FLAVORED VAPORIZABLE FORMULATION

Abstract

There is provided a flavored vaporizable formulation comprising (i) one or more solvents; (ii) a flavor; and (iii) one or more cyclodextrins; wherein the flavored vaporizable formulation contains water in an amount of from 0 to 10 wt. % based on the vaporizable formulation.

Claims

1. A flavored vaporizable formulation comprising: (i) one or more solvents; (ii) a flavor; and (iii) one or more cyclodextrins; wherein the flavored vaporizable formulation contains water in an amount of from 0 to 10 wt. % based on the vaporizable formulation; wherein the flavored vaporizable formulation further comprises nicotine.

2. A flavored vaporizable formulation according to claim 1 wherein the total content of cyclodextrins is at least 1 wt. % based on the vaporizable formulation.

3. A flavored vaporizable formulation according to claim 1 wherein the one or more cyclodextrins are selected from the group consisting of substituted or unsubstituted ()-cyclodextrin, substituted or unsubstituted ()-cyclodextrin, substituted or unsubstituted ()-cyclodextrin, and mixtures thereof.

4. A flavored vaporizable formulation according to claim 1 wherein the one or more cyclodextrins comprises at least one or more substituted cyclodextrins.

5. A flavored vaporizable formulation according to claim 1 wherein the solvent is selected from water, glycerol, propylene glycol and mixtures thereof.

6. A flavored vaporizable formulation according to claim 1 wherein the solvent comprises at least glycerol, propylene glycol or a mixture thereof.

7. A flavored vaporizable formulation according to claim 1 wherein the solvent is mixture of glycerol and propylene glycol.

8. A flavored vaporizable formulation according to claim 1 wherein the flavored vaporizable formulation contains water in an amount of from 0 to 5 wt. % based on the vaporizable formulation.

9. A flavored vaporizable formulation according to claim 1 wherein the flavored vaporizable formulation contains water in an amount of from 0 to 1 wt. % based on the vaporizable formulation.

10. A flavored vaporizable formulation according to claim 1 wherein the flavored vaporizable formulation contains water in an amount of from 0 to 0.1 wt. % based on the vaporizable formulation.

11. A flavored vaporizable formulation according to claim 1 wherein the solvent is present in an amount of at least 75 wt. % based on the flavored vaporizable formulation.

12. A flavored vaporizable formulation according to claim 1 wherein the solvent is present in an amount of at least 90 wt. % based on the flavored vaporizable formulation.

13. A flavored vaporizable formulation according to claim 1 wherein the one or more flavors are selected from the group consisting of (4-(para-)methoxyphenyl)-2-butanone, vanillin, -undecalactone, menthone, 5-propenyl guaethol, menthol, para-mentha-8-thiol-3-one and mixtures thereof.

14. A flavored vaporizable formulation according to claim 1 wherein the flavor includes menthol.

15. A flavored vaporizable formulation according to claim 1 wherein the one or more flavors are present in a total amount of no greater than 2 wt. % based on the flavored vaporizable formulation.

16. A flavored vaporizable formulation according to claim 1 wherein the one or more flavors are present in a total amount of from 0.01 to 1 wt. % based on the flavored vaporizable formulation.

17. A flavored vaporizable formulation according to claim 1 wherein the one or more cyclodextrins are selected from the group consisting of substituted ()-cyclodextrin, substituted ()-cyclodextrin, substituted ()-cyclodextrin, and mixtures thereof.

18. A flavored vaporizable formulation according to claim 1 wherein the one or more cyclodextrins is at least 2-hydroxy-propyl--cyclodextrin.

19. A flavored vaporizable formulation according to claim 1 wherein the one or more cyclodextrins are present in a total amount of at least 7 wt. % based on the flavored vaporizable formulation.

20. A flavored vaporizable formulation according to claim 1 wherein the one or more cyclodextrins are present in a total amount of no greater than 10 wt. % based on the flavored vaporizable formulation.

21. A flavored vaporizable formulation according to claim 1 wherein the one or more cyclodextrins are present in a total amount of from 2 to 9 wt. % based on the flavored vaporizable formulation.

22. A process for forming a vapor, the process comprising: (a) providing a flavored vaporizable formulation as defined in claim 1; and (b) vaporizing the flavored vaporizable formulation.

23. A contained flavored vaporizable formulation comprising (a) a container; and (b) a flavored vaporizable formulation as defined in claim 1.

24. An electronic vapor provision system comprising: (a) a vaporizer for vaporizing liquid for inhalation by a user of the electronic vapor provision system; (b) a power supply comprising a cell or battery for supplying power to the vaporizer; and (c) a flavored vaporizable formulation comprising: (i) one or more solvents; (ii) a flavor; and (iii) one or more cyclodextrins; wherein the flavored vaporizable formulation contains water in an amount of from 0 to 10 wt. % based on the vaporizable formulation.

25. An electronic vapour provision system according to claim 24 wherein the flavored vaporizable formulation is a flavored vaporizable formulation having a total content of cyclodextrins of at least 1 wt. % based on the vaporizable formulation.

26. A process for at least one of increasing solubility of a flavor and/or reducing loss of flavor over time during storage from a flavored vaporizable formulation, the process comprising: (a) providing a vaporizable material comprising at least one or more solvents; (b) incorporating into the vaporizable material a flavor and one or more cyclodextrins to form the flavored vaporizable formulation.

27. A process according to claim 26 wherein the flavored vaporizable formulation is a flavored vaporizable formulation comprising: (i) one or more solvents; (ii) a flavor; and (iii) one or more cyclodextrins; wherein the flavored vaporizable formulation contains water in an amount of from 0 to 10 wt. % based on the vaporizable formulation; wherein the flavored vaporizable formulation further comprises nicotine.

28. Use of one or more cyclodextrins for increasing solubility of a flavor and/or reducing loss of flavor over time during storage from a flavored vaporizable formulation, wherein the flavored vaporizable formulation comprises: (i) one or more solvents; and (ii) a flavor.

29. Use according to claim 28 wherein the flavored vaporizable formulation is a flavored vaporizable comprising: (i) one or more solvents; (ii) a flavor; and (iii) one or more cyclodextrins; wherein the flavored vaporizable formulation contains water in an amount of from 0 to 10 wt. % based on the vaporizable formulation; wherein the flavored vaporizable formulation further comprises nicotine.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0118] Embodiments disclosed herein will now be described in further detail by way of example only with reference to the accompanying figure in which:

[0119] FIG. 1 shows a graph;

[0120] FIG. 2 shows a graph;

[0121] FIG. 3 shows a schematic of an analysis method;

[0122] FIG. 4 shows a spectra;

[0123] FIG. 5 shows a spectra; and

[0124] FIG. 6 shows a graph;

[0125] An embodiment of the invention will now be described with reference to the following non-limiting example.

Examples

[0126] Base Formulation

[0127] Base Formulation 1 was prepared containing:

TABLE-US-00001 propylene glycol 35.5 wt. % glycerol 39.5 wt. % water 25 wt. %

[0128] Into this base formulation was incorporated a variety of 2-hydroxy-propyl--cyclodextrin (HP-B-CD) and menthol amounts as described below: [0129] Excess of menthol added to base formulation containing varying concentrations of HP-B-CD [0130] Formulation allowed to equilibrate for 24 hrs on roller. [0131] Excess menthol centrifuged then filtered off by syringe filtration (Millex PVDF, 0.45 m pore size) [0132] Saturated formulation isolated and diluted in PES. [0133] Diluted formulation analyzed via GC-FID to quantify maximum menthol concentration in formulation. [0134] Plotting maximum menthol concentration at each HP-B-CD concentration gives a gradient which shows how effective cyclodextrin is at solubilizing menthol in that base formulation. [0135] 3 repeats at each cyclodextrin concentration.

[0136] Visual Inspection

[0137] The products were subjected to visual inspection and the results given below. Solubilization was considered to have occurred when substantially no menthol crystals could be visualized. Where the menthol crystals were considered to have solubilized the sample was given a Y (yes, solubilized). Where the menthol crystals were considered to have solubilized the sample was given a N (no, not solubilized).

TABLE-US-00002 Menthol Cyclodextrin Concentration (% w/w) Concentration N/A 0.5 1 3 7 0.50% Y Y Y Y Y 0.60% N N N Y Y 0.70% N N N Y Y 0.80% N N N N Y 0.90% N N N N Y 1% N N N N Y

[0138] Phase Solubility

[0139] Phase solubility was also studied and the results of this are shown in FIGS. 1 and 2.

[0140] These analytical data support the solubility trend seen observationally in formulations i.e. menthol concentration is increased with increasing cyclodextrin concentration. A linear relationship of increased menthol concentration when increasing HP-B-CD concentration was observed. Approximately 30% increase in menthol concentration was found from 0% HP-B-CD to 3% HP-B-CD.

[0141] Static Headspace

[0142] In addition to Base Formulation 1 (described above), Base Formulation 2 was prepared containing:

TABLE-US-00003 propylene glycol 40 wt. % glycerol 60 wt. %

[0143] Base Formulation 1 and Base Formulation 2 containing 0%, 3% and 20% w/w HP-B-CD were prepared. 10 g of each base formulations were spiked with 0.05 g menthol. and 0.4 g of a flavor comprising essential oils 1 mL headspace of volatile compounds was analyzed to study whether cyclodextrins reduce the volatility of flavor compounds and thereby reduce flavor loss from cartomiser units. The method of analysis is shown in FIG. 3. The concentrations of HPBCD used (w/w) were 0%, 0.5%, 1%, 3% and 7% and the following procedure was followed: [0144] Cartomiser units filled with e-liquid containing varying concentrations of cyclodextrin. [0145] Measurement of menthol concentration via GC-FID every two weeks in order to track menthol loss from cartomisers over time and to see if this is influenced by the presence of cyclodextrin. [0146] 0.1 mL taken from cartomiser at each time point (two measurement at each concentration) [0147] Cartomisers kept at room temperature

[0148] The results of the analysis are shown in FIGS. 4, 5 and 6. The headspace analysis showed that the presence of cyclodextrin reduces the concentration of flavor compounds in the headspace. The reduction of headspace loss was observed for both bases. The cartomiser loss also confirmed that cyclodextrin reduces the loss of menthol from cartomisers.

[0149] Various modifications and variations of the present invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention which are obvious to those skilled in chemistry or related fields are intended to be within the scope of the following claims.