt 2040 aagagggaatcagccgagggaaaacttaatgcagtgtctctacatatgaagcatgaaaga 2100 gacaacagaagcaaagaggttattatagaatccatgaaaggattggctgaaaggaaaaga 2160 gaggaattacacaaacttgtactagaagagaaaggtagtgtcgttccaagagaatgcaag 2220 gaagccttcttaaaaatgtcaaaagtgttgaaccttttttataggaaggatgatggcttc 2280 acatctaacgacttgatgagccttgtgaaatccgtcatctacgagcctgtttcacttcaa 2340 aaggagagtctaacttga 2358 SEQIDNO:186 MSINLRSSGCSSPISATLERGLDSEVQTRANNVSFEQTKEKIRKMLEKVELSVSAYDTSW 60 VAMVPSPSSQNAPLFPQCVKWLLDNQHEDGSWGLDNHDHQSLKKDVLSSTLASILALKKW 120 GIGERQINKGLQFIELNSALVTDETIQKPTGFDIIFPGMIKYARDLNLTIPLGSEVVDDM 180 IRKRDLDLKCDSEKFSKGREAYLAYVLEGTRNLKDWDLIVKYQRKNGSLFDSPATTAAAF 240 TQFGNDGCLRYLCSLLQKFEAAVPSVYPFDQYARLSIIVTLESLGIDRDFKTEIKSILDE 300 TYRYWLRGDEEICLDLATCALAFRLLLAHGYDVSYDPLKPFAEESGFSDTLEGYVKNTFS 360 VLELFKAAQSYPHESALKKQCCWTKQYLEMELSSWVKTSVRDKYLKKEVEDALAFPSYAS 420 LERSDHRRKILNGSAVENTRVTKTSYRLHNICTSDILKLAVDDFNFCQSIHREEMERLDR 480 WIVENRLQELKFARQKLAYCYFSGAATLFSPELSDARISWAKGGVLTTVVDDFFDVGGSK 540 EELENLIHLVEKWDLNGVPEYSSEHVEIIFSVLRDTILETGDKAFTYQGRNVTHHIVKIW 600 LDLLKSMLREAEWSSDKSTPSLEDYMENAYISFALGPIVLPATYLIGPPLPEKTVDSHQY 660 NQLYKLVSTMGRLLNDIQGFKRESAEGKLNAVSLHMKHERDNRSKEVIIESMKGLAERKR 720 EELHKLVLEEKGSVVPRECKEAFLKMSKVLNLFYRKDDGFTSNDLMSLVKSVIYEPVSLQ 780 KESLT 785 SEQIDNO:187 atggatgctgtgacgggtttgttaactgtcccagcaaccgctataactattggtggaact 60 gctgtagcattggcggtagcgctaatcttttggtacctgaaatcctacacatcagctaga 120 agatcccaatcaaatcatcttccaagagtgcctgaagtcccaggtgttccattgttagga 180 aatctgttacaattgaaggagaaaaagccatacatgacttttacgagatgggcagcgaca 240 tatggacctatctatagtatcaaaactggggctacaagtatggttgtggtatcatctaat 300 gagatagccaaggaggcattggtgaccagattccaatccatatctacaaggaacttatct 360 aaagccctgaaagtacttacagcagataagacaatggtcgcaatgtcagattatgatgat 420 tatcataaaacagttaagagacacatactgaccgccgtcttgggtcctaatgcacagaaa 480 aagcatagaattcacagagatatcatgatggataacatatctactcaacttcatgaattc 540 gtgaaaaacaacccagaacaggaagaggtagaccttagaaaaatctttcaatctgagtta 600 ttcggcttagctatgagacaagccttaggaaaggatgttgaaagtttgtacgttgaagac 660 ctgaaaatcactatgaatagagacgaaatctttcaagtccttgttgttgatccaatgatg 720 ggagcaatcgatgttgattggagagacttctttccatacctaaagtgggtcccaaacaaa 780 aagttcgaaaatactattcaacaaatgtacatcagaagagaagctgttatgaaatcttta 840 atcaaagagcacaaaaagagaatagcgtcaggcgaaaagctaaatagttatatcgattac 900 cttttatctgaagctcaaactttaaccgatcagcaactattgatgtccttgtgggaacca 960 atcattgaatcttcagatacaacaatggtcacaacagaatgggcaatgtacgaattagct 1020 aaaaaccctaaattgcaagataggttgtacagagacattaagtccgtctgtggatctgaa 1080 aagataaccgaagagcatctatcacagctgccttacattacagctattttccacgaaaca 1140 ctgagaagacactcaccagttcctatcattcctctaagacatgtacatgaagataccgtt 1200 ctaggcggctaccatgttcctgctggcacagaacttgccgttaacatctacggttgcaac 1260 atggacaaaaacgtttgggaaaatccagaggaatggaacccagaaagattcatgaaagag 1320 aatgagacaattgattttcaaaagacgatggccttcggtggtggtaagagagtttgtgct 1380 ggttccttgcaagcccttttaactgcatctattgggattgggagaatggttcaagagttc 1440 gaatggaaactgaaggatatgactcaagaggaagtgaacacgataggcctaactacacaa 1500 atgttaagaccattgagagctattatcaaacctaggatctaa 1542 SEQIDNO:188 MDAVTGLLTVPATAITIGGTAVALAVALIFWYLKSYTSARRSQSNHLPRVPEVPGVPLLG 60 NLLQLKEKKPYMTFTRWAATYGPIYSIKTGATSMVVVSSNEIAKEALVTRFQSISTRNLS 120 KALKVLTADKTMVAMSDYDDYHKTVKRHILTAVLGPNAQKKHRIHRDIMMDNISTQLHEF 180 VKNNPEQEEVDLRKIFQSELFGLAMRQALGKDVESLYVEDLKITMNRDEIFQVLVVDPMM 240 GAIDVDWRDFFPYLKWVPNKKFENTIQQMYIRREAVMKSLIKEHKKRIASGEKLNSYIDY 300 LLSEAQTLTDQQLLMSLWEPIIESSDTTMVTTEWAMYELAKNPKLQDRLYRDIKSVCGSE 360 KITEEHLSQLPYITAIFHETLRRHSPVPIIPLRHVHEDTVLGGYHVPAGTELAVNIYGCN 420 MDKNVWENPEEWNPERFMKENETIDFQKTMAFGGGKRVCAGSLQALLTASIGIGRMVQEF 480 EWKLKDMTQEEVNTIGLTTQMLRPLRAIIKPRI 513 SEQIDNO:189 atgtcttcctcttcctcttccagtacctctatgattgatttgatggctgctattattaaa 60 ggtgaaccagttatcgtctccgacccagcaaatgcctctgcttatgaatcagttgctgca 120 gaattgtcttcaatgttgatcgaaaacagacaattcgccatgatcgtaactacatcaatc 180 gctgttttgatcggttgtattgtcatgttggtatggagaagatccggtagtggtaattct 240 aaaagagtcgaacctttgaaaccattagtaattaagccaagagaagaagaaatagatgac 300 ggtagaaagaaagttacaatatttttcggtacccaaactggtacagctgaaggttttgca 360 aaagccttaggtgaagaagctaaggcaagatacgaaaagactagattcaagatagtcgat 420 ttggatgactatgccgctgatgacgatgaatacgaagaaaagttgaagaaagaagatgtt 480 gcatttttctttttggcaacctatggtgacggtgaaccaactgacaatgcagccagattc 540 tacaaatggtttacagagggtaatgatcgtggtgaatggttgaaaaacttaaagtacggt 600 gttttcggtttgggtaacagacaatacgaacatttcaacaaagttgcaaaggttgtcgac 660 gatattttggtcgaacaaggtgctcaaagattagtccaagtaggtttgggtgacgatgac 720 caatgtatagaagatgactttactgcctggagagaagctttgtggcctgaattagacaca 780 atcttgagagaagaaggtgacaccgccgttgctaccccatatactgctgcagtattagaa 840 tacagagtttccatccatgatagtgaagacgcaaagtttaatgatatcactttggccaat 900 ggtaacggttatacagttttcgatgcacaacacccttacaaagctaacgttgcagtcaag 960 agagaattacatacaccagaatccgacagaagttgtatacacttggaatttgatatcgct 1020 ggttccggtttaaccatgaagttgggtgaccatgtaggtgttttatgcgacaatttgtct 1080 gaaactgttgatgaagcattgagattgttggatatgtcccctgacacttattttagtttg 1140 cacgctgaaaaagaagatggtacaccaatttccagttctttaccacctccattccctcca 1200 tgtaacttaagaacagccttgaccagatacgcttgcttgttatcatcccctaaaaagtcc 1260 gccttggttgctttagccgctcatgctagtgatcctactgaagcagaaagattgaaacac 1320 ttagcatctccagccggtaaagatgaatattcaaagtgggtagttgaatctcaaagatca 1380 ttgttagaagttatggcagaatttccatctgccaagcctccattaggtgtcttctttgct 1440 ggtgtagcacctagattgcaaccaagattctactcaatcagttcttcacctaagatcgct 1500 gaaactagaattcatgttacatgtgcattagtctacgaaaagatgccaaccggtagaatt 1560 cacaagggtgtatgctctacttggatgaaaaatgctgttccttacgaaaaatcagaaaag 1620 ttgttcttaggtagaccaatcttcgtaagacaatcaaacttcaagttgccttctgattca 1680 aaggttccaataatcatgataggtcctggtacaggtttagccccattcagaggtttcttg 1740 caagaaagattggctttagttgaatctggtgtcgaattaggtccttcagttttgttcttt 1800 ggttgtagaaacagaagaatggatttcatctatgaagaagaattgcaaagattcgtcgaa 1860 tctggtgcattggccgaattatctgtagctttttcaagagaaggtccaactaaggaatac 1920 gttcaacataagatgatggataaggcatccgacatatggaacatgatcagtcaaggtgct 1980 tatttgtacgtttgcggtgacgcaaagggtatggccagagatgtccatagatctttgcac 2040 acaattgctcaagaacaaggttccatggatagtaccaaagctgaaggtttcgtaaagaac 2100 ttacaaacttccggtagatacttgagagatgtctggtga 2139 SEQIDNO:190 MSSSSSSSTSMIDLMAAIIKGEPVIVSDPANASAYESVAAELSSMLIENRQFAMIVTTSI 60 AVLIGCIVMLVWRRSGSGNSKRVEPLKPLVIKPREEEIDDGRKKVTIFFGTQTGTAEGFA 120 KALGEEAKARYEKTRFKIVDLDDYAADDDEYEEKLKKEDVAFFFLATYGDGEPTDNAARF 180 YKWFTEGNDRGEWLKNLKYGVFGLGNRQYEHFNKVAKVVDDILVEQGAQRLVQVGLGDDD 240 QCIEDDFTAWREALWPELDTILREEGDTAVATPYTAAVLEYRVSIHDSEDAKFNDITLAN 300 GNGYTVFDAQHPYKANVAVKRELHTPESDRSCIHLEFDIAGSGLTMKLGDHVGVLCDNLS 360 ETVDEALRLLDMSPDTYFSLHAEKEDGTPISSSLPPPFPPCNLRTALTRYACLLSSPKKS 420 ALVALAAHASDPTEAERLKHLASPAGKDEYSKWVVESQRSLLEVMAEFPSAKPPLGVFFA 480 GVAPRLQPRFYSISSSPKIAETRIHVTCALVYEKMPTGRIHKGVCSTWMKNAVPYEKSEK 540 LFLGRPIFVRQSNFKLPSDSKVPIIMIGPGTGLAPFRGFLQERLALVESGVELGPSVLFF 600 GCRNRRMDFIYEEELQRFVESGALAELSVAFSREGPTKEYVQHKMMDKASDIWNMISQGA 660 YLYVCGDAKGMARDVHRSLHTIAQEQGSMDSTKAEGFVKNLQTSGRYLRDVW 712 SEQIDNO:191 atggaagcctcttacctatacatttctattttgcttttactggcatcatacctgttcacc 60 actcaacttagaaggaagagcgctaatctaccaccaaccgtgtttccatcaataccaatc 120 attggacacttatacttactcaaaaagcctctttatagaactttagcaaaaattgccgct 180 aagtacggaccaatactgcaattacaactcggctacagacgtgttctggtgatttcctca 240 ccatcagcagcagaagagtgctttaccaataacgatgtaatcttcgcaaatagacctaag 300 acattgtttggcaaaatagtgggtggaacatcccttggcagtttatcctacggcgatcaa 360 tggcgtaatctaaggagagtagcttctatcgaaatcctatcagttcataggttgaacgaa 420 tttcatgatatcagagtggatgagaacagattgttaattagaaaacttagaagttcatct 480 tctcctgttactcttataacagtcttttatgctctaacattgaacgtcattatgagaatg 540 atctctggcaaaagatatttcgacagtggggatagagaattggaggaggaaggtaagaga 600 tttcgagaaatcttagacgaaacgttgcttctagccggtgcttctaatgttggcgactac 660 ttaccaatattgaactggttgggagttaagtctcttgaaaagaaattgatcgctttgcag 720 aaaaagagagatgactttttccagggtttgattgaacaggttagaaaatctcgtggtgct 780 aaagtaggcaaaggtagaaaaacgatgatcgaactcttattatctttgcaagagtcagaa 840 cctgagtactatacagatgctatgataagatcttttgtcctaggtctgctggctgcaggt 900 agtgatacttcagcgggcactatggaatgggccatgagcttactggtcaatcacccacat 960 gtattgaagaaagctcaagctgaaatcgatagagttatcggtaataacagattgattgac 1020 gagtcagacattggaaatatcccttacatcgggtgtattatcaatgaaactctaagactc 1080 tatccagcagggccattgttgttcccacatgaaagttctgccgactgcgttatttccggt 1140 tacaatatacctagaggtacaatgttaatcgtaaaccaatgggcgattcatcacgatcct 1200 aaagtctgggatgatcctgaaacctttaaacctgaaagatttcaaggattagaaggaact 1260 agagatggtttcaaacttatgccattcggttctgggagaagaggatgtccaggtgaaggt 1320 ttggcaataaggctgttagggatgacactaggctcagtgatccaatgttttgattgggag 1380 agagtaggagatgagatggttgacatgacagaaggtttgggtgtcacacttcctaaggcc 1440 gttccattagttgccaaatgtaagccacgttccgaaatgactaatctcctatccgaactt 1500 taa 1503 SEQIDNO:192 MEASYLYISILLLLASYLFTTQLRRKSANLPPTVFPSIPIIGHLYLLKKPLYRTLAKIAA 60 KYGPILQLQLGYRRVLVISSPSAAEECFTNNDVIFANRPKTLFGKIVGGTSLGSLSYGDQ 120 WRNLRRVASIEILSVHRLNEFHDIRVDENRLLIRKLRSSSSPVTLITVFYALTLNVIMRM 180 ISGKRYFDSGDRELEEEGKRFREILDETLLLAGASNVGDYLPILNWLGVKSLEKKLIALQ 240 KKRDDFFQGLIEQVRKSRGAKVGKGRKTMIELLLSLQESEPEYYTDAMIRSFVLGLLAAG 300 SDTSAGTMEWAMSLLVNHPHVLKKAQAEIDRVIGNNRLIDESDIGNIPYIGCIINETLRL 360 YPAGPLLFPHESSADCVISGYNIPRGTMLIVNQWAIHHDPKVWDDPETFKPERFQGLEGT 420 RDGFKLMPFGSGRRGCPGEGLAIRLLGMTLGSVIQCFDWERVGDEMVDMTEGLGVTLPKA 480 VPLVAKCKPRSEMTNLLSEL 500 SEQIDNO:193 atgcaatctaactccgtgaagatttcgccgcttgatctggtaactgcgctgtttagcggc 60 aaggttttggacacatcgaacgcatcggaatcgggagaatctgctatgctgccgactata 120 gcgatgattatggagaatcgtgagctgttgatgatactcacaacgtcggttgctgtattg 180 atcggatgcgttgtcgttttggtgtggcggagatcgtctacgaagaagtcggcgttggag 240 ccaccggtgattgtggttccgaagagagtgcaagaggaggaagttgatgatggtaagaag 300 aaagttacggttttcttcggcacccaaactggaacagctgaaggcttcgctaaggcactt 360 gttgaggaagctaaagctcgatatgaaaaggctgtctttaaagtaattgatttggatgat 420 tatgctgctgatgacgatgagtatgaggagaaactaaagaaagaatctttggcctttttc 480 tttttggctacgtatggagatggtgagccaacagataatgctgccagattttataaatgg 540 tttactgagggagatgcgaaaggagaatggcttaataagcttcaatatggagtatttggt 600 ttgggtaacagacaatatgaacattttaacaagatcgcaaaagtggttgatgatggtctt 660 gtagaacagggtgcaaagcgtcttgttcctgttggacttggagatgatgatcaatgtatt 720 gaagatgacttcaccgcatggaaagagttagtatggccggagttggatcaattacttcgt 780 gatgaggatgacacaactgttgctactccatacacagctgctgttgcagaatatcgcgtt 840 gtttttcatgaaaaaccagacgcgctttctgaagattatagttatacaaatggccatgct 900 gttcatgatgctcaacatccatgcagatccaacgtggctgtcaaaaaggaacttcatagt 960 cctgaatctgaccggtcttgcactcatcttgaatttgacatctcgaacaccggactatca 1020 tatgaaactggggaccatgttggagtttactgtgaaaacttgagtgaagttgtgaatgat 1080 gctgaaagattagtaggattaccaccagacacttactcctccatccacactgatagtgaa 1140 gacgggtcgccacttggcggagcctcattgccgcctcctttcccgccatgcactttaagg 1200 aaagcattgacgtgttatgctgatgttttgagttctcccaagaagtcggctttgcttgca 1260 ctagctgctcatgccaccgatcccagtgaagctgatagattgaaatttcttgcatccccc 1320 gccggaaaggatgaatattctcaatggatagttgcaagccaaagaagtctccttgaagtc 1380 atggaagcattcccgtcagctaagccttcacttggtgttttctttgcatctgttgccccg 1440 cgcttacaaccaagatactactctatttcttcctcacccaagatggcaccggataggatt 1500 catgttacatgtgcattagtctatgagaaaacacctgcaggccgcatccacaaaggagtt 1560 tgttcaacttggatgaagaacgcagtgcctatgaccgagagtcaagattgcagttgggcc 1620 ccaatatacgtccgaacatccaatttcagactaccatctgaccctaaggtcccggttatc 1680 atgattggacctggcactggtttggctccttttagaggtttccttcaagagcggttagct 1740 ttaaaggaagccggaactgacctcggtttatccattttattcttcggatgtaggaatcgc 1800 aaagtggatttcatatatgaaaacgagcttaacaactttgtggagactggtgctctttct 1860 gagcttattgttgctttctcccgtgaaggcccgactaaggaatatgtgcaacacaagatg 1920 agtgagaaggcttcggatatctggaacttgctttctgaaggagcatatttatacgtatgt 1980 ggtgatgccaaaggcatggccaaagatgtacatcgaaccctccacacaattgtgcaagaa 2040 cagggatctcttgactcgtcaaaggcagaactctacgtgaagaatctacaaatgtcagga 2100 agatacctccgtgacgtttggtaa 2124 SEQIDNO:194 MQSNSVKISPLDLVTALFSGKVLDTSNASESGESAMLPTIAMIMENRELLMILTTSVAVL 60 IGCVVVLVWRRSSTKKSALEPPVIVVPKRVQEEEVDDGKKKVTVFFGTQTGTAEGFAKAL 120 VEEAKARYEKAVFKVIDLDDYAADDDEYEEKLKKESLAFFFLATYGDGEPTDNAARFYKW 180 FTEGDAKGEWLNKLQYGVFGLGNRQYEHFNKIAKVVDDGLVEQGAKRLVPVGLGDDDQCI 240 EDDFTAWKELVWPELDQLLRDEDDTTVATPYTAAVAEYRVVFHEKPDALSEDYSYTNGHA 300 VHDAQHPCRSNVAVKKELHSPESDRSCTHLEFDISNTGLSYETGDHVGVYCENLSEVVND 360 AERLVGLPPDTYSSIHTDSEDGSPLGGASLPPPFPPCTLRKALTCYADVLSSPKKSALLA 420 LAAHATDPSEADRLKFLASPAGKDEYSQWIVASQRSLLEVMEAFPSAKPSLGVFFASVAP 480 RLQPRYYSISSSPKMAPDRIHVTCALVYEKTPAGRIHKGVCSTWMKNAVPMTESQDCSWA 540 PIYVRTSNFRLPSDPKVPVIMIGPGTGLAPFRGFLQERLALKEAGTDLGLSILFFGCRNR 600 KVDFIYENELNNFVETGALSELIVAFSREGPTKEYVQHKMSEKASDIWNLLSEGAYLYVC 660 GDAKGMAKDVHRTLHTIVQEQGSLDSSKAELYVKNLQMSGRYLRDVW 707 SEQIDNO:195 atggatgcaatggcaactactgagaaaaagcctcatgtgatcttcattccatttcctgca 60 caatctcacataaaggcaatgctaaagttagcacaactattacaccataagggattacag 120 ataactttcgtgaataccgacttcatccataatcaatttctggaatctagtggccctcat 180 tgtttggacggagccccagggtttagattcgaaacaattcctgacggtgtttcacattcc 240 ccagaggcctccatcccaataagagagagtttactgaggtcaatagaaaccaactttttg 300 gatcgtttcattgacttggtcacaaaacttccagacccaccaacttgcataatctctgat 360 ggctttctgtcagtgtttactatcgacgctgccaaaaagttgggtatcccagttatgatg 420 tactggactcttgctgcatgcggtttcatgggtttctatcacatccattctcttatcgaa 480 aagggttttgctccactgaaagatgcatcatacttaaccaacggctacctggatactgtt 540 attgactgggtaccaggtatggaaggtataagacttaaagattttcctttggattggtct 600 acagaccttaatgataaagtattgatgtttactacagaagctccacaaagatctcataag 660 gtttcacatcatatctttcacacctttgatgaattggaaccatcaatcatcaaaaccttg 720 tctctaagatacaatcatatctacactattggtccattacaattacttctagatcaaatt 780 cctgaagagaaaaagcaaactggtattacatccttacacggctactctttagtgaaagag 840 gaaccagaatgttttcaatggctacaaagtaaagagcctaattctgtggtctacgtcaac 900 ttcggaagtacaacagtcatgtccttggaagatatgactgaatttggttggggccttgct 960 aattcaaatcattactttctatggattatcaggtccaatttggtaataggggaaaacgcc 1020 gtattacctccagaattggaggaacacatcaaaaagagaggtttcattgcttcctggtgt 1080 tctcaggaaaaggtattgaaacatccttctgttggtggtttccttactcattgcggttgg 1140 ggctctacaatcgaatcactaagtgcaggagttccaatgatttgttggccatattcatgg 1200 gaccaacttacaaattgtaggtatatctgtaaagagtgggaagttggattagaaatggga 1260 acaaaggttaaacgtgatgaagtgaaaagattggttcaggagttgatgggggaaggtggc 1320 cacaagatgagaaacaaggccaaagattggaaggaaaaagccagaattgctattgctcct 1380 aacgggtcatcctctctaaacattgataagatggtcaaagagattacagtcttagccaga 1440 aactaa 1446 SEQIDNO:196 MDAMATTEKKPHVIFIPFPAQSHIKAMLKLAQLLHHKGLQITFVNTDFIHNQFLESSGPH 60 CLDGAPGFRFETIPDGVSHSPEASIPIRESLLRSIETNFLDRFIDLVTKLPDPPTCIISD 120 GFLSVFTIDAAKKLGIPVMMYWTLAACGFMGFYHIHSLIEKGFAPLKDASYLTNGYLDTV 180 IDWVPGMEGIRLKDFPLDWSTDLNDKVLMFTTEAPQRSHKVSHHIFHTFDELEPSIIKTL 240 SLRYNHIYTIGPLQLLLDQIPEEKKQTGITSLHGYSLVKEEPECFQWLQSKEPNSVVYVN 300 FGSTTVMSLEDMTEFGWGLANSNHYFLWIIRSNLVIGENAVLPPELEEHIKKRGFIASWC 360 SQEKVLKHPSVGGFLTHCGWGSTIESLSAGVPMICWPYSWDQLTNCRYICKEWEVGLEMG 420 TKVKRDEVKRLVQELMGEGGHKMRNKAKDWKEKARIAIAPNGSSSLNIDKMVKEITVLAR 480 N 481 SEQIDNO:197 atggcggaacaacaaaagatcaagaaatcaccacacgttctactcatcccattcccttta 60 caaggccatataaaccctttcatccagtttggcaaacgattaatctccaaaggtgtcaaa 120 acaacacttgttaccaccatccacaccttaaactcaaccctaaaccacagtaacaccacc 180 accacctccatcgaaatccaagcaatttccgatggttgtgatgaaggcggttttatgagt 240 gcaggagaatcatatttggaaacattcaaacaagttgggtctaaatcactagctgactta 300 atcaagaagcttcaaagtgaaggaaccacaattgatgcaatcatttatgattctatgact 360 gaatgggttttagatgttgcaattgagtttggaatcgatggtggttcgtttttcactcaa 420 gcttgtgttgtaaacagcttatattatcatgttcataagggtttgatttctttgccattg 480 ggtgaaactgtttcggttcctggatttccagtgcttcaacggtgggagacaccgttaatt 540 ttgcagaatcatgagcaaatacagagcccttggtctcagatgttgtttggtcagtttgct 600 aatattgatcaagcacgttgggtcttcacaaatagtttttacaagctcgaggaagaggta 660 atagagtggacgagaaagatatggaacttgaaggtaatcgggccaacacttccatccatg 720 taccttgacaaacgacttgatgatgataaagataacggatttaatctctacaaagcaaac 780 catcatgagtgcatgaactggttagacgataagccaaaggaatcagttgtttacgtagca 840 tttggtagcctggtgaaacatggacccgaacaagtggaagaaatcacacgggctttaata 900 gatagtgatgtcaacttcttgtgggttatcaaacataaagaagagggaaagctcccagaa 960 aatctttcggaagtaataaaaaccggaaagggtttgattgtagcatggtgcaaacaattg 1020 gatgtgttagcacacgaatcagtaggatgctttgttacacattgtgggttcaactcaact 1080 cttgaagcaataagtcttggagtccccgttgttgcaatgcctcaattttcggatcaaact 1140 acaaatgccaagcttctagatgaaattttgggtgttggagttagagttaaggctgatgag 1200 aatgggatagtgagaagaggaaatcttgcgtcatgtattaagatgattatggaggaggaa 1260 agaggagtaataatccgaaagaatgcggtaaaatggaaggatttggctaaagtagccgtt 1320 catgaaggtggtagctcagacaatgatattgtcgaatttgtaagtgagctaattaaggct 1380 taaatttttgttgctttgtattttatgtgttatggttttttgatttagatgtattcaatt 1440 aatattgaatcataactaaattcaagattattgtttgtaatattctttgtcctaaaattt 1500 tgcgacttaaaacctttagtttataaaaagaaattagaaaatactattgcacgga 1555 SEQIDNO:198 MAEQQKIKKSPHVLLIPFPLQGHINPFIQFGKRLISKGVKTTLVTTIHTLNSTLNHSNTT 60 TTSIEIQAISDGCDEGGFMSAGESYLETFKQVGSKSLADLIKKLQSEGTTIDAIIYDSMT 120 EWVLDVAIEFGIDGGSFFTQACVVNSLYYHVHKGLISLPLGETVSVPGFPVLQRWETPLI 180 LQNHEQIQSPWSQMLFGQFANIDQARWVFTNSFYKLEEEVIEWTRKIWNLKVIGPTLPSM 240 YLDKRLDDDKDNGFNLYKANHHECMNWLDDKPKESVVYVAFGSLVKHGPEQVEEITRALI 300 DSDVNFLWVIKHKEEGKLPENLSEVIKTGKGLIVAWCKQLDVLAHESVGCFVTHCGFNST 360 LEAISLGVPVVAMPQFSDQTTNAKLLDEILGVGVRVKADENGIVRRGNLASCIKMIMEEE 420 RGVIIRKNAVKWKDLAKVAVHEGGSSDNDIVEFVSELIKA 460 SEQIDNO:199 atggaaaacaagaccgaaacaacagttagacgtaggcgtagaatcattctgtttccagta 60 ccttttcaagggcacatcaatccaatactacaactagccaacgttttgtactctaaaggt 120 ttttctattacaatctttcacaccaatttcaacaaaccaaaaacatccaattacccacat 180 ttcacattcagattcatacttgataatgatccacaagatgaacgtatttcaaacttacct 240 acccacggtcctttagctggaatgagaattccaatcatcaatgaacatggtgccgatgag 300 cttagaagagaattagagttacttatgttggcatccgaagaggacgaggaagtctcttgt 360 ctgattactgacgctctatggtactttgcccaatctgtggctgatagtttgaatttgagg 420 agattggtactaatgacatccagtctgtttaactttcacgctcatgttagtttaccacaa 480 tttgacgaattgggatacttggaccctgatgacaagactaggttagaggaacaggcctct 540 ggttttcctatgttgaaagtcaaagatatcaagtctgcctattctaattggcaaatcttg 600 aaagagatcttaggaaagatgatcaaacagacaaaggcttcatctggagtgatttggaac 660 agtttcaaagagttagaagagtctgaattggagactgtaatcagagaaattccagcacct 720 tcattcctgataccattaccaaaacatttgactgcttcctcttcctctttgttggatcat 780 gacagaacagtttttcaatggttggaccaacaaccacctagttctgttttgtacgtgtca 840 tttggtagtacttctgaagtcgatgaaaaggacttccttgaaatcgcaagaggcttagtc 900 gatagtaagcagtcattcctttgggtcgtgcgtccaggtttcgtgaaaggctcaacatgg 960 gtcgaaccacttccagatggttttctaggcgaaagaggtagaatagtcaaatgggttcct 1020 caacaggaagttttagctcatggcgctattggggcattctggactcattccggatggaat 1080 tcaactttagaatcagtatgcgaaggggtacctatgatcttttcagattttggtcttgat 1140 caaccactgaacgcaagatacatgtctgatgttttgaaagtgggtgtatatctagaaaat 1200 ggctgggaaaggggtgaaatagctaatgcaataagacgtgttatggttgatgaagagggg 1260 gagtatatcagacaaaacgcaagagtgctgaagcaaaaggccgacgtttctctaatgaag 1320 ggaggctcttcatacgaatccttagaatctcttgtttcctacatttcatcactgtaa 1377 SEQIDNO:200 MENKTETTVRRRRRIILFPVPFQGHINPILQLANVLYSKGFSITIFHTNFNKPKTSNYPH 60 FTFRFILDNDPQDERISNLPTHGPLAGMRIPIINEHGADELRRELELLMLASEEDEEVSC 120 LITDALWYFAQSVADSLNLRRLVLMTSSLFNFHAHVSLPQFDELGYLDPDDKTRLEEQAS 180 GFPMLKVKDIKSAYSNWQILKEILGKMIKQTKASSGVIWNSFKELEESELETVIREIPAP 240 SFLIPLPKHLTASSSSLLDHDRTVFQWLDQQPPSSVLYVSFGSTSEVDEKDFLEIARGLV 300 DSKQSFLWVVRPGFVKGSTWVEPLPDGFLGERGRIVKWVPQQEVLAHGAIGAFWTHSGWN 360 STLESVCEGVPMIFSDFGLDQPLNARYMSDVLKVGVYLENGWERGEIANAIRRVMVDEEG 420 EYIRQNARVLKQKADVSLMKGGSSYESLESLVSYISSL 458 SEQIDNO:201 atggctacttctgattccatcgttgacgatagaaagcaattgcatgttgctacttttcca 60 tggttggctttcggtcatattttgccatacttgcaattgtccaagttgattgctgaaaag 120 ggtcacaaggtttcattcttgtctaccaccagaaacatccaaagattgtcctctcatatc 180 tccccattgatcaacgttgttcaattgactttgccaagagtccaagaattgccagaagat 240 gctgaagctactactgatgttcatccagaagatatcccttacttgaaaaaggcttccgat 300 ggtttacaaccagaagttactagattcttggaacaacattccccagattggatcatctac 360 gattatactcattactggttgccatccattgctgcttcattgggtatttctagagcccat 420 ttctctgttactactccatgggctattgcttatatgggtccatctgctgatgctatgatt 480 aacggttctgatggtagaactaccgttgaagatttgactactccaccaaagtggtttcca 540 tttccaacaaaagtctgttggagaaaacacgatttggctagattggttccatacaaagct 600 ccaggtatttctgatggttacagaatgggtatggttttgaaaggttccgattgcttgttg 660 tctaagtgctatcatgaattcggtactcaatggttgcctttgttggaaacattgcatcaa 720 gttccagttgttccagtaggtttgttgccaccagaaattccaggtgacgaaaaagacgaa 780 acttgggtttccatcaaaaagtggttggatggtaagcaaaagggttctgttgtttatgtt 840 gctttgggttccgaagctttggtttctcaaaccgaagttgttgaattggctttgggtttg 900 gaattgtctggtttgccatttgtttgggcttacagaaaacctaaaggtccagctaagtct 960 gattctgttgaattgccagatggtttcgttgaaagaactagagatagaggtttggtttgg 1020 acttcttgggctccacaattgagaattttgtctcatgaatccgtctgtggtttcttgact 1080 cattgtggttctggttctatcgttgaaggtttgatgtttggtcacccattgattatgttg 1140 ccaatctttggtgaccaaccattgaacgctagattattggaagataagcaagtcggtatc 1200 gaaatcccaagaaatgaagaagatggttgcttgaccaaagaatctgttgctagatctttg 1260 agatccgttgtcgttgaaaaagaaggtgaaatctacaaggctaacgctagagaattgtcc 1320 aagatctacaacgataccaaggtcgaaaaagaatacgtttcccaattcgttgactacttg 1380 gaaaagaatgctagagctgttgccattgatcatgaatcttga 1422 SEQIDNO:202 MATSDSIVDDRKQLHVATFPWLAFGHILPYLQLSKLIAEKGHKVSFLSTTRNIQRLSSHI 60 SPLINVVQLTLPRVQELPEDAEATTDVHPEDIPYLKKASDGLQPEVTRFLEQHSPDWIIY 120 DYTHYWLPSIAASLGISRAHFSVTTPWAIAYMGPSADAMINGSDGRTTVEDLTTPPKWFP 180 FPTKVCWRKHDLARLVPYKAPGISDGYRMGMVLKGSDCLLSKCYHEFGTQWLPLLETLHQ 240 VPVVPVGLLPPEIPGDEKDETWVSIKKWLDGKQKGSVVYVALGSEALVSQTEVVELALGL 300 ELSGLPFVWAYRKPKGPAKSDSVELPDGFVERTRDRGLVWTSWAPQLRILSHESVCGFLT 360 HCGSGSIVEGLMFGHPLIMLPIFGDQPLNARLLEDKQVGIEIPRNEEDGCLTKESVARSL 420 RSVVVEKEGEIYKANARELSKIYNDTKVEKEYVSQFVDYLEKNARAVAIDHES 473 SEQIDNO:203 atggatagtggctactcctcatcttatgctgctgccgctggtatgcacgttgtgatctgc 60 ccttggttggcctttggtcacctgttaccatgtctggatttagcccaaagactggcctca 120 agaggccatagagtatcatttgtgtctactcctagaaatatctctcgtttaccaccagtc 180 agacctgctctagctcctctagttgcattcgttgctcttccacttccaagagtagaagga 240 ttgccagacggcgctgaatctactaatgacgtaccacatgatagacctgacatggtcgaa 300 ttgcatagaagagcctttgatggattggcagctccattttctgagttcctgggcacagca 360 tgtgcagactgggttatagtcgatgtatttcatcactgggctgctgcagccgcattggaa 420 cataaggtgccttgtgctatgatgttgttagggtcagcacacatgatcgcatccatagct 480 gatagaagattggaaagagctgaaacagaatccccagccgcagcaggacaaggtaggcca 540 gctgccgccccaacctttgaagtggctagaatgaaattgattcgtactaaaggtagttca 600 gggatgagtcttgctgaaaggttttctctgacattatctagatcatcattagttgtaggt 660 agatcctgcgtcgagttcgaacctgaaacagtacctttactatctactttgagaggcaaa 720 cctattactttccttggtctaatgcctccattacatgaaggaaggagagaagatggtgaa 780 gatgctactgttaggtggttagatgcccaacctgctaagtctgttgtttacgttgcattg 840 ggttctgaggtaccactaggggtggaaaaggtgcatgaattagcattaggacttgagctg 900 gccggaacaagattcctttgggctttgagaaaaccaaccggtgtttctgacgccgacttg 960 ctaccagctgggttcgaagagagaacaagaggccgtggtgtcgttgctactagatgggtc 1020 ccacaaatgagtattctagctcatgcagctgtaggggcctttctaacccattgcggttgg 1080 aactcaacaatagaaggactgatgtttggtcatccacttattatgttaccaatctttggc 1140 gatcagggacctaacgcaagattgattgaggcaaagaacgcaggtctgcaggttgcacgt 1200 aatgatggtgatggttcctttgatagagaaggcgttgcagctgccatcagagcagtcgcc 1260 gttgaggaagagtcatctaaagttttccaagctaaggccaaaaaattacaagagattgtg 1320 gctgacatggcttgtcacgaaagatacatcgatggtttcatccaacaattgagaagttat 1380 aaagactaa 1389 SEQIDNO:204 MDSGYSSSYAAAAGMHVVICPWLAFGHLLPCLDLAQRLASRGHRVSFVSTPRNISRLPPV 60 RPALAPLVAFVALPLPRVEGLPDGAESTNDVPHDRPDMVELHRRAFDGLAAPFSEFLGTA 120 CADWVIVDVFHHWAAAAALEHKVPCAMMLLGSAHMIASIADRRLERAETESPAAAGQGRP 180 AAAPTFEVARMKLIRTKGSSGMSLAERFSLTLSRSSLVVGRSCVEFEPETVPLLSTLRGK 240 PITFLGLMPPLHEGRREDGEDATVRWLDAQPAKSVVYVALGSEVPLGVEKVHELALGLEL 300 AGTRFLWALRKPTGVSDADLLPAGFEERTRGRGVVATRWVPQMSILAHAAVGAFLTHCGW 360 NSTIEGLMFGHPLIMLPIFGDQGPNARLIEAKNAGLQVARNDGDGSFDREGVAAAIRAVA 420 VEEESSKVFQAKAKKLQEIVADMACHERYIDGFIQQLRSYKD 462 SEQIDNO:205 atggctaccttgttggaacattttcaagctatgccattcgctattccaattgctttggct 60 gctttgtcttggttgtttttgttctacatcaaggtttctttcttctccaacaaatccgct 120 caagctaaattgccaccagttccagttgttccaggtttgccagttattggtaatttgttg 180 caattgaaagaaaagaagccataccaaaccttcactagatgggctgaagaatatggtcca 240 atctactctattagaactggtgcttctactatggttgtcttgaacactactcaagttgcc 300 aaagaagctatggttaccagatacttgtctatctctaccagaaagttgtccaacgccttg 360 aaaattttgaccgctgataagtgcatggttgccatttctgattacaacgatttccacaag 420 atgatcaagagatatatcttgtctaacgttttgggtccatctgcccaaaaaagacataga 480 tctaacagagataccttgagagccaacgtttgttctagattgcattcccaagttaagaac 540 tctccaagagaagctgtcaactttagaagagttttcgaatgggaattattcggtatcgct 600 ttgaaacaagccttcggtaaggatattgaaaagccaatctacgtcgaagaattgggtact 660 actttgtccagagatgaaatcttcaaggttttggtcttggacattatggaaggtgccatt 720 gaagttgattggagagattttttcccatacttgcgttggattccaaacaccagaatggaa 780 actaagatccaaagattatactttagaagaaaggccgttatgaccgccttgattaacgaa 840 caaaagaaaagaattgcctccggtgaagaaatcaactgctacatcgatttcttgttgaaa 900 gaaggtaagaccttgaccatggaccaaatctctatgttgttgtgggaaaccgttattgaa 960 actgctgataccacaatggttactactgaatgggctatgtacgaagttgctaaggattct 1020 aaaagacaagacagattataccaagaaatccaaaaggtctgcggttctgaaatggttaca 1080 gaagaatacttgtcccaattgccatacttgaatgctgttttccacgaaactttgagaaaa 1140 cattctccagctgctttggttccattgagatatgctcatgaagatactcaattgggtggt 1200 tattacattccagccggtactgaaattgccattaacatctacggttgcaacatggacaaa 1260 caccaatgggaatctccagaagaatggaagccagaaagatttttggatcctaagtttgac 1320 ccaatggacttgtacaaaactatggcttttggtgctggtaaaagagtttgcgctggttct 1380 ttacaagctatgttgattgcttgtccaaccatcggtagattggttcaagaatttgaatgg 1440 aagttgagagatggtgaagaagaaaacgttgatactgttggtttgaccacccataagaga 1500 tatccaatgcatgctattttgaagccaagatcttaa 1536 SEQIDNO:206 MATLLEHFQAMPFAIPIALAALSWLFLFYIKVSFFSNKSAQAKLPPVPVVPGLPVIGNLL 60 QLKEKKPYQTFTRWAEEYGPIYSIRTGASTMVVLNTTQVAKEAMVTRYLSISTRKLSNAL 120 KILTADKCMVAISDYNDFHKMIKRYILSNVLGPSAQKRHRSNRDTLRANVCSRLHSQVKN 180 SPREAVNFRRVFEWELFGIALKQAFGKDIEKPIYVEELGTTLSRDEIFKVLVLDIMEGAI 240 EVDWRDFFPYLRWIPNTRMETKIQRLYFRRKAVMTALINEQKKRIASGEEINCYIDFLLK 300 EGKTLTMDQISMLLWETVIETADTTMVTTEWAMYEVAKDSKRQDRLYQEIQKVCGSEMVT 360 EEYLSQLPYLNAVFHETLRKHSPAALVPLRYAHEDTQLGGYYIPAGTEIAINIYGCNMDK 420 HQWESPEEWKPERFLDPKFDPMDLYKTMAFGAGKRVCAGSLQAMLIACPTIGRLVQEFEW 480 KLRDGEEENVDTVGLTTHKRYPMHAILKPRS 511 SEQIDNO:207 atggctttggtaaacccaaccgctcttttctatggtacctctatcagaacaagacctaca 60 aacttactaaatccaactcaaaagctaagaccagtttcatcatcttccttaccttctttc 120 tcatcagttagtgcgattcttactgaaaaacatcaatctaatccttctgagaacaacaat 180 ttgcaaactcatctagaaactcctttcaactttgatagttatatgttggaaaaagtcaac 240 atggttaacgaggcgcttgatgcatctgtcccactaaaagacccaatcaaaatccatgaa 300 tccatgagatactctttattggcaggcggtaagagaatcagaccaatgatgtgtattgca 360 gcctgcgaaatagtcggaggtaatatccttaacgccatgccagccgcatgtgccgtggaa 420 atgattcatactatgtctttggtgcatgacgatcttccatgtatggataatgatgacttc 480 agaagaggtaaacctatttcacacaaggtctacggggaggaaatggcagtattgaccggc 540 gatgctttactaagtttatctttcgaacatatagctactgctacaaagggtgtatcaaag 600 gatagaatcgtcagagctataggggagttggcccgttcagttggctccgaaggtttagtg 660 gctggacaagttgtagatatcttgtcagagggtgctgatgttggattagatcacctagaa 720 tacattcacatccacaaaacagcaatgttgcttgagtcctcagtagttattggcgctatc 780 atgggaggaggatctgatcagcagatcgaaaagttgagaaaattcgctagatctattggt 840 ctactattccaagttgtggatgacattttggatgttacaaaatctaccgaagagttgggg 900 aaaacagctggtaaggatttgttgacagataagacaacttacccaaagttgttaggtata 960 gaaaagtccagagaatttgccgaaaaacttaacaaggaagcacaagagcaattaagtggc 1020 tttgatagacgtaaggcagctcctttgatcgcgttagccaactacaatgcgtaccgtcaa 1080 aattga 1086 SEQIDNO:208 MALVNPTALFYGTSIRTRPTNLLNPTQKLRPVSSSSLPSFSSVSAILTEKHQSNPSENNN 60 LQTHLETPFNFDSYMLEKVNMVNEALDASVPLKDPIKIHESMRYSLLAGGKRIRPMMCIA 120 ACEIVGGNILNAMPAACAVEMIHTMSLVHDDLPCMDNDDFRRGKPISHKVYGEEMAVLTG 180 DALLSLSFEHIATATKGVSKDRIVRAIGELARSVGSEGLVAGQVVDILSEGADVGLDHLE 240 YIHIHKTAMLLESSVVIGAIMGGGSDQQIEKLRKFARSIGLLFQVVDDILDVTKSTEELG 300 KTAGKDLLTDKTTYPKLLGIEKSREFAEKLNKEAQEQLSGFDRRKAAPLIALANYNAYRQ 360 N 361 SEQIDNO:209 atggctgagcaacaaatatctaacttgctgtctatgtttgatgcttcacatgctagtcag 60 aaattagaaattactgtccaaatgatggacacataccattacagagaaacgcctccagat 120 tcctcatcttctgaaggcggttcattgtctagatacgacgagagaagagtctctttgcct 180 ctcagtcataatgctgcctctccagatattgtatcacaactatgtttttccactgcaatg 240 tcttcagagttgaatcacagatggaaatctcaaagattaaaggtggccgattctccttac 300 aactatatcctaacattaccatcaaaaggaattagaggtgcctttatcgattccctgaac 360 gtatggttggaggttccagaggatgaaacatcagtcatcaaggaagttattggtatgctc 420 cacaactcttcattaatcattgatgacttccaagataattctccacttagaagaggaaag 480 ccatctacccatacagtcttcggccctgcccaggctatcaatactgctacttacgttata 540 gttaaagcaatcgaaaagatacaagacatagtgggacacgatgcattggcagatgttacg 600 ggtactattacaactattttccaaggtcaggccatggacttgtggtggacagcaaatgca 660 atcgttccatcaatacaggaatacttacttatggtaaacgataaaaccggtgctctcttt 720 agactgagtttggagttgttagctctgaattccgaagccagtatttctgactctgcttta 780 gaaagtttatctagtgctgtttccttgctaggtcaatacttccaaatcagagacgactat 840 atgaacttgatcgataacaagtatacagatcagaaaggcttctgcgaagatcttgatgaa 900 ggcaagtactcactaacacttattcatgccctccaaactgattcatccgatctactgacc 960 aacatcctttcaatgagaagagtgcaaggaaagttaacggcacaaaagagatgttggttc 1020 tggaaatga 1029 SEQIDNO:210 MAEQQISNLLSMFDASHASQKLEITVQMMDTYHYRETPPDSSSSEGGSLSRYDERRVSLP 60 LSHNAASPDIVSQLCFSTAMSSELNHRWKSQRLKVADSPYNYILTLPSKGIRGAFIDSLN 120 VWLEVPEDETSVIKEVIGMLHNSSLIIDDFQDNSPLRRGKPSTHTVFGPAQAINTATYVI 180 VKAIEKIQDIVGHDALADVTGTITTIFQGQAMDLWWTANAIVPSIQEYLLMVNDKTGALF 240 RLSLELLALNSEASISDSALESLSSAVSLLGQYFQIRDDYMNLIDNKYTDQKGFCEDLDE 300 GKYSLTLIHALQTDSSDLLTNILSMRRVQGKLTAQKRCWFWK 342 SEQIDNO:211 atggaaaagactaaggagaaagcagaacgtatcttgctggagccatacagatacttatta 60 caactaccaggaaagcaagtccgttctaaactatcacaagcgttcaatcactggttaaaa 120 gttcctgaagataagttacaaatcattattgaagtcacagaaatgctacacaatgcttct 180 ttactgatcgatgatatagaggattcttccaaactgagaagaggttttcctgtcgctcat 240 tccatatacggggtaccaagtgtaatcaactcagctaattacgtctacttcttgggattg 300 gaaaaagtattgacattagatcatccagacgctgtaaagctattcaccagacaacttctt 360 gaattgcatcaaggtcaaggtttggatatctattggagagacacttatacttgcccaaca 420 gaagaggagtacaaagcaatggttctacaaaagactggcggtttgttcggacttgccgtt 480 ggtctgatgcaacttttctctgattacaaggaggacttaaagcctctgttggataccttg 540 ggcttgtttttccagattagagatgactacgctaacttacattcaaaggaatattcagaa 600 aacaaatcattctgtgaagatttgactgaagggaagtttagttttccaacaatccacgcc 660 atttggtcaagaccagaatctactcaagtgcaaaacattctgcgtcagagaacagagaat 720 attgacatcaaaaagtattgtgttcagtacttggaagatgttggttcttttgcttacaca 780 agacatacacttagagaattagaggcaaaagcatacaagcaaatagaagcctgtggaggc 840 aatccttctctagtggcattggttaaacatttgtccaaaatgttcaccgaggaaaacaag 900 taa 903 SEQIDNO:212 MEKTKEKAERILLEPYRYLLQLPGKQVRSKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS 60 LLIDDIEDSSKLRRGFPVAHSIYGVPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL 120 ELHQGQGLDIYWRDTYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLDTL 180 GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN 240 IDIKKYCVQYLEDVGSFAYTRHTLRELEAKAYKQIEACGGNPSLVALVKHLSKMFTEENK 300 SEQIDNO:213 atggcaagattctattttcttaacgcactattgatggttatctcattacaatcaactaca 60 gccttcactccagctaaacttgcttatccaacaacaacaacagctctaaatgtcgcctcc 120 gccgaaacttctttcagtctagatgaatacttggcctctaagataggacctatagagtct 180 gccttggaagcatcagtcaaatccagaattccacagaccgataagatctgcgaatctatg 240 gcctactctttgatggcaggaggcaagagaattagaccagtgttgtgtatcgctgcatgt 300 gagatgttcggtggatcccaagatgtcgctatgcctactgctgtggcattagaaatgata 360 cacacaatgtctttgattcatgatgatttgccatccatggataacgatgacttgagaaga 420 ggtaaaccaacaaaccatgtcgttttcggcgaagatgtagctattcttgcaggtgactct 480 ttattgtcaacttccttcgagcacgtcgctagagaaacaaaaggagtgtcagcagaaaag 540 atcgtggatgttatcgctagattaggcaaatctgttggtgccgagggccttgctggcggt 600 caagttatggacttagaatgtgaagctaaaccaggtaccacattagacgacttgaaatgg 660 attcatatccataaaaccgctacattgttacaagttgctgtagcttctggtgcagttcta 720 ggtggtgcaactcctgaagaggttgctgcatgcgagttgtttgctatgaatataggtctt 780 gcctttcaagttgccgacgatatccttgatgtaaccgcttcatcagaagatttgggtaaa 840 actgcaggcaaagatgaagctactgataagacaacttacccaaagttattaggattagaa 900 gagagtaaggcatacgcaagacaactaatcgatgaagccaaggaaagtttggctcctttt 960 ggagatagagctgcccctttattggccattgcagatttcattattgatagaaagaattga 1020 SEQIDNO:214 MARFYFLNALLMVISLQSTTAFTPAKLAYPTTTTALNVASAETSFSLDEYLASKIGPIES 60 ALEASVKSRIPQTDKICESMAYSLMAGGKRIRPVLCIAACEMFGGSQDVAMPTAVALEMI 120 HTMSLIHDDLPSMDNDDLRRGKPTNHVVFGEDVAILAGDSLLSTSFEHVARETKGVSAEK 180 IVDVIARLGKSVGAEGLAGGQVMDLECEAKPGTTLDDLKWIHIHKTATLLQVAVASGAVL 240 GGATPEEVAACELFAMNIGLAFQVADDILDVTASSEDLGKTAGKDEATDKTTYPKLLGLE 300 ESKAYARQLIDEAKESLAPFGDRAAPLLAIADFIIDRKN 339 SEQIDNO:215 atgcacttagcaccacgtagagtccctagaggtagaagatcaccacctgacagagttcct 60 gaaagacaaggtgccttgggtagaagacgtggagctggctctactggctgtgcccgtgct 120 gctgctggtgttcaccgtagaagaggaggaggcgaggctgatccatcagctgctgtgcat 180 agaggctggcaagccggtggtggcaccggtttgcctgatgaggtggtgtctaccgcagcc 240 gccttagaaatgtttcatgcttttgctttaatccatgatgatatcatggatgatagtgca 300 actagaagaggctccccaactgttcacagagccctagctgatcgtttaggcgctgctctg 360 gacccagatcaggccggtcaactaggagtttctactgctatcttggttggagatctggct 420 ttgacatggtccgatgaattgttatacgctccattgactccacatagactggcagcagta 480 ctaccattggtaacagctatgagagctgaaaccgttcatggccaatatcttgatataact 540 agtgctagaagacctgggaccgatacttctcttgcattgagaatagccagatataagaca 600 gcagcttacacaatggaacgtccactgcacattggtgcagccctggctggggcaagacca 660 gaactattagcagggctttcagcatacgccttgccagctggagaagccttccaattggca 720 gatgacctgctaggcgtcttcggtgatccaagacgtacagggaaacctgacctagatgat 780 cttagaggtggaaagcatactgtcttagtcgccttggcaagagaacatgccactccagaa 840 cagagacacacattggatacattattgggtacaccaggtcttgatagacaaggcgcttca 900 agactaagatgcgtattggtagcaactggtgcaagagccgaagccgaaagacttattaca 960 gagagaagagatcaagcattaactgcattgaacgcattaacactgccacctcctttagct 1020 gaggcattagcaagattgacattagggtctacagctcatcctgcctaa 1068 SEQIDNO:216 MHLAPRRVPRGRRSPPDRVPERQGALGRRRGAGSTGCARAAAGVHRRRGGGEADPSAAVH 60 RGWQAGGGTGLPDEVVSTAAALEMFHAFALIHDDIMDDSATRRGSPTVHRALADRLGAAL 120 DPDQAGQLGVSTAILVGDLALTWSDELLYAPLTPHRLAAVLPLVTAMRAETVHGQYLDIT 180 SARRPGTDTSLALRIARYKTAAYTMERPLHIGAALAGARPELLAGLSAYALPAGEAFQLA 240 DDLLGVFGDPRRTGKPDLDDLRGGKHTVLVALAREHATPEQRHTLDTLLGTPGLDRQGAS 300 RLRCVLVATGARAEAERLITERRDQALTALNALTLPPPLAEALARLTLGSTAHPA 355 SEQIDNO:217 atgtcatatttcgataactacttcaatgagatagttaattccgtgaacgacatcattaag 60 tcttacatctctggcgacgtaccaaaactatacgaagcctcctaccatttgtttacatca 120 ggaggaaagagactaagaccattgatccttacaatttcttctgatcttttcggtggacag 180 agagaaagagcatactatgctggcgcagcaatcgaagttttgcacacattcactttggtt 240 cacgatgatatcatggatcaagataacattcgtagaggtcttcctactgtacatgtcaag 300 tatggcctacctttggccattttagctggtgacttattgcatgcaaaagcctttcaattg 360 ttgactcaggcattgagaggtctaccatctgaaactatcatcaaggcgtttgatatcttt 420 acaagatctatcattatcatatcagaaggtcaagctgtcgatatggaattcgaagataga 480 attgatatcaaggaacaagagtatttggatatgatatctcgtaaaaccgctgccttattc 540 tcagcttcttcttccattggggcgttgatagctggagctaatgataacgatgtgagatta 600 atgtccgatttcggtacaaatcttgggatcgcatttcaaattgtagatgatatacttggt 660 ttaacagctgatgaaaaagagctaggaaaacctgttttcagtgatatcagagaaggtaaa 720 aagaccatattagtcattaagactttagaattgtgtaaggaagacgagaaaaagattgtg 780 ttaaaagcgctaggcaacaagtcagcatcaaaggaagagttgatgagttctgctgacata 840 atcaaaaagtactcattggattacgcctacaacttagctgagaaatactacaaaaacgcc 900 atcgattctctaaatcaagtttcaagtaaaagtgatattccagggaaggcattgaaatat 960 cttgctgaattcaccatcagaagacgtaagtaa 993 SEQIDNO:218 MSYFDNYFNEIVNSVNDIIKSYISGDVPKLYEASYHLFTSGGKRLRPLILTISSDLFGGQ 60 RERAYYAGAAIEVLHTFTLVHDDIMDQDNIRRGLPTVHVKYGLPLAILAGDLLHAKAFQL 120 LTQALRGLPSETIIKAFDIFTRSIIIISEGQAVDMEFEDRIDIKEQEYLDMISRKTAALF 180 SASSSIGALIAGANDNDVRLMSDFGTNLGIAFQIVDDILGLTADEKELGKPVFSDIREGK 240 KTILVIKTLELCKEDEKKIVLKALGNKSASKEELMSSADIIKKYSLDYAYNLAEKYYKNA 300 IDSLNQVSSKSDIPGKALKYLAEFTIRRRK 330 SEQIDNO:219 atggcctctgttactttgggttcctggatcgtcgtccaccaccataaccatcaccatcca 60 tcatctatcctaactaaatctcgttcaagatcctgtcctattacactaaccaaaccaatc 120 tcttttcgttcaaagagaacagtttcctctagtagttctatcgtgtcctctagtgtcgtc 180 actaaggaagacaatctgagacagtctgaaccttcttcctttgatttcatgtcatatatc 240 attactaaggcagaactagtgaataaggctcttgattcagcagttccattaagagagcca 300 ttgaaaatccatgaagcaatgagatactctcttctagctggcgggaagagagtcagacct 360 gtactctgcatagcagcgtgcgaattagttggtggcgaggaatcaaccgctatgcctgcc 420 gcttgtgctgtagaaatgattcatacaatgtcactgatacacgatgatttgccatgtatg 480 gataacgatgatctgagaaggggtaagccaactaaccataaggttttcggcgaagatgtt 540 gccgtcttagctggtgatgctttgttatctttcgcgttcgaacatttggcatccgcaaca 600 tcaagtgatgttgtgtcaccagtaagagtagttagagcagttggagaactggctaaagct 660 attggaactgagggtttagttgcaggtcaagtcgtcgatatctcttccgaaggtcttgat 720 ttgaatgatgtaggtcttgaacatctcgaattcatccatcttcacaagacagctgcactt 780 ttagaagccagtgcggttctcggcgcaattgttggcggagggagtgatgacgaaattgag 840 agattgaggaagtttgctagatgtataggattactgttccaagtagtagacgatatacta 900 gatgtgacaaagtcttccaaagagttgggaaaaacagctggtaaagatttgattgccgac 960 aaattgacctaccctaagattatggggctagaaaaatcaagagaatttgccgagaaactc 1020 aatagagaggcgcgtgatcaactgttgggtttcgattctgataaagttgcaccactctta 1080 gccttagccaactacatcgcttacagacaaaactaa 1116 SEQIDNO:220 MASVTLGSWIVVHHHNHHHPSSILTKSRSRSCPITLTKPISFRSKRTVSSSSSIVSSSVV 60 TKEDNLRQSEPSSFDFMSYIITKAELVNKALDSAVPLREPLKIHEAMRYSLLAGGKRVRP 120 VLCIAACELVGGEESTAMPAACAVEMIHTMSLIHDDLPCMDNDDLRRGKPTNHKVFGEDV 180 AVLAGDALLSFAFEHLASATSSDVVSPVRVVRAVGELAKAIGTEGLVAGQVVDISSEGLD 240 LNDVGLEHLEFIHLHKTAALLEASAVLGAIVGGGSDDEIERLRKFARCIGLLFQVVDDIL 300 DVTKSSKELGKTAGKDLIADKLTYPKIMGLEKSREFAEKLNREARDQLLGFDSDKVAPLL 360 ALANYIAYRQN 371 SEQIDNO:221 atgaaaaccgggtttatctcaccagcaacagtatttcatcacagaatctcaccagcgacc 60 actttcagacatcacttatcacctgctactacaaactctacaggcattgtcgccttaaga 120 gacatcaacttcagatgtaaagcagtttctaaagagtactctgatctgttgcagaaagat 180 gaggcttctttcacaaaatgggacgatgacaaggtgaaagatcatcttgataccaacaaa 240 aacttatacccaaatgatgagattaaggaatttgttgaatcagtaaaggctatgttcggt 300 agtatgaatgacggggagataaacgtctctgcatacgatactgcatgggttgctttggtt 360 caagatgtcgatggatcaggtagtcctcagttcccttcttctttagaatggattgccaac 420 aatcaattgtcagatggatcatggggagatcatttgctgttctcagctcacgatagaatc 480 atcaacacattagcatgcgttattgcacttacaagttggaatgttcatccttctaagtgt 540 gaaaaaggtttgaattttctgagagaaaacatttgcaaattagaagatgaaaacgcagaa 600 catatgccaattggttttgaagtaacattcccatcactaattgatatcgcgaaaaagttg 660 aacattgaagtacctgaggatactccagcacttaaagagatctacgcacgtagagatatc 720 aagttaactaagatcccaatggaagttcttcacaaggtacctactactttgttacattct 780 ttggaaggaatgcctgatttggagtgggaaaaactgttaaagctacaatgtaaagatggt 840 agtttcttgttttccccatctagtaccgcattcgccctaatgcaaacaaaagatgagaaa 900 tgcttacagtatctaacaaatatcgtcactaagttcaacggtggcgtgcctaatgtgtac 960 ccagtcgatttgtttgaacatatttgggttgttgatagactgcagagattggggattgcc 1020 agatacttcaaatcagagataaaagattgtgtagagtatatcaataagtactggaccaaa 1080 aatggaatttgttgggctagaaatactcacgttcaagatatcgatgatacagccatggga 1140 ttcagagtgttgagagcgcacggttatgacgtcactccagatgtttttagacaatttgaa 1200 aaagatggtaaattcgtttgctttgcagggcaatcaacacaagccgtgacaggaatgttt 1260 aacgtttacagagcctctcaaatgttgttcccaggggagagaattttggaagatgccaaa 1320 aagttctcttacaattacttaaaggaaaagcaaagtaccaacgaattgctggataaatgg 1380 ataatcgctaaagatctacctggtgaagttggttatgctctggatatcccatggtatgct 1440 tccttaccaagattggaaactcgttattaccttgaacaatacggcggtgaagatgatgtc 1500 tggataggcaagacattatacagaatgggttacgtgtccaataacacatatctagaaatg 1560 gcaaagctggattacaataactatgttgcagtccttcaattagaatggtacacaatacaa 1620 caatggtacgtcgatattggtatagagaagttcgaatctgacaacatcaagtcagtcctg 1680 gtttcttactacttggctgcggcttcaatattcgaacctgagagatctaaggagagaatc 1740 gcttgggcaaagacaacaatcttagtcgataagatcacatcaattttcgattcctctcag 1800 tcaagtaaggaagatattactgcctttattgacaagtttcgtaacaagtcctcctctaaa 1860 aagcactctatcaacggtgaaccatggcatgaagttatggtagctttgaaaaagacctta 1920 cacggctttgctctggatgctcttatgactcattctcaagatatacatccacagttacat 1980 caagcctgggaaatgtggttgactaaactacaagacggcgtagatgttactgctgagcta 2040 atggtccaaatgatcaacatgactgctggcagatgggtatcaaaggaattacttactcat 2100 ccacaatatcaaagattgtctactgtgacaaattctgtgtgtcacgatattaccaaactt 2160 cacaatttcaaggagaattccaccacagtggattcaaaggttcaggaactagtccagttg 2220 gtttttagtgacacaccagatgatttggatcaagatatgaaacaaacattcctgacagtg 2280 atgaagacattctactacaaggcgtggtgtgatccaaacactataaacgatcatatatct 2340 aaagttttcgaaatcgtaatttga 2364 SEQIDNO:222 MKTGFISPATVFHHRISPATTFRHHLSPATTNSTGIVALRDINFRCKAVSKEYSDLLQKD 60 EASFTKWDDDKVKDHLDTNKNLYPNDEIKEFVESVKAMFGSMNDGEINVSAYDTAWVALV 120 QDVDGSGSPQFPSSLEWIANNQLSDGSWGDHLLFSAHDRIINTLACVIALTSWNVHPSKC 180 EKGLNFLRENICKLEDENAEHMPIGFEVTFPSLIDIAKKLNIEVPEDTPALKEIYARRDI 240 KLTKIPMEVLHKVPTTLLHSLEGMPDLEWEKLLKLQCKDGSFLFSPSSTAFALMQTKDEK 300 CLQYLTNIVTKFNGGVPNVYPVDLFEHIWVVDRLQRLGIARYFKSEIKDCVEYINKYWTK 360 NGICWARNTHVQDIDDTAMGFRVLRAHGYDVTPDVFRQFEKDGKFVCFAGQSTQAVTGMF 420 NVYRASQMLFPGERILEDAKKFSYNYLKEKQSTNELLDKWIIAKDLPGEVGYALDIPWYA 480 SLPRLETRYYLEQYGGEDDVWIGKTLYRMGYVSNNTYLEMAKLDYNNYVAVLQLEWYTIQ 540 QWYVDIGIEKFESDNIKSVLVSYYLAAASIFEPERSKERIAWAKTTILVDKITSIFDSSQ 600 SSKEDITAFIDKFRNKSSSKKHSINGEPWHEVMVALKKTLHGFALDALMTHSQDIHPQLH 660 QAWEMWLTKLQDGVDVTAELMVQMINMTAGRWVSKELLTHPQYQRLSTVTNSVCHDITKL 720 HNFKENSTTVDSKVQELVQLVFSDTPDDLDQDMKQTFLTVMKTFYYKAWCDPNTINDHIS 780 KVFEIVI 787 SEQIDNO:223 atgcctgatgcacacgatgctccacctccacaaataagacagagaacactagtagatgag 60 gctacccaactgctaactgagtccgcagaagatgcatggggtgaagtcagtgtgtcagaa 120 tacgaaacagcaaggctagttgcccatgctacatggttaggtggacacgccacaagagtg 180 gccttccttctggagagacaacacgaagacgggtcatggggtccaccaggtggatatagg 240 ttagtccctacattatctgctgttcacgcattattgacatgtcttgcctctcctgctcag 300 gatcatggcgttccacatgatagacttttaagagctgttgacgcaggcttgactgccttg 360 agaagattggggacatctgactccccacctgatactatagcagttgagctggttatccca 420 tctttgctagagggcattcaacacttactggaccctgctcatcctcatagtagaccagcc 480 ttctctcaacatagaggctctcttgtttgtcctggtggactagatgggagaactctagga 540 gctttgagatcacacgccgcagcaggtacaccagtaccaggaaaagtctggcacgcttcc 600 gagactttgggcttgagtaccgaagctgcttctcacttgcaaccagcccaaggtataatc 660 ggtggctctgctgctgccacagcaacatggctaaccagggttgcaccatctcaacagtca 720 gattctgccagaagataccttgaggaattacaacacagatactctggcccagttccttcc 780 attacccctatcacatacttcgaaagagcatggttattgaacaattttgcagcagccggt 840 gttccttgtgaggctccagctgctttgttggattccttagaagcagcacttacaccacaa 900 ggtgctcctgctggagcaggattgcctccagatgctgatgatacagccgctgtgttgctt 960 gcattggcaacacatgggagaggtagaagaccagaagtactgatggattacaggactgac 1020 gggtatttccaatgctttattggggaaaggactccatcaatttcaacaaacgctcacgta 1080 ttggaaacattagggcatcatgtggcccaacatccacaagatagagccagatacggatca 1140 gccatggataccgcatcagcttggctgctggcagctcaaaagcaagatggctcttggtta 1200 gataaatggcatgcctcaccatactacgctactgtttgttgcacacaagccctagccgct 1260 catgcaagtcctgcaactgcaccagctagacagagagctgtcagatgggttttagccaca 1320 caaagatccgatggcggttggggtctatggcattcaactgttgaagagactgcttatgcc 1380 ttacagatcttggccccaccttctggtggtggcaatatcccagtccaacaagcacttact 1440 agaggcagagcaagattgtgtggagccttgccactgactcctttatggcatgataaggat 1500 ttgtatactccagtaagagtagtcagagctgccagagctgctgctctgtacactaccaga 1560 gatctattgttaccaccattgtaa 1584 SEQIDNO:224 MPDAHDAPPPQIRQRTLVDEATQLLTESAEDAWGEVSVSEYETARLVAHATWLGGHATRV 60 AFLLERQHEDGSWGPPGGYRLVPTLSAVHALLTCLASPAQDHGVPHDRLLRAVDAGLTAL 120 RRLGTSDSPPDTIAVELVIPSLLEGIQHLLDPAHPHSRPAFSQHRGSLVCPGGLDGRTLG 180 ALRSHAAAGTPVPGKVWHASETLGLSTEAASHLQPAQGIIGGSAAATATWLTRVAPSQQS 240 DSARRYLEELQHRYSGPVPSITPITYFERAWLLNNFAAAGVPCEAPAALLDSLEAALTPQ 300 GAPAGAGLPPDADDTAAVLLALATHGRGRRPEVLMDYRTDGYFQCFIGERTPSISTNAHV 360 LETLGHHVAQHPQDRARYGSAMDTASAWLLAAQKQDGSWLDKWHASPYYATVCCTQALAA 420 HASPATAPARQRAVRWVLATQRSDGGWGLWHSTVEETAYALQILAPPSGGGNIPVQQALT 480 RGRARLCGALPLTPLWHDKDLYTPVRVVRAARAAALYTTRDLLLPPL 527 SEQIDNO:225 atgaacgccctatccgaacacattttgtctgaattgagaagattattgtctgaaatgagt 60 gatggcggatctgttggtccatctgtgtatgatacggcccaggccctaagattccacggt 120 aacgtaacaggtagacaagatgcatatgcttggttgatcgcccagcaacaagcagatgga 180 ggttggggctctgccgactttccactctttagacatgctccaacatgggctgcacttctc 240 gcattacaaagagctgatccacttcctggcgcagcagacgcagttcagaccgcaacaaga 300 ttcttgcaaagacaaccagatccatacgctcatgccgttcctgaggatgcccctattggt 360 gctgaactgatcttgcctcagttttgtggagaggctgcttggttgttgggaggtgtggcc 420 ttccctagacacccagccctattaccattaagacaggcttgtttagtcaaactgggtgca 480 gtcgccatgttgccttcaggacacccattgctccactcctgggaggcatggggtacttct 540 ccaacaacagcctgtccagacgatgatggttctataggtatctcaccagcagctacagcc 600 gcctggagagcccaggctgtgaccagaggctcaactcctcaagtgggcagagctgacgca 660 tacttacaaatggcttcaagagcaacgagatcaggcatagaaggagtcttccctaatgtt 720 tggcctataaacgtattcgaaccatgctggtcactgtacactctccatcttgccggtctg 780 ttcgcccatccagcactggctgaggctgtaagagttatcgttgctcaacttgaagcaaga 840 ttgggagtgcatggcctcggaccagctttacattttgctgccgacgctgatgatactgca 900 gttgccttatgcgttctgcatttggctggcagagatcctgcagttgacgcattgagacat 960 tttgaaattggtgagctctttgttacattcccaggagagagaaatgctagtgtctctacg 1020 aacattcacgctcttcatgctttgagattgttaggtaaaccagctgccggagcaagtgca 1080 tacgtcgaagcaaatagaaatccacatggtttgtgggacaacgaaaaatggcacgtttca 1140 tggctttatccaactgcacacgccgttgcagctctagctcaaggcaagcctcaatggaga 1200 gatgaaagagcactagccgctctactacaagctcaaagagatgatggtggttggggagct 1260 ggtagaggatccactttcgaggaaaccgcctacgctcttttcgctttacacgttatggac 1320 ggatctgaggaagccacaggcagaagaagaatcgctcaagtcgtcgcaagagccttagaa 1380 tggatgctagctagacatgccgcacatggattaccacaaacaccactctggattggtaag 1440 gaattgtactgtcctactagagtcgtaagagtagctgagctagctggcctgtggttagca 1500 ttaagatggggtagaagagtattagctgaaggtgctggtgctgcaccttaa 1551 SEQIDNO:226 MNALSEHILSELRRLLSEMSDGGSVGPSVYDTAQALRFHGNVTGRQDAYAWLIAQQQADG 60 GWGSADFPLFRHAPTWAALLALQRADPLPGAADAVQTATRFLQRQPDPYAHAVPEDAPIG 120 AELILPQFCGEAAWLLGGVAFPRHPALLPLRQACLVKLGAVAMLPSGHPLLHSWEAWGTS 180 PTTACPDDDGSIGISPAATAAWRAQAVTRGSTPQVGRADAYLQMASRATRSGIEGVFPNV 240 WPINVFEPCWSLYTLHLAGLFAHPALAEAVRVIVAQLEARLGVHGLGPALHFAADADDTA 300 VALCVLHLAGRDPAVDALRHFEIGELFVTFPGERNASVSTNIHALHALRLLGKPAAGASA 360 YVEANRNPHGLWDNEKWHVSWLYPTAHAVAALAQGKPQWRDERALAALLQAQRDDGGWGA 420 GRGSTFEETAYALFALHVMDGSEEATGRRRIAQVVARALEWMLARHAAHGLPQTPLWIGK 480 ELYCPTRVVRVAELAGLWLALRWGRRVLAEGAGAAP 516 SEQIDNO:227 atggttttgtcttcttcttgtactacagtaccacacttatcttcattagctgtcgtgcaa 60 cttggtccttggagcagtaggattaaaaagaaaaccgatactgttgcagtaccagccgct 120 gcaggaaggtggagaagggccttggctagagcacagcacacatcagaatccgcagctgtc 180 gcaaagggcagcagtttgacccctatagtgagaactgacgctgagtcaaggagaacaaga 240 tggccaaccgatgacgatgacgccgaacctttagtggatgagatcagggcaatgcttact 300 tccatgtctgatggtgacatttccgtgagcgcatacgatacagcctgggtcggattggtt 360 ccaagattagacggcggtgaaggtcctcaatttccagcagctgtgagatggataagaaat 420 aaccagttgcctgacggaagttggggcgatgccgcattattctctgcctatgacaggctt 480 atcaatacccttgcctgcgttgtaactttgacaaggtggtccctagaaccagagatgaga 540 ggtagaggactatcttttttgggtaggaacatgtggaaattagcaactgaagatgaagag 600 tcaatgcctattggcttcgaattagcatttccatctttgatagagcttgctaagagccta 660 ggtgtccatgacttcccttatgatcaccaggccctacaaggaatctactcttcaagagag 720 atcaaaatgaagaggattccaaaagaagtgatgcataccgttccaacatcaatattgcac 780 agtttggagggtatgcctggcctagattgggctaaactacttaaactacagagcagcgac 840 ggaagttttttgttctcaccagctgccactgcatatgctttaatgaataccggagatgac 900 aggtgttttagctacatcgatagaacagtaaagaaattcaacggcggcgtccctaatgtt 960 tatccagtggatctatttgaacatatttgggccgttgatagacttgaaagattaggaatc 1020 tccaggtacttccaaaaggagatcgaacaatgcatggattatgtaaacaggcattggact 1080 gaggacggtatttgttgggcaaggaactctgatgtcaaagaggtggacgacacagctatg 1140 gcctttagacttcttaggttgcacggctacagcgtcagtcctgatgtgtttaaaaacttc 1200 gaaaaggacggtgaatttttcgcatttgtcggacagtctaatcaagctgttaccggtatg 1260 tacaacttaaacagagcaagccagatatccttcccaggcgaggatgtgcttcatagagct 1320 ggtgccttctcatatgagttcttgaggagaaaagaagcagagggagctttgagggacaag 1380 tggatcatttctaaagatctacctggtgaagttgtgtatactttggattttccatggtac 1440 ggcaacttacctagagtcgaggccagagactacctagagcaatacggaggtggtgatgac 1500 gtttggattggcaagacattgtataggatgccacttgtaaacaatgatgtatatttggaa 1560 ttggcaagaatggatttcaaccactgccaggctttgcatcagttagagtggcaaggacta 1620 aaaagatggtatactgaaaataggttgatggactttggtgtcgcccaagaagatgccctt 1680 agagcttattttcttgcagccgcatctgtttacgagccttgtagagctgccgagaggctt 1740 gcatgggctagagccgcaatactagctaacgccgtgagcacccacttaagaaatagccca 1800 tcattcagagaaaggttagagcattctcttaggtgtagacctagtgaagagacagatggc 1860 tcctggtttaactcctcaagtggctctgatgcagttttagtaaaggctgtcttaagactt 1920 actgattcattagccagggaagcacagccaatccatggaggtgacccagaagatattata 1980 cacaagttgttaagatctgcttgggccgagtgggttagggaaaaggcagacgctgccgat 2040 agcgtgtgcaatggtagttctgcagtagaacaagagggatcaagaatggtccatgataaa 2100 cagacctgtctattattggctagaatgatcgaaatttctgccggtagggcagctggtgaa 2160 gcagccagtgaggacggcgatagaagaataattcaattaacaggctccatctgcgacagt 2220 cttaagcaaaaaatgctagtttcacaggaccctgaaaaaaatgaagagatgatgtctcac 2280 gtggatgacgaattgaagttgaggattagagagttcgttcaatatttgcttagactaggt 2340 gaaaaaaagactggatctagcgaaaccaggcaaacatttttaagtatagtgaaatcatgt 2400 tactatgctgctcattgcccacctcatgtcgttgatagacacattagtagagtgattttc 2460 gagccagtaagtgccgcaaagtaaccgcgg 2490 SEQIDNO:228 MVLSSSCTTVPHLSSLAVVQLGPWSSRIKKKTDTVAVPAAAGRWRRALARAQHTSESAAV 60 AKGSSLTPIVRTDAESRRTRWPTDDDDAEPLVDEIRAMLTSMSDGDISVSAYDTAWVGLV 120 PRLDGGEGPQFPAAVRWIRNNQLPDGSWGDAALFSAYDRLINTLACVVTLTRWSLEPEMR 180 GRGLSFLGRNMWKLATEDEESMPIGFELAFPSLIELAKSLGVHDFPYDHQALQGIYSSRE 240 IKMKRIPKEVMHTVPTSILHSLEGMPGLDWAKLLKLQSSDGSFLFSPAATAYALMNTGDD 300 RCFSYIDRTVKKFNGGVPNVYPVDLFEHIWAVDRLERLGISRYFQKEIEQCMDYVNRHWT 360 EDGICWARNSDVKEVDDTAMAFRLLRLHGYSVSPDVFKNFEKDGEFFAFVGQSNQAVTGM 420 YNLNRASQISFPGEDVLHRAGAFSYEFLRRKEAEGALRDKWIISKDLPGEVVYTLDFPWY 480 GNLPRVEARDYLEQYGGGDDVWIGKTLYRMPLVNNDVYLELARMDFNHCQALHQLEWQGL 540 KRWYTENRLMDFGVAQEDALRAYFLAAASVYEPCRAAERLAWARAAILANAVSTHLRNSP 600 SFRERLEHSLRCRPSEETDGSWFNSSSGSDAVLVKAVLRLTDSLAREAQPIHGGDPEDII 660 HKLLRSAWAEWVREKADAADSVCNGSSAVEQEGSRMVHDKQTCLLLARMIEISAGRAAGE 720 AASEDGDRRIIQLTGSICDSLKQKMLVSQDPEKNEEMMSHVDDELKLRIREFVQYLLRLG 780 EKKTGSSETRQTFLSIVKSCYYAAHCPPHVVDRHISRVIFEPVSAAK 827 SEQIDNO:229 cttcttcactaaatacttagacagagaaaacagagctttttaaagccatgtctcttcagt 60 atcatgttctaaactccattccaagtacaacctttctcagttctactaaaacaacaatat 120 cttcttctttccttaccatctcaggatctcctctcaatgtcgctagagacaaatccagaa 180 gcggttccatacattgttcaaagcttcgaactcaagaatacattaattctcaagaggttc 240 aacatgatttgcctctaatacatgagtggcaacagcttcaaggagaagatgctcctcaga 300 ttagtgttggaagtaatagtaatgcattcaaagaagcagtgaagagtgtgaaaacgatct 360 tgagaaacctaacggacggggaaattacgatatcggcttacgatacagcttgggttgcat 420 tgatcgatgccggagataaaactccggcgtttccctccgccgtgaaatggatcgccgaga 480 accaactttccgatggttcttggggagatgcgtatctcttctcttatcatgatcgtctca 540 tcaatacccttgcatgcgtcgttgctctaagatcatggaatctctttcctcatcaatgca 600 acaaaggaatcacgtttttccgggaaaatattgggaagctagaagacgaaaatgatgagc 660 atatgccaatcggattcgaagtagcattcccatcgttgcttgagatagctcgaggaataa 720 acattgatgtaccgtacgattctccggtcttaaaagatatatacgccaagaaagagctaa 780 agcttacaaggataccaaaagagataatgcacaagataccaacaacattgttgcatagtt 840 tggaggggatgcgtgatttagattgggaaaagctcttgaaacttcaatctcaagacggat 900 ctttcctcttctctccttcctctaccgcttttgcattcatgcagacccgagacagtaact 960 gcctcgagtatttgcgaaatgccgtcaaacgtttcaatggaggagttcccaatgtctttc 1020 ccgtggatcttttcgagcacatatggatagtggatcggttacaacgtttagggatatcga 1080 gatactttgaagaagagattaaagagtgtcttgactatgtccacagatattggaccgaca 1140 atggcatatgttgggctagatgttcccatgtccaagacatcgatgatacagccatggcat 1200 ttaggctcttaagacaacatggataccaagtgtccgcagatgtattcaagaactttgaga 1260 aagagggagagtttttctgctttgtggggcaatcaaaccaagcagtaaccggtatgttca 1320 acctataccgggcatcacaattggcgtttccaagggaagagatattgaaaaacgccaaag 1380 agttttcttataattatctgctagaaaaacgggagagagaggagttgattgataagtgga 1440 ttataatgaaagacttacctggcgagattgggtttgcgttagagattccatggtacgcaa 1500 gcttgcctcgagtagagacgagattctatattgatcaatatggtggagaaaacgacgttt 1560 ggattggcaagactctttataggatgccatacgtgaacaataatggatatctggaattag 1620 caaaacaagattacaacaattgccaagctcagcatcagctcgaatgggacatattccaaa 1680 agtggtatgaagaaaataggttaagtgagtggggtgtgcgcagaagtgagcttctcgagt 1740 gttactacttagcggctgcaactatatttgaatcagaaaggtcacatgagagaatggttt 1800 gggctaagtcaagtgtattggttaaagccatttcttcttcttttggggaatcctctgact 1860 ccagaagaagcttctccgatcagtttcatgaatacattgccaatgctcgacgaagtgatc 1920 atcactttaatgacaggaacatgagattggaccgaccaggatcggttcaggccagtcggc 1980 ttgccggagtgttaatcgggactttgaatcaaatgtcttttgaccttttcatgtctcatg 2040 gccgtgacgttaacaatctcctctatctatcgtggggagattggatggaaaaatggaaac 2100 tatatggagatgaaggagaaggagagctcatggtgaagatgataattctaatgaagaaca 2160 atgacctaactaacttcttcacccacactcacttcgttcgtctcgcggaaatcatcaatc 2220 gaatctgtcttcctcgccaatacttaaaggcaaggagaaacgatgagaaggagaagacaa 2280 taaagagtatggagaaggagatggggaaaatggttgagttagcattgtcggagagtgaca 2340 catttcgtgacgtcagcatcacgtttcttgatgtagcaaaagcattttactactttgctt 2400 tatgtggcgatcatctccaaactcacatctccaaagtcttgtttcaaaaagtctagtaac 2460 ctcatcatcatcatcgatccattaacaatcagtggatcgatgtatccatagatgcgtgaa 2520 taatatttcatgtagagaaggagaacaaattagatcatgtagggttatca 2570 SEQIDNO:230 MSLQYHVLNSIPSTTFLSSTKTTISSSFLTISGSPLNVARDKSRSGSIHCSKLRTQEYIN 60 SQEVQHDLPLIHEWQQLQGEDAPQISVGSNSNAFKEAVKSVKTILRNLTDGEITISAYDT 120 AWVALIDAGDKTPAFPSAVKWIAENQLSDGSWGDAYLFSYHDRLINTLACVVALRSWNLF 180 PHQCNKGITFFRENIGKLEDENDEHMPIGFEVAFPSLLEIARGINIDVPYDSPVLKDIYA 240 KKELKLTRIPKEIMHKIPTTLLHSLEGMRDLDWEKLLKLQSQDGSFLFSPSSTAFAFMQT 300 RDSNCLEYLRNAVKRFNGGVPNVFPVDLFEHIWIVDRLQRLGISRYFEEEIKECLDYVHR 360 YWTDNGICWARCSHVQDIDDTAMAFRLLRQHGYQVSADVFKNFEKEGEFFCFVGQSNQAV 420 TGMFNLYRASQLAFPREEILKNAKEFSYNYLLEKREREELIDKWIIMKDLPGEIGFALEI 480 PWYASLPRVETRFYIDQYGGENDVWIGKTLYRMPYVNNNGYLELAKQDYNNCQAQHQLEW 540 DIFQKWYEENRLSEWGVRRSELLECYYLAAATIFESERSHERMVWAKSSVLVKAISSSFG 600 ESSDSRRSFSDQFHEYIANARRSDHHFNDRNMRLDRPGSVQASRLAGVLIGTLNQMSFDL 660 FMSHGRDVNNLLYLSWGDWMEKWKLYGDEGEGELMVKMIILMKNNDLTNFFTHTHFVRLA 720 EIINRICLPRQYLKARRNDEKEKTIKSMEKEMGKMVELALSESDTFRDVSITFLDVAKAF 780 YYFALCGDHLQTHISKVLFQKV 802 SEQIDNO:231 atgaatttgagtttgtgtatagcatctccactattgaccaaatctaatagaccagctgct 60 ttatcagcaattcatacagctagtacatcccatggtggccaaaccaaccctacgaatctg 120 ataatcgatacgaccaaggagagaatacaaaaacaattcaaaaatgttgaaatttcagtt 180 tcttcttatgatactgcgtgggttgccatggttccatcacctaattctccaaagtctcca 240 tgtttcccagaatgtttgaattggctgattaacaaccagttgaatgatggatcttggggt 300 ttagtcaatcacacgcacaatcacaaccatccacttttgaaagattctttatcctcaact 360 ttggcttgcatcgtggccctaaagagatggaacgtaggtgaggatcagattaacaagggg 420 cttagtttcattgaatctaacttggcttccgcgactgaaaaatctcaaccatctccaata 480 ggattcgatatcatctttccaggtctgttagagtacgccaaaaatctagatatcaactta 540 ctgtctaagcaaactgatttctcactaatgttacacaagagagaattagaacaaaagaga 600 tgtcattcaaacgaaatggatggttacctagcttatatctctgaaggtcttggtaatctt 660 tacgattggaatatggtgaaaaagtaccagatgaaaaatggctcagttttcaattcccct 720 tctgcaactgcggcagcattcattaaccatcaaaatccaggatgcctgaactatttgaat 780 tcactactagacaaattcggcaacgcagttccaactgtataccctcacgatttgtttatc 840 agattgagtatggtggatacaattgaaagacttggtatatcccaccactttagagtcgag 900 atcaaaaatgttttggatgagacataccgttgttgggtggagagagatgaacaaatcttt 960 atggatgttgtgacgtgcgcgttggcctttagattgttgcgtattaacggttacgaagtt 1020 agtccagatccacttgccgaaattacaaacgaattagctttaaaggatgaatacgccgct 1080 cttgaaacatatcatgcgtcacatatcctttaccaagaggacttatcatctggaaaacaa 1140 attcttaaatctgctgatttcctgaaggaaatcatatccactgatagtaatagactgtcc 1200 aaactgatccataaagaggttgaaaatgcacttaagttccctattaacaccggcttagaa 1260 cgtattaacacaagacgtaacatccagctttacaacgtagacaatactagaatcttgaaa 1320 accacttaccattcttccaacatatcaaacactgattacctaagattagctgttgaagat 1380 ttctacacatgtcagtctatctatagagaagagctgaaaggattagagagatgggtcgtt 1440 gagaataagctagatcaattgaaatttgccagacaaaagacagcttattgttacttctca 1500 gttgccgccactttatcaagtccagaattgtcagatgcacgtatttcttgggctaaaaac 1560 ggaattttgacaactgttgttgatgatttctttgatattggcgggacaatcgacgaattg 1620 acaaacctgattcaatgcgttgaaaagtggaatgtcgatgtcgataaagactgttgctca 1680 gaacatgttagaatactgttcttggctctgaaagatgctatctgttggatcggggatgag 1740 gctttcaaatggcaagctagagatgtgacgtctcacgtcattcaaacctggctagaactg 1800 atgaactctatgttgagagaagcaatttggactagagatgcatacgttcctacattaaac 1860 gagtatatggaaaacgcttatgtctcctttgctttgggtcctatcgttaagcctgccata 1920 tactttgtaggaccaaagctatccgaggaaatcgtcgaatcatcagaataccataacttg 1980 ttcaagttaatgtccacacaaggcagattacttaatgatattcattctttcaaaagagag 2040 tttaaggaaggaaagttaaatgctgttgctctgcatctttctaatggcgaaagtggtaaa 2100 gtcgaagaggaagtagttgaggaaatgatgatgatgatcaaaaacaagagaaaggagttg 2160 atgaaactaatcttcgaagagaacggttcaattgttcctagagcatgtaaggatgcattt 2220 tggaacatgtgtcatgtgctaaactttttctacgcaaacgacgatggttttactgggaac 2280 acaatactagatacagtaaaagacatcatatacaaccctttggtcttagtaaacgaaaac 2340 gaggagcaaagataa 2355 SEQIDNO:232 MNLSLCIASPLLTKSNRPAALSAIHTASTSHGGQTNPTNLIIDTTKERIQKQFKNVEISV 60 SSYDTAWVAMVPSPNSPKSPCFPECLNWLINNQLNDGSWGLVNHTHNHNHPLLKDSLSST 120 LACIVALKRWNVGEDQINKGLSFIESNLASATEKSQPSPIGFDIIFPGLLEYAKNLDINL 180 LSKQTDFSLMLHKRELEQKRCHSNEMDGYLAYISEGLGNLYDWNMVKKYQMKNGSVFNSP 240 SATAAAFINHQNPGCLNYLNSLLDKFGNAVPTVYPHDLFIRLSMVDTIERLGISHHFRVE 300 IKNVLDETYRCWVERDEQIFMDVVTCALAFRLLRINGYEVSPDPLAEITNELALKDEYAA 360 LETYHASHILYQEDLSSGKQILKSADFLKEIISTDSNRLSKLIHKEVENALKFPINTGLE 420 RINTRRNIQLYNVDNTRILKTTYHSSNISNTDYLRLAVEDFYTCQSIYREELKGLERWVV 480 ENKLDQLKFARQKTAYCYFSVAATLSSPELSDARISWAKNGILTTVVDDFFDIGGTIDEL 540 TNLIQCVEKWNVDVDKDCCSEHVRILFLALKDAICWIGDEAFKWQARDVTSHVIQTWLEL 600 MNSMLREAIWTRDAYVPTLNEYMENAYVSFALGPIVKPAIYFVGPKLSEEIVESSEYHNL 660 FKLMSTQGRLLNDIHSFKREFKEGKLNAVALHLSNGESGKVEEEVVEEMMMMIKNKRKEL 720 MKLIFEENGSIVPRACKDAFWNMCHVLNFFYANDDGFTGNTILDTVKDIIYNPLVLVNEN 780 EEQR 784 SEQIDNO:233 atgaatctgtccctttgtatagctagtccactgttgacaaaatcttctagaccaactgct 60 ctttctgcaattcatactgccagtactagtcatggaggtcaaacaaacccaacaaatttg 120 ataatcgatactactaaggagagaatccaaaagctattcaaaaatgttgaaatctcagta 180 tcatcttatgacaccgcatgggttgcaatggtgccatcacctaattccccaaaaagtcca 240 tgttttccagagtgcttgaattggttaatcaataatcagttaaacgatggttcttggggt 300 ttagtcaaccacactcataaccacaatcatccattattgaaggactctttatcatcaaca 360 ttagcctgtattgttgcattgaaaagatggaatgtaggtgaagatcaaatcaacaagggt 420 ttatcattcatagaatccaatctagcttctgctaccgacaaatcacaaccatctccaatc 480 gggttcgacataatcttccctggtttgctggagtatgccaaaaaccttgatatcaactta 540 ctgtctaaacaaacagatttctctttgatgctacacaaaagagagttagagcagaaaaga 600 tgccattctaacgaaattgacgggtacttagcatatatctcagaaggtttgggtaatttg 660 tatgactggaacatggtcaaaaagtatcagatgaaaaatggatccgtattcaattctcct 720 tctgcaactgccgcagcattcattaatcatcaaaaccctgggtgtcttaactacttgaac 780 tcactattagataagtttggaaatgcagttccaacagtctatcctttggacttgtacatc 840 agattatctatggttgacactatagagagattaggtatttctcatcatttcagagttgag 900 atcaaaaatgttttggacgagacatacagatgttgggtcgaaagagatgagcaaatcttt 960 atggatgtcgtgacctgcgctctggcttttagattgctaaggatacacggatacaaagta 1020 tctcctgatcaactggctgagattacaaacgaactggctttcaaagacgaatacgccgca 1080 ttagaaacataccatgcatcccaaatactttaccaggaagacctaagttcaggaaaacaa 1140 atcttgaagtctgcagatttcctgaaaggcattctgtctacagatagtaataggttgtct 1200 aaattgatacacaaggaagtagaaaacgcactaaagtttcctattaacactggtttagag 1260 agaatcaatactaggagaaacattcagctgtacaacgtagataatacaaggattcttaag 1320 accacctaccatagttcaaacatttccaacacctattacttaagattagctgtcgaagac 1380 ttttacacttgtcaatcaatctacagagaggagttaaagggcctagaaagatgggtagtt 1440 caaaacaagttggatcaactgaagtttgctagacagaagacagcatactgttatttctct 1500 gttgctgctaccctttcatccccagaattgtctgatgccagaataagttgggccaaaaat 1560 ggtattcttacaactgtagtcgatgatttctttgatattggaggtactattgatgaactg 1620 acaaatcttattcaatgtgttgaaaagtggaacgtggatgtagataaggattgctgcagt 1680 gaacatgtgagaatacttttcctggctctaaaagatgcaatatgttggattggcgacgag 1740 gccttcaagtggcaagctagagatgttacatctcatgtcatccaaacttggcttgaactg 1800 atgaactcaatgctaagagaagcaatctggacaagagatgcatacgttccaacattgaac 1860 gaatacatggaaaacgcttacgtctcatttgccttgggtcctattgttaagccagccata 1920 tactttgttgggccaaagttatccgaagagattgttgagtcttccgaatatcataaccta 1980 ttcaagttaatgtcaacacaaggcagacttctgaacgatatccactccttcaaaagagaa 2040 ttcaaggaaggtaagctaaacgctgttgctttgcacttgtctaatggtgaatctggcaaa 2100 gtggaagaggaagtcgttgaggaaatgatgatgatgatcaaaaacaagagaaaggaattg 2160 atgaaattgattttcgaggaaaatggttcaatcgtacctagagcttgtaaagatgctttt 2220 tggaatatgtgccatgttcttaacttcttttacgctaatgatgatggcttcactggaaat 2280 acaatattggatacagttaaagatatcatctacaacccacttgttttggtcaatgagaac 2340 gaggaacaaagataa 2355 SEQIDNO:234 MNLSLCIASPLLTKSSRPTALSAIHTASTSHGGQTNPTNLIIDTTKERIQKLFKNVEISV 60 SSYDTAWVAMVPSPNSPKSPCFPECLNWLINNQLNDGSWGLVNHTHNHNHPLLKDSLSST 120 LACIVALKRWNVGEDQINKGLSFIESNLASATDKSQPSPIGFDIIFPGLLEYAKNLDINL 180 LSKQTDFSLMLHKRELEQKRCHSNEIDGYLAYISEGLGNLYDWNMVKKYQMKNGSVFNSP 240 SATAAAFINHQNPGCLNYLNSLLDKFGNAVPTVYPLDLYIRLSMVDTIERLGISHHFRVE 300 IKNVLDETYRCWVERDEQIFMDVVTCALAFRLLRIHGYKVSPDQLAEITNELAFKDEYAA 360 LETYHASQILYQEDLSSGKQILKSADFLKGILSTDSNRLSKLIHKEVENALKFPINTGLE 420 RINTRRNIQLYNVDNTRILKTTYHSSNISNTYYLRLAVEDFYTCQSIYREELKGLERWVV 480 QNKLDQLKFARQKTAYCYFSVAATLSSPELSDARISWAKNGILTTVVDDFFDIGGTIDEL 540 TNLIQCVEKWNVDVDKDCCSEHVRILFLALKDAICWIGDEAFKWQARDVTSHVIQTWLEL 600 MNSMLREAIWTRDAYVPTLNEYMENAYVSFALGPIVKPAIYFVGPKLSEEIVESSEYHNL 660 FKLMSTQGRLLNDIHSFKREFKEGKLNAVALHLSNGESGKVEEEVVEEMMMMIKNKRKEL 720 MKLIFEENGSIVPRACKDAFWNMCHVLNFFYANDDGFTGNTILDTVKDIIYNPLVLVNEN 780 EEQR 784 SEQIDNO:235 atggctatgccagtgaagctaacacctgcgtcattatccttaaaagctgtgtgctgcaga 60 ttctcatccggtggccatgctttgagattcgggagtagtctgccatgttggagaaggacc 120 cctacccaaagatctacttcttcctctactactagaccagctgccgaagtgtcatcaggt 180 aagagtaaacaacatgatcaggaagctagtgaagcgactatcagacaacaattacaactt 240 gtggatgtcctggagaatatgggaatatccagacattttgctgcagagataaagtgcata 300 ctagacagaacttacagatcttggttacaaagacacgaggaaatcatgctggacactatg 360 acatgtgctatggcttttagaatcctaagattgaacggatacaacgtttcatcagatgaa 420 ctataccacgttgtagaggcatctggtctgcataattctttgggtgggtatcttaacgat 480 accagaacactacttgaattacacaaggcttcaacagttagtatctctgaggatgaatct 540 atcttagattcaattggctctagatccagaacattgcttagagaacaattggagtctggt 600 ggcgcactgagaaagccttctttattcaaagaggttgaacatgcactggatggacctttt 660 tacaccacacttgatagacttcatcataggtggaatattgaaaacttcaacattattgag 720 caacacatgttggagactccatacttatctaaccagcatacatcaagggatatcctagca 780 ttgtcaattagagatttttcctcctcacaattcacttatcaacaagagctacagcatctg 840 gagagttgggttaaggaatgtagattagatcaactacagttcgcaagacagaaattagcg 900 tacttttacctatcagccgcaggcaccatgttttctcctgagctttctgatgcgagaaca 960 ttatgggccaaaaacggggtgttgacaactattgttgatgatttctttgatgttgccggt 1020 tctaaagaggaattggaaaacttagtcatgctggtcgaaatgtgggatgaacatcacaaa 1080 gttgaattctattctgagcaggtcgaaatcatcttctcttccatctacgattctgtcaac 1140 caattgggtgagaaggcctctttggttcaagacagatcaattacaaaacaccttgttgaa 1200 atatggttagacttgttaaagtccatgatgacggaagttgaatggagactgtcaaaatac 1260 gtgcctacagaaaaggaatacatgattaatgcctctcttatcttcggcctaggtccaatc 1320 gttttaccagctttgtatttcgttggtccaaagatttcagaaagtatagtaaaggaccca 1380 gaatatgatgaattgttcaaactaatgtcaacatgtggtagattgttgaatgacgtgcaa 1440 acgttcgaaagagaatacaatgagggtaaactgaattctgtcagtctattggttcttcac 1500 ggaggcccaatgtctatttcagacgcaaagaggaaattacaaaagcctattgatacgtgt 1560 agaagagatcttctttctttggtccttagagaagagtctgtagtaccaagaccatgtaag 1620 gaactattctggaaaatgtgtaaagtgtgctatttcttttactcaacaactgatgggttt 1680 tctagtcaagtcgaaagagcaaaagaggtagacgctgtcataaatgagccactgaagttg 1740 caaggttctcatacactggtatctgatgtttaa 1773 SEQIDNO:236 MAMPVKLTPASLSLKAVCCRFSSGGHALRFGSSLPCWRRTPTQRSTSSSTTRPAAEVSSG 60 KSKQHDQEASEATIRQQLQLVDVLENMGISRHFAAEIKCILDRTYRSWLQRHEEIMLDTM 120 TCAMAFRILRLNGYNVSSDELYHVVEASGLHNSLGGYLNDTRTLLELHKASTVSISEDES 180 ILDSIGSRSRTLLREQLESGGALRKPSLFKEVEHALDGPFYTTLDRLHHRWNIENFNIIE 240 QHMLETPYLSNQHTSRDILALSIRDFSSSQFTYQQELQHLESWVKECRLDQLQFARQKLA 300 YFYLSAAGTMFSPELSDARTLWAKNGVLTTIVDDFFDVAGSKEELENLVMLVEMWDEHHK 360 VEFYSEQVEIIFSSIYDSVNQLGEKASLVQDRSITKHLVEIWLDLLKSMMTEVEWRLSKY 420 VPTEKEYMINASLIFGLGPIVLPALYFVGPKISESIVKDPEYDELFKLMSTCGRLLNDVQ 480 TFEREYNEGKLNSVSLLVLHGGPMSISDAKRKLQKPIDTCRRDLLSLVLREESVVPRPCK 540 ELFWKMCKVCYFFYSTTDGFSSQVERAKEVDAVINEPLKLQGSHTLVSDV 590 SEQIDNO:237 atgcagaacttccatggtacaaaggaaaggatcaaaaagatgtttgacaagattgaattg 60 tccgtttcttcttatgatacagcctgggttgcaatggtcccatcccctgattgcccagaa 120 acaccttgttttccagaatgtactaaatggatcctagaaaatcagttgggtgatggtagt 180 tggtcacttcctcatggcaatccacttctagttaaagatgcattatcttccactcttgct 240 tgtattctggctcttaaaagatggggaatcggtgaggaacagattaacaaaggactgaga 300 ttcatagaactcaactctgctagtgtaaccgataacgaacaacacaaaccaattggattt 360 gacattatctttccaggtatgattgaatacgctatagacttagacctgaatctaccacta 420 aaaccaactgacattaactccatgttgcatcgtagagcccttgaattgacatcaggtgga 480 ggcaaaaatctagaaggtagaagagcttacttggcctacgtctctgaaggaatcggtaag 540 ctgcaagattgggaaatggctatgaaataccaacgtaaaaacggatctctgttcaatagt 600 ccatcaacaactgcagctgcattcatccatatacaagatgctgaatgcctccactatatt 660 cgttctcttctccagaaatttggaaacgcagtccctacaatataccctctcgatatctat 720 gccagactttcaatggtagatgccctggaacgtcttggtattgatagacatttcagaaag 780 gagagaaagttcgttctggatgaaacatacagattttggttgcaaggagaagaggagatt 840 ttctccgataacgcaacctgtgctttggccttcagaatattgagacttaatggttacgat 900 gtctctcttgaagatcacttctctaactctctgggcggttacttaaaggactcaggagca 960 gctttagaactgtacagagccctccaattgtcttacccagacgagtccctcctggaaaag 1020 caaaattctagaacttcttacttcttaaaacaaggtttatccaatgtctccctctgtggt 1080 gacagattgcgtaaaaacataattggagaggtgcatgatgctttaaacttttccgaccac 1140 gctaacttacaaagattagctattcgtagaaggattaagcattacgctactgacgataca 1200 aggattctaaaaacttcctacagatgctcaacaatcggtaaccaagattttctaaaactt 1260 gcagtggaagatttcaatatctgtcaatcaatacaaagagaggaattcaagcatattgaa 1320 agatgggtcgttgaaagacgtctagacaagttaaagttcgctagacaaaaagaggcctat 1380 tgctatttctcagccgcagcaacattgtttgcccctgaattgtctgatgctagaatgtct 1440 tgggccaaaaatggtgtattgacaactgtggttgatgatttcttcgatgtcggaggctct 1500 gaagaggaattagttaacttgatagaattgatcgagcgttgggatgtgaatggcagtgca 1560 gatttttgtagtgaggaagttgagattatctattctgctatccactcaactatctctgaa 1620 ataggtgataagtcatttggctggcaaggtagagatgtaaagtctcaagttatcaagatc 1680 tggctggacttattgaaatcaatgttaactgaagctcaatggtcttcaaacaagtctgtt 1740 cctaccctagatgagtatatgacaaccgcccatgtttcattcgcacttggtccaattgta 1800 cttccagccttatacttcgttggcccaaagttgtcagaagaggttgcaggtcatcctgaa 1860 ctactaaacctctacaaagtcacatctacttgtggcagactactgaatgattggagaagt 1920 tttaagagagaatccgaggaaggtaagctcaacgctattagtttatacatgatccactcc 1980 ggtggtgcttctacagaagaggaaacaatcgaacatttcaaaggtttgattgattctcag 2040 agaaggcaactgttacaattggtgttgcaagagaaggatagtatcatacctagaccatgt 2100 aaagatctattttggaatatgattaagttattacacactttctacatgaaagatgatggc 2160 ttcacctcaaatgagatgaggaatgtagttaaggcaatcattaacgaaccaatctcactg 2220 gatgaattatga 2232 SEQIDNO:238 MSCIRPWFCPSSISATLTDPASKLVTGEFKTTSLNFHGTKERIKKMFDKIELSVSSYDTA 60 WVAMVPSPDCPETPCFPECTKWILENQLGDGSWSLPHGNPLLVKDALSSTLACILALKRW 120 GIGEEQINKGLRFIELNSASVTDNEQHKPIGFDIIFPGMIEYAKDLDLNLPLKPTDINSM 180 LHRRALELTSGGGKNLEGRRAYLAYVSEGIGKLQDWEMAMKYQRKNGSLFNSPSTTAAAF 240 IHIQDAECLHYIRSLLQKFGNAVPTIYPLDIYARLSMVDALERLGIDRHFRKERKFVLDE 300 TYRFWLQGEEEIFSDNATCALAFRILRLNGYDVSLEDHFSNSLGGYLKDSGAALELYRAL 360 QLSYPDESLLEKQNSRTSYFLKQGLSNVSLCGDRLRKNIIGEVHDALNFPDHANLQRLAI 420 RRRIKHYATDDTRILKTSYRCSTIGNQDFLKLAVEDFNICQSIQREEFKHIERWVVERRL 480 DKLKFARQKEAYCYFSAAATLFAPELSDARMSWAKNGVLTTVVDDFFDVGGSEEELVNLI 540 ELIERWDVNGSADFCSEEVEIIYSAIHSTISEIGDKSFGWQGRDVKSHVIKIWLDLLKSM 600 LTEAQWSSNKSVPTLDEYMTTAHVSFALGPIVLPALYFVGPKLSEEVAGHPELLNLYKVM 660 STCGRLLNDWRSFKRESEEGKLNAISLYMIHSGGASTEEETIEHFKGLIDSQRRQLLQLV 720 LQEKDSIIPRPCKDLFWNMIKLLHTFYMKDDGFTSNEMRNVVKAIINEPISLDEL 775 SEQIDNO:239 atggaatttgatgaaccattggttgacgaagcaagatctttagtgcagcgtactttacaa 60 gattatgatgacagatacggcttcggtactatgtcatgtgctgcttatgatacagcctgg 120 gtgtctttagttacaaaaacagtcgatgggagaaaacaatggcttttcccagagtgtttt 180 gaatttctactagaaacacaatctgatgccggaggatgggaaatcgggaattcagcacca 240 atcgacggtatattgaatacagctgcatccttacttgctctaaaacgtcacgttcaaact 300 gagcaaatcatccaacctcaacatgaccataaggatctagcaggtagagctgaacgtgcc 360 gctgcatctttgagagcacaattggctgcattggatgtgtctacaactgaacacgtcggt 420 tttgagataattgttcctgcaatgctagacccattagaagccgaagatccatctctagtt 480 ttcgattttccagctaggaaacctttgatgaagattcatgatgctaagatgagtagattc 540 aggccagaatacttgtatggcaaacaaccaatgaccgccttacattcattagaggctttc 600 ataggcaaaatcgacttcgataaggtaagacaccaccgtacccatgggtctatgatgggt 660 tctccttcatctaccgcagcctacttaatgcacgcttcacaatgggatggtgactcagag 720 gcttaccttagacacgtgattaaacacgcagcagggcagggaactggtgctgtaccatct 780 gctttcccatcaacacattttgagtcatcttggattcttaccacattgtttagagctgga 840 ttttcagcttctcatcttgcctgtgatgagttgaacaagttggtcgagatacttgagggc 900 tcattcgagaaggaaggtggggcaatcggttacgctccagggtttcaagcagatgttgat 960 gatactgctaaaacaataagtacattagcagtccttggaagagatgctacaccaagacaa 1020 atgatcaaggtatttgaagctaatacacattttagaacataccctggtgaaagagatcct 1080 tctttgacagctaattgtaatgctctatcagccttactacaccaaccagatgcagcaatg 1140 tatggatctcaaattcaaaagattaccaaatttgtctgtgactattggtggaagtctgat 1200 ggtaagattaaagataagtggaacacttgctacttgtacccatctgtcttattagttgag 1260 gttttggttgatcttgttagtttattggagcagggtaaattgcctgatgttttggatcaa 1320 gagcttcaatacagagtcgccatcacattgttccaagcatgtttaaggccattactagac 1380 caagatgccgaaggatcatggaacaagtctatcgaagccacagcctacggcatccttatc 1440 ctaactgaagctaggagagtttgtttcttcgacagattgtctgagccattgaatgaggca 1500 atccgtagaggtatcgctttcgccgactctatgtctggaactgaagctcagttgaactac 1560 atttggatcgaaaaggttagttacgcacctgcattattgactaaatcctatttgttagca 1620 gcaagatgggctgctaagtctcctttaggcgcttccgtaggctcttctttgtggactcca 1680 ccaagagaaggattggataagcatgtcagattattccatcaagctgagttattcagatcc 1740 cttccagaatgggaattaagagcctccatgattgaagcagctttgttcacaccacttcta 1800 agagcacatagactagacgttttccctagacaagatgtaggtgaagacaaatatcttgat 1860 gtagttccattcttttggactgccgctaacaacagagatagaacttacgcttccactcta 1920 ttcctttacgatatgtgttttatcgcaatgttaaacttccagttagacgaattcatggag 1980 gccacagccggtatcttattcagagatcatatggatgatttgaggcaattgattcatgat 2040 cttttggcagagaaaacttccccaaagagttctggtagaagtagtcagggcacaaaagat 2100 gctgactcaggtatagaggaagacgtgtcaatgtccgattcagcttcagattcccaggat 2160 agaagtccagaatacgacttggttttcagtgcattgagtacctttacaaaacatgtcttg 2220 caacacccatctatacaaagtgcctctgtatgggatagaaaactacttgctagagagatg 2280 aaggcttacttacttgctcatatccaacaagcagaagattcaactccattgtctgaattg 2340 aaagatgtgcctcaaaagactgatgtaacaagagtttctacatctactactaccttcttt 2400 aactgggttagaacaacttccgcagaccatatatcctgcccatactccttccactttgta 2460 gcatgccatctaggcgcagcattgtcacctaaagggtctaacggtgattgctatccttca 2520 gctggtgagaagttcttggcagctgcagtctgcagacatttggccaccatgtgtagaatg 2580 tacaacgatcttggatcagctgaacgtgattctgatgaaggtaatttgaactccttggac 2640 ttccctgaattcgccgattccgcaggaaacggagggatagaaattcagaaggccgctcta 2700 ttaaggttagctgagtttgagagagattcatacttagaggccttccgtcgtttacaagat 2760 gaatccaatagagttcacggtccagccggtggtgatgaagccagattgtccagaaggaga 2820 atggcaatccttgaattcttcgcccagcaggtagatttgtacggtcaagtatacgtcatt 2880 agggatatttccgctcgtattcctaaaaacgaggttgagaaaaagagaaaattggatgat 2940 gctttcaattga 2952 SEQIDNO:240 MEFDEPLVDEARSLVQRTLQDYDDRYGFGTMSCAAYDTAWVSLVTKTVDGRKQWLFPECF 60 EFLLETQSDAGGWEIGNSAPIDGILNTAASLLALKRHVQTEQIIQPQHDHKDLAGRAERA 120 AASLRAQLAALDVSTTEHVGFEIIVPAMLDPLEAEDPSLVFDFPARKPLMKIHDAKMSRF 180 RPEYLYGKQPMTALHSLEAFIGKIDFDKVRHHRTHGSMMGSPSSTAAYLMHASQWDGDSE 240 AYLRHVIKHAAGQGTGAVPSAFPSTHFESSWILTTLFRAGFSASHLACDELNKLVEILEG 300 SFEKEGGAIGYAPGFQADVDDTAKTISTLAVLGRDATPRQMIKVFEANTHFRTYPGERDP 360 SLTANCNALSALLHQPDAAMYGSQIQKITKFVCDYWWKSDGKIKDKWNTCYLYPSVLLVE 420 VLVDLVSLLEQGKLPDVLDQELQYRVAITLFQACLRPLLDQDAEGSWNKSIEATAYGILI 480 LTEARRVCFFDRLSEPLNEAIRRGIAFADSMSGTEAQLNYIWIEKVSYAPALLTKSYLLA 540 ARWAAKSPLGASVGSSLWTPPREGLDKHVRLFHQAELFRSLPEWELRASMIEAALFTPLL 600 RAHRLDVFPRQDVGEDKYLDVVPFFWTAANNRDRTYASTLFLYDMCFIAMLNFQLDEFME 660 ATAGILFRDHMDDLRQLIHDLLAEKTSPKSSGRSSQGTKDADSGIEEDVSMSDSASDSQD 720 RSPEYDLVFSALSTFTKHVLQHPSIQSASVWDRKLLAREMKAYLLAHIQQAEDSTPLSEL 780 KDVPQKTDVTRVSTSTTTFFNWVRTTSADHISCPYSFHFVACHLGAALSPKGSNGDCYPS 840 AGEKFLAAAVCRHLATMCRMYNDLGSAERDSDEGNLNSLDFPEFADSAGNGGIEIQKAAL 900 LRLAEFERDSYLEAFRRLQDESNRVHGPAGGDEARLSRRRMAILEFFAQQVDLYGQVYVI 960 RDISARIPKNEVEKKRKLDDAFN 983 SEQIDNO:241 atggcttctagtacacttatccaaaacagatcatgtggcgtcacatcatctatgtcaagt 60 tttcaaatcttcagaggtcaaccactaagatttcctggcactagaaccccagctgcagtt 120 caatgcttgaaaaagaggagatgccttaggccaaccgaatccgtactagaatcatctcct 180 ggctctggttcatatagaatagtaactggcccttctggaattaaccctagttctaacggg 240 cacttgcaagagggttccttgactcacaggttaccaataccaatggaaaaatctatcgat 300 aacttccaatctactctatatgtgtcagatatttggtctgaaacactacagagaactgaa 360 tgtttgctacaagtaactgaaaacgtccagatgaatgagtggattgaggaaattagaatg 420 tactttagaaatatgactttaggtgaaatttccatgtccccttacgacactgcttgggtg 480 gctagagttccagcgttggacggttctcatgggcctcaattccacagatctttgcaatgg 540 attatcgacaaccaattaccagatggggactggggcgaaccttctcttttcttgggttac 600 gatagagtttgtaatactttagcctgtgtgattgcgttgaaaacatggggtgttggggca 660 caaaacgttgaaagaggaattcagttcctacaatctaacatatacaagatggaggaagat 720 gacgctaatcatatgccaataggattcgaaatcgtattccctgctatgatggaagatgcc 780 aaagcattaggtttggatttgccatacgatgctactattttgcaacagatttcagccgaa 840 agagagaaaaagatgaaaaagatcccaatggcaatggtgtacaaatacccaaccacttta 900 cttcactccttagaaggcttgcatagagaagttgattggaataagttgttacaattacaa 960 tctgaaaatggtagttttctttattcacctgcttcaaccgcatgcgccttaatgtacact 1020 aaggacgttaaatgttttgattacttaaaccagttgttgatcaagttcgaccacgcatgc 1080 ccaaatgtatatccagtcgatctattcgaaagattatggatggttgacagattgcagaga 1140 ttagggatctccagatactttgaaagagagattagagattgtttacaatacgtctacaga 1200 tattggaaagattgtggaatcggatgggcttctaactcttccgtacaagatgttgatgat 1260 acagccatggcgtttagacttttaaggactcatggtttcgacgtaaaggaagattgcttt 1320 agacagtttttcaaggacggagaattcttctgcttcgcaggccaatcatctcaagcagtt 1380 acaggcatgtttaatctttcaagagccagtcaaacattgtttccaggagaatctttattg 1440 aaaaaggctagaaccttctctagaaacttcttgagaacaaagcatgagaacaacgaatgt 1500 ttcgataaatggatcattactaaagatttggctggtgaagtcgagtataacttgaccttc 1560 ccatggtatgcctctttgcctagattagaacataggacatacttagatcaatatggaatc 1620 gatgatatctggataggcaaatctttatacaaaatgcctgctgttaccaacgaagttttc 1680 ctaaagttggcaaaggcagactttaacatgtgtcaagctctacacaaaaaggaattggaa 1740 caagtgataaagtggaacgcgtcctgtcaattcagagatcttgaattcgccagacaaaaa 1800 tcagtagaatgctattttgctggtgcagccacaatgttcgaaccagaaatggttcaagct 1860 agattagtctgggcaagatgttgtgtattgacaactgtcttagacgattactttgaccac 1920 gggacacctgttgaggaacttagagtgtttgttcaagctgtcagaacatggaatccagag 1980 ttgatcaacggtttgccagagcaagctaaaatcttgtttatgggcttatacaaaacagtt 2040 aacacaattgcagaggaagcattcatggcacagaaaagagacgtccatcatcatttgaaa 2100 cactattgggacaagttgataacaagtgccctaaaggaggccgaatgggcagagtcaggt 2160 tacgtcccaacatttgatgaatacatggaagtagctgaaatttctgttgctctagaacca 2220 attgtctgtagtaccttgttctttgcgggtcatagactagatgaggatgttctagatagt 2280 tacgattaccatctagttatgcatttggtaaacagagtcggtagaatcttgaatgatata 2340 caaggcatgaagagggaggcttcacaaggtaagatctcatcagttcaaatctacatggag 2400 gaacatccatctgttccatctgaggccatggcgatcgctcatcttcaagagttagttgat 2460 aattcaatgcagcaattgacatacgaagttcttaggttcactgcggttccaaaaagttgt 2520 aagagaatccacttgaatatggctaaaatcatgcatgccttctacaaggatactgatgga 2580 ttctcatcccttactgcaatgacaggattcgtcaaaaaggttcttttcgaacctgtgcct 2640 gagtaa 2646 SEQIDNO:242 MASSTLIQNRSCGVTSSMSSFQIFRGQPLRFPGTRTPAAVQCLKKRRCLRPTESVLESSP 60 GSGSYRIVTGPSGINPSSNGHLQEGSLTHRLPIPMEKSIDNFQSTLYVSDIWSETLQRTE 120 CLLQVTENVQMNEWIEEIRMYFRNMTLGEISMSPYDTAWVARVPALDGSHGPQFHRSLQW 180 IIDNQLPDGDWGEPSLFLGYDRVCNTLACVIALKTWGVGAQNVERGIQFLQSNIYKMEED 240 DANHMPIGFEIVFPAMMEDAKALGLDLPYDATILQQISAEREKKMKKIPMAMVYKYPTTL 300 LHSLEGLHREVDWNKLLQLQSENGSFLYSPASTACALMYTKDVKCFDYLNQLLIKFDHAC 360 PNVYPVDLFERLWMVDRLQRLGISRYFEREIRDCLQYVYRYWKDCGIGWASNSSVQDVDD 420 TAMAFRLLRTHGFDVKEDCFRQFFKDGEFFCFAGQSSQAVTGMFNLSRASQTLFPGESLL 480 KKARTFSRNFLRTKHENNECFDKWIITKDLAGEVEYNLTFPWYASLPRLEHRTYLDQYGI 540 DDIWIGKSLYKMPAVTNEVFLKLAKADFNMCQALHKKELEQVIKWNASCQFRDLEFARQK 600 SVECYFAGAATMFEPEMVQARLVWARCCVLTTVLDDYFDHGTPVEELRVFVQAVRTWNPE 660 LINGLPEQAKILFMGLYKTVNTIAEEAFMAQKRDVHHHLKHYWDKLITSALKEAEWAESG 720 YVPTFDEYMEVAEISVALEPIVCSTLFFAGHRLDEDVLDSYDYHLVMHLVNRVGRILNDI 780 QGMKREASQGKISSVQIYMEEHPSVPSEAMAIAHLQELVDNSMQQLTYEVLRFTAVPKSC 840 KRIHLNMAKIMHAFYKDTDGFSSLTAMTGFVKKVLFEPVPE 881 SEQIDNO:243 atgcctggtaaaattgaaaatggtaccccaaaggacctcaagactggaaatgattttgtt 60 tctgctgctaagagtttactagatcgagctttcaaaagtcatcattcctactacggatta 120 tgctcaacttcatgtcaagtttatgatacagcttgggttgcaatgattccaaaaacaaga 180 gataatgtaaaacagtggttgtttccagaatgtttccattacctcttaaaaacacaagcc 240 gcagatggctcatggggttcattgcctacaacacagacagcgggtatcctagatacagcc 300 tcagctgtgctggcattattgtgccacgcacaagagcctttacaaatattggatgtatct 360 ccagatgaaatggggttgagaatagaacacggtgtcacatccttgaaacgtcaattagca 420 gtttggaatgatgtggaggacaccaaccatattggcgtcgagtttatcataccagcctta 480 ctttccatgctagaaaaggaattagatgttccatcttttgaatttccatgtaggtccatc 540 ttagagagaatgcacggggagaaattaggtcatttcgacctggaacaagtttacggcaag 600 ccaagctcattgttgcactcattggaagcatttctcggtaagctagattttgatcgacta 660 tcacatcacctataccacggcagtatgatggcatctccatcttcaacggctgcttatctt 720 attggggctacaaaatgggatgacgaagccgaagattacctaagacatgtaatgcgtaat 780 ggtgcaggacatgggaatggaggtatttctggtacatttccaactactcatttcgaatgt 840 agctggattatagcaacgttgttaaaggttggctttactttgaagcaaattgacggcgat 900 ggcttaagaggtttatcaaccatcttacttgaggcgcttcgtgatgagaatggtgtcata 960 ggctttgcccctagaacagcagatgtagatgacacagccaaagctctattggccttgtca 1020 ttggtaaaccagccagtgtcacctgatatcatgattaaggtctttgagggcaaagaccat 1080 tttaccacttttggttcagaaagagatccatcattgacttccaacctgcacgtcctttta 1140 tctttacttaaacaatctaacttgtctcaataccatcctcaaatcctcaaaacaacatta 1200 ttcacttgtagatggtggtggggttccgatcattgtgtcaaagacaaatggaatttgagt 1260 cacctatatccaactatgttgttggttgaagccttcactgaagtgctccatctcattgac 1320 ggtggtgaattgtctagtctgtttgatgaatcctttaagtgtaagattggtcttagcatc 1380 tttcaagcggtacttagaataatcctcacccaagacaacgacggctcttggagaggatac 1440 agagaacagacgtgttacgcaatattggctttagttcaagcgagacatgtatgctttttc 1500 actcacatggttgacagactgcaatcatgtgttgatcgaggtttctcatggttgaaatct 1560 tgctcttttcattctcaagacctgacttggacctctaaaacagcttatgaagtgggtttc 1620 gtagctgaagcatataaactagctgctttacaatctgcttccctggaggttcctgctgcc 1680 accattggacattctgtcacgtctgccgttccatcaagtgatcttgaaaaatacatgaga 1740 ttggtgagaaaaactgcgttattctctccactggatgagtggggtctaatggcttctatc 1800 atcgaatcttcatttttcgtaccattactgcaggcacaaagagttgaaatataccctaga 1860 gataatatcaaggtggacgaagataagtacttgtctattatcccattcacatgggtcgga 1920 tgcaataataggtctagaactttcgcaagtaacagatggctatacgatatgatgtacctt 1980 tcattactcggctatcaaaccgacgagtacatggaagctgtagctgggccagtgtttggg 2040 gatgtttccttgttacatcaaacaattgataaggtgattgataatacaatgggtaacctt 2100 gcgagagccaatggaacagtacacagtggtaatggacatcagcacgaatctcctaatata 2160 ggtcaagtcgaggacaccttgactcgtttcacaaattcagtcttgaatcacaaagacgtc 2220 cttaactctagctcatctgatcaagatactttgagaagagagtttagaacattcatgcac 2280 gctcatataacacaaatcgaagataactcacgattcagtaagcaagcctcatccgatgcg 2340 ttttcctctcctgaacaatcttactttcaatgggtgaactcaactggtggctcacatgtc 2400 gcttgcgcctattcatttgccttctctaattgcctcatgtctgcaaatttgttgcagggt 2460 aaagacgcatttccaagcggaacgcaaaagtacttaatctcctctgttatgagacatgcc 2520 acaaacatgtgtagaatgtataacgactttggctctattgccagagacaacgctgagaga 2580 aatgttaatagtattcattttcctgagtttactctctgtaacggaacttctcaaaaccta 2640 gatgaaaggaaggaaagacttctgaaaatcgcaacttacgaacaagggtatttggataga 2700 gcactagaggccttggaaagacagagtagagatgatgccggagacagagctggatctaaa 2760 gatatgagaaagttgaaaatcgttaagttattctgtgatgttacggacttatacgatcag 2820 ctctacgttatcaaagatttgtcatcctctatgaagtaa 2859 SEQIDNO:244 MPGKIENGTPKDLKTGNDFVSAAKSLLDRAFKSHHSYYGLCSTSCQVYDTAWVAMIPKTR 60 DNVKQWLFPECFHYLLKTQAADGSWGSLPTTQTAGILDTASAVLALLCHAQEPLQILDVS 120 PDEMGLRIEHGVTSLKRQLAVWNDVEDTNHIGVEFIIPALLSMLEKELDVPSFEFPCRSI 180 LERMHGEKLGHFDLEQVYGKPSSLLHSLEAFLGKLDFDRLSHHLYHGSMMASPSSTAAYL 240 IGATKWDDEAEDYLRHVMRNGAGHGNGGISGTFPTTHFECSWIIATLLKVGFTLKQIDGD 300 GLRGLSTILLEALRDENGVIGFAPRTADVDDTAKALLALSLVNQPVSPDIMIKVFEGKDH 360 FTTFGSERDPSLTSNLHVLLSLLKQSNLSQYHPQILKTTLFTCRWWWGSDHCVKDKWNLS 420 HLYPTMLLVEAFTEVLHLIDGGELSSLFDESFKCKIGLSIFQAVLRIILTQDNDGSWRGY 480 REQTCYAILALVQARHVCFFTHMVDRLQSCVDRGFSWLKSCSFHSQDLTWTSKTAYEVGF 540 VAEAYKLAALQSASLEVPAATIGHSVTSAVPSSDLEKYMRLVRKTALFSPLDEWGLMASI 600 IESSFFVPLLQAQRVEIYPRDNIKVDEDKYLSIIPFTWVGCNNRSRTFASNRWLYDMMYL 660 SLLGYQTDEYMEAVAGPVFGDVSLLHQTIDKVIDNTMGNLARANGTVHSGNGHQHESPNI 720 GQVEDTLTRFTNSVLNHKDVLNSSSSDQDTLRREFRTFMHAHITQIEDNSRFSKQASSDA 780 FSSPEQSYFQWVNSTGGSHVACAYSFAFSNCLMSANLLQGKDAFPSGTQKYLISSVMRHA 840 TNMCRMYNDFGSIARDNAERNVNSIHFPEFTLCNGTSQNLDERKERLLKIATYEQGYLDR 900 ALEALERQSRDDAGDRAGSKDMRKLKIVKLFCDVTDLYDQLYVIKDLSSSMK 952 SEQIDNO:245 aagcttactagtaaaatggacggtgtcatcgatatgcaaaccattccattgagaaccgct 60 attgctattggtggtactgctgttgctttggttgttgcattatacttttggttcttgaga 120 tcctacgcttccccatctcatcattctaatcatttgccaccagtacctgaagttccaggt 180 gttccagttttgggtaatttgttgcaattgaaagaaaaaaagccttacatgaccttcacc 240 aagtgggctgaaatgtatggtccaatctactctattagaactggtgctacttccatggtt 300 gttgtctcttctaacgaaatcgccaaagaagttgttgttaccagattcccatctatctct 360 accagaaaattgtcttacgccttgaaggttttgaccgaagataagtctatggttgccatg 420 tctgattatcacgattaccataagaccgtcaagagacatattttgactgctgttttgggt 480 ccaaacgcccaaaaaaagtttagagcacatagagacaccatgatggaaaacgtttccaat 540 gaattgcatgccttcttcgaaaagaacccaaatcaagaagtcaacttgagaaagatcttc 600 caatcccaattattcggtttggctatgaagcaagccttgggtaaagatgttgaatccatc 660 tacgttaaggatttggaaaccaccatgaagagagaagaaatcttcgaagttttggttgtc 720 gatccaatgatgggtgctattgaagttgattggagagactttttcccatacttgaaatgg 780 gttccaaacaagtccttcgaaaacatcatccatagaatgtacactagaagagaagctgtt 840 atgaaggccttgatccaagaacacaagaaaagaattgcctccggtgaaaacttgaactcc 900 tacattgattacttgttgtctgaagcccaaaccttgaccgataagcaattattgatgtct 960 ttgtgggaacctattatcgaatcttctgataccactatggttactactgaatgggctatg 1020 tacgaattggctaagaatccaaacatgcaagacagattatacgaagaaatccaatccgtt 1080 tgcggttccgaaaagattactgaagaaaacttgtcccaattgccatacttgtacgctgtt 1140 ttccaagaaactttgagaaagcactgtccagttcctattatgccattgagatatgttcac 1200 gaaaacaccgttttgggtggttatcatgttccagctggtactgaagttgctattaacatc 1260 tacggttgcaacatggataagaaggtctgggaaaatccagaagaatggaatccagaaaga 1320 ttcttgtccgaaaaagaatccatggacttgtacaaaactatggcttttggtggtggtaaa 1380 agagtttgcgctggttctttacaagccatggttatttcttgcattggtatcggtagattg 1440 gtccaagattttgaatggaagttgaaggatgatgccgaagaagatgttaacactttgggt 1500 ttgactacccaaaagttgcatccattattggccttgattaacccaagaaagtaactcgag 1560 ccgcgg 1566 SEQIDNO:246 MDGVIDMQTIPLRTAIAIGGTAVALVVALYFWFLRSYASPSHHSNHLPPVPEVPGVPVLG 60 NLLQLKEKKPYMTFTKWAEMYGPIYSIRTGATSMVVVSSNEIAKEVVVTRFPSISTRKLS 120 YALKVLTEDKSMVAMSDYHDYHKTVKRHILTAVLGPNAQKKFRAHRDTMMENVSNELHAF 180 FEKNPNQEVNLRKIFQSQLFGLAMKQALGKDVESIYVKDLETTMKREEIFEVLVVDPMMG 240 AIEVDWRDFFPYLKWVPNKSFENIIHRMYTRREAVMKALIQEHKKRIASGENLNSYIDYL 300 LSEAQTLTDKQLLMSLWEPIIESSDTTMVTTEWAMYELAKNPNMQDRLYEEIQSVCGSEK 360 ITEENLSQLPYLYAVFQETLRKHCPVPIMPLRYVHENTVLGGYHVPAGTEVAINIYGCNM 420 DKKVWENPEEWNPERFLSEKESMDLYKTMAFGGGKRVCAGSLQAMVISCIGIGRLVQDFE 480 WKLKDDAEEDVNTLGLTTQKLHPLLALINPRK 512 SEQIDNO:247 atggccaccctccttgagcatttccaagctatgccctttgccatccctattgcactggct 60 gctctgtcttggctgttcctcttttacatcaaagtttcattcttttccaacaagagtgct 120 caggctaagctccctcctgtgccagtggttcctgggctgccggtgattgggaatttactg 180 caactcaaggagaagaaaccctaccagacttttacaaggtgggctgaggagtatggacca 240 atctattctatcaggactggtgcttccaccatggtcgttctcaataccacccaagttgca 300 aaagaggccatggtgaccagatatttatccatctcaaccagaaagctatcaaacgcacta 360 aagattcttactgctgataaatgtatggttgcaataagtgactacaacgattttcacaag 420 atgataaagcgatacatactctcaaatgttcttggacctagtgctcagaagcgtcaccgg 480 agcaacagagataccttgagagctaatgtctgcagccgattgcattctcaagtaaagaac 540 tctcctcgagaagctgtgaatttcagaagagtttttgagtgggaactctttggaattgca 600 ttgaagcaagcctttggaaaggacatagaaaagcccatttatgtggaggaacttggcact 660 acactgtcaagagatgagatctttaaggttctagtgcttgacataatggagggtgcaatt 720 gaggttgattggagagatttcttcccttacctgagatggattccgaatacgcgcatggaa 780 acaaaaattcagcgactctatttccgcaggaaagcagtgatgactgccctgatcaacgag 840 cagaagaagcgaattgcttcaggagaggaaatcaactgttatatcgacttcttgcttaag 900 gaagggaagacactgacaatggaccaaataagtatgttgctttgggagacggttattgaa 960 acagcagatactacaatggtaacgacagaatgggctatgtatgaagttgctaaagactca 1020 aagcgtcaggatcgtctctatcaggaaatccaaaaggtttgtggatcggagatggttaca 1080 gaggaatacttgtcccaactgccgtacctgaatgcagttttccatgaaacgctaaggaag 1140 cacagtccggctgcgttagttcctttaagatatgcacatgaagatacccaactaggaggt 1200 tactacattccagctggaactgagattgctataaacatatacgggtgtaacatggacaag 1260 catcaatgggaaagccctgaggaatggaaaccggagagatttttggacccgaaatttgat 1320 cctatggatttgtacaagaccatggcttttggggctggaaagagggtatgtgctggttct 1380 cttcaggcaatgttaatagcgtgcccgacgattggtaggctggtgcaggagtttgagtgg 1440 aagctgagagatggagaagaagaaaatgtagatactgttgggctcaccactcacaaacgc 1500 tatccaatgcatgcaatcctgaagccaagaagtta 1535 SEQIDNO:248 atggctaccttgttggaacattttcaagctatgccattcgctattccaattgctttggct 60 gctttgtcttggttgtttttgttctacatcaaggtttctttcttctccaacaaatccgct 120 caagctaaattgccaccagttccagttgttccaggtttgccagttattggtaatttgttg 180 caattgaaagaaaagaagccataccaaaccttcactagatgggctgaagaatatggtcca 240 atctactctattagaactggtgcttctactatggttgtcttgaacactactcaagttgcc 300 aaagaagctatggttaccagatacttgtctatctctaccagaaagttgtccaacgccttg 360 aaaattttgaccgctgataagtgcatggttgccatttctgattacaacgatttccacaag 420 atgatcaagagatatatcttgtctaacgttttgggtccatctgcccaaaaaagacataga 480 tctaacagagataccttgagagccaacgtttgttctagattgcattcccaagttaagaac 540 tctccaagagaagctgtcaactttagaagagttttcgaatgggaattattcggtatcgct 600 ttgaaacaagccttcggtaaggatattgaaaagccaatctacgtcgaagaattgggtact 660 actttgtccagagatgaaatcttcaaggttttggtcttggacattatggaaggtgccatt 720 gaagttgattggagagattttttcccatacttgcgttggattccaaacaccagaatggaa 780 actaagatccaaagattatactttagaagaaaggccgttatgaccgccttgattaacgaa 840 caaaagaaaagaattgcctccggtgaagaaatcaactgctacatcgatttcttgttgaaa 900 gaaggtaagaccttgaccatggaccaaatctctatgttgttgtgggaaaccgttattgaa 960 actgctgataccacaatggttactactgaatgggctatgtacgaagttgctaaggattct 1020 aaaagacaagacagattataccaagaaatccaaaaggtctgcggttctgaaatggttaca 1080 gaagaatacttgtcccaattgccatacttgaatgctgttttccacgaaactttgagaaaa 1140 cattctccagctgctttggttccattgagatatgctcatgaagatactcaattgggtggt 1200 tattacattccagccggtactgaaattgccattaacatctacggttgcaacatggacaaa 1260 caccaatgggaatctccagaagaatggaagccagaaagatttttggatcctaagtttgac 1320 ccaatggacttgtacaaaactatggcttttggtgctggtaaaagagtttgcgctggttct 1380 ttacaagctatgttgattgcttgtccaaccatcggtagattggttcaagaatttgaatgg 1440 aagttgagagatggtgaagaagaaaacgttgatactgttggtttgaccacccataagaga 1500 tatccaatgcatgctattttgaagccaagatcttaa 1536 SEQIDNO:249 MATLLEHFQAMPFAIPIALAALSWLFLFYIKVSFFSNKSAQAKLPPVPVVPGLPVIGNLL 60 QLKEKKPYQTFTRWAEEYGPIYSIRTGASTMVVLNTTQVAKEAMVTRYLSISTRKLSNAL 120 KILTADKCMVAISDYNDFHKMIKRYILSNVLGPSAQKRHRSNRDTLRANVCSRLHSQVKN 180 SPREAVNFRRVFEWELFGIALKQAFGKDIEKPIYVEELGTTLSRDEIFKVLVLDIMEGAI 240 EVDWRDFFPYLRWIPNTRMETKIQRLYFRRKAVMTALINEQKKRIASGEEINCYIDFLLK 300 EGKTLTMDQISMLLWETVIETADTTMVTTEWAMYEVAKDSKRQDRLYQEIQKVCGSEMVT 360 EEYLSQLPYLNAVFHETLRKHSPAALVPLRYAHEDTQLGGYYIPAGTEIAINIYGCNMDK 420 HQWESPEEWKPERFLDPKFDPMDLYKTMAFGAGKRVCAGSLQAMLIACPTIGRLVQEFEW 480 KLRDGEEENVDTVGLTTHKRYPMHAILKPRS 511 SEQIDNO:250 aagcttactagtaaaatggcctccatcacccatttcttacaagattttcaagctactcca 60 ttcgctactgcttttgctgttggtggtgtttctttgttgatattcttcttcttcatccgt 120 ggtttccactctactaagaaaaacgaatattacaagttgccaccagttccagttgttcca 180 ggtttgccagttgttggtaatttgttgcaattgaaagaaaagaagccatacaagactttc 240 ttgagatgggctgaaattcatggtccaatctactctattagaactggtgcttctaccatg 300 gttgttgttaactctactcatgttgccaaagaagctatggttaccagattctcttcaatc 360 tctaccagaaagttgtccaaggctttggaattattgacctccaacaaatctatggttgcc 420 acctctgattacaacgaatttcacaagatggtcaagaagtacatcttggccgaattattg 480 ggtgctaatgctcaaaagagacacagaattcatagagacaccttgatcgaaaacgtcttg 540 aacaaattgcatgcccataccaagaattctccattgcaagctgttaacttcagaaagatc 600 ttcgaatctgaattattcggtttggctatgaagcaagccttgggttatgatgttgattcc 660 ttgttcgttgaagaattgggtactaccttgtccagagaagaaatctacaacgttttggtc 720 agtgacatgttgaagggtgctattgaagttgattggagagactttttcccatacttgaaa 780 tggatcccaaacaagtccttcgaaatgaagattcaaagattggcctctagaagacaagcc 840 gttatgaactctattgtcaaagaacaaaagaagtccattgcctctggtaagggtgaaaac 900 tgttacttgaattacttgttgtccgaagctaagactttgaccgaaaagcaaatttccatt 960 ttggcctgggaaaccattattgaaactgctgatacaactgttgttaccactgaatgggct 1020 atgtacgaattggctaaaaacccaaagcaacaagacagattatacaacgaaatccaaaac 1080 gtctgcggtactgataagattaccgaagaacatttgtccaagttgccttacttgtctgct 1140 gtttttcacgaaaccttgagaaagtattctccatctccattggttccattgagatacgct 1200 catgaagatactcaattgggtggttattatgttccagccggtactgaaattgctgttaat 1260 atctacggttgcaacatggacaagaatcaatgggaaactccagaagaatggaagccagaa 1320 agatttttggacgaaaagtacgatccaatggacatgtacaagactatgtcttttggttcc 1380 ggtaaaagagtttgcgctggttctttacaagctagtttgattgcttgtacctccatcggt 1440 agattggttcaagaatttgaatggagattgaaagacggtgaagttgaaaacgttgatacc 1500 ttgggtttgactacccataagttgtatccaatgcaagctatcttgcaacctagaaactga 1560 ctcgagccgcgg 1572 SEQIDNO:251 MASITHFLQDFQATPFATAFAVGGVSLLIFFFFIRGFHSTKKNEYYKLPPVPVVPGLPVV 60 GNLLQLKEKKPYKTFLRWAEIHGPIYSIRTGASTMVVVNSTHVAKEAMVTRFSSISTRKL 120 SKALELLTSNKSMVATSDYNEFHKMVKKYILAELLGANAQKRHRIHRDTLIENVLNKLHA 180 HTKNSPLQAVNFRKIFESELFGLAMKQALGYDVDSLFVEELGTTLSREEIYNVLVSDMLK 240 GAIEVDWRDFFPYLKWIPNKSFEMKIQRLASRRQAVMNSIVKEQKKSIASGKGENCYLNY 300 LLSEAKTLTEKQISILAWETIIETADTTVVTTEWAMYELAKNPKQQDRLYNEIQNVCGTD 360 KITEEHLSKLPYLSAVFHETLRKYSPSPLVPLRYAHEDTQLGGYYVPAGTEIAVNIYGCN 420 MDKNQWETPEEWKPERFLDEKYDPMDMYKTMSFGSGKRVCAGSLQASLIACTSIGRLVQE 480 FEWRLKDGEVENVDTLGLTTHKLYPMQAILQPRN 514 SEQIDNO:252 atgatttccttgttgttgggttttgttgtctcctccttcttgtttatcttcttcttgaaa 60 aaattgttgttcttcttcagtcgtcacaaaatgtccgaagtttctagattgccatctgtt 120 ccagttccaggttttccattgattggtaacttgttgcaattgaaagaaaagaagccacac 180 aagactttcaccaagtggtctgaattatatggtccaatctactctatcaagatgggttcc 240 tcttctttgatcgtcttgaactctattgaaaccgccaaagaagctatggtcagtagattc 300 tcttcaatctctaccagaaagttgtctaacgctttgactgttttgacctgcaacaaatct 360 atggttgctacctctgattacgatgactttcataagttcgtcaagagatgcttgttgaac 420 ggtttgttgggtgctaatgctcaagaaagaaaaagacattacagagatgccttgatcgaa 480 aacgttacctctaaattgcatgcccataccagaaatcatccacaagaaccagttaacttc 540 agagccattttcgaacacgaattattcggtgttgctttgaaacaagccttcggtaaagat 600 gtcgaatccatctatgtaaaagaattgggtgtcaccttgtccagagatgaaattttcaag 660 gttttggtccacgacatgatggaaggtgctattgatgttgattggagagatttcttccca 720 tacttgaaatggatcccaaacaactctttcgaagccagaattcaacaaaagcacaagaga 780 agattggctgttatgaacgccttgatccaagacagattgaatcaaaacgattccgaatcc 840 gatgatgactgctacttgaatttcttgatgtctgaagctaagaccttgaccatggaacaa 900 attgctattttggtttgggaaaccattatcgaaactgctgataccactttggttactact 960 gaatgggctatgtacgaattggccaaacatcaatctgttcaagatagattattcaaagaa 1020 atccaatccgtctgcggtggtgaaaagatcaaagaagaacaattgccaagattgccttac 1080 gtcaatggtgtttttcacgaaaccttgagaaagtattctccagctccattggttccaatt 1140 agatacgctcatgaagatacccaaattggtggttatcatattccagccggttctgaaatt 1200 gccattaacatctacggttgcaacatggataagaagagatgggaaagacctgaagaatgg 1260 tggccagaaagatttttggaagatagatacgaatcctccgacttgcataagactatggct 1320 tttggtgctggtaaaagagtttgtgctggtgctttacaagctagtttgatggctggtatt 1380 gctatcggtagattggttcaagaattcgaatggaagttgagagatggtgaagaagaaaac 1440 gttgatacttacggtttgacctcccaaaagttgtatccattgatggccattatcaaccca 1500 agaagatcttaa 1512 SEQIDNO:253 MASMISLLLGFVVSSFLFIFFLKKLLFFFSRHKMSEVSRLPSVPVPGFPLIGNLLQLKEK 60 KPHKTFTKWSELYGPIYSIKMGSSSLIVLNSIETAKEAMVSRFSSISTRKLSNALTVLTC 120 NKSMVATSDYDDFHKFVKRCLLNGLLGANAQERKRHYRDALIENVTSKLHAHTRNHPQEP 180 VNFRAIFEHELFGVALKQAFGKDVESIYVKELGVTLSRDEIFKVLVHDMMEGAIDVDWRD 240 FFPYLKWIPNNSFEARIQQKHKRRLAVMNALIQDRLNQNDSESDDDCYLNFLMSEAKTLT 300 MEQIAILVWETIIETADTTLVTTEWAMYELAKHQSVQDRLFKEIQSVCGGEKIKEEQLPR 360 LPYVNGVFHETLRKYSPAPLVPIRYAHEDTQIGGYHIPAGSEIAINIYGCNMDKKRWERP 420 EEWWPERFLEDRYESSDLHKTMAFGAGKRVCAGALQASLMAGIAIGRLVQEFEWKLRDGE 480 EENVDTYGLTSQKLYPLMAIINPRRS 506 SEQIDNO:254 aagcttactagtaaaatggacatgatgggtattgaagctgttccatttgctactgctgtt 60 gttttgggtggtatttccttggttgttttgatcttcatcagaagattcgtttccaacaga 120 aagagatccgttgaaggtttgccaccagttccagatattccaggtttaccattgattggt 180 aacttgttgcaattgaaagaaaagaagccacataagacctttgctagatgggctgaaact 240 tacggtccaattttctctattagaactggtgcttctaccatgatcgtcttgaattcttct 300 gaagttgccaaagaagctatggtcactagattctcttcaatctctaccagaaagttgtcc 360 aacgccttgaagattttgaccttcgataagtgtatggttgccacctctgattacaacgat 420 tttcacaaaatggtcaagggtttcatcttgagaaacgttttaggtgctccagcccaaaaa 480 agacatagatgtcatagagataccttgatcgaaaacatctctaagtacttgcatgcccat 540 gttaagacttctccattggaaccagttgtcttgaagaagattttcgaatccgaaattttc 600 ggtttggctttgaaacaagccttgggtaaggatatcgaatccatctatgttgaagaattg 660 ggtactaccttgtccagagaagaaatttttgccgttttggttgttgatccaatggctggt 720 gctattgaagttgattggagagattttttcccatacttgtcctggattccaaacaagtct 780 atggaaatgaagatccaaagaatggattttagaagaggtgctttgatgaaggccttgatt 840 ggtgaacaaaagaaaagaatcggttccggtgaagaaaagaactcctacattgatttcttg 900 ttgtctgaagctaccactttgaccgaaaagcaaattgctatgttgatctgggaaaccatc 960 atcgaaatttccgatacaactttggttacctctgaatgggctatgtacgaattggctaaa 1020 gacccaaatagacaagaaatcttgtacagagaaatccacaaggtttgcggttctaacaag 1080 ttgactgaagaaaacttgtccaagttgccatacttgaactctgttttccacgaaaccttg 1140 agaaagtattctccagctccaatggttccagttagatatgctcatgaagatactcaattg 1200 ggtggttaccatattccagctggttctcaaattgccattaacatctacggttgcaacatg 1260 aacaaaaagcaatgggaaaatcctgaagaatggaagccagaaagattcttggacgaaaag 1320 tatgacttgatggacttgcataagactatggcttttggtggtggtaaaagagtttgtgct 1380 ggtgctttacaagcaatgttgattgcttgcacttccatcggtagattcgttcaagaattt 1440 gaatggaagttgatgggtggtgaagaagaaaacgttgatactgttgctttgacctcccaa 1500 aaattgcatccaatgcaagccattattaaggccagagaatgactcgagccgcgg 1554 SEQIDNO:255 MDMMGIEAVPFATAVVLGGISLVVLIFIRRFVSNRKRSVEGLPPVPDIPGLPLIGNLLQL 60 KEKKPHKTFARWAETYGPIFSIRTGASTMIVLNSSEVAKEAMVTRFSSISTRKLSNALKI 120 LTFDKCMVATSDYNDFHKMVKGFILRNVLGAPAQKRHRCHRDTLIENISKYLHAHVKTSP 180 LEPVVLKKIFESEIFGLALKQALGKDIESIYVEELGTTLSREEIFAVLVVDPMAGAIEVD 240 WRDFFPYLSWIPNKSMEMKIQRMDFRRGALMKALIGEQKKRIGSGEEKNSYIDFLLSEAT 300 TLTEKQIAMLIWETIIEISDTTLVTSEWAMYELAKDPNRQEILYREIHKVCGSNKLTEEN 360 LSKLPYLNSVFHETLRKYSPAPMVPVRYAHEDTQLGGYHIPAGSQIAINIYGCNMNKKQW 420 ENPEEWKPERFLDEKYDLMDLHKTMAFGGGKRVCAGALQAMLIACTSIGRFVQEFEWKLM 480 GGEEENVDTVALTSQKLHPMQAIIKARE 508 SEQIDNO:256 aagcttaaaatgagtaagtctaatagtatgaattctacatcacacgaaaccctttttcaa 60 caattggtcttgggtttggaccgtatgccattgatggatgttcactggttgatctacgtt 120 gctttcggcgcatggttatgttcttatgtgatacatgttttatcatcttcctctacagta 180 aaagtgccagttgttggatacaggtctgtattcgaacctacatggttgcttagacttaga 240 ttcgtctgggaaggtggctctatcataggtcaagggtacaataagtttaaagactctatt 300 ttccaagttaggaaattgggaactgatattgtcattataccacctaactatattgatgaa 360 gtgagaaaattgtcacaggacaagactagatcagttgaacctttcattaatgattttgca 420 ggtcaatacacaagaggcatggttttcttgcaatctgacttacaaaaccgtgttatacaa 480 caaagactaactccaaaattggtttccttgaccaaggtcatgaaggaagagttggattat 540 gctttaacaaaagagatgcctgatatgaaaaatgacgaatgggtagaagtagatatcagt 600 agtataatggtgagattgatttccaggatctccgccagagtctttctagggcctgaacac 660 tgtcgtaaccaggaatggttgactactacagcagaatattcagaatcacttttcattaca 720 gggtttatcttaagagttgtacctcatatcttaagaccattcatcgcccctctattacct 780 tcatacaggactctacttagaaacgtttcaagtggtagaagagtcatcggtgacatcata 840 agatctcagcaaggggatggtaacgaagatatactttcctggatgagagatgctgccaca 900 ggagaggaaaagcaaatcgataacattgctcagagaatgttaattctttctttagcatca 960 atccacactactgcgatgaccatgacacatgccatgtacgatctatgtgcttgccctgag 1020 tacattgaaccattaagagatgaagttaaatctgttgttggggcttctggctgggacaag 1080 acagcgttaaacagatttcataagttggactccttcctaaaagagtcacaaagattcaac 1140 ccagtattcttattgacattcaatagaatctaccatcaatctatgaccttatcagatggc 1200 actaacattccatctggaacacgtattgctgttccatcacacgcaatgttgcaagattct 1260 gcacatgtcccaggtccaaccccacctactgaatttgatggattcagatatagtaagata 1320 cgttctgatagtaactacgcacaaaagtacctattctccatgaccgattcttcaaacatg 1380 gctttcggatacggcaagtatgcttgtccaggtagattttacgcgtctaatgagatgaaa 1440 ctaacattagccattttgttgctacaatttgagttcaaactaccagatggtaaaggtcgt 1500 cctagaaatatcactatcgattctgatatgattccagacccaagagctagactttgcgtc 1560 agaaaaagatcacttagagatgaatgaccgcgg 1593 SEQIDNO:257 MSKSNSMNSTSHETLFQQLVLGLDRMPLMDVHWLIYVAFGAWLCSYVIHVLSSSSTVKVP 60 VVGYRSVFEPTWLLRLRFVWEGGSIIGQGYNKFKDSIFQVRKLGTDIVIIPPNYIDEVRK 120 LSQDKTRSVEPFINDFAGQYTRGMVFLQSDLQNRVIQQRLTPKLVSLTKVMKEELDYALT 180 KEMPDMKNDEWVEVDISSIMVRLISRISARVFLGPEHCRNQEWLTTTAEYSESLFITGFI 240 LRVVPHILRPFIAPLLPSYRTLLRNVSSGRRVIGDIIRSQQGDGNEDILSWMRDAATGEE 300 KQIDNIAQRMLILSLASIHTTAMTMTHAMYDLCACPEYIEPLRDEVKSVVGASGWDKTAL 360 NRFHKLDSFLKESQRFNPVFLLTFNRIYHQSMTLSDGTNIPSGTRIAVPSHAMLQDSAHV 420 PGPTPPTEFDGFRYSKIRSDSNYAQKYLFSMTDSSNMAFGYGKYACPGRFYASNEMKLTL 480 AILLLQFEFKLPDGKGRPRNITIDSDMIPDPRARLCVRKRSLRDE 525 SEQIDNO:258 aagcttaaaatggaagatcctactgtcttatatgcttgtcttgccattgcagttgcaact 60 ttcgttgttagatggtacagagatccattgagatccatcccaacagttggtggttccgat 120 ttgcctattctatcttacatcggcgcactaagatggacaagacgtggcagagagatactt 180 caagagggatatgatggctacagaggatctacattcaaaatcgcgatgttagaccgttgg 240 atcgtgatcgcaaatggtcctaaactagctgatgaagtcagacgtagaccagatgaagag 300 ttaaactttatggacggattaggagcattcgtccaaactaagtacaccttaggtgaagct 360 attcataacgatccataccatgtcgatatcataagagaaaaactaacaagaggccttcca 420 gccgtgcttcctgatgtcattgaagagttgacacttgcggttagacagtacattccaaca 480 gaaggtgatgaatgggtgtccgtaaactgttcaaaggccgcaagagatattgttgctaga 540 gcttctaatagagtctttgtaggtttgcctgcttgcagaaaccaaggttacttagatttg 600 gcaatagactttacattgtctgttgtcaaggatagagccatcatcaatatgtttccagaa 660 ttgttgaagccaatagttggcagagttgtaggtaacgccaccagaaatgttcgtagagct 720 gttccttttgttgctccattggtggaggaaagacgtagacttatggaagagtacggtgaa 780 gactggtctgaaaaacctaatgatatgttacagtggataatggatgaagctgcatccaga 840 gatagttcagtgaaggcaatcgcagagagattgttaatggtgaacttcgcggctattcat 900 acctcatcaaacactatcactcatgctttgtaccaccttgccgaaatgcctgaaactttg 960 caaccacttagagaagagatcgaaccattagtcaaagaggagggctggaccaaggctgct 1020 atgggaaaaatgtggtggttagattcatttctaagagaatctcaaagatacaatggcatt 1080 aacatcgtatctttaactagaatggctgacaaagatattacattgagtgatggcacattt 1140 ttgccaaaaggtactctagtggccgttccagcgtattctactcatagagatgatgctgtc 1200 tacgctgatgccttagtattcgatcctttcagattctcacgtatgagagcgagagaaggt 1260 gaaggtacaaagcaccagttcgttaatacttcagtcgagtacgttccatttggtcacgga 1320 aagcatgcttgtccaggaagattcttcgccgcaaacgaattgaaagcaatgttggcttac 1380 attgttctaaactatgatgtaaagttgcctggtgacggtaaacgtccattgaacatgtat 1440 tggggtccaacagttttgcctgcaccagcaggccaagtattgttcagaaagagacaagtt 1500 agtctataaccgcgg 1515 SEQIDNO:259 MEDPTVLYACLAIAVATFVVRWYRDPLRSIPTVGGSDLPILSYIGALRWTRRGREILQEG 60 YDGYRGSTFKIAMLDRWIVIANGPKLADEVRRRPDEELNFMDGLGAFVQTKYTLGEAIHN 120 DPYHVDIIREKLTRGLPAVLPDVIEELTLAVRQYIPTEGDEWVSVNCSKAARDIVARASN 180 RVFVGLPACRNQGYLDLAIDFTLSVVKDRAIINMFPELLKPIVGRVVGNATRNVRRAVPF 240 VAPLVEERRRLMEEYGEDWSEKPNDMLQWIMDEAASRDSSVKAIAERLLMVNFAAIHTSS 300 NTITHALYHLAEMPETLQPLREEIEPLVKEEGWTKAAMGKMWWLDSFLRESQRYNGINIV 360 SLTRMADKDITLSDGTFLPKGTLVAVPAYSTHRDDAVYADALVFDPFRFSRMRAREGEGT 420 KHQFVNTSVEYVPFGHGKHACPGRFFAANELKAMLAYIVLNYDVKLPGDGKRPLNMYWGP 480 TVLPAPAGQVLFRKRQVSL 499 SEQIDNO:260 atggcatttttctctatgatttcaattttgttgggatttgttatttcttctttcatcttc 60 atctttttcttcaaaaagttacttagttttagtaggaaaaacatgtcagaagtttctact 120 ttgccaagtgttccagtagtgcctggttttccagttattgggaatttgttgcaactaaag 180 gagaaaaagcctcataaaactttcactagatggtcagagatatatggacctatctactct 240 ataaagatgggttcttcatctcttattgtattgaacagtacagaaactgctaaggaagca 300 atggtcactagattttcatcaatatctaccagaaaattgtcaaacgccctaacagttcta 360 acctgcgataagtctatggtcgccacttctgattatgatgacttccacaaattagttaag 420 agatgtttgctaaatggacttcttggtgctaatgctcaaaagagaaaaagacactacaga 480 gatgctttgattgaaaatgtgagttccaagctacatgcacacgctagagatcatccacaa 540 gagccagttaactttagagcaattttcgaacacgaattgtttggtgtagcattaaagcaa 600 gccttcggtaaagacgtagaatccatatacgtcaaggagttaggcgtaacattatcaaaa 660 gatgaaatctttaaggtgcttgtacatgatatgatggagggtgcaattgatgtagattgg 720 agagatttcttcccatatttgaaatggatccctaataagtcttttgaagctaggatacaa 780 caaaagcacaagagaagactagctgttatgaacgcacttatacaggacagattgaagcaa 840 aatgggtctgaatcagatgatgattgttaccttaacttcttaatgtctgaggctaaaaca 900 ttgactaaggaacagatcgcaatccttgtctgggaaacaatcattgaaacagcagatact 960 accttagtcacaactgaatgggccatatacgagctagccaaacatccatctgtgcaagat 1020 aggttgtgtaaggagatccagaacgtgtgtggtggagagaaattcaaggaagagcagttg 1080 tcacaagttccttaccttaacggcgttttccatgaaaccttgagaaaatactcacctgca 1140 ccattagttcctattagatacgcccacgaagatacacaaatcggtggctaccatgttcca 1200 gctgggtccgaaattgctataaacatctacgggtgcaacatggacaaaaagagatgggaa 1260 agaccagaagattggtggccagaaagattcttagatgatggcaaatatgaaacatctgat 1320 ttgcataaaacaatggctttcggagctggcaaaagagtgtgtgccggtgctctacaagcc 1380 tccctaatggctggtatcgctattggtagattggtccaagagttcgaatggaaacttaga 1440 gatggtgaagaggaaaatgtcgatacttatgggttaacatctcaaaagttatacccacta 1500 atggcaatcatcaatcctagaagatcctaa 1530 SEQIDNO:261 MAFFSMISILLGFVISSFIFIFFFKKLLSFSRKNMSEVSTLPSVPVVPGFPVIGNLLQLK 60 EKKPHKTFTRWSEIYGPIYSIKMGSSSLIVLNSTETAKEAMVTRFSSISTRKLSNALTVL 120 TCDKSMVATSDYDDFHKLVKRCLLNGLLGANAQKRKRHYRDALIENVSSKLHAHARDHPQ 180 EPVNFRAIFEHELFGVALKQAFGKDVESIYVKELGVTLSKDEIFKVLVHDMMEGAIDVDW 240 RDFFPYLKWIPNKSFEARIQQKHKRRLAVMNALIQDRLKQNGSESDDDCYLNFLMSEAKT 300 LTKEQIAILVWETIIETADTTLVTTEWAIYELAKHPSVQDRLCKEIQNVCGGEKFKEEQL 360 SQVPYLNGVFHETLRKYSPAPLVPIRYAHEDTQIGGYHVPAGSEIAINIYGCNMDKKRWE 420 RPEDWWPERFLDDGKYETSDLHKTMAFGAGKRVCAGALQASLMAGIAIGRLVQEFEWKLR 480 DGEEENVDTYGLTSQKLYPLMAIINPRRS 509 SEQIDNO:262 atgcaatcagattcagtcaaagtctctccatttgatttggtttccgctgctatgaatggc 60 aaggcaatggaaaagttgaacgctagtgaatctgaagatccaacaacattgcctgcacta 120 aagatgctagttgaaaatagagaattgttgacactgttcacaacttccttcgcagttctt 180 attgggtgtcttgtatttctaatgtggagacgttcatcctctaaaaagctggtacaagat 240 ccagttccacaagttatcgttgtaaagaagaaagagaaggagtcagaggttgatgacggg 300 aaaaagaaagtttctattttctacggcacacaaacaggaactgccgaaggttttgctaaa 360 gcattagtcgaggaagcaaaagtgagatatgaaaagacctctttcaaggttatcgatcta 420 gatgactacgctgcagatgatgatgaatatgaggaaaaactgaaaaaggaatccttagcc 480 ttcttcttcttggccacatacggtgatggtgaacctactgataatgctgctaacttctac 540 aagtggttcacagaaggcgacgataaaggtgaatggctgaaaaagttacaatacggagta 600 tttggtttaggtaacagacaatatgaacatttcaacaagatcgctattgtagttgatgat 660 aaacttactgaaatgggagccaaaagattagtaccagtaggattaggggatgatgatcag 720 tgtatagaagatgacttcaccgcctggaaggaattggtatggccagaattggatcaactt 780 ttaagggacgaagatgatacttctgtgactaccccatacactgcagccgtattggagtac 840 agagtggtttaccatgataaaccagcagactcatatgctgaagatcaaacccatacaaac 900 ggtcatgttgttcatgatgcacagcatccttcaagatctaatgtggctttcaaaaaggaa 960 ctacacacctctcaatcagataggtcttgtactcacttagaattcgatatttctcacaca 1020 ggactgtcttacgaaactggcgatcacgttggcgtttattccgagaacttgtccgaagtt 1080 gtcgatgaagcactaaaactgttagggttatcaccagacacatacttctcagtccatgct 1140 gataaggaggatgggacacctatcggtggtgcttcactaccaccaccttttcctccttgc 1200 acattgagagacgctctaaccagatacgcagatgtcttatcctcacctaaaaaggtagct 1260 ttgctggcattggctgctcatgctagtgatcctagtgaagccgataggttaaagttcctg 1320 gcttcaccagccggaaaagatgaatatgcacaatggatcgtcgccaaccaacgttctttg 1380 ctagaagtgatgcaaagttttccatctgccaagcctccattaggtgtgttcttcgcagca 1440 gtagctccacgtttacaaccaagatactactctatcagttcatctcctaagatgtctcct 1500 aacagaatacatgttacatgtgctttggtgtacgagactactccagcaggcagaattcac 1560 agaggattgtgttcaacctggatgaaaaatgctgtccctttaacagagtcacctgattgc 1620 tctcaagcatccattttcgttagaacatcaaatttcagacttccagtggatccaaaagtt 1680 ccagtcattatgataggaccaggcactggtcttgccccattcaggggctttcttcaagag 1740 agattggccttgaaggaatctggtacagaattgggttcttctatctttttctttggttgc 1800 cgtaatagaaaagttgactttatctacgaggacgagcttaacaattttgttgagacagga 1860 gcattgtcagaattgatcgtcgcattttcaagagaagggactgccaaagagtacgttcag 1920 cacaagatgagtcaaaaagcctccgatatatggaaacttctaagtgaaggtgcctatctt 1980 tatgtctgtggcgatgcaaagggcatggccaaggatgtccatagaactctgcatacaatt 2040 gttcaggaacaagggagtctggattcttccaaggctgaattgtacgtcaaaaacttacag 2100 atgtctggaagatacttaagagatgtttggtaa 2133 SEQIDNO:263 MQSDSVKVSPFDLVSAAMNGKAMEKLNASESEDPTTLPALKMLVENRELLTLFTTSFAVL 60 IGCLVFLMWRRSSSKKLVQDPVPQVIVVKKKEKESEVDDGKKKVSIFYGTQTGTAEGFAK 120 ALVEEAKVRYEKTSFKVIDLDDYAADDDEYEEKLKKESLAFFFLATYGDGEPTDNAANFY 180 KWFTEGDDKGEWLKKLQYGVFGLGNRQYEHFNKIAIVVDDKLTEMGAKRLVPVGLGDDDQ 240 CIEDDFTAWKELVWPELDQLLRDEDDTSVTTPYTAAVLEYRVVYHDKPADSYAEDQTHTN 300 GHVVHDAQHPSRSNVAFKKELHTSQSDRSCTHLEFDISHTGLSYETGDHVGVYSENLSEV 360 VDEALKLLGLSPDTYFSVHADKEDGTPIGGASLPPPFPPCTLRDALTRYADVLSSPKKVA 420 LLALAAHASDPSEADRLKFLASPAGKDEYAQWIVANQRSLLEVMQSFPSAKPPLGVFFAA 480 VAPRLQPRYYSISSSPKMSPNRIHVTCALVYETTPAGRIHRGLCSTWMKNAVPLTESPDC 540 SQASIFVRTSNFRLPVDPKVPVIMIGPGTGLAPFRGFLQERLALKESGTELGSSIFFFGC 600 RNRKVDFIYEDELNNFVETGALSELIVAFSREGTAKEYVQHKMSQKASDIWKLLSEGAYL 660 YVCGDAKGMAKDVHRTLHTIVQEQGSLDSSKAELYVKNLQMSGRYLRDVW 710 SEQIDNO:264 atgaaggtcagtccattcgaattcatgtccgctattatcaagggtagaatggacccatct 60 aactcctcatttgaatctactggtgaagttgcctccgttatctttgaaaacagagaattg 120 gttgccatcttgaccacttctattgctgttatgattggttgcttcgttgtcttgatgtgg 180 agaagagctggttctagaaaggttaagaatgtcgaattgccaaagccattgattgtccat 240 gaaccagaacctgaagttgaagatggtaagaagaaggtttccatcttcttcggtactcaa 300 actggtactgctgaaggttttgctaaggctttggctgatgaagctaaagctagatacgaa 360 aaggctaccttcagagttgttgatttggatgattatgctgccgatgatgaccaatacgaa 420 gaaaaattgaagaacgaatccttcgccgttttcttgttggctacttatggtgatggtgaa 480 cctactgataatgctgctagattttacaagtggttcgccgaaggtaaagaaagaggtgaa 540 tggttgcaaaacttgcactatgctgtttttggtttgggtaacagacaatacgaacacttc 600 aacaagattgctaaggttgccgacgaattattggaagctcaaggtggtaatagattggtt 660 aaggttggtttaggtgatgacgatcaatgcatcgaagatgatttttctgcttggagagaa 720 tctttgtggccagaattggatatgttgttgagagatgaagatgatgctactactgttact 780 actccatatactgctgctgtcttggaatacagagttgtctttcatgattctgctgatgtt 840 gctgctgaagataagtcttggattaacgctaatggtcatgctgttcatgatgctcaacat 900 ccattcagatctaacgttgtcgtcagaaaagaattgcatacttctgcctctgatagatcc 960 tgttctcatttggaattcaacatttccggttccgctttgaattacgaaactggtgatcat 1020 gttggtgtctactgtgaaaacttgactgaaactgttgatgaagccttgaacttgttgggt 1080 ttgtctccagaaacttacttctctatctacaccgataacgaagatggtactccattgggt 1140 ggttcttcattgccaccaccatttccatcatgtactttgagaactgctttgaccagatac 1200 gctgatttgttgaactctccaaaaaagtctgctttgttggctttagctgctcatgcttct 1260 aatccagttgaagctgatagattgagatacttggcttctccagctggtaaagatgaatat 1320 gcccaatctgttatcggttcccaaaagtctttgttggaagttatggctgaattcccatct 1380 gctaaaccaccattaggtgttttttttgctgctgttgctccaagattgcaacctagattc 1440 tactccatttcatcctctccaagaatggctccatctagaatccatgttacttgtgctttg 1500 gtttacgataagatgccaactggtagaattcataagggtgtttgttctacctggatgaag 1560 aattctgttccaatggaaaagtcccatgaatgttcttgggctccaattttcgttagacaa 1620 tccaattttaagttgccagccgaatccaaggttccaattatcatggttggtccaggtact 1680 ggtttggctccttttagaggttttttacaagaaagattggccttgaaagaatccggtgtt 1740 gaattgggtccatccattttgtttttcggttgcagaaacagaagaatggattacatctac 1800 gaagatgaattgaacaacttcgttgaaaccggtgctttgtccgaattggttattgctttt 1860 tctagagaaggtcctaccaaagaatacgtccaacataagatggctgaaaaggcttctgat 1920 atctggaacttgatttctgaaggtgcttacttgtacgtttgtggtgatgctaaaggtatg 1980 gctaaggatgttcatagaaccttgcataccatcatgcaagaacaaggttctttggattct 2040 tccaaagctgaatccatggtcaagaacttgcaaatgaatggtagatacttaagagatgtt 2100 tggtaa 2106 SEQIDNO:265 MKVSPFEFMSAIIKGRMDPSNSSFESTGEVASVIFENRELVAILTTSIAVMIGCFVVLMW 60 RRAGSRKVKNVELPKPLIVHEPEPEVEDGKKKVSIFFGTQTGTAEGFAKALADEAKARYE 120 KATFRVVDLDDYAADDDQYEEKLKNESFAVFLLATYGDGEPTDNAARFYKWFAEGKERGE 180 WLQNLHYAVFGLGNRQYEHFNKIAKVADELLEAQGGNRLVKVGLGDDDQCIEDDFSAWRE 240 SLWPELDMLLRDEDDATTVTTPYTAAVLEYRVVFHDSADVAAEDKSWINANGHAVHDAQH 300 PFRSNVVVRKELHTSASDRSCSHLEFNISGSALNYETGDHVGVYCENLTETVDEALNLLG 360 LSPETYFSIYTDNEDGTPLGGSSLPPPFPSCTLRTALTRYADLLNSPKKSALLALAAHAS 420 NPVEADRLRYLASPAGKDEYAQSVIGSQKSLLEVMAEFPSAKPPLGVFFAAVAPRLQPRF 480 YSISSSPRMAPSRIHVTCALVYDKMPTGRIHKGVCSTWMKNSVPMEKSHECSWAPIFVRQ 540 SNFKLPAESKVPIIMVGPGTGLAPFRGFLQERLALKESGVELGPSILFFGCRNRRMDYIY 600 EDELNNFVETGALSELVIAFSREGPTKEYVQHKMAEKASDIWNLISEGAYLYVCGDAKGM 660 AKDVHRTLHTIMQEQGSLDSSKAESMVKNLQMNGRYLRDVW 701 SEQIDNO:266 MEVTVASSVALSLVFISIVVRWAWSVVNWVWFKPKKLERFLREQGLKGNSYRFLYGDMKE 60 NSILLKQARSKPMNLSTSHDIAPQVTPFVDQTVKAYGKNSFNWVGPIPRVNIMNPEDLKD 120 VLTKNVDFVKPISNPLIKLLATGIAIYEGEKWTKHRRIINPTFHSERLKRMLPSFHQSCN 180 EMVKEWESLVSKEGSSCELDVWPFLENMSADVISRTAFGTSYKKGQKIFELLREQVIYVT 240 KGFQSFYIPGWRFLPTKMNKRMNEINEEIKGLIRGIIIDREQIIKAGEETNDDLLGALME 300 SNLKDIREHGKNNKNVGMSIEDVIQECKLFYFAGQETTSVLLAWTMVLLGQNQNWQDRAR 360 QEVLQVFGSSKPDFDGLAHLKVVTMILLEVLRLYPPVIELIRTIHKKTQLGKLSLPEGVE 420 VRLPTLLIHHDKELWGDDANQFNPERFSEGVSKATKNRLSFFPFGAGPRICIGQNFSMME 480 AKLALALILQHFTFELSPSHAHAPSHRITLQPQYGVRIILHRR 523 SEQIDNO:267 atggaagcatcaagggctagttgtgttgcgctatgtgttgtttgggtgagcatagtaatt 60 acattggcatggagggtgctgaattgggtgtggttgaggccaaagaaactagaaagatgc 120 ttgagggagcaaggccttacaggcaattcttacaggcttttgtttggagacaccaaggat 180 ctctcgaagatgctggaacaaacacaatccaaacccatcaaactctccacctcccatgat 240 atagcgccacgagtcaccccatttttccatcgaactgtgaactctaatggcaagaattct 300 tttgtttggatgggccctataccaagagtgcacatcatgaatccagaagatttgaaagat 360 gccttcaacagacatgatgattttcataagacagtaaaaaatcctatcatgaagtctcca 420 ccaccgggcattgtaggcattgaaggtgagcaatgggctaaacacagaaagattatcaac 480 ccagcattccatttagagaagctaaagggtatggtaccaatattttaccaaagttgtagc 540 gagatgattaacaaatgggagagcttggtgtccaaagagagttcatgtgagttggatgtg 600 tggccttatcttgaaaattttaccagcgatgtgatttcccgagctgcatttggaagtagc 660 tatgaagagggaaggaaaatatttcaactactaagagaggaagcaaaagtttattcggta 720 gctctacgaagtgtttacattccaggatggaggtttctaccaaccaagcagaacaagaag 780 acgaaggaaattcacaatgaaattaaaggcttacttaagggcattataaataaaagggaa 840 gaggcgatgaaggcaggggaagccactaaagatgacttactaggaatacttatggagtcc 900 aacttcagggaaattcaggaacatgggaacaacaaaaatgctggaatgagtattgaagat 960 gtaattggagagtgtaagttgttttactttgctgggcaagagaccacttcggtgttgctt 1020 gtttggacaatgattttactaagccaaaatcaggattggcaagctcgtgcaagagaagag 1080 gtcttgaaagtctttggaagcaacatcccaacctatgaagagctaagtcacctaaaagtt 1140 gtgaccatgattttacttgaagttcttcgattatacccatcagtcgttgcgcttcctcga 1200 accactcacaagaaaacacagcttggaaaattatcattaccagctggagtggaagtctcc 1260 ttgcccatactgcttgttcaccatgacaaagagttgtggggtgaggatgcaaatgagttc 1320 aagccagagaggttttcagagggagtttcaaaggcaacaaagaacaaatttacatactta 1380 cctttcggagggggtccaaggatttgcattggacaaaactttgccatggtggaagctaaa 1440 ttggccttggccctgattttacaacactttgcctttgagctttctccatcctatgctcat 1500 gctccttctgcagttataacccttcaacctcaatttggtgctcatatcattttgcataaa 1560 cgttga 1566 SEQIDNO:268 atggaagcttctagagcatcttgtgttgctttgtgtgttgtttgggtttccatcgttatt 60 actttggcttggagagttttgaattgggtctggttaagaccaaaaaagttggaaagatgc 120 ttgagagaacaaggtttgactggtaactcttacagattgttgttcggtgataccaaggac 180 ttgtctaagatgttggaacaaactcaatccaagcctatcaagttgtctacctctcatgat 240 attgctccaagagttactccattcttccatagaactgttaactccaacggtaagaactct 300 tttgtttggatgggtccaattccaagagtccatattatgaaccctgaagatttgaaggac 360 gctttcaacagacatgatgatttccataagaccgtcaagaacccaattatgaagtctcca 420 ccaccaggtatagttggtattgaaggtgaacaatgggccaaacatagaaagattattaac 480 ccagccttccacttggaaaagttgaaaggtatggttccaatcttctaccaatcctgctct 540 gaaatgattaacaagtgggaatccttggtttccaaagaatcttcctgtgaattggatgtc 600 tggccatatttggaaaacttcacctccgatgttatttccagagctgcttttggttcttct 660 tacgaagaaggtagaaagatcttccaattattgagagaagaagccaaggtttactccgtt 720 gctttgagatctgtttacattccaggttggagattcttgccaactaagcaaaacaaaaag 780 accaaagaaatccacaacgaaatcaagggtttgttgaagggtatcatcaacaagagagaa 840 gaagctatgaaggctggtgaagctacaaaagatgatttgttgggtatcttgatggaatcc 900 aacttcagagaaatccaagaacacggtaacaacaagaatgccggtatgtctattgaagat 960 gttatcggtgaatgcaagttgttctactttgctggtcaagaaactacctccgttttgttg 1020 gtttggaccatgattttgttgtcccaaaatcaagattggcaagctagagctagagaagaa 1080 gtcttgaaagttttcggttctaacatcccaacctacgaagaattgtctcacttgaaggtt 1140 gtcactatgatcttgttggaagtattgagattatacccatccgttgttgcattgccaaga 1200 actactcataagaaaactcaattgggtaaattgtccttgccagctggtgttgaagtttct 1260 ttgccaattttgttagtccaccacgacaaagaattgtggggtgaagatgctaatgaattc 1320 aagccagaaagattctccgaaggtgtttctaaagctaccaagaacaagttcacttacttg 1380 ccatttggtggtggtccaagaatatgtattggtcaaaatttcgctatggtcgaagctaaa 1440 ttggctttggctttgatcttgcaacatttcgctttcgaattgtcaccatcttatgctcat 1500 gctccatctgctgttattacattgcaaccacaatttggtgcccatatcatcttgcataag 1560 agataac 1567 SEQIDNO:269 MEASRASCVALCVVWVSIVITLAWRVLNWVWLRPKKLERCLREQGLTGNSYRLLFGDTKD 60 LSKMLEQTQSKPIKLSTSHDIAPRVTPFFHRTVNSNGKNSFVWMGPIPRVHIMNPEDLKD 120 AFNRHDDFHKTVKNPIMKSPPPGIVGIEGEQWAKHRKIINPAFHLEKLKGMVPIFYQSCS 180 EMINKWESLVSKESSCELDVWPYLENFTSDVISRAAFGSSYEEGRKIFQLLREEAKVYSV 240 ALRSVYIPGWRFLPTKQNKKTKEIHNEIKGLLKGIINKREEAMKAGEATKDDLLGILMES 300 NFREIQEHGNNKNAGMSIEDVIGECKLFYFAGQETTSVLLVWTMILLSQNQDWQARAREE 360 VLKVFGSNIPTYEELSHLKVVTMILLEVLRLYPSVVALPRTTHKKTQLGKLSLPAGVEVS 420 LPILLVHHDKELWGEDANEFKPERFSEGVSKATKNKFTYLPFGGGPRICIGQNFAMVEAK 480 LALALILQHFAFELSPSYAHAPSAVITLQPQFGAHIILHKR 521 SEQIDNO:270 ASWVAVLSVVWVSMVIAWAWRVLNWVWLRPKKLEKCLREQGLAGNSYRLLFGDTKDLSKM 60 LEQTQSKPIKLSTSHDIAPHVTPFFHQTVNSYGKNSFVWMGPIPRVHIMNPEDLKDTFNR 120 HDDFHKVVKNPIMKSLPQGIVGIEGEQWAKHRKIINPAFHLEKLKGMVPIFYRSCSEMIN 180 KWESLVSKESSCELDVWPYLENFTSDVISRAAFGSSYEEGRKIFQLLREEAKIYTVAMRS 240 VYIPGWRFLPTKQNKKAKEIHNEIKGLLKGIINKREEAMKAGEATKDDLLGILMESNFRE 300 IQEHGNNKNAGMSIEDVIGECKLFYFAGQETTSVLLVWTMVLLSQNQDWQARAREEVLQV 360 FGSNIPTYEELSQLKVVTMILLEVLRLYPSVVALPRTTHKKTQLGKLSLPAGVEVSLPIL 420 LVHHDKELWGEDANEFKPERFSEGVSKATKNQFTYFPFGGGPRICIGQNFAMMEAKLALS 480 LILRHFALELSPLYAHAPSVTITLQPQYGAHIILHKR 517 SEQIDNO:271 MEASRPSCVALSVVLVSIVIAWAWRVLNWVWLRPNKLERCLREQGLTGNSYRLLFGDTKE 60 ISMMVEQAQSKPIKLSTTHDIAPRVIPFSHQIVYTYGRNSFVWMGPTPRVTIMNPEDLKD 120 AFNKSDEFQRAISNPIVKSISQGLSSLEGEKWAKHRKIINPAFHLEKLKGMLPTFYQSCS 180 EMINKWESLVFKEGSREMDVWPYLENLTSDVISRAAFGSSYEEGRKIFQLLREEAKFYTI 240 AARSVYIPGWRFLPTKQNKRMKEIHKEVRGLLKGIINKREDAIKAGEAAKGNLLGILMES 300 NFREIQEHGNNKNAGMSIEDVIGECKLFYFAGQETTSVLLVWTLVLLSQNQDWQARAREE 360 VLQVFGTNIPTYDQLSHLKVVTMILLEVLRLYPAVVELPRTTYKKTQLGKFLLPAGVEVS 420 LHIMLAHHDKELWGEDAKEFKPERFSEGVSKATKNQFTYFPFGAGPRICIGQNFAMLEAK 480 LALSLILQHFTFELSPSYAHAPSVTITLHPQFGAHFILHKR 521 SEQIDNO:272 CVALSVVLVSIVIAWAWRVLNWVWLRPNKLERCLREQGLTGNSYRLLFGDTKEISMMVEQ 60 AQSKPIKLSTTHDIAPRVIPFSHQIVYTYGRNSFVWMGPTPRVTIMNPEDLKDAFNKSDE 120 FQRAISNPIVKSISQGLSSLEGEKWAKHRKIINPAFHLEKLKGMLPTFYQSCSEMINKWE 180 SLVFKEGSREMDVWPYLENLTSDVISRAAFGSSYEEGRKIFQLLREEAKFYTIAARSVYI 240 PGWRFLPTKQNKRMKEIHKEVRGLLKGIINKREDAIKAGEAAKGNLLGILMESNFREIQE 300 HGNNKNAGMSIEDVIGECKLFYFAGQETTSVLLVWTLVLLSQNQDWQARAREEVLQVFGT 360 NIPTYDQLSHLKVVTMILLEVLRLYPAVVELPRTTYKKTQLGKFLLPAGVEVSLHIMLAH 420 HDKELWGEDAKEFKPERFSEGVSKATKNQFTYFPFGAGPRICIGQNFAMLEAKLALSLIL 480 QHFTFELSPSYAHAPSVTITLHPQFGAHFILHKR 514 SEQIDNO:273 MGPIPRVHIMNPEDLKDTFNRHDDFHKVVKNPIMKSLPQGIVGIEGDQWAKHRKIINPAF 60 HLEKLKGMVPIFYQSCSEMINIWKSLVSKESSCELDVWPYLENFTSDVISRAAFGSSYEE 120 GRKIFQLLREEAKVYTVAVRSVYIPGWRFLPTKQNKKTKEIHNEIKGLLKGIINKREEAM 180 KAGEATKDDLLGILMESNFREIQEHGNNKNAGMSIEDVIGECKLFYFAGQETTSVLLVWT 240 MVLLSQNQDWQARAREEVLQVFGSNIPTYEELSHLKVVTMILLEVLRLYPSVVALPRTTH 300 KKTQLGKLSLPAGVEVSLPILLVHHDKELWGEDANEFKPERFSEGVSKATKNQFTYFPFG 360 GGPRICIGQNFAMMEAKLALSLILQHFTFELSPQYSHAPSVTITLQPQYGAHLILHKR 418 SEQIDNO:274 atgggtttgttcccattagaggattcctacgcgctggtctttgaaggactagcaataaca 60 ctggctttgtactatctactgtctttcatctacaaaacatctaaaaagacatgtacacct 120 cctaaagcatctggtgaaatcattccaattacaggaatcatattgaatctgctatctggc 180 tcaagtggtctacctattatcttagcacttgcctctttagcagacagatgtggtcctatt 240 ttcaccattaggctgggtattaggagagtgctagtagtatcaaattgggaaatcgctaag 300 gagattttcactacccacgatttgatagtttctaatagaccaaaatacttagccgctaag 360 attcttggtttcaattatgtttcattctctttcgctccatacggcccatattgggtcgga 420 atcagaaagattattgctacaaaactaatgtcttcttccagacttcagaagttgcaattt 480 gtaagagtttttgaactagaaaactctatgaaatctatcagagaatcatggaaggagaaa 540 aaggatgaagagggaaaggtattagttgagatgaaaaagtggttctgggaactgaatatg 600 aacatagtgttaaggacagttgctggtaaacaatacactggtacagttgatgatgccgat 660 gcaaagcgtatctccgagttattcagagaatggtttcactacactggcagatttgtcgtt 720 ggagacgcttttccttttctaggttggttggacctgggcggatacaaaaagacaatggaa 780 ttagttgctagtagattggactcaatggtcagtaaatggttagatgagcatcgtaaaaag 840 caagctaacgatgacaaaaaggaggatatggatttcatggatatcatgatctccatgaca 900 gaagcaaattcaccacttgaaggatacggcactgatactattatcaagaccacatgtatg 960 actttgattgtttcaggagttgatacaacctcaatcgtacttacttgggccttatcactt 1020 ttgttaaacaacagagatactttgaaaaaggcacaagaggaattagatatgtgcgtaggt 1080 aaaggaagacaagtcaacgagtctgatcttgttaacttgatatacttggaagcagtgctt 1140 aaagaggctttaagactttacccagcagcgttcttaggcggaccaagagcattcttggaa 1200 gattgtactgttgctggttatagaattccaaagggcacctgcttgttgattaacatgtgg 1260 aaactgcatagagatccaaacatttggagtgatccttgcgaattcaagccagaaagattt 1320 ttgacacctaatcaaaaggatgttgatgtgatcggtatggatttcgaattgataccattt 1380 ggtgccggcagaagatattgtccaggtactagattggctttacagatgttgcatatcgta 1440 ttagcgacattgctgcaaaacttcgaaatgtcaacaccaaacgatgcgccagtcgatatg 1500 actgcttctgttggcatgacaaatgccaaagcatcacctttagaagtcttgctatcacct 1560 cgtgttaaatggtcctaa 1578 SEQIDNO:275 MGLFPLEDSYALVFEGLAITLALYYLLSFIYKTSKKTCTPPKASGEHPITGHLNLLSGSS 60 GLPHLALASLADRCGPIFTIRLGIRRVLVVSNWEIAKEIFTTHDLIVSNRPKYLAAKILG 120 FNYVSFSFAPYGPYWVGIRKIIATKLMSSSRLQKLQFVRVFELENSMKSIRESWKEKKDE 180 EGKVLVEMKKWFWELNMNIVLRTVAGKQYTGTVDDADAKRISELFREWFHYTGRFVVGDA 240 FPFLGWLDLGGYKKTMELVASRLDSMVSKWLDEHRKKQANDDKKEDMDFMDIMISMTEAN 300 SPLEGYGTDTIIKTTCMTLIVSGVDTTSIVLTWALSLLLNNRDTLKKAQEELDMCVGKGR 360 QVNESDLVNLIYLEAVLKEALRLYPAAFLGGPRAFLEDCTVAGYRIPKGTCLLINMWKLH 420 RDPNIWSDPCEFKPERFLTPNQKDVDVIGMDFELIPFGAGRRYCPGTRLALQMLHIVLAT 480 LLQNFEMSTPNDAPVDMTASVGMTNAKASPLEVLLSPRVKWS 522 SEQIDNO:276 atgatacaagttttaactccaattctactcttcctcatcttcttcgttttctggaaagtc 60 tacaaacatcaaaagactaaaatcaatctaccaccaggttccttcggctggccatttttg 120 ggtgaaaccttagccttacttagagcaggctgggattctgagccagaaagattcgtaaga 180 gagcgtatcaaaaagcatggatctccacttgttttcaagacatcactatttggagacaga 240 ttcgctgttctttgcggtccagctggtaataagtttttgttctgcaacgaaaacaaatta 300 gtggcatcttggtggccagtccctgtaaggaagttgttcggtaaaagtttactcacaata 360 agaggagatgaagcaaaatggatgagaaaaatgctattgtcttacttgggtccagatgca 420 tttgccacacattatgccgttactatggatgttgtaacacgtagacatattgatgtccat 480 tggaggggcaaggaggaagttaatgtatttcaaacagttaagttgtacgcattcgaatta 540 gcttgtagattattcatgaacctagatgacccaaaccacatcgcgaaactcggtagtctt 600 ttcaacattttcctcaaagggatcatcgagcttcctatagacgttcctggaactagattt 660 tactccagtaaaaaggccgcagctgccattagaattgaattgaaaaagctcattaaagct 720 agaaaactcgaattgaaggagggtaaggcgtcttcttcacaggacttgctttctcatcta 780 ttaacatcacctgatgagaatgggatgttcttgacagaagaggaaatagtcgataacatt 840 ctacttttgttattcgctggtcacgatacctctgcactatcaataacacttttgatgaaa 900 accttaggtgaacacagtgatgtgtacgacaaggttttgaaggaacaattagaaatttcc 960 aaaacaaaggaggcttgggaatcactaaagtgggaagatatccagaagatgaagtactca 1020 tggtcagtaatctgtgaagtcatgagattgaatcctcctgtcatagggacatacagagag 1080 gcgttggttgatatcgactatgctggttacactatcccaaaaggatggaagttgcattgg 1140 tcagctgtttctactcaaagagacgaagccaatttcgaagatgtaactagattcgatcca 1200 tccagatttgaaggggcaggccctactccattcacatttgtgcctttcggtggaggtcct 1260 agaatgtgtttaggcaaagagtttgccaggttagaagtgttagcatttctccacaacatt 1320 gttaccaactttaagtgggatcttctaatccctgatgagaagatcgaatatgatccaatg 1380 gctactccagctaagggcttgccaattagacttcatccacaccaagtctaa 1431 SEQIDNO:277 MIQVLTPILLFLIFFVFWKVYKHQKTKINLPPGSFGWPFLGETLALLRAGWDSEPERFVR 60 ERIKKHGSPLVFKTSLFGDRFAVLCGPAGNKFLFCNENKLVASWWPVPVRKLFGKSLLTI 120 RGDEAKWMRKMLLSYLGPDAFATHYAVTMDVVTRRHIDVHWRGKEEVNVFQTVKLYAFEL 180 ACRLFMNLDDPNHIAKLGSLFNIFLKGIIELPIDVPGTRFYSSKKAAAAIRIELKKLIKA 240 RKLELKEGKASSSQDLLSHLLTSPDENGMFLTEEEIVDNILLLLFAGHDTSALSITLLMK 300 TLGEHSDVYDKVLKEQLEISKTKEAWESLKWEDIQKMKYSWSVICEVMRLNPPVIGTYRE 360 ALVDIDYAGYTIPKGWKLHWSAVSTQRDEANFEDVTRFDPSRFEGAGPTPFTFVPFGGGP 420 RMCLGKEFARLEVLAFLHNIVTNFKWDLLIPDEKIEYDPMATPAKGLPIRLHPHQV 476 SEQIDNO:278 atggagtctttagtggttcatacagtaaatgctatctggtgtattgtaatcgtcgggatt 60 ttctcagttggttatcacgtttacggtagagctgtggtcgaacaatggagaatgagaaga 120 tcactgaagctacaaggtgttaaaggcccaccaccatccatcttcaatggtaacgtctca 180 gaaatgcaacgtatccaatccgaagctaaacactgctctggcgataacattatctcacat 240 gattattcttcttcattattcccacacttcgatcactggagaaaacagtacggcagaatc 300 tacacatactctactggattaaagcaacacttgtacatcaatcatccagaaatggtgaag 360 gagctatctcagactaacacattgaacttgggtagaatcacccatataaccaaaagattg 420 aatcctatcttaggtaacggaatcataacctctaatggtcctcattgggcccatcagcgt 480 agaattatcgcctacgagtttactcatgataagatcaagggtatggttggtttgatggtt 540 gagtctgctatgcctatgttgaataagtgggaggagatggtaaagagaggcggagaaatg 600 ggatgcgacataagagttgatgaggacttgaaagatgtttcagcagatgtgattgcaaaa 660 gcctgtttcggatcctcattttctaaaggtaaggctattttctctatgataagagatttg 720 cttacagctatcacaaagagaagtgttctattcagattcaacggattcactgatatggtc 780 tttgggagtaaaaagcatggtgacgttgatatagacgctttagaaatggaattggaatca 840 tccatttgggaaactgtcaaggaacgtgaaatagaatgtaaagatactcacaaaaaggat 900 ctgatgcaattgattttggaaggggcaatgcgttcatgtgacggtaacctttgggataaa 960 tcagcatatagaagatttgttgtagataattgtaaatctatctacttcgcagggcatgat 1020 agtacagctgtctcagtgtcatggtgtttgatgttactggccctaaacccatcatggcaa 1080 gttaagatccgtgatgaaattctgtcttcttgcaaaaatggtattccagatgccgaaagt 1140 atcccaaaccttaaaacagtgactatggttattcaagagacaatgagattataccctcca 1200 gcaccaatcgtcgggagagaagcctctaaagatatcagattgggcgatctagttgttcct 1260 aaaggcgtctgtatatggacactaataccagctttacacagagatcctgagatttgggga 1320 ccagatgcaaacgatttcaaaccagaaagattttctgaaggaatttcaaaggcttgtaag 1380 tatcctcaaagttacattccatttggtctgggtcctagaacatgcgttggtaaaaacttt 1440 ggcatgatggaagtaaaggttcttgtttccctgattgtctccaagttctctttcactcta 1500 tctcctacctaccaacatagtcctagtcacaaacttttagtagaaccacaacatggggtg 1560 gtaattagagtggtttaa 1578 SEQIDNO:279 MESLVVHTVNAIWCIVIVGIFSVGYHVYGRAVVEQWRMRRSLKLQGVKGPPPSIFNGNVS 60 EMQRIQSEAKHCSGDNIISHDYSSSLFPHFDHWRKQYGRIYTYSTGLKQHLYINHPEMVK 120 ELSQTNTLNLGRITHITKRLNPILGNGIITSNGPHWAHQRRIIAYEFTHDKIKGMVGLMV 180 ESAMPMLNKWEEMVKRGGEMGCDIRVDEDLKDVSADVIAKACFGSSFSKGKAIFSMIRDL 240 LTAITKRSVLFRFNGFTDMVFGSKKHGDVDIDALEMELESSIWETVKEREIECKDTHKKD 300 LMQLILEGAMRSCDGNLWDKSAYRRFVVDNCKSIYFAGHDSTAVSVSWCLMLLALNPSWQ 360 VKIRDEILSSCKNGIPDAESIPNLKTVTMVIQETMRLYPPAPIVGREASKDIRLGDLVVP 420 KGVCIWTLIPALHRDPEIWGPDANDFKPERFSEGISKACKYPQSYIPFGLGPRTCVGKNF 480 GMMEVKVLVSLIVSKFSFTLSPTYQHSPSHKLLVEPQHGVVIRVV 525 SEQIDNO:280 atgtacttcctactacaatacctcaacatcacaaccgttggtgtctttgccacattgttt 60 ctctcttattgtttacttctctggagaagtagagcgggtaacaaaaagattgccccagaa 120 gctgccgctgcatggcctattatcggccacctccacttacttgcaggtggatcccatcaa 180 ctaccacatattacattgggtaacatggcagataagtacggtcctgtattcacaatcaga 240 ataggcttgcatagagctgtagttgtctcatcttgggaaatggcaaaggaatgttcaaca 300 gctaatgatcaagtgtcttcttcaagacctgaactattagcttctaagttgttgggttat 360 aactacgccatgtttggtttttcaccatacggttcatactggagagaaatgagaaagatc 420 atctctctcgaattactatctaattccagattggaactattgaaagatgttagagcctca 480 gaagttgtcacatctattaaggaactatacaaattgtgggcggaaaagaagaatgagtca 540 ggattggtttctgtcgagatgaaacaatggttcggagatttgactttaaacgtgatcttg 600 agaatggtggctggtaaaagatacttctccgcgagtgacgcttcagaaaacaaacaggcc 660 cagcgttgtagaagagtcttcagagaattcttccatctctccggcttgtttgtggttgct 720 gatgctataccttttcttggatggctcgattggggaagacacgagaagaccttgaaaaag 780 accgccatagaaatggattccatcgcccaggagtggcttgaggaacatagacgtagaaaa 840 gattctggagatgataattctacccaagatttcatggacgttatgcaatctgtgctagat 900 ggcaaaaatctaggcggatacgatgctgatacgattaacaaggctacatgcttaactctt 960 atatcaggtggcagtgatactactgtagtttctttgacatgggctcttagtcttgtgtta 1020 aacaatagagatactttgaaaaaggcacaggaagagttagacatccaagtcggtaaggaa 1080 agattggttaacgagcaagacatcagtaagttagtttacttgcaagcaatagtaaaagag 1140 acactcagactttatccaccaggtcctttgggtggtttgagacaattcactgaagattgt 1200 acactaggtggctatcacgtttcaaaaggaactagattaatcatgaacttatccaagatt 1260 caaaaagatccacgtatttggtctgatcctactgaattccaaccagagagattccttacg 1320 actcataaagatgtcgatccacgtggtaaacactttgaattcattccattcggtgcagga 1380 agacgtgcatgtcctggtatcacattcggattacaagtactacatctaacattggcatct 1440 ttcttgcatgcgtttgaattttcaacaccatcaaatgagcaggttaacatgagagaatca 1500 ttaggtcttacgaatatgaaatctaccccattagaagttttgatttctccaagactatcc 1560 cttaattgcttcaaccttatgaaaatttga 1590 SEQIDNO:281 MYFLLQYLNITTVGVFATLFLSYCLLLWRSRAGNKKIAPEAAAAWPIIGHLHLLAGGSHQ 60 LPHITLGNMADKYGPVFTIRIGLHRAVVVSSWEMAKECSTANDQVSSSRPELLASKLLGY 120 NYAMFGFSPYGSYWREMRKIISLELLSNSRLELLKDVRASEVVTSIKELYKLWAEKKNES 180 GLVSVEMKQWFGDLTLNVILRMVAGKRYFSASDASENKQAQRCRRVFREFFHLSGLFVVA 240 DAIPFLGWLDWGRHEKTLKKTAIEMDSIAQEWLEEHRRRKDSGDDNSTQDFMDVMQSVLD 300 GKNLGGYDADTINKATCLTLISGGSDTTVVSLTWALSLVLNNRDTLKKAQEELDIQVGKE 360 RLVNEQDISKLVYLQAIVKETLRLYPPGPLGGLRQFTEDCTLGGYHVSKGTRLIMNLSKI 420 QKDPRIWSDPTEFQPERFLTTHKDVDPRGKHFEFIPFGAGRRACPGITFGLQVLHLTLAS 480 FLHAFEFSTPSNEQVNMRESLGLTNMKSTPLEVLISPRLSSCSLYN 526 SEQIDNO:282 atggaacctaacttttacttgtcattactattgttgttcgtgaccttcatttctttaagt 60 ctgtttttcatcttttacaaacaaaagtccccattgaatttgccaccagggaaaatgggt 120 taccctatcataggtgaaagtttagaattcctatccacaggctggaagggacatcctgaa 180 aagttcatatttgatagaatgcgtaagtacagtagtgagttattcaagacttctattgta 240 ggcgaatccacagttgtttgctgtggggcagctagtaacaaattcctattctctaacgaa 300 aacaaactggtaactgcctggtggccagattctgttaacaaaatcttcccaacaacttca 360 ctggattctaatttgaaggaggaatctataaagatgagaaagttgctgccacagttcttc 420 aaaccagaagcacttcaaagatacgtcggcgttatggatgtaatcgcacaaagacatttt 480 gtcactcactgggacaacaaaaatgagatcacagtttatccacttgctaaaagatacact 540 ttcttgcttgcgtgtagactgttcatgtctgttgaggatgaaaatcatgtggcgaaattc 600 tcagacccattccaactaatcgctgcaggcatcatttcacttcctatcgatcttcctggt 660 actccattcaacaaggccataaaggcttcaaatttcattagaaaagagctgataaagatt 720 atcaaacaaagacgtgttgatctggcagagggtacagcatctccaacccaggatatcttg 780 tcacatatgctattaacatctgatgaaaacggtaaatctatgaacgagttgaacattgcc 840 gacaagattcttggactattgataggaggccacgatacagcttcagtagcttgcacattt 900 ctagtgaagtacttaggagaattaccacatatctacgataaagtctaccaagagcaaatg 960 gaaattgccaagtccaaacctgctggggaattgttgaattgggatgacttgaaaaagatg 1020 aagtattcatggaatgtggcatgtgaggtaatgagattgtcaccacctttacaaggtggt 1080 tttagagaggctataactgactttatgtttaacggtttctctattccaaaagggtggaag 1140 ttatactggtccgccaactctacacacaaaaatgcagaatgtttcccaatgcctgagaaa 1200 ttcgatcctaccagatttgaaggtaatggtccagcgccttatacatttgtaccattcggt 1260 ggaggccctagaatgtgtcctggaaaggaatacgctagattagaaatcttggttttcatg 1320 cataatctggtcaaacgttttaagtgggaaaaggttattccagacgaaaagattattgtc 1380 gatccattcccaatcccagctaaagatcttccaatccgtttgtatcctcacaaagcttaa 1440 SEQIDNO:283 MEPNFYLSLLLLFVTFISLSLFFIFYKQKSPLNLPPGKMGYPIIGESLEFLSTGWKGHPE 60 KFIFDRMRKYSSELFKTSIVGESTVVCCGAASNKFLFSNENKLVTAWWPDSVNKIFPTTS 120 LDSNLKEESIKMRKLLPQFFKPEALQRYVGVMDVIAQRHFVTHWDNKNEITVYPLAKRYT 180 FLLACRLFMSVEDENHVAKFSDPFQLIAAGIISLPIDLPGTPFNKAIKASNFIRKELIKI 240 IKQRRVDLAEGTASPTQDILSHMLLTSDENGKSMNELNIADKILGLLIGGHDTASVACTF 300 LVKYLGELPHIYDKVYQEQMEIAKSKPAGELLNWDDLKKMKYSWNVACEVMRLSPPLQGG 360 FREAITDFMFNGFSIPKGWKLYWSANSTHKNAECFPMPEKFDPTRFEGNGPAPYTFVPFG 420 GGPRMCPGKEYARLEILVFMHNLVKRFKWEKVIPDEKIIVDPFPIPAKDLPIRLYPHKA 479 SEQIDNO:284 atggctacatctgattctattgttgatgacaggaagcagttgcatgtggctactttccct 60 tggcttgctttcggtcatatactgccttacctacaactatcaaaactgatagctgaaaaa 120 ggacataaagtgtcattcctttcaacaactagaaacattcaaagattatcttcccacata 180 tcaccattgattaacgtcgttcaattgacacttccaagagtacaggaattaccagaagat 240 gctgaagctacaacagatgtgcatcctgaagatatcccttacttgaaaaaggcatccgat 300 ggattacagcctgaggtcactagattccttgagcaacacagtccagattggatcatatac 360 gactacactcactattggttgccttcaattgcagcatcactaggcatttctagggcacat 420 ttcagtgtaaccacaccttgggccattgcttacatgggtccatccgctgatgctatgatt 480 aacggcagtgatggtagaactaccgttgaagatttgacaaccccaccaaagtggtttcca 540 tttccaactaaagtctgttggagaaaacacgacttagcaagactggttccatacaaggca 600 ccaggaatctcagacggctatagaatgggtttagtccttaaagggtctgactgcctattg 660 tctaagtgttaccatgagtttgggacacaatggctaccacttttggaaacattacaccaa 720 gttcctgtcgtaccagttggtctattacctccagaaatccctggtgatgagaaggacgag 780 acttgggtttcaatcaaaaagtggttagacgggaagcaaaaaggctcagtggtatatgtg 840 gcactgggttccgaagttttagtatctcaaacagaagttgtggaacttgccttaggtttg 900 gaactatctggattgccatttgtctgggcctacagaaaaccaaaaggccctgcaaagtcc 960 gattcagttgaattgccagacggctttgtcgagagaactagagatagagggttggtatgg 1020 acttcatgggctccacaattgagaatcctgagtcacgaatctgtgtgcggtttcctaaca 1080 cattgtggttctggttctatagttgaaggactgatgtttggtcatccacttatcatgttg 1140 ccaatctttggtgaccagcctttgaatgcacgtctgttagaagataaacaagttggaatt 1200 gaaatcccacgtaatgaggaagatggatgtttaaccaaggagtctgtggccagatcatta 1260 cgttccgttgtcgttgaaaaggaaggcgaaatctacaaggccaatgcccgtgaactttca 1320 aagatctacaatgacacaaaagtagagaaggaatatgtttctcaatttgtagattaccta 1380 gagaaaaacgctagagccgtagctattgatcatgaatcctaa 1422 SEQIDNO:285 MATSDSIVDDRKQLHVATFPWLAFGHILPYLQLSKLIAEKGHKVSFLSTTRNIQRLSSHI 60 SPLINVVQLTLPRVQELPEDAEATTDVHPEDIPYLKKASDGLQPEVTRFLEQHSPDWIIY 120 DYTHYWLPSIAASLGISRAHFSVTTPWAIAYMGPSADAMINGSDGRTTVEDLTTPPKWFP 180 FPTKVCWRKHDLARLVPYKAPGISDGYRMGLVLKGSDCLLSKCYHEFGTQWLPLLETLHQ 240 VPVVPVGLLPPEIPGDEKDETWVSIKKWLDGKQKGSVVYVALGSEVLVSQTEVVELALGL 300 ELSGLPFVWAYRKPKGPAKSDSVELPDGFVERTRDRGLVWTSWAPQLRILSHESVCGFLT 360 HCGSGSIVEGLMFGHPLIMLPIFGDQPLNARLLEDKQVGIEIPRNEEDGCLTKESVARSL 420 RSVVVEKEGEIYKANARELSKIYNDTKVEKEYVSQFVDYLEKNARAVAIDHES 473 SEQIDNO:286 atggcagaattagatacacttgatatagtagtattaggtgttatctttttgggtactgtg 60 gcatactttactaagggtaaattgtggggtgttaccaaggatccatacgctaacggattc 120 gctgcaggtggtgcttccaagcctggcagaactagaaacatcgtcgaagctatggaggaa 180 tcaggtaaaaactgtgttgttttctacggcagtcaaacaggtacagcggaggattacgca 240 tcaagacttgcaaaggaaggaaagtccagattcggtttgaacactatgatcgccgatcta 300 gaagattatgacttcgataacttagacactgttccatctgataacatcgttatgtttgta 360 ttggctacttacggtgaaggcgaaccaacagataacgccgtggatttctatgagttcatt 420 actggcgaagatgcctctttcaatgagggcaacgatcctccactaggtaacttgaattac 480 gttgcgttcggtctgggcaacaatacctacgaacactacaactcaatggtcaggaacgtt 540 aacaaggctctagaaaagttaggagctcatagaattggagaagcaggtgagggtgacgac 600 ggagctggaactatggaagaggactttttagcttggaaagatccaatgtgggaagccttg 660 gctaaaaagatgggcttggaggaaagagaagctgtatatgaacctattttcgctatcaat 720 gagagagatgatttgacccctgaagcgaatgaggtatacttgggagaacctaataagcta 780 cacttggaaggtacagcgaaaggtccattcaactcccacaacccatatatcgcaccaatt 840 gcagaatcatacgaacttttctcagctaaggatagaaattgtctgcatatggaaattgat 900 atttctggtagtaatctaaagtatgaaacaggcgaccatatcgcgatctggcctaccaac 960 ccaggtgaagaggtcaacaaatttcttgacattctagatctgtctggtaagcaacattcc 1020 gtcgtaacagtgaaagccttagaacctacagccaaagttccttttccaaatccaactacc 1080 tacgatgctatattgagataccatctggaaatatgcgctccagtttctagacagtttgtc 1140 tcaactttagcagcattcgcccctaatgatgatatcaaagctgagatgaaccgtttggga 1200 tcagacaaagattacttccacgaaaagacaggaccacattactacaatatcgctagattt 1260 ttggcctcagtctctaaaggtgaaaaatggacaaagataccattttctgctttcatagaa 1320 ggccttacaaaactacaaccaagatactattctatctcttcctctagtttagttcagcct 1380 aaaaagattagtattactgctgttgtcgaatctcagcaaattccaggtagagatgaccca 1440 ttcagaggtgtagcgactaactacttgttcgctttgaagcagaaacaaaacggtgatcca 1500 aatccagctccttttggccaatcatacgagttgacaggaccaaggaataagtatgatggt 1560 atacatgttccagtccatgtaagacattctaactttaagctaccatctgatccaggcaaa 1620 cctattatcatgatcggtccaggtaccggtgttgccccttttagaggcttcgtccaagag 1680 agggcaaaacaagccagagatggtgtagaagttggtaaaacactgctgttctttggatgt 1740 agaaagagtacagaagatttcatgtatcaaaaagagtggcaagagtacaaggaagctctt 1800 ggcgacaaattcgaaatgattacagctttttcaagagaaggatctaaaaaggtttatgtt 1860 caacacagactgaaggaaagatcaaaggaagtttctgatcttctatcccaaaaagcatac 1920 ttctacgtttgcggagacgccgcacatatggcacgtgaagtgaacactgtgttagcacag 1980 atcatagcagaaggccgtggtgtatcagaagccaagggtgaggaaattgtcaaaaacatg 2040 agatcagcaaatcaataccaagtgtgttctgatttcgtaactttacactgtaaagagaca 2100 acatacgcgaattcagaattgcaagaggatgtctggagttaa 2142 SEQIDNO:287 MAELDTLDIVVLGVIFLGTVAYFTKGKLWGVTKDPYANGFAAGGASKPGRTRNIVEAMEE 60 SGKNCVVFYGSQTGTAEDYASRLAKEGKSRFGLNTMIADLEDYDFDNLDTVPSDNIVMFV 120 LATYGEGEPTDNAVDFYEFITGEDASFNEGNDPPLGNLNYVAFGLGNNTYEHYNSMVRNV 180 NKALEKLGAHRIGEAGEGDDGAGTMEEDFLAWKDPMWEALAKKMGLEEREAVYEPIFAIN 240 ERDDLTPEANEVYLGEPNKLHLEGTAKGPFNSHNPYIAPIAESYELFSAKDRNCLHMEID 300 ISGSNLKYETGDHIAIWPTNPGEEVNKFLDILDLSGKQHSVVTVKALEPTAKVPFPNPTT 360 YDAILRYHLEICAPVSRQFVSTLAAFAPNDDIKAEMNRLGSDKDYFHEKTGPHYYNIARF 420 LASVSKGEKWTKIPFSAFIEGLTKLQPRYYSISSSSLVQPKKISITAVVESQQIPGRDDP 480 FRGVATNYLFALKQKQNGDPNPAPFGQSYELTGPRNKYDGIHVPVHVRHSNFKLPSDPGK 540 PIIMIGPGTGVAPFRGFVQERAKQARDGVEVGKTLLFFGCRKSTEDFMYQKEWQEYKEAL 600 GDKFEMITAFSREGSKKVYVQHRLKERSKEVSDLLSQKAYFYVCGDAAHMAREVNTVLAQ 660 IIAEGRGVSEAKGEEIVKNMRSANQYQVCSDFVTLHCKETTYANSELQEDVWS 713 SEQIDNO:288 atgcaatcggaatccgttgaagcatcgacgattgatttgatgactgctgttttgaaggac 60 acagtgatcgatacagcgaacgcatctgataacggagactcaaagatgccgccggcgttg 120 gcgatgatgttcgaaattcgtgatctgttgctgattttgactacgtcagttgctgttttg 180 gtcggatgtttcgttgttttggtgtggaagagatcgtccgggaagaagtccggcaaggaa 240 ttggagccgccgaagatcgttgtgccgaagaggcggctggagcaggaggttgatgatggt 300 aagaagaaggttacgattttcttcggaacacaaactggaacggctgaaggtttcgctaag 360 gcacttttcgaagaagcgaaagcgcgatatgaaaaggcagcgtttaaagtgattgatttg 420 gatgattatgctgctgatttggatgagtatgcagagaagctgaagaaggaaacatatgct 480 ttcttcttcttggctacatatggagatggtgagccaactgataatgctgccaaattttat 540 aaatggtttactgagggagacgagaaaggcgtttggcttcaaaaacttcaatatggagta 600 tttggtcttggcaacagacaatatgaacatttcaacaagattggaatagtggttgatgat 660 ggtctcaccgagcagggtgcaaaacgcattgttcccgttggtcttggagacgacgatcaa 720 tcaattgaagacgatttttcggcatggaaagagttagtgtggcccgaattggatctattg 780 cttcgcgatgaagatgacaaagctgctgcaactccttacacagctgcaatccctgaatac 840 cgcgtcgtatttcatgacaaacccgatgcgttttctgatgatcatactcaaaccaatggt 900 catgctgttcatgatgctcaacatccatgcagatccaatgtggctgttaaaaaagagctt 960 catactcctgaatccgatcgttcatgcacacatcttgaatttgacatttctcacactgga 1020 ttatcttatgaaactggggatcatgttggtgtatactgtgaaaacctaattgaagtagtg 1080 gaagaagctgggaaattgttaggattatcaacagatacttatttctcgttacatattgat 1140 aacgaagatggttcaccacttggtggaccttcattacaacctccttttcctccttgtact 1200 ttaagaaaagcattgactaattatgcagatctgttaagctctcccaaaaagtcaactttg 1260 cttgctctagctgctcatgcttccgatcccactgaagctgatcgtttaagatttcttgca 1320 tctcgcgagggcaaggatgaatatgctgaatgggttgttgcaaaccaaagaagtcttctt 1380 gaagtcatggaagctttcccgtcagctagaccgccacttggtgttttctttgcagcggtt 1440 gcaccgcgtttacagcctcgttactactctatttcttcctccccaaagatggaaccaaac 1500 aggattcatgttacttgcgcgttggtttatgaaaaaactcccgcaggtcgtatccacaaa 1560 ggaatctgctcaacctggatgaagaacgctgtacctttgaccgaaagtcaagattgcagt 1620 tgggcaccgatttttgttagaacatcaaacttcagacttccaattgacccgaaagtcccg 1680 gttatcatgattggtcctggaaccgggttggctccatttaggggttttcttcaagaaaga 1740 ttggctcttaaagaatccggaaccgaactcgggtcatctattttattcttcggttgtaga 1800 aaccgcaaagtggattacatatatgagaatgaactcaacaactttgttgaaaatggtgcg 1860 ctttctgagcttgatgttgctttctcccgcgatggcccgacgaaagaatacgtgcaacat 1920 aaaatgacccaaaaggcttctgaaatatggaatatgctttctgagggagcatatttatat 1980 gtatgtggtgatgctaaaggcatggctaaagatgtacaccgtacacttcacaccattgtg 2040 caagaacagggaagtttggactcgtctaaagcggagttgtatgtgaagaatctacaaatg 2100 tcaggaagatacctccgtgatgtttggtaa 2130 SEQIDNO:289 MQSESVEASTIDLMTAVLKDTVIDTANASDNGDSKMPPALAMMFEIRDLLLILTTSVAVL 60 VGCFVVLVWKRSSGKKSGKELEPPKIVVPKRRLEQEVDDGKKKVTIFFGTQTGTAEGFAK 120 ALFEEAKARYEKAAFKVIDLDDYAADLDEYAEKLKKETYAFFFLATYGDGEPTDNAAKFY 180 KWFTEGDEKGVWLQKLQYGVFGLGNRQYEHFNKIGIVVDDGLTEQGAKRIVPVGLGDDDQ 240 SIEDDFSAWKELVWPELDLLLRDEDDKAAATPYTAAIPEYRVVFHDKPDAFSDDHTQTNG 300 HAVHDAQHPCRSNVAVKKELHTPESDRSCTHLEFDISHTGLSYETGDHVGVYCENLIEVV 360 EEAGKLLGLSTDTYFSLHIDNEDGSPLGGPSLQPPFPPCTLRKALTNYADLLSSPKKSTL 420 LALAAHASDPTEADRLRFLASREGKDEYAEWVVANQRSLLEVMEAFPSARPPLGVFFAAV 480 APRLQPRYYSISSSPKMEPNRIHVTCALVYEKTPAGRIHKGICSTWMKNAVPLTESQDCS 540 WAPIFVRTSNFRLPIDPKVPVIMIGPGTGLAPFRGFLQERLALKESGTELGSSILFFGCR 600 NRKVDYIYENELNNFVENGALSELDVAFSRDGPTKEYVQHKMTQKASEIWNMLSEGAYLY 660 VCGDAKGMAKDVHRTLHTIVQEQGSLDSSKAELYVKNLQMSGRYLRDVW 709 SEQIDNO:290 atgtcctccaactccgatttggtcagaagattggaatctgttttgggtgtttctttcggt 60 ggttctgttactgattccgttgttgttattgctaccacctctattgctttggttatcggt 120 gttttggttttgttgtggagaagatcctctgacagatctagagaagttaagcaattggct 180 gttccaaagccagttactatcgttgaagaagaagatgaattcgaagttgcttctggtaag 240 accagagtttctattttctacggtactcaaactggtactgctgaaggttttgctaaggct 300 ttggctgaagaaatcaaagccagatacgaaaaagctgccgttaaggttattgatttggat 360 gattacacagccgaagatgacaaatacggtgaaaagttgaagaaagaaactatggccttc 420 ttcatgttggctacttatggtgatggtgaacctactgataatgctgctagattttacaag 480 tggttcaccgaaggtactgatagaggtgtttggttggaacatttgagatacggtgtattc 540 ggtttgggtaacagacaatacgaacacttcaacaagattgccaaggttgttgatgatttg 600 ttggttgaacaaggtgccaagagattggttactgttggtttgggtgatgatgatcaatgc 660 atcgaagatgatttctccgcttggaaagaagccttgtggccagaattggatcaattattg 720 caagatgataccaacaccgtttctactccatacactgctgttattccagaatacagagtt 780 gttatccacgatccatctgttacctcttatgaagatccatactctaacatggctaacggt 840 aatgcctcttacgatattcatcatccatgtagagctaacgttgccgtccaaaaagaattg 900 cataagccagaatctgacagaagttgcatccatttggaattcgatattttcgctactggt 960 ttgacttacgaaaccggtgatcatgttggtgtttacgctgataattgtgatgatactgta 1020 gaagaagccgctaagttgttgggtcaaccattggatttgttgttctccattcataccgat 1080 aacaacgacggtacttctttgggttcttctttgccaccaccatttccaggtccatgtact 1140 ttgagaactgctttggctagatatgccgatttgttgaatccaccaaaaaaggctgctttg 1200 attgctttagctgctcatgctgatgaaccatctgaagctgaaagattgaagttcttgtca 1260 tctccacaaggtaaggacgaatattctaaatgggttgtcggttcccaaagatccttggtt 1320 gaagttatggctgaatttccatctgctaaaccaccattgggtgtattttttgctgctgtt 1380 gttcctagattgcaacctagatattactccatctcttccagtccaagatttgctccacat 1440 agagttcatgttacttgcgctttggtttatggtccaactccaactggtagaattcacaga 1500 ggtgtatgttcattctggatgaagaatgttgtcccattggaaaagtctcaaaactgttct 1560 tgggccccaattttcatcagacaatctaatttcaagttgccagccgatcattctgttcca 1620 atagttatggttggtccaggtactggtttagctccttttagaggtttcttacaagaaaga 1680 ttggccttgaaagaagaaggtgctcaagttggtcctgctttgttgttttttggttgcaga 1740 aacagacaaatggacttcatctacgaagtcgaattgaacaactttgtcgaacaaggtgct 1800 ttgtccgaattgatcgttgctttttcaagagaaggtccatccaaagaatacgtccaacat 1860 aagatggttgaaaaggcagcttacatgtggaacttgatttctcaaggtggttacttctac 1920 gtttgtggtgatgctaaaggtatggctagagatgttcatagaacattgcataccatcgtc 1980 caacaagaagaaaaggttgattctaccaaggccgaatccatcgttaagaaattgcaaatg 2040 gacggtagatacttgagagatgtttggtga 2070 SEQIDNO:291 MSSNSDLVRRLESVLGVSFGGSVTDSVVVIATTSIALVIGVLVLLWRRSSDRSREVKQLA 60 VPKPVTIVEEEDEFEVASGKTRVSIFYGTQTGTAEGFAKALAEEIKARYEKAAVKVIDLD 120 DYTAEDDKYGEKLKKETMAFFMLATYGDGEPTDNAARFYKWFTEGTDRGVWLEHLRYGVF 180 GLGNRQYEHFNKIAKVVDDLLVEQGAKRLVTVGLGDDDQCIEDDFSAWKEALWPELDQLL 240 QDDTNTVSTPYTAVIPEYRVVIHDPSVTSYEDPYSNMANGNASYDIHHPCRANVAVQKEL 300 HKPESDRSCIHLEFDIFATGLTYETGDHVGVYADNCDDTVEEAAKLLGQPLDLLFSIHTD 360 NNDGTSLGSSLPPPFPGPCTLRTALARYADLLNPPKKAALIALAAHADEPSEAERLKFLS 420 SPQGKDEYSKWVVGSQRSLVEVMAEFPSAKPPLGVFFAAVVPRLQPRYYSISSSPRFAPH 480 RVHVTCALVYGPTPTGRIHRGVCSFWMKNVVPLEKSQNCSWAPIFIRQSNFKLPADHSVP 540 IVMVGPGTGLAPFRGFLQERLALKEEGAQVGPALLFFGCRNRQMDFIYEVELNNFVEQGA 600 LSELIVAFSREGPSKEYVQHKMVEKAAYMWNLISQGGYFYVCGDAKGMARDVHRTLHTIV 660 QQEEKVDSTKAESIVKKLQMDGRYLRDVW 689 SEQIDNO:292 atgacttctgcactttatgcctccgatcttttcaaacaattgaaaagtatcatgggaacg 60 gattctttgtccgatgatgttgtattagttattgctacaacttctctggcactggttgct 120 ggtttcgttgtcttattgtggaaaaagaccacggcagatcgttccggcgagctaaagcca 180 ctaatgatccctaagtctctgatggcgaaagatgaggatgatgacttagatctaggttct 240 ggaaaaacgagagtctctatcttcttcggcacacaaaccggaacagccgaaggattcgct 300 aaagcactttcagaagagatcaaagcaagatacgaaaaggcggctgtaaaagtaatcgat 360 ttggatgattacgctgccgatgatgaccaatatgaggaaaagttgaaaaaggaaacattg 420 gctttcttttgtgtagccacgtatggtgatggtgaaccaaccgataacgccgcaagattc 480 tacaagtggtttactgaagagaacgaaagagatatcaagttgcagcaacttgcttacggc 540 gtttttgccttaggtaacagacaatacgagcactttaacaagataggtattgtcttagat 600 gaagagttatgcaaaaagggtgcgaagagattgattgaagtcggtttaggagatgatgat 660 caatctatcgaggatgactttaatgcatggaaggaatctttgtggtctgaattagataag 720 ttacttaaggacgaagatgataaatccgttgccactccatacacagccgtcattccagaa 780 tatagagtagttactcatgatccaagattcacaacacagaaatcaatggaaagtaatgtg 840 gctaatggtaatactaccatcgatattcatcatccatgtagagtagacgttgcagttcaa 900 aaggaattgcacactcatgaatcagacagatcttgcatacatcttgaatttgatatatca 960 cgtactggtatcacttacgaaacaggtgatcacgtgggtgtctacgctgaaaaccatgtt 1020 gaaattgtagaggaagctggaaagttgttgggccatagtttagatcttgttttctcaatt 1080 catgccgataaagaggatggctcaccactagaaagtgcagtgcctccaccatttccagga 1140 ccatgcaccctaggtaccggtttagctcgttacgcggatctgttaaatcctccacgtaaa 1200 tcagctctagtggccttggctgcgtacgccacagaaccttctgaggcagaaaaactgaaa 1260 catctaacttcaccagatggtaaggatgaatactcacaatggatagtagctagtcaacgt 1320 tctttactagaagttatggctgctttcccatccgctaaacctcctttgggtgttttcttc 1380 gccgcaatagcgcctagactgcaaccaagatactattcaatttcatcctcacctagactg 1440 gcaccatcaagagttcatgtcacatccgctttagtgtacggtccaactcctactggtaga 1500 atccataagggcgtttgttcaacatggatgaaaaacgcggttccagcagagaagtctcac 1560 gaatgttctggtgctccaatctttatcagagcctccaacttcaaactgccttccaatcct 1620 tctactcctattgtcatggtcggtcctggtacaggtcttgctccattcagaggtttctta 1680 caagagagaatggccttaaaggaggatggtgaagagttgggatcttctttgttgtttttc 1740 ggctgtagaaacagacaaatggatttcatctacgaagatgaactgaataactttgtagat 1800 caaggagttatttcagagttgataatggctttttctagagaaggtgctcagaaggagtac 1860 gtccaacacaaaatgatggaaaaggccgcacaagtttgggacttaatcaaagaggaaggc 1920 tatctatatgtctgtggtgatgcaaagggtatggcaagagatgttcacagaacacttcat 1980 actatagtccaggaacaggaaggcgttagttcttctgaagcggaagcaattgtgaaaaag 2040 ttacaaacagagggaagatacttgagagatgtgtggtaa 2079 SEQIDNO:293 MTSALYASDLFKQLKSIMGTDSLSDDVVLVIATTSLALVAGFVVLLWKKTTADRSGELKP 60 LMIPKSLMAKDEDDDLDLGSGKTRVSIFFGTQTGTAEGFAKALSEEIKARYEKAAVKVID 120 LDDYAADDDQYEEKLKKETLAFFCVATYGDGEPTDNAARFYKWFTEENERDIKLQQLAYG 180 VFALGNRQYEHFNKIGIVLDEELCKKGAKRLIEVGLGDDDQSIEDDFNAWKESLWSELDK 240 LLKDEDDKSVATPYTAVIPEYRVVTHDPRFTTQKSMESNVANGNTTIDIHHPCRVDVAVQ 300 KELHTHESDRSCIHLEFDISRTGITYETGDHVGVYAENHVEIVEEAGKLLGHSLDLVFSI 360 HADKEDGSPLESAVPPPFPGPCTLGTGLARYADLLNPPRKSALVALAAYATEPSEAEKLK 420 HLTSPDGKDEYSQWIVASQRSLLEVMAAFPSAKPPLGVFFAAIAPRLQPRYYSISSSPRL 480 APSRVHVTSALVYGPTPTGRIHKGVCSTWMKNAVPAEKSHECSGAPIFIRASNFKLPSNP 540 STPIVMVGPGTGLAPFRGFLQERMALKEDGEELGSSLLFFGCRNRQMDFIYEDELNNFVD 600 QGVISELIMAFSREGAQKEYVQHKMMEKAAQVWDLIKEEGYLYVCGDAKGMARDVHRTLH 660 TIVQEQEGVSSSEAEAIVKKLQTEGRYLRDVW 692 SEQIDNO:294 atggaagtaacagtagctagtagtgtagccctgagcctggtctttattagcatagtagta 60 agatgggcatggagtgtggtgaattgggtgtggtttaagccgaagaagctggaaagattt 120 ttgagggagcaaggccttaaaggcaattcctacaggtttttatatggagacatgaaggag 180 aactctatcctgctcaaacaagcaagatccaaacccatgaacctctccacctcccatgac 240 atagcacctcaagtcaccccttttgtcgaccaaaccgtgaaagcttacggtaagaactct 300 tttaattgggttggccccataccaagggtgaacataatgaatccagaagatttgaaggac 360 gtcttaacaaaaaatgttgactttgttaagccaatatcaaacccacttatcaagttgcta 420 gctacaggtattgcaatctatgaaggtgagaaatggactaaacacagaaggattatcaac 480 ccaacattccattcggagaggctaaagcgtatgttaccttcatttcaccaaagttgtaat 540 gagatggtcaaggaatgggagagcttggtgtcaaaagagggttcatcatgtgagttggat 600 gtctggccttttcttgaaaatatgtcggcagatgtgatctcgagaacagcatttggaact 660 agctacaaaaaaggacagaaaatctttgaactcttgagagagcaagtaatatatgtaacg 720 aaaggctttcaaagtttttacattccaggatggaggtttctcccaactaagatgaacaag 780 aggatgaatgagattaacgaagaaataaaaggattaatcaggggtattataattgacaga 840 gagcaaatcattaaggcaggtgaagaaaccaacgatgacttattaggtgcacttatggag 900 tcaaacttgaaggacattcgggaacatgggaaaaacaacaaaaatgttgggatgagtatt 960 gaagatgtaattcaggagtgtaagctgttttactttgctgggcaagaaaccacttcagtg 1020 ttgctggcttggacaatggttttacttggtcaaaatcagaactggcaagatcgagcaaga 1080 caagaggttttgcaagtctttggaagcagcaagccagattttgatggtctagctcacctt 1140 aaagtcgtaaccatgattttgcttgaagttcttcgattatacccaccagtcattgaactt 1200 attcgaaccattcacaagaaaacacaacttgggaagctctcactaccagaaggagttgaa 1260 gtccgcttaccaacactgctcattcaccatgacaaggaactgtggggtgatgatgcaaac 1320 cagttcaatccagagaggttttcggaaggagtttccaaagcaacaaagaaccgactctca 1380 ttcttccccttcggagccggtccacgcatttgcattggacagaacttttctatgatggaa 1440 gcaaagttggccttagcattgatcttgcaacacttcacctttgagctttctccatctcat 1500 gcacatgctccttcccatcgtataacccttcaaccacagtatggtgttcgtatcatttta 1560 catcgacgttag 1572 SEQIDNO:295 atggaagtcactgtcgcctcttctgtcgctttatccttagtcttcatttccattgtcgtc 60 agatgggcttggtccgttgtcaactgggtttggttcaaaccaaagaagttggaaagattc 120 ttgagagagcaaggtttgaagggtaattcttatagattcttgtacggtgacatgaaggaa 180 aattctattttgttgaagcaagccagatccaaaccaatgaacttgtctacctctcatgat 240 attgctccacaagttactccattcgtcgatcaaactgttaaagcctacggtaagaactct 300 ttcaattgggttggtccaattcctagagttaacatcatgaacccagaagatttgaaggat 360 gtcttgaccaagaacgttgacttcgttaagccaatttccaacccattgattaaattgttg 420 gctactggtattgccatttacgaaggtgaaaagtggactaagcatagaagaatcatcaac 480 cctaccttccactctgaaagattgaagagaatgttaccatctttccatcaatcctgtaat 540 gaaatggttaaggaatgggaatccttggtttctaaagaaggttcttcttgcgaattggat 600 gtttggccattcttggaaaatatgtctgctgatgtcatttccagaaccgctttcggtacc 660 tcctacaagaagggtcaaaagattttcgaattgttgagagagcaagttatttacgttacc 720 aagggtttccaatccttctacatcccaggttggagattcttgccaactaaaatgaacaag 780 cgtatgaacgagatcaacgaagaaattaaaggtttgatcagaggtattattatcgacaga 840 gaacaaattattaaagctggtgaagaaaccaacgatgatttgttgggtgctttgatggag 900 tccaacttgaaggatattagagaacatggtaagaacaacaagaatgttggtatgtctatt 960 gaagatgttattcaagaatgtaagttattctacttcgctggtcaagagaccacttctgtt 1020 ttgttagcctggactatggtcttgttaggtcaaaaccaaaattggcaagatagagctaga 1080 caagaagttttgcaagtcttcggttcttccaagccagactttgatggtttggcccacttg 1140 aaggttgttactatgattttgttagaagttttgagattgtacccaccagtcattgagtta 1200 atcagaaccattcataaaaagactcaattgggtaaattatctttgccagaaggtgttgaa 1260 gtcagattaccaaccttgttgattcaccacgataaggaattatggggtgacgacgctaat 1320 caatttaatccagaaagattttccgaaggtgtttccaaggctaccaaaaaccgtttgtcc 1380 ttcttcccatttggtgctggtccacgtatttgtatcggtcaaaacttttccatgatggaa 1440 gccaagttggctttggctttaatcttgcaacacttcactttcgaattgtctccatcccat 1500 gcccacgctccttctcatagaatcactttacaaccacaatacggtgtcagaatcatctta 1560 cacagaagataa 1572
(161) Having described the invention in detail and by reference to specific embodiments thereof, it will be apparent that modifications and variations are possible without departing from the scope of the invention defined in the appended claims. More specifically, although some aspects of the present invention are identified herein as particularly advantageous, it is contemplated that the present invention is not necessarily limited to these particular aspects of the invention.