CHROMATOGRAPHY SYSTEM

Abstract

Provided is a chromatography system including a usage information storage device, a column usage information holding part, and a usage information managing part. The usage information storage device is provided corresponding to the analytical column incorporated in the chromatography system and is configured to keep usage information for each corresponding analytical column. The column usage information holding part is provided separately from the analytical column and is configured to keep usage information for each of the analytical columns which may be incorporated in the chromatography system. The usage information managing part is configured to update, at a timing when an analysis process of separating a sample injected into the analysis channel using the analytical column is executed, the usage information kept by the usage information storage device and the usage information kept by the column usage information holding part in association with the analytical column to latest usage information.

Claims

1. A chromatography system which includes an analysis channel in which an analytical column is incorporated, and is configured so that a sample injected into the analysis channel is separated in the analytical column, the chromatography system comprising; a usage information storage device provided corresponding to the analytical column incorporated in the chromatography system, and configured to keep usage information for the analytical column; a column usage information holding part provided separately from the analytical column and configured to keep usage information for each analytical column which may be incorporated in the chromatography system; and a usage information managing part configured to update, at a timing when an analysis process of separating a sample injected into the analysis channel using the analytical column is executed, the usage information kept by the usage information storage device and the usage information kept by the column usage information holding part in association with the analytical column to latest usage information.

2. The chromatography system according to claim 1, wherein the usage information managing part is configured to create, at the timing when the analysis process of separating a sample injected into the analysis channel using the analytical column is executed, the latest usage information using the usage information already kept by the usage information storage device and usage information resulted from a result of the analysis process, and to cause the usage information storage device and the column usage information holding part to keep the latest usage information.

3. The chromatography system according to claim 1, further comprising: a usage information restoring part configured to cause the usage information storage device provided corresponding to the analytical column incorporated in the chromatography system to keep the latest usage information for the analytical column, using the usage information for the analytical column kept in the column usage information holding part.

4. The chromatography system according to claim 3, wherein the usage information restoring part is configured to cause the usage information storage device to keep usage information for the analytical column selected from among the analytical columns for which usage information is kept in the column usage information holding part based on a user operation.

5. The chromatography system according to claim 3, wherein if the usage information storage device provided corresponding to the analytical column incorporated in the chromatography system keeps no usage information for the analytical column, the usage information restoring part is configured to cause the usage information storage device to keep the usage information for the analytical column kept in the column usage information holding part.

6. The chromatography system according to claim 1, further comprising: a damage notifying part configured to execute a damage notification operation of notifying a user that usage information is unable to be read out if the usage information is unable to be read out from the usage information storage device provided corresponding to the analytical column incorporated in the chromatography system.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0015] FIG. 1 is a block diagram schematically illustrating a chromatography system according to an embodiment.

[0016] FIG. 2 is a flowchart for illustrating an example of operation of updating usage information and operation of notifying damage to an analytical column according to the embodiment.

[0017] FIG. 3 is a flowchart for illustrating an example of restoring operation of usage information according to the embodiment.

EMBODIMENT OF THE INVENTION

[0018] Hereinafter, a chromatography system according to an embodiment of the present invention will be described with reference to the drawings. Although a liquid chromatography system will be described below as an example of the chromatography system, the present invention can also be similarly applied to a supercritical fluid chromatography system and a gas chromatography system.

[0019] A liquid chromatography system 1 includes a liquid feeding device 2, an autosampler 4, a column oven 6, a detector 8, and a system management device 10. The liquid feeding device 2, the autosampler 4, the column oven 6, and the detector 8 are connected in series with pipes to constitute an analysis channel for performing liquid chromatography analysis.

[0020] The liquid feeding device 2 is configured to feed a mobile phase in the analysis channel. The autosampler 4 is configured to inject a sample into the analysis channel in which the mobile phase from the liquid feeding device 2 flows. The column oven 6 is configured to adjust temperature of an analytical column housed therein to a predetermined temperature. The analytical column 12 housed in the column oven 6 is connected to a downstream side of the autosampler 4. The detector 8 is connected to a downstream side of the analytical column 12 housed in the column oven 6 and is configured to detect sample components separated in the analytical column 12.

[0021] A memory element 12a is provided corresponding to the analytical column 12. Examples of providing the memory element 12a corresponding to the analytical column 12 include the memory element 12a is built in the analytical column 12, the memory element 12a is attached to the outside of the analytical column 12, and the memory element 12a is provided completely separated from the analytical column 12. The memory element 12a is configured to keep usage information such as cumulative usage time of the analytical column 12, a cumulative frequency of usage thereof, and a last usage date and time, together with identification information for the analytical column 12, and serves as a usage information storage device for holding usage information for the analytical column 12. The memory element 12a provided corresponding to the analytical column 12 is connected to a control part 14 mounted in the column oven 6, being electrically communicable with each other when the analytical column 12 is housed in the column oven 6 and incorporated in the chromatography system 1. The control part is, for example, an electronic circuit board having a function of controlling operation of a heater or a fan provided for adjusting temperature inside the column oven 6.

[0022] The system management device 10 is configured to perform electrical communication with each of the liquid feeding device 2, the autosampler 4, the column oven 6, and the detector 8 to perform overall operation management of the liquid chromatography system 1. The system management device 10 is implemented by, for example, a dedicated computer or a general-purpose personal computer.

[0023] The system management device 10 has a function of communicating information to the memory element 12a of the analytical column 12 incorporated in the liquid chromatography system 1 using the control part 14 to manage usage of the analytical column 12. As functions of managing the analytical column 12, the system management device 10 includes a usage information managing part 16, a column usage information holding part 18, a usage information restoring part 20, and a damage notifying part 22. The usage information managing part 16, the usage information restoring part 20, and the damage notifying part 22 each have a function obtained by allowing an arithmetic element such as a microcomputer to execute a predetermined program. The column usage information holding part 18 has a function implemented by a partial storage area of a storage device provided in the system management device 10.

[0024] The usage information managing part 16 is configured to perform update operation of usage information in the memory element 12a and the column usage information holding part 18 so that the latest usage information for the analytical column 12 is kept in both the memory element 12a and the column usage information holding part 18. Specifically, the usage information managing part 16 reads out the usage information for the analytical column 12 from the memory element 12a of the analytical column 12 before the liquid chromatography analysis is started, and updates the usage information after the analysis is completed, based on the usage information before the liquid chromatography analysis is started. Then, the latest usage information updated using the control part 14 is written into the memory element 12a, and the same latest usage information is also written into the column usage information holding part 18.

[0025] As described above, one analytical column 12 maybe reused in a plurality of liquid chromatography systems 1. Even in such a case, the same update operation is performed in each liquid chromatography system 1, so that the latest usage information is always kept in the memory element 12a. Thus, when the analytical column 12 used in another liquid chromatography system 1 is incorporated in the liquid chromatography system 1, the usage information for the analytical column 12 is further updated based on the latest usage information kept in the memory element 12a provided corresponding to the analytical column 12 incorporated in the liquid chromatography system 1. The updated latest usage information is kept in the memory element 12a and the column usage information holding part 18. Thus, even when the same analytical column 12 is reused in a plurality of liquid chromatography systems 1, the column usage information holding part 18 of one of the liquid chromatography systems 1 keeps the latest usage information for the analytical column 12. This prevents the latest usage information from being lost even when the memory element 12a is damaged.

[0026] In addition, a plurality of types of analytical columns 12 may be selectively used in one liquid chromatography system 1 depending on a sample to be analyzed. For this case, the column usage information holding part 18 is configured to keep usage information for each analytical column 12 in association with identification information for each corresponding analytical column 12 (or identification information for the memory element 12a provided corresponding to each analytical column 12), so that the latest usage information for each analytical column 12 is kept in both the memory element 12a provided corresponding to each analytical column 12 and the column usage information holding part 18.

[0027] The usage information restoring part 20 is configured to execute restoring operation of writing usage information kept in the column usage information holding part 18 into the memory element 12a to restore the usage information to the memory element 12a. When the memory element 12a provided corresponding to the analytical column 12 is damaged, the memory element 12a is replaced with a new one. Thus, the usage information of the analytical column 12 is not kept in the memory element 12a. In such a case, using a function of restoring usage information of the usage information restoring part 20 enables holding the latest usage information for the analytical column 12 in the new memory element 12a.

[0028] The system management device 10 has a damage notifying function of detecting damage to the memory element 12a provided corresponding to the analytical column 12 to notify a user of the damage. The damage notifying function is implemented by the damage notifying part 22. The damage to the memory element 12a can be detected by determining whether information can be read out from the memory element 12a. The damage notifying part 22 is configured so that when the system management device 10 cannot normally perform communication (reading out information from the memory element 12a) with the memory element 12a, the user is notified of this fact. The notification may be performed, for example, by a method of displaying a warning on a display connected to the system management device 10 or by a method of emitting a warning sound.

[0029] The above operation of managing usage information and operation of notifying damage will be described with reference to the flowchart of FIG. 2 together with FIG. 1.

[0030] When the liquid chromatography system 1 that is incorporated with the analytical column 12 is activated, the system management device 10 attempts communication with the memory element 12a provided corresponding to the analytical column 12 (step S1). When the communication can be performed between the system management device 10 and the memory element 12a, the usage information managing part 16 reads out usage information from the memory element 12a (step S2). When the communication cannot be performed between the system management device 10 and the memory element 12a, the damage notifying part 22 notifies a user that the memory element 12a is damaged (step S6).

[0031] When the usage information managing part 16 can normally read out the usage information from the memory element 12a (step S2), liquid chromatography analysis is executed (step S3), and duration of the analysis and an end date and time thereof are recorded. The usage information managing part 16 updates the usage information read out from the memory element 12a using the recorded duration of the analysis and end date and time thereof (step S4). Specifically, for example, the duration of the analysis is added to cumulative usage time read out as one of the usage information from the memory element 12a to update the last usage date and time. The usage information managing part 16 writes the usage information for the analytical column 12 updated using the control part 14 into the memory element 12a, and further writes the same usage information into the column usage information holding part 18 while associating it with identification information for the analytical column 12 or identification information for the memory element 12a (step S5).

[0032] Next, the restoring operation of usage information to the memory element 12a will be described with reference to the flowchart of FIG. 3 together with FIG. 1.

[0033] The usage information restoring part 20 is configured to execute this restoring operation, for example, in response to a request from a user. The usage information restoring part 20 may be configured to automatically execute the restoring operation when recognizing that the latest usage information for the analytical column 12 is not kept in the memory element 12a.

[0034] When the restoring operation is executed, the usage information restoring part 20 displays a list of each analytical column 12 with usage information kept in the column usage information holding part 18 on a display connected to the system management device 10 to allow a user to select the analytical column 12 to be restored (step S11). The user may input identification information for the analytical column 12 to select the analytical column 12 to be restored.

[0035] When the user selects the analytical column 12 to be restored, the usage information restoring part 20 reads out the usage information for the analytical column 12 to be restored from the column usage information holding part 18 (step S12), and then writes the usage information into the memory element 12a (step S13). At this time, when the usage information for the analytical column 12 is kept in the column usage information holding part 18 while being associated with the identification information for the memory element 12a, the column usage information holding part 18 updates the identification information for the memory element 12a in associating with the usage information for the analytical column 12 to that on a new memory element 12a.

DESCRIPTION OF REFERENCE SIGNS

[0036] 1: Liquid chromatography system

[0037] 2: Liquid feeding device

[0038] 4: Autosampler

[0039] 6: Column oven

[0040] 8: Detector

[0041] 10: System management device

[0042] 12: Analytical column

[0043] 12a: Memory element (usage information storage device)

[0044] 14: Control part

[0045] 16: Usage information managing part

[0046] 18: Column usage information holding part

[0047] 20: Usage information restoring part

[0048] 22: Damage notifying part