Hydrophilic Lubricating Coating for Medical Catheters and Its Preparation Method

Abstract

The invention discloses a photocured medical catheter hydrophilic lubricating coating and a preparation method thereof. The hydrophilic lubricating coating comprises a primer coating and a lubricating coating. The primer coating is attached to the surface of a device, and the lubricating coating is attached to the primer coating. The primer coating comprises 1-10 parts by weight of one or more polyester acrylates, 50-90 parts by weight of one or more solvents, 0.5-5 parts by weight of one or more photoinitiators, 0.5-2 parts by weight of one or more wetting agents and 0.5-5 parts by weight of one or more reactive (or active) diluents. The lubricating coating comprises 1-10 parts by weight of one or more water soluble macromolecules, 1-5 parts by weight of one or more crosslinking (or crosslinked) macromolecules, 0-1 part by weight of one or more photoinitiators, 0.1-1 part by weight of one or more surfactants and 50-98 parts by weight of one or more solvents. The preparation method of the hydrophilic lubricating coating is simple and easy in operation. Substance residues caused by complicated high-temperature chemical reactions are avoided. The cured coating forms a crosslinking (or crosslinked) structure, has good adhesion on the surface of a medical catheter and has excellent and lasting lubricity in an aqueous medium. The friction coefficient of the surface of the medical catheter is reduced. Harm to human tissues and adhesion of macromolecules in blood are decreased.

Claims

1. A photocurable hydrophilic lubricating coating for medical catheter, comprising a primer coating attached to the device surface and the lubricating coating on the top of the primer coating, in which: The said primer coating includes the following parts by weight of components: polyester acrylate 1-10 parts, solvent 50-90 parts, photoinitiator 0.5-5 parts, wetting agent 0.5-2 parts and active diluent 0.5-5 parts. Compared with traditional urethane acrylate, polyester acrylate has good adhesion, while its high-density cross-linked network structure gives the coating good flexibility and suitable coating hardness, with 100% solid content, no pollution. Its good photosensitivity provides rapid curing of the coating, greatly improving production efficiency. The said lubricant top coating includes the following parts by weight of components: water-soluble macromolecules 1-10 parts, cross-linked macromolecules 1-5 parts, photoinitiator 0-1 part, surfactant 0.1-1 part and mixed solvent 50-98 parts.

2. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said polyester acrylate is a water-soluble resin.

3. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said polyester acrylate is an aliphatic resin.

4. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said polyester acrylate has an unsaturated functionality with one or more oligomers selected from 3 functional polyester acrylate, 4 functional polyester acrylate and 6-functionality polyester acrylate.

5. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said solvent is selected from ethyl alcohol, propanol or isopropyl alcohol.

6. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein photoinitiator of the said coating is one or more selected from 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone (IRGACURE 2959), 2-hydroxy-2-methylpropiophenone (DAROCUR 1173), benzophenone and methyl benzoylformate.

7. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said wetting agent is selected from polyether modified organosilicone or polyether modified organosiloxane.

8. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said reactive diluent is one or more of single-functional active diluent and multi-functional active diluent.

9. The photocurable hydrophilic lubricating coating for medical catheter as in claim 8, wherein said reactive diluent is one or more of vinylpyrrolidone, hydroxyethyl methacrylate, ethoxyethoxyethyl acrylate and propylene oxide neopentyl glycol diacrylate.

10. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said water-soluble macromolecules are selected from one or more of polyvinylpyrrolidone, polyethylene glycol, polyethylene oxide, and polyvinyl alcohol.

11. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said cross-linked macromolecules are water-soluble substances.

12. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said cross-linked macromolecules are oxygen-insensitive cross-linked substances, and has a light-absorbing functional group or a chromophore, and can self-luminously polymerize under UV light without adding a photoinitiator.

13. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said cross-linked macromolecule The cross-linked macromolecule are oxygen-sensitive substances, which can be polymerized under UV light by adding a small amount of photoinitiator.

14. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said cross-linked macromolecules are capable of cross-linking to form a network structure, which is both water-insoluble and water-swellable.

15. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said cross-linked macromolecules are selected from one or more of polyvinyl alcohol pyridines, waterborne polyurethane, trimethylolpropane triacrylate.

16. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said surfactant is a water-soluble nonionic surfactant, and is selected from one or more of polyethylene glycol and polyethylene oxide.

17. The photocurable hydrophilic lubricating coating for medical catheter as in claim 1, wherein said mixed solvent is a mixture of alcohol and water, wherein the alcohol solvent is selected from ethanol, propanol or isopropanol.

18. A preparation method of a hydrophilic lubricating coating for medical catheters according to any one of claims 1-17, it is characterized in the following steps: S1: Preparation of the primer coating: S11: Weigh each component by said parts of weight of the primer coating; S12: Add solvent, reactive diluent, photoinitiator and wetting agent into the polyester acrylate in sequence, and stir for 1-3 h in the dark to obtain the primer coating, which should be stored away from light; S2: Preparation of the lubricating coating: S21: Weigh each component by said parts of weight of the lubricating coating; S22: Add mixed solvent, cross-linked macromolecules, surfacant and photoinitiator into the water-soluble macromolecules in sequence, and stir for 1-3 h in the dark to obtain the lubricating coating, which should be stored away from light;

19. A method for using said photocurable hydrophilic lubricating coating according to any one of claims 1-17, it is characterized in the following steps: S31: Wipe the medical catheter to be treated with a clean cloth dipped in absolute ethanol to remove dirt on the surface and dry; S32: Uniformly apply said primer coating in claim 18 on the cleaned medical catheter by dipping, spraying or brushing, and cure the surface of the catheter under ultraviolet light to form a primer coating. S33: Uniformly apply said lubricating coating in claim 18 on the primer coating of medical catheter by dipping, spraying or brushing, and cure the surface of the catheter under ultraviolet light to form a hydrophilic lubricating coating.

Description

FIGURE

[0050] FIG. 1 is a curve chart of the frictional force test of the hydrophilic lubricating coatings for medical catheters in various embodiments of the present invention.

DETAILED DESCRIPTION

[0051] The present invention will be described in detail through following specific embodiments to deliver a better understanding of the present invention. However, the following embodiments do not limit the scope of the present invention.

Embodiment 1

[0052] Compositions of the primer coating: 2.0 g of 6-functional polyester acrylic resin, 0.4 g of hydroxyethyl methacrylate, 0.15 g of polyether-modified organosiloxane, 0.3 g of photoinitiator 2-hydroxy-2-methylphenylacetone, and 24 g of absolute ethanol are weighted and placed in a amber bottle, magnetically stirred for 2 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of the primer coating.

[0053] Compositions of the lubricating coating: 1.0 g of polyvinylpyrrolidone, 0.4 g of polyvinylpyridine, 0.2 g of polyethylene glycol, 0.1 g of polyoxyethylene, 12 g of water, and 31.3 g of absolute ethanol are weighed and placed in a amber bottle, magnetic stirred for 1-3 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of lubricating coating.

Embodiment 2

[0054] Compositions of the primer coating: 1.0 g of 3-functional polyester acrylic resin, 1.0 g of 6-functional polyester acrylic resin, 0.4 g of hydroxyethyl methacrylate, 0.15 g of polyether-modified organosiloxane, 0.3 g of photoinitiator 2-hydroxy-4-(2-hydroxyethoxy)-2-methylbenzeneacetone (IRGACURE 2959), and 24 g of absolute ethanol are weighted and placed in a amber bottle, magnetically stirred for 2 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of the primer coating.

[0055] Compositions of the lubricating coating: 1.0 g of polyvinylpyrrolidone, 0.4 g of polyvinylpyridine, 0.2 g of polyethylene glycol, 12 g of water, and 31.3 g of absolute ethanol are weighed and placed in a amber bottle, magnetic stirred for 1-3 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of lubricating coating.

Embodiment 3

[0056] Compositions of the primer coating: 1.0 g of 3-functional polyester acrylic resin, 0.4 g of 6-functional polyester acrylic resin, 0.6 g of vinylpyrrolidone, 0.15 g of polyether-modified organosiloxane, 0.3 g of photoinitiator 2-hydroxy-4-(2-hydroxyethoxy)-2-methylbenzeneacetone (IRGACURE 2959), and 24 g of absolute ethanol are weighted and placed in a amber bottle, magnetically stirred for 2 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of the primer coating.

[0057] Compositions of the lubricating coating: 1.0 g of polyvinylpyrrolidone, 0.4 g of polyvinylpyridine, 8.4 g of water, and 31.3 g of absolute ethanol are weighed and placed in a amber bottle, magnetic stirred for 1-3 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of lubricating coating.

Embodiment 4

[0058] Compositions of the primer coating: 5.0 g of 4-functional polyester acrylic resin, 1.8 g of hydroxyethyl methacrylate, 0.15 g of polyether-modified organosiloxane, 0.3 g of photoinitiator 2-hydroxy-2-methylphenylacetone (DAROCUR 1173), and 22.6 g of absolute ethanol are weighted and placed in a amber bottle, magnetically stirred for 2 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of the primer coating.

[0059] Compositions of the lubricating coating: 1.0 g of polyvinylpyrrolidone, 0.8 g of trimethylolpropane triacrylate, 2 g of water, 31.3 g of absolute ethanol, 0.2 g of polyethylene glycol, and 0.1 g of photoinitiator are weighed and placed in a amber bottle, magnetic stirred for 1-3 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of lubricating coating.

Embodiment 5

[0060] Compositions of the primer coating: 1.0 g of 3-functional polyester acrylic resin, 1.0 g of 6-functional polyester acrylic resin, 0.4 g of hydroxyethyl methacrylate, 0.15 g of polyether-modified organosiloxane, 0.3 g of photoinitiator 2-hydroxy-4-(2-hydroxyethoxy)-2-methylbenzeneacetone (IRGACURE 2959), and 24 g of absolute ethanol are weighted and placed in a amber bottle, magnetically stirred for 2 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of the primer coating.

[0061] Compositions of the lubricating coating: 0.18 g of (15) ethoxylated trimethylolpropane triacrylate, 1.5 g of polyvinylpyrrolidone, 6 g of water, 31.3 g of absolute ethanol, and 0.06 g of photoinitiator 2-hydroxy-4-(2-hydroxyethoxy)-2-methylphenylacetone (IRGACURE 2959) are weighed and placed in a amber bottle, magnetic stirred for 1-3 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of lubricating coating.

Embodiment 6

[0062] Compositions of the primer coating: 2.0 g of 4-functional polyester acrylic resin, 1.0 g of 6-functional polyester acrylic resin, 0.4 g of hydroxyethyl methacrylate, 0.15 g of polyether-modified organosiloxane, 0.3 g of 2-hydroxy-4 photoinitiator-(2-Hydroxyethoxy)-2-methylbenzeneacetone (IRGACURE2959) as photoinitiator, and 24 g of absolute ethanol are weighted and placed in a amber bottle, magnetically stirred for 2 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of the primer coating.

[0063] Compositions of the lubricating coating: 1.0 g of polyvinylpyrrolidone, 0.8 g of waterborne polyurethane, 0.06 g of photoinitiator 2-hydroxy-4-(2-hydroxyethoxy)-2-methylbenzeneacetone (IRGACURE 2959), 1.0 g of isopropanol, 8 g of water, and 31.3 g absolute ethanol are weighed and placed in a amber bottle, magnetic stirred for 1-3 hours, and filtered through a 500 mesh nylon gauze to obtain a mixed solution of lubricating coating.

[0064] The viscosity of the coatings in the above described embodiments were measured. It was found that the primer coating was about 1.3-2.0 mPa.Math.s, and the lubricating coating was about 16-32 mPa.Math.s.

Comparative Example 1

[0065] The commercially available jMed photocurable hydrophilic lubricating coating solution for medical catheters is used as a comparative example.

[0066] The medical catheter made of Pebax or Nylon material was wiped with a dust-free cloth and absolute ethanol and then coated with the Harland medical coating machine by dip coating. The sample catheter was immersed into the primer coating solution at a speed of 1.0-2.0 cm/s, soaked for 10 seconds, and taken out at a speed of 0.5-1.5 cm/s. It was then cured for 30 seconds to 2 minutes under the UV lamp. The sample catheter coated with the primer was immersed into the lubricating coating solution at a speed of 1.0-2.0 cm/s, soaked for 10 seconds and taken out at a speed of 0.5-1.5 cm/s. Finally, it was hung for 30 seconds to 90 seconds at rest, and cured for 240 s under the ultraviolet irradiation. The hydrophilic treatment of medical catheter was completed.

Coating Friction Test

(1) PURPOSE

[0067] To study the lubricity and durability of the coating in the present invention.

(2) METHOD

[0068] The lubricated medical catheters were vertically fixed in the sink and soaked in water for 1 minute. A 0.1 Mpa pneumatic chuck with silicone venner surface was used to clamp and pull the catheters up vertically at a speed of 10 mm/s for a length of 10-15 cm. The curve chart of the frictional force against medical catheter coating surface was obtained.

(3) RESULTS

[0069] The test results was shown in Table 1 and FIG. 1.

TABLE-US-00001 TABLE 1 Friction test results Friction test Embodiment Embodiment Embodiment Embodiment Embodiment Embodiment Comparative cycles 1 2 3 4 5 6 example 1 1 0.085 0.066 0.071 0.091 0.115 0.085 0.097 2 0.083 0.063 0.071 0.092 0.116 0.075 0.107 3 0.081 0.060 0.069 0.088 0.116 0.07 0.099 4 0.083 0.065 0.072 0.088 0.112 0.068 0.101 5 0.082 0.067 0.072 0.091 0.113 0.07 0.102 6 0.085 0.062 0.071 0.099 0.106 0.069 0.099 7 0.082 0.063 0.072 0.087 0.113 0.072 0.100 8 0.080 0.065 0.073 0.089 0.118 0.072 0.098 9 0.081 0.062 0.069 0.095 0.115 0.075 0.107 10 0.083 0.063 0.070 0.091 0.113 0.069 0.106 11 0.082 0.062 0.069 0.096 0.118 0.068 0.109 12 0.082 0.063 0.070 0.088 0.115 0.071 0.105 13 0.082 0.061 0.071 0.091 0.115 0.073 0.106 14 0.083 0.060 0.072 0.101 0.114 0.08 0.111 15 0.081 0.066 0.071 0.088 0.116 0.068 0.114 16 0.082 0.065 0.070 0.089 0.115 0.081 0.112 17 0.081 0.064 0.069 0.090 0.113 0.082 0.105 18 0.083 0.065 0.068 0.091 0.115 0.081 0.111 19 0.085 0.063 0.068 0.087 0.113 0.082 0.110 20 0.082 0.065 0.068 0.090 0.115 0.083 0.107 21 0.083 0.062 0.068 0.092 0.116 0.079 0.106 22 0.086 0.063 0.069 0.091 0.118 0.078 0.105 23 0.082 0.062 0.068 0.093 0.118 0.082 0.103 24 0.081 0.065 0.069 0.095 0.117 0.083 0.107 25 0.081 0.066 0.069 0.096 0.117 0.081 0.109

[0070] The test results in Table 1 and FIG. 1 indicate that the light-cured hydrophilic coating solution of the present invention has a lower friction force, which is less than 0.12 Ibf. The friction force of embodiment 5 is slightly higher than comparative example 1, while the embodiment 2 has the smallest friction force. The friction force of coatings of embodiment 1, 2, 3, 4 and 6 is about 0.06-0.1 Ibf. And the friction force basically remains stable in 25 cycles tests. The friction force of embodiment 1, 2, 3, 4 and 6 is less than that of comparative example 1.

(4) CONCLUSION

[0071] The friction analysis of embodiments 1 to 6 and comparative example 1 reveals that the light-cured hydrophilic coating for medical catheter of the present invention has excellent lubricity and durability and its friction is reduced by about 94% compared with uncoated medical catheter (friction of the uncoated catheter is at least 1.8 lbf).

[0072] The detailedly described embodiments of the present invention are used as examples only. The present invention is not limited to the specific embodiments described above. For those skilled in the art, any equivalent modifications and substitutions to the present invention are also within the scope of the present invention. Therefore, equivalent transformations and modifications made without departing from the spirit and scope of the present invention should be covered within the scope of the present invention.