Liquid mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and xanthine compound

Abstract

The invention relates to a liquid mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and a xanthine compound, and also to a cosmetic composition containing such a mixture. Use for caring for, making up and cleansing keratin materials.

Claims

1. A liquid mixture comprising 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and of xanthine compound (I): ##STR00003## wherein: R1, R2 and R3, independently of one another, denote a hydrogen atom or a methyl or ethyl radical; and wherein the mixture comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the xanthine compound (I) in amounts such that the weight ratio of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/xanthine compound (I) ranges from 17 to 250.

2. The mixture according to claim 1, wherein, for the compound (I), R1, R2 and R3, independently of one another, denote a hydrogen atom or a methyl radical.

3. The mixture according to claim 1, wherein the xanthine compound (I) is chosen from xanthine, caffeine, theobromine, theophylline and paraxanthine.

4. The mixture according to claim 1, wherein the xanthine compound (I) is caffeine.

5. The mixture according to claim 1, which comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the xanthine compound (I) in amounts such that the weight ratio of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/compound (I) ranges from 17 to 200.

6. A process for preparing a liquid mixture comprising a step of mixing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and a xanthine compound (I): ##STR00004## wherein: R1, R2 and R3, independently of one another, denote a hydrogen atom or a methyl or ethyl radical; heated to a temperature of between 70 and 80 C., and then a step of cooling to a temperature of between 15 and 28 C.; and wherein the mixture comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the xanthine compound (I) in amounts such that the weight ratio of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/xanthine compound (I) ranges from 17 to 250.

7. A composition comprising, in a physiologically acceptable medium, the liquid mixture of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and of xanthine compound (I) according to claim 1.

8. The composition according to claim 7, which comprises at least one additional ingredient chosen from water, oils, polyols having from 1 to 10 carbon atoms, gelling agents, surfactants, film-forming polymers, colorants, fragrances, fillers, UV screening agents, plant extracts, cosmetic and dermatological active agents, and salts.

9. The composition according to claim 7, wherein the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one is present at an amount ranging from 0.01% to 5% by weight relative to the total weight of the composition.

10. A non-therapeutic cosmetic treatment process for caring for and/or making up and/or cleansing keratin materials, comprising the application to said keratin materials of a composition according to claim 7.

11. The mixture according to claim 2, wherein the xanthine compound (I) is chosen from xanthine, caffeine, theobromine, theophylline and paraxanthine.

12. The mixture according to claim 1, which comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the xanthine compound (I) in amounts such that the weight ratio of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/compound (I) ranges from 17 to 100.

13. The mixture according to claim 2, which comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the xanthine compound (I) in amounts such that the weight ratio of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/compound (I) ranges from 17 to 200.

14. The mixture according to claim 2, which comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the xanthine compound (I) in amounts such that the weight ratio of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/compound (I) ranges from 17 to 100.

15. The mixture according to claim 3, which comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the xanthine compound (I) in amounts such that the weight ratio of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/compound (I) ranges from 17 to 200.

16. The mixture according to claim 3, which comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the xanthine compound (I) in amounts such that the weight ratio of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/compound (I) ranges from 17 to 100.

17. The mixture according to claim 4, which comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the xanthine compound (I) in amounts such that the weight ratio of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/compound (I) ranges from 17 to 200.

18. The mixture according to claim 4, which comprises 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and the xanthine compound (I) in amounts such that the weight ratio of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one/compound (I) ranges from 17 to 100.

19. The composition according to claim 7, wherein the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one is present at an amount ranging from 0.01% to 3% by weight relative to the total weight of the composition.

20. The composition according to claim 7, wherein the 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one is present at an amount ranging from 0.01% to 2.5% by weight relative to the total weight of the composition.

21. The mixture according to claim 1, wherein the xanthine compound (I) is present at an amount ranging from 0.5% to 5% by weight relative to the total weight of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and of xanthine compound (I).

22. The process according to claim 6, wherein the xanthine compound (I) is present at an amount ranging from 0.5% to 5% by weight relative to the total weight of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and of xanthine compound (I).

23. The composition according to claim 7, wherein the xanthine compound (I) is present at an amount ranging from 0.5% to 5% by weight relative to the total weight of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and of xanthine compound (I).

Description

EXAMPLE 1: VISUAL APPEARANCE OF SEVERAL MIXTURES

(1) 11 mixtures of 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one (ketone compound) and caffeine were produced in different proportions by weight described in the table below, by heating each of the mixtures to the temperature 75 C.5 C. then allowing to cool to room temperature.

(2) The appearance of the mixture at T0 was then observed by the naked eye, then the mixture was left stored at room temperature (23 C.) for 2 months and the appearance of the mixture was observed again at the end of storage. It was noted whether the mixture was liquid and homogeneous or else if it was not homogeneous, with the appearance of crystals.

(3) The following results were obtained:

(4) TABLE-US-00001 Ketone Caffeine Appearance composition (% by Appearance at T = 2 Mixture (% by weight) weight) at T0 months at room T M1 99.5 0.5 liquid liquid M2 99 1 liquid liquid M3 98 2 liquid liquid M4 97 3 liquid liquid M5 96 4 liquid liquid M6 95 5 liquid liquid M7 94 6 liquid crystals M8 93 7 crystals crystals M9 92 8 crystals crystals M10 91 9 crystals crystals M11 90 10 crystals crystals

(5) It was thus observed that the mixtures M1 to M6, containing 0.5 to 5% caffeine, are liquid and homogeneous at T0 and after 2 months of storage at room temperature, whereas the mixtures M7 to M11, containing 6 to 10% caffeine, are not homogeneous (appearance of crystals) after 2 months of storage at room temperature.

(6) Thus, the mixtures M1 to M6 are appropriate for use in the industrial manufacture of compositions, especially of cosmetic compositions, by simple addition of the liquid mixture with the other constituents in order to obtain the final desired composition.

EXAMPLE 2

(7) TABLE-US-00002 Acrylates/C.sub.10-C.sub.30 alkyl acrylate crosslinked polymer 0.9% (Carbopol Ultrez 20 Polymer from Noveon) PEG-8 6% Mixture M6 containing 95% by weight of 0.53% 4-(3-ethoxy-4-hydroxyphenyl) butan-2-one and 5% by weight of caffeine Sodium hydroxide 0.35% Water q.s. 100%

(8) The composition is stable and homogeneous.