3-AMINO-[1,2,4]-TRIAZOLE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH
20200331904 ยท 2020-10-22
Inventors
- Estella Buscato Arsequell (Frankfurt am Main, DE)
- Klemens Minn (Hattersheim, DE)
- Harald Jakobi (Frankfurt, DE)
- Hansjoerg Dietrich (Liederbach am Taunus, DE)
- Anu Bheemaiah Machettira (Frankfurt am Main, DE)
- Elmar Gatzweiler (Bad Nauheim, DE)
- Dirk Schmutzler (Hattersheim, DE)
- Christopher Hugh Rosinger (Hofheim, DE)
Cpc classification
C07D417/12
CHEMISTRY; METALLURGY
A01N43/72
HUMAN NECESSITIES
A01N43/90
HUMAN NECESSITIES
International classification
Abstract
The invention relates to 3-amino-[1,2,4]-triazole derivatives of the general formula (I) and their agrochemically compatible salts
##STR00001##
and to the use thereof for controlling unwanted plant growth.
Claims
1. A compound of formula (I) ##STR00063## or an agrochemically compatible salt thereof, in which R.sup.1 is selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, amino, C(O)OH, C(O)NH.sub.2; (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-haloalkylcarbonyl, (C.sub.1-C.sub.6)-alkylcarbonyloxy, (C.sub.1-C.sub.6)-haloalkylcarbonyloxy, (C.sub.1-C.sub.6)-alkylcarbonyl-(C.sub.1-C.sub.4)-alkyl; (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.4)-alkoxyalkyl, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.1-C.sub.6)-haloalkoxycarbonyl, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkoxycarbonyl-(C.sub.1-C.sub.6)-haloalkyl; (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-haloalkenyl, (C.sub.2-C.sub.6)-alkenylcarbonyl, (C.sub.2-C.sub.6)-haloalkenylcarbonyl, (C.sub.2-C.sub.6)-alkenyloxy, (C.sub.2-C.sub.6)-haloalkenyloxy, (C.sub.2-C.sub.6)-alkenyloxycarbonyl, (C.sub.2-C.sub.6)-haloalkenyloxycarbonyl; (C.sub.2-C.sub.6)-alkynyl, (C.sub.2-C.sub.6)-haloalkynyl, (C.sub.2-C.sub.6)-alkynylcarbonyl, (C.sub.2-C.sub.6)-haloalkynylcarbonyl, (C.sub.2-C.sub.6)-alkynyloxy, (C.sub.2-C.sub.6)-haloalkynyloxy, (C.sub.2-C.sub.6)-alkynyloxycarbonyl, (C.sub.2-C.sub.6)-haloalkynyloxycarbonyl; tri-(C.sub.1-C.sub.6)-alkylsilyl-(C.sub.2-C.sub.6)-alkynyl, di-(C.sub.1-C.sub.6)-alkylsilyl-(C.sub.2-C.sub.6)-alkynyl, mono-(C.sub.1-C.sub.6)-alkylsilyl-(C.sub.2-C.sub.6)-alkynyl, phenylsilyl-(C.sub.2-C.sub.6)-alkynyl; (C.sub.6-C.sub.14)-aryl, (C.sub.6-C.sub.14)-aryloxy, (C.sub.6-C.sub.14)-arylcarbonyl and (C.sub.6-C.sub.14)-aryloxycarbonyl, each of which may be substituted in the aryl moiety by halogen, (C.sub.1-C.sub.6)-alkyl and/or (C.sub.1-C.sub.6)-haloalkyl; (C.sub.6-C.sub.14)-aryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.6-C.sub.14)-aryl-(C.sub.1-C.sub.6)-alkoxy, (C.sub.6-C.sub.14)-aryl-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.6-C.sub.14)-aryl-(C.sub.1-C.sub.6)-alkylcarbonyloxy, (C.sub.6-C.sub.14)-aryl-(C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.6-C.sub.4)-aryl-(C.sub.1-C.sub.6)-alkoxycarbonyloxy; mono-((C.sub.1-C.sub.6)-alkyl)amino, mono-((C.sub.1-C.sub.6)-haloalkyl)amino, di-((C.sub.1-C.sub.6)-alkyl)amino, di-((C.sub.1-C.sub.6)-haloalkyl)amino, ((C.sub.1-C.sub.6)-alkyl-(C.sub.1-C.sub.6)-haloalkyl)amino, N((C.sub.1-C.sub.6)-alkanoyl)amino, N((C.sub.1-C.sub.6)-haloalkanoyl)amino, aminocarbonyl-(C.sub.1-C.sub.6)-alkyl, di-(C.sub.1-C.sub.6)-alkylaminocarbonyl-(C.sub.1-C.sub.6)-alkyl; mono-((C.sub.1-C.sub.6)-alkyl)aminocarbonyl, mono-((C.sub.1-C.sub.6)-haloalkyl)aminocarbonyl, di-((C.sub.1-C.sub.6)-alkyl)aminocarbonyl, di-((C.sub.1-C.sub.6)-haloalkyl)aminocarbonyl, ((C.sub.1-C.sub.6)-alkyl-(C.sub.1-C.sub.6)-haloalkyl)aminocarbonyl, N((C.sub.1-C.sub.6)-alkanoyl)aminocarbonyl, N((C.sub.1-C.sub.6)-haloalkanoyl)aminocarbonyl, mono-((C.sub.6-C.sub.14)-aryl)aminocarbonyl, di-((C.sub.6-C.sub.14)-aryl)aminocarbonyl, di-((C.sub.1-C.sub.6)-alkyl)amino, with the proviso that the two (C.sub.1-C.sub.6)-alkyl radicals form a cycle that may optionally be interrupted by NH, O or S; (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkoxy; (C.sub.3-C.sub.8)-cycloalkyl which may optionally be substituted on the cycloalkyl radical by (C.sub.1-C.sub.6)-alkyl and/or halogen; (C.sub.3-C.sub.8)-cycloalkoxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkoxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-haloalkoxy, (C.sub.3-C.sub.8)-cycloalkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-haloalkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-haloalkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkoxycarbonyloxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-halogenalkylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkoxycarbonyloxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-haloalkoxycarbonyloxy; (C.sub.5-C.sub.6)-cycloheteroalkyl which may optionally be interrupted independently of one another once or twice by NH, O or S; (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkenyloxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkoxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkoxy, (C.sub.3-C.sub.8)-cycloalkenylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenyloxycarbonyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkenylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkenyloxycarbonyloxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkoxycarbonyloxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkoxycarbonyloxy; hydroxy-(C.sub.1-C.sub.6)-alkyl, hydroxy-(C.sub.1-C.sub.6)-alkoxy, cyano-(C.sub.1-C.sub.6)-alkoxy, cyano-(C.sub.1-C.sub.6)-alkyl; (C.sub.1-C.sub.6)-alkylsulfonyl, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-alkylsulfinyl, (C.sub.1-C.sub.6)-haloalkylsulfonyl, (C.sub.1-C.sub.6)-haloalkylthio, (C.sub.1-C.sub.6)-haloalkylsulfinyl, (C.sub.1-C.sub.6)-alkylsulfonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylsulfinyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylsulfonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylsulfinyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylsulfonyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkylsulfinyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkylsulfonyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkylthio-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkylsulfinyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkylsulfonyloxy, (C.sub.1-C.sub.6)-haloalkylsulfonyloxy, (C.sub.1-C.sub.6)-alkylthiocarbonyl, (C.sub.1-C.sub.6)-haloalkylthiocarbonyl, (C.sub.1-C.sub.6)-alkylthiocarbonyloxy, (C.sub.1-C.sub.6)-haloalkylthiocarbonyloxy, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkylcarbonyloxy; (C.sub.4-C.sub.14)-arylsulfonyl, (C.sub.6-C.sub.14)-arylthio, (C.sub.6-C.sub.14)-arylsulfinyl, (C.sub.3-C.sub.8)-cycloalkylthio, (C.sub.3-C.sub.8)-alkenylthio, (C.sub.3-C.sub.8)-cycloalkenylthio, (C.sub.3-C.sub.6)-alkynylthio; R.sup.2 is selected from the group consisting of (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-haloalkylcarbonyl, (C.sub.1-C.sub.6)-alkylcarbonyloxy, (C.sub.1-C.sub.6)-haloalkylcarbonyloxy, (C.sub.1-C.sub.6)-alkylcarbonyl-(C.sub.1-C.sub.4)-alkyl; (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.1-C.sub.6)-haloalkoxycarbonyl, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkoxycarbonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkoxycarbonyl-(C.sub.1-C.sub.6)-haloalkyl; (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-haloalkenyl, (C.sub.2-C.sub.6)-alkenylcarbonyl, (C.sub.2-C.sub.6)-haloalkenylcarbonyl, (C.sub.2-C.sub.6)-alkenyloxy, (C.sub.2-C.sub.6)-haloalkenyloxy, (C.sub.2-C.sub.6)-alkenyloxycarbonyl, (C.sub.2-C.sub.6)-haloalkenyloxycarbonyl; (C.sub.2-C.sub.6)-alkynyl, (C.sub.2-C.sub.6)-haloalkynyl, (C.sub.2-C.sub.6)-alkynylcarbonyl, (C.sub.2-C.sub.6)-haloalkynylcarbonyl, (C.sub.2-C.sub.6)-alkynyloxy, (C.sub.2-C.sub.6)-haloalkynyloxy, (C.sub.2-C.sub.6)-alkynyloxycarbonyl, (C.sub.2-C.sub.6)-haloalkynyloxycarbonyl; tri-(C.sub.1-C.sub.6)-alkylsilyl-(C.sub.2-C.sub.6)-alkynyl, di-(C.sub.1-C.sub.6)-alkylsilyl-(C.sub.2-C.sub.6)-alkynyl, mono-(C.sub.1-C.sub.6)-alkylsilyl-(C.sub.2-C.sub.6)-alkynyl, phenylsilyl-(C.sub.2-C.sub.6)-alkynyl; (C.sub.6-C.sub.14)-aryl, (C.sub.6-C.sub.14)-aryloxy, (C.sub.6-C.sub.14)-arylcarbonyl and (C.sub.6-C.sub.14)-aryloxycarbonyl, each of which may be substituted in the aryl moiety by halogen, (C.sub.1-C.sub.6)-alkyl and/or (C.sub.1-C.sub.6)-haloalkyl; (C.sub.6-C.sub.14)-aryl-(C.sub.1-C.sub.6)-alkyl, (C.sub.6-C.sub.14)-aryl-(C.sub.1-C.sub.6)-alkoxy, (C.sub.6-C.sub.14)-aryl-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.6-C.sub.14)-aryl-(C.sub.1-C.sub.6)-alkylcarbonyloxy, (C.sub.6-C.sub.14)-aryl-(C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.6-C.sub.14)-aryl-(C.sub.1-C.sub.6)-alkoxycarbonyloxy; mono-((C.sub.1-C.sub.6)-alkyl)amino, mono-((C.sub.1-C.sub.6)-haloalkyl)amino, di-((C.sub.1-C.sub.6)-alkyl)amino, di-((C.sub.1-C.sub.6)-haloalkyl)amino, ((C.sub.1-C.sub.6)-alkyl-(C.sub.1-C.sub.6)-haloalkyl)amino, N((C.sub.1-C.sub.6)-alkanoyl)amino, N((C.sub.1-C.sub.6)-haloalkanoyl)amino, aminocarbonyl-(C.sub.1-C.sub.6)-alkyl, di-(C.sub.1-C.sub.6)-alkylaminocarbonyl-(C.sub.1-C.sub.6)-alkyl; mono-((C.sub.1-C.sub.6)-alkyl)aminocarbonyl, mono-((C.sub.1-C.sub.6)-haloalkyl)aminocarbonyl, di-((C.sub.1-C.sub.6)-alkyl)aminocarbonyl, di-((C.sub.1-C.sub.6)-haloalkyl)aminocarbonyl, ((C.sub.1-C.sub.6)-alkyl-(C.sub.1-C.sub.6)-haloalkyl)aminocarbonyl, N((C.sub.1-C.sub.6)-alkanoyl)aminocarbonyl, N((C.sub.1-C.sub.6)-haloalkanoyl)aminocarbonyl, mono-((C.sub.6-C.sub.14)-aryl)aminocarbonyl, di-((C.sub.6-C.sub.14)-aryl)aminocarbonyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-alkoxycarbonyl-(C.sub.1-C.sub.6)-alkoxy; (C.sub.3-C.sub.8)-cycloalkyl which may optionally be substituted in the cycloalkyl radical by (C.sub.1-C.sub.6)-alkyl and/or halogen; (C.sub.3-C.sub.8)-cycloalkoxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkoxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-haloalkoxy, (C.sub.3-C.sub.8)-cycloalkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-haloalkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-haloalkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkoxycarbonyloxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-haloalkylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkoxycarbonyloxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-haloalkoxycarbonyloxy; (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkenyloxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkoxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkoxy, (C.sub.3-C.sub.8)-cycloalkenylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenyloxycarbonyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkenylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkenyloxycarbonyloxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkylcarbonyloxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-alkoxycarbonyloxy, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.6)-haloalkoxycarbonyloxy; hydroxy-(C.sub.1-C.sub.6)-alkyl, hydroxy-(C.sub.1-C.sub.6)-alkoxy, cyano-(C.sub.1-C.sub.6)-alkoxy, cyano-(C.sub.1-C.sub.6)-alkyl; (C.sub.1-C.sub.6)-alkylsulfonyl, (C.sub.1-C.sub.6)-alkylthio, (C.sub.1-C.sub.6)-alkylsulfinyl, (C.sub.1-C.sub.6)-haloalkylsulfonyl, (C.sub.1-C.sub.6)-haloalkylthio, (C.sub.1-C.sub.6)-haloalkylsulfinyl, (C.sub.1-C.sub.6)-alkylsulfonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylsulfinyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylsulfonyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkylsulfinyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylsulfonyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkylsulfinyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkylsulfonyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkylthio-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-haloalkylsulfinyl-(C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkylsulfonyloxy, (C.sub.1-C.sub.6)-haloalkylsulfonyloxy, (C.sub.1-C.sub.6)-alkylthiocarbonyl, (C.sub.1-C.sub.6)-haloalkylthiocarbonyl, (C.sub.1-C.sub.6)-alkylthiocarbonyloxy, (C.sub.1-C.sub.6)-haloalkylthiocarbonyloxy, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-alkylthio-(C.sub.1-C.sub.6)-alkylcarbonyloxy; (C.sub.4-C.sub.14)-arylsulfonyl, (C.sub.6-C.sub.14)-arylthio, (C.sub.6-C.sub.14)-arylsulfinyl, (C.sub.3-C.sub.8)-cycloalkylthio, (C.sub.3-C.sub.8)-alkenylthio, (C.sub.3-C.sub.8)-cycloalkenylthio, (C.sub.3-C.sub.6)-alkynylthio; or R.sup.1 and R.sup.2 together with the carbon atom or nitrogen atom to which they are bonded form a saturated five- to seven-membered ring that may be interrupted by the Y group, where Y is selected from C(O), O, S, S(O), S(O).sub.2, NR.sup.1a, C(O)NR.sup.1a, where the saturated five- to seven-membered ring may be substituted by m substituents selected from halogen, acetyl, (C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl, trifluoromethyl, COOMe, COOEt, CONH.sub.2, nitrile, (C.sub.1-C.sub.6)-alkylsulfonyl, (C.sub.3-C.sub.6)-cycloalkylsulfonyl, phenylsulfonyl or phenyl-(C.sub.1-C.sub.6)-alkylsulfonyl, and where R.sup.1a is selected from hydrogen, acetyl, trifluoroacetyl, (C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl, (C.sub.3-C.sub.6)-cycloalkylcarbonyl, (C.sub.3-C.sub.6)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.4)-alkylsulfonyl, phenyl, phenyl-(C.sub.1-C.sub.6)-alkyl, phenylcarbonyl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 2-pyridinylcarbonyl, 3-pyridinylcarbonyl, 4-pyridinylcarbonyl, where the 14 latter radicals may be substituted by halogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkyloxy, nitrile or trifluoromethyl; R.sup.3 is hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-haloalkylcarbonyl or (C.sub.1-C.sub.6)-alkylcarbonyloxy; R.sup.4 and R.sup.5 are each independently of one another hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, hydroxyl, (C.sub.1-C.sub.6)-alkoxy or (C.sub.1-C.sub.6)-haloalkoxy; or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached form a saturated three- to seven-membered ring which may contain one or more heteroatoms selected from the group consisting of oxygen or sulfur or NH or NR.sup.1a; R.sup.6 and R.sup.7 are each independently of one another hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.6-C.sub.14)-aryl, (C.sub.6-C.sub.14)-aryloxy, (C.sub.6-C.sub.14)-arylcarbonyl or (C.sub.6-C.sub.14)-aryloxycarbonyl; or R.sup.6 and R.sup.7 together with the carbon to which they are attached form a (C.sub.3-C.sub.7)-alkylene group which may contain one or more oxygen and/or sulfur atoms, where the (C.sub.3-C.sub.7)-alkylene group may be mono- or polysubstituted by halogen and the respective halogen substituents may be identical or different; R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are each independently of one another hydrogen, halogen, cyano, C(O)OH, C(O)NH.sub.2, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-alkyloxycarbonyl, (C.sub.1-C.sub.6)-alkylaminocarbonyl, (C.sub.1-C.sub.6)-dialkylaminocarbonyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.2-C.sub.6)-haloalkynyl, (C.sub.2-C.sub.6)-alkynylcarbonyl, (C.sub.2-C.sub.6)-haloalkynylcarbonyl, (C.sub.2-C.sub.6)-alkynyloxy, (C.sub.2-C.sub.6)-haloalkynyloxy, (C.sub.2-C.sub.6)-alkynyloxycarbonyl, (C.sub.2-C.sub.6)-haloalkynyloxycarbonyl or nitro, where the R.sup.9 and R.sup.10 radicals may be joined by an OCH.sub.2O-group to form a ring; X represents a bond, CH.sub.2, O, S, carbonyl, NH, CR.sup.12R.sup.13, NR.sup.14, CH.sub.2O or CH.sub.2S, where in the two latter groups the carbon atom is attached to the aromatic moiety and the heteroatom O or S is attached to the partially hydrogenated moiety of the amine; where, when n=0, X cannot be a bond; R.sup.12 and R.sup.13 are each independently of one another hydrogen, (C.sub.1-C.sub.6)-alkyl or (C.sub.1-C.sub.6)-haloalkyl; R.sup.14 is hydrogen, (C.sub.1-C.sub.6)alkyl or (C.sub.1-C.sub.6)haloalkyl; n is the serial number 0, 1 or 2; and m is the serial number 0, 1, 2, 3, 4 or 5.
2. A compound of formula (I) as claimed in claim 1, where R.sup.1 is hydrogen, cyano, fluorine, chlorine, bromine, iodine, nitro, trimethylsilylethynyl, methyl, ethyl, propyl, isopropyl, butyl, tert-butyl, n-pentyl, n-heptyl, cyclopropyl, cyclobutyl, acetyl, ethynyl, amino, dimethylamino, trifluoromethyl, difluoromethyl, monofluoromethyl, methoxy, ethoxy or methoxymethyl.
3. A compound of formula (I) as claimed in claim 1, where R.sup.1 is hydrogen, chlorine, phenyl, 2-methylphenyl, 3-trifluoromethylphenyl, methyl, ethyl, isopropyl, butyl, tert-butyl, n-pentyl, n-heptyl, trifluoromethyl, 1-methylcyclopropyl, 1-(p-xylyl)-cyclopropyl, 1-(2,4-dichlorophenyl)cyclopropyl, amino, dimethylamino, trifluoromethyl, difluoromethyl, monofluoromethyl, CHFCH.sub.3, CF(CH.sub.3).sub.2, CHF(CH.sub.2CH.sub.3), 1-fluorocyclopropyl, cyclopentyl, methoxy, ethoxy, methoxymethyl, ethoxymethyl, thiomethyl, methylthio or methoxy.
4. A compound of formula (i) as claimed in claim 1, where R.sup.1 and R.sup.2 together with the carbon or nitrogen atom to which they are attached form a saturated six- or seven-membered ring selected from the following rings (a) to (k): ##STR00064## ##STR00065## where the saturated six- or seven-membered ring may be substituted by m substituents selected from halogen, acetyl, (C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.6)-cycloalkyl, trifluoromethyl, (C.sub.1-C.sub.6)-alkylsulfonyl, (C.sub.3-C.sub.6)-cycloalkylsulfonyl or phenylsulfonyl, and where R.sup.1a is hydrogen, acetyl, (C.sub.1-C.sub.4)-alkyl, (C.sub.1-C.sub.4)-alkylsulfonyl or phenylcarbonyl, and where the phenyl may be substituted by a halogen.
5. A compound of formula (I) as claimed in claim 1, where R.sup.3 is hydrogen.
6. A compound of formula (I) as claimed in claim 1, where R.sup.4 and R.sup.5 each independently of one another are hydrogen, methyl, ethyl, propyl, cyclopropyl, hydroxyl or methoxy.
7. A compound of formula (I) as claimed in claim 1, where R.sup.6 and R.sup.7 independently of one another are hydrogen, methyl or phenyl.
8. A compound of formula (I) as claimed in claim 1, where R.sup.8 is hydrogen, methyl or fluorine.
9. A compound of formula (I) as claimed in claim 1, where R.sup.9 is hydrogen or methyl.
10. A compound of formula (I) as claimed in claim 1, where R.sup.10 is hydrogen, methyl, propyl, isopropyl, butyl, tert-butyl, dimethylamino, fluorine, chlorine, bromine, iodine, ethenyl, ethynyl, methylethynyl, ethylethynyl, MeOCH.sub.2CC, cyano, COOMe or CONH.sub.2.
11. A compound of formula (I) as claimed in claim 1, where R.sup.11 is hydrogen or methyl.
12. A compound of formula (I) as claimed in claim 1, where X represents CH.sub.2, O or a bond, where, when n=0, X cannot be a bond.
13. A compound of formula (I) ##STR00066## as claimed in claim 1, where the chiral carbon atom labeled (*) has an (R) configuration.
14. A compound of formula (I) ##STR00067## as claimed in claim 1, where the chiral carbon atom labeled (*) has an (R) configuration and the chiral carbon atom labeled (**) has an (S) configuration.
15. A process for preparing a compound of formula (I) or agrochemically compatible salt thereof: ##STR00068## comprising reacting a compound of formula (II) ##STR00069## where Z.sup.1 represents an exchangeable radical or a leaving group with an amine of formula (III) ##STR00070## or with an acid addition salt of the amine of formula (III).
16. The process as claimed in claim 15, where Z.sup.1 is fluorine, chlorine, bromine, iodine, (C.sub.1-4)-alkylsulfanyl, (C.sub.1-4)-alkylsulfinyl, (C.sub.1-4)-alkylsulfonyl, an unsubstituted or a mono- or poly-fluorine-, -chlorine-, -bromine- or (C.sub.1-4)-alkyl- or (C.sub.1-4)-alkoxy-substituted phenyl-(C.sub.1-4)-alkylsulfonyl or (C.sub.1-4)-alkylphenylsulfonyl.
17. The process as claimed in claim 15, wherein a compound of formula (II) is reacted with an amine of the formula (III), wherein the reaction is catalyzed by the reagents potassium phosphate, copper(I) iodide or N,N-diethyl-2-hydroxybenzamide, or in the manner of Buchwald-Hartwig coupling by transition metal catalyst systems and bases.
18. A herbicidal composition or plant growth-regulating composition comprising one or more compounds of formula (I) or salts thereof as claimed in claim 1.
19. A method of controlling harmful plants or regulating the growth of a plant, comprising applying an effective amount of one or more compounds of formula (I) or salts thereof as claimed in claim 1 to one or more plants, plant parts, plant seeds and/or an area under cultivation.
20. A product comprising one or more compounds of formula (I) or salts thereof as claimed in claim 1 as a herbicide or as a plant growth regulator.
21. The product as claimed in claim 20, wherein the one or more compounds of formula (I) or salts thereof are used to control harmful plants and/or to regulate the growth of plants in one or more crops of useful plants or ornamental plants.
22. The product as claimed in claim 20, wherein the crop plants are transgenic crop plants.
Description
A. SYNTHESIS EXAMPLES
N-[(1R)-indan-1-yl]-4-oxo-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine (ex. I-369)
[0443] To a solution of 0.050 g (0.18 mmol) of N-[(1R)-indan-1-yl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine in 5 ml of acetic acid were added 0.02 ml (0.18 mmol) of hydrogen peroxide and catalytic amounts of sodium tungstate, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure without further purification. By column chromatography purification of the resultant crude product (acetonitrile/water gradient), N-[(1R)-indan-1-yl]-4-oxo-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine (0.015 g, 28% of theory) was isolated in solid form.
N-[(1R)-indan-1-yl]-4,4-dioxo-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepin-2-amine (ex. I-364)
[0444] To a solution of 0.050 g (0.18 mmol) of N-[(1R)-indan-1-yl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine in 5 ml of acetic acid were added 0.04 ml (0.36 mmol) of hydrogen peroxide and catalytic amounts of sodium tungstate, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure without further purification. By column chromatography purification of the resultant crude product (acetonitrile/water gradient), N-[(1R)-indan-1-yl]-4,4-dioxo-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine (0.026 g, 47% of theory) was isolated in solid form.
[0445] N-[(1R)-indan-1-yl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine (ex. I-352) To a solution under argon of 0.3 g (1.28 mmol) of 2-bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine and 0.25 g (1.92 mmol) of (1R)-indane-1-amine in 5 ml of dry 1,4-dioxane were added 0.13 g (0.25 mmol) of BrettPhos, 0.16 g (0.12 mmol) of 3G BrettPhos precatalyst and 0.30 g (3.2 mmol) of sodium tert-butoxide. The resulting reaction mixture was then stirred in a microwave apparatus at a temperature of 120 C. for 1.5 h and, after cooling to room temperature, concentrated under reduced pressure. The resulting residue was taken up with dichloromethane, water was added, and the water phase was thoroughly extracted repeatedly with dichloromethane. The combined organic phases were washed with sat. sodium chloride solution, dried over sodium sulfate and concentrated under reduced pressure. By column chromatography purification of the resultant crude product (ethyl acetate/heptane gradient), N-[(1R)-indan-1-yl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine (0.19 g, 52% of theory) was isolated in solid form.
2-bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine
[0446] 8 g (46.9 mmol) of 2-amino-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine, 11.5 g of copper(II) bromide (51.6 mmol) and 10.7 g (93.9 mmol) of tert-butyl nitrite were heated in 50 ml of acetonitrile at 90 C. for 2 h. The reaction mixture was concentrated under reduced pressure without further purification. The resulting residue was taken up with dichloromethane and washed with 150 ml of 2 N NaOH, and the water phase was thoroughly extracted repeatedly with dichloromethane. The combined organic phases were washed with sat. sodium chloride solution, dried over sodium sulfate and concentrated under reduced pressure. By column chromatography purification of the resultant crude product (ethyl acetate/heptane gradient), 2-bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine (1.7 g, 15% of theory) was isolated as an oil.
N-[(1R)-indan-1-yl]-4-oxo-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine (ex. I-369)
[0447] To a solution of 0.050 g (0.18 mmol) of N-[(1R)-indan-1-yl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine in 5 ml of acetic acid were added 0.02 ml (0.18 mmol) of hydrogen peroxide and catalytic amounts of sodium tungstate, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure without further purification. By column chromatography purification of the resultant crude product (acetonitrile/water gradient), N-[(1R)-indan-1-yl]-4-oxo-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine (0.015 g, 28% of theory) was isolated in solid form.
N-[(1R)-indan-1-yl]-4,4-dioxo-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepin-2-amine (ex. I-364)
[0448] To a solution of 0.050 g (0.18 mmol) of N-[(1R)-indan-1-yl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine in 5 ml of acetic acid were added 0.04 ml (0.36 mmol) of hydrogen peroxide and catalytic amounts of sodium tungstate, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure without further purification. By column chromatography purification of the resultant crude product (acetonitrile/water gradient), N-[(1R)-indan-1-yl]-4,4-dioxo-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b][1,3]thiazepine-2-amine (0.026 g, 47% of theory) was isolated in solid form.
[0449] NMR Data of Selected Examples
[0450] NMR Peak List Method
[0451] The 1H NMR data of selected examples are noted in the form of 1H NMR peak lists. For each signal peak, first the value in ppm and then the signal intensity in round brackets are listed. The pairs of 6 value-signal intensity numbers for different signal peaks are listed with separation from one another by semicolons.
[0452] The peak list for one example therefore takes the form of:
.sub.1 (intensity.sub.1); .sub.2 (intensity.sub.2); . . . .sub.i (intensity.sub.i); . . . ; .sub.n (intensity.sub.n)
[0453] The intensity of sharp signals correlates with the height of the signals in a printed example of an NMR spectrum in cm and shows the true ratios of the signal intensities. In the case of broad signals, several peaks or the middle of the signal and the relative intensity thereof may be shown in comparison to the most intense signal in the spectrum.
[0454] For calibration of the chemical shift of 1H NMR spectra we use tetramethylsilane and/or the chemical shift of the solvent, particularly in the case of spectra measured in DMSO. Therefore, the tetramethylsilane peak may but need not occur in NMR peak lists.
[0455] The lists of the 1H NMR peaks are similar to the conventional 1H NMR printouts and thus usually contain all peaks listed in a conventional NMR interpretation.
[0456] In addition, like conventional 1H NMR printouts, they may show solvent signals, signals of stereoisomers of the target compounds, which likewise form part of the subject matter of the invention, and/or peaks of impurities.
[0457] In the reporting of compound signals in the delta range of solvents and/or water, our lists of 1H NMR peaks show the usual solvent peaks, for example peaks of DMSO in DMSO-D.sub.6 and the peak of water, which usually have a high intensity on average.
[0458] The peaks of stereoisomers of the target compounds and/or peaks of impurities usually have a lower intensity on average than the peaks of the target compounds (for example with a purity of >90%).
[0459] Such stereoisomers and/or impurities may be typical of the particular preparation process. Their peaks can thus help in identifying reproduction of our preparation process with reference to by-product fingerprints.
[0460] An expert calculating the peaks of the target compounds by known methods (MestreC, ACD simulation, but also with empirically evaluated expected values) can, if required, isolate the peaks of the target compounds, optionally using additional intensity filters. This isolation would be similar to the relevant peak picking in conventional 1H NMR interpretation.
[0461] Further details of 1H NMR peak lists can be found in the Research Disclosure Database Number 564025.
[0462] 1H-NMR
[0463] I-019: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0464] =7.5224 (2.0); 7.5068 (5.2); 7.5027 (6.0); 7.4943 (2.3); 7.4790 (0.7); 7.2640 (1.0); 7.2223 (1.2); 7.2105 (1.7); 7.1848 (0.8); 7.1728 (1.6); 7.1607 (0.8); 7.1449 (1.0); 7.1336 (1.3); 7.1205 (0.5); 6.2563 (0.6); 6.2417 (0.6); 5.0460 (0.5); 4.7458 (0.3); 4.7255 (0.4); 4.7198 (0.4); 4.7112 (0.4); 4.6935 (0.3); 4.0784 (0.4); 4.0701 (0.4); 4.0151 (2.2); 3.9084 (0.3); 3.8994 (16.0); 3.3251 (0.7); 3.3056 (49.9); 3.1739 (1.4); 3.1652 (1.4); 2.9319 (0.4); 2.9075 (0.6); 2.8977 (0.5); 2.7802 (0.4); 2.7679 (0.6); 2.7539 (0.6); 2.7426 (0.5); 2.6119 (0.6); 2.5207 (1.1); 2.5180 (1.4); 2.5151 (1.4); 2.5030 (87.2); 2.5001 (119.5); 2.4973 (90.2); 2.4362 (0.7); 2.4126 (0.3); 2.3875 (0.6); 2.3842 (0.7); 1.8281 (0.5); 1.8139 (0.5); 0.0002 (12.0)
[0465] I-022: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0466] =7.5927 (11.1); 7.5756 (6.1); 7.5406 (3.1); 7.5214 (5.8); 7.5005 (3.8); 7.4844 (4.6); 7.4668 (2.2); 7.2961 (2.8); 7.1364 (1.0); 7.1072 (7.5); 7.0692 (4.5); 7.0507 (2.4); 6.2195 (1.9); 6.1996 (2.0); 4.6967 (2.7); 4.6145 (0.6); 4.6055 (0.6); 4.5968 (0.6); 4.5774 (0.6); 4.5391 (0.6); 4.5012 (0.4); 4.4938 (0.3); 4.1490 (0.4); 4.1368 (0.5); 4.0996 (0.6); 4.0796 (0.6); 3.9984 (6.0); 3.8991 (0.4); 3.8879 (0.5); 3.8311 (0.7); 3.7857 (1.2); 3.7762 (1.2); 3.3258 (312.7); 2.9944 (16.0); 2.7674 (0.9); 2.7277 (2.6); 2.7107 (3.2); 2.6966 (3.1); 2.6750 (2.4); 2.6703 (2.7); 2.6467 (0.8); 2.5410 (134.1); 2.5061 (261.4); 2.5017 (334.7); 2.4972 (245.3); 2.3669 (0.6); 2.3284 (2.0); 1.9082 (3.4); 1.8016 (1.0); 1.7788 (1.8); 1.7583 (1.9); 1.7211 (1.2); 1.6918 (1.7); 1.2585 (0.5); 1.2392 (1.6); 0.8525 (0.4); 0.0002 (10.3)
[0467] I-023: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0468] =7.5909 (2.6); 7.5785 (1.4); 7.5766 (1.5); 7.5729 (1.0); 7.5337 (1.0); 7.5210 (1.9); 7.5076 (1.1); 7.4841 (0.8); 7.4751 (0.5); 7.4696 (0.6); 7.2765 (0.6); 7.2651 (0.7); 7.2227 (0.8); 7.2115 (1.3); 7.1853 (0.6); 7.1735 (1.2); 7.1609 (0.6); 7.1451 (0.7); 7.1331 (0.9); 7.1216 (0.4); 6.2605 (0.4); 6.2452 (0.4); 5.0709 (0.3); 5.0511 (0.4); 5.0412 (0.3); 4.0698 (0.3); 4.0093 (1.5); 3.8995 (16.0); 3.3252 (1.1); 3.3065 (45.9); 3.2680 (0.4); 3.1732 (1.3); 3.1656 (1.3); 2.9341 (0.3); 2.9125 (0.4); 2.8988 (0.4); 2.7667 (0.4); 2.7552 (0.4); 2.7410 (0.3); 2.6118 (0.6); 2.5212 (1.4); 2.5181 (1.6); 2.5150 (1.5); 2.5062 (37.5); 2.5032 (82.2); 2.5002 (115.9); 2.4972 (83.8); 2.4942 (39.6); 2.4640 (0.4); 2.4479 (0.4); 2.4393 (0.4); 2.3878 (0.5); 2.3844 (0.7): 1.8311 (0.3); 1.8176 (0.4); 1.8130 (0.4); 0.0053 (0.4); 0.0002 (15.0); 0.0057 (0.6)
[0469] I-024: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0470] =11.9373 (0.5); 7.2634 (1.4); 7.2514 (1.3); 7.1258 (0.9); 7.1143 (1.8); 7.1026 (1.0); 6.8425 (1.2); 6.8302 (2.2); 6.8191 (1.0); 6.7513 (2.2); 6.7379 (2.0); 6.3783 (0.9); 6.3639 (0.6); 4.7401 (1.3); 4.7303 (1.4); 4.7166 (1.1); 4.7072 (0.6); 4.5763 (1.6); 4.2532 (0.6); 4.2398 (1.3); 4.2268 (0.8); 4.2219 (0.8); 4.1900 (0.8); 4.1844 (1.0); 4.1796 (1.0); 4.1730 (1.2); 4.1665 (0.6); 4.1608 (0.7); 4.1554 (0.6); 3.9909 (3.1); 3.9583 (0.6); 3.9543 (0.6); 3.9399 (0.7); 3.8995 (16.0); 3.8776 (0.6); 3.3250 (0.6); 3.3049 (58.3); 3.1736 (0.6); 3.1649 (0.6); 2.7237 (0.6); 2.7128 (0.6); 2.7003 (0.4); 2.6146 (0.5); 2.6116 (0.8); 2.6087 (0.5); 2.5211 (1.5); 2.5180 (1.8); 2.5149 (1.8); 2.5061 (46.2); 2.5031 (100.5); 2.5001 (139.5); 2.4970 (100.1); 2.4940 (46.4); 2.3875 (0.5); 2.3840 (0.8); 2.3813 (0.5); 2.1818 (0.4); 2.0609 (0.4); 2.0554 (0.5); 2.0467 (0.8); 2.0405 (0.8); 2.0326 (1.0); 2.0257 (0.8); 2.0180 (0.7); 2.0026 (0.7); 1.8622 (0.3); 1.8088 (0.4); 1.7868 (0.4); 1.6995 (1.7); 1.6861 (1.6); 1.6439 (1.6); 1.3607 (0.8); 1.3304 (2.6); 1.2860 (0.5); 1.2763 (0.4); 1.2722 (0.4); 1.2587 (0.5); 1.2521 (0.6); 1.2364 (0.9); 1.2122 (0.4); 1.1949 (0.5); 1.1804 (0.7); 1.1749 (0.7); 1.1712 (0.7); 0.0052 (0.5); 0.0002 (19.6); 0.0057 (0.7)
[0471] 1H-NMR
[0472] I-028: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0473] =7.5541 (16.0); 7.3134 (0.8); 7.2976 (0.9); 7.1187 (1.2); 7.1075 (2.6); 7.0915 (1.2); 7.0704 (1.6); 7.0501 (0.7); 6.2212 (0.8); 6.1987 (0.8); 4.6913 (1.0); 4.6499 (0.4); 3.9977 (2.3); 3.3260 (68.6); 2.9944 (4.5); 2.7444 (0.5); 2.7262 (0.8); 2.7123 (1.0); 2.6965 (1.0); 2.6802 (0.6); 2.6700 (0.7); 2.6656 (0.6); 2.5408 (35.4); 2.5056 (59.1); 2.5014 (75.1); 2.4972 (55.5); 2.3277 (0.4); 1.9067 (1.1); 1.7779 (0.6); 1.7580 (0.6); 1.7377 (0.4); 1.7209 (0.4); 1.6887 (0.5); 1.2404 (0.5); 0.0002 (2.0)
[0474] I-029: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0475] =7.5944 (1.0); 7.5808 (1.4); 7.5619 (0.7); 7.5349 (0.8); 7.5321 (0.9); 7.5221 (1.7); 7.5193 (1.7); 7.5095 (1.5); 7.5064 (1.3); 7.4965 (1.0); 7.4934 (0.9); 7.4795 (1.1); 7.4671 (1.6); 7.4566 (1.1); 7.3276 (0.7); 7.3149 (0.7); 7.2886 (0.5); 7.2770 (0.5); 7.1231 (0.9); 7.1120 (1.7); 7.1000 (1.2); 7.0813 (0.5); 7.0728 (1.0); 7.0579 (1.0); 7.0453 (0.3); 6.2264 (0.6); 6.2113 (0.5); 6.1671 (0.3); 4.9316 (0.3); 4.9034 (0.4); 4.7170 (0.6); 4.7045 (0.5); 4.6902 (0.5); 4.6620 (0.3); 4.6554 (0.4); 4.3281 (0.4); 4.3080 (0.4); 3.9303 (0.4); 3.9198 (0.5); 3.9117 (0.6); 3.8994 (16.0); 3.6861 (0.3); 3.6768 (0.4); 3.6285 (0.5); 3.3252 (1.3); 3.3088 (29.4); 3.2682 (0.4); 3.1693 (2.6); 2.7522 (0.4); 2.7446 (0.5); 2.7401 (0.5); 2.7316 (0.5); 2.7170 (0.4); 2.7097 (0.5); 2.6998 (0.6); 2.6901 (0.5); 2.6815 (0.5); 2.6712 (0.4); 2.6149 (0.4); 2.6120 (0.7); 2.5212 (1.0); 2.5180 (1.3); 2.5149 (1.5); 2.5061 (38.3); 2.5032 (80.3); 2.5002 (109.7); 2.4972 (79.8); 2.4943 (38.0); 2.3842 (0.6); 2.3814 (0.5); 1.9513 (0.3); 1.9464 (0.3); 1.9304 (0.6); 1.9235 (0.8); 1.8964 (0.7); 1.7908 (0.4); 1.7736 (0.5); 1.7570 (0.4); 1.7394 (0.3); 1.7124 (0.4); 1.7011 (0.4); 1.6958 (0.4); 1.6817 (0.4); 0.0002 (12.2)
[0476] I-030: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0477] =7.5278 (0.6); 7.5211 (1.4); 7.5009 (4.9); 7.4927 (1.5); 7.4781 (0.4); 7.3010 (0.6); 7.1273 (0.4); 7.1162 (1.0); 7.1070 (1.7); 7.1041 (1.7); 7.0941 (0.9); 7.0822 (0.4); 7.0659 (1.0); 7.0527 (0.7); 6.1883 (0.4); 6.1714 (0.4); 4.7296 (0.3); 4.6954 (0.6); 4.0046 (1.6); 3.8995 (16.0); 3.3250 (0.7); 3.3069 (43.8); 3.1719 (0.6); 3.1662 (0.6); 2.7444 (0.4); 2.7326 (0.5); 2.7022 (0.4); 2.6925 (0.6); 2.6149 (0.4); 2.6119 (0.6); 2.6088 (0.5); 2.5211 (1.0); 2.5181 (1.2); 2.5150 (1.3); 2.5062 (35.2); 2.5032 (75.6); 2.5002 (104.2); 2.4971 (74.8); 2.4942 (34.7); 2.3876 (0.4); 2.3844 (0.6); 2.3814 (0.4); 1.9341 (0.4); 1.9137 (0.8); 1.8899 (0.4); 1.7764 (0.4); 1.7640 (0.5); 1.6919 (0.4); 1.6845 (0.4); 0.0053 (0.3); 0.0002 (13.0); 0.0056 (0.5)
[0478] I-033: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0479] =7.2714 (2.3); 7.2590 (2.8); 7.2229 (2.1); 7.2116 (3.4); 7.1840 (1.6); 7.1722 (3.1); 7.1602 (1.6); 7.1429 (2.2); 7.1311 (2.7); 7.1190 (1.0); 6.2214 (1.4); 6.2072 (1.4); 5.0709 (0.6); 5.0581 (1.4); 5.0439 (1.5); 5.0311 (0.6); 4.7398 (1.2); 4.5748 (2.4); 3.9893 (5.0); 3.9544 (0.9); 3.9442 (1.0); 3.8994 (16.0); 3.8794 (0.9); 3.3055 (76.4); 3.1736 (0.5); 3.1651 (0.5); 2.9339 (0.7); 2.9184 (0.8); 2.9137 (1.0); 2.9070 (0.9); 2.8965 (0.9); 2.7809 (0.8); 2.7663 (1.7); 2.7535 (1.5); 2.7410 (1.6); 2.7268 (1.5); 2.6146 (0.7); 2.6119 (0.9); 2.6088 (0.7); 2.5208 (1.5); 2.5180 (1.8); 2.5147 (1.9); 2.5059 (54.2); 2.5030 (115.9); 2.5000 (161.2); 2.4969 (116.5); 2.4940 (54.9); 2.4641 (0.8); 2.4582 (0.8); 2.4511 (1.2); 2.4458 (1.4); 2.4384 (1.4); 2.4305 (1.4); 2.4251 (1.2); 2.4180 (0.7); 2.4128 (0.6); 2.3843 (0.9); 2.3811 (0.7); 1.8305 (0.8); 1.8086 (1.0); 1.7970 (0.8); 1.7807 (0.4); 1.7017 (2.6); 1.6681 (1.1); 1.6366 (1.7); 1.3341 (3.6); 1.2813 (0.3); 1.2590 (0.4); 1.2496 (0.4); 1.2364 (0.4); 1.2024 (0.4); 1.1822 (0.7); 1.1682 (0.8); 0.0051 (0.5); 0.0002 (20.1); 0.0059 (0.8)
[0480] I-036: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0481] =7.8895 (2.3); 7.8795 (2.2); 7.8439 (0.7); 7.8296 (0.8); 7.7471 (1.1); 7.7342 (1.6); 7.7209 (0.7); 7.2639 (0.7); 7.2507 (0.3); 7.2244 (1.0); 7.2112 (1.4); 7.1850 (0.7); 7.1732 (1.3); 7.1618 (0.8); 7.1450 (0.8); 7.1326 (1.0); 6.2498 (0.5); 6.2435 (0.4); 5.0556 (0.4); 4.7619 (0.4); 4.7538 (0.4); 4.7475 (0.3); 4.0152 (1.5); 3.8996 (16.0); 3.7877 (0.3); 3.7774 (0.4); 3.3252 (0.9); 3.3061 (66.2); 3.2678 (0.3); 3.1735 (0.8); 3.1654 (0.9); 2.9338 (0.4); 2.9081 (0.5); 2.8944 (0.4); 2.7660 (0.5); 2.7535 (0.5); 2.7406 (0.4); 2.6122 (0.7); 2.5212 (1.0); 2.5182 (1.4); 2.5151 (1.5); 2.5061 (46.4); 2.5033 (99.3); 2.5003 (137.8); 2.4973 (101.4); 2.4944 (49.7); 2.4427 (0.6); 2.3843 (0.8); 1.8124 (0.5); 1.8027 (0.4); 0.0002 (14.3); 0.0056 (0.7)
[0482] 1H-NMR
[0483] I-042: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0484] =8.9821 (4.7); 8.9715 (2.8); 8.9571 (1.0); 8.8864 (1.5); 7.9255 (2.1); 7.9125 (2.1); 7.8949 (1.1); 7.8819 (1.0); 7.2806 (1.3); 7.2620 (1.5); 7.2407 (0.7); 7.2220 (0.7); 7.1454 (0.7); 7.1422 (0.7); 7.1254 (1.8); 7.1072 (1.6); 7.0911 (0.5); 6.8619 (1.0); 6.8436 (1.8); 6.8246 (1.0); 6.8182 (1.0); 6.7983 (0.4); 6.7641 (2.0); 6.7443 (2.7); 6.7264 (1.0); 6.4815 (0.8); 6.4619 (0.8); 6.4243 (0.6); 6.4033 (0.6); 5.0220 (0.5); 4.9795 (0.7); 4.7679 (0.4); 4.7551 (0.9); 4.7439 (0.7); 4.7347 (0.8); 4.7211 (0.5); 4.7131 (0.4); 4.6983 (0.6); 4.6743 (1.0); 4.6289 (0.5); 4.4693 (0.4); 4.3499 (0.6); 4.2711 (0.5); 4.2512 (1.0); 4.2438 (0.9); 4.2315 (0.9); 4.2226 (1.1); 4.2130 (1.0); 4.2026 (1.2); 4.1876 (1.0); 4.1700 (0.9); 4.1560 (0.6); 4.1371 (0.4); 4.1284 (0.4); 4.1105 (0.8); 4.0974 (1.9); 4.0843 (1.9); 4.0711 (0.8); 4.0331 (0.6); 4.0063 (0.8); 3.9648 (0.4); 3.9017 (16.0); 3.8355 (0.6); 3.7200 (1.7); 3.7068 (2.7); 3.6937 (1.3); 3.3220 (102.8); 3.2672 (0.5); 3.1750 (7.2); 3.1619 (7.0); 2.8133 (0.4); 2.6750 (0.8); 2.6707 (1.1); 2.6663 (0.8); 2.5407 (1.0); 2.5060 (138.0); 2.5016 (175.6); 2.4971 (131.3); 2.3328 (0.8); 2.3284 (1.0); 2.3239 (0.8); 2.0663 (0.6); 2.0544 (0.8); 2.0452 (0.9); 2.0242 (1.3); 2.0153 (1.2); 1.9999 (1.0); 1.9873 (0.9); 1.9770 (0.7); 1.2589 (0.4); 1.2492 (0.6); 1.2357 (1.5); 0.0077 (0.8); 0.0003 (19.1); 0.0084 (0.8)
[0485] I-043: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0486] =8.9774 (2.9); 8.9694 (1.2); 8.9637 (0.6); 8.9551 (0.6); 8.8828 (0.8); 7.9174 (1.2); 7.9084 (1.1); 7.8878 (0.5); 7.8789 (0.6); 7.3309 (0.6); 7.3198 (0.6); 7.2858 (0.4); 7.2729 (0.4); 7.1255 (0.7); 7.1173 (1.3); 7.1078 (0.9); 7.0952 (0.6); 7.0765 (1.0); 7.0649 (0.6); 6.2368 (0.5); 6.2199 (0.4); 4.9797 (0.3); 4.7138 (0.4); 4.7103 (0.4); 4.6563 (0.5); 4.0116 (0.3); 3.8995 (16.0); 3.8163 (0.3); 3.7107 (1.0); 3.7015 (1.4); 3.6923 (0.7); 3.3252 (1.3); 3.3075 (58.4); 3.2840 (0.4); 3.2681 (0.6); 3.1694 (2.6); 2.7445 (0.4); 2.7126 (0.4); 2.7035 (0.4); 2.6915 (0.4); 2.6767 (0.3); 2.6151 (0.4); 2.6121 (0.7); 2.6094 (0.6); 2.5214 (1.0); 2.5184 (1.3); 2.5153 (1.3); 2.5064 (43.9); 2.5034 (97.1); 2.5004 (135.8); 2.4973 (97.7); 2.4943 (45.7); 2.3879 (0.6); 2.3845 (0.8); 2.3817 (0.6); 1.9277 (0.7); 1.9078 (0.6); 1.8885 (0.5); 1.7978 (0.3); 1.7816 (0.4); 1.6975 (0.3); 0.0052 (0.5); 0.0002 (16.2); 0.0058 (0.7)
[0487] I-045: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0488] =7.2761 (0.7); 7.2661 (1.5); 7.2549 (1.0); 7.2234 (1.3); 7.2112 (2.2); 7.1839 (1.0); 7.1722 (1.8); 7.1595 (1.0); 7.1439 (1.0); 7.1304 (1.3); 7.1183 (0.5); 6.2326 (0.6); 6.2150 (1.0); 6.1997 (0.8); 5.0675 (0.6); 5.0553 (0.8); 5.0430 (0.7); 4.6729 (2.2); 4.5825 (3.2); 4.2763 (0.5); 4.0210 (0.8); 4.0129 (1.6); 4.0038 (1.1); 3.9332 (1.9); 3.9240 (3.1); 3.9160 (2.2); 3.8995 (16.0); 3.3251 (0.7); 3.3070 (62.3); 3.1736 (0.9); 3.1648 (0.8); 2.9353 (0.5); 2.9221 (0.5); 2.9165 (0.5); 2.9100 (0.6); 2.8950 (0.6); 2.7825 (0.5); 2.7674 (1.0); 2.7542 (0.9); 2.7419 (0.7); 2.7280 (0.4); 2.6150 (0.4); 2.6119 (0.6); 2.6089 (0.5); 2.5211 (1.0); 2.5179 (1.3); 2.5149 (1.4); 2.5061 (37.8); 2.5031 (81.8); 2.5000 (113.0); 2.4970 (81.5); 2.4940 (37.9); 2.4654 (0.6); 2.4593 (0.5); 2.4523 (0.8); 2.4467 (0.8); 2.4391 (0.9); 2.4315 (0.9); 2.4262 (0.7); 2.4193 (0.5); 2.4134 (0.4); 2.3843 (0.7); 2.1422 (8.0); 2.1054 (4.9); 1.8349 (0.4); 1.8250 (0.6); 1.8110 (0.7); 1.8033 (0.7); 1.7901 (0.5); 0.0053 (0.3); 0.0002 (14.2); 0.0057 (0.6)
[0489] I-046: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0490] =8.6499 (0.8); 8.6415 (1.1); 8.0000 (0.5); 7.9878 (0.8); 7.9749 (0.5); 7.7251 (2.0); 7.7122 (1.8); 7.5630 (0.8); 7.5509 (0.8); 7.5427 (0.7); 7.2890 (0.6); 7.2779 (0.7); 7.2565 (0.5); 7.2436 (0.4); 7.2283 (0.6); 7.2166 (1.2); 7.2038 (0.5); 7.1878 (0.4); 7.1767 (1.0); 7.1650 (0.9); 7.1513 (0.6); 7.1370 (0.9); 7.1245 (0.6); 6.2788 (0.4); 6.2630 (0.4); 5.0790 (0.5); 5.0660 (0.5); 5.0513 (0.3); 4.8131 (1.9); 4.7690 (1.2); 4.1739 (0.7); 4.1641 (0.5); 4.0426 (0.7); 4.0329 (0.6); 4.0178 (1.1); 3.9723 (0.8); 3.9643 (1.1); 3.8996 (16.0); 3.3251 (0.8); 3.3079 (46.0); 3.1731 (0.9); 3.1661 (0.9); 2.9156 (0.4); 2.9053 (0.5); 2.7764 (0.4); 2.7638 (0.4); 2.7503 (0.4); 2.7373 (0.3); 2.6153 (0.4); 2.6120 (0.6); 2.6088 (0.4); 2.5213 (1.0); 2.5183 (1.2); 2.5151 (1.1); 2.5064 (33.7); 2.5034 (76.4); 2.5003 (107.7); 2.4972 (77.0); 2.4942 (35.5); 2.4611 (0.5); 2.4547 (0.5); 2.4474 (0.5); 2.4420 (0.5); 2.3877 (0.4); 2.3845 (0.6); 2.3817 (0.4); 1.8309 (0.4): 1.8233 (0.4); 1.8114 (0.4); 1.7984 (0.4); 0.0052 (0.4); 0.0002 (16.2); 0.0058 (0.6)
[0491] 1H-NMR
[0492] I-047: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0493] =7.9007 (0.5); 7.8976 (0.4); 7.5884 (2.7); 7.5780 (1.4); 7.5762 (1.5); 7.5460 (0.4); 7.5328 (1.1); 7.5204 (1.6); 7.5064 (1.0); 7.4813 (0.8); 7.4682 (0.5); 7.2630 (0.6); 7.2515 (0.6); 7.1288 (0.6); 7.1150 (1.0); 7.1026 (0.6); 6.8441 (0.7); 6.8320 (1.0); 6.8191 (0.5); 6.7513 (1.1); 6.7378 (1.1); 6.4153 (0.4); 6.4030 (0.5); 4.7295 (0.6); 4.5336 (0.3); 4.2384 (0.5); 4.1874 (0.5); 4.1754 (0.5); 4.1556 (0.3); 4.0786 (0.5); 4.0697 (0.5); 4.0093 (1.4); 3.8997 (16.0); 3.3251 (0.9); 3.3056 (34.4); 3.1737 (2.4); 3.1650 (2.4); 2.6119 (0.6); 2.6088 (0.5); 2.5212 (1.1); 2.5181 (1.6); 2.5149 (1.6); 2.5062 (37.3); 2.5032 (79.8); 2.5002 (109.6); 2.4971 (77.4); 2.4941 (35.6); 2.4760 (0.3); 2.3875 (0.4); 2.3845 (0.6); 2.0403 (0.4); 2.0202 (0.4): 2.0052 (0.5); 1.2366 (0.4); 0.0052 (0.4); 0.0002 (16.6); 0.0057 (0.6)
[0494] 1-048: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0495] =8.9835 (2.7); 8.9707 (1.7); 8.9568 (0.7); 8.8859 (0.8); 7.9262 (1.1); 7.9133 (1.2); 7.8971 (0.7); 7.8847 (0.6); 7.6687 (0.3); 7.6501 (0.6); 7.6322 (0.4); 7.6007 (0.3); 7.4203 (0.4); 7.2942 (0.5); 7.2768 (0.6); 7.2379 (0.7); 7.2200 (1.2); 7.2017(0.8); 7.1841 (0.9); 7.1654 (1.1); 7.1461 (0.7); 6.3268 (0.4); 6.3054 (0.4); 5.0819 (0.4); 5.0615 (0.4); 5.0294 (0.4); 5.0122 (0.4); 4.6734 (0.4); 4.4758 (0.3); 4.0218 (0.4); 4.0046 (0.5); 3.9018 (16.0); 3.8311 (0.3); 3.7207 (0.9); 3.7078 (1.3); 3.6947 (0.7); 3.3219 (77.5); 3.2674 (0.4); 3.1684 (2.3); 3.1104 (0.4); 3.0964 (0.3); 2.9134 (0.4); 2.8984 (0.4); 2.8911 (0.4); 2.7849 (0.4); 2.7646 (0.4); 2.6751 (0.6); 2.6705 (0.8); 2.6663 (0.6); 2.6465 (0.5); 2.6314 (0.4); 2.6170 (0.4); 2.5408 (0.6); 2.5102 (56.3); 2.5059 (108.9); 2.5014 (142.1); 2.4969 (107.1); 2.4927 (55.6); 2.4571 (0.8); 2.4465 (0.7); 2.4373 (0.6); 2.4264 (0.5); 2.4176 (0.4); 2.3326 (0.7); 2.3282 (0.9); 2.3237 (0.7); 1.8275 (0.4); 1.8181 (0.5); 1.7972 (0.4); 1.2353 (0.4); 0.0079 (0.6); 0.0002 (17.3); 0.0084 (0.7)
[0496] I-049: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0497] =7.2786 (2.7); 7.2610 (3.4); 7.2285 (2.4); 7.2108 (4.7); 7.1908 (2.1); 7.1754 (3.9); 7.1577 (2.8); 7.1534 (4.0); 7.1338 (3.1); 7.1158 (1.0); 6.2550 (1.9); 6.2340 (1.9); 5.0865 (0.8); 5.0667 (2.2); 5.0462 (2.1); 5.0258 (0.8); 4.9200 (1.2); 4.6035 (1.9); 4.1830 (1.5); 4.0960 (0.4); 4.0829 (0.4); 4.0693 (0.4); 4.0274 (1.7); 3.9916 (0.9); 3.9562 (1.4); 3.9015 (16.0); 3.3206 (131.1); 3.2672 (0.3); 3.1749 (1.0); 3.1618 (1.0); 2.9521 (0.8); 2.9446 (0.9); 2.9302 (1.0); 2.9221 (1.1); 2.9126 (1.5); 2.9052 (1.5); 2.8909 (1.6); 2.8838 (1.4); 2.7948 (1.1); 2.7740 (2.2); 2.7540 (1.8); 2.7348 (1.4); 2.7139 (0.8); 2.6745 (0.8); 2.6701 (1.1); 2.6657 (0.8); 2.5402 (0.8); 2.5054 (141.7); 2.5010 (182.7); 2.4965 (139.0); 2.4617 (2.3); 2.4536 (2.2); 2.4421 (2.0); 2.4308 (2.0); 2.4228 (1.7); 2.4116 (1.0); 2.4037 (0.9); 2.3322 (0.9); 2.3277 (1.2); 2.3233 (0.9); 2.1346 (1.0); 1.8604 (0.5); 1.8391 (1.3); 1.8176 (1.5); 1.8084 (1.4); 1.7974 (0.8); 1.7873 (1.2); 1.7655 (0.4); 0.7924 (12.2); 0.7847 (8.7); 0.7725 (6.5); 0.0076 (0.9); 0.0002 (20.2); 0.0083 (1.0)
[0498] I-051: .sup.1H-NMR(400.0 MHz. d.sub.6-DMSO):
[0499] =8.3146 (0.3); 7.8803 (7.8); 7.8446 (2.6); 7.8265 (3.5); 7.7523 (3.5); 7.7330 (4.8); 7.7123 (1.9); 7.2978 (2.4); 7.1378 (0.9); 7.1188 (3.6); 7.1081 (6.9); 7.0709 (4.5); 7.0522 (2.2); 6.2208 (1.6); 4.7591 (1.4); 4.7334 (1.4); 4.6992 (2.1); 4.6928 (2.1); 4.6373 (0.6); 4.6277 (0.6); 4.5651 (0.6); 4.1368 (0.6); 4.1202 (0.6); 4.0501 (0.6); 4.0046 (5.6); 3.9032 (0.4); 3.8978 (0.4); 3.7756 (1.2); 3.7657 (1.1); 3.7133 (0.4); 3.3261 (203.2); 2.9945 (16.0); 2.7725 (0.8); 2.7682 (0.8); 2.7289 (2.5); 2.7116 (3.1); 2.6959 (2.8); 2.6752 (2.3); 2.6708 (2.6); 2.6097 (0.4); 2.5833 (0.5); 2.5410 (118.0); 2.5060 (256.1); 2.5016 (326.8); 2.4973 (235.2); 2.3676 (0.5); 2.3282 (1.8); 1.9092 (3.2); 1.8016 (0.9); 1.7809 (1.6); 1.7576 (1.7); 1.6893 (1.6); 1.2979 (0.4); 1.2631 (0.5); 1.2583 (0.6); 1.2403 (2.2); 0.9399 (0.3); 0.8533 (0.6); 0.8340 (0.3); 0.0002 (7.3); 0.0086 (0.3)
[0500] 1H-NMR
[0501] I-054: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0502] =7.5956 (1.2); 7.5828 (1.6); 7.5769 (0.7); 7.5632 (0.9); 7.5344 (1.0); 7.5232 (2.0); 7.5113 (1.8); 7.5081 (1.6); 7.4984 (1.2); 7.4949 (1.0); 7.4817 (1.2); 7.4692 (1.8); 7.4603 (1.4); 7.4574 (1.4); 7.2886 (0.9); 7.2761 (0.9); 7.2485 (0.6); 7.2354 (0.7); 7.2297 (0.8); 7.2167 (1.6); 7.2026 (0.8); 7.1909 (0.6); 7.1786 (1.5); 7.1675 (1.2); 7.1532 (1.0); 7.1415 (1.0); 7.1248 (0.6); 6.2950 (0.8); 6.2801 (0.8); 6.2329 (0.4); 6.2187 (0.4); 5.0857 (0.3); 5.0725 (0.7); 5.0596 (0.7); 5.0247 (0.4); 5.0125 (0.4); 4.9375 (0.4); 4.9091 (0.6); 4.7291 (0.6); 4.7021 (0.4); 4.3369 (0.5); 4.3086 (0.5); 4.0877 (0.4); 4.0796 (0.8); 4.0709 (0.8); 4.0619 (0.5); 3.9154 (0.7); 3.8994 (16.0); 3.6923 (0.4); 3.6828 (0.5); 3.6342 (0.6); 3.3251 (1.2); 3.3078 (68.6); 3.2680 (0.4); 3.1738 (2.6); 3.1651 (2.6); 2.9317 (0.4); 2.9258 (0.5); 2.9193 (0.6); 2.9144 (0.5); 2.9047 (0.5); 2.8998 (0.6); 2.7763 (0.5); 2.7626 (0.5); 2.7510 (0.7); 2.7372 (0.5); 2.6120 (0.6); 2.5210 (1.1); 2.5181 (1.3); 2.5150 (1.6); 2.5062 (39.8); 2.5033 (83.2); 2.5003 (113.1); 2.4972 (82.0); 2.4943 (38.9); 2.4722 (0.6); 2.4648 (0.6); 2.4595 (0.6); 2.4520 (0.6); 2.4445 (0.6); 2.4390 (0.6); 2.4314 (0.5); 2.4264 (0.5); 2.3874 (0.6); 2.3843 (0.6); 1.8409 (0.5); 1.8269 (0.6); 1.8210 (0.6); 1.8123 (0.4); 1.8070 (0.7); 1.7929 (0.4); 0.0002 (12.2)
[0503] I-055: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0504] =7.2695 (2.4); 7.2563 (2.4); 7.1288 (1.7); 7.1149 (3.1); 7.1030 (1.7); 6.8461 (2.1); 6.8336 (3.7); 6.8214 (1.8); 6.7518 (4.1); 6.7385 (3.8); 6.3852 (1.3); 4.9219 (1.0); 4.9112 (0.8); 4.7372 (1.7); 4.7233 (1.7); 4.7152 (0.9); 4.6025 (1.5); 4.2560 (1.0); 4.2422 (2.0); 4.2290 (1.5); 4.1922 (2.2); 4.1872 (2.6); 4.1819 (2.8); 4.1752 (3.0); 4.1633 (1.5); 4.1581 (1.2); 4.0333 (1.4); 4.0005 (0.5); 3.9573 (1.1); 3.8994 (16.0); 3.3248 (1.0); 3.3082 (65.7); 3.3064 (72.7); 3.1736 (0.5); 3.1653 (0.5); 2.6128 (1.0); 2.5394 (0.4); 2.5179 (2.4); 2.5151 (2.8); 2.5031 (128.1); 2.5002 (175.8); 2.4974 (131.8); 2.4760 (0.7); 2.3844 (1.1); 2.1395 (0.7); 2.0927 (0.6); 2.0678 (0.7); 2.0593 (0.8); 2.0511 (1.3); 2.0446 (1.5); 2.0364 (1.7); 2.0308 (1.3); 2.0226 (1.3); 2.0060 (1.5); 1.2495 (0.4); 1.2358 (0.7); 0.7862 (10.0); 0.7739 (5.0); 0.7602 (0.7); 0.0050 (0.6); 0.0002 (19.5)
[0505] I-057: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0506] =7.3139 (1.1); 7.2975 (1.2); 7.1361 (0.3); 7.1184 (1.4); 7.1066 (3.2); 7.1011 (2.0); 7.0953 (1.5); 7.0903 (1.6); 7.0709 (2.0); 7.0653 (1.5); 7.0488 (0.9); 6.1783 (0.8); 6.1562 (0.8); 4.7353 (0.9); 4.6974 (0.8); 4.6877 (0.8); 4.5688 (1.8); 3.9826 (3.5); 3.9409 (0.8); 3.9016 (16.0); 3.8739 (0.6); 3.3199 (81.1); 2.7702 (0.3); 2.7449 (0.9); 2.7282 (1.4); 2.7150 (1.6); 2.6971 (1.6); 2.6839 (0.9); 2.6702 (1.0); 2.5054 (82.1); 2.5010 (108.5); 2.4966 (85.0); 2.3322 (0.5); 2.3276 (0.7); 2.3235 (0.6); 1.9290 (1.0); 1.9159 (1.5); 1.9066 (1.6); 1.8936 (0.9); 1.7998 (0.4); 1.7758 (0.8); 1.7541 (0.8); 1.6895 (2.7); 1.3323 (2.7); 1.3103 (1.8); 1.2583 (0.4); 1.2347 (0.4); 1.1730 (0.6); 0.0002 (12.0); 0.0083 (0.5)
[0507] I-058: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0508] =7.9551 (1.0); 7.9375 (1.1); 7.9341 (0.9); 7.6247 (0.6); 7.6063 (0.4); 7.5473 (0.4); 7.5406 (0.6); 7.5268 (1.6); 7.5042 (15.2); 7.4728 (0.7); 7.2669 (1.3); 7.2488 (1.4); 7.1365 (0.9); 7.1332 (1.0); 7.1157 (1.8); 7.0981 (1.1); 7.0947 (1.1); 6.8506 (1.2); 6.8323 (2.1); 6.8137 (1.0); 6.7545 (2.4); 6.7345 (2.1); 6.4351 (1.1); 6.4137 (1.1); 4.7205 (1.3); 4.6724 (0.5); 4.6632 (0.5); 4.6553 (0.4); 4.6458 (0.4); 4.5505 (0.4); 4.5344 (0.5); 4.5180 (0.4); 4.2593 (0.5); 4.2397 (1.0); 4.2328 (1.0); 4.2196 (1.0); 4.2131 (0.9); 4.1834 (1.1); 4.1731 (1.1); 4.1616 (0.6); 4.1564 (0.7); 4.1097 (0.4); 4.0968 (0.8); 4.0838 (0.9); 4.0704 (0.4); 4.0174 (3.1); 3.9016 (16.0); 3.8179 (0.4); 3.7907 (0.4); 3.3212 (102.5); 3.2673 (0.5); 3.1749 (3.4); 3.1620 (3.3); 2.7897 (0.4); 2.6747 (0.7); 2.6702 (0.9); 2.6657 (0.7); 2.5404 (0.8); 2.5099 (57.7); 2.5057 (110.8); 2.5012 (143.9); 2.4966 (108.3); 2.4925 (56.3); 2.3324 (0.6); 2.3281 (0.9); 2.3234 (0.7); 2.0093 (1.3); 1.2487 (0.3); 1.2354 (1.0); 0.0078 (0.6); 0.0003 (16.5); 0.0086 (0.7)
[0509] I-060: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0510] =7.3564 (0.3); 7.3430 (0.4); 7.3174 (1.0); 7.3080 (1.0); 7.1288 (0.7); 7.1177 (1.3); 7.1087 (2.3); 7.1059 (2.3); 7.0946 (1.3); 7.0856 (0.6); 7.0658 (1.5); 7.0540 (0.9); 6.1502 (0.5); 4.9162 (0.5); 4.6945 (0.7); 4.5973 (0.7); 4.1807 (0.6); 4.0341 (0.5); 4.0186 (0.7); 3.9468 (0.5); 3.8995 (16.0); 3.3251 (1.6); 3.3083 (79.4); 3.2678 (0.4); 3.1694 (1.6); 2.7645 (0.4); 2.7465 (0.6); 2.7351 (0.8); 2.7058 (0.6); 2.6952 (1.0); 2.6675 (0.5); 2.6119 (0.8); 2.5182 (1.8); 2.5152 (2.0); 2.5032 (105.0); 2.5003 (145.0); 2.4974 (108.2); 2.3843 (0.8); 2.1335 (0.5); 2.1073 (0.4); 1.9165 (1.2); 1.8960 (0.6); 1.8579 (0.5); 1.7779 (0.6); 1.7634 (0.6); 1.6904 (0.6); 1.6793 (0.5); 1.0154 (0.4); 1.0023 (0.8); 0.7858 (4.7); 0.7731 (2.5); 0.0002 (13.3)
[0511] 1H-NMR
[0512] I-061: .sup.1H-NMR(601.6MHz,d.sub.6-DMSO):
[0513] =7.3182 (1.1); 7.3078 (2.3); 7.2962 (1.5); 7.1275 (0.8); 7.1167 (2.3); 7.1054 (4.3); 7.0933 (2.0); 7.0812 (0.8); 7.0657 (2.9); 7.0542 (1.7); 6.1666 (1.0); 6.1508 (1.3); 6.1440 (1.7); 6.1282 (1.5); 4.6963 (1.4); 4.6678 (4.0); 4.5765 (5.6); 4.2698 (0.3); 4.0089 (1.4); 4.0009 (2.8); 3.9919 (2.0); 3.9283 (3.1); 3.9192 (4.9); 3.9113 (3.1); 3.8994 (16.0); 3.8896 (1.9); 3.8812 (1.8); 3.3058 (99.4); 3.1730 (0.4); 2.7734 (0.5); 2.7627 (0.6); 2.7449 (1.0); 2.7343 (1.4); 2.7052 (1.0); 2.6950 (1.8); 2.6938 (1.8); 2.6842 (1.0); 2.6659 (0.8); 2.6125 (0.8); 2.6092 (0.7); 2.5209 (1.8); 2.5179 (2.3); 2.5147 (2.5); 2.5029 (111.7); 2.4999 (155.7); 2.4970 (118.8); 2.3841 (1.0); 2.1388 (11.9); 2.1023 (7.9); 1.9274 (1.3); 1.9135 (2.3); 1.8973 (1.0); 1.7968 (0.4); 1.7686 (1.2); 1.7559 (1.0); 1.7419 (0.5); 1.7148 (0.6); 1.7046 (1.0); 1.6864 (1.1); 1.2371 (0.6); 0.0002 (16.3)
[0514] I-064: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0515] =8.6481 (1.8); 8.6395 (2.3); 8.0070 (1.0); 7.9875 (2.1); 7.9681 (1.2); 7.7273 (3.6); 7.7077 (3.2); 7.5692 (1.8); 7.5568 (1.9); 7.5520 (1.8); 7.5382 (1.6); 7.2828 (1.2); 7.2641 (1.4); 7.2482 (0.9); 7.2292 (0.8); 7.1375 (0.7); 7.1190 (1.5); 7.1098 (1.2); 7.1043 (1.2); 6.8574 (0.9); 6.8399 (2.0); 6.8224 (1.6); 6.8042 (0.5); 6.7598 (1.8); 6.7462 (1.4); 6.7405 (1.7); 6.7272 (1.1); 6.4565 (1.0); 6.4348 (1.1); 6.4059 (0.8); 6.3838 (0.7); 4.8150 (4.4); 4.7738 (3.2); 4.7592 (1.0); 4.7368 (0.9); 4.7226 (0.7); 4.7086 (0.6); 4.6978 (0.5); 4.6879 (0.5); 4.2716 (0.4); 4.2517 (1.0); 4.2439 (1.0); 4.2321 (1.0); 4.2242 (1.2); 4.1933 (1.5); 4.1834 (2.0); 4.1722 (2.3); 4.1584 (1.8); 4.0978 (0.6); 4.0844 (0.7); 4.0705 (0.4); 4.0428 (1.8); 4.0210 (2.3); 4.0084 (1.9); 3.9754 (2.0); 3.9634 (2.1); 3.9017 (16.0); 3.3229 (144.7); 3.2674 (0.6); 3.1751 (3.3); 3.1624 (3.2); 2.6752 (0.7); 2.6707 (1.0); 2.6661 (0.7); 2.5408 (0.9); 2.5238 (3.6); 2.5105 (65.8); 2.5061 (128.8); 2.5016 (168.8); 2.4971 (126.2); 2.4927 (64.8); 2.3328 (0.8); 2.3284 (1.0); 2.3239 (0.8); 2.3194 (0.4); 2.0665 (0.6); 2.0553 (0.8); 2.0241 (1.4); 2.0151 (1.4); 2.0000 (1.2); 1.2496 (0.3); 1.2356 (0.8); 0.0080 (0.7); 0.0002 (19.4); 0.0084 (0.8)
[0516] I-065: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0517] =8.1025 (0.3); 7.8896 (2.0); 7.8790 (3.5); 7.8381 (0.9); 7.8270 (0.9); 7.7465 (1.2); 7.7334 (1.8); 7.7201 (0.8); 7.2632 (0.7); 7.2530 (0.7); 7.1275 (0.8); 7.1134 (1.3); 7.1024 (0.8); 6.8441 (0.9); 6.8318 (1.3); 6.8202 (0.6); 6.7504 (1.5); 6.7371 (1.4); 6.4084 (0.6); 4.7920 (0.3); 4.7603 (0.5); 4.7303 (0.6); 4.2403 (0.7); 4.1782 (0.8); 4.1748 (0.8); 4.1617 (0.6); 4.0795 (0.5); 4.0715 (0.4); 4.0165 (1.7); 3.8996 (16.0); 3.7894 (0.4); 3.3254 (1.5); 3.3079 (101.6); 3.2682 (0.7); 3.1738 (1.6); 3.1652 (1.6); 2.6154 (0.5); 2.6122 (0.7); 2.6092 (0.6); 2.5215 (1.4); 2.5184 (1.7); 2.5152 (1.8); 2.5065 (46.9); 2.5035 (101.9); 2.5005 (141.3); 2.4974 (101.5); 2.4944 (47.1); 2.3877 (0.5); 2.3846 (0.8); 2.3815 (0.6); 2.0560 (0.4); 2.0306 (0.6); 2.0229 (0.6); 1.9992 (0.7); 1.8625 (0.5); 1.2353 (0.3); 0.0052 (0.3); 0.0002 (15.7); 0.0059 (0.6)
[0518] I-066: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0519] =7.6684 (0.4); 7.6340 (0.3); 7.5953 (0.4); 7.5678 (1.1); 7.5542 (13.7); 7.5415 (0.7); 7.5210 (0.3); 7.2751 (0.8); 7.2625 (1.0); 7.2232 (1.1); 7.2111 (1.8); 7.1846 (0.9); 7.1735 (1.6); 7.1616 (0.8); 7.1436 (1.0); 7.1323 (1.3); 7.1194 (0.5); 6.2595 (0.6); 6.2574 (0.6); 6.2436 (0.6); 5.0526 (0.5); 5.0478 (0.5); 4.7133 (0.4); 4.0799 (0.6); 4.0714 (0.6); 4.0089 (2.1); 3.8996 (16.0); 3.7918 (0.4); 3.7780 (0.4); 3.7681 (0.3); 3.5745 (0.3); 3.3251 (1.5); 3.3090 (111.0); 3.1737 (2.5); 3.1652 (2.4); 2.9344 (0.4); 2.9193 (0.4); 2.9092 (0.5); 2.8964 (0.5); 2.7805 (0.4); 2.7669 (0.7); 2.7537 (0.5); 2.7412 (0.5); 2.6152 (0.6); 2.6119 (0.8); 2.5212 (1.1); 2.5183 (1.4); 2.5152 (1.4); 2.5062 (54.4); 2.5034 (116.1); 2.5004 (160.8); 2.4975 (117.8); 2.4946 (57.3); 2.4460 (0.7); 2.4171 (0.5); 2.3878 (0.8); 2.3848 (1.0); 1.8293 (0.4); 1.8127 (0.5); 1.7953 (0.4); 0.0051 (0.4): 0.0002 (12.8)
[0520] I-067: .sup.1H-NMR(601.6 MHz. d.sub.6-DMSO):
[0521] =7.9467 (0.3); 7.9324 (0.4); 7.5745 (0.6); 7.5521 (16.0); 7.5356 (0.4); 7.2631 (1.0); 7.2499 (1.0); 7.1258 (0.9); 7.1141 (1.6); 7.1002 (0.9); 6.8429 (1.0); 6.8310 (1.8); 6.8188 (0.9); 6.7501 (2.0); 6.7367 (1.8); 6.4150 (0.9); 6.4031 (0.8); 4.7224 (1.0); 4.6749 (0.3); 4.6681 (0.3); 4.6490 (0.3); 4.2381 (0.9); 4.2230 (0.7); 4.1737 (0.8); 4.1591 (0.6); 4.0884 (0.4); 4.0799 (0.8); 4.0706 (0.8); 4.0627 (0.4); 4.0095 (2.5); 3.8995 (14.4); 3.3250 (1.3); 3.3074 (74.8); 3.2682 (0.6); 3.1738 (3.6); 3.1651 (3.5); 2.6120 (0.7); 2.5210 (1.2); 2.5183 (1.5); 2.5152 (1.7); 2.5032 (89.2); 2.5003 (122.3); 2.4974 (90.1); 2.3844 (0.7); 2.0451 (0.6); 2.0345 (0.7); 2.0157 (0.6); 2.0025 (0.8); 1.8624 (0.4); 1.2360 (0.5); 0.0002 (12.3)
[0522] 1H-NMR
[0523] I-068: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0524] =7.2649 (1.2); 7.2460 (1.3); 7.1347 (0.9); 7.1152 (1.8); 7.0969 (1.1); 6.8503 (1.2); 6.8317 (2.0); 6.8132 (1.0); 6.7549 (2.4); 6.7345 (2.2); 6.4180 (0.7); 6.3943 (1.6); 6.3714 (1.0); 4.7479 (0.5); 4.7349 (1.0); 4.7149 (1.0); 4.7005 (0.5); 4.6756 (2.8); 4.5836 (4.0); 4.2683 (0.4); 4.2600 (0.4); 4.2403 (1.0); 4.2338 (0.9); 4.2205 (0.9); 4.1989 (0.8); 4.1896 (1.1); 4.1834 (1.1); 4.1735 (1.1); 4.1624 (0.4); 4.1557 (0.6); 4.1466 (0.4); 4.0959 (0.3); 4.0833 (0.3); 4.0280 (0.8); 4.0149 (1.8); 4.0023 (1.3); 3.9351 (1.9); 3.9213 (3.1); 3.9117 (2.9); 3.9015 (16.0); 3.3213 (95.3); 3.2672 (0.5); 3.1748 (1.5); 3.1619 (1.5); 2.6748 (0.4); 2.6701 (0.6); 2.6657 (0.4); 2.5402 (0.4); 2.5234 (2.1); 2.5100 (38.6); 2.5057 (76.0); 2.5011 (99.8); 2.4966 (75.2); 2.4922 (38.9); 2.3325 (0.5); 2.3280 (0.6); 2.3236 (0.5); 2.1409 (8.9); 2.1031 (5.9); 2.0754 (0.3); 2.0630 (0.4); 2.0503 (0.7); 2.0391 (0.9); 2.0295 (1.1); 2.0183 (1.3); 2.0092 (1.2); 1.9957 (0.9); 1.9792 (0.6); 1.9683 (0.4); 0.0080 (0.4); 0.0002 (12.4); 0.0084 (0.5)
[0525] I-073: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0526] =8.6463 (1.4); 8.6393 (1.9); 7.9992 (0.9); 7.9860 (1.5); 7.7224 (2.7); 7.7094 (2.6); 7.5615 (1.4); 7.5528 (1.5); 7.5502 (1.5); 7.5410 (1.2); 7.3304 (0.8); 7.3178 (0.9); 7.2929 (0.6); 7.2814 (0.7); 7.1208 (1.2); 7.1120 (2.2); 7.0991 (1.7); 7.0850 (0.7); 7.0713 (1.2); 7.0589 (1.4); 6.2088 (0.7); 6.1938 (0.8); 6.1569 (0.5); 6.1420 (0.6); 4.8075 (3.2); 4.7635 (2.1); 4.7127 (0.6); 4.6809 (0.4); 4.6679 (0.5); 4.1692 (1.2); 4.1610 (0.8); 4.0302 (1.3); 4.0054 (1.6); 3.9678 (1.5); 3.9599 (1.7); 3.8996 (16.0); 3.3344 (0.6); 3.3253 (1.7); 3.3090 (117.1); 3.2679 (0.4); 3.1694 (0.7); 2.7513 (0.6); 2.7334 (0.7); 2.7128 (0.6); 2.7002 (0.8); 2.6737 (0.6); 2.6654 (0.4); 2.6124 (0.9); 2.6091 (0.8); 2.5215 (1.3); 2.5185 (1.7); 2.5153 (1.6); 2.5063 (52.1); 2.5034 (113.2); 2.5004 (158.0); 2.4974 (115.3); 2.4945 (55.1); 2.3877 (0.7); 2.3846 (0.9); 1.9439 (0.5); 1.9269 (0.9); 1.8979 (1.0); 1.8583 (0.4); 1.7907 (0.6); 1.7751 (0.8); 1.7595 (0.7); 1.7458 (0.4); 1.7299 (0.4); 1.7088 (0.6); 1.6963 (0.6); 1.6890 (0.6); 1.6605 (0.4); 0.0002 (15.1)
[0527] I-076: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0528] =7.4139 (1.6); 7.4097 (2.0); 7.4040 (2.8); 7.3979 (3.2); 7.3908 (0.7); 7.3817 (1.4); 7.3760 (7.5); 7.3715 (5.2); 7.3684 (2.3); 7.3652 (3.0); 7.2679 (1.6); 7.2564 (1.6); 7.1311 (0.9); 7.1285 (0.9); 7.1173 (1.6); 7.1058 (1.0); 7.1027 (1.0); 6.8496 (1.2); 6.8478 (1.3); 6.8356 (2.0); 6.8250 (1.1); 6.8231 (1.0); 6.7539 (2.3); 6.7402 (2.0); 6.7385 (2.0); 6.4168 (1.7); 6.4025 (1.7); 4.7342 (0.5); 4.7261 (1.0); 4.7170 (0.8); 4.7106 (1.0); 4.7019 (0.5); 4.6232 (9.2); 4.3574 (6.5); 4.2625 (0.4); 4.2580 (0.6); 4.2490 (0.6); 4.2443 (1.2); 4.2396 (0.9); 4.2306 (0.8); 4.2258 (0.8); 4.1971 (0.7); 4.1914 (0.8); 4.1861 (0.8); 4.1797 (1.0); 4.1732 (0.5); 4.1679 (0.5); 4.1618 (0.4); 3.8992 (16.0); 3.8684 (1.4); 3.8600 (2.7); 3.8510 (1.7); 3.6377 (2.0); 3.6284 (3.1); 3.6195 (1.7); 3.3083 (94.7); 3.1737 (1.2); 3.1650 (1.2); 2.6148 (0.4); 2.6121 (0.7); 2.6089 (0.5); 2.5212 (1.2); 2.5182 (1.5); 2.5151 (1.5); 2.5062 (39.5); 2.5032 (87.2); 2.5002 (122.5); 2.4972 (88.7); 2.4942 (42.0); 2.3878 (0.5); 2.3843 (0.8); 2.0612 (0.4); 2.0518 (0.7); 2.0463 (0.8); 2.0378 (0.9); 2.0295 (0.7); 2.0242 (0.4); 2.0177 (0.4); 2.0118 (0.6); 2.0057 (0.8); 2.0015 (0.9); 1.9903 (0.6); 1.9835 (0.4); 1.9783 (0.4); 1.9731 (0.3); 0.0002 (13.1); 0.0059 (0.6)
[0529] I-078: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0530] =7.4141 (1.2); 7.4096 (1.4); 7.4041 (1.9); 7.3981 (2.4); 7.3919 (0.6); 7.3821 (1.1); 7.3764 (5.4); 7.3717 (3.9); 7.3655 (2.6); 7.3181 (1.1); 7.3064 (1.1); 7.1316 (0.4); 7.1226 (1.0); 7.1195 (1.1); 7.1117 (2.1); 7.1089 (1.9); 7.1012 (1.0); 7.0981 (1.1); 7.0889 (0.4); 7.0702 (1.3); 7.0670 (1.2); 7.0555 (0.7); 6.1949 (1.5); 6.1796 (1.6); 4.7030 (0.4); 4.6911 (0.6); 4.6814 (0.6); 4.6677 (0.4); 4.6211 (7.1); 4.3509 (5.3); 3.8992 (16.0); 3.8558 (1.2); 3.8473 (2.3); 3.8385 (1.3); 3.6343 (1.6); 3.6252 (2.4); 3.6163 (1.3); 3.3251 (0.8); 3.3073 (84.6); 2.7478 (0.5); 2.7383 (0.6); 2.7273 (0.4); 2.7074 (0.4); 2.6968 (0.8); 2.6878 (0.4); 2.6695 (0.4); 2.6148 (0.4); 2.6120 (0.6); 2.5211 (1.0); 2.5181 (1.2); 2.5150 (1.2); 2.5062 (34.3); 2.5031 (75.9); 2.5001 (106.4); 2.4970 (76.0); 2.4940 (35.2); 2.3872 (0.4); 2.3843 (0.6); 2.3810 (0.5); 1.9454 (0.3); 1.9327 (0.5); 1.9187 (1.0); 1.9125 (0.6); 1.9027 (0.4); 1.8882 (0.3); 1.7769 (0.7); 1.7610 (0.6); 1.7491 (0.4); 1.7105 (0.4); 1.6954 (0.4); 1.6821 (0.4); 1.6787 (0.4); 0.0053 (0.3); 0.0002 (13.2); 0.0057 (0.5)
[0531] 1H-NMR
[0532] I-079: .sup.1H-NMR(601.6 MHz, d.sub.6-DMSO):
[0533] =7.4176 (1.5); 7.4129 (1.7); 7.4076 (2.4); 7.4015 (2.9); 7.3848 (1.3); 7.3790 (6.2); 7.3743 (4.6); 7.3683 (2.9); 7.2764 (1.5); 7.2651 (1.8); 7.2280 (1.3); 7.2160 (2.0); 7.1904 (1.0); 7.1779 (1.8); 7.1663 (1.0); 7.1515 (1.2); 7.1399 (1.6); 7.1283 (0.5); 5.0584 (0.8); 5.0459 (1.5); 5.0330 (0.7); 4.6260 (8.5); 4.3637 (5.2); 3.8993 (16.0); 3.8709 (1.3); 3.8625 (2.5); 3.8538 (1.5); 3.6661 (0.4); 3.6403 (2.3); 3.6314 (3.3); 3.6225 (2.2); 3.5220 (3.8); 3.3998 (0.7); 3.3778 (0.4); 3.3713 (0.4); 3.3251 (0.7); 3.1695 (2.6); 2.9429 (0.4); 2.9382 (0.4); 2.9296 (0.5); 2.9240 (0.5); 2.9170 (0.7); 2.9126 (0.6); 2.9033 (0.6); 2.8979 (0.6); 2.8904 (0.6); 2.7862 (0.5); 2.7718 (1.0); 2.7589(0.8); 2.7464 (0.7); 2.7317 (0.8); 2.6151 (0.6); 2.6123 (0.7); 2.6094 (0.6); 2.5584 (0.4); 2.5490 (1.0); 2.5397 (0.9); 2.5214 (1.4); 2.5185 (1.6); 2.5153 (1.6); 2.5065 (45.3); 2.5035 (98.9); 2.5005 (137.8); 2.4975 (99.8); 2.4945 (47.5); 2.4708 (0.7); 2.4655 (0.6); 2.4576 (0.7); 2.4529 (0.9); 2.4449 (0.9); 2.4370 (0.8); 2.4318 (0.8); 2.4248 (0.5); 2.4191 (0.4); 2.3849 (0.8); 2.3820 (0.6); 1.8498 (0.4); 1.8358 (0.9); 1.8295 (0.4); 1.8219 (0.8); 1.8153 (0.9); 1.8077 (0.4); 1.8015 (0.8); 0.0002 (8.8)
[0534] I-084: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0535] =8.3177 (0.3); 7.2681 (3.0); 7.2497 (3.3); 7.1385 (5.0); 7.1351 (5.1); 7.1185 (5.6); 7.1004 (3.1); 7.0969 (2.8); 6.8497 (2.2); 6.8314 (3.8); 6.8128 (1.8); 6.7777 (0.6); 6.7580 (4.2); 6.7378 (3.8); 6.4639 (2.1); 6.4419 (2.1); 4.7574 (0.8); 4.7439 (1.8); 4.7328 (1.4); 4.7223 (1.8); 4.7090 (0.8); 4.4571 (9.7); 4.2726 (0.6); 4.2649 (0.8); 4.2448 (2.0); 4.2376 (1.6); 4.2251 (1.6); 4.2174 (1.4); 4.2023 (1.4); 4.1933 (1.7); 4.1867 (1.7); 4.1773 (1.8); 4.1665 (0.7); 4.1594 (0.9); 4.1506 (0.6); 4.1011 (0.4); 4.0883 (0.5); 4.0750 (0.4); 4.0574 (2.5); 4.0441 (4.8); 4.0308 (3.0); 3.9021 (16.0); 3.7881 (3.6); 3.7743 (5.7); 3.7609 (2.9); 3.3231 (93.2); 3.1745 (1.7); 3.1614 (1.6); 2.8051 (0.6); 2.7878 (1.4); 2.7799 (1.1); 2.7735 (2.4); 2.7674 (1.1); 2.7571 (1.6); 2.7417 (0.6); 2.6752 (1.1); 2.6708 (1.5); 2.6662 (1.1); 2.5061 (199.3); 2.5018 (255.5); 2.4975 (190.0); 2.3327 (1.1); 2.3285 (1.5); 2.3241 (1.2); 2.0817 (0.5); 2.0703 (0.6); 2.0571 (1.1); 2.0460 (1.4); 2.0362 (1.6); 2.0253 (2.0); 2.0157 (1.9); 2.0102 (1.8); 2.0014 (1.8); 1.9873 (1.0); 1.9752 (0.7); 1.9674 (0.5); 1.9599 (0.4); 1.8905 (0.5); 1.8778 (0.9); 1.8700 (1.0); 1.8579 (1.6); 1.8493 (0.7); 1.8452 (1.0); 1.8374 (1.0); 1.8247 (0.5); 1.2368 (0.5); 1.0138 (15.1); 1.0021 (7.2); 0.9942 (6.6); 0.9047 (0.7); 0.8973 (0.8); 0.8847 (1.9); 0.5708 (0.7); 0.5592 (2.3); 0.5541 (3.6); 0.5467 (3.3); 0.5420 (3.5); 0.5341 (1.4); 0.5251 (0.6); 0.5125 (1.4); 0.5048 (3.1); 0.4999 (2.3); 0.4922 (1.6); 0.4846 (3.1); 0.4791 (1.9); 0.4718 (0.7); 0.4670 (0.6); 0.0001 (6.4)
[0536] I-087: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0537] =7.3441 (0.3); 7.3130 (0.8); 7.2939 (1.9); 7.2848 (2.1); 7.1582 (2.2); 7.1205 (1.0); 7.1078 (1.7); 7.0949 (1.0); 7.0902 (1.0); 7.0722 (1.3); 7.0668 (1.1); 7.0496 (1.3); 7.0323 (2.0); 6.7784 (0.9); 4.7062 (0.4); 4.6952 (0.4); 4.4471 (1.6); 4.0335 (1.1); 3.9019 (16.0); 3.7847 (1.0); 3.7706 (1.5); 3.7576 (0.8); 3.3237 (37.0); 3.1670 (1.2); 2.7860 (0.5); 2.7713 (0.8); 2.7555 (0.6); 2.7302 (0.5); 2.7158 (0.6); 2.6979 (0.6); 2.6805 (0.5); 2.6754 (0.7); 2.6710 (0.9); 2.6666 (0.7); 2.5064 (107.2); 2.5020 (137.6); 2.4975 (103.4); 2.3332 (0.7); 2.3288 (0.9); 2.3242 (0.7); 1.9353 (0.5); 1.9219 (0.7); 1.9111 (0.7); 1.8945 (0.6); 1.8818 (0.8); 1.8743 (0.8); 1.8624 (1.1); 1.8493 (0.7); 1.8416 (0.6); 1.8292 (0.3); 1.7768 (0.4); 1.7530 (0.4); 1.7106 (0.3); 1.6932 (0.3); 1.4256 (0.3); 1.0125 (4.4); 0.9979 (2.3); 0.9037(1.1); 0.8968 (1.2); 0.8845 (3.3); 0.5733 (0.5); 0.5607 (1.5); 0.5564 (2.3); 0.5486 (2.2); 0.5444 (2.3); 0.5366 (0.9); 0.5278 (0.4); 0.5155 (1.0); 0.5076 (2.1); 0.5032 (1.5); 0.4951 (1.1); 0.4875 (2.1); 0.4827 (1.2); 0.4748 (0.5); 0.4704 (0.5); 0.0080 (0.4); 0.0002 (12.1); 0.0084 (0.5)
[0538] I-088: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0539] =7.2749 (1.2); 7.2573 (1.6); 7.2319 (0.9); 7.2137 (2.0); 7.1936 (0.9); 7.1779 (1.6); 7.1602 (1.0); 7.1520 (1.2); 7.1334 (1.3); 7.1154 (0.5); 5.0785 (0.6); 5.0596 (1.2); 5.0402 (0.6); 4.4609 (4.2); 4.1073 (0.4); 4.0579 (1.5); 4.0455 (2.6); 4.0325 (1.7); 3.9749 (0.4); 3.9635 (0.4); 3.9016 (16.0); 3.7915 (1.8); 3.7778 (2.8); 3.7641 (1.5); 3.1684 (0.9); 2.9485 (0.3); 2.9343 (0.4); 2.9261 (0.4); 2.9164 (0.5); 2.9086 (0.6); 2.8907 (0.8); 2.7947 (0.8); 2.7765 (2.0); 2.7593 (1.3); 2.7385(0.6); 2.7315 (0.5); 2.6751 (0.4); 2.6705 (0.6); 2.6660 (0.4); 2.5237 (1.6); 2.5059 (85.8); 2.5015 (110.3); 2.4970 (82.5); 2.4645 (1.3); 2.4559 (1.2); 2.4448 (1.1); 2.4332 (1.0); 2.4252 (0.9); 2.4142 (0.6); 2.4059 (0.5); 2.3324 (0.6); 2.3282 (0.8); 2.3236 (0.6); 1.8429 (0.7); 1.8338 (0.4); 1.8219 (0.7); 1.8118 (0.7); 1.8006 (0.4); 1.7911 (0.7); 1.0159 (7.3); 1.0038 (3.4); 0.9968 (3.3); 0.0002 (9.3); 0.0083 (0.4)
[0540] 1H-NMR
[0541] I-091: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0542] =7.2681 (2.0); 7.2495 (2.2); 7.1353 (1.0); 7.1169 (2.1); 7.0990 (1.2); 6.8528 (1.4); 6.8340 (2.5); 6.8159 (1.2); 6.7570 (2.7); 6.7366 (2.4); 6.4543 (1.8); 6.4324 (1.9); 4.7481 (0.6); 4.7337 (1.2); 4.7241 (1.1); 4.7132 (1.2); 4.7002 (0.6); 4.4760 (7.3); 4.2680 (0.4); 4.2609 (0.6); 4.2411 (1.4); 4.2333 (1.1); 4.2214 (1.1); 4.2136 (1.0); 4.1995 (0.9); 4.1906 (1.2); 4.1849 (1.2); 4.1750 (1.2); 4.1629 (0.5); 4.1576 (0.6); 4.1494 (0.4); 3.9958 (1.8); 3.9827 (3.6); 3.9698 (2.3); 3.9017 (9.5); 3.8168 (2.4); 3.8034 (3.7); 3.7908 (1.8); 3.5716 (0.5); 3.5544 (1.2); 3.5374 (1.6); 3.5205 (1.2); 3.5038 (0.5); 3.3193 (37.1); 3.1746 (0.8); 3.1616 (0.8); 2.6702 (0.7); 2.5013 (125.0); 2.3285 (0.8); 2.0766 (0.3); 2.0676 (0.4); 2.0534 (0.7); 2.0421 (1.0); 2.0317 (1.2); 2.0230 (1.4); 2.0107 (1.6); 2.0012 (1.3); 1.9754 (0.5); 1.7163 (1.1); 1.7040 (1.1); 1.3383 (0.3); 1.2599 (16.0); 1.2430 (15.8); 0.0002 (7.4)
[0543] I-094: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0544] =7.3174 (1.3); 7.3014 (1.6); 7.2961 (1.6); 7.1380 (0.4); 7.1242 (1.2); 7.1201 (1.5); 7.1152 (1.5); 7.1089 (3.7); 7.1026 (2.2); 7.0974 (1.6); 7.0926 (1.7); 7.0726 (2.1); 7.0665 (1.6); 7.0506 (1.0); 6.2324 (1.8); 6.2094 (1.8); 4.7166 (0.4); 4.6988 (0.8); 4.6870 (0.9); 4.6660 (0.5); 4.4683 (7.1); 3.9831 (1.5); 3.9700 (3.2); 3.9566 (2.0); 3.9013 (12.3); 3.8135 (2.1); 3.8002 (3.3); 3.7869 (1.6); 3.5694 (0.4); 3.5522 (1.2); 3.5352 (1.6); 3.5184 (1.2); 3.5015 (0.5); 3.3183 (31.9); 3.1751 (0.6); 3.1628 (0.6); 2.7476 (0.7); 2.7298 (1.1); 2.7158 (1.1); 2.6988 (1.2); 2.6835 (0.6); 2.6705 (0.8); 2.6610 (0.5); 2.5056 (81.3); 2.5013 (103.0); 2.4971 (77.8); 2.3280 (0.7); 2.3240 (0.5); 1.9333 (1.0); 1.9203 (1.6); 1.9097 (1.6); 1.8948 (0.9); 1.8763 (0.5); 1.8576 (0.4); 1.8046 (0.4); 1.7770 (1.0); 1.7572 (0.9); 1.7347 (0.6); 1.7260 (0.5); 1.7040 (0.8); 1.6937 (0.8); 1.6697 (0.5); 1.2606 (16.0); 1.2437 (15.8); 0.0002 (6.8)
[0545] I-095: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0546] =7.6779 (0.4); 7.6511 (0.4); 7.2736 (0.8); 7.2563 (1.0); 7.2303 (0.7); 7.2127 (1.2); 7.1930 (0.6); 7.1773 (1.0); 7.1549 (0.9); 7.1359 (0.8); 5.0510 (0.6); 4.4787 (2.8); 4.4316 (0.7); 3.9959 (0.8); 3.9826 (1.5); 3.9698 (1.0); 3.9169 (0.5); 3.9018 (16.0); 3.8208 (1.1); 3.8072 (1.7); 3.7941 (1.0); 3.7833 (0.6); 3.7690 (0.6); 3.5856 (0.4); 3.5735 (0.6); 3.5564 (1.0); 3.5474 (0.7); 3.5395 (1.4); 3.5222 (1.4); 3.5040 (1.4); 3.4066 (16.3); 3.1685 (1.7); 2.9122 (0.3); 2.9051 (0.4); 2.8906 (0.6); 2.8836 (0.3); 2.7758 (0.4); 2.7320 (0.3); 2.6711 (0.7); 2.5240 (1.6); 2.5063 (107.2); 2.5020 (137.8); 2.4977 (104.6); 2.4561 (1.3); 2.4440 (1.0); 2.4336 (1.0); 2.4255 (0.8); 2.4133 (0.6); 2.4065 (0.6); 2.3838 (0.4); 2.3690 (0.3); 2.3330 (0.8); 2.3286 (1.0); 2.3241 (0.8); 1.8811 (0.4); 1.8368 (0.4); 1.8160 (0.5); 1.8058 (0.4); 1.7849 (0.4); 1.4260 (0.4); 1.3655 (0.7); 1.3487 (1.0); 1.3322 (0.4); 1.2612 (7.8); 1.2442 (9.9); 1.2267 (2.8); 1.1912 (0.5); 1.1786 (0.7); 1.1630 (0.6); 1.1494 (0.5); 1.1321 (0.5); 1.0623 (0.4); 1.0455 (0.4); 0.0001 (7.8)
[0547] I-096: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0548] =7.2748 (1.3); 7.2573 (1.8); 7.2309 (1.0); 7.2138 (2.2); 7.1938 (1.0); 7.1777 (1.8); 7.1547 (1.5); 7.1343 (1.4); 7.1174 (0.5); 5.0754 (0.6); 5.0566 (1.3); 5.0378 (0.7); 4.4061 (4.2); 4.0558 (1.4); 4.0439 (2.5); 4.0315 (1.7); 3.9636 (0.5); 3.9018 (10.0); 3.8803 (0.7); 3.8691 (0.7); 3.7166 (2.2); 3.7031 (3.2); 3.6897 (1.9); 3.1685 (0.8); 3.0767 (16.0); 2.9527 (0.4); 2.9459 (0.4); 2.9314 (0.4); 2.9237 (0.4); 2.9141 (0.7); 2.9064 (0.7); 2.8914 (0.8); 2.8850 (0.6); 2.7977 (0.5); 2.7771 (1.0); 2.7569 (0.8); 2.7382 (0.6); 2.7173 (0.4); 2.6753 (0.5); 2.6707 (0.6); 2.6664 (0.5); 2.5061 (89.7); 2.5018 (114.2); 2.4974 (86.1); 2.4653 (1.3); 2.4569 (1.1); 2.4454 (1.0); 2.4341 (1.0); 2.4263 (0.8); 2.4150 (0.5); 2.4068 (0.4); 2.3284 (0.7); 1.8400 (0.8); 1.8306 (0.4); 1.8192 (0.8); 1.8098 (0.7); 1.7978 (0.4); 1.7882 (0.7); 1.2359 (0.4); 0.0001 (8.4)
[0549] I-097: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0550] =7.3175 (1.1); 7.3012 (1.3); 7.2961 (1.3); 7.1384 (0.3); 7.1251 (1.0); 7.1205 (1.2); 7.1154 (1.2); 7.1092 (3.0); 7.1033 (1.8); 7.0974 (1.3); 7.0924 (1.5); 7.0731 (1.8); 7.0671 (1.4); 7.0555 (0.8); 7.0508 (0.8): 6.2463 (1.2); 6.2232 (1.2); 4.7036 (0.6); 4.6929 (0.8); 4.6699 (0.4); 4.3964 (5.6); 4.0411 (1.4); 4.0284 (2.5); 4.0153 (1.5); 3.9017 (12.7); 3.7095 (1.8); 3.6956 (2.8); 3.6823 (1.5); 3.3202 (35.2); 3.0968 (0.4); 3.0727 (16.0); 3.0283 (0.3); 2.7482 (0.6); 2.7298 (0.9); 2.7164 (0.9); 2.6996 (1.0); 2.6852 (0.5); 2.6747 (0.6); 2.6703 (0.8); 2.6656 (0.6); 2.6607 (0.4); 2.5233 (1.6); 2.5097 (41.5); 2.5056 (81.4); 2.5011 (105.8); 2.4966 (78.9); 2.3323 (0.5); 2.3278 (0.7); 2.3235 (0.6); 1.9363 (0.9); 1.9222 (1.4); 1.9111 (1.3); 1.8966 (0.7); 1.8789 (0.4); 1.8574 (0.4); 1.8058 (0.3); 1.7778 (0.8); 1.7551 (0.7); 1.7351 (0.6); 1.7297 (0.4); 1.7112 (0.6); 1.6952 (0.6); 1.6726 (0.4); 0.0002 (6.7)
[0551] 1H-NMR
[0552] I-105: .sup.1H-NMR(400.0MHz, d.sub.6-DMSO):
[0553] =8.1083 (1.4); 8.0898 (1.3); 7.7486 (0.4); 7.7367 (2.9); 7.7353 (3.0); 7.7288 (2.2); 7.7235 (1.6); 7.7202 (1.3); 7.6250 (0.7); 7.6172 (0.7); 7.6111 (0.6); 7.6047 (1.0); 7.5984 (0.7); 7.5905 (0.5); 7.5835 (0.5); 7.3016 (0.8); 7.2856 (1.0); 7.2801 (1.0); 7.1222 (0.8); 7.1177 (1.0); 7.1137 (1.0); 7.1069 (2.3); 7.1004 (1.3); 7.0960 (1.0); 7.0905 (1.0); 7.0775 (0.4); 7.0686 (1.2); 7.0624 (1.0); 7.0467 (0.6); 6.2468 (1.0); 6.2239 (1.0); 4.6714 (0.6); 4.5054 (4.0); 3.9019 (16.0); 3.8575 (1.6); 3.8454 (1.7); 3.3203 (35.7); 2.7415 (0.4); 2.7243 (0.6); 2.7109 (0.7); 2.6930 (0.8); 2.6754 (0.7); 2.6703 (0.7); 2.6662 (0.6); 2.5058 (70.2); 2.5014 (89.5); 2.4969 (66.5); 2.3325 (0.4); 2.3279 (0.5); 2.3237 (0.4); 1.9088 (0.9); 1.9005 (1.0); 1.8869 (0.6); 1.7628 (0.6); 1.7445 (0.6); 1.7205 (0.5); 1.7054 (0.4); 1.6842 (0.4); 1.6821 (0.4); 0.0002 (6.3)
[0554] I-106: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0555] =8.1129 (1.9); 8.0935 (1.8); 7.7506 (0.4); 7.7380 (4.2); 7.7309 (3.0); 7.7264 (2.3); 7.7233 (1.9); 7.7027 (0.3); 7.6275 (1.0); 7.6193 (1.0); 7.6140 (0.8); 7.6071 (1.3); 7.6005 (0.9); 7.5933 (0.7); 7.5861 (0.7); 7.2572 (1.3); 7.2392 (1.8); 7.2267 (1.0); 7.2092 (2.1); 7.1910 (0.9); 7.1757 (1.7); 7.1539 (1.8); 7.1350 (1.3); 7.1170 (0.4); 5.0532 (0.7); 5.0344 (1.4); 5.0153 (0.7); 4.5209 (5.1); 3.9020 (16.0); 3.8636 (3.6); 3.8515 (3.7); 3.1686 (1.0); 2.9461 (0.4); 2.9381 (0.4); 2.9248 (0.4); 2.9161 (0.4); 2.9075 (0.6); 2.8991 (0.6); 2.8852 (0.6); 2.8778 (0.6); 2.7896 (0.4); 2.7687 (1.0); 2.7485 (0.8); 2.7296 (0.6); 2.7088 (0.3); 2.6749 (0.5); 2.6706 (0.8); 2.6665 (0.6); 2.5060 (102.7); 2.5017 (132.8); 2.4974 (100.5); 2.4625 (0.9); 2.4509 (1.0); 2.4426 (0.9); 2.4315 (0.9); 2.4202 (0.9); 2.4122 (0.8); 2.4011 (0.5); 2.3930 (0.4); 2.3283 (0.8); 1.8281 (0.8); 1.8185 (0.4); 1.8071 (0.8); 1.7971 (0.8); 1.7860 (0.4); 1.7761 (0.7); 0.0001 (7.8 )
[0556] I-150: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0557] =8.0734 (3.0); 8.0545 (3.8); 7.7066 (3.2); 7.7028 (6.0); 7.6936 (8.6); 7.6920 (7.9); 7.6827 (0.9); 7.6100 (0.4); 7.5989 (1.8); 7.5899 (1.8); 7.5861 (1.8); 7.5788 (2.3); 7.5678 (2.1); 7.5574 (1.3); 7.3730 (3.9); 7.3516 (10.7); 7.3270 (11.9); 7.3106 (1.8); 7.3055 (4.3); 6.6022 (2.4); 6.5812 (2.5); 4.6352 (0.4); 4.6192 (1.5); 4.6000 (1.9); 4.5810 (1.4); 4.5639 (0.4); 4.4421 (9.7); 3.9021 (16.0); 3.8023 (3.4); 3.7949 (4.5); 3.7800 (5.1); 3.7762 (5.2); 3.3225 (139.5); 2.6752 (0.8); 2.6708 (1.2); 2.6663 (0.9); 2.5239 (4.1); 2.5106 (74.5); 2.5063 (145.5); 2.5018 (189.4); 2.4972 (142.1); 2.4932 (74.7); 2.3329 (0.8); 2.3285 (1.1); 2.3240 (0.8); 1.3511 (9.9); 1.3338 (9.9); 0.0080 (0.4); 0.0002 (12.2); 0.0084 (0.6)
[0558] I-151: .sup.1H-NMR(599.8 MHz, CDCl3):
[0559] =7.2623 (12.6); 7.0953 (14.4); 7.0605 (6.9); 7.0480 (9.7); 6.9935 (9.0); 6.9810 (6.2); 5.2973 (2.7); 4.7937 (3.8); 4.7786 (7.5); 4.7635 (4.1); 4.2471 (5.9); 4.2310 (5.6); 4.0188 (8.3); 4.0104 (15.5); 4.0019 (8.8); 3.7596 (1.0); 3.7320 (26.0); 3.7051 (1.0); 3.3146 (0.3); 3.3063 (0.6); 3.2977 (0.3); 3.0180 (4.0); 3.0054 (4.7); 2.9926 (5.4); 2.9776 (15.6); 2.9681 (13.6); 2.9569 (7.1); 2.9451 (4.6); 2.9343 (1.9); 2.4926 (3.7); 2.4772 (4.3); 2.4674 (3.5); 2.4518 (3.8); 2.3913 (0.3); 2.2881 (49.3); 2.2529 (0.6); 2.2408 (1.8); 2.2287 (3.6); 2.2160 (4.5); 2.2034 (3.4); 2.1909 (1.5); 2.1799 (0.6); 2.1699 (0.6); 1.7155 (13.4); 1.3263 (0.4); 1.3150 (0.5); 1.2854 (25.9); 1.2746 (25.5); 1.2500 (0.8); 1.2368 (0.6); 1.1458 (49.8); 1.1352 (50.0); 1.0396 (0.3); 1.0289 (0.3); 0.0001 (11.6)
[0560] I-152: .sup.1H-NMR(400.0 MHz, CDCl3):
[0561] =7.2598 (72.1); 7.0975 (2.2); 7.0662 (1.3); 7.0474 (2.0); 6.9958 (1.8); 6.9787 (0.9); 5.2978 (3.8); 4.8064 (0.7); 4.7838 (1.2); 4.7615 (0.8); 4.1899 (0.9); 4.1661 (0.9); 4.0307 (1.5); 4.0170 (2.8); 4.0034 (1.7); 3.7442 (4.8); 3.0302 (0.8); 3.0117(1.0); 2.9921 (2.4); 2.9818 (2.5); 2.9764 (3.6); 2.9680(1.5); 2.9633 (1.6); 2.9601 (1.8); 2.9435 (1.1); 2.5039 (0.7); 2.4807 (0.7); 2.4654 (0.6); 2.4435 (0.7); 2.2892 (9.9); 2.2341 (0.6); 2.2159 (0.8); 2.1987(0.6); 1.5736 (4.4); 1.2900 (8.3); 1.2732 (8.1); 1.1524 (16.0); 1.1360 (15.8); 0.0079 (1.0); 0.0002 (26.7); 0.0085 (1.1)
[0562] 1H-NMR
[0563] I-153: .sup.1H-NMR(400.0 MHz, CDCl3):
[0564] =7.5192 (0.6); 7.3979 (2.4); 7.3809 (3.0); 7.2602 (112.3); 7.2434 (4.7); 7.2399 (5.8); 7.2372 (4.5); 7.2277 (5.2); 7.2249 (4.2); 7.2159 (3.1); 7.2111 (2.6); 7.2069 (2.3); 7.1986 (2.2); 7.1922 (1.5); 7.1824 (1.0); 7.1761 (0.6); 6.9962 (0.6); 5.2977 (10.6); 5.2550 (0.8); 5.2361 (1.8); 5.2158 (1.8); 5.1965 (0.8); 4.3103 (1.4); 4.2880 (1.3); 4.0298 (16.0); 4.0126 (3.8); 3.9993 (6.6); 3.9849 (4.1); 3.3208 (6.2); 3.3068 (8.5); 3.2932 (5.8); 3.0219 (0.8); 3.0130 (0.8); 3.0005 (0.8); 2.9913 (0.9); 2.9823 (1.4); 2.9733 (1.6); 2.9608 (1.5); 2.9519 (1.5); 2.8957 (1.1); 2.8747 (2.3); 2.8549 (1.8); 2.8354 (1.2); 2.8154 (0.8); 2.7229 (1.1); 2.7139 (1.1); 2.7050 (1.3); 2.6960 (1.4); 2.6913 (1.4); 2.6855 (1.1); 2.6822 (1.3); 2.6764 (1.1); 2.6734 (1.4); 2.6643 (1.4); 2.6538 (1.0); 2.6447 (0.9); 1.9009 (1.0); 1.8797 (2.2); 1.8693 (1.1); 1.8610 (2.2); 1.8585 (1.3); 1.8505 (1.3); 1.8481 (2.0); 1.8396 (1.1); 1.8293 (2.0); 1.8268 (1.1); 1.8079 (0.9); 1.6369 (4.7); 0.0079 (1.5); 0.0002 (41.1); 0.0085 (1.5)
[0565] I-154: .sup.1H-NMR(400.0 MHz, CDCl3):
[0566] =7.5187 (0.7); 7.4546 (2.1); 7.4392 (2.3); 7.4317 (2.3); 7.2598 (126.5); 7.1838 (0.6); 7.1711 (2.7); 7.1664 (4.4); 7.1574 (8.1); 7.1487 (5.5); 7.1431 (3.0); 7.1308 (0.7); 7.1029 (2.7); 7.0947 (2.2); 7.0804 (1.5); 6.9958 (0.7); 4.8784 (0.8); 4.8642 (1.3); 4.8561 (1.1); 4.8438 (1.4); 4.8294 (0.8); 4.3036 (1.7); 4.2818 (1.6); 4.0262 (16.0); 4.0044 (3.7); 3.9911 (6.4); 3.9769 (3.9); 3.3168 (5.8); 3.3028 (8.6); 3.2892 (5.3); 2.8535 (0.7); 2.8276 (1.1); 2.8119 (2.1); 2.7965 (1.3); 2.7881 (1.2); 2.7712 (1.8); 2.7547 (1.3); 2.7287 (0.6); 2.1272 (0.5); 2.1220 (0.5); 2.1127 (0.7); 2.1031 (1.2); 2.0916 (1.3); 2.0808 (1.2); 2.0710 (1.1); 2.0591 (0.9); 1.9709 (0.6); 1.9639 (0.8); 1.9506 (1.4); 1.9442 (1.3); 1.9285 (1.6); 1.9171 (2.0); 1.9115 (1.4); 1.9031 (1.4); 1.8960 (1.8); 1.8854 (0.8); 1.8814 (0.8); 1.8765 (1.1); 1.8684 (1.0); 1.8584 (0.8); 1.8519 (1.1); 1.8444 (1.1); 1.8283 (1.0); 1.8082 (0.7); 1.6273 (2.7); 0.0079 (1.5); 0.0002 (47.6); 0.0085 (1.4)
[0567] I-155: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0568] =8.3146 (0.4); 7.2662 (4.7); 7.2475 (5.1); 7.1282 (2.7); 7.1108 (5.0); 7.0935 (3.0); 6.8470 (3.5); 6.8291 (6.0); 6.8113 (2.8); 6.7674 (0.6); 6.7505 (7.1); 6.7306 (6.3); 6.3341 (0.3); 6.2876 (0.5); 6.2582 (2.8); 6.2362 (2.7); 4.7420 (1.4); 4.7283 (2.9); 4.7165 (2.3); 4.7069 (2.9); 4.6936 (1.5); 4.5500 (0.3); 4.5341 (0.5); 4.2670 (1.2); 4.2586 (1.6); 4.2390 (3.5); 4.2308 (3.0); 4.2195 (2.9); 4.2109 (2.6); 4.1930 (2.5); 4.1838 (3.0); 4.1777 (3.0); 4.1679 (3.1); 4.1564 (1.4); 4.1497 (1.7); 4.1413 (1.2); 4.1118 (0.5); 4.0987 (0.9); 4.0876 (1.2); 4.0767 (1.2); 4.0140 (0.5); 3.9014 (16.0); 3.8506 (4.2); 3.8371 (7.8); 3.8195 (13.7); 3.7784 (0.6); 3.6897 (0.6); 3.6655 (0.3); 3.6423 (0.3); 3.5844 (0.4); 3.4549 (0.4); 3.3232 (70.7); 3.1739 (3.9); 3.1613 (4.0); 3.1469 (3.9); 3.1336 (6.6); 3.1206 (3.7); 3.0504 (0.4); 2.6699 (1.5); 2.5401 (1.2); 2.5051 (216.7); 2.5010 (280.7); 2.4970 (207.0); 2.3279 (1.7); 2.0763 (0.6); 2.0651 (0.9); 2.0554 (1.1); 2.0424 (2.0); 2.0329 (2.6); 2.0217 (3.2); 2.0138 (3.4); 2.0004 (4.0); 1.9917 (3.0); 1.9767 (1.7); 1.9653 (1.1); 1.9571 (0.8); 1.9502 (0.7); 1.9429 (0.4); 1.2355 (0.5); 0.0007 (2.2)
[0569] I-156: .sup.1H-NMR(400.0 MHz, CDCl3):
[0570] =7.2600 (83.9); 7.1988 (3.7); 7.1361 (2.0); 7.1172 (3.1); 7.0495 (2.4); 7.0305 (1.6); 5.2979 (6.0); 5.2159 (0.6); 5.1975 (1.3); 5.1764 (1.4); 5.1578 (0.6); 4.2817 (1.2); 4.2603 (1.1); 4.0348 (11.0); 4.0156 (2.8); 4.0021 (4.9); 3.9880 (3.0); 3.3229 (4.1); 3.3090 (6.0); 3.2954 (3.9); 2.9590 (0.5); 2.9458 (0.5); 2.9371 (0.6); 2.9284 (0.9); 2.9202 (1.0); 2.9076 (0.9); 2.8988 (0.9); 2.8414 (0.6); 2.8212 (1.3); 2.8017 (1.1); 2.7822 (0.7); 2.7626 (0.5); 2.7099 (0.8); 2.7013 (0.7); 2.6921 (0.9); 2.6832 (1.0); 2.6786 (1.0); 2.6726 (0.8); 2.6698 (0.9); 2.6605 (1.0); 2.6519 (1.0); 2.6413 (0.6); 2.6325 (0.6); 2.3263 (16.0); 1.8830 (0.6); 1.8621 (1.5); 1.8517 (0.7); 1.8432 (1.5); 1.8308 (1.4); 1.8218 (0.8); 1.8117 (1.4); 1.7903 (0.6); 1.6231 (3.1); 0.0079 (1.2); 0.0002 (30.2); 0.0084 (1.3)
[0571] I-157: .sup.1H-NMR(400.0 MHz, CDCl3):
[0572] =7.3390 (2.6); 7.3194 (3.0); 7.2603 (85.3); 6.9962 (0.6); 6.9852 (2.2); 6.9602 (1.5); 6.9153 (3.0); 5.2976 (8.9); 4.8384 (0.6); 4.8239 (1.0); 4.8034(1.0); 4.7903 (0.5); 4.2774 (1.3); 4.2569 (1.1); 4.0226 (11.2); 4.0010 (2.6); 3.9877 (4.5); 3.9734 (2.6); 3.3129 (4.1); 3.2990 (6.0); 3.2854 (3.7); 2.8074 (0.6); 2.7810 (0.8); 2.7655 (1.6); 2.7507 (0.9); 2.7430 (0.9); 2.7257 (1.2); 2.7088 (0.9); 2.2935 (16.0); 2.2769 (2.2); 2.2315 (1.1); 2.0863 (0.6); 2.0773 (1.0); 2.0654 (1.0); 2.0543 (0.8); 2.0424 (0.7); 2.0335 (0.6); 1.9505 (0.6); 1.9366 (1.0); 1.9311 (1.1); 1.9237 (0.9); 1.9166 (1.1); 1.9050 (1.1); 1.8975 (1.3); 1.8903 (1.1); 1.8834 (1.1); 1.8780 (0.9); 1.8673 (0.6); 1.8604 (0.6); 1.8554 (0.8); 1.8420 (0.8); 1.8341 (0.8); 1.8270 (0.8); 1.8192 (0.9); 1.8078 (0.8); 1.7998 (0.7); 1.7918 (0.6); 1.7840 (0.6); 1.6404 (5.5); 0.0080 (1.0); 0.0002 (31.1); 0.0084 (0.9)
[0573] 1H-NMR
[0574] I-158: .sup.1H-NMR(400.0 MHz, CDCl3):
[0575] =7.3884 (2.1); 7.3707 (2.5); 7.2619 (66.1); 7.2445 (4.4); 7.2369 (4.1); 7.2202 (2.4); 7.2152 (2.3); 7.2046 (1.7); 7.1894 (0.8); 5.2378 (0.6); 5.2182 (1.6); 5.1993 (1.6); 5.1800 (0.6); 4.7757 (3.8); 4.6449 (7.3); 4.4727 (0.8); 4.4508 (0.8); 4.1122 (1.0); 4.0986 (2.7); 4.0862 (4.1); 4.0736 (3.3); 4.0438 (3.0); 4.0312 (2.6); 4.0189 (1.0); 3.9337 (1.4); 3.9200 (1.9); 3.9073 (1.0); 3.0220 (0.6); 3.0093 (0.6); 3.0004 (0.7); 2.9914 (1.0); 2.9820 (1.2); 2.9691 (1.0); 2.9603 (1.2); 2.9545 (3.8); 2.9040 (0.8); 2.8829 (4.4); 2.8815 (4.2); 2.8633 (1.4); 2.8443 (0.9); 2.8241 (0.6); 2.7149 (0.6); 2.7060 (0.6); 2.6958 (1.0); 2.6838 (1.2); 2.6742 (1.0); 2.6643 (1.2); 2.6551 (1.0); 2.6459 (0.6); 2.6366 (0.5); 2.2305 (7.3); 2.1854 (16.0); 1.8847 (1.1); 1.8662 (1.1); 1.8532 (1.2); 1.8459 (0.9); 1.8342 (1.0); 1.6434 (1.7); 0.0080 (0.8); 0.0002 (25.2); 0.0085 (0.7)
[0576] I-159: .sup.1H-NMR(400.0 MHz, CDCl3):
[0577] =7.4946 (0.8); 7.4909 (0.7); 7.4846 (1.1); 7.4777 (2.2); 7.4737 (3.9); 7.4652 (16.0); 7.4596 (2.9); 7.4556 (2.7); 7.4519 (1.9); 7.3802 (1.1); 7.3626 (1.3); 7.2604 (55.1); 7.2457 (2.5); 7.2425 (3.2); 7.2379 (2.4); 7.2307 (2.8); 7.2277 (2.4); 7.2157 (1.5); 7.2141 (1.6); 7.2084 (1.4); 7.1982 (1.1); 7.1924 (0.8); 7.1829 (0.6); 5.2066 (0.7); 5.1879 (0.7); 4.1209 (1.5); 3.4840 (6.2); 2.9821 (0.7); 2.9730 (0.8); 2.9606 (0.7); 2.9533 (1.7); 2.8944 (0.5); 2.8829 (1.1); 2.8814 (1.1); 2.8742 (1.2); 2.8540 (0.9); 2.8346 (0.6); 2.6854 (0.5); 2.6762 (0.5); 2.6539 (0.6); 2.6449 (0.5); 1.8766 (0.8); 1.8580 (0.8); 1.8449 (0.8); 1.8262 (0.7); 1.6209 (0.6); 0.0079 (0.6); 0.0002 (19.9); 0.0085 (0.7)
[0578] I-160: .sup.1H-NMR(400.0 MHz. CDCl3):
[0579] =8.0165 (0.5); 7.5209 (0.8); 7.3970 (5.6); 7.3799 (6.7); 7.2621 (148.6); 7.2491 (9.2); 7.2457 (12.6); 7.2417 (10.2); 7.2339 (12.9); 7.2307 (10.5); 7.2223 (7.0); 7.2172 (5.6); 7.2123 (5.4); 7.2049 (5.0); 7.1984 (3.4); 7.1892 (2.4); 7.1827 (1.4); 6.9979 (0.8); 5.2453 (1.3); 5.2263 (3.7); 5.2070 (3.7); 5.1885 (1.4); 4.8534 (3.9); 4.4660 (1.5); 4.1081 (7.9); 4.0531 (3.0); 3.4838 (11.5); 3.0299 (1.7); 3.0207 (1.9); 3.0083 (1.9); 2.9989 (2.1); 2.9902(3.4); 2.9810 (3.6); 2.9685 (3.5); 2.9595 (3.7); 2.9546 (6.0); 2.9042 (2.6); 2.8830 (10.0); 2.8817 (8.6); 2.8637 (4.4); 2.8441 (3.0); 2.8238 (1.9); 2.7204 (2.3); 2.7112 (2.2); 2.7024 (2.8); 2.7009 (2.8); 2.6932 (2.9); 2.6888 (3.1); 2.6828 (2.5); 2.6795 (2.8); 2.6736 (2.4); 2.6707 (3.3); 2.6615 (3.1); 2.6511 (2.2); 2.6419 (1.8); 1.9088 (1.9); 1.8877 (4.2); 1.8770 (2.1); 1.8690 (4.2); 1.8560 (4.1); 1.8478 (2.1); 1.8373 (4.0); 1.8160 (1.9); 1.7438 (1.6); 1.6653 (1.8); 1.0818 (2.3); 1.0713 (7.8); 1.0640 (9.2); 1.0533 (8.5); 1.0441 (3.1); 0.9134 (0.5); 0.8957 (4.4); 0.8863 (16.0); 0.8790 (12.0); 0.8665 (15.2); 0.8591 (12.0); 0.8486 (3.5); 0.0080 (1.5); 0.0002 (55.4); 0.0085 (1.6)
[0580] I-161: .sup.1H-NMR(400.0 MHz, CDCl3):
[0581] =7.7741 (1.5); 7.7593 (5.1); 7.7572 (4.8); 7.6732 (1.3); 7.6542 (2.8); 7.6300 (1.6); 7.6103 (1.8); 7.5909 (0.6); 7.3752 (1.3); 7.3576 (1.6); 7.2666 (0.6); 7.2610 (52.2); 7.2568 (0.9); 7.2560 (0.8); 7.2552 (0.7); 7.2544 (0.6); 7.2536 (0.6); 7.2463 (3.1); 7.2432 (4.0); 7.2384 (2.9); 7.2369 (2.8); 7.2315 (3.3); 7.2285 (2.8); 7.2147 (2.2); 7.2092 (1.4); 7.1976 (1.2); 7.1924 (0.9); 7.1825 (0.7); 5.2021 (0.8); 5.1845 (0.8); 4.4170 (0.5); 4.1368 (1.8); 3.4828 (16.0); 3.0129 (0.5); 3.0004 (0.5); 2.9913 (0.6); 2.9826 (0.9); 2.9732 (0.9); 2.9610 (0.9); 2.9519 (0.9); 2.8948 (0.7); 2.8747 (1.4); 2.8546 (1.1); 2.8351 (0.8); 2.6808 (0.6); 2.6705 (0.7); 2.6587 (0.6); 2.6495 (0.7); 2.6397 (0.6); 1.8757 (0.9); 1.8571 (0.9); 1.8440 (0.9); 1.8254 (0.8); 0.0079 (0.6); 0.0002 (20.6); 0.0085 (0.6)
[0582] I-162: .sup.1H-NMR(400.0 MHz, CDCl3):
[0583] =7.5185 (1.1); 7.4622 (1.8); 7.4552 (1.0); 7.4467 (1.8); 7.4399 (16.0); 7.4334 (19.5); 7.4267 (1.6); 7.4182 (1.2); 7.4135 (1.7); 7.4114 (2.0); 7.3781 (2.0); 7.3602 (2.4); 7.2597 (201.4); 7.2487 (4.2); 7.2455 (5.2); 7.2411 (3.7); 7.2394 (3.5); 7.2336 (4.4); 7.2308 (3.4); 7.2171 (2.8); 7.2098 (2.4); 7.2000 (1.6); 7.1943 (1.1); 7.1847 (0.9); 7.1780 (0.6); 6.9956 (1.1); 5.2043 (1.0); 5.1869 (1.1); 4.7637 (0.9); 4.3568 (0.7); 4.1250 (2.9); 3.0254 (0.6); 3.0164 (0.7); 3.0041 (0.7); 2.9948 (0.7); 2.9858 (1.2); 2.9765 (1.3); 2.9645 (1.2); 2.9551 (1.2); 2.8971 (0.9); 2.8770 (2.0); 2.8570 (1.6); 2.8371 (1.1); 2.8172 (0.7); 2.7032 (0.6); 2.6938 (0.6); 2.6838 (0.9); 2.6718 (1.0); 2.6653 (0.8); 2.6620 (0.8); 2.6526 (1.0); 2.6439 (0.9); 2.6339 (0.6); 2.6247 (0.6); 1.8991 (0.7); 1.8780 (1.4); 1.8673 (0.8); 1.8595 (1.4); 1.8463 (1.4); 1.8383 (0.7); 1.8277 (1.3); 1.8065 (0.6); 1.5849 (1.4); 0.0080 (2.2); 0.0002 (76.0); 0.0085 (2.1)
[0584] 1H-NMR
[0585] I-163: .sup.1H-NMR(400.0 MHz, CDCl3):
[0586] =7.4330 (2.0); 7.4178 (2.1); 7.4118 (2.2); 7.2626 (51.4); 7.1722 (2.8); 7.1637 (4.5); 7.1567 (3.5); 7.1491 (2.8); 7.1354 (0.5); 7.1084 (1.9); 7.1025 (2.2); 7.0873 (1.4); 4.8632 (0.6); 4.8461 (1.3); 4.8303 (1.4); 4.8155 (0.7); 4.7641 (3.3); 4.6364 (7.2); 4.4941 (0.9); 4.4721 (1.0); 4.4402 (0.5); 4.0828 (3.5); 4.0796 (3.5); 4.0664 (3.8); 4.0303 (2.8); 4.0172 (2.9); 4.0048 (1.1); 3.9265 (1.3); 3.9125 (1.8); 3.8998 (1.0); 3.4825 (4.8); 2.9541 (1.1); 2.8825 (1.0); 2.8811 (1.0); 2.8551 (0.7); 2.8284 (1.1); 2.8130 (2.2); 2.7961 (1.6); 2.7756 (1.7); 2.7594 (1.1); 2.7332 (0.6); 2.2265 (7.2); 2.1822 (16.0); 2.1162 (0.6); 2.1016 (0.7); 2.0923 (1.3); 2.0812 (1.4); 2.0700 (1.3); 2.0601 (1.2); 2.0486 (0.9); 1.9678 (0.5); 1.9491 (1.2); 1.9427 (1.2); 1.9305 (1.2); 1.9237 (1.3); 1.9160 (1.5); 1.9093 (1.3); 1.8944 (1.5); 1.8750 (1.1); 1.8685 (0.9); 1.8603 (1.0); 1.8529 (1.3); 1.8452 (1.1); 1.8342 (1.0); 1.8104 (0.7); 1.6795 (1.3); 0.0079 (0.5); 0.0002 (19.9); 0.0085 (0.6)
[0587] I-164: .sup.1H-NMR(400.0 MHz, CDCl3):
[0588] =7.4921 (0.8); 7.4887 (0.7); 7.4822 (1.0); 7.4754 (2.1); 7.4715 (3.8); 7.4631 (16.0); 7.4536 (2.4); 7.4497 (1.6); 7.4213 (1.0); 7.4052 (1.0); 7.3997 (1.0); 7.2613 (29.6); 7.1721 (1.3); 7.1673 (1.5); 7.1640 (1.3); 7.1567 (3.8); 7.1496 (2.0); 7.1459 (1.2); 7.1406 (1.3); 7.1022 (1.5); 7.0959 (1.3); 7.0842 (0.7); 7.0801 (0.9); 4.8336 (0.8); 4.8170 (0.8); 4.8023 (0.6); 4.4172 (0.6); 4.3988 (0.5); 4.1069 (1.5); 3.4793 (11.1); 2.8201 (0.6); 2.8052 (1.1); 2.7851 (0.7); 2.7669 (0.9); 2.7506 (0.7); 2.0801 (0.5); 2.0697 (0.6); 2.0582 (0.5); 1.9478 (0.6); 1.9415 (0.6); 1.9336 (0.6); 1.9265 (0.7); 1.9155 (0.7); 1.9077 (0.6); 1.9000 (0.7); 1.8930 (0.6); 1.8860 (0.6); 1.8432 (0.6); 1.8352 (0.6); 1.8234 (0.5); 0.0002 (11.5)
[0589] I-165: .sup.1H-NMR(400.0 MHz, CDCl3):
[0590] =7.2616 (36.9); 7.0879 (3.4); 7.0622 (2.1); 7.0133 (1.9); 6.9975 (1.2); 4.7909 (2.6); 4.7703 (1.7); 4.7483 (0.9); 4.6619 (5.0); 4.3688 (0.7); 4.3444 (1.0); 4.1049 (1.2); 4.0932 (3.0); 4.0802 (3.2); 4.0419 (2.0); 4.0291 (2.1); 4.0162 (0.8); 3.9388 (0.9); 3.9250 (1.2); 3.9124 (0.6); 3.4840 (1.4); 3.0502 (0.7); 3.0312 (0.8); 3.0120 (0.8); 2.9928 (0.9); 2.9544 (0.6); 2.8828 (0.5); 2.5163 (0.9); 2.4934 (1.0); 2.4782 (0.8); 2.4546 (1.0); 2.2965 (16.0); 2.2563 (0.6); 2.2333 (5.9); 2.1940 (11.0); 1.6614 (1.0); 1.2923 (10.2); 1.2755 (10.0); 0.0002 (14.1)
[0591] I-166: .sup.1H-NMR(400.0 MHz, CDCl3):
[0592] =7.5186 (0.6); 7.4955 (1.5); 7.4865 (2.4); 7.4820 (3.4); 7.4724 (16.0); 7.4696 (15.0); 7.4640 (2.2); 7.4598 (2.4); 7.4554 (1.8); 7.4516 (1.3); 7.4369 (0.6); 7.2598 (91.4); 7.2100 (0.5); 7.0857 (3.0); 7.0765 (2.4); 7.0570 (3.5); 7.0102 (2.6); 6.9955 (1.2); 6.9912 (1.5); 4.7824 (1.2); 4.7596 (1.8); 4.7376 (1.0); 4.2816 (0.9); 4.2600 (0.8); 4.1151 (2.1); 3.4857 (3.4); 3.0426 (1.2); 3.0233 (1.3); 3.0041 (1.4); 2.9850 (1.5); 2.5079 (0.9); 2.4855 (1.1); 2.4701 (0.8); 2.4477 (1.0); 2.2947 (15.8); 2.2685 (0.5); 2.2471 (0.9); 2.2291 (1.1); 2.2117 (0.8); 1.5978 (1.2); 1.2850 (9.3); 1.2683 (9.1); 0.0080 (0.9); 0.0002 (35.3); 0.0085 (1.0
[0593] I-167: .sup.1H-NMR(400.0 MHz, CDCl3):
[0594] =7.2605 (75.5); 7.0988 (3.3); 7.0814 (1.8); 7.0623 (3.0); 7.0142 (2.3); 6.9965 (1.6); 4.8880 (1.0); 4.8022 (1.0); 4.7794 (1.7); 4.7580 (1.0); 4.3182 (0.8); 4.2955 (0.8); 4.1223 (2.3); 4.0595 (0.8); 3.4869 (1.2); 3.0503 (1.0); 3.0311 (1.1); 3.0117 (1.2); 2.9927 (1.2); 2.5182 (0.9); 2.4954 (1.0); 2.4805 (0.8); 2.4569 (1.0); 2.2993 (16.0); 2.2802 (0.5); 2.2601 (0.8); 2.2409 (1.0); 2.2234 (0.7); 1.6281 (1.2); 1.2976 (13.6); 1.2808 (13.3); 1.0889 (0.7); 1.0784 (2.4); 1.0711 (2.7); 1.0678 (2.6); 1.0602 (2.5); 1.0510 (1.0); 0.8997 (1.1); 0.8905 (4.1); 0.8831 (3.2); 0.8707 (3.9); 0.8632 (3.2); 0.8528 (0.9); 0.0080 (0.8); 0.0002 (29.0); 0.0085 (0.9)
[0595] I-168: .sup.1H-NMR(400.0 MHz, CDCl3):
[0596] =7.7731 (3.9); 7.7713 (4.2); 7.7691 (4.3); 7.7627 (2.6); 7.7572 (2.3); 7.6825 (1.6); 7.6633 (3.2); 7.6323 (1.9); 7.6236 (0.5); 7.6126 (2.3); 7.5927 (0.8); 7.2603 (63.8); 7.0770 (5.1); 7.0577 (3.7); 7.0115 (2.8); 6.9922 (1.5); 4.7765 (1.1); 4.7552 (1.7); 4.7337 (1.1); 4.3159 (0.8); 4.2947 (0.8); 4.1347 (2.0); 3.4835 (7.0); 3.0428 (1.2); 3.0237 (1.3); 3.0044 (1.4); 2.9853 (1.5); 2.5083 (1.0); 2.4856 (1.1); 2.4700 (0.8); 2.4474 (1.1); 2.2929 (16.0); 2.2688 (0.5); 2.2489 (0.9); 2.2297 (1.1); 2.2113 (0.8); 1.6263 (0.6); 1.2963 (0.6); 1.2825 (9.1); 1.2658 (8.8); 0.0080 (0.6); 0.0002 (24.6); 0.0085 (0.7)
[0597] 1H-NMR
[0598] I-169: .sup.1H-NMR(400.0 MHz, CDCl3):
[0599] =7.4791 (0.8); 7.4745 (1.1); 7.4623 (1.1); 7.4593 (1.3); 7.4566 (1.7); 7.4385 (0.8); 7.4334 (0.8); 7.4204 (1.9); 7.4163 (2.0); 7.4101 (2.0); 7.4024 (1.8); 7.3981 (1.5); 7.3925 (2.4); 7.3859 (3.1); 7.3805 (2.1); 7.3747 (1.4); 7.3667 (3.3); 7.3634 (2.4); 7.3579 (2.9); 7.3421 (2.4); 7.2681 (0.5); 7.2673 (0.6); 7.2664 (0.8); 7.2656 (1.0); 7.2608 (66.2); 7.2551 (1.0); 7.2527 (0.6); 7.1043 (2.0); 7.0813 (1.3); 7.0633 (4.2); 7.0531 (2.6); 7.0096 (2.3); 6.9967 (1.4); 6.9903 (1.2); 5.0444 (0.8); 5.0310 (0.8); 4.9552 (0.9); 4.9472 (0.8); 4.7792 (1.0); 4.7649 (0.8); 4.7576 (0.8); 4.7434 (1.2); 4.7222 (0.7); 4.5226 (1.2); 4.4283 (1.2); 4.3828 (0.7); 4.3508 (0.9); 4.3275 (1.0); 4.2769 (1.1); 4.2546 (1.1); 4.1862 (1.1); 4.1744 (1.9); 4.1603 (1.4); 4.1442 (0.9); 4.0993 (0.6); 3.9714 (0.5); 3.9567 (0.5); 3.7579 (0.7); 3.7172 (0.8); 3.4815 (16.0); 3.0511 (0.7); 3.0384 (0.9); 3.0327 (0.8); 3.0191 (1.0); 3.0129 (0.9); 2.9997 (1.1); 2.9940 (1.0); 2.9810 (1.0); 2.9539 (1.4); 2.8826 (1.2); 2.8812 (1.2); 2.5191 (0.5); 2.4983 (1.2); 2.4784 (1.1); 2.4599 (1.1); 2.4391 (0.7); 2.3051 (8.8); 2.2897 (11.7); 2.2614 (0.9); 2.2417 (1.2); 2.2239 (1.2); 2.2046 (0.9); 1.6398 (0.6); 1.3010 (6.0); 1.2842 (6.4); 1.2728 (9.1); 1.2659 (1.6); 1.2560 (8.7); 0.0080 (0.7); 0.0002 (26.2); 0.0085 (0.9)
[0600] I-170: .sup.1H-NMR(400.0 MHz, CDCl3):
[0601] =7.4888 (0.6); 7.4835 (2.6); 7.4809 (5.8); 7.4770 (5.4); 7.4720 (4.3); 7.4676 (3.0); 7.4642 (3.3); 7.4590 (1.5); 7.4250 (2.1); 7.4171 (0.5); 7.4061 (3.5); 7.3979 (0.9); 7.3849 (2.2); 7.3631 (3.0); 7.3595 (5.3); 7.3558 (2.8); 7.3442 (1.6); 7.3406 (2.7); 7.3370 (1.3); 7.2607 (57.2); 7.0787 (4.2); 7.0581 (3.6); 7.0132 (2.6); 7.0115 (2.7); 6.9926 (1.5); 4.7792 (1.1); 4.7574 (1.8); 4.7355 (1.2); 4.3223 (0.8); 4.3003 (0.8); 4.1149 (2.1); 3.4831 (10.5); 3.0435 (1.2); 3.0244 (1.3); 3.0050 (1.4); 2.9858 (1.5); 2.9540 (1.0); 2.8828 (0.9); 2.8814 (0.9); 2.5088 (0.9); 2.4864 (1.1); 2.4709 (0.8); 2.4483 (1.0); 2.2948 (16.0); 2.2695 (0.6); 2.2487 (0.9); 2.2303 (1.2); 2.2126 (0.8); 1.6356 (0.5); 1.2842 (9.7); 1.2674 (9.4); 0.0079 (0.6); 0.0002 (21.9); 0.0085 (0.7)
[0602] I-171: .sup.1H-NMR(400.0 MHz, CDCl3):
[0603] =7.4642 (0.8); 7.4616 (0.7); 7.4562 (0.5); 7.4491 (0.9); 7.4413 (16.0); 7.4384 (18.5); 7.4308 (0.8); 7.4238 (0.6); 7.4184 (0.8); 7.4158 (0.9); 7.2609 (46.1); 7.0775 (4.3); 7.0574 (3.0); 7.0127 (2.2); 7.0109 (2.3); 6.9938 (1.2); 6.9919 (1.2); 4.7767 (1.2); 4.7552 (1.8); 4.7336 (1.0); 4.3243 (0.8); 4.3019 (0.8); 4.1100 (2.2); 3.4822 (9.7); 3.0422 (1.0); 3.0231 (1.1); 3.0037 (1.2); 2.9846 (1.3); 2.9542 (0.8); 2.8828 (0.7); 2.8813 (0.7); 2.5084 (0.8); 2.4855 (1.0); 2.4697 (0.7); 2.4478 (0.9); 2.2932 (13.8); 2.2472 (0.8); 2.2280 (1.0); 2.2107 (0.7); 1.2823 (9.2); 1.2655 (9.0); 0.0002 (18.4); 0.0085 (0.5)
[0604] I-172: .sup.1H-NMR(400.0 MHz, CDCl3):
[0605] =7.5191 (0.6); 7.2603 (103.5); 7.2106 (0.5); 7.0938 (3.4); 7.0822 (1.7); 7.0631 (2.7); 7.0150 (2.2); 6.9962 (1.8); 4.7965 (1.1); 4.7754 (2.1); 4.7528 (1.4); 4.7261 (1.5); 4.2806 (1.2); 4.2563 (1.1); 4.0870 (1.4); 4.0343 (1.2); 3.4887 (2.4); 3.0508 (0.8); 3.0319 (0.9); 3.0123 (1.0); 2.9934 (1.0); 2.5167 (1.3); 2.4942 (1.4); 2.4789 (1.0); 2.4558 (1.0); 2.2973 (16.0); 2.2586 (0.7); 2.2396 (0.9); 2.2222 (0.6); 1.8224 (1.3); 1.7770 (1.2); 1.7444 (1.7); 1.5920 (1.9); 1.2955 (13.4); 1.2787 (13.8); 0.0079 (1.1); 0.0002 (38.8); 0.0085 (1.1)
[0606] I-173: .sup.1H-NMR(400.0 MHz, CDCl3):
[0607] =7.2625 (38.9); 7.1882 (3.5); 7.1420 (1.4); 7.1230 (2.2); 7.0562 (2.0); 7.0374 (1.3); 5.1779 (1.3); 5.1587 (1.3); 4.7786 (2.7); 4.6478 (5.5); 4.4566 (0.7); 4.4344 (0.7); 4.4174 (0.5); 4.1142 (0.7); 4.1002 (2.1); 4.0876 (3.2); 4.0749 (2.6); 4.0456 (2.3); 4.0332 (2.0); 3.9352 (1.0); 3.9215 (1.5); 3.9085 (0.8); 3.4840 (3.6); 2.9546 (1.5); 2.9369 (0.7); 2.9281 (0.8); 2.9072 (0.8); 2.8828 (1.0); 2.8815 (1.0); 2.8486 (0.5); 2.8287 (1.2); 2.8085 (0.9); 2.7895 (0.6); 2.6824 (0.7); 2.6706 (0.9); 2.6612 (0.8); 2.6511 (0.9); 2.6420 (0.8); 2.3289 (16.0); 2.2315 (5.6); 2.1863 (11.9); 1.8660 (0.8); 1.8472 (0.9); 1.8349 (0.9); 1.8273 (0.7); 1.8156 (0.7); 1.6689 (1.0); 0.0002 (14.2); 0.0085 (0.5)
[0608] I-174: .sup.1H-NMR(400.0 MHz, CDCl3):
[0609] =7.4941 (0.8); 7.4907 (0.7); 7.4842 (1.1); 7.4774 (2.2); 7.4735 (3.8); 7.4651 (16.0); 7.4557 (2.4); 7.4516 (1.6); 7.2606 (34.2); 7.1795 (2.2); 7.1360 (1.5); 7.1169 (2.4); 7.0541 (1.7); 7.0523 (1.8); 7.0332 (1.1); 5.1662 (0.7); 5.1475 (0.7); 4.3725 (0.5); 4.3530 (0.5); 4.1199 (1.5); 3.4806 (7.4); 2.9276 (0.6); 2.9187 (0.6); 2.9059 (0.6); 2.8974 (0.6); 2.8199 (0.9); 2.8000 (0.7); 2.7808 (0.5); 2.6721 (0.5); 2.6626 (0.5); 2.6593 (0.5); 2.6406 (0.6); 2.6317 (0.5); 2.3248 (11.5); 1.8578 (0.8); 1.8389 (0.8); 1.8263 (0.8); 1.8074 (0.7); 0.0002 (13.1)
[0610] 1H-NMR
[0611] I-175: .sup.1H-NMR(400.0 MHz, CDCl3):
[0612] =7.2615 (43.3); 7.1956 (3.3); 7.1412 (1.9); 7.1221 (2.9); 7.0560 (2.2); 7.0370 (1.4); 5.1867 (1.0); 5.1680 (1.0); 4.8635 (1.1); 4.4088 (0.5); 4.1123 (2.3); 4.0598 (0.8); 3.4846 (4.7); 2.9544 (3.0); 2.9458 (0.5); 2.9371 (0.8); 2.9282 (0.8); 2.9154 (0.8); 2.9068 (0.8); 2.8831 (2.2); 2.8817 (2.2); 2.8503 (0.6); 2.8301 (1.2); 2.8102 (1.0); 2.7912 (0.7); 2.7072 (0.7); 2.6984 (0.6); 2.6894 (0.8); 2.6805 (0.8); 2.6758 (0.9); 2.6699 (0.7); 2.6668 (0.8); 2.6609 (0.7); 2.6577 (0.9); 2.6488 (0.9); 2.6385 (0.6); 2.6294 (0.5); 2.3306 (16.0); 1.8914 (0.5); 1.8704 (1.2); 1.8599 (0.6); 1.8516 (1.2); 1.8390 (1.1); 1.8304 (0.6); 1.8201 (1.2); 1.7988 (0.6); 1.0830 (0.7); 1.0724 (2.2); 1.0651 (2.7); 1.0545 (2.4); 1.0452 (0.9); 0.8963 (1.2); 0.8869 (4.5); 0.8796 (3.4); 0.8671 (4.2); 0.8597 (3.4); 0.8492 (1.0); 0.0002 (16.5)
[0613] I-176: .sup.1H-NMR(400.0 MHz, CDCl3):
[0614] =7.7740 (1.8); 7.7671 (2.0); 7.7606 (5.0); 7.7585 (5.1); 7.7568 (4.7); 7.6749 (1.5); 7.6560 (3.2); 7.6304 (1.8); 7.6107 (2.1); 7.5907 (0.7); 7.2607 (55.7); 7.1745 (3.0); 7.1377 (2.1); 7.1186 (3.3); 7.0546 (2.5); 7.0355 (1.6); 5.1618 (0.9); 5.1438 (1.0); 4.3728 (0.7); 4.3574 (0.7); 4.1417 (2.0); 3.4834 (10.6); 2.9594 (0.5); 2.9543 (1.6); 2.9477 (0.5); 2.9379 (0.5); 2.9295 (0.8); 2.9204 (0.9); 2.9080 (0.9); 2.8993 (0.8); 2.8827 (1.2); 2.8813 (1.2); 2.8407 (0.6); 2.8210 (1.3); 2.8011 (1.0); 2.7817 (0.7); 2.6685 (0.7); 2.6589 (0.8); 2.6465 (0.6); 2.6374 (0.8); 2.6282 (0.7); 2.3247 (16.0); 1.8585 (1.1); 1.8477 (0.5); 1.8397 (1.1); 1.8270 (1.0); 1.8188 (0.5); 1.8082 (1.0); 0.0079 (0.6); 0.0002 (22.0); 0.0085 (0.6)
[0615] I-177: .sup.1H-NMR(400.0 MHz, CDCl3):
[0616] =7.4785 (0.7); 7.4740 (1.0); 7.4616 (1.0); 7.4588 (1.2); 7.4558 (1.6); 7.4424 (0.8); 7.4377 (0.9); 7.4337 (0.8); 7.4281 (0.9); 7.4240 (1.4); 7.4189 (2.0); 7.4164 (2.1); 7.4105 (1.8); 7.4028 (2.0); 7.3978 (1.4); 7.3916 (2.8); 7.3858 (2.6); 7.3802 (1.8); 7.3733 (1.5); 7.3666 (2.3); 7.3602 (2.1); 7.3552 (2.4); 7.3525 (2.3); 7.3375 (2.8); 7.3198 (0.5); 7.2612 (55.7); 7.1977 (1.8); 7.1667 (1.8); 7.1430 (1.0); 7.1329 (1.4); 7.1238 (1.7); 7.1139 (2.1); 7.0518 (1.7); 7.0328 (1.0); 5.1863 (0.6); 5.1682 (0.8); 5.1518 (0.9); 5.1337 (0.8); 5.0280 (0.7); 5.0142 (0.8); 4.9594 (0.8); 4.9474 (0.7); 4.5154 (1.2); 4.4233 (1.4); 4.3814 (0.9); 4.3371 (1.0); 4.3206 (0.8); 4.2421 (0.5); 4.1909 (1.0); 4.1798 (1.7); 4.1660 (1.3); 4.1516 (0.7); 4.1101 (0.5); 3.7695 (0.6); 3.7532 (0.6); 3.7272 (0.5); 3.7144 (0.7); 3.4815 (16.0); 2.9540 (1.4); 2.9408 (0.7); 2.9315 (0.8); 2.9157 (0.9); 2.9032 (0.6); 2.8938 (0.5); 2.8825 (0.8); 2.8811 (0.8); 2.8319 (0.9); 2.8128 (1.2); 2.7935 (0.9); 2.7742 (0.6); 2.6772 (0.7); 2.6683 (0.7); 2.6589 (0.9); 2.6498 (0.9); 2.6399 (0.7); 2.6305 (0.6); 2.3353 (7.9); 2.3199 (10.0); 1.8759 (0.8); 1.8565 (1.0); 1.8445 (0.8); 1.8358 (0.8); 1.8250 (1.0); 1.8042 (0.7); 1.6460 (0.5); 0.0079 (0.6); 0.0002 (21.2); 0.0085 (0.7)
[0617] I-178: .sup.1H-NMR(400.0 MHz, CDCl3):
[0618] =7.4875 (0.8); 7.4823 (1.8); 7.4791 (1.9); 7.4743 (3.4); 7.4692 (6.0); 7.4656 (7.2); 7.4630 (4.1); 7.4577 (1.1); 7.4228 (1.8); 7.4095 (0.6); 7.4039 (3.0); 7.3904 (0.7); 7.3825 (1.9); 7.3554 (2.8); 7.3519 (4.6); 7.3483 (2.7); 7.3365 (1.6); 7.3329 (2.6); 7.3294 (1.4); 7.2605 (50.9); 7.1781 (3.2); 7.1380 (2.1); 7.1190 (3.3); 7.0546 (2.5); 7.0355 (1.6); 5.1644 (1.0); 5.1464 (1.0); 4.7581 (0.5); 4.3738 (0.7); 4.3567 (0.7); 4.1229 (2.2); 3.4836 (9.8); 2.9604 (0.5); 2.9476 (0.5); 2.9388 (0.6); 2.9304 (0.8); 2.9213 (0.9); 2.9089 (0.9); 2.8999 (0.9); 2.8421 (0.6); 2.8218 (1.3); 2.8018 (1.0); 2.7826 (0.7); 2.6708 (0.7); 2.6618 (0.8); 2.6489 (0.7); 2.6395 (0.9); 2.6302 (0.7); 2.3260 (16.0); 1.8597 (1.1); 1.8490 (0.6); 1.8410 (1.2); 1.8282 (1.1); 1.8200 (0.6); 1.8095 (1.0); 0.0080 (0.6); 0.0002 (18.7); 0.0085 (0.6)
[0619] I-179: .sup.1H-NMR(400.0 MHz, CDCl3):
[0620] =7.4606 (1.2); 7.4537 (0.7); 7.4451 (1.2); 7.4383 (10.7); 7.4316 (12.7); 7.4249 (1.1); 7.4163 (0.8); 7.4116 (1.1); 7.4095 (1.4); 7.2607 (35.2); 7.1755 (2.7); 7.1371 (1.8); 7.1180 (2.7); 7.0537 (2.0); 7.0347 (1.3); 5.1528 (0.7); 4.7598 (0.6); 4.1180 (2.1); 3.4823 (16.0); 2.9286 (0.7); 2.9196 (0.7); 2.9072 (0.7); 2.8984 (0.7); 2.8210 (1.1); 2.8011 (0.8); 2.7818 (0.6); 2.6699 (0.6); 2.6609 (0.6); 2.6570 (0.6); 2.6509 (0.5); 2.6477 (0.6); 2.6384 (0.7); 2.6294 (0.6); 2.3247 (13.4); 2.0028 (0.6); 1.8562 (1.0); 1.8374 (1.0); 1.8247 (0.9); 1.8059 (0.9); 0.0002 (13.0)
[0621] 1H-NMR
[0622] I-180: .sup.1H-NMR(400.0 MHz, CDCl3):
[0623] =7.2623 (36.5); 7.2402 (3.8); 6.9930 (6.8); 4.8018 (0.9); 4.7867 (1.2); 4.7731 (3.1); 4.6490 (5.0); 4.4492 (0.7); 4.4273 (1.0); 4.0810 (2.5); 4.0708 (2.5); 4.0381 (2.1); 4.0256 (2.0); 3.9300 (0.9); 3.9164 (1.3); 3.9033 (0.7); 3.4833 (5.1); 2.9545 (2.0); 2.8827 (1.8); 2.8814 (1.7); 2.7797 (0.8); 2.7645 (1.5); 2.7486 (0.9); 2.7252 (1.2); 2.7090 (0.8); 2.2794 (16.0); 2.2289 (5.1); 2.1855 (11.1); 2.0836 (0.6); 2.0745 (1.0); 2.0629 (1.0); 2.0518 (0.9); 2.0425 (0.8); 2.0308 (0.7); 1.9370 (0.6); 1.9284 (0.8); 1.9220 (0.9); 1.9155 (0.9); 1.9036 (1.0); 1.8946 (1.0); 1.8885 (1.0); 1.8810 (0.9); 1.8749 (1.0); 1.8643 (0.6); 1.8530 (0.8); 1.8452 (0.7); 1.8384 (0.6); 1.8304 (0.8); 1.8215 (0.8); 1.8097 (0.8); 1.7871 (0.5); 1.6780 (0.7); 0.0002 (14.1)
[0624] I-181: .sup.1H-NMR(400.0 MHz, CDCl3):
[0625] =7.4922 (0.9); 7.4894 (0.7); 7.4822 (1.1); 7.4723 (3.6); 7.4638 (16.0); 7.4546 (2.3); 7.4501 (1.6); 7.2605 (31.9); 7.2296 (2.4); 6.9962 (0.5); 6.9893 (9.0); 6.9866 (8.3); 4.7747 (1.1); 4.3811 (0.6); 4.3623 (0.6); 4.1148 (1.6); 3.4807 (5.4); 2.9534 (0.6); 2.7726 (0.6); 2.7575 (1.1); 2.7423 (0.7); 2.7350 (0.6); 2.7180 (0.9); 2.7010 (0.7); 2.2739 (12.7); 2.0634 (0.5); 2.0529 (0.6); 2.0410 (0.5); 1.9297 (0.6); 1.9237 (0.6); 1.9156 (0.6); 1.9086 (0.7); 1.8975 (0.8); 1.8825 (0.7); 1.8645 (0.6); 1.8203 (0.6); 1.8121 (0.6); 1.8004 (0.6); 0.0002 (12.1)
[0626] I-182: .sup.1H-NMR(400.0 MHz, CDCl3):
[0627] =7.2610 (47.0); 7.2490 (3.5); 6.9955 (9.4); 6.9929 (8.8); 4.8758 (0.9); 4.8285 (0.8); 4.8151 (1.2); 4.7956 (1.2); 4.7813 (0.6); 4.3985 (0.7); 4.3782 (0.7); 4.1110 (2.1); 4.0551 (0.8); 3.4861 (3.8); 2.9551 (0.6); 2.7832 (0.7); 2.7679 (1.4); 2.7526 (0.8); 2.7448 (0.7); 2.7276 (1.0); 2.7108 (0.8); 2.2818 (16.0); 2.0817 (0.8); 2.0702 (0.8); 2.0588 (0.7); 2.0499 (0.7); 2.0379 (0.5); 1.9417 (0.7); 1.9351 (0.7); 1.9269 (0.7); 1.9200 (0.8); 1.9088 (0.8); 1.8997 (0.8); 1.8932 (0.8); 1.8862 (0.7); 1.8798 (0.7); 1.8693 (0.5); 1.8577 (0.6); 1.8489 (0.6); 1.8401 (0.5); 1.8333 (0.7); 1.8255 (0.8); 1.8137 (0.7); 1.7980 (0.6); 1.7901 (0.7); 1.7773 (0.6); 1.7638 (0.5); 1.7560 (0.5); 1.6323 (1.0); 1.0822 (0.6); 1.0717 (2.2); 1.0644 (2.5); 1.0537 (2.4); 1.0445 (0.9); 0.8947 (1.2); 0.8855 (3.8); 0.8781 (3.0); 0.8656 (3.7); 0.8582 (3.0); 0.8478 (0.9); 0.0002 (18.1); 0.0085 (0.6)
[0628] I-183: .sup.1H-NMR(400.0 MHz, CDCl3):
[0629] =7.7722 (1.7); 7.7590 (4.6); 7.7569 (4.7); 7.6738 (1.4); 7.6545 (3.0); 7.6289 (1.8); 7.6090 (2.0); 7.5893 (0.7); 7.2604 (49.2); 7.2207 (3.0); 7.2110 (0.6); 6.9911 (11.2); 6.9884 (10.7); 4.7730 (1.3); 4.3862 (0.7); 4.3673 (0.7); 4.1354 (2.0); 3.4831 (9.1); 2.9542 (0.7); 2.8827 (0.6); 2.8813 (0.6); 2.7734 (0.8); 2.7581 (1.4); 2.7430 (0.9); 2.7362 (0.8); 2.7192 (1.2); 2.7017 (0.8); 2.2737 (16.0); 2.0597 (0.7); 2.0502 (0.8); 2.0380 (0.6); 2.0272 (0.6); 1.9282 (0.8); 1.9223 (0.8); 1.9137 (0.8); 1.9070 (0.9); 1.8959 (0.9); 1.8810 (0.9); 1.8649 (0.7); 1.8428 (0.6); 1.8354 (0.6); 1.8273 (0.6); 1.8203 (0.8); 1.8122 (0.8); 1.8009 (0.7); 1.7853 (0.5); 0.0080 (0.5); 0.0002 (19.2); 0.0085 (0.5)
[0630] I-184: .sup.1H-NMR(400.0 MHz, CDCl3):
[0631] =7.4773 (0.7); 7.4728 (1.1); 7.4603 (1.0); 7.4576 (1.3); 7.4546 (1.7); 7.4416 (0.9); 7.4371 (1.2); 7.4323 (0.7); 7.4268 (1.0); 7.4235 (1.7); 7.4209 (2.0); 7.4187 (2.3); 7.4149 (1.8); 7.4091 (1.7); 7.4012 (2.0); 7.3965 (1.4); 7.3901 (2.9); 7.3840 (2.9); 7.3789 (1.8); 7.3718 (1.6); 7.3651 (2.2); 7.3574 (2.1); 7.3532 (2.9); 7.3499 (2.8); 7.3367 (3.5); 7.3326 (2.7); 7.3191 (0.7); 7.2608 (57.9); 7.2507 (2.0); 7.2212 (1.7); 6.9965 (5.9); 6.9939 (5.8); 6.9867 (7.5); 6.9841 (7.0); 5.0124 (1.1); 4.9507 (1.1); 4.8139 (0.5); 4.7942 (0.9); 4.7799 (0.9); 4.7607 (0.7); 4.5547 (0.5); 4.5119 (1.4); 4.4235 (2.0); 4.4045 (0.8); 4.3807 (1.0); 4.3530 (1.3); 4.3341 (1.0); 4.2159 (0.5); 4.2050 (0.5); 4.1717 (2.2); 4.1583 (1.3); 4.1430 (0.7); 4.1188 (0.5); 4.1051 (0.6); 3.7647 (0.6); 3.7485 (0.6); 3.7218 (0.5); 3.7086 (0.8); 3.4817 (16.0); 2.7687 (1.2); 2.7527 (1.4); 2.7292 (1.2); 2.7117 (1.2); 2.6960 (0.7); 2.2862 (9.0); 2.2698 (10.0); 2.0840 (0.6); 2.0751 (0.7); 2.0631 (0.7); 2.0515 (0.9); 2.0401 (0.8); 2.0286 (0.6); 2.0165 (0.5); 1.9438 (0.7); 1.9373 (0.8); 1.9232 (1.1); 1.9168 (0.9); 1.9097 (1.0); 1.9038 (1.1); 1.8970 (0.9); 1.8903 (1.2); 1.8850 (1.0); 1.8759 (0.9); 1.8695 (0.9); 1.8553 (0.7); 1.8351 (0.8); 1.8279 (0.9); 1.8198 (0.8); 1.8129 (1.0); 1.8057 (0.9); 1.7932 (0.8); 1.7786 (0.6); 1.6370 (0.6); 0.0080 (0.6); 0.0002 (22.5); 0.0085 (0.6)
[0632] 1H-NMR
[0633] I-185: .sup.1H-NMR(400.0 MHz, CDCl3):
[0634] =7.4859 (0.6); 7.4808 (1.4); 7.4775 (1.4); 7.4729 (2.5); 7.4678 (4.4); 7.4641 (5.4); 7.4614 (2.9); 7.4562 (0.7); 7.4216 (1.4); 7.4027 (2.2); 7.3893 (0.5); 7.3814(1.4); 7.3545 (2.0); 7.3510 (3.4); 7.3474 (2.0); 7.3357 (1.2); 7.3321(2.0); 7.3286 (1.0); 7.2610 (35.1); 7.2255 (2.5); 6.9914 (8.7); 6.9888(8.6); 4.7742 (1.1); 4.3911 (0.6); 4.3726 (0.6); 4.1165 (1.7); 3.4830 (16.0); 2.7741 (0.6); 2.7591 (1.2); 2.7438 (0.7); 2.7366 (0.7); 2.7191(0.9); 2.7023 (0.6); 2.2752 (12.9); 2.0614 (0.6); 2.0514 (0.6); 2.0395(0.5); 1.9303 (0.6); 1.9242 (0.6); 1.9166 (0.6); 1.9095 (0.7); 1.8982 (0.8); 1.8828 (0.7); 1.8645 (0.6); 1.8442 (0.5); 1.8214 (0.6); 1.8134 (0.6): 1.8015 (0.6); 0.0002 (13.7)
[0635] I-186: .sup.1H-NMR(400.0 MHz, CDCl3):
[0636] =7.4597 (1.3); 7.4528 (0.7); 7.4442 (1.4); 7.4374 (12.2); 7.4310 (14.4); 7.4242 (1.2); 7.4156 (0.9); 7.4109 (1.3); 7.4087 (1.5); 7.2611 (42.3); 7.2229 (3.1); 6.9908 (10.8); 6.9880 (10.1); 4.8033 (0.6); 4.7708 (1.4); 4.7575 (1.1); 4.3899 (0.8); 4.3697 (0.8); 4.1136 (2.3); 3.4826 (16.0); 2.7734 (0.7); 2.7584 (1.4); 2.7431 (0.8); 2.7362(0.8); 2.7198 (1.1); 2.7023 (0.8); 2.2743(15.7); 2.0608(0.7); 2.0500(0.8); 2.0390 (0.6); 2.0289 (0.6); 1.9278 (0.8); 1.9211 (0.7); 1.9132 (0.8); 1.9065 (0.8); 1.8954 (0.9); 1.8862 (0.7); 1.8796 (0.9); 1.8728 (0.8); 1.8649 (0.7); 1.8544 (0.5); 1.8436 (0.6); 1.8355 (0.6); 1.8281 (0.6); 1.8207 (0.8); 1.8124 (0.8); 1.8012 (0.7); 1.7857 (0.5); 0.0002 (16.4)
[0637] I-187: .sup.1H-NMR(400.0 MHz, CDCl3):
[0638] =7.2618 (45.9); 7.2440 (3.5); 6.9952 (8.4); 6.9930 (7.9); 4.8082 (0.9); 4.7891 (1.1); 4.7746 (0.8); 4.7081 (1.4); 4.3868 (1.0); 4.3660 (1.0); 4.0758 (1.4); 4.0251 (1.2); 3.4849 (11.8); 2.7817 (0.7); 2.7668 (1.4); 2.7521 (0.8); 2.7432(0.7); 2.7265 (1.0); 2.7092 (0.8); 2.2801 (16.0); 2.0771 (0.8); 2.0655 (0.9); 2.0541 (0.8); 2.0452 (0.7); 2.0419 (0.7); 2.0334 (0.6); 1.9239 (0.7); 1.9099 (0.8); 1.8967 (0.9); 1.8903 (0.8); 1.8833 (0.7); 1.8767 (0.9); 1.8544 (1.2); 1.8462 (1.4); 1.8308 (1.9); 1.8228 (2.0); 1.8159 (1.8); 1.8121 (1.8); 1.7879 (0.9); 1.7690 (1.4); 1.7286 (1.9); 1.5494 (0.8); 1.2791 (2.0); 0.0002 (18.3); 0.0085 (0.6)
[0639] I-188: .sup.1H-NMR(400.0 MHz, CDCl3):
[0640] =7.5198 (0.7); 7.2609 (116.2); 7.2412 (2.4); 7.2111 (0.6); 7.0846 (1.1); 6.9969 (0.8); 6.9876 (0.6); 6.9629 (1.1); 6.9417 (1.3); 6.7694 (0.8); 6.7485 (0.7); 6.7201 (1.9); 6.6995 (1.6); 5.0117 (0.7); 4.9962 (0.7); 4.7867 (1.6); 4.6764 (0.6); 4.6499 (3.9); 4.6399 (1.9); 4.3058 (1.0); 4.3019 (1.1); 4.2900 (1.0); 4.2862 (1.0); 4.2775 (1.0); 4.2736 (1.0); 4.2618 (1.0); 4.2579 (0.9); 4.0950 (1.9); 4.0862 (2.8); 4.0746 (2.3); 4.0367 (2.0); 4.0245 (1.8); 3.9387 (0.9); 3.9250 (1.2); 3.4887 (5.2); 2.9549 (2.1); 2.8838 (1.8); 2.8824 (1.8); 2.5285 (0.6); 2.5119 (0.6); 2.4959 (0.7); 2.2833 (0.5); 2.2461 (7.8); 2.2403 (16.0); 2.2156 (0.8); 2.1927 (8.7); 2.1847 (4.3); 1.6331 (0.9); 1.6048 (2.3); 1.6005 (2.0); 1.5898 (2.1); 1.5767 (1.7); 1.5725 (2.1); 1.5439 (0.8); 1.4168 (3.5); 1.4007 (13.1); 1.3849 (9.8); 0.0080 (1.2); 0.0002 (45.2); 0.0085 (1.3)
[0641] I-189: .sup.1H-NMR(400.0 MHz, CDCl3):
[0642] =7.5188 (0.8); 7.4994 (1.0); 7.4894 (1.2); 7.4819 (2.2); 7.4781 (3.8); 7.4693 (16.0); 7.4658 (10.1); 7.4599 (3.0); 7.4559 (2.6); 7.2600 (112.8); 7.2335 (1.7); 7.2100 (0.6); 7.0740 (0.8); 7.0067 (0.6); 7.0014 (0.5); 6.9959 (0.7); 6.9862 (0.7); 6.9806 (0.6); 6.9618 (1.0); 6.9565 (1.0); 6.9412 (1.2); 6.9358 (1.2); 6.7632 (1.4); 6.7424 (1.2); 6.7144 (3.1); 6.6937 (2.6); 4.7849 (0.6); 4.6650 (0.5); 4.2912 (0.7); 4.2761 (1.2); 4.2673 (1.0); 4.2514 (1.1); 4.2324 (0.6); 4.2124 (0.5); 4.2033 (0.5); 4.1159 (1.9); 3.4879 (2.0); 2.5301 (0.6); 2.5186 (0.6); 2.5151 (0.6); 2.5011 (0.7); 2.4861 (0.7); 2.2362 (12.7); 1.6232 (0.6); 1.5946 (1.4); 1.5622 (1.4); 1.5341 (0.6); 1.4101 (3.6); 1.3939 (10.5); 1.3780 (7.3); 0.0080 (1.2); 0.0002 (42.4); 0.0085 (1.3)
[0643] I-190: .sup.1H-NMR(400.0 MHz, CDCl3):
[0644] =7.2607 (18.0); 7.0829 (2.1); 7.0621 (1.3); 7.0172 (1.0); 7.0154 (1.0); 6.9966 (0.6); 4.7646 (0.7); 4.5052 (4.4); 4.1557 (0.9); 4.1426 (1.7); 4.1282 (1.2); 3.8162 (1.5); 3.8015 (1.8); 3.7888 (1.1); 3.4850 (1.1); 3.0310 (0.5); 3.0116 (0.6); 2.9925 (0.6); 2.9539 (1.2); 2.9475 (16.0); 2.8828 (0.8); 2.8815 (0.8); 2.2992 (6.4); 1.2891 (5.9); 1.2723 (5.8); 0.0002 (6.6)
[0645] I-191: .sup.1H-NMR(4(K).0 MHz, CDCl3):
[0646] =7.2600 (39.5); 7.0944 (1.8); 7.0794 (0.9); 7.0603 (1.7); 7.0138 (1.2); 6.9960 (0.8); 4.7653 (0.8); 4.7435 (0.5); 4.5742 (5.0); 4.3065 (0.6); 4.2828 (0.5); 4.1251 (1.1); 4.1120 (2.3); 4.0982 (1.5); 3.8637 (1.8); 3.8491 (2.2); 3.8362 (1.2); 3.2981 (1.0); 3.2810 (1.4); 3.2639 (1.1); 3.0483 (0.6); 3.0292 (0.6); 3.0098 (0.7); 2.9906 (0.7); 2.4921 (0.6); 2.3019 (8.0); 2.2357 (0.6); 1.5921 (1.0); 1.4100 (16.0); 1.3929 (15.8); 1.2915 (7.2); 1.2747 (7.1); -0.0002 (13.8)
[0647] 1H-NMR
[0648] I-192: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0649] =7.0532 (2.3); 7.0344 (3.2); 6.9595 (2.7); 6.9393 (2.3); 6.9274 (4.3); 6.2833 (1.0); 6.2622 (1.0); 4.6172 (1.1); 4.5955 (2.1); 4.5732 (1.1); 4.4547 (4.5); 4.0362 (2.9); 3.9015 (11.4); 3.7920 (2.6); 3.7784 (4.1); 3.7655 (2.1); 3.3426 (278.0); 3.2674 (1.4); 3.1690 (0.9); 2.9640 (1.0); 2.9444 (1.1); 2.9269 (1.2); 2.9081 (1.2); 2.8125 (0.4); 2.7949 (1.0); 2.7808 (1.7); 2.7650 (1.2); 2.7487 (0.4); 2.6722 (0.6); 2.5068 (91.3); 2.5029 (115.0); 2.4991 (87.9); 2.4145 (1.2); 2.3899 (1.6); 2.3766 (1.1); 2.3536 (1.4); 2.3297 (0.8); 2.3028 (0.6); 2.2827 (0.9); 2.2644 (1.1); 2.2453 (1.1); 2.2201 (16.0); 1.2523 (0.4); 1.2360 (0.4); 1.1940 (0.4): 1.1672 (8.8); 1.1507 (8.6); 1.0161 (10.4); 1.0047 (5.7); 0.9975 (5.2); 0.0002 (11.3)
[0650] I-193: .sup.1H-NMR(400.0 MHz, CDCl3):
[0651] =7.2602 (86.5); 7.0900 (3.5); 7.0799 (1.9); 7.0608 (3.3); 7.0158 (2.4); 7.0139 (2.4); 6.9962 (1.8); 4.7884 (0.9); 4.7662 (1.7); 4.7441 (1.0); 4.5583 (9.6); 4.3069 (1.2); 4.2832 (1.1); 4.1221 (2.2); 4.1089 (4.5); 4.0950 (2.8); 3.8540 (3.1); 3.8421 (3.6); 3.8389 (4.0); 3.8257 (2.0); 3.5477 (1.7); 3.5276 (2.6); 3.5074 (1.8); 3.4873 (1.4); 3.0482 (1.2); 3.0290 (1.3); 3.0097 (1.4); 2.9908 (1.4); 2.9551 (1.3); 2.8837 (1.1); 2.8823 (1.1); 2.5146 (0.9); 2.4924 (1.1); 2.4764 (0.8); 2.4549 (1.0); 2.3006 (16.0); 2.2743 (0.6); 2.2519 (0.9); 2.2348 (1.2); 2.2176 (0.9); 2.0510 (1.6); 2.0366 (4.4); 2.0310 (3.2); 2.0173 (5.0); 1.9976 (2.2); 1.8576 (1.0); 1.8456 (1.5); 1.8350 (1.7); 1.8189 (1.4); 1.7079 (0.6); 1.6800 (1.8); 1.6707 (1.2); 1.6670 (1.3); 1.6629 (1.9); 1.6515 (1.7); 1.6439 (0.9); 1.6391 (1.0); 1.6327 (0.8); 1.5932 (1.5); 1.2906 (15.0); 1.2738 (14.6); 0.0079 (0.8); 0.0002 (32.8); 0.0085 (1.0)
[0652] I-194: .sup.1H-NMR(400.0 MHz, CDCl3):
[0653] =7.4161 (0.6); 7.4116 (1.0); 7.4071 (5.1); 7.4017 (5.6); 7.3992 (3.6); 7.3937 (3.8); 7.3893 (5.8); 7.3874 (5.5); 7.3845 (2.5); 7.3829 (3.0); 7.3799 (2.4); 7.3776 (2.5); 7.3737 (5.7); 7.3687 (4.4); 7.3633 (1.5); 7.3602 (2.0); 7.3572 (1.7); 7.3520 (1.0); 7.3476 (1.0); 7.2592 (68.3); 7.0765 (5.2); 7.0581 (3.2); 7.0132 (2.3); 7.0114 (2.3); 6.9950 (1.4); 6.9922 (1.3); 4.7601 (0.9); 4.7379 (1.7); 4.7159 (1.0); 4.3467 (16.0); 4.3209 (6.8); 4.2785 (1.5); 4.2551 (1.2); 3.8081 (1.9); 3.7940 (4.4); 3.7806 (2.5); 3.5483 (2.0); 3.5447 (1.9); 3.5356 (3.3); 3.5303 (3.2); 3.5220 (1.4); 3.5167 (1.5); 3.0410 (1.1); 3.0220 (1.2); 3.0026 (1.3); 2.9836 (1.4); 2.5075 (0.9); 2.4859 (1.0); 2.4695 (0.7); 2.4472 (0.9); 2.2977 (15.2); 2.2608 (0.5); 2.2414 (0.8); 2.2211 (1.1); 2.2040 (0.8); 1.5847 (2.0); 1.2833 (14.0); 1.2665 (13.6); 0.0080 (0.7); 0.0002 (25.4); 0.0085 (0.7)
[0654] I-195: .sup.1H-NMR(400.0 MHz, CDCl3):
[0655] =8.1600 (2.2); 8.1574 (4.0); 8.1549 (2.2); 8.1401 (2.5); 8.1386 (2.8); 8.1367 (2.6); 8.1352 (2.4); 7.5730 (0.5); 7.5640 (7.4); 7.5615 (7.8); 7.5547 (5.1); 7.5530 (5.1); 7.5516 (5.1); 7.5480 (4.2); 7.5281 (0.6); 7.4741 (2.6); 7.4646 (2.3); 7.4616 (1.8); 7.4543 (2.6); 7.4523 (1.9); 7.4460 (2.1); 7.4408 (1.7); 7.4325 (1.7); 7.2602 (53.1); 7.0719 (5.4); 7.0516 (3.3); 7.0084 (2.4); 7.0066 (2.4); 6.9895 (1.3); 6.9876 (1.3); 4.7681 (0.8); 4.7460 (1.6); 4.7241 (1.0); 4.5318 (11.2); 4.3058 (1.1); 4.2825 (1.0); 4.0887 (2.1); 4.0756 (4.3); 4.0617 (3.0); 3.9062 (3.8); 3.8921 (5.0); 3.8792 (2.6); 3.4842 (10.3); 3.0382 (1.2); 3.0190 (1.3); 2.9996 (1.4); 2.9805 (1.4); 2.5038 (0.9); 2.4816 (1.1); 2.4656 (0.8); 2.4430 (1.0); 2.2945 (16.0); 2.2608 (0.6); 2.2439 (0.8); 2.2415 (0.9); 2.2213 (1.2); 2.2042 (0.9); 1.2763 (14.9); 1.2595 (14.5); 0.0002 (19.9); 0.0085 (0.6)
[0656] I-196: .sup.1H-NMR(400.0 MHz, CDCl3):
[0657] =7.2607 (20.8); 7.1843 (1.2); 7.1830 (1.2); 7.1418 (0.7); 7.1228 (1.1); 7.0592 (0.8); 7.0573 (0.8); 7.0554 (0.7); 7.0382 (0.5); 4.4959 (3.9); 4.1628 (0.9); 4.1496 (1.5); 4.1355 (1.1); 3.8158 (1.4); 3.8017 (1.8); 3.7885 (1.2); 3.4859 (3.2); 2.9548 (0.5); 2.9436 (16.0); 2.3300 (5.6); 1.8645 (0.6); 1.8459 (0.6); 1.8330 (0.5); 1.8143 (0.5); 0.0002 (7.7)
[0658] I-197: .sup.1H-NMR(400.0 MHz, CDCl3):
[0659] =7.2606 (29.8); 7.1891 (1.7); 7.1402 (1.0); 7.1211 (1.5);7.0575 (I.I); 7.0557 (I.I); 7.0365 (0.7); 5.1736 (0.5); 5.1541 (0.6); 4.5592 (5.0); 4.1305 (I.I); 4.1175 (2.2); 4.1035 (1.5); 3.8580 (1.8); 3.8441 (2.5); 3.8311 (1.5); 3.4865 (1.2); 3.2911 (1.0); 3.2740 (1.4); 3.2569 (1.1); 2.9541 (0.8); 2.8820 (0.5); 2.8271 (0.6); 2.8072 (0.5); 2.6691 (0.5); 2.6512 (0.5); 2.6496 (0.5); 2.6422 (0.5); 2.3309 (7.7); 1.8659 (0.7); 1.8472 (0.7); 1.8344 (0.7); 1.8157 (0.7); 1.4049 (16.0); 1.3878 (15.9);-0.0002 (11.0)
[0660] I-198: .sup.1H-NMR(400.0 MHz, CDCl3):
[0661] =7.2607 (20.0); 7.2352 (1.5); 6.9943 (4.4); 6.9914 (4.2); 4.4904 (4.1); 4.1531 (0.9); 4.1399 (1.6); 4.1258 (1.1); 3.8112 (1.5); 3.7970 (1.8); 3.7838 (1.2); 3.4856 (2.5); 2.9420 (16.0); 2.7663 (0.6); 2.2804 (6.4); 0.0002 (7.6)
[0662] 1H-NMR
[0663] I-199: .sup.1H-NMR(400.0 MHz, CDCl3):
[0664] =7.2603 (32.7); 7.2432 (1.9); 6.9935 (5.7); 6.9906 (5.4); 4.7815 (0.5); 4.5564 (5.3); 4.3963 (0.6); 4.3755 (0.6); 4.1242 (1.1); 4.1112 (2.2); 4.0973 (1.4); 3.8535 (1.8); 3.8397 (2.5); 3.8266 (1.5); 3.4870 (0.9); 3.2893 (1.0); 3.2722 (1.4); 3.2551 (I.I); 2.7657 (0.7); 2.7245 (0.6); 2.2817 (8.6); 1.9031 (0.5); 1.8955 (0.5); 1.8882 (0.5); 1.6039 (0.6); 1.4041 (16.0); 1.3870 (15.8);-0.0002 (11.9)
[0665] I-200: .sup.1H-NMR(400.0 MHz, CDCl3):
[0666] =7.2607 (47.2); 7.2364 (3.6); 6.9944 (10.9); 6.9916 (10.2); 4.8050 (0.8); 4.7856 (0.9); 4.5448 (10.6); 4.4138 (1.0); 4.3932 (0.9); 4.1536 (2.2); 4.1405 (3.9); 4.1263 (2.7); 3.8496 (3.4); 3.8355 (4.6); 3.8223 (2.9); 3.4855 (2.9); 2.7813 (0.7); 2.7662 (1.3); 2.7511 (0.8); 2.7427 (0.7); 2.7260 (1.0); 2.7091 (0.8); 2.3676 (0.6); 2.3555 (1.4); 2.3478 (1.4); 2.3434 (0.8); 2.3357 (2.8); 2.3279 (0.8); 2.3236 (1.4); 2.3159 (1.5); 2.3038 (0.7); 2.2803 (16.0); 2.0742 (0.8); 2.0626 (0.8); 2.0516 (0.7); 2.0423 (0.7); 2.0304 (0.6); 1.9299 (0.8); 1.9241 (0.8); 1.9153 (0.7); 1.9090 (1.0); 1.9026 (0.5); 1.8946 (0.9); 1.8820 (0.8); 1.8755 (1.0); 1.8622 (0.5); 1.8581 (0.5); 1.8531 (0.6); 1.8457 (0.7); 1.8376 (0.6); 1.8309 (0.8); 1.8223 (0.8); 1.8107 (0.6); 1.8065 (0.6); 1.8031 (0.6); 1.6209 (0.7); 1.2758 (0.6); 1.2733 (0.8); 1.2616 (3.2); 1.2562 (2.9); 1.2536 (2.0); 1.2497 (2.9); 1.2445 (3.5); 1.2330 (1.1); 1.2301 (0.8); 1.0829 (1.0); 1.0801 (1.0); 1.0716 (1.7); 1.0689 (2.9); 1.0632 (3.7); 1.0606 (1.4); 1.0517 (2.5); 1.0491 (3.3); 1.0437 (2.9); 1.0321 (0.8); 1.0294 (0.8); 0.0002 (17.8); 0.0085 (0.5)
[0667] I-201: .sup.1H-NMR(400.0 MHz, CDCl3):
[0668] =7.2602 (70.7); 7.2544 (0.5); 7.2415 (3.6); 6.9934 (11.0); 6.9905 (10.1); 4.8017 (0.9); 4.7821 (1.0); 4.5412 (10.0); 4.3961 (1.1); 4.3751 (1.0); 4.1205 (2.2); 4.1075 (3.9); 4.0934 (2.6); 3.8439 (3.3); 3.8300 (4.6); 3.8169 (2.7); 3.5408 (1.6); 3.5207 (2.4); 3.5003 (1.7); 3.4873 (1.8); 2.7804 (0.7); 2.7654 (1.4); 2.7506 (0.8); 2.7415 (0.7); 2.7252 (1.1); 2.7081 (0.8); 2.2811 (16.0); 2.0751 (0.8); 2.0633 (1.0); 2.0494 (1.3); 2.0441 (2.1); 2.0304 (4.8); 2.0249 (3.2); 2.0110 (4.8); 1.9943 (1.9); 1.9916 (2.2); 1.9461 (0.5); 1.9317 (0.8); 1.9263 (0.8); 1.9170 (0.7); 1.9100 (1.0); 1.9001 (0.9); 1.8943 (1.0); 1.8851 (1.0); 1.8741 (1.1); 1.8583 (1.2); 1.8536 (1.6); 1.8433 (1.8); 1.8312 (2.3); 1.8154 (1.8); 1.7879 (0.8); 1.7047 (0.5); 1.6769 (1.7); 1.6677 (1.2); 1.6639 (1.3); 1.6598 (1.8); 1.6484 (1.6); 1.6408 (0.9); 1.6359 (1.0); 1.6296 (0.8); 1.6167 (0.6); 1.6022 (1.2); 0.0080 (0.8); 0.0002 (26.4); 0.0085 (0.8)
[0669] I-202: .sup.1H-NMR(400.0 MHz, CDCl3):
[0670] =7.4144 (0.6); 7.4104 (1.1); 7.4045 (4.4); 7.3998 (5.0); 7.3973 (3.1); 7.3920 (4.2); 7.3865 (5.4); 7.3845 (4.8); 7.3794 (2.3); 7.3740 (2.5); 7.3696 (5.6); 7.3648 (4.5); 7.3591 (1.6); 7.3568 (2.0); 7.3525 (1.6); 7.3483 (0.9); 7.3439 (1.0); 7.2597 (67.7); 7.2247 (3.6); 6.9923 (10.5); 6.9895 (9.8); 4.7720 (0.8); 4.7536 (0.9); 4.3414 (15.4); 4.3085 (9.4); 3.8160 (2.0); 3.8029 (3.8); 3.7889 (2.5); 3.5388 (3.0); 3.5250 (4.4); 3.5117 (2.6); 3.4872 (6.3); 2.7772 (0.7); 2.7619 (1.3); 2.7469 (0.7); 2.7377 (0.7); 2.7214 (1.1); 2.7043 (0.8); 2.2795 (16.0); 2.0610 (0.8); 2.0498 (0.8); 2.0388 (0.8); 2.0294 (0.7); 2.0042 (2.0); 1.9136 (0.9); 1.9070 (0.9); 1.8960 (1.0); 1.8810 (1.1); 1.8736 (0.9); 1.8657 (1.1); 1.8589 (0.8); 1.8459 (0.7); 1.8318 (0.6); 1.8244 (0.8); 1.8162 (0.8); 1.8000 (0.6); 1.5927 (0.7); 0.0080 (0.7); 0.0002 (25.0); 0.0085 (0.7)
[0671] I-203: .sup.1H-NMR(400.0 MHz, CDCl3):
[0672] =8.1558 (2.1); 8.1532 (3.7); 8.1507 (2.1); 8.1360 (2.4); 8.1344 (2.8); 8.1326 (2.5); 8.1310 (2.3); 7.5617 (6.7); 7.5591 (7.7); 7.5522 (5.0); 7.5504 (5.5); 7.5496 (5.4); 7.5460 (4.2); 7.5260 (0.6); 7.4706 (2.5); 7.4609 (2.3); 7.4585 (1.7); 7.4508 (2.6); 7.4487 (1.9); 7.4422 (2.0); 7.4376 (1.8); 7.4289 (1.6); 7.2830 (0.5); 7.2711 (0.6); 7.2654 (1.3); 7.2647 (1.3); 7.2598 (72.3); 7.2563 (1.3); 7.2554 (1.2); 7.2547 (1.4); 7.2541 (1.4); 7.2499 (0.6); 7.2236 (3.8); 6.9957 (0.6); 6.9860 (11.0); 6.9831 (10.4); 4.7834 (0.9); 4.7633 (1.0); 4.5158 (10.6); 4.3612 (1.1); 4.3405 (1.0); 4.0977 (2.0); 4.0848 (4.0); 4.0708 (2.8); 3.9035 (3.5); 3.8894 (4.6); 3.8765 (2.5); 3.4866 (2.6); 2.7982 (0.5); 2.7713 (0.8); 2.7558 (1.4); 2.7408 (0.8); 2.7324 (0.8); 2.7165 (1.2); 2.6992 (0.8); 2.2737 (16.0); 2.0572 (0.8); 2.0456 (0.8); 2.0348 (0.8); 2.0250 (0.7); 2.0133 (0.6); 1.9170 (0.9); 1.9116 (0.9); 1.9029 (0.8); 1.8963 (1.1); 1.8818 (1.0); 1.8693 (0.9); 1.8628 (1.1); 1.8518 (0.6); 1.8453 (0.6); 1.8402 (0.7); 1.8330 (0.7); 1.8250 (0.7); 1.8185 (0.8); 1.8099 (0.8); 1.7983 (0.7); 1.7909 (0.6); 1.7824 (0.5); 1.6019 (0.7); 0.0080 (0.7); 0.0002 (27.8); 0.0060 (0.5); 0.0085 (0.8)
[0673] 1H-NMR
[0674] I-204: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0675] =7.2569 (4.2); 7.2389 (4.5); 7.1334 (2.1); 7.1298 (2.1); 7.1123 (4.3); 7.0950 (2.7); 7.0913 (2.5); 6.8534 (3.0); 6.8510 (3.2); 6.8346 (5.2); 6.8326 (5.3); 6.8162 (2.6); 6.8137 (2.5); 6.7503 (5.9); 6.7298 (5.4); 6.3340 (4.5); 6.3122 (4.6); 4.7057 (1.3); 4.6923 (2.7); 4.6810 (2.0); 4.6707 (2.6); 4.6572 (1.3); 4.2586 (1.0); 4.2504 (1.3); 4.2305 (3.2); 4.2219 (2.3); 4.2109 (2.6); 4.2025 (2.4); 4.1927 (2.2); 4.1837 (2.7); 4.1781 (2.5); 4.1675 (2.7); 4.1571 (1.0); 4.1493 (1.2); 4.1405 (0.9); 4.0136 (5.4); 3.9990 (9.4); 3.9842 (5.5); 3.9019 (16.0); 3.3233 (169.5); 3.2669 (0.9); 3.2283 (5.8); 3.2147 (5.9); 3.2093 (4.4); 3.2009 (6.1); 3.1743 (1.0); 3.1621 (1.0); 2.6749 (1.0); 2.6704 (1.3); 2.6660 (1.0); 2.5404 (1.2); 2.5057 (187.5); 2.5014 (238.6); 2.4970 (173.1); 2.3323 (1.1); 2.3280 (1.4); 2.3240 (1.1); 2.2869 (1.6); 2.2718 (3.9); 2.2585 (5.3); 2.2454 (3.7); 2.2306 (1.5); 2.0717 (0.5); 2.0624 (0.7); 2.0502 (0.9); 2.0372 (1.6); 2.0283 (1.9); 2.0246 (2.0); 2.0165 (2.5); 2.0045 (2.9); 1.9953 (2.8); 1.9885 (2.5); 1.9804 (2.6); 1.9727 (1.6); 1 9653 (1.6); 1.9537 (1.0); 1.9452 (0.8): 1.9388 (0.7); 1.9304 (0.5); 0.0002 (1.6)
[0676] I-205: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0677] =8.3150 (0.3); 7.2650 (6.0); 7.2476 (8.3); 7.2235 (4.6); 7.2058 (9.6); 7.1876 (4.2); 7.1728 (8.2); 7.1546 (9.7); 7.1356 (6.3); 7.1179 (2.0); 6.1817 (7.0); 6.1592 (7.3); 5.0362 (2.1); 5.0161 (5.6); 4.9959 (5.5); 4.9756 (2.0); 4.0121 (9.1); 3.9975 (16.0); 3.9827 (9.3); 3.9020 (5.3); 3.3231 (243.0); 3.2675 (0.5); 3.2604 (0.4); 3.2295 (9.8); 3.2159 (9.8); 3.2098 (7.0); 3.2021 (10.3); 3.1746 (0.4); 2.9409 (1.8); 2.9334 (2.0); 2.9195 (2.1); 2.9116 (2.2); 2.9019 (3.2); 2.8940 (3.3); 2.8801 (3.3); 2.8723 (3.1); 2.7856 (2.3); 2.7650 (4.8); 2.7449 (3.8); 2.7258 (2.9); 2.7055 (1.7); 2.6747 (1.5); 2.6702 (2.0); 2.5405 (1.5); 2.5055 (280.8); 2.5013 (354.4); 2.4970 (255.2); 2.4650 (2.4); 2.4568 (2.2); 2.4458 (3.3); 2.4375 (3.5); 2.4263 (3.6); 2.4150 (3.7); 2.4070 (3.2); 2.3959 (1.8); 2.3879 (1.5); 2.3280 (2.1); 2.2879 (2.7); 2.2732 (6.5); 2.2596 (8.9); 2.2463 (6.0); 2.2313 (2.5); 1.8376 (1.6); 1.8160 (4.2); 1.8064 (1.8); 1.7951 (4.2); 1.7850 (4.0); 1.7733 (1.8); 1.7642 (3.8); 1.7426 (1.4); 1.2357 (0.4); 0.0000 (2.0)
[0678] I-207: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0679] =7.1154 (3.8); 6.9580 (0.4); 6.9383 (8.9); 6.9153 (0.4); 6.0515 (1.9); 6.0286 (2.0); 4.6299 (0.5); 4.6193 (0.7); 4.5993 (1.1); 4.5783 (0.5); 4.0024 (2.4); 3.9877 (4.2); 3.9728 (2.5); 3.9017 (2.3); 3.3232 (74.1); 3.2246 (2.6); 3.2112 (2.6); 3.2059 (1.9); 3.1973 (2.8); 2.7076 (0.3); 2.6826 (0.8); 2.6696 (1.5); 2.6657 (1.6); 2.6518 (1.2); 2.6338 (1.3); 2.6204 (0.7); 2.5924 (0.4); 2.5055 (81.0); 2.5011 (106.0); 2.4968 (77.2); 2.3320 (0.5); 2.3278 (0.6); 2.3236 (0.5); 2.2834 (0.7); 2.2682 (1.7); 2.2554 (2.4); 2.2418 (1.6); 2.2269 (0.8); 2.2111 (16.0); 1.8926(I.I); 1.8821 (1.8); 1.8716 (1.7); 1.8585 (1.0); 1.8385 (0.5); 1.7528 (0.4); 1.7257 (1.0); 1.7027 (1.0); 1.6847 (0.8); 1.6729 (0.9); 1.6521 (0.8); 1.6327 (0.5); 0.0002 (0.8)
[0680] I-209: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0681] =8.3149 (0.4); 7.3052 (4.8); 7.2902 (5.5); 7.2834 (5.9); 7.2721 (0.6); 7.2144 (1.0); 7.1333 (1.3); 7.1206 (5.3); 7.1155 (9.1); 7.1067 (16.0); 7.0982 (10.9); 7.0921 (6.9); 7.0793 (2.1); 7.0653 (7.1); 7.0581 (5.5); 7.0435 (3.6); 6.9590 (1.0); 6.1107 (6.2); 6.0878 (6.4); 4.6712 (1.6); 4.6610 (2.5); 4.6409 (3.6); 4.6190 (1.7); 4.0007 (8.2); 3.9860 (14.7); 3.9712 (8.6); 3.9018 (7.7); 3.3245 (289.0); 3.2671 (0.4); 3.2236 (8.9); 3.2100 (9.1); 3.1963 (9.6); 3.1687 (0.7); 2.7799 (0.7); 2.7609 (1.1); 2.7380 (2.6); 2.7204 (3.9); 2.7069 (4.4); 2.6901 (4.8); 2.6751 (3.6); 2.6705 (3.0); 2.6660 (2.4); 2.6474 (1.3); 2.5405 (0.7); 2.5055 (262.0); 2.5012 (350.1); 2.4968 (260.8); 2.3322 (1.5); 2.3277 (2.0); 2.2830 (2.4); 2.2678 (5.9); 2.2547 (8.2); 2.2410 (5.7); 2.2263 (2.4); 1.9529 (0.8); 1.9062 (5.6); 1.8967 (6.0); 1.8857 (3.8); 1.8668 (1.8); 1.8458 (0.7); 1.7817 (1.4); 1.7548 (3.5); 1.7362 (3.6); 1.7304 (3.3); 1.7127 (2.8); 1.7043 (3.0); 1.6829 (2.6); 1.6641 (1.8); 1.6405 (0.6); 0.0002 (2.0)
[0682] I-210; .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0683] =7.0972 (2.0); 7.0784 (2.9); 7.0576 (4.0); 6.9909 (2.5); 6.9723 (1.8); 6.1376 (1.9); 6.1153 (2.0); 4.9988 (0.6); 4.9789 (1.5); 4.9585 (1.5); 4.9390 (0.6); 4.0109 (2.2); 3.9962 (4.1); 3.9820 (2.4); 3.9022 (1.2); 3.8993 (1.0); 3.3251 (72.1); 3.2277 (2.6); 3.2169 (2.8); 3.2031 (2.8); 2.8697 (0.6); 2.8470 (0.6); 2.8322 (0.9); 2.8127 (0.9); 2.7212 (0.6); 2.7012 (1.2); 2.6802 (1.1); 2.6628 (1.1); 2.6418 (0.5); 2.5029 (101.6); 2.4989 (97.0); 2.4447 (0.5); 2.4227 (1.0); 2.4142 (0.9); 2.4034 (1.0); 2.3834 (0.4); 2.3296 (0.6); 2.3258 (0.6); 2.2534 (16.0); 1.8106 (0.3); 1.7887 (1.0); 1.7673 (1.0); 1.7588 (1.0); 1.7367 (0.9); 0.0002 (0.4); 0.0027 (0.4)
[0684] 1H-NMR
[0685] I-211: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0686] =7.2640 (3.1); 7.2449 (3.4); 7.1355 (1.6); 7.1317 (1.6); 7.1142 (3.2); 7.0970 (2.0); 7.0933 (1.9); 6.8543 (2.3); 6.8517 (2.4); 6.8355 (3.9); 6.8333 (4.0); 6.8172 (1.9); 6.8145 (1.9); 6.7518 (4.4); 6.7498 (4.3); 6.7315 (4.0); 6.7294 (3.8); 6.3254 (3.7); 6.3037 (3.8); 4.6969 (0.9); 4.6835 (2.0); 4.6728 (1.5); 4.6625 (2.0); 4.6494 (1.0); 4.2564 (0.7); 4.2483 (1.0); 4.2352 (0.8); 4.2283 (2.4); 4.2202 (1.9); 4.2084 (2.0); 4.2000 (1.8); 4.1919 (1.7); 4.1825 (2.0); 4.1769 (2.0); 4.1665 (2.3); 4.1562 (5.3); 4.1440 (4.1); 4.1313 (4.8); 3.9018 (16.0); 3.3218 (148.8); 2.8940 (4.0); 2.8877 (3.2); 2.8808 (3.9); 2.8727 (3.3); 2.8669 (4.4); 2.6747 (0.8); 2.6701 (1.1); 2.6658 (0.8); 2.5233 (3.5); 2.5096 (80.6); 2.5057 (155.8); 2.5012 (200.8); 2.4967 (149.9); 2.3324 (1.0); 2.3279 (1.3); 2.3236 (1.0); 2.0585 (3.9); 2.0531 (3.4); 2.0447 (3.3); 2.0308 (2.8); 2.0190 (2.0); 2.0068 (1.8); 1.9959 (1.8); 1.9884 (1.9); 1.9804 (2.0); 1.9736 (1.3); 1.9656 (1.2); 1.9537 (0.8); 1.9458 (0.7); 1.9389 (0.6); 1.9305 (0.4); 1.7841 (1.5); 1.7733 (2.7); 1.7613 (3.4); 1.7489 (2.6); 0.0002 (8.7)
[0687] I-213: .sup.1H-NMR(400.0 MHz. CDCl3):
[0688] =7.2623 (29.1); 7.2386 (7.9); 7.1354 (2.0); 7.1158 (4.2); 7.1003 (4.5); 7.0814 (2.2); 6.9103 (3.6); 6.8878 (5.9); 6.8668 (3.3); 5.2968 (16.0); 4.8646 (1.4); 4.8528 (2.8); 4.8323 (3.4); 4.8169 (2.0); 4.2825 (4.1); 4.2493 (10.8); 4.2372 (8.2); 4.2243 (10.0); 2.8527 (8.4); 2.8396 (8.4); 2.8254 (9.7); 2.8025 (2.0); 2.7856 (1.2); 2.7738 (2.2); 2.7578 (3.9); 2.7442 (2.3); 2.7192 (2.1); 2.7038 (3.8); 2.6884 (2.4); 2.6605 (1.6); 2.6450 (1.0); 2.2097 (2.3); 2.1952 (5.1); 2.1819 (7.6); 2.1742 (5.4); 2.1685 (5.7); 2.1540 (2.9); 2.0975 (1.4); 2.0746 (2.3); 2.0646 (3.2); 2.0425 (3.4); 2.0365 (2.4); 1.9461 (0.8); 1.9193 (3.0); 1.9025 (5.2); 1.8964 (4.6); 1.8799 (7.6); 1.8653 (9.4); 1.8534 (10.8); 1.8283 (5.4); 1.6900 (1.0); 1.2754 (0.6); 1.2576 (1.4); 1.2397 (0.6); 0.0002 (9.8)
[0689] I-215:1 .sup.1H-NMR(400.0 MHz. CDCl3):
[0690] =7.2612 (59.4); 7.1884 (5.4); 7.1820 (5.7); 7.1631 (5.8); 7.1571 (5.9); 7.0475 (4.1); 7.0271 (6.1); 7.0121 (5.5); 6.8782 (3.4); 6.8714 (3.3); 6.8573 (6.3); 6.8506 (6.1); 6.8362 (3.3); 6.8296 (3.0); 5.2976 (11.1); 4.8270 (3.7); 4.8071 (4.1); 4.2582 (11.6); 4.2456 (11.1); 4.2337 (16.0); 4.2144 (5.9); 2.8612 (10.8); 2.8480 (10.8); 2.8339 (12.4); 2.7956 (2.0); 2.7534 (4.9); 2.7369 (4.9); 2.7210 (5.3); 2.7071 (3.7); 2.6806 (1.8); 2.1994 (6.4); 2.1867 (9.6); 2.1732 (7.5); 2.1584 (4.3); 2.1411 (2.8); 2.1284 (2.6); 2.1174 (3.5); 2.1068 (4.5); 2.0856 (2.9); 2.0431 (1.9); 1.9219 (1.1); 1.8742 (9.1); 1.8616 (12.9); 1.8495 (10.4); 1.8354 (11.5); 1.8186 (8.7); 1.7935 (6.2); 1.6244 (2.6); 1.2758 (0.8); 12579 (2.0); 0.0002 (21.5)
[0691] I-216: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0692] =7.8443 (0.7); 7.5893 (3.8); 7.3122 (3.0); 7.2967 (3.4); 7.2901 (3.6); 7.2788 (0.4); 7.1359 (0.7); 7.1228 (3.2); 7.1175 (5.2); 7.1086 (9.8); 7.1003 (6.3); 7.0938 (4.1); 7.0805 (1.3); 7.0673 (4.4); 7.0605 (3.4); 7.0453 (2.2); 6.1013 (4.0); 6.0783 (4.2); 4.6556 (1.6); 4.6367 (2.2); 4.6158 (1.0); 4.1435 (5.8); 4.1311 (4.6); 4.1187 (6.0); 4.0754 (2.8); 4.0312 (16.0); 3.9018 (6.4); 3.3253 (273.7); 3.2671 (0.7); 3.1684 (0.6); 2.8909 (5.2); 2.8846 (4.0); 2.8775 (5.0); 2.8697 (4.1); 2.8638 (5.5); 2.7820 (0.5); 2.7644 (0.7); 2.7402 (1.6); 2.7227 (2.4); 2.7083 (2.6); 2.6917 (2.9); 2.6757 (2.2); 2.6708 (1.9); 2.6662 (1.6); 2.6492 (0.8); 2.5406 (0.6); 2.5059 (183.6); 2.5016 (238.2); 2.4972 (173.0); 2.3325 (1.1); 2.3283 (1.4); 2.3241 (1.1); 2.0563 (4.5); 1.9549 (0.5); 1.9182 (2.2); 1.9073 (3.6); 1.8977 (3.7); 1.8854 (2.2); 1.8668 (1.1); 1.8455 (0.5); 1.7819 (2.8); 1.7715 (4.0); 1.7561 (6.0); 1.7352 (3.8); 1.7134 (1.9); 1.7027 (2.0); 1.6820 (1.6); 1.6623 (1.1); 1.6390 (0.4); 1.3228 (0.5); 1.2354 (0.3); 0.0002 (3.2)
[0693] I-217: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0694] =7.6503 (0.4); 7.3360 (0.5); 7.3155 (8.4); 7.3046 (13.5); 7.2929 (1.8); 7.2776 (2.0); 7.2665 (1.5); 7.2583 (2.8); 7.2453 (1.5); 7.2375 (0.7); 7.2333 (0.8); 7.2237 (0.5); 7.2151 (1.0); 7.1972 (2.1); 7.1795 (1.0); 7.1633 (1.7); 7.1455 (0.9); 7.1264 (1.2); 7.1097 (1.4); 7.0923 (0.5); 6.3615 (1.1); 6.3398 (1.2); 5.0203 (0.4); 5.0009 (1.1); 4.9815 (1.1); 4.9486 (4.1); 4.9451 (4.3); 4.9203 (0.7); 4.9063 (0.3); 4.1067 (2.2); 4.0885 (4.9); 4.0704 (2.4); 4.0140 (0.4); 3.9019 (16.0); 3.3249 (56.9); 3.1684 (1.5); 3.0540 (2.4); 3.0359 (5.0); 3.0177 (2.3); 2.9939 (0.4); 2.9422 (0.4); 2.9338 (0.4); 2.9211 (0.4); 2.9121 (0.4); 2.9029 (0.6); 2.8949 (0.7); 2.8814 (0.6); 2.8735 (0.6); 2.7838 (0.4); 2.7629 (0.9); 2.7429 (0.8); 2.7243 (0.6); 2.7028 (0.3); 2.6747 (0.5); 2.6703 (0.6); 2.6658 (0.5); 2.6462 (0.4); 2.6312 (0.4); 2.6168 (0.4); 2.5235 (1.9); 2.5101 (42.8); 2.5058 (87.0); 2.5013 (114.9); 2.4967 (85.2); 2.4924 (43.7); 2.4682 (0.8); 2.4597 (0.6); 2.4487 (0.8); 2.4403 (0.8); 2.4291 (0.8); 2.4178 (0.8); 2.4096 (0.7); 2.3986 (0.4); 2.3906 (0.4); 2.3325 (0.5); 2.3280 (0.7); 2.3236 (0.5); 1.8279 (0.8); 1.8183 (0.4); 1.8075 (0.8); 1.7969 (0.8); 1.7862 (0.4); 1.7765 (0.8); 0.0001 (2.3)
[0695] I-218: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0696] =7.7007 (2.8); 7.6322 (1.6); 7.6163 (3.0); 7.5785 (2.1); 7.5593 (1.8); 7.5402 (0.7); 7.2677 (1.6); 7.2494 (2.1); 7.2161 (1.1); 7.1983 (2.5); 7.1801 (1.2); 7.1638 (2.0); 7.1459 (1.0); 7.1252 (1.3); 7.1062 (1.6); 7.0883 (0.6); 6.3748 (1.6); 6.3532 (1.6); 5.0244 (6.8); 5.0113 (1.6); 4.9905 (1.3); 4.9709 (0.5); 4.1112 (2.5); 4.0930 (5.7); 4.0750 (2.7); 3.9018 (16.0); 3.3239 (61.7); 3.1686 (1.4); 3.0695 (2.7);
[0697] 1H-NMR
[0698] 3.0515 (5.7); 3.0333 (2.5); 2.9424 (0.4); 2.9344 (0.5); 2.9207 (0.5); 2.9124 (0.5); 2.9031 (0.7); 2.8951 (0.8); 2.8815 (0.8); 2.8738 (0.7); 2.7821 (0.5); 2.7613 (1.1); 2.7413 (0.9); 2.7218 (0.7); 2.7012 (0.4); 2.6750 (0.6); 2.6705 (0.8); 2.6661 (0.6); 2.5239 (2.4); 2.5103 (54.8); 2.5060 (108.3); 2.5015 (140.2); 2.4969 (102.4); 2.4926 (51.6); 2.4656 (0.8); 2.4572 (0.7); 2.4462 (0.9); 2.4379 (0.9); 2.4348 (0.8); 2.4266 (0.9); 2.4151 (0.9); 2.4071 (0.8); 2.3961 (0.5); 2.3876 (0.4); 2.3328 (0.6); 2.3282 (0.8); 2.3237 (0.6); 1.8484 (0.4); 1.8270 (1.0); 1.8175 (0.4); 1.8066 (1.0); 1.7961 (0.9); 1.7851 (0.4); 1.7756 (0.9); - 0.0002 (3.0)
[0699] I-219: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0700] =7.3118 (2.1); 7.2941 (2.6); 7.2260 (1.5); 7.2090 (3.1); 7.1895 (1.4); 7.1747 (2.6); 7.1540 (3.0); 7.1360 (2.1); 7.1181 (0.7); 6.3538 (2.3); 6.3321 (2.4); 5.0420 (0.6); 5.0219 (1.8); 5.0017 (1.8); 4.9813 (0.6); 4.0553 (3.5); 4.0371 (7.7); 4.0189 (3.7); 3.9017 (16.0); 3.6354 (5.6); 3.6178 (5.7); 3.5919 (0.4); 3.3234 (91.2); 3.1683 (1.0); 2.9787 (3.8); 2.9606 (8.1); 2.9424 (4.0); 2.9321 (0.9); 2.9236 (0.8); 2.9143 (1.1); 2.9060 (1.1); 2.8921 (1.1); 2.8843 (1.0); 2.7978 (0.7); 2.7771 (1.5); 2.7570 (1.2); 2.7380 (1.0); 2.7166 (0.5); 2.6744 (0.6); 2.6703 (0.8); 2.6657 (0.6); 2.5232 (2.6); 2.5056 (100.3); 2.5012 (129.1); 2.4968 (94.5); 2.4682 (1.4); 2.4599 (1.3); 2.4486 (1.2); 2.4372 (1.2); 2.4291 (1.1); 2.4180 (0.6); 2.4100 (0.5); 2.3322 (0.6); 2.3280 (0.8); 2.3233 (0.6); 1.8677 (0.5); 1.8461 (1.4); 1.8370 (0.6); 1.8254 (1.4); 1.8152 (1.3); 1.8035 (0.6); 1.7943 (1.2); 1.7726 (0.4); 1.2157 (0.4); 1.2045 (0.8); 1.1970 (0.8); 1.1853 (1.4); 1.1732 (0.9); 1.1665 (0.9); 1. 1547 (0.5); 1. 1484 (0.4); 0.4521 (1.0); 0.4405 (2.9); 0.4362 (3.6); 0.4267 (2.2); 0.4205 (3.0); 0.4161 (3.4); 0.4069 (1.6); 0.3903 (0.4); 0.3845 (0.4); 0.3714 (0.5); 0.3479 (1.6); 0.3355 (4.2); 0.3266 (3.7); 0.3228 (3.7); 0.3108 (1.1); 0.0003 (1.2)
[0701] I-220: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0702] =7.3169 (2.6); 7.2994 (3.2); 7.2269 (1.8); 7.2094 (3.8); 7.1903 (1.7); 7.1748 (3.2); 7.1562 (3.7); 7.1374 (2.5); 7.1196 (0.9); 6.2958 (3.2); 6.2742 (3.3); 5.0420 (0.8); 5.0221 (2.3); 5.0018 (2.3); 4.9824 (0.8); 4.8776 (0.7); 4.8604 (1.8); 4.8432 (2.6); 4.8257 (1.9); 4.8083 (0.7); 4.0313 (4.2); 4.0132 (9.2); 3.9950 (4.5); 3.9017 (8.4); 3.3217 (72.6); 3.1748 (0.6); 3.1615 (0.6); 2.9575 (0.7); 2.9499 (0.8); 2.9351 (0.9); 2.9271 (1.1); 2.9178 (5.8); 2.9103 (2.0); 2.8997 (10.2); 2.8817 (4.5); 2.7991 (0.9); 2.7783 (1.9); 2.7583 (1.5); 2.7389 (1.2); 2.7182 (0.7); 2.6700 (0.8); 2.5052 (104.6); 2.5011 (134.2); 2.4970 (101.0); 2.4681 (1.8); 2.4598 (1.6); 2.4484 (1.6); 2.4374 (1.6); 2.4289 (1.3); 2.4178 (0.8); 2.4099 (0.7); 2.3279 (0.8); 1.8773 (0.6); 1.8559 (1.6); 1.8462 (0.7); 1.8351 (1.6); 1.8250 (1.6); 1.8137 (0.7); 1.8043 (1.5); 1.7828 (0.5); 1.4002 (15.6); 1.3961 (16.0): 1.3830 (15.6); 1.3789 (15.7); 1.2356 (0.4); 0.0002 (2.4)
[0703] I-221: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0704] =7.3148 (9.2); 7.3039 (16.0); 7.2759 (0.5); 7.2656 (2.8); 7.2547 (1.6); 7.2441 (3.3); 7.2324 (0.8); 7.1237 (0.9); 7.1196 (0.9); 7.1023 (1.8); 7.0852 (1.1); 7.0811 (1.1); 6.8239 (1.3); 6.8055 (2.2); 6.7892 (1.0); 6.7869 (1.1); 6.7392 (2.4); 6.7189 (2.2); 6.4920 (1.5); 6.4704 (1.5); 4.9435 (7.5); 4.7040 (0.5); 4.6906 (1.0); 4.6786 (0.8); 4.6698 (1.0); 4.6561 (0.4); 4.2556 (0.4); 4.2476 (0.5); 4.2278 (1.2); 4.2198 (1.0); 4.2086 (1.0); 4.1995 (0.9); 4.1898 (0.8); 4.1798 (1.1); 4.1739 (1.0); 4.1643 (1.0); 4.1518 (0.4); 4.1463 (0.5); 4.1373 (0.4); 4.1112 (2.6); 4.0931 (5.8); 4.0750 (2.8); 3.3274 (57.0); 3.0544 (2.8); 3.0363 (5.9); 3.0181 (2.6); 2.9940 (4.2); 2.6740 (0.4); 2.6703 (0.6); 2.5404 (42.7); 2.5094 (36.6); 2.5055 (71.9); 2.5010 (93.2); 2.4966 (67.3); 2.3277 (0.5); 2.3233 (0.4); 2.0628 (0.3); 2.0503 (0.6); 2.0402 (0.8); 2.0288 (1.0); 2.0208 (1.1); 2.0085 (1.4); 1.9992 (1.1); 1.9841 (0.6); 1.9735 (0.4); 1.2396 (0.3); 0.0002 (2.0)
[0705] I-223: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0706] =7.3181 (2.2); 7.3005 (2.9); 7.2219 (1.5); 7.2044 (3.4); 7.1862 (1.5); 7.1702 (2.8); 7.1458 (2.3); 7.1266 (2.4); 7.1092 (1.0); 6.3858 (2.6); 6.3642 (2.8); 5.0191 (0.6); 4.9994 (1.9); 4.9794 (1.9); 4.9595 (0.7); 4.0526 (3.3); 4.0344 (7.4); 4.0163 (3.6); 3.9018 (16.0); 3.6073 (4.8); 3.5887 (5.0); 3.3219 (99.0); 3.1685 (0.7); 2.9701 (3.6); 2.9519 (7.8); 2.9337 (4.1); 2.9158 (1.2); 2.9079 (1.4); 2.8938 (1.2); 2.8866 (1.1); 2.7927 (0.7); 2.7724 (1.6); 2.7523 (1.2); 2.7330 (1.0); 2.7122 (0.6); 2.6704 (1.0); 2.5056 (138.4); 2.5013 (173.7); 2.4970 (128.8); 2.4595 (1.7); 2.4511 (1.7); 2.4400 (1.6); 2.4287 (1.6); 2.4204 (1.3); 2.4092 (0.8); 2.4011 (0.7); 2.3280 (1.2); 1.8695 (0.5); 1.8480 (1.4); 1.8381 (0.8); 1.8274 (1.7); 1.8168 (1.8); 1.8057 (1.3); 1.7963 (2.1); 1.7869 (1.2); 1.7759 (1.2); 1.6558 (2.6); 1.6097 (3.2); 1.5860 (3.7); 1.1284 (4.4); 0.9294 (1.8); 0.9026 (1.6); 0.0002 (2.6)
[0707] I-225: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0708] =7.2855 (1.5); 7.2670 (1.5); 7.1379 (0.7); 7.1339 (0.7); 7.1165 (1.5); 7.0993 (0.9); 7.0955 (0.9); 6.8558 (1.0): 6.8533 (1.1): 6.8349 (1.8); 6.8185 (0.9); 6.8161 (0.8); 6.7545 (2.0); 6.7341 (1.8); 6.4730
[0709] 1H-NMR
[0710] (1.5); 6.4512 (1.6); 4.7200 (0.4); 4.7059 (0.9); 4.696 (0.7); 4.6845 (0.9); 4.6707 (0.4); 4.2640 (0.5); 4.2520 (0.4); 4.2440 (1.1); 4.2364 (0.8); 4.2246 (0.9); 4.2160 (0.8); 4.2051 (0.7); 4.1958 (0.9); 4.1890 (0.8); 4.1797 (0.9); 4.1683 (0.3); 4.1619 (0.4); 4.0388 (2.2); 4.0206 (4.9); 4.0024 (2.4); 3.9017 (4.7); 3.3222 (41.8); 3.1811 (16.0); 3.1622 (0.7); 2.9506 (2.3); 2.9324 (4.6); 2.9142 (2.1); 2.6705 (0.4); 2.5057 (55.6); 2.5013 (71.1); 2.4969 (52.9); 2.3283 (0.4); 2.3239 (0.3); 2.0647 (0.6); 2.0539 (0.7); 2.0439 (0.8); 2.0352 (1.0); 2.0215 (1.1); 2.0121 (0.9); 1.9970 (0.5); 1.9860 (0.3); 0.0003 (1.0)
[0711] I-227: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0712] =7.0922 (3.1); 7.0830 (2.6); 6.9950 (1.8); 6.9758 (1.3); 6.2921 (1.8); 6.2700 (1.9); 5.0116 (0.4); 4.9911 (1.2); 4.9708 (1.2); 4.9507 (0.4); 4.0334 (2.3); 4.0152 (5.1); 3.9970 (2.5); 3.9018 (4.6); 3.3197 (38.2); 3.1843 (16.0); 3.1751 (1.2); 3.1615 (0.7); 2.9504 (2.4); 2.9323 (4.9); 2.9140 (2.2); 2.8839 (0.4); 2.8769 (0.4); 2.8634 (0.4); 2.8554 (0.5); 2.8447 (0.6); 2.8385 (0.7); 2.8239 (0.7); 2.8168 (0.6); 2.7335 (0.4); 2.7124 (0.9); 2.6929 (0.8); 2.6744 (0.9); 2.6530 (0.4); 2.5053 (56.4); 2.5009 (72.4); 2.4966 (54.1); 2.4692 (0.7); 2.4576 (0.8); 2.4499 (0.8); 2.4383 (0.8); 2.4268 (0.8); 2.4192 (0.7); 2.4079 (0.4); 2.4007 (0.3); 2.3276 (0.4); 2.3235 (0.3); 2.2547 (11.5); 1.8100 (0.9); 1.8010 (0.4); 1.7888 (0.9); 1.7793 (0.9): 1.7669 (0.4); 1.7580 (0.8); 0.0002 (1.5)
[0713] I-228: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0714] =7.3405 (2.2); 7.3248 (2.5); 7.3184 (2.5); 7.1354 (0.6); 7.1222 (2.4); 7.1168 (3.7); 7.1079 (7.0); 7.0998 (4.4); 7.0929 (2.9); 7.0796 (1.1); 7.0676 (3.2); 7.0607 (2.4); 7.0499 (1.3); 7.0456 (1.5); 6.2803 (3.4); 6.2575 (3.5); 4.6851 (0.7); 4.6666 (1.3); 4.6553 (1.5); 4.6337 (0.7); 4.0434 (4.4); 4.0252 (9.7); 4.0070 (4.6); 3.9018 (16.0); 3.6708 (0.6); 3.6530 (0.7); 3.6361 (3.6); 3.6257 (3.8); 3.6187 (3.9); 3.6082 (3.5); 3.5915 (0.7); 3.5735 (0.6); 3.3213 (108.8); 3.1747 (0.9); 3.1620 (0.9); 2.9728 (4.3); 2.9546 (8.6); 2.9363 (3.8); 2.7859 (0.4); 2.7710 (0.5); 2.7445 (1.2); 2.7265 (1.6); 2.7128 (2.0); 2.6964 (2.1); 2.6804 (1.2); 2.6749 (1.1); 2.6702 (1.3); 2.6663 (1.0); 2.6545 (0.7); 2.6398 (0.3); 2.5232 (3.4); 2.5099 (64.8); 2.5057 (123.6); 2.5013 (157.1); 2.4968 (113.3); 2.4927 (56.1); 2.3325 (0.7); 2.3279 (0.9); 2.3235 (0.7); 1.9844 (0.3); 1.9791 (0.4); 1.9650 (0.8); 1.9576 (1.0); 1.9457 (1.4); 1.9319 (2.4); 1.9206 (2.0); 1.9051 (1.2); 1.8857 (0.7); 1.8182 (0.6); 1.8129 (0.6); 1.7901 (1.5); 1.7711 (1.4); 1.7661 (1.4); 1.7472 (1.0); 1.7324 (0.7); 1.7136 (1.0); 1.6986 (1.0); 1.6937 (1.1); 1.6744 (0.7); 1.2192 (0.4); 1.2119 (0.5); 1.2010 (1.1); 1.1934 (1.0); 1.1820 (1.7); 1.1698 (1.1); 1.1629 (1.1); 1.1509 (0.6); 0.4515 (1.2); 0.4406 (3.4); 0.4361 (4.2); 0.4268 (2.5); 0.4206 (3.5); 0.4160 (3.9); 0.4070 (1.8); 0.3893 (0.4); 0.3847 (0.4); 0.3707 (0.6); 0.3470 (2.0); 0.3348 (4.9); 0.3259 (4.4); 0.3230 (4.1); 0.3109 (1.2); 0.0002 (2.2)
[0715] I-230: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0716] =7.3054 (1.3); 7.2876 (1.7); 7.2282 (1.0); 7.2110 (2.0); 7.1926 (0.9); 7.1776 (1.7); 7.1576 (1.9); 7.1400 (1.3); 7.1219 (0.4); 6.3370 (1.5); 6.3150 (1.6); 5.0462 (0.4); 5.0261 (1.2); 5.0058 (1.2); 4.9860 (0.4); 4.0351 (2.3); 4.0169 (5.0); 3.9987 (2.4); 3.9019 (4.6); 3.3237 (50.4); 3.1840 (16.0); 2.9511 (2.7); 2.9329 (5.0); 2.9145 (2.6); 2.9035 (0.8); 2.8894 (0.8); 2.8817 (0.7); 2.7981 (0.5); 2.7770 (1.0); 2.7568 (0.8); 2.7384 (0.6); 2.7174 (0.4); 2.6749 (0.3); 2.6706 (0.4); 2.6662 (0.3); 2.5057 (57.5); 2.5014 (72.9); 2.4970 (53.8); 2.4720 (1.0); 2.4638 (0.9); 2.4524 (0.8); 2.4410 (0.8); 2.4331 (0.7); 2.4219 (0.4); 2.4139 (0.3); 2.3282 (0.4); 1.8355 (0.9); 1.8264 (0.4); 1.8147 (0.9); 1.8046 (0.8); 1.7929 (0.4); 1.7838 (0.8); 0.0001 (1.3)
[0717] I-231: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0718] =7.1387 (3.0); 6.9620 (0.4); 6.9422 (6.8); 6.2051 (1.8); 6.1821 (1.8); 4.6432 (0.4); 4.6254 (0.7); 4.6126 (0.8); 4.5911 (0.4); 4.0252 (2.3); 4.0070 (5.0); 3.9888 (2.4); 3.9018 (6.8); 3.3215 (61.5); 3.1813 (16.0); 3.1616 (0.5); 2.9456 (2.3); 2.9275 (4.8); 2.9092 (2.1); 2.6901 (0.6); 2.6704 (1.3); 2.6593(1.1); 2.6417 (1.1); 2.6279 (0.6); 2.5992 (0.3); 2.5055 (57.7); 2.5011 (75.2); 2.4967 (56.6); 2.3318 (0.3); 2.3278 (0.4); 2.3239 (0.4); 2.2141 (12.1); 1.9447 (0.4); 1.9281 (0.6); 1.9148 (1.0); 1.9022 (1.4); 1.8903 (0.7); 1.8732 (0.6); 1.8556 (0.4); 1.7529 (0.8); 1.7336 (0.7); 1.7294 (0.7); 1.7099 (0.6); 1.7001 (0.4); 1.6858 (0.6); 1.6581 (0.6); 1.6436 (0.4); 1.6382 (0.3); 0.0002 (0.8)
[0719] I-232: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0720] =7.1197 (2.3); 7.1007 (3.2); 7.0659 (4.1); 7.0144 (2.5); 6.9953 (1.8); 6.7486 (2.4); 6.7266 (2.5); 5.0499 (0.6); 5.0296 (1.6); 5.0096 (1.6); 4.9895 (0.6); 4.3079 (2.8); 4.2959 (2.3); 4.2833 (2.9); 3.9021 (3.5); 3.6604 (2.5); 3.6532 (2.0); 3.6460 (2.4); 3.6388 (2.0); 3.6320 (2.5); 3.3217 (55.1); 3.1745 (0.7); 3.1616 (0.7); 2.8985 (0.5); 2.8915 (0.6); 2.8766 (0.6); 2.8694 (0.6); 2.8599 (0.8); 2.8523 (0.9); 2.8382 (0.9); 2.8308 (0.8); 2.7531 (0.6); 2.7326 (1.2); 2.7133 (1.0); 2.6936 (0.7); 2.6705 (1.0); 2.5054 (91.9); 2.5012 (118.4); 2.4968 (86.3); 2.4723 (1.4); 2.4643 (1.2); 2.4528 (1.1); 2.4413 (1.1); 2.4334 (1.0);
[0721] 1H-NMR
[0722] 2.4221 (0.6); 2.4147 (0.6); 2.3278 (0.7); 2.3236 (0.5); 2.2608 (16.0); 2.1394 (2.2); 2.1261 (1.7); 1.9352 (1.0); 1.9245 (1.7); 1.9125 (2.2); 1.9011 (1.5); 1.8373 (0.5); 1.8156 (1.2); 1.8064 (0.5); 1.7946 (1.2); 1.7847 (1.2); 1.7731 (0.5); 1.7638 (1.1); 1.7420 (0.4); 0.0002 (1.1)
[0723] I-234: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0724] =7.1158 (3.6); 6.9815 (0.4); 6.9620 (8.2); 6.9399 (0.4); 6.6806 (2.0); 6.6580 (2.2); 4.6638 (0.8); 4.6513 (1.0); 4.6296 (0.5); 4.3023 (2.4); 4.2908 (2.2); 4.2785 (2.6); 3.9018 (16.0); 3.6590 (2.2); 3.6452 (2.3); 3.6310 (2.3); 3.3218 (80.9); 2.7269 (0.4); 2.7015 (0.7); 2.6822 (1.2); 2.6707 (1.8); 2.6542 (1.3); 2.6402 (0.7); 2.6126 (0.4); 2.5057 (89.6); 2.5016 (111.0); 2.4979 (86.2); 2.3279 (0.7); 2.3187 (0.6); 2.2192 (13.9); 2.1378 (2.1); 1.9045 (3.4); 1.7803 (0.4); 1.7764 (0.4); 1.7547 (0.9); 1.7353 (0.9); 1.7289 (0.9): 1.7124 (1.0); 1.6982 (0.8); 1.6891 (0.7); 1.6729 (0.7); 1.6518 (0.5); 0.0001 (5.5)
[0725] I-236: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0726] =7.2773 (2.4); 7.2597 (3.5); 7.2460 (1.9); 7.2282 (3.9); 7.2113 (1.8); 7.1960 (3.4); 7.1749 (3.8); 7.1565 (2.5); 7.1388 (0.8); 6.7863 (3.3); 6.7644 (3.4); 5.0840 (0.8); 5.0646 (2.3); 5.0444 (2.3); 5.0245 (0.8); 4.3094 (3.9); 4.2972 (3.2); 4.2846 (4.0); 3.9017 (16.0); 3.6611 (3.4); 3.6545 (2.7); 3.6469 (3.4); 3.6392 (2.8); 3.6326 (3.6); 3.3220 (111.2); 3.1747 (0.5); 3.1621 (0.5); 2.9631 (0.7); 2.9555 (0.8); 2.9417 (0.8); 2.9334 (0.9); 2.9237 (1.2); 2.9160 (1.4); 2.9021 (1.3); 2.8942 (1.3); 2.8181 (0.9); 2.7972 (1.9); 2.7769 (1.5); 2.7578 (1.2); 2.7369 (0.7); 2.6749 (0.6); 2.6704 (0.9); 2.6659 (0.6); 2.5403 (0.4); 2.5235 (3.1); 2.5099 (60.5); 2.5058 (116.8); 2.5013 (150.4); 2.4968 (113.0); 2.4666 (2.1); 2.4552 (1.8); 2.4470 (1.6); 2.4360 (0.9); 2.4280 (0.8); 2.3323 (0.7); 2.3281 (0.9); 2.3238 (0.7); 2.1399 (3.1); 2.1268 (2.4); 1.9378 (1.4); 1.9269 (2.4); 1.9146 (3.0); 1.9026 (2.1); 1.8629 (0.7); 1.8413 (1.8); 1.8317 (0.8); 1.8208 (1.8); 1.8102 (1.7); 1.7991 (0.8); 1.7898 (1.6); 1.7681 (0.6); 0.0080 (0.3); 0.0002 (9.5); 0.0082 (0.5)
[0727] I-237: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0728] =7.2618 (1.8); 7.2430 (1.9); 7.1578 (0.8); 7.1542 (0.9); 7.1368 (1.8); 7.1193 (1.1); 7.1158 (1.1); 6.9162 (2.1); 6.8946 (2.2); 6.8729 (1.2); 6.8705 (1.4); 6.8521 (2.2); 6.8358 (1.0); 6.8333 (1.1); 6.7736 (2.4); 6.7718 (2.4); 6.7532 (2.2); 4.7532 (0.5); 4.7396 (1.1); 4.7276 (0.9); 4.7186 (1.1); 4.7053 (0.5); 4.3122 (2.4); 4.3001 (2.0); 4.2875 (2.4); 4.2652 (0.3); 4.2573 (0.4); 4.2374 (1.2); 4.2294 (1.2); 4.2184 (1.9); 4.2094 (2.2); 4.1950 (1.2); 4.1773 (0.4); 3.9018 (16.0); 3.6652 (2.1); 3.6591 (1.7); 3.6511 (2.1); 3.6433 (1.7); 3.6370 (2.2); 3.3225 (88.5); 3.1745 (1.3); 3.1617 (1.2); 2.6703 (0.6); 2.6659 (0.5); 2.5406 (0.5); 2.5057 (83.8); 2.5012 (107.4); 2.4968 (80.4); 2.3324 (0.5); 2.3279 (0.6); 2.3234 (0.5); 2.1380 (1.9); 2.1252 (1.5); 2.1152 (1.0); 2.1029 (0.6); 2.0909 (0.5); 2.0782 (0.7); 2.0666 (0.9); 2.0568 (0.8); 2.0467 (0.8); 2.0356 (0.5); 2.0233 (0.5); 2.0092 (1.0); 2.0002 (1.0); 1.9948 (0.7); 1.9858 (0.6); 1.9740 (0.6); 1.9661 (0.4); 1.9594 (0.4); 1.9510 (0.3); 1.9366 (0.9); 1.9249 (1.5); 1.9129 (1.8); 1.9024 (1.3); 0.0002 (3.8)
[0729] I-238: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0730] =7.1219 (2.3); 7.1030 (3.2); 7.0644 (4.1); 7.0164 (2.5); 6.9975 (1.7); 6.8310 (2.4); 6.8091 (2.5); 5.0709 (0.6); 5.0512 (1.6); 5.0311 (1.6); 5.0107 (0.6); 4.2074 (2.4); 4.1929 (4.4); 4.1783 (2.5); 3.9020 (2.3); 3.8244 (2.6); 3.8102 (2.4); 3.7955 (2.8); 3.3222 (76.5); 2.9043 (0.5); 2.8968 (0.5); 2.8830 (0.6); 2.8750 (0.6); 2.8657 (0.8); 2.8583 (0.9); 2.8436 (0.9); 2.8369 (0.8); 2.7574 (0.6); 2.7364 (1.2); 2.7162 (1.0); 2.6982 (0.8); 2.6752 (0.8); 2.6706 (0.8); 2.5645 (0.8); 2.5503 (1.9); 2.5364 (2.7); 2.5054 (86.0); 2.5011 (111.4); 2.4968 (82.0); 2.4688 (1.2); 2.4607 (1.2); 2.4493 (1.1); 2.4380(I.I); 2.4300 (0.9); 2.4186 (0.6); 2.4110 (0.5); 2.3322 (0.5); 2.3277 (0.6); 2.3238 (0.5); 2.2593 (16.0); 1.8445 (0.4); 1.8230 (1.2); 1.8136 (0.5); 1.8023 (1.2); 1.7922 (1.2); 1.7804 (0.5); 1.7713 (1.1); 1.7497 (0.4); 0.0001 (0.9)
[0731] I-239: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0732] =7.1009 (3.9); 6.9838 (0.5); 6.9639 (9.0); 6.9401 (0.4); 6.7817 (2.3); 6.7591 (2.4); 4.7050 (0.5); 4.6879 (0.8); 4.6749 (1.1); 4.6541 (0.6); 4.2000 (2.3); 4.1856 (4.1); 4.1711 (2.3); 3.9019 (16.0); 3.8196 (2.4); 3.8053 (2.3); 3.7907 (2.6); 3.3239 (104.7); 3.2672 (0.4); 2.7299 (0.4); 2.7028 (0.8); 2.6840 (1.2); 2.6711 (1.8); 2.6559 (1.4); 2.6419 (0.7); 2.6139 (0.4); 2.5462 (1.8); 2.5405 (2.2); 2.5325 (2.6); 2.5234 (3.2); 2.5096 (45.7); 2.5057 (90.7); 2.5013 (118.5); 2.4969 (86.0); 2.3324 (0.5); 2.3280 (0.7); 2.3235 (0.5); 2.2171 (16.0); 1.9331 (0.7); 1.9194 (1.0); 1.9021 (1.6); 1.8767 (0.9); 1.8586 (0.5); 1.7798 (0.4); 1.7571 (1.0); 1.7377 (1.0); 1.7316 (1.0); 1.7145 (0.9); 1.7016 (0.8); 1.6879 (0.6); 1.6800 (0.7); 1.6638 (0.4); 1.6580 (0.4); 0.0002 (0.8)
[0733] 1H-NMR
[0734] I-241: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0735] =7.2678 (5.3); 7.2494 (11.4); 7.2309 (8.5); 7.2131 (3.7); 7.1973 (7.0); 7.1798 (4.0); 7.1720 (5.5); 7.1530 (5.4); 7.1350 (1.8); 6.8659 (7.2); 6.8440 (7.4); 5.1102 (1.8); 5.0903 (4.9); 5.0699 (4.8); 5.0502 (1.8); 4.2083 (7.0); 4.1938 (12.7); 4.1791 (7.2); 4.0976 (0.8); 4.0848 (0.8); 3.9019 (16.0); 3.8242 (7.6); 3.8096 (6.9); 3.7951 (8.0); 3.3219 (201.5); 3.2671 (1.4); 3.1745 (3.8); 3.1617 (3.8); 2.9692 (1.4); 2.9611 (1.7); 2.9477 (1.7); 2.9395 (1.8); 2.9300 (2.5); 2.9219 (2.8); 2.9083 (2.7); 2.9003 (2.6); 2.8211 (1.9); 2.8006 (4.1); 2.7807 (3.2); 2.7613 (2.5); 2.7407 (1.4); 2.6745 (1.4); 2.6701 (1.8); 2.6655 (1.4); 2.5512 (5.5); 2.5371 (7.8); 2.5230 (9.8); 2.5054 (247.3); 2.5011 (322.8); 2.4968 (236.2); 2.4745 (4.2); 2.4630 (3.4); 2.4518 (3.2); 2.4434 (2.8); 2.4325 (1.6); 2.4242 (1.3); 2.3320 (1.4); 2.3279 (1.8); 2.3235 (1.4); 1.8708 (1.2); 1.8492 (3.5); 1.8395 (1.4); 1.8287 (3.4); 1.8182 (3.3); 1.8072 (1.4); 1.7977 (3.1); 1.7762 (1.0); 1.2351 (0.4); 0.0002 (2.4)
[0736] I-242: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0737] =7.2480 (2.4); 7.2288 (2.6); 7.1591 (1.2); 7.1557 (1.2); 7.1386 (2.4); 7.1205 (1.6); 7.1171 (1.4); 7.0084 (2.8); 6.9867 (2.9); 6.8690 (1.8); 6.8507 (3.1); 6.8318 (1.4); 6.7755 (3.4); 6.7554 (3.1); 4.7822 (0.7); 4.7691 (1.5); 4.7577 (1.1); 4.7478 (1.5); 4.7344 (0.7); 4.2674 (0.3); 4.2595 (0.5); 4.2398 (1.7); 4.2314 (1.9); 4.2203 (2.7); 4.2110 (5.7); 4.1964 (5.7); 4.1816 (3.3); 3.9016 (16.0); 3.8238 (3.0); 3.8094 (2.8); 3.7949 (3.1); 3.3249 (141.4); 3.2669 (0.4); 2.6699 (0.7); 2.5504 (2.2); 2.5369 (3.1); 2.5052 (102.5); 2.5011 (130.8); 2.4969 (95.9); 2.3277 (0.8); 2.3237 (0.6); 2.1031 (0.6); 2.0918 (0.6); 2.0793 (0.9); 2.0678 (1.2); 2.0569 (1.0); 2.0483 (1.0); 2.0371 (0.6); 2.0186 (0.6); 2.0045 (1.3); 1.9952 (1.3); 1.9899 (1.0); 1.9806 (0.8); 1.9690 (0.7): 1.9617 (0.6); 1.9545 (0.5); 0.0004 (0.8)
[0738] I-245: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0739] =7.1134 (2.2); 7.0944 (3.1); 7.0619 (3.7); 7.0073 (2.4); 6.9882 (1.7); 6.5489 (1.8); 6.5269 (1.8); 5.0390 (0.6); 5.0194 (1.5); 4.9990 (1.5); 4.9795 (0.6); 4.2622 (1.8); 4.2440 (3.3); 3.9016 (7.6); 3.5561 (0.8); 3.5475 (0.9); 3.5197 (1.0); 3.5114 (1.0); 3.3317 (123.6); 3.1750 (0.5); 3.1621 (0.4); 3.0322 (0.9); 3.0006 (1.4); 2.9666 (0.9); 2.8881 (0.5); 2.8659 (0.6); 2.8547 (0.8); 2.8492 (0.9); 2.8336 (0.8); 2.8282 (0.8); 2.7442 (0.6); 2.7231 (1.2); 2.7034 (1.0); 2.6841 (0.8); 2.6754 (0.6); 2.6707 (0.8); 2.6661 (0.9); 2.5545 (0.5); 2.5240 (3.4); 2.5063 (89.7); 2.5019 (113.9); 2.4976 (83.5); 2.4729 (1.1); 2.4616 (1.3); 2.4536 (1.1); 2.4422 (1.1); 2.4309 (1.1); 2.4229 (0.9); 2.4119 (0.6); 2.4038 (0.4); 2.3328 (0.5); 2.3286 (0.7); 2.3243 (0.5); 2.2561 (16.0); 2.0609 (1.6); 2.0308 (1.5); 2.0217 (1.6); 2.0081 (0.5); 1.8354 (0.4); 1.8140 (1.1); 1.8045 (0.5); 1.7924 (1.4); 1.7829 (1.4); 1.7694 (0.8); 1.7618 (1.5); 1.7392 (0.8); 1.7318 (0.6): 1.7181 (0.4): -0.0001 (5.3)
[0740] I-246: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0741] =7.1166 (3.9); 6.9744 (0.5); 6.9542 (9.0); 6.9305 (0.5); 6.4798 (2.2); 6.4571 (2.3); 4.6709 (0.5); 4.6543 (0.9); 4.6418 (1.1); 4.6199 (0.5); 4.2514 (2.3); 4.2364 (3.0); 3.9016 (14.4); 3.5505 (0.8); 3.5474 (0.8); 3.5425 (0.8); 3.5148 (0.9); 3.5070 (1.0); 3.3221 (87.5); 3.2671 (0.4); 3.1747 (0.8); 3.1619 (0.8); 3.0361 (0.8); 3.0042 (1.3); 2.9696 (0.8); 2.7221 (0.4); 2.6967 (0.8); 2.6752 (1.6); 2.6703 (1.6); 2.6658 (1.7); 2.6474 (1.4); 2.6341 (0.7); 2.6057 (0.4); 2.5499 (0.4); 2.5100 (49.2); 2.5058 (95.1); 2.5014 (123.6); 2.4969 (93.2); 2.3325 (0.6); 2.3281 (0.8); 2.3237 (0.6); 2.2135 (16.0); 2.0552 (1.7); 2.0184 (1.7); 1.9261 (0.7); 1.9144 (1.0); 1.8943 (1.7); 1.8707 (0.8); 1.7896 (0.4); 1.7751 (0.8); 1.7512 (1.5); 1.7283 (1.6); 1.7095 (1.0); 1.6887 (0.9); 1.6646 (0.8); 1.6452 (0.6); 0.0002 (7.9);-0.0081 (0.5)
[0742] I-247: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0743] =7.2645 (1.8); 7.2453 (2.0); 7.1503 (1.1); 7.1466 (1.1); 7.1290 (2.2); 7.1118 (1.4); 7.1080 (1.4); 6.8652 (1.6); 6.8623 (1.7); 6.8464 (2.8); 6.8439 (2.9); 6.8280 (1.4); 6.8252 (1.4); 6.7671 (3.1); 6.7653 (3.0); 6.7467 (2.9); 6.7312 (2.7); 6.7094 (2.8); 4.7440 (0.6); 4.7304 (1.3); 4.7199 (1.0); 4.7093 (1.3); 4.6963 (0.6); 4.2603 (3.0); 4.2465 (3.7); 4.2385 (3.5); 4.2255 (1.3); 4.2187 (1.2); 4.2119 (2.0); 4.2041 (1.7); 4.1981 (1.6); 4.1846 (1.1); 4.1701 (0.5); 4.0978 (0.6); 4.0847 (0.6); 3.9017 (16.0); 3.5558 (0.8); 3.5473 (1.0); 3.5346 (0.3); 3.5186 (1.0); 3.5108 (1.0); 3.3229 (130.1); 3.2670 (0.6); 3.1748 (2.8); 3.1617 (2.7); 3.0436 (1.0); 3.0117 (1.6); 2.9799 (1.0); 2.6749 (0.5); 2.6704 (0.7); 2.6660 (0.5); 2.5403 (0.4); 2.5235 (3.1); 2.5102 (50.3); 2.5058 (98.5); 2.5013 (127.5); 2.4968 (94.7); 2.4924 (48.8); 2.3325 (0.6); 2.3281 (0.8); 2.3236 (0.7); 2.0902 (0.4); 2.0562 (2.6); 2.0264 (2.4); 2.0185 (2.5); 2.0028 (1.7); 1.9953 (1.2); 1.9883 (0.9); 1.9796 (0.6); 1.9680 (0.6); 1.9607 (0.5); 1.9534 (0.4); 1.7892 (0.4); 1.7791 (0.5); 1.7675 (0.6); 1.7600 (0.7); 1.7530 (0.6); 1.7416 (0.7); 1.7158 (0.4); 1.4258 (0.4); 0.0002 (2.8)
[0744] 1H-NMR
[0745] I-248: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0746] =7.0985 (2.2); 7.0796 (3.2); 7.0549 (3.9); 6.9926 (2.4); 6.9738 (1.7); 6.1306 (2.2); 6.1084 (2.3); 4.9959 (0.6); 4.9760 (1.6); 4.9558 (1.6); 4.9355 (0.6); 4.1547 (3.0); 4.1426 (2.4); 4.1298 (3.1); 3.9015 (12.0); 3.3226 (112.1); 2.8903 (2.7); 2.8837 (2.1); 2.8767 (3.0); 2.8690 (2.6); 2.8632 (3.1); 2.8474 (0.7); 2.8380 (0.9); 2.8303 (0.9); 2.8159 (0.9); 2.8088 (0.8); 2.7237 (0.6); 2.7031 (1.2); 2.6826 (1.0); 2.6751 (0.7); 2.6699 (1.0); 2.6656 (1.2); 2.6438 (0.4); 2.5099 (47.1); 2.5057 (91.3); 2.5013 (118.1); 2.4968 (87.7); 2.4583 (0.9); 2.4505 (0.8); 2.4394 (1.1); 2.4317 (1.1); 2.4201 (1.2); 2.4085 (1.2); 2.4011 (1.1); 2.3898 (0.6); 2.3818 (0.5); 2.3326 (0.6); 2.3282 (0.8); 2.3235 (0.6); 2.2519 (16.0); 2.0614 (2.3); 2.0488 (1.8); 2.0337 (0.8); 1.8069 (0.5); 1.7852 (2.2); 1.7745 (2.1); 1.7639 (3.2); 1.7549 (2.9); 1.7337 (1.9): 1.7118 (0.5); 0.0002 (2.0)
[0747] I-249: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0748] =7.3059 (1.4); 7.2880 (1.6); 7.1498 (0.4); 7.1363 (1.4); 7.1318 (1.6); 7.1274 (1.7); 7.1207 (4.3); 7.1144 (2.3); 7.1095 (1.6); 7.1042 (2.0); 7.0909 (0.7); 7.0822 (2.2); 7.0761 (1.8); 7.0602 (1.1); 6.5334 (2.3); 6.5105 (2.4); 4.7137 (0.5); 4.6951 (0.8); 4.6830 (1.0); 4.6619 (0.5); 4.2478 (2.2); 4.2332 (3.0); 4.2249 (2.1); 3.9018 (16.0); 3.5477 (0.8); 3.5407 (0.8); 3.5349 (0.7); 3.5126 (0.9); 3.5048 (0.9); 3.3217 (113.4); 3.1747 (1.0); 3.1616 (1.0); 3.0425 (0.9); 3.0109 (1.4); 2.9790 (0.8); 2.7783 (0.3); 2.7528 (0.7); 2.7340 (1.1); 2.7209 (1.3); 2.7038 (1.4); 2.6895 (0.7); 2.6751 (0.7); 2.6702 (0.8); 2.6654 (0.8); 2.5475 (0.4); 2.5056 (86.4); 2.5012 (111 .7); 2.4968 (83.3); 2.3323 (0.6); 2.3280 (0.7); 2.3240 (0.6); 2.0545 (1.5); 2.0167 (1.6); 1.9480 (0.7); 1.9359 (1.0); 1.9241 (1.7); 1.9145 (1.6); 1.8969 (0.8); 1.8801 (0.5); 1.7802 (1.3); 1.7585 (1.5); 1.7361 (1.2): 1.7187 (1.1); 1.6990 (0.9); 1.6753 (0.5); 0.0002 (6.6)
[0749] I-250: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0750] =7.2723 (3.3); 7.2547 (4.5); 7.2396 (2.9); 7.2219 (6.1); 7.2042 (2.6); 7.1874 (5.0); 7.1669 (4.8); 7.1459 (3.8); 7.1282 (1.2); 6.5904 (4.2); 6.5685 (4.3); 5.0740 (1.0); 5.0543 (2.9); 5.0345 (2.9); 5.0145 (1.0); 4.2988 (0.6); 4.2628 (3.8); 4.2439 (7.1); 4.2080 (0.4); 3.9017 (16.0); 3.5549 (1.7); 3.5472 (1.9); 3.5191 (2.0); 3.5109 (2.1); 3.3231 (171.9); 3.1680 (0.6); 3.0356 (1.9); 3.0040 (3.2); 2.9716 (2.0); 2.9596 (1.2); 2.9513 (1.2); 2.9379 (1.2); 2.9294 (1.3); 2.9202 (1.8); 2.9122 (1.9); 2.8983 (1.9); 2.8907 (1.8); 2.8079 (1.4); 2.7871 (3.0); 2.7671 (2.4); 2.7478 (1.8); 2.7273 (1.1); 2.6744 (0.9); 2.6704 (1.3); 2.6663 (1.0); 2.5580 (0.8); 2.5536 (0.8); 2.5234 (6.0); 2.5056 (172.8); 2.5014 (220.5); 2.4971 (167.4); 2.4749 (4.1); 2.4663 (3.7); 2.4550 (2.9); 2.4437 (2.6); 2.4354 (2.2); 2.4244 (1.3); 2.4162 (1.1); 2.3323 (1.1); 2.3281 (1.4); 2.3239 (1.1); 2.0602 (3.5); 2.0304 (3.3); 2.0206 (3.6); 1.8611 (0.9); 1.8396 (2.5); 1.8299 (1.1); 1.8188 (2.5); 1.8086 (2.5); 1.7970 (1.6); 1.7876 (2.8); 1.7658 (1.9); 1.7334 (1.4); 1.7215 (0.8); 1.7003 (0.6); 1.2349 (0.4); 0.0080 (0.4); 0.0001 (12.8)
[0751] I-252: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0752] =8.3145 (0.4); 7.2873 (5.6); 7.2706 (6.8); 7.2661 (6.7); 7.2505 (0.4); 7.1595 (1.6); 7.1457 (5.1); 7.1417 (5.8); 7.1296 (12.4); 7.1271 (12.2); 7.1153 (5.6); 7.1104 (6.6); 7.0920 (9.2); 7.0870 (6.8); 7.0704 (4.0); 6.8292 (8.4); 6.8063 (8.7); 4.7482 (1.7); 4.7305 (2.9); 4.7171 (3.9); 4.6960 (1.8); 4.1980 (8.1); 4.1837 (14.6); 4.1690 (8.4); 3.9020 (16.0); 3.8183 (8.8); 3.8041 (8.2); 3.7893 (9.3); 3.3235 (389.3); 3.1744 (0.9); 3.1617 (0.9); 2.8009 (0.8); 2.7833 (1.2); 2.7587 (2.8); 2.7401 (4.5); 2.7285 (4.9); 2.7127 (5.1); 2.6980 (2.6); 2.6702 (3.5); 2.5453 (6.6); 2.5403 (6.2); 2.5317 (9.4); 2.5233 (11.8); 2.5056 (301.6); 2.5012 (391.6); 2.4968 (287.0); 2.3320 (1.6); 2.3278 (2.2); 2.3235 (1.7); 1.9774 (0.9); 1.9565 (2.4); 1.9436 (3.8); 1.9286 (6.1); 1.9028 (3.3); 1.8850 (2.0); 1.8640 (0.8); 1.8135 (1.5); 1.7866 (3.8); 1.7676 (3.8); 1.7624 (3.7); 1.7440 (3.2); 1.7320 (3.2); 1.7184 (2.4); 1.7107 (2.7); 1.6895 (1.6); 1.6707 (0.6); 1.2355 (0.4); 0.0002 (3.2)
[0753] I-253: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0754] =7.3011 (0.9); 7.2893 (1.0); 7.2867 (1.0); 7.1484 (0.3); 7.1395 (0.9); 7.1368 (1.0); 7.1285 (2.1); 7.1249 (2.1); 7.1164 (0.8); 7.1133 (0.9); 7.1044 (0.4); 7.0850 (1.1); 7.0817 (1.0); 7.0708 (0.7); 6.7080 (1.4); 6.6930 (1.5); 4.7035 (0.5); 4.6943 (0.5); 4.2953 (1.6); 4.2871 (1.2); 4.2783 (1.5); 3.8994 (16.0); 3.6520 (1.4); 3.6478 (0.9); 3.6424 (1.3); 3.6373 (0.9); 3.6328 (1.5); 3.3249 (0.4); 3.3044 (18.2); 2.7566 (0.4); 2.7439 (0.6); 2.7351 (0.4); 2.7181 (0.4); 2.7070 (0.7); 2.6970 (0.4); 2.5210 (0.6); 2.5179 (0.8); 2.5148 (0.8); 2.5060 (18.9); 2.5030 (41.8); 2.4999 (58.6); 2.4969 (42.5); 2.4939 (19.7); 2.3840 (0.3); 2.1359 (1.1); 2.1267 (0.8); 2.1212 (0.5); 1.9606 (0.3); 1.9519 (0.4); 1.9477 (0.4); 1.9315 (0.9); 1.9207 (1.1); 1.9121 (1.4); 1.9032 (1.1); 1.7837 (0.5); 1.7804 (0.4); 1.7684 (0.4); 1.7644 (0.4); 1.7525 (0.4); 1.7241 (0.4); 1.7158 (0.4); 1.7016 (0.4); 0.0002 (10.2); 0.0058 (0.4)
[0755] 1H-NMR
[0756] I-254: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0757] =7.1437 (4.0); 6.9603 (0.5); 6.9400 (9.0); 6.9167 (0.4); 6.2125 (2.2); 6.1898 (2.3); 4.6450 (0.5); 4.6277 (0.9); 4.6148 (1.0); 4.5934 (0.5); 4.0457 (3.0); 4.0275 (6.5); 4.0093 (3.1); 3.9017 (8.9); 3.6544 (0.4); 3.6375 (2.8); 3.6315 (2.9); 3.6198 (2.9); 3.6139 (2.9); 3.5968 (0.4); 3.5792 (0.4); 3.3216 (62.8); 3.1736 (0.3); 2.9734 (3.2); 2.9553 (6.6); 2.9370 (2.9); 2.7162 (0.4); 2.6895 (0.8); 2.6704 (1.8); 2.6577 (1.3); 2.6402 (1.4); 2.6271 (0.7); 2.5983 (0.4); 2.5234 (2.0); 2.5058 (87.3); 2.5014 (112.3); 2.4970 (84.3); 2.3452 (0.4); 2.3324 (0.6); 2.3283 (0.7); 2.3235 (0.6); 2.3182 (0.6); 2.2121 (16.0); 1.9451 (0.6); 1.9268 (0.8); 1.9143 (1.3); 1.9056 (1.8); 1.8953 (1.1); 1.8787 (0.8); 1.8608 (0.6); 1.7898 (0.4); 1.7616 (1.1); 1.7425 (1.0); 1.7376 (1.0); 1.7191 (0.7); 1.6998 (0.5); 1.6840 (0.8); 1.6616 (0.8); 1.6387 (0.5); 1.2196 (0.4); 1.2071 (0.8); 1.1995 (0.8); 1.1883 (1.2); 1.1764 (0.8); 1.1696 (0.9); 1.1575 (0.5); 1.1507 (0.3); 0.4557 (0.8); 0.4400 (3.2); 0.4305 (2.0); 0.4244 (2.6); 0.4200 (3.0); 0.4108 (1.4); 0.3751 (0.4); 0.3523 (1.3); 0.3399 (3.7); 0.3310 (3.4); 0.3275 (3.3); 0.3158 (1.0); 0.0002 (2.2)
[0758] I-255: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0759] =7.2964 (1.9); 7.2775 (2.1); 7.1300 (0.9); 7.1260 (1.0); 7.1084 (1.9); 7.0913 (1.2); 7.0876 (1.2); 6.8394 (1.5); 6.8209 (2.4); 6.8046 (1.1); 6.8022 (1.2); 6.7434 (2.6); 6.7247 (2.4); 6.7229 (2.4); 6.5102 (2.3); 6.4885 (2.4); 4.7052 (0.5); 4.6918 (1.2); 4.6794 (0.9); 4.6707 (1.2); 4.6566 (0.6); 4.5344 (0.3); 4.2750 (0.4); 4.2671 (0.6); 4.2554 (0.5); 4.2473 (1.3); 4.2393 (1.1); 4.2277 (1.0); 4.2192 (0.9); 4.2008 (0.8); 4.1918 (1.1); 4.1857 (1.1); 4.1756 (1.1); 4.1646 (0.5); 4.1579 (0.6); 4.1495 (0.4); 4.0578 (2.6); 4.0396 (5.8); 4.0215 (2.8); 3.9019 (16.0); 3.6218 (0.3); 3.6029 (2.7); 3.5846 (2.9); 3.5700 (0.4); 3.3223 (96.3); 3.1733 (0.5); 3.1633 (0.5); 2.9708 (2.6); 2.9526 (5.3); 2.9344 (2.4); 2.7896 (0.3); 2.6748 (0.5); 2.6704 (0.7); 2.6660 (0.5); 2.5233 (1.9); 2.5057 (98.3); 2.5013 (130.3); 2.4969 (99.7); 2.3324 (0.6); 2.3281 (0.8); 2.3238 (0.7); 2.0766 (0.4); 2.0638 (0.7); 2.0536 (0.9); 2.0423 (1.2); 2.0302 (1.3); 2.0222 (1.6); 2.0138 (1.2); 1.9987 (0.7); 1.9876 (0.5); 1.9795 (0.3); 1.8026 (0.6); 1.7921 (0.6); 1.7835 (0.8); 1.7752 (0.7); 1.7640 (0.6); 1.7557 (0.6); 1.6568 (2.0); 1.6087 (2.3); 1.5849 (2.9); 1.1754 (0.3); 1.1277 (3.4); 1.1107 (2.0); 0.9572 (0.7); 0.9290 (1.5); 0.9007 (1.2); 0.0002 (1.8)
[0760] I-256: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0761] =7.1025 (4.3); 7.0764 (3.3); 6.9887 (2.5); 6.9698 (1.8); 6.8367 (0.4); 6.3308 (2.5); 6.3093 (2.7); 4.9860 (0.6); 4.9663 (1.7); 4.9462 (1.7); 4.9259 (0.6); 4.0517 (2.9); 4.0334 (6.4); 4.0154 (3.2); 3.9019 (12.4); 3.8126 (0.7); 3.6105 (4.1); 3.5918 (4.2); 3.4995 (0.6); 3.3215 (96.3); 3.1750 (1.4); 3.1619 (1.4); 2.9703 (3.2); 2.9522 (6.6); 2.9340 (3.0); 2.8838 (0.6); 2.8691 (0.6); 2.8616 (0.7); 2.8516 (0.9); 2.8447 (1.0); 2.8299 (0.9); 2.8230 (0.9); 2.7294 (0.6); 2.7091 (1.2); 2.6886 (1.0); 2.6705 (1.7); 2.6500 (0.5); 2.5058 (121.7); 2.5015 (152.7); 2.4972 (113.6); 2.4661 (1.3); 2.4578 (1.1); 2.4465 (1.3); 2.4382 (1.3); 2.4271 (1.3); 2.4155 (1.3); 2.4079 (1.2); 2.3969 (0.8); 2.3890 (0.6); 2.3283 (1.0); 2.2496 (16.0); 1.8458 (0.6); 1.8239 (1.5); 1.8140 (1.1); 1.8028 (1.9); 1.7929 (2.1); 1.7817 (1.4); 1.7722 (1.8); 1.7505 (0.7); 1.6584 (2.3); 1.6178 (2.7); 1.5906 (3.3); 1.2646 (1.1); 1.2473 (1.2); 1.2360 (0.7); 1.1317 (4.1); 1.1153 (2.5); 0.9359 (1.6); 0.9067 (1.4); 0.8548 (0.9); 0.8387 (0.8); 0.0000 (3.2)
[0762] I-258: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0763] =7.8158 (1.7); 7.7954 (1.2); 7.7786 (0.7); 7.6189 (0.5); 7.5990 (0.8); 7.5804 (0.3); 7.3413 (0.4); 7.3277 (0.5); 7.3182 (0.5); 7.1126 (0.7); 7.1012 (1.4); 7.0906 (1.1); 7.0787 (1.1); 7.0710 (0.8); 7.0537 (1.2); 7.0448 (1.0); 7.0398 (1.0); 7.0217 (0.6); 7.0021 (0.9); 6.9818 (0.5); 5.8925 (0.8); 5.8699 (0.8); 4.0080 (0.4); 3.9611 (0.6); 3.9471 (1.0); 3.9336 (0.5); 3.9281 (0.5); 3.9017 (16.0); 3.8721 (0.3); 3.8509 (0.4); 3.7668 (0.6); 3.7520 (1.2); 3.7367 (0.6); 3.3204 (14.8); 3.1861 (0.7); 3.1740 (0.6); 2.7133 (0.3); 2.6744 (0.6); 2.6699 (0.7); 2.6291 (0.5); 2.6152 (0.5); 2.6019 (0.5); 2.5052 (64.0); 2.5010 (82.4); 2.4968 (61.5); 2.3274 (0.7); 2.3234 (0.7); 2.3054 (0.6); 2.2960 (0.6); 2.2805 (0.4); 1.9723 (0.5); 1.9580 (0.7); 1.9439 (0.6); 1.9087 (0.4); 1.8958 (0.5); 1.8849 (0.5); 1.8727 (0.3); 1.7768 (0.4); 1.7533 (0.5); 1.7350 (0.4); 1.6491 (0.3); 1.6223 (0.4); 1.6159 (0.3); 1.5176 (0.5); 1.4987 (0.6); 1.4787 (0.4); 0.0003 (1.2 )
[0764] 1H-NMR
[0765] I-259: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0766] =7.3431 (1.1); 7.3278 (1.0); 7.3205 (1.1); 7.1098 (1.6); 7.1009 (2.7); 7.0922 (2.0); 7.0873 (1.3); 7.0753 (0.4); 7.0688 (0.3); 7.0589 (1.3); 7.0507 (1.0); 7.0370 (0.7); 6.2175 (1.3); 6.1950 (1.4); 4.6664 (0.6); 4.6554 (0.6); 3.9431 (1.4); 3.9276 (3.0); 3.9122 (1.6); 3.9020 (16.0); 3.8736 (0.8); 3.8596 (1.3); 3.8461 (0.9); 3.8359 (1.4); 3.8218 (0.8); 3.8027 (0.4); 3.5783 (0.5); 3.5706 (0.6); 3.5599 (1.0); 3.5468 (0.6); 3.5393 (0.5); 3.3199 (25.2); 3.1748 (0.5); 3.1620 (0.5); 2.7392 (0.5); 2.7203 (0.7); 2.7074 (0.9); 2.6927 (0.9); 2.6754 (0.7); 2.6704 (0.7); 2.5056 (67.7); 2.5014 (85.5); 2.4973 (63.4); 2.3281 (0.5); 2.1005 (0.4); 2.0857 (1.3); 2.0711 (1.9); 2.0568 (1.4); 2.0416 (0.6); 1.9440 (0.6); 1.9312 (1.1); 1.9197 (1.0); 1.9039 (0.6); 1.8836 (0.4); 1.8094 (0.7); 1.7855 (0.6); 1.7661 (0.3); 1.7125 (0.4); 1.6936 (0.5); 1.6727 (0.3); 0.9053 (0.4); 0.8929 (1.4); 0.8860 (2.4); 0.8811 (2.1); 0.8745 (2.2); 0.8589 (1.2); 0.8524 (2.3); 0.8450 (1.4); 0.8325 (2.1); 0.8255 (1.2); 0.8130 (0.5); 0.0002 (1.5)
[0767] I-261: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0768] =7.3621 (0.9); 7.3455 (0.9); 7.3398 (0.8); 7.1301 (0.7); 7.1248 (1.2); 7.1159 (2.0); 7.1076 (1.4); 7.1013 (0.9); 7.0883 (0.4); 7.0768 (1.0); 7.0699 (0.7); 7.0547 (0.4); 6.1692 (0.9); 6.1466 (1.0); 4.7237 (0.4); 4.7124 (0.4); 3.9113 (1.3); 3.9019 (16.0); 3.8968 (2.7); 3.8811 (1.3); 3.8538 (0.7); 3.8463 (0.5); 3.8323 (0.8); 3.8200 (1.5); 3.8055 (1.4); 3.7931 (0.6); 3.3210 (27.7); 3.1747 (0.3); 2.7376 (0.5); 2.7218 (0.5); 2.7038 (0.6); 2.6750 (0.4); 2.6704 (0.5); 2.6661 (0.5); 2.5236 (1.2); 2.5059 (58.8); 2.5015 (76.3); 2.4970 (55.7); 2.3324 (0.4); 2.3281 (0.5); 2.3237 (0.4); 2.0748 (0.4); 2.0602 (1.0); 2.0459 (1.4); 2.0317 (1.0); 2.0182 (0.4); 1.9533 (0.5); 1.9383 (0.7); 1.9299 (0.8); 1.8205 (1.0); 1.8022 (1.3); 1.7794 (0.5); 1.6995 (1.0); 1.6917 (1.1); 1.6701 (1.1); 1.6140 (0.5); 1.5905 (0.5); 1.3355 (0.6); 1.3288 (0.5); 1.3070 (0.8); 1.2994 (0.7); 1.2769 (0.8); 1.2581 (0.7); 1.2492 (0.7); 1.2360 (1.0); 1.2058 (0.8); 1.1836 (0.9); 0.0002 (1.4)
[0769] I-262: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0770] =7.3455 (1.0); 7.3307 (1.1); 7.3235 (1.2); 7.1225 (1.2); 7.1176 (2.0); 7.1087 (3.5); 7.1003 (2.5); 7.0943 (1.5); 7.0818 (0.5); 7.0681 (1.5); 7.0604 (1.1); 7.0513 (0.6); 7.0454 (0.7); 6.2218 (1.6); 6.1991 (1.6); 4.8625 (0.4); 4.8455 (1.0); 4.8282 (1.4); 4.8108 (1.0); 4.7938 (0.4); 4.6818 (0.3); 4.6628 (0.6); 4.6501 (0.7); 4.6296 (0.4); 4.0187 (2.2); 4.0006 (5.0); 3.9825 (2.4); 3.9019 (16.0); 3.3217 (66.1); 2.9107 (2.5); 2.8926 (5.3); 2.8744 (2.3); 2.7467 (0.6); 2.7300 (0.8); 2.7144 (0.9); 2.6966 (1.0); 2.6804 (0.6); 2.6745 (0.5); 2.6702 (0.7); 2.6546 (0.4); 2.5100 (32.6); 2.5056 (65.4); 2.5011 (85.8); 2.4966 (62.2); 2.4922 (30.5); 2.3320 (0.3); 2.3278 (0.5); 2.3234 (0.4); 1.9638 (0.4); 1.9446 (0.7); 1.9332 (1.3); 1.9209 (1.2); 1.9069 (0.6); 1.8875 (0.4); 1.8317 (0.3); 1.8031 (0.8); 1.7839 (0.6); 1.7792 (0.7); 1.7602 (0.4); 1.7124 (0.5); 1.6971 (0.5); 1.6731 (0.3); 1.3997 (7.3); 1.3924 (7.6); 1.3824 (7.4); 1.3751 (7.2); 0.0002 (2.2)
[0771] I-264: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0772] =7.2989 (2.8); 7.2804 (3.1); 7.1348 (1.4); 7.1316 (1.4); 7.1145 (2.9); 7.0966 (1.8); 6.8534 (2.0); 6.8518 (2.0); 6.8347 (3.5); 6.8164 (1.7); 6.7522 (4.0); 6.7319 (3.6); 6.4323 (3.2); 6.4108 (3.3); 4.8667 (0.7); 4.8497 (1.8); 4.8325 (2.4); 4.8152 (1.8); 4.7982 (0.7); 4.7153 (0.8); 4.7019 (1.8); 4.6914 (1.3); 4.6810 (1.8); 4.6675 (0.8); 4.2776 (0.6); 4.2686 (0.8); 4.2579 (0.8); 4.2496 (1.9); 4.2403 (1.6); 4.2312 (1.5); 4.2215 (1.3); 4.2045 (1.2); 4.1909 (1.8); 4.1790 (1.6); 4.1615 (0.9); 4.1522 (0.6); 4.0349 (4.0); 4.0168 (8.6); 3.9987 (4.2); 3.9018 (6.4); 3.3213 (75.6); 3.1728 (1.0); 3.1640 (0.9); 2.9169 (4.4); 2.8988 (9.1); 2.8807 (4.1); 2.6706 (0.8); 2.5050 (115.0); 2.5012 (139.7); 2.4973 (104.7); 2.3279 (0.8); 2.0918 (0.4); 2.0794 (0.4); 2.0667 (1.0); 2.0532 (2.0); 2.0377 (3.2); 2.0274 (2.5); 2.0139 (1.0); 2.0037 (0.5); 1.9922 (0.3); 1.9889 (0.3); 1.3998 (15.9); 1.3963 (15.7); 1.3826 (16.0); 1.3791 (15.4); 1.2355 (0.3); 0.0002 (2.1)
[0773] 1H-NMR
[0774] I-266: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0775] =7.7076 (4.9); 7.6350 (3.0); 7.6164 (5.9); 7.5780 (3.4); 7.5590 (3.0); 7.5404 (1.3); 7.3628 (0.4); 7.3440 (0.5); 7.3027 (2.6); 7.2858 (2.9); 7.2833 (2.9); 7.1270 (0.8); 7.1127 (2.2); 7.1092 (2.4); 7.0948 (4.0); 7.0909 (4.5); 7.0699 (3.0); 7.0573 (4.1); 7.0401 (1.9); 6.3045 (3.2); 6.2817 (3.4); 5.0616 (0.8); 5.0222 (6.1); 5.0143 (6.1); 4.9747 (0.7); 4.6816 (0.7); 4.6636 (1.3); 4.6513 (1.5); 4.6299 (0.7); 4.0971 (4.0); 4.0790 (8.6); 4.0609 (4.1); 3.9019 (16.0); 3.3256 (273.4); 3.2672 (0.5); 3.1746 (0.8); 3.1627 (0.7); 3.0619 (4.1); 3.0439 (8.6); 3.0258 (3.9); 3.0117 (0.4); 2.9461 (0.4); 2.7593 (0.5); 2.7318 (1.1); 2.7132 (1.7); 2.7012 (2.0); 2.6853 (2.1); 2.6747 (1.9); 2.6707 (2.3); 2.6434 (0.5); 2.5058 (171.2); 2.5015 (221.5); 2.4972 (168.6); 2.3939 (0.4); 2.3326 (1.1); 2.3283 (1.5); 2.3240 (1.2); 2.0576 (0.3); 2.0425 (0.4); 1.9553 (0.4); 1.9271 (1.7); 1.9131 (2.7); 1.9019 (2.7); 1.8877 (1.5); 1.8697 (0.8); 1.8494 (0.4); 1.7980 (0.7); 1.7741 (1.6); 1.7548 (1.4); 1.7322 (1.0); 1.7164 (0.9); 1.6971 (1.1); 1.6923 (1.0); 1.6814 (1.2); 1.6593 (0.8); 1.6359 (0.4); 1.2355 (0.6); 0.8525 (0.3); 0.0003 (1.3)
[0776] I-267: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0777] =7.4868 (0.4); 7.4777 (2.8); 7.4711 (2.0); 7.4672 (2.4); 7.4601 (2.1); 7.4547 (3.7); 7.4468 (0.6); 7.4355 (0.4); 7.3369 (0.3); 7.3338 (0.3); 7.3260 (0.5); 7.3196 (1.0); 7.3057 (4.6); 7.3013 (3.6); 7.2950 (5.5); 7.2875 (5.8); 7.2829 (7.7); 7.2684 (3.5); 7.2640 (3.3); 7.1990 (2.8); 7.1933 (1.7); 7.1865 (2.2); 7.1756 (1.9); 7.1136 (0.8); 7.0995 (2.4); 7.0957 (2.5); 7.0821 (4.9); 7.0766 (5.1); 7.0622 (2.6); 7.0579 (3.1); 7.0429 (4.4); 7.0245 (2.0); 6.2986 (3.5); 6.2759 (3.6); 4.9785 (11.7); 4.6370 (0.7); 4.6189 (1.3); 4.6066 (1.6); 4.5855 (0.8); 4.4646 (0.4); 4.4502 (0.4); 4.1727 (4.2); 4.1546 (9.4); 4.1365 (4.4); 4.0134 (0.5); 3.9018 (16.0); 3.6098 (2.4); 3.3239 (204.1); 3.1747 (1.0); 3.1618 (1.0); 3.1314 (4.5); 3.1134 (9.6); 3.0952 (4.2); 2.7546 (0.5); 2.7382 (1.0); 2.7205 (0.7); 2.7121 (1.2); 2.6928 (2.1); 2.6838 (2.1); 2.6701 (3.4); 2.6268 (0.6); 2.5233 (3.6); 2.5098 (77.9); 2.5056 (153.0); 2.5012 (198.0); 2.4967 (145.4); 2.4925 (73.8); 2.3323 (0.9); 2.3279 (1.2); 2.3234 (0.9); 1.9418 (0.4); 1.9200 (1.0); 1.9068 (1.5); 1.8902 (2.6); 1.8648 (1.4); 1.8456 (0.8); 1.7679 (0.6); 1.7634 (0.6); 1.7407 (1.6); 1.7215 (1.6); 1.7161 (1.5); 1.6981 (1.4); 1.6841 (1.4); 1.6694 (1.0); 1.6603 (1.2); 1.6463 (0.7); 0.0002 (1.6)
[0778] I-270: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0779] =7.4870 (0.4); 7.4781 (2.5); 7.4717 (1.9); 7.4684 (2.0); 7.4602 (1.9); 7.4551 (3.3); 7.4475 (0.5); 7.3256 (0.5); 7.3196 (0.8); 7.3040 (4.0); 7.2941 (4.9); 7.2862 (4.0); 7.2834 (4.3); 7.2815 (4.2); 7.2682 (0.9); 7.2627 (0.5); 7.2379 (2.8); 7.2190 (3.0); 7.1979 (2.7); 7.1843 (2.0); 7.1747 (1.7); 7.1124 (1.4); 7.1087 (1.4); 7.0913 (2.8); 7.0739 (1.8); 7.0702 (1.7); 6.8131 (2.0); 6.8108 (2.1); 6.7923 (3.5); 6.7759 (1.7); 6.7735 (1.7); 6.7259 (3.8); 6.7056 (3.6); 6.4955 (3.3); 6.4739 (3.4); 4.9803 (11.0); 4.6693 (0.8); 4.6555 (1.7); 4.6443 (1.3); 4.6346 (1.7); 4.6215 (0.8); 4.2278 (0.5); 4.2195 (0.7); 4.1993 (2.1); 4.1891 (5.0); 4.1708 (10.8); 4.1600 (2.7); 4.1525 (5.3); 4.1379 (0.7); 4.1316 (0.8); 4.1227 (0.5); 3.9018 (16.0); 3.3252 (166.1); 3.1685 (0.6); 3.1373 (4.2); 3.1192 (8.8); 3.1011 (3.9); 2.6750 (0.6); 2.6704 (0.9); 2.6660 (0.7); 2.5057 (120.5); 2.5013 (153.6); 2.4969 (113.5); 2.3324 (0.7); 2.3281 (0.9); 2.3236 (0.7); 2.0572 (0.5); 2.0455 (0.6); 2.0327 (1.0); 2.0225 (1.3); 2.0114 (1.4); 2.0005 (1.2); 1.9916 (1.3); 1.9839 (1.2); 1.9781 (1.5); 1.9696 (1.6); 1.9634 (1.1); 1.9547 (1.0); 1.9434 (0.7); 1.9354 (0.6); 1.9285 (0.5); 1.1800 (0.4); 0.0002 (1.3)
[0780] I-271: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0781] =7.3393 (2.2); 7.3229 (2.5); 7.3178 (2.4); 7.1309 (0.6); 7.1169 (2.0); 7.1129 (2.3); 7.1073 (2.3); 7.1013 (5.5); 7.0955 (3.2); 7.0894 (2.4); 7.0847 (2.6); 7.0712 (1.0); 7.0624 (3.0); 7.0567 (2.4); 7.0409 (1.5); 6.3081 (3.0); 6.2853 (3.1); 4.6681 (0.7); 4.6492 (1.2); 4.6381 (1.4); 4.6166 (0.7); 4.0402 (3.7); 4.0220 (8.1); 4.0039 (3.9); 3.9018 (16.0); 3.6038 (4.7); 3.5852 (4.9); 3.3225 (107.0); 3.1671 (0.3); 2.9644 (3.3); 2.9465 (6.4); 2.9282 (2.9); 2.7821 (0.3); 2.7679 (0.5); 2.7405 (1.0); 2.7228 (1.6); 2.7088 (1.8); 2.6913 (1.9); 2.6752 (1.6); 2.6707 (1.4); 2.6664 (1.1); 2.6501 (0.6); 2.5058 (132.2); 2.5015 (166.4); 2.4972 (123.3); 2.3283 (1.0); 2.3238 (0.8); 1.9460 (1.5); 1.9312 (2.6); 1.9197 (2.4); 1.9050 (1.3); 1.8866 (0.8); 1.8671 (0.4); 1.8109 (1.2); 1.7880 (2.3); 1.7652 (2.1); 1.7462 (1.4); 1.7291 (1.0); 1.7097 (1.1); 1.6674 (2.9); 1.6575 (3.0); 1.6095 (3.3); 1.5845 (3.9); 1.2363 (0.4); 1.1299 (4.6); 0.9565 (1.0); 0.9288 (2.0); 0.9030 (1.7); 0.8743 (0.7); 0.0002 (2.9)
[0782] 1H-NMR
[0783] I-273: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0784] =8.3149 (0.3); 7.7053 (5.0); 7.6375 (2.9); 7.6167 (5.6); 7.5788 (3.5); 7.5595 (3.0); 7.5405 (1.1); 7.2539 (3.0); 7.2348 (3.1); 7.1261 (1.4); 7.1222 (1.5); 7.1048 (2.8); 7.0875 (1.8); 7.0837 (1.8); 7.0561 (0.4); 7.0418 (0.3); 7.0222 (0.4); 6.8261 (2.0); 6.8234 (2.2); 6.8073 (3.5); 6.8050 (3.6); 6.7889 (1.8); 6.7862 (1.8); 6.7423 (4.0); 6.7400 (3.9); 6.7218 (3.7); 6.7196 (3.4); 6.5115 (3.2); 6.4898 (3.3); 5.0629 (0.7); 5.0234 (6.3); 5.0172 (6.4); 4.9778 (0.6); 4.7129 (0.8); 4.6991 (1.7); 4.6871 (1.3); 4.6776 (1.7); 4.6642 (0.8); 4.5505 (0.4); 4.5346 (0.6); 4.5183 (0.5); 4.4867 (0.3); 4.2559 (0.6); 4.2475 (0.9); 4.2357 (0.8); 4.2278 (2.0); 4.2198 (1.7); 4.2083 (1.6); 4.1998 (1.4); 4.1878 (1.3); 4.1782 (1.7); 4.1725 (1.7); 4.1624 (1.7); 4.1513 (0.8); 4.1443 (1.0); 4.1358 (0.8); 4.1142 (4.2); 4.0960 (9.3); 4.0779 (4.5); 4.0636 (0.7); 4.0573 (0.4); 4.0458 (0.6); 3.9850 (0.4); 3.9019 (16.0); 3.3235 (73.8); 3.2674 (0.9); 3.1686 (4.6); 3.0690 (4.3); 3.0510 (9.3); 3.0328 (4.1); 2.8064 (0.4); 2.7901 (0.5); 2.7742 (0.4); 2.7020 (0.4); 2.6750 (0.9); 2.6704 (1.3); 2.6660 (0.9); 2.5237 (3.8); 2.5102 (84.0); 2.5059 (168.7); 2.5014 (220.6); 2.4969 (161.9); 2.4925 (81.6); 2.3373 (0.5); 2.3326 (1.0); 2.3281 (1.3); 2.3236 (1.0); 2.0722 (0.4); 2.0605 (0.5); 2.0472 (1.0); 2.0369 (1.4); 2.0253 (1.7); 2.0144 (2.0); 2.0065 (2.3); 1.9979 (1.9); 1.9831 (1.1); 1.9718 (0.7); 1.9634 (0.5); 1.9572 (0.5); 1.9486 (0.3); 1.2747 (0.4); 1.2590 (0.7); 1.2437 (0.6); 1.2351 (0.4): 1.1789 (0.7); 1.1608 (1.3); 1.1430 (0.6); 0.0002 (5.4)
[0785] I-277: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0786] =7.2935 (4.9); 7.2762 (5.3); 7.1350 (2.5); 7.1313 (2.4); 7.1138 (5.0); 7.0965 (3.2); 7.0928 (2.9); 6.8524 (3.7); 6.8498 (3.6); 6.8336 (6.2); 6.8315 (6.0); 6.8152 (3.1); 6.8126 (2.9); 6.7516 (7.1); 6.7313 (6.4); 6.4864 (5.6); 6.4647 (5.7); 4.7215 (1.5); 4.7079 (3.1); 4.6948 (2.3); 4.6867 (3.0); 4.6729 (1.4); 4.2749 (1.1); 4.2667 (1.5); 4.2549 (1.4); 4.2470 (3.6); 4.2388 (3.0); 4.2277 (2.9); 4.2190 (2.5); 4.2055 (2.3); 4.1960 (2.9); 4.1900 (3.0); 4.1803 (3.0); 4.1687 (1.2); 4.1621 (1.5); 4.1535 (1.0); 4.0598 (7.2); 4.0415 (16.0); 4.0233 (7.7); 3.9019 (14.4); 3.6741 (1.1); 3.6565 (1.3); 3.6395 (5.7); 3.6262 (7.3); 3.6225 (7.2); 3.6091 (5.8); 3.5923 (1.3); 3.5744 (1.1); 3.3250 (290.4); 3.1689 (0.9); 2.9789 (7.8); 2.9608 (16.0); 2.9425 (6.9); 2.6751 (1.2); 2.6707 (1.5); 2.6661 (1.2); 2.5060 (212.7); 2.5016 (264.0); 2.4971 (190.8); 2.3327 (1.2); 2.3284 (1.5); 2.3238 (1.1); 2.1018 (0.4); 2.0924 (0.8); 2.0807 (0.9); 2.0675 (1.8); 2.0577 (2.5); 2.0455 (3.2); 2.0345 (3.7); 2.0269 (4.0); 2.0184 (3.3); 2.0031 (1.8); 1.9923 (1.1); 1.9842 (0.8); 1.9771 (0.7); 1.9686 (0.4); 1.2333 (0.4); 1.2186 (0.6); 1.2122 (0.9); 1.1995 (1.9); 1.1933 (1.8); 1.1815 (3.1); 1.1696 (1.9); 1.1633 (2.0); 1.1506 (1.0); 0.4529 (2.0); 0.4378 (7.2); 0.4286 (4.4); 0.4223 (6.0); 0.4177 (6.6); 0.4089 (3.1); 0.3908 (0.6); 0.3857 (0.6); 0.3719 (0.8); 0.3474 (3.3); 0.3356 (8.1); 0.3264 (7.7); 0.3121 (2.1); 0.0001 (2.7)
[0787] I-278: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0788] =7.3366 (1.2); 7.3209 (1.4); 7.3147 (1.4); 7.1254 (1.2); 7.1200 (1.9); 7.1110 (3.6); 7.1031 (2.3); 7.0958 (1.6); 7.0827 (0.6); 7.0707 (1.7); 7.0640 (1.3); 7.0485 (0.9); 6.2653 (1.6); 6.2424 (1.6); 4.6853 (0.4); 4.6662 (0.7); 4.6546 (0.9); 4.6327 (0.4); 4.0240 (2.3); 4.0059 (5.0); 3.9877 (2.5); 3.9018 (6.6); 3.3246 (64.2); 3.1803 (16.0); 2.9457 (2.3); 2.9276 (4.7); 2.9093 (2.1); 2.7470 (0.7); 2.7282 (0.9); 2.7142 (1.1); 2.6987 (1.2); 2.6842 (0.6); 2.6711 (0.7); 2.6577 (0.4); 2.5060 (56.7); 2.5018 (71.2); 2.4976 (53.1); 2.3285 (0.4); 2.3242 (0.3); 1.9636 (0.4); 1.9571 (0.5); 1.9432 (0.8); 1.9281 (1.3); 1.9016 (0.7); 1.8827 (0.4); 1.8118 (0.3); 1.7838 (0.8); 1.7645 (0.8); 1.7594 (0.8); 1.7411 (0.5); 1.7320 (0.4); 1.7148 (0.6); 1.6932 (0.6); 1.6759 (0.4); 0.0001 (0.8)
[0789] I-281: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0790] =7.3346 (0.4); 7.3147 (11.0); 7.3039 (16.0); 7.2945 (2.7); 7.2754 (0.5); 7.2654 (1.2); 7.2557 (1.5); 7.2438 (1.6); 7.2357 (0.6); 7.2319 (0.8); 7.1257 (0.5); 7.1113 (1.4); 7.1075 (1.5); 7.0946 (3.1); 7.0891 (3.5); 7.0758 (1.4); 7.0715 (1.7); 7.0569 (2.5); 7.0383(I.I); 6.2879 (2.0); 6.2652 (2.1); 4.9416 (7.5); 4.6720 (0.5); 4.6534 (0.8); 4.6411 (0.9); 4.6199 (0.5); 4.0944 (2.7); 4.0762 (5.8); 4.0581 (2.8); 3.9015 (8.9); 3.3226 (82.2); 3.2672 (0.4); 3.1741 (0.5); 3.1629 (0.5); 3.0475 (2.8); 3.0294 (5.8); 3.0112 (2.6); 2.7555 (0.3); 2.7311 (0.7); 2.7135 (1.0); 2.7002 (1.2); 2.6840 (1.3); 2.6746 (1.0); 2.6702 (1.3); 2.6420 (0.4); 2.5233 (2.0); 2.5098 (42.4); 2.5056 (82.9); 2.5012 (107.0); 2.4967 (77.9); 2.3323 (0.5); 2.3278 (0.6); 2.3235 (0.5); 1.9381 (0.6); 1.9295 (0.9); 1.9156 (1.6); 1.9035 (1.5); 1.8885 (0.8); 1.8695 (0.5); 1.8017 (0.4); 1.7968 (0.4); 1.7743 (1.0); 1.7548 (0.8); 1.7504 (0.8); 1.7316 (0.6); 1.7179 (0.5); 1.7005 (0.6); 1.6807 (0.7); 1.6611 (0.4); 0.0002 (1.8)
[0791] 1H-NMR
[0792] I-282: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0793] =7.4788 (1.5); 7.4723 (1.1); 7.4689 (1.2); 7.4610 (1.1); 7.4558 (2.0); 7.3208 (0.5); 7.3054 (2.3); 7.2956 (3.0); 7.2878 (2.2); 7.2845 (2.6); 7.2698 (0.6); 7.2565 (1.6); 7.2380 (2.1); 7.2014 (1.3); 7.1948 (1.8); 7.1831 (3.4); 7.1707 (2.0); 7.1516 (2.0); 7.1337 (1.0); 7.1145 (1.3); 7.0974 (1.6); 7.0792 (0.6); 6.3729 (1.9); 6.3514 (2.0); 4.9857 (4.3); 4.9820 (4.4); 4.9634 (1.4); 4.9425 (1.4); 4.9236 (0.5); 4.1847 (2.3); 4.1666 (5.2); 4.1486 (2.4); 3.9017 (16.0); 3.6151 (0.4); 3.3212 (46.1); 3.1742 (0.4); 3.1622 (0.4); 3.1371 (2.5); 3.1191 (5.3); 3.1010 (2.3); 2.9204 (0.4); 2.9127 (0.4); 2.8988 (0.5); 2.8909 (0.5); 2.8817 (0.7); 2.8736 (0.7); 2.8599 (0.8); 2.8519 (0.7); 2.7670 (0.5); 2.7465 (1.1); 2.7264 (0.9); 2.7075 (0.7); 2.6863 (0.4); 2.6742 (0.4); 2.6700 (0.6); 2.6657 (0.4); 2.5231 (1.7); 2.5054 (76.6); 2.5010 (99.3); 2.4965 (72.8); 2.4548 (0.5); 2.4463 (0.5); 2.4354 (0.8); 2.4268 (0.8); 2.4159 (0.8); 2.4047 (0.9); 2.3963 (0.7); 2.3855 (0.4); 2.3772 (0.4); 2.3322 (0.4); 2.3278 (0.6); 2.3234 (0.5); 1.8069 (0.4); 1.7853 (0.9); 1.7755 (0.4); 1.7649 (0.9); 1.7544 (0.9); 1.7434 (0.4); 1.7338 (0.8); 0.0002 (1.3)
[0794] I-283: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0795] =7.1164 (4.2); 7.1008 (2.4); 7.0816 (3.3); 6.9939 (2.6); 6.9749 (1.8); 6.2468 (2.3); 6.2252 (2.4); 5.0028 (0.6); 4.9829 (1.7); 4.9628 (1.6); 4.9424 (0.6); 4.8813 (0.5); 4.8640 (1.4); 4.8466 (1.9); 4.8293 (1.4); 4.8121 (0.5); 4.0851 (0.3); 4.0302 (3.1); 4.0120 (6.8); 3.9940 (3.3); 3.9016 (5.9); 3.6003 (0.5); 3.3230 (49.2); 3.1748 (1.6); 3.1622 (1.6); 2.9181 (3.4); 2.9000 (7.0); 2.8820 (3.4); 2.8725 (0.8); 2.8642 (0.7); 2.8548 (0.9); 2.8476 (0.9); 2.8325 (0.9); 2.8260 (0.9); 2.7357 (0.6); 2.7150 (1.2); 2.6945 (1.0); 2.6752 (1.2); 2.6553 (0.5); 2.5056 (85.1); 2.5014 (107.1); 2.4971 (78.6); 2.4679 (1.2); 2.4563 (1.4); 2.4484 (1.3); 2.4371 (1.3); 2.4255 (1.3); 2.4179 (1.1); 2.4067 (0.8); 2.3986 (0.6); 2.3282 (0.7); 2.3232 (0.7); 2.3187 (0.7); 2.2531 (16.0); 1.8520 (0.5); 1.8307 (1.2); 1.8214 (0.6); 1.8096 (1.2); 1.7997 (1.2); 1.7878 (0.6); 1.7788 (1.1); 1.7570 (0.4); 1.4039 (13.1); 1.3867 (13.3); 1.3479 (0.7); 1.3326 (0.6); 1.2354 (0.4); 1.1938 (0.3); 1.1760 (0.6); 1.1587 (0.8); 1.1544 (0.6); 1.1428 (0.6); 1.1384 (0.6); 0.0002 (1.8 )
[0796] I-284: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0797] =7.1020 (5.8); 7.0810 (3.2); 6.9930 (2.6); 6.9743 (1.8); 6.3062 (2.4); 6.2844 (2.5); 5.0053 (0.6); 4.9850 (1.7); 4.9649 (1.7); 4.9452 (0.6); 4.0544 (3.0); 4.0361 (6.6); 4.0179 (3.2); 3.9018 (6.5); 3.6376 (5.0); 3.6200 (5.1); 3.6035 (0.6); 3.3228 (97.4); 3.1748 (0.7); 3.1620 (0.6); 2.9789 (3.3); 2.9607 (6.9); 2.9425 (3.0); 2.8888 (0.5); 2.8819 (0.6); 2.8671 (0.6); 2.8596 (0.6); 2.8494 (0.9); 2.8428 (1.0); 2.8275 (0.9); 2.8214 (0.9); 2.7345 (0.6); 2.7135 (1.3); 2.6933 (1.0); 2.6746 (1.3); 2.6536 (0.5); 2.5057 (88.2); 2.5014 (110.4); 2.4970 (81.4); 2.4656 (0.8); 2.4539 (1.0); 2.4465 (1.0); 2.4351 (1.1); 2.4232 (1.0); 2.4159 (0.9); 2.4045 (0.6); 2.3968 (0.4); 2.3326 (0.6); 2.3282 (0.7); 2.3236 (0.5); 2.2515 (16.0); 1.8438 (0.4); 1.8221 (1.2); 1.8128 (0.5); 1.8009 (1.2); 1.7913 (1.2); 1.7792 (0.5); 1.7700 (1.1); 1.7485 (0.4); 1.2214 (0.4); 1.2104 (0.8); 1.2026 (0.8); 1.1910 (1.2); 1.1789 (0.9); 1.1723 (0.9); 1.1592 (0.5); 0.4559 (0.8); 0.4402 (3.2); 0.4306 (1.9); 0.4243 (2.6); 0.4203 (3.0); 0.4109 (1.3); 0.3760 (0.4); 0.3528 (1.3); 0.3405 (3.7); 0.3315 (3.3); 0.3281 (3.2); 0.3159 (0.8); 0.0001 (1.4)
[0798] I-285: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0799] =7.6471 (0.4); 7.6413 (0.4); 7.3975 (0.5); 7.3736 (0.4); 7.3564 (0.6); 7.3317 (1.1); 7.3180 (12.2); 7.3071 (15.2); 7.2884 (0.9); 7.2778 (0.7); 7.2682 (1.5); 7.2582 (2.0); 7.2471 (1.8); 7.2372 (1.0); 7.2253 (0.5); 7.1988 (0.5); 7.1819 (0.4); 7.0883 (2.4); 7.0691 (7.6); 6.9828 (2.5); 6.9632 (1.8); 6.3115 (2.4); 6.2897 (2.5); 5.7337 (0.5); 5.7278 (0.5); 5.1455 (1.1); 5.0880 (1.1); 4.9888 (0.7); 4.9695 (1.8); 4.9473 (10.2); 4.9298 (0.9); 4.1052 (3.0); 4.0870 (6.8); 4.0690 (3.2); 3.9015 (8.1); 3.5991 (0.5); 3.5899 (0.4); 3.3243 (135.6); 3.2672 (0.6); 3.1750 (1.6); 3.1620 (1.5); 3.0527 (3.2); 3.0346 (6.8); 3.0165 (3.0); 2.8772 (0.5); 2.8699 (0.6); 2.8554 (0.6); 2.8473 (0.7); 2.8383 (0.9); 2.8311 (1.0); 2.8165 (0.9); 2.8095 (0.9); 2.7211 (0.6); 2.6999 (1.2); 2.6796 (1.2); 2.6701 (1.0); 2.6652 (1.1); 2.6406 (0.5); 2.5055 (103.3); 2.5011 (130.1); 2.4966 (96.0); 2.4567 (0.9); 2.4492 (0.9); 2.4377 (1.1); 2.4299 (1.2); 2.4186 (1.2); 2.4071 (1.2); 2.3992 (1.0); 2.3880 (0.7); 2.3800 (0.6); 2.3320 (0.9); 2.3281 (1.0); 2.2328 (16.0); 1.8249 (0.5); 1.8033 (1.2); 1.7939 (0.6); 1.7824 (1.2); 1.7726 (1.2); 1.7607 (0.6); 1.7515 (1.1); 1.7299 (0.4); 0.0002 (1.5)
[0800] 1H-NMR
[0801] I-286: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0802] =11.1441 (2.8); 7.6503 (0.5); 7.6305 (0.4); 7.2974 (1.5); 7.2800 (1.9); 7.2269 (1.2); 7.2092 (2.2); 7.1946 (0.9); 7.1915 (1.0); 7.1765 (1.9); 7.1590 (2.4); 7.1545 (2.1); 7.1400 (1.4); 7.1224 (0.5); 6.1936 (1.1); 6.1712 (1.2); 5.0348 (0.4); 5.0150 (I.I); 4.9950(I.I); 4.9749 (0.4); 4.0188 (2.4); 4.0007 (5.3); 3.9826 (2.6); 3.9262 (0.4); 3.9018 (16.0); 3.3280 (95.1); 3.2672 (0.3); 3.1684 (2.5); 3.1093 (0.4); 2.9490 (0.4); 2.9406 (0.5); 2.9275 (0.5); 2.9193 (0.6); 2.9097 (0.7); 2.9019 (0.8); 2.8874 (0.8); 2.8801 (0.8); 2.8414 (2.9); 2.8233 (6.2); 2.8051 (2.8); 2.7897 (0.7); 2.7794 (0.7); 2.7689 (1.2); 2.7486 (0.9); 2.7293 (0.7); 2.7089 (0.4); 2.6751 (0.4); 2.6707 (0.6); 2.6663 (0.5); 2.6463 (0.4); 2.6313 (0.4); 2.6169 (0.4); 2.5238 (1.6); 2.5104 (40.5); 2.5062 (81.4); 2.5017 (107.0); 2.4972 (79.6); 2.4929 (41.2); 2.4721 (1.2); 2.4635 (0.9); 2.4525 (1.0); 2.4441 (1.0); 2.4330 (1.0); 2.4212 (1.0); 2.4136 (0.9); 2.4023 (0.5); 2.3942 (0.5); 2.3330 (0.5); 2.3284 (0.7); 2.3239 (0.5); 1.8591 (0.4); 1.8375 (1.0); 1.8282 (0.4); 1.8169 (1.0); 1.8065 (1.0); 1.7953 (0.4): 1.7860 (0.9); 1.7644 (0.3); 0.0002 (0.5)
[0803] I-287: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0804] =11.1322 (4.6); 7.3336 (1.9); 7.3186 (2.1); 7.3116 (2.2); 7.1380 (0.5); 7.1250 (2.1); 7.1206 (3.4); 7.1117 (5.8); 7.1031 (4.3); 7.0977 (2.7); 7.0851 (1.0); 7.0797 (0.8); 7.0697 (2.6); 7.0621 (2.0); 7.0475 (1.4); 6.1338 (2.5); 6.1108 (2.6); 4.6731 (0.6); 4.6626 (0.8); 4.6548 (1.0); 4.6429 (1.2); 4.6218 (0.6); 4.0077 (3.5); 3.9895 (7.7); 3.9714 (3.7); 3.9019 (16.0); 3.6003 (2.4); 3.3211 (49.7); 2.8363 (3.9); 2.8182 (8.1); 2.8000 (3.6); 2.7863 (0.4); 2.7701 (0.5); 2.7435 (1.0); 2.7260 (1.5); 2.7117 (1.6); 2.6939 (1.9); 2.6800 (1.5); 2.6703 (1.2); 2.6658 (1.1); 2.6519 (0.6); 2.5402 (0.4); 2.5231 (2.2); 2.5056 (86.8); 2.5012 (112.7); 2.4968 (83.3); 2.3322 (0.5); 2.3279 (0.6); 2.3236 (0.5); 1.9295 (1.5); 1.9161 (2.0); 1.9066 (2.4); 1.8930 (1.4); 1.8075 (0.5); 1.8038 (0.5); 1.7804 (1.2); 1.7616 (1.2); 1.7385 (0.8); 1.7220 (0.7); 1.7033 (0.8); 1.6976 (0.8); 1.6844 (1.0); 1.6648 (0.7);-0.0001 (1.4)
[0805] I-290: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0806] =11.1576 (2.6); 7.2822 (1.4); 7.2651 (1.5); 7.1387 (0.6); 7.1349 (0.6); 7.1175 (1.4); 7.0998 (0.9); 7.0964 (0.9); 6.8589 (0.9); 6.8566 (1.0); 6.8400 (1.6); 6.8385 (1.6); 6.8217 (0.8); 6.8193 (0.8); 6.7557 (1.8); 6.7351 (1.8); 6.3576 (1.4); 6.3358 (1.5); 4.7009 (0.4); 4.6875 (0.8); 4.6763 (0.6); 4.6660 (0.8); 4.6528 (0.4); 4.2573 (0.4); 4.2468 (0.4); 4.2385 (0.9); 4.2292 (0.8); 4.2201 (0.7); 4.2104 (0.7); 4.1966 (0.6); 4.1825 (0.9); 4.1712 (0.8); 4.1541 (0.4); 4.0214 (1.9); 4.0033 (4.2); 3.9852 (2.0); 3.9020 (16.0); 3.6027 (1.2); 3.3227 (47.5); 2.8405 (2.0); 2.8224 (4.3); 2.8043 (1.9); 2.6748 (0.4); 2.6704 (0.5); 2.5405 (0.3); 2.5058 (55.7); 2.5014 (71.4); 2.4969 (52.0); 2.3282 (0.4); 2.0462 (0.5); 2.0333 (0.9); 2.0171 (1.4); 2.0071 (1.2); 1.9937 (0.5); 1.9826 (0.3); 0.0002 (0.9)
[0807] I-291: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0808] =7.3072 (1.5); 7.2898 (1.8); 7.2171 (1.1); 7.2000 (2.2); 7.1817 (1.0); 7.1668 (1.9); 7.1493 (2.3); 7.1456 (2.1); 7.1301 (1.4); 7.1118 (0.5); 6.2892 (1.7); 6.2675 (1.7); 5.0487 (0.5); 5.0287 (1.3); 5.0086 (1.3); 4.9881 (0.4); 3.9549 (1.9); 3.9395 (4.1); 3.9241 (2.1); 3.9019 (16.0); 3.8753 (1.0); 3.8617 (2.0); 3.8421 (2.0); 3.8281 (1.0); 3.8083 (0.5); 3.5880 (0.4); 3.5765 (0.8); 3.5695 (0.8); 3.5586 (1.2); 3.5456 (0.8); 3.5384 (0.7); 3.5260 (0.4); 3.3215 (50.9); 3.1703 (0.4); 2.9520 (0.4); 2.9447 (0.5); 2.9304 (0.5); 2.9221 (0.5); 2.9125 (0.7); 2.9049 (0.8); 2.8907 (0.8); 2.8835 (0.7); 2.7937 (0.5); 2.7729 (1.1); 2.7524 (0.9); 2.7337 (0.7); 2.7129 (0.4); 2.6706 (0.6); 2.5396 (0.5); 2.5057 (87.1); 2.5015 (110.1); 2.4975 (82.1); 2.4688 (0.8); 2.4571 (0.8); 2.4489 (0.9); 2.4376 (0.9); 2.4262 (0.9); 2.4183 (0.8); 2.4068 (0.4); 2.3990 (0.4); 2.3284 (0.7); 2.3240 (0.6); 2.1049 (0.5); 2.0911 (1.8); 2.0763 (2.6); 2.0614 (1.8); 2.0470 (0.6); 1.8893 (0.4); 1.8677 (0.9); 1.8587 (0.4); 1.8470 (1.0); 1.8369 (0.9); 1.8257 (0.4); 1.8159 (0.9); 0.9064 (0.5); 0.8943 (1.8); 0.8866 (3.1); 0.8830 (3.0); 0.8758 (2.8); 0.8701 (1.9); 0.8530 (2.9); 0.8458 (1.6); 0.8392 (1.9); 0.8332 (2.7); 0.8265 (1.5); 0.8143 (0.8); 0.0002 (0.9)
[0809] 1H-NMR
[0810] I-292: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0811] =7.8290 (1.6); 7.8030 (1.4); 7.7816 (0.9); 7.6254 (0.6); 7.6060 (1.0); 7.5870 (0.4); 7.0841 (1.2); 7.0667 (0.7); 7.0372 (0.8); 7.0183 (1.2); 6.9807 (0.6); 6.9607 (0.4); 6.9461 (1.0); 6.9260 (0.6); 6.8993 (1.5); 5.9259 (0.9); 5.9042 (0.9); 4.9171 (0.3); 4.6224 (0.6); 4.6029 (0.6); 3.9974 (0.4); 3.9872 (0.4); 3.9737 (0.9); 3.9595 (1.3); 3.9459 (0.7); 3.9067 (2.9); 3.9020 (16.0); 3.8859 (0.5); 3.7744 (0.6); 3.7598 (1.1); 3.7451 (0.6); 3.3220 (34.8); 3.1871 (0.6); 3.1738 (0.6); 2.7297 (0.3); 2.7143 (0.3); 2.7074 (0.4); 2.6793 (0.4); 2.6746 (0.5); 2.6705 (0.6); 2.6654 (0.6); 2.5589 (0.5); 2.5400 (0.7); 2.5057 (74.2); 2.5013 (97.0); 2.4970 (72.8); 2.4084 (0.3); 2.3852 (0.3); 2.3764 (0.4); 2.3670 (0.5); 2.3278 (1.0); 2.3231 (0.9); 2.3116 (0.7); 2.2955 (0.8); 2.2861 (0.5); 2.2531 (3.6); 2.2220 (5.9); 2.1494 (0.3); 2.1421 (0.4); 2.1303 (0.4); 2.1184 (0.4); 2.1114 (0.4); 1.9743 (0.4); 1.9593 (0.6); 1.9461 (0.4); 1.6110 (0.4); 1.5898 (0.4); 1.5798 (0.4); 1.5592 (0.4); 0.0002 (0.8)
[0812] I-293: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0813] =7.8338 (2.8); 7.8231 (1.7); 7.8038 (3.0); 7.7854 (1.6); 7.6245 (1.3); 7.6052 (2.0); 7.5858 (0.9); 7.1624 (0.7); 7.1432 (3.3); 7.1352 (1.4); 7.1294 (1.1); 7.1223 (1.5); 7.1118 (0.5); 7.1037 (0.7); 7.0913 (0.4); 7.0717 (2.0); 7.0668 (3.2); 7.0590 (3.4); 7.0564 (3.2); 5.9819 (1.8); 5.9603 (1.8); 4.6768 (0.5); 4.6571 (1.4); 4.6371 (1.3); 4.6171 (0.5); 3.9912 (0.6); 3.9773 (2.2); 3.9623 (4.4); 3.9464 (2.4); 3.9255 (1.2); 3.9019 (16.0); 3.8919 (0.7); 3.8769 (0.3); 3.3231 (69.1); 2.8412 (0.4); 2.8333 (0.5); 2.8195 (0.5); 2.8114 (0.5); 2.8022 (0.7); 2.7938 (0.7); 2.7805 (0.7); 2.7723 (0.7); 2.6747 (0.5); 2.6704 (0.7); 2.6659 (0.5); 2.6452 (0.5); 2.6240 (1.1); 2.6042 (0.9); 2.5848 (0.8); 2.5644 (0.4); 2.5403 (0.3); 2.5236 (2.1); 2.5101 (49.3); 2.5059 (97.9); 2.5015 (127.4); 2.4970 (93.1); 2.3329 (1.0); 2.3279 (1.3); 2.3227 (1.7); 2.3059 (1.9); 2.2912 (1.3); 2.1887 (0.4); 2.1807 (0.4); 2.1695 (0.6); 2.1612 (0.7); 2.1502 (0.8); 2.1387 (0.8); 2.1306 (0.7); 2.1198 (0.4); 2.1114 (0.4); 1.6661 (0.4); 1.6449 (0.9); 1.6350 (0.4); 1.6243 (0.9); 1.6138 (0.9); 1.6027 (0.4); 1.5933 (0.8); 0.0002 (1.5)
[0814] I-295: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0815] =7.4836 (0.4); 7.4778 (0.4); 7.1005 (2.7); 7.0913 (1.7); 7.0721 (2.2); 6.9851 (1.6); 6.9664 (1.2); 6.2413 (1.5); 6.2196 (1.5); 5.0094 (0.4); 4.9896 (1.1); 4.9693 (1.0); 4.9496 (0.4); 3.9537 (1.7); 3.9383 (3.7); 3.9228 (1.9); 3.9018 (16.0); 3.8749 (1.0); 3.8610 (2.2); 3.8449 (2.2); 3.8308 (1.0); 3.8114 (0.5); 3.5898 (0.6); 3.5821 (0.7); 3.5707 (1.2); 3.5588 (0.8); 3.5510 (0.7); 3.5388 (0.4); 3.3216 (49.2); 3.1683 (1.4); 2.8798 (0.4); 2.8652 (0.4); 2.8575 (0.4); 2.8482 (0.5); 2.8407 (0.6); 2.8262 (0.6); 2.8198 (0.5); 2.7299 (0.4); 2.7092 (0.8); 2.6894 (0.6); 2.6703 (1.1); 2.5405 (0.3); 2.5233 (1.9); 2.5057 (86.4); 2.5013 (112.7); 2.4968 (82.9); 2.4655 (0.8); 2.4578 (0.7); 2.4460 (0.8); 2.4386 (0.8); 2.4272 (0.9); 2.4156 (0.8); 2.4078 (0.8); 2.3962 (0.8); 2.3880 (0.5); 2.3670 (1.4); 2.3324 (0.6); 2.3280 (0.8); 2.3236 (0.6); 2.2699 (0.4); 2.2491 (10.6); 2.1058 (0.5); 2.0911 (1.6); 2.0766 (2.3); 2.0620 (1.7); 2.0474 (0.6); 1.8385 (0.8); 1.8292 (0.4); 1.8177 (0.8); 1.8078 (0.8); 1.7961 (0.4); 1.7867 (0.7); 0.9109 (0.6); 0.8987 (1.8); 0.8914 (2.8); 0.8873 (2.8); 0.8801 (2.5); 0.8740 (1.9); 0.8569 (2.6); 0.8497 (1.6); 0.8436 (1.9); 0.8371 (2.6); 0.8298 (1.4); 0.8184 (0.7); 0.0002 (1.2)
[0816] I-297: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0817] =7.8238 (2.5); 7.8203 (2.4); 7.7978 (2.3); 7.6326 (1.0); 7.6136 (1.5); 7.5941 (0.7); 7.0889 (0.6); 7.0853 (0.7); 7.0673 (1.3); 7.0470 (2.0); 7.0292 (1.5); 6.7862 (0.9); 6.7836 (1.0); 6.7654 (1.6); 6.7491 (0.7); 6.7465 (0.8); 6.6907 (1.7); 6.6702 (1.6); 6.1290 (1.5); 6.1075 (1.6); 4.2945 (0.4); 4.2812 (0.8); 4.2681 (0.6); 4.2602 (0.8); 4.2458 (0.4); 4.1405 (0.4); 4.1295 (0.5); 4.1241 (0.4); 4.1129 (0.9); 4.0997 (0.9); 4.0850 (0.5); 4.0540 (0.3); 4.0381 (0.5); 4.0121 (0.8); 4.0048 (1.7); 3.9918 (1.0); 3.9744 (1.5); 3.9595 (2.0); 3.9447 (0.9); 3.9394 (0.9); 3.9020 (16.0); 3.8914 (0.6); 3.8817 (0.6); 3.8718 (0.5); 3.8610 (0.7); 3.8487 (0.4); 3.8408 (0.4); 3.8301 (0.3); 3.7579 (0.4); 3.3207 (40.3); 3.1745 (0.4); 2.6750 (0.4); 2.6704 (0.6); 2.6657 (0.4); 2.5236 (1.8); 2.5101 (38.4); 2.5058 (77.3); 2.5013 (101.1); 2.4968 (73.5); 2.4926 (36.4); 2.3279 (1.1); 2.3236 (1.1); 2.3103 (1.0); 2.2960 (1.0); 2.2846 (0.7); 1.7300 (0.7); 1.7157 (1.7); 1.7027 (1.7); 1.6901 (0.7); 0.0002 (1.7)
[0818] 1H-NMR
[0819] I-298: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0820] =7.2930 (2.1); 7.2738 (2.2); 7.1260 (1.0); 7.1224 (1.1); 7.1048 (2.1); 7.0875 (1.3); 7.0839 (1.3); 6.8464 (1.5); 6.8440 (1.6); 6.8256 (2.8); 6.8094 (1.3); 6.8068 (1.3); 6.7427 (2.9); 6.7409 (2.9); 6.7224 (2.7); 6.4224 (2.5); 6.4008 (2.6); 4.7278 (0.6); 4.7140 (1.3); 4.7007 (0.9); 4.6926 (1.3); 4.6790 (0.6); 4.2766 (0.5); 4.2667 (0.7); 4.2583 (0.6); 4.2487 (1.4); 4.2379 (1.3); 4.2318 (1.2); 4.2206 (1.0); 4.2004 (0.9); 4.1874 (1.5); 4.1749 (1.3); 4.1630 (0.6); 4.1577 (0.7); 4.1479 (0.5); 3.9571 (2.4); 3.9417 (5.2); 3.9262 (2.4); 3.9019 (16.0); 3.8762 (1.2); 3.8624 (2.2); 3.8495 (1.6); 3.8373 (2.2); 3.8231 (1.2); 3.8041 (0.7); 3.7904 (0.4); 3.5800 (0.4); 3.5678 (0.9); 3.5605 (1.0); 3.5493 (1.6); 3.5365 (1.0); 3.5292 (1.0); 3.5171 (0.4); 3.3216 (68.8); 3.1746 (1.2); 3.1621 (1.1); 2.6745 (0.5); 2.6703 (0.7); 2.6659 (0.5); 2.5402 (0.3); 2.5235 (2.1); 2.5099 (46.5); 2.5058 (91.4); 2.5013 (118.4); 2.4969 (87.1); 2.3327 (0.5); 2.3280 (0.7); 2.3237 (0.5); 2.1061 (0.7); 2.0916 (2.3); 2.0770 (3.4); 2.0620 (2.8); 2.0433 (2.8); 2.0331 (2.2); 2.0188 (0.9); 2.0086 (0.4); 1.2117 (0.4); 1.1956 (0.3); 0.9102 (0.5); 0.8976 (2.0); 0.8903 (4.0); 0.8860 (3.6); 0.8787 (3.6); 0.8671 (2.2); 0.8620 (3.9); 0.8543 (1.9); 0.8482 (2.0); 0.8422 (3.7); 0.8346 (1.8); 0.8224 (0.6): -0.0002 (1.7)
[0821] I-301: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0822] =7.4830 (0.6); 7.4775 (0.7); 7.4381 (0.5); 7.1112 (1.9); 7.0960 (1.1); 7.0770 (1.6); 6.9882 (1.2); 6.9697 (0.8); 6.2939 (0.5); 6.2726 (0.5); 4.9758 (0.6); 4.9562 (0.6); 3.9104 (1.3); 3.9019 (16.0); 3.8957 (3.0); 3.8803 (1.4); 3.8371 (0.4); 3.8218 (0.7); 3.8103 (1.4); 3.7968 (1.6); 3.7831 (1.4); 3.7607 (0.4); 3.7469 (0.3); 3.4203 (0.6); 3.4093 (11.9); 3.3908 (0.8); 3.3785 (2.8); 3.3307 (14.0); 3.1682 (3.9); 3.0616 (0.4); 3.0482 (0.4); 3.0336 (0.4); 2.8518 (0.4); 2.8446 (0.4); 2.8300 (0.4); 2.8235 (0.4); 2.7086 (0.6); 2.6882 (0.4); 2.6704 (0.8); 2.6316 (0.6); 2.6170 (0.5); 2.6026 (0.5); 2.5236 (1.2); 2.5101 (33.2); 2.5059 (66.8); 2.5014 (87.1); 2.4969 (63.8); 2.4655 (0.6); 2.4573 (0.5); 2.4460 (0.6); 2.4379 (0.6); 2.4266 (0.6); 2.4153 (0.6); 2.4073 (0.6); 2.3966 (0.4); 2.3884 (0.4); 2.3672 (2.4); 2.3326 (0.5); 2.3281 (0.6); 2.3236 (0.5); 2.2503 (7.6); 2.1857 (0.4); 2.1716 (1.0); 2.1574 (1.3); 2.1438 (1.1); 2.1308 (0.6); 2.1175 (0.4); 1.8178 (0.6); 1.7969 (0.6); 1.7868 (0.6); 1.7660 (0.5); 0.0002 (1.0)
[0823] I-302: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0824] =7.3123 (1.9); 7.2943 (2.4); 7.2227 (1.3); 7.2050 (2.8); 7.1855 (1.2); 7.1702 (2.4); 7.1488 (2.6); 7.1299 (1.9); 7.1120 (0.7); 6.3415 (2.4); 6.3198 (2.5); 5.0350 (0.6); 5.0149 (1.7); 4.9948 (1.7); 4.9748 (0.6); 3.9108 (2.5); 3.9014 (16.0); 3.8964 (5.7); 3.8806 (2.4); 3.8086 (2.4); 3.7951 (3.0); 3.7815 (2.5); 3.4018 (21.8); 3.3224 (82.1); 3.1737 (0.6); 3.1610 (0.6); 2.9542 (0.5); 2.9466 (0.6); 2.9326 (0.6); 2.9245 (0.6); 2.9153 (0.9); 2.9071 (0.9); 2.8935 (0.9); 2.8857 (0.9); 2.7924 (0.7); 2.7721 (1.4); 2.7519 (1.1); 2.7324 (0.9); 2.7114 (0.5); 2.6697 (0.6); 2.6652 (0.5); 2.5394 (0.4); 2.5048 (81.2); 2.5007 (103.0); 2.4965 (76.6); 2.4697 (0.8); 2.4587 (1.0); 2.4502 (1.0); 2.4391 (1.0); 2.4278 (1.0); 2.4197 (0.9); 2.4086 (0.5); 2.4006 (0.4); 2.3315 (0.5); 2.3274 (0.6); 2.1852 (0.6); 2.1707 (1.9); 2.1570 (2.4); 2.1432 (1.8); 2.1282 (0.6); 1.8632 (0.4); 1.8417 (1.2); 1.8320 (0.5); 1.8207 (1.2); 1.8108 (1.2); 1.7994 (0.5): I 7899 (1.1); 1.7684 (0.4); 0.0003 (0.9)
[0825] I-304: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0826] =7.2897 (1.7); 7.2708 (1.8); 7.1307 (0.8); 7.1271 (0.8); 7.1095 (1.7); 7.0923 (1.1); 7.0886 (1.0); 6.8468 (1.2); 6.8446 (1.2); 6.8262 (2.1); 6.8098 (1.0); 6.8074 (1.0); 6.7472 (2.4); 6.7269 (2.2); 6.4740 (1.8); 6.4523 (1.9); 4.7143 (0.5); 4.7003 (1.0); 4.6885 (0.8); 4.6791 (1.0); 4.6656 (0.5); 4.2763 (0.4); 4.2678 (0.5); 4.2563 (0.5); 4.2485 (1.2); 4.2400 (1.0); 4.2291 (0.9); 4.2202 (0.8); 4.2017 (0.7); 4.1925 (0.9); 4.1866 (1.0); 4.1764 (1.0); 4.1653 (0.4); 4.1586 (0.5); 4.1498 (0.4); 3.9148 (1.9); 3.9017 (16.0); 3.8846 (2.0); 3.8087 (1.9); 3.7952 (2.5); 3.7814 (2.0); 3.4068 (18.7); 3.3220 (54.6); 3.1684 (2.5); 2.6745 (0.4); 2.6700 (0.6); 2.5398 (0.4); 2.5231 (2.0); 2.5055 (83.7); 2.5011 (107.9); 2.4967 (78.8); 2.3324 (0.5); 2.3278 (0.6); 2.1858 (0.5); 2.1712 (1.5); 2.1573 (1.9); 2.1434 (1.4); 2.1283 (0.5); 2.0606 (0.6); 2.0510 (0.8); 2.0389 (1.1); 2.0278 (1.3); 2.0206 (1.3); 2.0125 (1.1); 1.9975 (0.6); 1.9865 (0.4); 0.0002 (1.1)
[0827] 1H-NMR
[0828] I-305: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0829] =7.8705 (0.5); 7.8506 (0.5); 7.5420 (0.5); 7.5264 (0.3); 7.5230 (0.3); 7.3628 (1.0); 7.3439 (1.1); 7.3358 (0.9); 7.3200 (1.0); 7.3137 (1.0); 7.1185 (0.9); 7.1128 (1.2); 7.1038 (2.6); 7.0961 (1.5); 7.0885 (1.1); 7.0757 (0.5); 7.0641 (1.2); 7.0573 (0.9); 7.0421 (0.6); 6.2637 (1.0); 6.2408 (1.0); 4.6580 (0.5); 4.6467 (0.6); 3.9020 (16.0); 3.8853 (2.8); 3.8702 (1.3); 3.8368 (0.4); 3.8215 (0.8); 3.8054 (1.6); 3.7916 (1.8); 3.7777 (1.5); 3.7602 (0.5); 3.7459 (0.4); 3.4205 (0.5); 3.4045 (12.5); 3.3782 (3.2); 3.3216 (28.7); 3.1683 (3.1); 2.9612 (0.5); 2.9461 (0.9); 2.9308 (0.6); 2.7431 (0.4); 2.7249 (0.6); 2.7108 (0.7); 2.6929 (0.8); 2.6790 (0.6); 2.6752 (0.6); 2.6702 (0.7); 2.6658 (0.6); 2.6156 (0.7); 2.6001 (0.9); 2.5831 (0.8); 2.5404 (0.3); 2.5234 (1.6); 2.5099 (38.0); 2.5056 (76.7); 2.5012 (100.7); 2.4967 (74.1); 2.4925 (37.4); 2.3323 (0.5); 2.3278 (0.6); 2.3236 (0.5); 2.1804 (0.4); 2.1657 (1.1); 2.1518 (1.4); 2.1381 (1.1); 2.1225 (0.6); 2.0573 (0.6); 2.0421 (0.8); 2.0263 (0.5); 1.9435 (0.6); 1.9291 (1.0); 1.9181 (1.0); 1.9042 (0.5); 1.7864 (0.6); 1.7671 (0.5); 1.7437 (0.4); 1.7294 (0.3); 1.7108 (0.4); 1.7061 (0.4); 1.6956 (0.4); 0.0002 (0.9)
[0830] I-306: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0831] =7.3072 (1.5); 7.2881 (1.6); 7.1439 (0.7); 7.1401 (0.7); 7.1226 (1.5); 7.1055 (0.9); 7.1017 (0.9); 6.8611 (1.0); 6.8586 (1.1); 6.8422 (1.8); 6.8403 (1.9); 6.8240 (0.9); 6.8213 (0.9); 6.7639 (2.1); 6.7435 (1.9); 6.4038 (1.7); 6.3822 (1.8); 4.7566 (0.4); 4.7432 (0.9); 4.7328 (0.7); 4.7217 (0.9); 4.7087 (0.4); 4.2935 (0.3); 4.2818 (0.5); 4.2761 (0.4); 4.2653 (1.0); 4.2523 (1.1); 4.2371 (0.6); 4.2013 (0.6); 4.1895 (1.2); 4.1762 (0.8); 4.1607 (0.6); 4.1500 (0.3); 3.9221 (1.7); 3.9020 (16.0); 3.8916 (1.9); 3.8793 (0.6); 3.8721 (0.5); 3.8517 (1.0); 3.8441 (0.8); 3.8255 (1.6); 3.8174 (2.0); 3.8113 (1.7); 3.8027 (1.3); 3.3220 (57.9); 2.6750 (0.4); 2.6705 (0.5); 2.6659 (0.4); 2.5237 (1.5); 2.5100 (37.1); 2.5059 (73.6); 2.5015 (95.7); 2.4970 (70.0); 2.3328 (0.4); 2.3283 (0.6); 2.3238 (0.4); 2.0787 (0.6); 2.0538 (3.2); 2.0415 (3.1); 1.8331 (1.2); 1.8059 (1.6); 1.7021 (1.3); 1.6742 (1.3); 1.6252 (0.8); 1.5984 (0.6); 1.3399 (0.6); 1.3121 (1.0); 1.2862 (1.5); 1.2606 (1.4); 1.2308 (1.1); 1.2247 (1.0); 1.1958 (1.0); 1.1710 (0.6); 1.1411 (0.4); 0.0002 (1.3)
[0832] I-307: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0833] =7.3225 (2.2); 7.3043 (2.7); 7.2340 (1.5); 7.2161 (3.2); 7.1960 (1.4); 7.1801 (2.7); 7.1584 (2.6); 7.1388 (2.2); 7.1210 (0.8); 6.2287 (2.4); 6.2068 (2.5); 5.0887 (0.6); 5.0687 (1.8); 5.0479 (1.8); 5.0285 (0.6); 3.9245 (2.7); 3.9090 (5.9); 3.9019 (16.0); 3.8938 (3.5); 3.8716 (1.1); 3.8649 (1.6); 3.8575 (1.4); 3.8378 (2.1); 3.8255 (3.6); 3.8108 (3.4); 3.7982 (1.4); 3.7783 (0.5); 3.3213 (41.1); 2.9759 (0.6); 2.9674 (0.7); 2.9543 (0.7); 2.9458 (0.7); 2.9364 (1.0); 2.9278 (1.0); 2.9151 (1.0); 2.9065 (1.0); 2.7968 (0.7); 2.7765 (1.5); 2.7560 (1.3); 2.7367 (1.0); 2.7165 (0.6); 2.6706 (0.7); 2.5057 (101.3); 2.5016 (125.7); 2.4979 (91.8); 2.4647 (1.2); 2.4551 (1.3); 2.4444 (1.1); 2.4338 (1.2); 2.4250 (1.0); 2.4141 (0.6); 2.4054 (0.5); 2.3322 (0.6); 2.3281 (0.8); 2.0811 (0.7); 2.0667 (2.3); 2.0522 (3.3); 2.0377 (2.2); 2.0234 (0.7); 1.9083 (0.5); 1.8869 (1.3); 1.8771 (0.6); 1.8667 (1.4); 1.8559 (1.4); 1.8353 (2.9); 1.8134 (1.7); 1.8040 (2.2); 1.6699 (1.8); 1.6078 (1.2); 1.5844 (1.0); 1.3540 (0.6); 1.3261 (1.7); 1.2970 (2.0); 1.2664 (1.8); 1.2356 (1.9); 1.2036 (2.1); 1.1809 (2.0); 1.1631 (1.0); 1.1321 (0.5); 0.0002 (1.9)
[0834] I-308: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0835] =7.1168 (3.1); 7.1069 (1.9); 7.0876 (2.5); 6.9995 (1.9); 6.9804 (1.3); 6.1856 (1.9); 6.1639 (2.0); 5.0502 (0.5); 5.0305 (1.3); 5.0104 (1.3); 4.9908 (0.4); 3.9230 (1.9); 3.9076 (4.7); 3.9020 (16.0); 3.8925 (2.4); 3.8809 (0.8); 3.8731 (1.3); 3.8650 (0.8); 3.8605 (0.7); 3.8538 (0.5); 3.8409 (1.2); 3.8270 (2.2); 3.8099 (2.2); 3.7958 (1.0); 3.7765 (0.4); 3.3218 (70.2); 2.9106 (0.4); 2.9033 (0.4); 2.8899 (0.4); 2.8817 (0.5); 2.8722 (0.6); 2.8643 (0.6); 2.8508 (0.6); 2.8433 (0.6); 2.7327 (0.4); 2.7122 (0.9); 2.6921 (0.7); 2.6742 (1.0); 2.6708 (I.I); 2.6528 (0.4); 2.5237 (1.6); 2.5102 (38.6); 2.5059 (78.2); 2.5014 (102.8); 2.4969 (75.2); 2.4926 (37.5); 2.4724 (0.9); 2.4637 (0.7); 2.4528 (0.9); 2.4441 (0.8); 2.4330 (0.9); 2.4218 (0.9); 2.4135 (0.8); 2.4028 (0.5); 2.3944 (0.4); 2.3326 (0.5); 2.3282 (0.6); 2.3236 (0.5); 2.2543 (12.5); 2.0815 (0.5); 2.0671 (1.7); 2.0525 (2.5); 2.0377 (1.7); 2.0228 (0.5); 1.8790 (0.4); 1.8575 (1.2); 1.8471 (1.1); 1.8373 (2.0); 1.8267 (1.9); 1.8157 (1.5); 1.8065 (2.1); 1.7855 (0.5); 1.6700 (1.3); 1.6069 (0.8); 1.5838 (0.7); 1.3606 (0.4); 1.3527 (0.4); 1.3301 (1.2); 1.3010 (1.3); 1.2689 (1.2); 1.2360 (1.3); 1.2051 (1.4); 1.1830 (1.4); 1.1655 (0.7); 1.1357 (0.4); 0.0002 (1.5)
[0836] 1H-NMR
[0837] I-310: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0838] =7.7103 (2.0); 7.6369 (1.2); 7.6184 (2.4); 7.5798 (1.3); 7.5606 (1.1); 7.5419 (0.5); 7.1044 (2.0); 6.9308 (4.7); 6.2396 (1.2); 6.2169 (1.3); 5.2761 (0.6); 5.0655 (0.4); 5.0272 (2.2); 5.0154 (2.1); 4.9765 (0.4); 4.6249 (0.5); 4.6131 (0.6); 4.1000 (1.6); 4.0819 (3.3); 4.0639 (1.5); 3.9018 (16.0); 3.3245 (89.5); 3.0635 (1.6); 3.0455 (3.4); 3.0274 (1.5); 2.6755 (0.7); 2.6708 (0.8); 2.6661 (0.8); 2.6617 (0.8); 2.6460 (0.7); 2.6308 (0.7); 2.5239 (1.5); 2.5062 (71.3); 2.5018 (92.2); 2.4974 (67.8); 2.3329 (0.4); 2.3283 (0.6); 2.3190 (1.1); 2.1909 (8.3); 1.9223 (0.3); 1.9043 (0.5); 1.8893 (0.9); 1.8613 (0.5); 1.7453 (0.6); 1.7205 (0.5); 1.7028 (0.4); 1.6683 (0.4); 1.6474 (0.4); 0.0002 (0.9)
[0839] I-311: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0840] =7.4809 (1.3); 7.4744 (1.0); 7.4712 (1.0); 7.4631 (1.0); 7.4580 (1.7); 7.3216 (0.4); 7.3063 (2.1); 7.2965 (2.6); 7.2856 (2.3); 7.2706 (0.5); 7.2005 (1.4); 7.1869 (1.0); 7.1771 (0.9); 7.0839 (2.8); 6.9161 (6.9); 6.2291 (1.8); 6.2064 (1.8); 4.9808 (5.7); 4.5970 (0.4); 4.5800 (0.6); 4.5660 (0.7); 4.5462 (0.4); 4.1759 (2.0); 4.1577 (4.4); 4.1396 (2.1); 3.9017 (16.0); 3.3259 (142.5); 3.1750 (0.4); 3.1620 (0.3); 3.1322 (2.1); 3.1142 (4.4); 3.0961 (1.9); 2.6791 (0.4); 2.6748 (0.6); 2.6702 (0.8); 2.6658 (0.7); 2.6602 (0.6); 2.6397 (1.0); 2.6297 (0.9); 2.6145 (1.0); 2.6012 (0.6); 2.5234 (1.8); 2.5058 (78.5); 2.5014 (100.9); 2.4969 (73.3); 2.3324 (0.5); 2.3281 (0.6); 2.3236 (0.5); 2.1816 (11.5); 1.9057 (0.5); 1.8947 (0.6); 1.8805 (0.9); 1.8691 (1.0); 1.8542 (0.6); 1.8392 (0.6); 1.8213 (0.4); 1.7157 (0.6); 1.6940 (0.7); 1.6872 (0.6); 1.6699 (0.8); 1.6567 (0.6); 1.6466 (0.5); 1.6302 (0.5); 0.0002 (1.5)
[0841] I-312: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0842] =7.4812 (1.8); 7.4751 (1.4); 7.4721 (1.4); 7.4688 (1.2); 7.4633 (1.4); 7.4583 (2.5); 7.3284 (0.4); 7.3222 (0.6); 7.3092 (2.3); 7.3057 (3.0); 7.2964 (3.7); 7.2864 (3.2); 7.2835 (3.0); 7.2701 (0.7); 7.2648 (0.4); 7.1990 (1.9); 7.1939 (1.3); 7.1852 (1.4); 7.1757 (1.3); 7.0747 (2.3); 7.0555 (3.4); 7.0461 (4.0); 6.9703 (2.3); 6.9512 (1.7); 6.3220 (2.3); 6.3005 (2.4); 5.0296 (0.4); 4.9870 (4.9); 4.9821 (4.9); 4.9514 (0.6); 4.9308 (1.6); 4.9108 (1.6); 4.8908 (0.6); 4.1836 (2.8); 4.1655 (6.3); 4.1474 (3.0); 3.9019 (16.0); 3.6110 (0.8); 3.3237 (104.1); 3.1657 (0.4); 3.1364 (3.0); 3.1184 (6.2); 3.1002 (2.7); 2.8546 (0.5); 2.8479 (0.5); 2.8331 (0.6); 2.8261 (0.6); 2.8158 (0.8); 2.8090 (0.9); 2.7941 (0.9); 2.7872 (0.8); 2.7052 (0.6); 2.6837 (1.2); 2.6747 (0.8); 2.6653 (1.4); 2.6451 (0.8); 2.6242 (0.4); 2.5056 (98.2); 2.5012 (127.3); 2.4967 (94.7); 2.4432 (0.6); 2.4349 (0.6); 2.4238 (0.9); 2.4158 (1.0); 2.4047 (1.0); 2.3931 (1.0); 2.3855 (0.9); 2.3744 (0.6); 2.3667 (0.6); 2.3323 (0.6); 2.3279 (0.8); 2.3232 (0.6); 2.2212 (15.6); 1.7824 (0.4); 1.7608 (1.2); 1.7514 (0.5); 1.7402 (1.1); 1.7300 (1.1); 1.7181 (0.5); 1.7091 (1.1); 1.6874 (0.4); 0.0002 (1.4)
[0843] I-313: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0844] =7.1367 (3.4); 6.9547 (0.4); 6.9347 (8.1); 6.9113 (0.4); 6.2318 (2.0); 6.2091 (2.1); 4.6127 (0.8); 4.6004 (0.9); 4.5784 (0.5); 4.0427 (2.5); 4.0245 (5.5); 4.0064 (2.6); 3.9017 (16.0); 3.6075 (3.5); 3.5890 (3.6); 3.3231 (96.2); 2.9648 (2.7); 2.9467 (5.6); 2.9285 (2.5); 2.6853 (0.7); 2.6701 (1.6); 2.6527 (1.0); 2.6354 (1.2); 2.5943 (0.4); 2.5058 (89.7); 2.5014 (114.4); 2.4969 (83.8); 2.3324 (0.6); 2.3282 (0.7); 2.3239 (0.6); 2.3189 (0.4); 2.2097 (13.9); 1.9061 (1.5); 1.8798 (0.7); 1.8605 (0.5); 1.8165 (0.5); 1.8071 (0.6); 1.7877 (1.0); 1.7815 (1.0); 1.7593 (1.4); 1.7399 (1.0); 1.7348 (1.0); 1.7158 (0.6); 1.6593 (2.3); 1.6159 (2.1); 1.5879 (2.6); 1.1337 (3.0); 1.1160 (1.8); 0.9618 (0.6); 0.9344 (1.3); 0.9068 (1.1); 0.0003 (1.6 )
[0845] I-314: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0846] =7.7033 (2.8); 7.6385 (1.6); 7.6186 (3.1); 7.5793 (1.9); 7.5600 (1.7); 7.5410 (0.7); 7.0894 (1.8); 7.0702 (2.7); 7.0596 (3.4); 6.9829 (1.9); 6.9641 (1.4); 6.3279 (2.0); 6.3060 (2.0); 5.0244 (6.4); 4.9991 (0.6); 4.9788 (1.3); 4.9586 (1.3); 4.9378 (0.5); 4.1103 (2.3); 4.0921 (5.2); 4.0740 (2.5); 4.0629 (0.4); 3.9020 (16.0); 3.5955 (0.5); 3.3239 (106.3); 3.2673 (0.3); 3.1748 (0.3); 3.1632 (0.3); 3.0692 (2.4); 3.0511 (5.2); 3.0328 (2.3); 2.8759 (0.4); 2.8693 (0.4); 2.8543 (0.5); 2.8476 (0.5); 2.8380 (0.7); 2.8308 (0.7); 2.8159 (0.7); 2.8093 (0.7); 2.7204 (0.5); 2.6983 (1.0); 2.6755 (1.1); 2.6706 (0.9); 2.6656 (0.8); 2.6610 (0.8); 2.6386 (0.4); 2.5236 (1.9); 2.5059 (91.0); 2.5015 (117.8); 2.4970 (85.9); 2.4538 (0.7); 2.4458 (0.7); 2.4347 (0.8); 2.4268 (0.9); 2.4154 (0.9); 2.4036 (0.9); 2.3959 (0.8); 2.3848 (0.6); 2.3769 (0.5); 2.3328 (0.7); 2.3283 (0.8); 2.3237 (0.6); 2.2290 (12.6); 1.8224 (0.4); 1.8011 (1.0); 1.7919 (0.4); 1.7801 (1.0); 1.7702 (0.9); 1.7584 (0.4): 1.7493 (0.9); 1.7275 (0.3); 1.1562 (0.6); 0.0002 (1.8)
[0847] 1H-NMR
[0848] I-315: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0849] =7.3367 (0.3); 7.3165 (9.7); 7.3056 (15.3); 7.2840 (0.4); 7.2767 (0.4); 7.2669 (1.2); 7.2568 (1.5); 7.2454 (1.5); 7.2339 (0.8); 7.2239 (0.3); 7.1118 (3.5); 6.9487 (0.4); 6.9290 (8.0); 6.9058 (0.3); 6.2202 (2.0); 6.1974 (2.1); 4.9443 (6.8); 4.6316 (0.4); 4.6146 (0.8); 4.6022 (0.9); 4.5803 (0.5); 4.0980 (2.5); 4.0799 (5.5); 4.0618 (2.6); 3.9018 (16.0); 3.3234 (85.2); 3.1741 (0.4); 3.1618 (0.3); 3.0488 (2.7); 3.0307 (5.7); 3.0125 (2.5); 2.6749 (1.1); 2.6703 (1.1); 2.6652 (1.2); 2.6613 (1.2); 2.6446 (1.1); 2.6287 (1.2); 2.6141 (0.6); 2.5867 (0.4); 2.5055 (86.7); 2.5012 (112.5); 2.4969 (83.9); 2.3321 (0.5); 2.3276 (0.7); 2.3237 (0.7); 2.1939 (14.1); 1.9269 (0.5); 1.8878 (1.5); 1.8785 (1.0); 1.8620 (0.7); 1.8433 (0.5); 1.7732 (0.4); 1.7457 (0.9); 1.7264 (0.9); 1.7213 (0.8); 1.7026 (0.6); 1.6868 (0.4); 1.6712 (0.7); 1.6553 (0.6); 1 6471 (0.7); 1.6310 (0.4); 0.0002 (1.4)
[0850] I-316: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0851] =7.1554 (3.9); 6.9603 (0.6); 6.9403 (8.9); 6.9170 (0.4); 6.1475 (2.3); 6.1248 (2.4); 4.8639 (0.5); 4.8469 (1.3); 4.8295 (1.8); 4.8121 (1.4); 4.7949 (0.5); 4.6400 (0.5); 4.6227 (1.0); 4.6100 (1.1); 4.5884 (0.6); 4.0210 (3.0); 4.0028 (6.5); 3.9848 (3.1); 3.9015 (12.2); 3.3237 (119.1); 3.1741 (0.8); 3.1622 (0.8); 2.9109 (3.3); 2.8928 (6.9); 2.8747 (3.1); 2.7183 (0.4); 2.6909 (0.8); 2.6742 (1.6); 2.6707 (1.6); 2.6604 (1.2); 2.6403 (1.4); 2.6260 (0.7); 2.5978 (0.5); 2.5054 (82.8); 2.5011 (107.2); 2.4967 (81.3); 2.3321 (0.5); 2.3278 (0.7); 2.3236 (0.5); 2.2138 (16.0); 1.9440 (0.6); 1.9233 (1.0); 1.9073 (1.8); 1.8811 (0.8); 1.8610 (0.6); 1.7979 (0.5); 1.7745 (1.1); 1.7554 (0.9); 1.7502 (1.0); 1.7316 (0.5); 1.6981 (0.4); 1.6799 (0.8); 1.6583 (0.8); 1.6372 (0.5); 1.4039 (11.0); 1.3994 (11.5); 1.3867 (11.2); 1.3821 (11.2); 0.0005 (0.9)
[0852] I-317: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0853] =7.8166 (3.1); 7.7993 (1.9); 7.7823 (1.1); 7.6226 (0.7); 7.6038 (1.2); 7.5842 (0.5); 7.1418 (0.7); 6.9317 (2.4); 6.8829 (5.0); 5.8257 (1.2); 5.8032 (1.2); 4.2011 (0.5); 4.1819 (0.5); 4.0738 (0.4); 4.0668 (0.4); 4.0510 (0.4); 4.0416 (0.4); 4.0342 (0.5); 4.0250 (0.4); 3.9653 (0.8); 3.9593 (0.7); 3.9509 (1.3); 3.9447 (1.2); 3.9274 (0.7); 3.9069 (2.2); 3.9020 (16.0); 3.8596 (0.4); 3.8512 (0.5); 3.8391 (0.4); 3.8288 (0.6); 3.8184 (0.4); 3.8066 (0.3); 3.7694 (0.4); 3.7537 (0.8); 3.7392 (0.4); 3.3244 (73.0); 3.1883 (0.5); 3.1740 (0.6); 2.6754 (0.5); 2.6706 (0.7); 2.6662 (0.6); 2.5746 (0.7); 2.5603 (0.7); 2.5482 (0.7); 2.5235 (1.9); 2.5060 (77.8); 2.5016 (100.4); 2.4972 (74.6); 2.3281 (1.0); 2.3235 (0.9); 2.3184 (1.0); 2.3072 (0.7); 2.3025 (0.7); 2.2926 (0.7); 2.2775 (0.5); 2.2137 (2.9); 2.1749 (8.2); 1.9726 (0.4); 1.9596 (0.4); 1.9466 (0.3); 1.8721 (0.4); 1.8611 (0.3); 1.7440 (0.5); 1.7320 (0.5); 1.7069 (0.4); 1.6152 (0.4); 1.5905 (0.5); 1.5578 (0.4); 1.4758 (0.8); 1.4590 (1.0); 0.0002 (1.3)
[0854] I-318: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0855] =7.1478 (2.6); 6.9324 (5.7); 6.1434 (1.5); 6.1208 (1.5); 4.6469 (0.3); 4.6283 (0.6); 4.6164 (0.7); 4.5945 (0.4); 3.9458 (1.5); 3.9306 (3.3); 3.9151 (1.6); 3.9018 (16.0); 3.8902 (0.4); 3.8696 (0.8); 3.8569 (2.0); 3.8423 (2.1); 3.8295 (0.8); 3.5927 (0.6); 3.5853 (0.6); 3.5741 (1.0); 3.5616 (0.7); 3.5540 (0.6); 3.3244 (100.6); 3.1747 (0.4); 3.1623 (0.4); 2.6702 (1.2); 2.6662 (1.1); 2.6526 (0.9); 2.6367 (0.9); 2.6228 (0.5); 2.5058 (68.6); 2.5015 (88.8); 2.4971 (66.0); 2.3282 (0.6); 2.3234 (0.5); 2.3187 (0.5); 2.2092 (10.7); 2.1016 (0.5); 2.0879 (1.4); 2.0735 (1.9); 2.0592 (1.4); 2.0446 (0.5); 1.9447 (0.4); 1.9309 (0.5); 1.9253 (0.5); 1.9153 (0.9); 1.9035 (1.2); 1.8928 (0.7); 1.8735 (0.6); 1.8589 (0.4); 1.7781 (0.7); 1.7580 (0.6); 1.7347 (0.4); 1.6837 (0.5); 1.6612 (0.5); 1.6377 (0.4); 1.2355 (0.4); 0.9109 (0.4); 0.8984 (1.4); 0.8912 (2.5); 0.8879 (2.4); 0.8797 (2.2); 0.8596 (2.3); 0.8521 (1.3); 0.8398 (2.2); 0.8326 (1.2); 0.8201 (0.5); 0.0002 (1.2)
[0856] I-320: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0857] =7.1014 (3.9); 7.0793 (2.7); 6.9909 (2.0); 6.9720 (1.4); 6.1947 (2.0); 6.1730 (2.0); 5.0210 (0.5); 5.0006 (1.3); 4.9807 (1.3); 4.9603 (0.5); 3.9315 (2.1); 3.9161 (4.5); 3.9019 (16.0); 3.8476 (2.1); 3.8336 (2.4); 3.8195 (2.2); 3.3215 (57.2); 2.8887 (0.4); 2.8822 (0.4); 2.8675 (0.5); 2.8599 (0.5); 2.8503 (0.7); 2.8431 (0.7); 2.8286 (0.7); 2.8215 (0.7); 2.7328 (0.5); 2.7119 (1.0); 2.6916 (0.8); 2.6707 (1.0); 2.6523 (0.4); 2.5181 (24.5); 2.5100 (35.6); 2.5057 (69.7); 2.5013 (90.5); 2.4968 (65.8); 2.4704 (0.8); 2.4626 (0.7); 2.4513 (0.9); 2.4436 (0.9); 2.4319 (0.9); 2.4203 (0.9); 2.4126 (0.9); 2.4012 (0.6); 2.3935 (0.4); 2.3324 (0.4); 2.3278 (0.6); 2.3234 (0.4); 2.2538 (13.7); 2.0980 (0.6); 2.0833 (1.6); 2.0688 (2.1); 2.0545 (1.6); 2.0397 (0.6); 1.8534 (0.4); 1.8317 (1.0); 1.8227 (0.4); 1.8108 (1.0); 1.8009 (1.0); 1.7889 (0.4); 1.7797 (1.0); 1.7578 (0.3); 0.0002 (1.4)
[0858] 1H-NMR
[0859] I-321: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0860] =7.1474 (2.6); 6.9586 (0.3); 6.9386 (5.6); 6.0994 (1.4); 6.0768 (1.5); 4.6545 (0.3); 4.6367 (0.6); 4.6255 (0.7); 4.6042 (0.4); 3.9224 (1.6); 3.9067 (3.7); 3.9019 (16.0); 3.8920 (1.8); 3.8410 (1.2); 3.8329 (1.6); 3.8252 (1.6); 3.8165 (1.2); 3.7508 (0.4); 3.3235 (67.2); 3.1740 (0.7); 3.1619 (0.6); 2.6901 (0.5); 2.6750 (1.1); 2.6706 (1.2); 2.6591 (0.9); 2.6402 (1.0); 2.6254 (0.6); 2.5979 (0.3); 2.5183 (17.6); 2.5057 (61.7); 2.5013 (80.3); 2.4970 (59.9); 2.3323 (0.4); 2.3281 (0.5); 2.3232 (0.4); 2.3181 (0.4); 2.2134 (11.7); 2.0936 (0.4); 2.0786 (1.2); 2.0642 (1.6); 2.0501 (1.2); 2.0354 (0.4); 1.9561 (0.4); 1.9404 (0.5); 1.9205 (0.7); 1.9080 (1.2); 1.8791 (0.6); 1.8599 (0.5); 1.7730 (0.7); 1.7539 (0.6); 1.7493 (0.7); 1.7306 (0.4); 1.6799 (0.5); 1.6605 (0.6); 1.6390 (0.4); 0.0002 (0.8)
[0861] I-322: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0862] =7.3082 (1.8); 7.2907 (2.4); 7.2243 (1.3); 7.2069 (2.7); 7.1882 (1.3); 7.1724 (2.3); 7.1545 (2.6); 7.1349 (1.8); 7.1171 (0.6); 6.2411 (2.2); 6.2192 (2.3); 5.0606 (0.6); 5.0406 (1.6); 5.0204 (1.6); 5.0004 (0.6); 3.9323 (2.4); 3.9170 (5.0); 3.9018 (16.0); 3.8468 (2.3); 3.8329 (2.7); 3.8187 (2.4); 3.7581 (0.3); 3.3267 (136.8); 3.1749 (0.4); 3.1620 (0.4); 2.9548 (0.5); 2.9469 (0.6); 2.9328 (0.6); 2.9251 (0.6); 2.9156 (0.9); 2.9077 (0.9); 2.8937 (0.9); 2.8859 (0.9); 2.7968 (0.6); 2.7759 (1.3); 2.7557 (1.1); 2.7365 (0.8); 2.7157 (0.5); 2.6705 (0.6); 2.5060 (79.7); 2.5017 (101.7); 2.4973 (75.5); 2.4619 (1.2); 2.4535 (1.2); 2.4424 (1.2); 2.4309 (1.2); 2.4230 (1.0); 2.4120 (0.6); 2.4037 (0.5); 2.3281 (0.6); 2.3241 (0.5); 2.0983 (0.6); 2.0831 (1.8); 2.0688 (2.4); 2.0545 (1.8); 2.0392 (0.6); 1.9086 (0.4); 1.8816 (0.5); 1.8601 (1.2); 1.8509 (0.5); 1.8392 (1.2); 1.8290 (1.1); 1.8175 (0.5); 1.8083 (1.1); 1.7864 (0.4); 0.0002 (0.7)
[0863] I-324: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0864] =7.2914 (2.0); 7.2725 (2.2); 7.1330 (1.0); 7.1292 (1.0); 7.1119 (2.0); 7.0945 (1.3); 7.0906 (1.2); 6.8525 (1.4); 6.8501 (1.6); 6.8317 (2.6); 6.8154 (1.2); 6.8129 (1.2); 6.7502 (2.8); 6.7485 (2.8); 6.7298 (2.5); 6.3856 (2.3); 6.3639 (2.4); 4.7339 (0.6); 4.7202 (1.3); 4.7077 (0.9); 4.6993 (1.3); 4.6853 (0.6); 4.2799 (0.5); 4.2706 (0.6); 4.2605 (0.5); 4.2518 (1.4); 4.2422 (1.2); 4.2336 (1.1); 4.2237 (1.0); 4.2021 (0.9); 4.1919 (1.2); 4.1877 (1.3); 4.1766 (1.2); 4.1647 (0.6); 4.1590 (0.6); 4.1497 (0.5); 3.9338 (2.4); 3.9184 (5.3); 3.9022 (16.0); 3.8849 (0.3); 3.8714 (0.5); 3.8518 (1.2); 3.8382 (3.2); 3.8229 (3.2); 3.8092 (1.2); 3.7898 (0.5); 3.3244 (95.2); 3.1720 (0.5); 2.6754 (0.5); 2.6707 (0.6); 2.6664 (0.4); 2.5169 (28.4); 2.5102 (41.1); 2.5061 (80.3); 2.5017 (104.6); 2.4973 (77.0); 2.3330 (0.5); 2.3284 (0.6); 2.3238 (0.5); 2.0970 (0.8); 2.0822 (2.3); 2.0673 (3.6); 2.0527 (3.6); 2.0368 (2.8); 2.0268 (1.8); 2.0123 (0.8); 2.0025 (0.5); 1.2117 (0.4); 1.1956 (0.4); 0.0000 (0.8)
[0865] I-325: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0866] =7.6694 (0.4); 7.2500 (0.3); 7.1373 (2.0); 6.9324 (4.7); 6.1919 (1.2); 6.1694 (1.2); 4.5992 (0.5); 4.5865 (0.6); 4.2175 (0.7); 4.2004 (1.0); 4.1834 (0.8); 3.9247 (1.3); 3.9096 (2.7); 3.9019 (16.0); 3.8351 (1.2); 3.8217 (1.6); 3.8083 (1.3); 3.3243 (82.8); 3.1719 (0.6); 3.1647 (0.6); 2.8904 (0.4); 2.6707 (1.0); 2.6668 (0.9); 2.6507 (0.6); 2.6324 (0.7); 2.5879 (0.5); 2.5717 (0.5); 2.5548 (0.4); 2.5060 (70.1); 2.5018 (89.9); 2.4980 (68.2); 2.3430 (0.5); 2.3281 (0.6); 2.3179 (2.0); 2.2100 (8.3); 2.1448 (1.1); 2.1315 (1.4); 2.1177 (1.1); 2.0303 (0.3); 2.0144 (0.5); 1.9175 (0.6); 1.9043 (1.0); 1.8931 (0.8); 1.8769 (0.5); 1.7569 (0.6); 1.7331 (0.6); 1.7138 (0.4); 1.6762 (0.4); 1.6574 (0.4); 1.3009 (6.0); 1.2949 (6.2); 1.2838 (6.2); 1.2779 (5.9); 0.0002 (0.7)
[0867] I-326: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0868] =7.3109 (1.0); 7.2935 (1.2); 7.2218 (0.7); 7.2042 (1.5); 7.1843 (0.7); 7.1691 (1.2); 7.1485 (1.5); 7.1305 (1.0); 7.1111 (0.4); 6.3017 (1.2); 6.2800 (1.3); 5.0229 (0.8); 5.0023 (0.8); 4.9827 (0.3); 3.9255 (1.2); 3.9104 (2.7); 3.9018 (16.0); 3.8134 (1.2); 3.8001 (1.6); 3.7862 (1.4); 3.3227 (55.7); 3.2190 (0.5); 3.2111 (0.6); 3.1994 (1.0); 3.1871 (0.6); 3.1791 (0.7); 3.1668 (0.9); 2.9349 (0.3); 2.9265 (0.3); 2.9164 (0.5); 2.9091 (0.5); 2.8955 (0.5); 2.8876 (0.5); 2.7936 (0.3); 2.7721 (0.7); 2.7520 (0.6); 2.7325 (0.4); 2.6703 (0.4); 2.5235 (0.9); 2.5099 (27.2); 2.5057 (55.8); 2.5012 (73.9); 2.4967 (55.0); 2.4687 (0.8); 2.4579 (0.8); 2.4495 (0.7); 2.4382 (0.7); 2.4270 (0.7); 2.4188 (0.6); 2.4077 (0.4); 2.3996 (0.4); 2.3329 (0.4); 2.3279 (0.5); 2.3235 (0.4); 2.1765 (0.4); 2.1614 (1.0); 2.1478 (1.2); 2.1339 (1.0); 1.8488 (0.6); 1.8280 (0.6); 1.8176 (0.6); 1.7973 (0.6); 1.1789 (0.4); 1.1605 (1.8); 1.1493 (1.8); 1.1390 (0.7); 1.0919 (0.5); 1.0787 (1.6); 1.0726 (1.2); 1.0585 (1.5); 0.0002 (1.1)
[0869] 1H-NMR
[0870] I-327: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0871] =7.1477 (1.3); 6.9359 (2.8); 6.1449 (0.8); 6.1221 (0.8); 4.6146 (0.4); 3.9170 (0.9); 3.9017 (16.0); 3.8867 (0.9); 3.8119 (0.8); 3.7982 (1.0); 3.7847 (0.9); 3.3240 (61.7); 3.2240 (0.4); 3.2160 (0.4); 3.2042 (0.7); 3.1920 (0.4); 3.1842 (0.4); 3.1729 (0.5); 3.1629 (0.3); 2.6748 (0.6); 2.6705 (0.7); 2.6609 (0.4); 2.6391 (0.4); 2.5236 (0.9); 2.5102 (22.1); 2.5059 (44.8); 2.5014 (58.8); 2.4968 (43.1); 2.4925 (21.8); 2.3281 (0.4); 2.3175 (1.1); 2.2103 (5.5); 2.1587 (0.7); 2.1447 (0.9); 2.1305 (0.7); 1.9218 (0.4); 1.9084 (0.6); 1.8964 (0.5); 1.8808 (0.3); 1.7612 (0.4); 1.7429 (0.3); 1.7379 (0.3); 1.1651 (1.1); 1.1564 (1.1); 1.1449 (0.6); 1.0976 (0.4); 1.0843 (1.1); 1.0782 (0.9); 1.0641 (1.0); 1.0596 (0.8); 0.0002 (0.6)
[0872] I-328: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0873] =7.4773 (0.3); 7.1070 (1.8); 7.0915 (1.1); 7.0725 (1.5); 6.9850 (1.2); 6.9658 (0.8); 6.2948 (0.9); 6.2736 (1.0); 4.9538 (0.7); 4.9337 (0.7); 4.2221 (0.6); 4.2051 (0.9); 4.1879 (0.7); 3.9312 (1.1); 3.9162 (2.3); 3.9017 (16.0); 3.8377 (1.2); 3.8247 (1.5); 3.8109 (1.2); 3.3240 (55.5); 3.1684 (1.0); 2.8490 (0.4); 2.8427 (0.4); 2.8285 (0.4); 2.8212 (0.4); 2.7042 (0.6); 2.6835 (0.5); 2.6661 (0.7); 2.5054 (64.0); 2.5013 (81.4); 2.4971 (61.1); 2.4566 (0.5); 2.4483 (0.5); 2.4370 (0.6); 2.4295 (0.6); 2.4181 (0.6); 2.4064 (0.6); 2.3988 (0.6); 2.3872 (0.4); 2.3791 (0.4); 2.3672 (1.2); 2.3276 (0.6); 2.2769 (0.3); 2.2485 (7.1); 2.1478 (0.9); 2.1342 (1.2); 2.1214 (1.0); 2.0921 (0.4); 2.0110 (0.4); 1.8176 (0.5); 1.7967 (0.6); 1.7874 (0.5); 1.7658 (0.5); 1.2973 (6.3); 1.2821 (6.3); 1.2489 (0.3); 0.0002 (0.7)
[0874] I-329: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0875] =7.1442 (2.6); 6.9363 (6.1); 6.1898 (1.5); 6.1669 (1.6); 4.6363 (0.3); 4.6184 (0.6); 4.6060 (0.7); 4.5851 (0.4); 3.9019 (16.0); 3.8883 (3.3); 3.8731 (1.6); 3.8070 (1.6); 3.7936 (2.0); 3.7800 (1.7); 3.4124 (15.2); 3.3221 (43.8); 3.2670 (0.4); 3.1685 (2.0); 2.6877 (0.5); 2.6701 (1.2); 2.6550 (0.8); 2.6374 (0.9); 2.6228 (0.5); 2.5232 (1.5); 2.5097 (33.5); 2.5056 (66.1); 2.5012 (85.8); 2.4967 (63.4); 2.4926 (32.5); 2.3323 (0.4); 2.3279 (0.6); 2.3231 (0.5); 2.3181 (0.6); 2.2115 (10.9); 2.1807 (0.5); 2.1665 (1.3); 2.1530 (1.6); 2.1388 (1.2); 1.9385 (0.4); 1.9327 (0.5); 1.9203 (0.7); 1.9070 (1.2); 1.8951 (1.0); 1.8792 (0.6); 1.8596 (0.4); 1.7590 (0.7); 1.7400 (0.6); 1.7344 (0.7); 1.7155 (0.4); 1.6789 (0.5); 1.6590 (0.5); 1.6393 (0.4); 0.0002 (1.1)
[0876] I-330: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0877] =7.1646 (2.5); 6.9690 (0.4); 6.9485 (5.3); 6.1103 (1.5); 6.0877 (1.6); 4.7058 (0.3); 4.6765 (0.6); 4.6566 (0.3); 3.9116 (1.5); 3.9018 (16.0); 3.8970 (3.8); 3.8814 (1.8); 3.8708 (0.6); 3.8635 (0.9); 3.8550 (0.7); 3.8341 (1.1); 3.8215 (1.8); 3.8068 (1.7); 3.7951 (0.8); 3.3246 (96.3); 2.6983 (0.4); 2.6810 (0.8); 2.6750 (0.8); 2.6707 (1.0); 2.6663 (1.0); 2.6478 (0.8); 2.6334 (0.4); 2.5239 (1.3); 2.5103 (31.8); 2.5062 (63.2); 2.5017 (82.1); 2.4972 (60.0); 2.3329 (0.4); 2.3285 (0.5); 2.3238 (0.4); 2.2176 (10.4); 2.0767 (0.4); 2.0622 (1.3); 2.0478 (1.8); 2.0332 (1.3); 2.0180 (0.4); 1.9270 (0.8); 1.9044 (1.2); 1.8404 (1.0); 1.8141 (1.4); 1.7755 (0.7); 1.7522 (0.4); 1.6984 (1.2); 1.6937 (1.2); 1.6761 (1.6); 1.6167 (0.8); 1.5931 (0.6); 1.3358 (0.7); 1.3110 (1.0); 1.2822 (1.2); 1.2493 (1.2); 1.2131 (1.0); 1.1903 (1.1); 1.1697 (0.6); 1.1386 (0.3); 0.0002 (0.6)
[0878] I-331: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0879] =7.3418 (1.1); 7.3269 (1.2); 7.3198 (1.2); 7.1204 (1.3); 7.1157 (2.0); 7.1068 (3.4); 7.0983 (2.6); 7.0927 (1.7); 7.0800 (0.6); 7.0664 (1.5); 7.0588 (1.2); 7.0441 (0.8); 6.1677 (1.5); 6.1450 (1.6); 4.6987 (0.4); 4.6787 (0.6); 4.6679 (0.7); 4.6455 (0.4); 3.9205 (1.7); 3.9017 (16.0); 3.8898 (1.8); 3.8467 (0.9); 3.8343 (1.9); 3.8215 (1.9); 3.8092 (0.9); 3.3260 (95.7); 3.1751 (0.6); 3.1624 (0.6); 2.7459 (0.6); 2.7279 (0.8); 2.7135 (1.0); 2.6963 (1.0); 2.6806 (0.7); 2.6710 (0.7); 2.5112 (42.5); 2.5061 (61.2); 2.5018 (76.9); 2.4974 (56.2); 2.3327 (0.4); 2.3286 (0.5); 2.0923 (0.5); 2.0775 (1.4); 2.0633 (1.9); 2.0488 (1.4); 2.0337 (0.5); 1.9965 (0.4); 1.9807 (0.3); 1.9469 (0.9); 1.9311 (2.1); 1.9201 (1.5); 1.9074 (0.8); 1.8882 (0.5); 1.8315 (0.4); 1.8265 (0.4); 1.8035 (0.8); 1.7836 (0.7); 1.7612 (0.5); 1.7305 (0.4); 1.7118 (0.6); 1.6955 (0.6); 1.6741 (0.4); 0.0001 (0.3)
[0880] 1H-NMR
[0881] I-332: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0882] =7.3629 (0.4); 7.3442 (0.5); 7.3273 (0.7); 7.3119 (0.7); 7.3064 (0.7); 7.1140 (0.6); 7.1071 (0.8); 7.0989 (1.8); 7.0919 (1.0); 7.0830 (0.8); 7.0598 (0.9); 7.0534 (0.7); 7.0377 (0.5); 6.2708 (0.7); 6.2482 (0.7); 4.6354 (0.4); 4.6241 (0.4); 4.2059 (0.6); 4.1887 (0.9); 4.1716 (0.6); 3.9203 (1.0); 3.9018 (16.0); 3.8907 (1.1); 3.8318 (0.9); 3.8188 (1.3); 3.8049 (1.0); 3.3271 (58.8); 3.1684 (1.0); 2.9460 (0.4); 2.7189 (0.4); 2.7053 (0.5); 2.6896 (0.6); 2.6750 (0.6); 2.6709 (0.5); 2.6660 (0.4); 2.6000 (0.3); 2.5238 (1.0); 2.5103 (24.7); 2.5060 (50.3); 2.5015 (66.3); 2.4970 (49.0); 2.4929 (25.1); 2.3283 (0.4); 2.3242 (0.3); 2.1427 (0.8); 2.1291 (1.0); 2.1156 (0.8); 2.0419 (0.4); 1.9392 (0.5); 1.9250 (0.7); 1.9149 (0.8); 1.9017 (0.4); 1.7862 (0.4); 1.7667 (0.4); 1.6905 (0.3); 1.2969 (4.6); 1.2866 (4.9); 1.2798 (4.9); 1.2695 (4.4); 0.0002 (0.5)
[0883] I-333: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0884] =7.3385 (0.7); 7.3230 (0.8); 7.3164 (0.8); 7.1172 (0.7); 7.1121 (1.3); 7.1033 (2.2); 7.0949 (1.5); 7.0887 (1.0); 7.0759 (0.4); 7.0641 (1.0); 7.0567 (0.8); 7.0476 (0.4); 7.0418 (0.5); 6.2176 (1.1); 6.1950 (1.1); 4.6641 (0.4); 4.6529 (0.5); 3.9138 (1.1); 3.9017 (16.0); 3.8837 (1.1); 3.8094 (1.0); 3.7963 (1.3); 3.7827 (1.1); 3.3296 (102.4); 3.2119 (0.4); 3.2040 (0.5); 3.1922 (0.9); 3.1800 (0.6); 3.1747 (0.9); 3.1617 (0.8); 2.7439 (0.4); 2.7259 (0.5); 2.7124 (0.6); 2.6954 (0.7); 2.6799 (0.5); 2.6756 (0.5); 2.6707 (0.5); 2.6667 (0.4); 2.5238 (1.2); 2.5103 (25.7); 2.5061 (51.1); 2.5016 (66.6); 2.4971 (48.8); 2.3284 (0.4); 2.3236 (0.3); 2.1568 (0.8); 2.1432 (1.0); 2.1293 (0.8); 2.1140 (0.3); 1.9446 (0.6); 1.9307 (0.9); 1.9196 (0.9); 1.9057 (0.5); 1.7914 (0.5); 1.7712 (0.5); 1.7486 (0.3); 1.7116 (0.3); 1.6957 (0.4); 1.1600 (1.3); 1.1513 (1.3); 1.1398 (0.5): 1.0914 (0.4); 1.0777 (1.4); 1.0723 (1.1); 1.0577 (1.3): -0.0002 (0.6)
[0885] I-334: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0886] =7.6506 (0.4); 7.3098 (0.8); 7.2913 (1.0); 7.2196 (0.6); 7.2020 (1.2); 7.1835 (0.6); 7.1678 (1.0); 7.1459 (1.0); 7.1268 (0.8); 6.3455 (0.7); 6.3241 (0.7); 4.9925 (0.6); 4.9730 (0.6); 4.2113 (0.7); 4.1940 (0.9); 4.1768 (0.7); 3.9328 (1.1); 3.9176 (2.3); 3.9018 (16.0); 3.8370 (1.1); 3.8237 (1.4); 3.8095 (1.2); 3.7903 (0.4); 3.3269 (61.6); 3.1685 (2.3); 2.9138 (0.4); 2.9057 (0.4); 2.8917 (0.4); 2.8844 (0.4); 2.7679 (0.6); 2.7478 (0.4); 2.7284 (0.4); 2.6749 (0.3); 2.6707 (0.5); 2.6465 (0.3); 2.5236 (1.3); 2.5060 (66.8); 2.5016 (86.3); 2.4972 (63.0); 2.4625 (0.6); 2.4511 (0.6); 2.4427 (0.6); 2.4318 (0.6); 2.4206 (0.6); 2.4122 (0.5); 2.3326 (0.4); 2.3283 (0.6); 2.3237 (0.4); 2.1479 (0.9); 2.1345 (1.1): 2.1209 (0.9); 1.8408 (0.5); 1.8204 (0.5); 1.8097 (0.5); 1.7895 (0.5); 1.2970 (5.4); 1.2912 (6.5); 1.2799 (5.4); 1.2740 (6.1); 1.2536 (0.5); 1.2363 (0.6); 0.0002 (0.5)
[0887] I-336: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0888] =7.1098 (2.0); 7.0961 (1.2); 7.0770 (1.6); 6.9882 (1.2); 6.9686 (0.9); 6.2517 (1.2); 6.2299 (1.3); 4.9845 (0.8); 4.9644 (0.8); 3.9246 (1.2); 3.9094 (2.8); 3.9017 (16.0); 3.8150 (1.2); 3.8014 (1.5); 3.7878 (1.3); 3.3295 (131.4); 3.2280 (0.5); 3.2200 (0.6); 3.2084 (1.0); 3.1963 (0.6); 3.1883 (0.5); 3.1751 (0.6); 3.1621 (0.5); 2.8532 (0.4); 2.8456 (0.4); 2.8315 (0.4); 2.8240 (0.4); 2.7094 (0.6); 2.6894 (0.5); 2.6706 (0.8); 2.5238 (1.3); 2.5061 (53.7); 2.5017 (69.9); 2.4973 (51.4); 2.4641 (0.4); 2.4562 (0.3); 2.4449 (0.5); 2.4371 (0.5); 2.4256 (0.5); 2.4141 (0.6); 2.4062 (0.5); 2.3955 (0.3); 2.3673 (0.4); 2.3328 (0.4); 2.3283 (0.4); 2.3241 (0.3); 2.2493 (8.1); 2.1769 (0.4); 2.1621 (1.0); 2.1483 (1.2); 2.1349 (1.0); 2.1195 (0.4); 1.8236 (0.6); 1.8028 (0.6); 1.7928 (0.6); 1.7719 (0.6); 1.1841 (0.4); 1.1712 (1.1); 1.1653 (1.7); 1.1544 (1.7); 1.1443 (0.7); 1.0960 (0.5); 1.0829 (1.5); 1.0771 (1.2); 1.0628 (1.5); 0.0001 (0.7)
[0889] I-337: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0890] =7.2856 (1.0); 7.2666 (1.1); 7.1264 (0.5); 7.1226 (0.5); 7.1053 (1.0); 7.0880 (0.7); 7.0844 (0.6); 6.8383 (0.8); 6.8199 (1.3); 6.8037 (0.6); 6.8011 (0.6); 6.7403 (1.4); 6.7216 (1.2); 6.7198 (1.2); 6.4755 (1.2); 6.4539 (1.2); 4.6809 (0.6); 4.6718 (0.5); 4.6596 (0.6); 4.2442 (0.7); 4.2360 (0.6); 4.2250 (0.8); 4.2159 (0.6); 4.2075 (0.8); 4.1901 (1.4); 4.1826 (0.7); 4.1729 (1.3); 4.1553 (0.6); 3.9366 (1.1); 3.9216 (2.3); 3.9017 (16.0); 3.8366 (1.0); 3.8233 (1.4); 3.8099 (1.1); 3.3262 (91.9); 3.1747 (0.8); 3.1616 (0.8); 2.6706 (0.3); 2.5099 (22.7); 2.5058 (45.1); 2.5014 (59.1); 2.4969 (44.0); 2.3277 (0.4); 2.1490 (0.9); 2.1351 (1.1); 2.1212 (0.8); 2.1069 (0.3); 2.0558 (0.4); 2.0453 (0.5); 2.0344 (0.8); 2.0236 (0.9); 2.0106 (0.8); 1.9950 (0.4); 1.2996 (5.1); 1.2929 (5.4); 1.2824 (5.2); 1.2758 (5.2)
[0891] 1H-NMR
[0892] I-338: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0893] =7.2921 (1.0); 7.2742 (1.0); 7.1301 (0.5); 7.1259 (0.5); 7.1086 (1.0); 7.0912 (0.6); 7.0874 (0.6); 6.8478 (0.7); 6.8453 (0.7); 6.8269 (1.2); 6.8107 (0.6); 6.8082 (0.6); 6.7473 (1.4); 6.7270 (1.2); 6.4326 (1.2); 6.4108 (1.2); 4.7073 (0.6); 4.6964 (0.4); 4.6854 (0.6); 4.2518 (0.7); 4.2426 (0.6); 4.2327 (0.5); 4.2237 (0.4); 4.2023 (0.4); 4.1925 (0.5); 4.1878 (0.6); 4.1768 (0.6); 3.9285 (1.1); 3.9133 (2.4); 3.9017 (16.0); 3.8145 (1.1); 3.8011 (1.4); 3.7871 (1.1); 3.3282 (110.3); 3.2157 (0.5); 3.2074 (0.5); 3.1960 (0.9); 3.1839 (0.5); 3.1752 (1.0); 3.1620 (0.7); 2.6706 (0.4); 2.5238 (1.1); 2.5103 (23.6); 2.5061 (46.8); 2.5016 (60.8); 2.4971 (44.4); 2.3283 (0.4); 2.1771 (0.3); 2.1616 (0.8); 2.1480 (1.1); 2.1346 (0.8); 2.0613 (0.4); 2.0520 (0.5); 2.0422 (0.8); 2.0284 (0.9); 2.0186 (0.8); 2.0029 (0.4); 1.1645 (1.3); 1.1566 (1.4); 1.1455 (0.7); 1.1395 (0.4); 1.0978 (0.4); 1.0844 (1.4); 1.0783 (1.1); 1.0644 (1.3); 1.0593 (1.0); 0.0002 (0.4)
[0894] I-340: .sup.1H-NMR(400.0 MHz, CDCl3):
[0895] =7.5184 (1.0); 7.3108 (0.5); 7.2595 (182.0); 7.2103 (0.6); 7.0852 (1.6); 7.0671 (4.8); 7.0223 (2.3); 7.0025 (1.2); 6.9955 (1.3); 4.9028 (3.8); 4.8700 (2.8); 4.7597 (1.7); 4.7390 (1.7); 4.2035 (1.1); 4.1897 (2.0); 4.1756 (2.3); 4.1642 (2.7); 4.1147 (1.6); 4.1016 (1.6); 3.4911 (4.0); 3.0615 (0.9); 3.0417 (1.0); 3.0231 (1.1); 3.0042 (1.2); 2.5209 (1.3); 2.4980 (1.6); 2.4833 (1.3); 2.4602 (1.5); 2.3011 (16.0); 2.2684 (1.6); 2.2510 (1.1); 2.2290 (0.6); 1.2872 (10.2); 1.2705 (10.2); 0.0079 (1.8); 0.0002 (64.6); 0.0085 (2.8)
[0896] I-341: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0897] =9.4632 (2.3); 8.3152 (0.6); 7.6870 (0.9); 7.6694 (1.2); 7.6500 (1.6); 7.6302 (1.1); 7.6008 (0.9); 7.5823 (0.8); 7.5025 (0.4); 7.4387 (0.7); 7.4206 (0.9); 7.4016 (0.5); 7.3535 (0.3); 7.3376 (0.4); 7.2988 (0.4); 7.2761 (2.4); 7.2584 (6.3); 7.2406 (7.8); 7.2233 (6.6); 7.2032 (3.1); 7.1870 (5.0); 7.1788 (3.3); 7.1695 (2.9); 7.1555 (5.2); 7.1355 (5.4); 7.1175 (1.9); 7.0967 (0.4); 6.4547 (1.5); 6.4328 (1.6); 6.3726 (0.5); 6.3484 (0.6); 6.3267 (0.5); 5.0703 (2.6); 5.0544 (2.9); 4.7961 (2.4); 4.7481 (5.3); 4.6964 (0.6); 4.3834 (14.6); 4.3273 (1.6); 4.2122 (0.4); 4.1950 (0.5); 4.1810 (0.5); 4.1563 (3.9); 4.1419 (7.5); 4.1281 (4.9); 4.1087 (2.0); 4.0984 (2.0); 4.0708 (12.6); 4.0052 (0.7); 4.0005 (0.7); 3.9637 (0.6); 3.9318 (0.4); 3.9019 (15.0); 3.8365 (0.5); 3.7679 (0.7); 3.6798 (5.1); 3.6659 (8.3); 3.6515 (5.5); 3.6232 (3.4); 3.5848 (4.7); 3.5028 (16.0); 3.3232 (1.9); 3.2257 (0.6); 3.2119 (0.6); 3.1681 (15.5); 3.1244 (1.0); 3.1103 (1.0); 3.0955 (1.0); 3.0764 (0.4); 3.0574 (0.4); 2.9543 (1.6); 2.9416 (1.5); 2.9332 (1.7); 2.9234 (2.2); 2.9152 (2.6); 2.9023 (2.2); 2.8929 (2.4); 2.8033 (1.3); 2.7831 (2.8); 2.7628 (2.2); 2.7432 (1.6); 2.7231 (0.8); 2.6746 (2.4); 2.6705 (3.4); 2.6663 (2.4); 2.6461 (0.8); 2.6314 (0.6); 2.6169 (0.6); 2.5408 (2.0); 2.5235 (7.1); 2.5058 (517.4); 2.5015 (681.6); 2.4972 (503.8); 2.4617 (5.6); 2.4520 (5.2); 2.4416 (4.3); 2.4305 (4.2); 2.4220 (3.6); 2.4109 (2.4); 2.4026 (2.1); 2.3663 (0.9); 2.3595 (0.9); 2.3325 (3.3); 2.3281 (4.4); 2.3240 (3.4); 2.2830 (0.6); 2.2226 (0.5); 2.2192 (0.5); 2.2049 (0.5); 2.1788 (0.4); 2.1553 (0.4); 2.1047 (0.4); 2.0897 (0.4); 1.9083 (0.4); 1.8689 (1.0); 1.8605 (0.8); 1.8472 (2.4); 1.8379 (2.2); 1.8268 (2.6); 1.8165 (3.3); 1.8060 (2.0); 1.7958 (2.6); 1.7869 (1.5); 1.7738 (0.9); 1.7657 (0.6); 1.3359 (0.3); 1.2585 (0.4); 1.2496 (0.6); 1.2357 (0.8); 0.0003 (5.4)
[0898] I-342: .sup.1H-NMR(400.0() MHz, CDCl3):
[0899] =7.5187 (1.9); 7.3249 (7.3); 7.3058 (7.9); 7.2598 (322.4); 7.2057 (3.4); 7.1852 (7.1); 7.1671 (4.4); 6.9958 (1.9); 6.9161 (5.4); 6.8973 (9.1); 6.8787 (4.3); 6.8518 (9.8); 6.8313 (8.6); 4.8524 (16.0); 4.8232 (14.1); 4.8084 (9.6); 4.7964 (4.7); 4.3012 (1.4); 4.2904 (2.6); 4.2734 (5.6); 4.2594 (8.4); 4.2488 (8.9); 4.2346 (5.0); 4.2266 (5.8); 4.2068 (2.3); 4.1982 (2.9); 4.1799 (4.5); 4.1684 (6.8); 4.1525 (9.1); 4.1418 (11.2); 4.0935 (6.1); 4.0800 (7.0); 4.0677 (3.3); 3.4907 (2.8); 2.2736 (1.0); 2.2635 (1.5); 2.2527 (1.6); 2.2394 (3.2); 2.2287 (4.6); 2.2175 (5.0); 2.2062 (6.4); 2.1958 (5.8); 2.1840 (3.9); 2.1709 (2.2); 2.1570 (1.4); 0.0079 (4.9); 0.0002 (120.2); 0.0085 (3.6)
[0900] I-343: .sup.1H-NMR(400.0 MHz, CDCl3):
[0901] =7.5183 (0.8); 7.2595 (154.0); 7.0678 (1.9); 7.0499 (6.7); 7.0089 (2.7); 6.9953 (1.2); 6.9904 (1.3); 4.7230 (2.5); 4.7020 (2.4); 4.1375 (1.6); 4.1260 (2.9); 4.1137 (1.6); 3.8988 (5.7); 3.1409 (1.6); 3.1294 (2.7); 3.1183 (1.5); 3.1130 (1.4); 3.0684 (1.2); 3.0492 (1.3); 3.0304 (1.4); 3.0118 (1.4); 2.8254 (1.4); 2.8073 (4.2); 2.7893 (4.3); 2.7713 (1.4); 2.5113 (0.9); 2.4887 (1.3); 2.4750 (0.7); 2.4519 (1.2); 2.4065 (0.6); 2.3876 (0.8); 2.3673 (1.1); 2.3500 (0.8); 2.2956 (16.0); 1.2770 (12.4); 1.2604 (12.6); 1.2514 (6.1); 1.2334 (12.1); 1.2154 (5.4); 0.0078 (2.0); 0.0002 (57.0); 0.0085 (2.0)
[0902] 1H-NMR
[0903] I-344: .sup.1H-NMR(400.0 MHz, CDCl3):
[0904] =7.5184 (0.8); 7.2595 (151.7); 7.0681 (5.5); 7.0481 (3.3); 7.0055 (2.4); 6.9955 (1.0); 6.9857 (1.3); 4.7411 (2.2); 4.7199 (2.2); 4.0985 (1.8); 4.0858 (3.4); 4.0728 (2.0); 3.8067 (5.9); 3.0590 (2.3); 3.0499 (2.9); 3.0385 (2.7); 3.0197 (1.6); 3.0010 (1.5); 2.6387 (2.6); 2.6203 (3.4); 2.6013 (2.9); 2.5092 (0.9); 2.4862 (1.2); 2.4706 (0.7); 2.4483 (1.1); 2.3487 (0.8); 2.3298 (1.1); 2.3122 (0.9); 2.2940 (16.0); 1.6391 (1.6); 1.6204 (2.8); 1.6018 (2.9); 1.5832 (1.7); 1.2815 (12.2); 1.2649 (12.1); 0.9877 (6.2); 0.9694 (12.8); 0.9509 (5.7); 0.0079 (1.4); 0.0002 (55.8); 0.0083 (2.3)
[0905] I-345: .sup.1H-NMR(400.0 MHz, CDCl3):
[0906] =7.8361 (1.7); 7.5186 (2.0); 7.3920 (4.5); 7.3751 (5.5); 7.3716 (4.6); 7.2597 (336.0); 7.2474 (2.4); 7.2387 (6.6); 7.2351 (9.7); 7.2308 (7.9); 7.2293 (7.9); 7.2235 (11.4); 7.2201 (8.6); 7.2133 (5.9); 7.2070 (4.9); 7.2022 (3.4); 7.1961 (4.1); 7.1892 (2.7); 7.1803 (1.9); 7.1735 (1.2); 6.9957 (2.0); 5.2283 (1.4); 5.2095 (3.4); 5.1890 (3.5); 5.1700 (1.4); 4.2913 (1.9); 4.2763 (3.4); 4.2613 (3.0); 4.2476 (2.0); 4.1245 (10.4); 4.1095 (16.0); 4.0944 (11.3); 3.2213 (1.7); 3.2065 (1.2); 3.1930 (1.9); 3.1796 (11.9); 3.1714 (4.9); 3.1652 (8.9); 3.1594 (4.8); 3.1513 (12.7); 3.0131 (1.5); 3.0041 (1.7); 2.9910 (1.7); 2.9823 (1.8); 2.9733 (2.9); 2.9645 (3.0); 2.9517 (3.0); 2.9430 (3.0); 2.8858 (2.2); 2.8647 (4.6); 2.8449 (3.7); 2.8252 (2.5); 2.8053 (1.6); 2.7111 (2.2); 2.7022 (2.1); 2.6932 (2.5); 2.6842 (2.5); 2.6795 (2.7); 2.6736 (2.1); 2.6706 (2.5); 2.6646 (2.0); 2.6614 (2.8); 2.6525 (2.7); 2.6420 (1.9); 2.6330 (1.7); 2.4693 (0.6); 2.4544 (1.0); 2.4420 (3.8); 2.4342 (2.3); 2.4271 (6.4); 2.4195 (3.8); 2.4128 (8.6); 2.4069 (3.6); 2.4042 (3.6); 2.3987 (5.4); 2.3837 (2.8); 1.8898 (2.1); 1.8685 (4.4); 1.8581 (2.1); 1.8496 (4.3); 1.8472 (2.6); 1.8392 (2.5); 1.8368 (4.0); 1.8282 (2.0); 1.8179 (4.0); 1.7965 (1.8); 1.5646 (17.8); 1.3331 (1.0); 1.2845 (1.6); 1.2563 (2.1); 0.0079 (4.2); 0.0002 (129.4); 0.0085 (3.9)
[0907] I-346: .sup.1H-NMR(400.0 MHz, CDCl3):
[0908] =7.5193 (1.4); 7.3662 (12.4); 7.3487 (15.5); 7.3116 (0.5); 7.2937 (0.8); 7.2603 (239.3); 7.2536 (26.1); 7.2507 (27.3); 7.2447 (20.7); 7.2393 (25.8); 7.2358 (21.0); 7.2216 (12.5); 7.2175 (9.9); 7.2060 (7.1); 7.2026 (7.1); 7.1870 (3.4); 6.9963 (1.3); 5.2691 (5.1); 5.2609 (5.2); 5.2510 (10.3); 5.2429 (9.8); 5.2330 (5.3); 5.2249 (4.8); 4.3891 (5.4); 4.3831 (6.6); 4.3773 (5.6); 4.3709 (2.9); 4.3610 (3.4); 4.3548 (7.0); 4.3490 (7.7); 4.3429 (6.1); 4.3362 (4.0); 4.1299 (3.1); 4.1193 (4.5); 4.1109 (3.2); 4.1004 (5.2); 4.0937 (5.3); 4.0892 (6.2); 4.0706 (2.8); 4.0663 (2.7); 4.0595 (3.2); 3.4885 (6.9); 3.4196 (1.1); 3.3950 (6.0); 3.3801 (10.3); 3.3652 (7.2); 3.3497 (8.9); 3.3225 (0.9); 3.1355 (1.8); 3.1232 (1.8); 3.1022 (4.7); 3.0905 (5.8); 3.0744 (15.1); 3.0695 (16.0); 3.0574 (5.5); 3.0453 (15.6); 3.0384 (10.1); 3.0302 (4.6); 3.0220 (4.0); 3.0154 (5.5); 3.0092 (5.0); 2.9991 (5.7); 2.9902 (6.6); 2.9824 (5.2); 2.9765 (4.9); 2.9691 (6.9); 2.9611 (4.6); 2.9057 (4.7); 2.8854 (9.5); 2.8654 (7.6); 2.8455 (5.6); 2.8254 (3.5); 2.7130 (2.5); 2.7030 (4.1); 2.6936 (5.2); 2.6838 (6.3); 2.6748 (5.7); 2.6714 (5.6); 2.6619 (6.1); 2.6527 (6.5); 2.6430 (5.3); 2.6334 (3.6); 2.6236 (2.1); 2.3971 (3.3); 2.3896 (4.2); 2.3849 (4.1); 2.3775 (3.9); 2.3742 (3.9); 2.3624 (5.5); 2.3546 (8.4); 2.3414 (2.8); 2.3372 (2.9); 2.3304 (2.0); 2.3196 (1.3); 1.9076 (3.5); 1.8869 (7.7); 1.8756 (3.8); 1.8674 (7.5); 1.8551 (7.3); 1.8468 (3.4); 1.8356 (6.8); 1.8150 (2.7); 0.0071 (3.4); 0.0002 (87.7); 0.0084 (3.3)
[0909] I-347: .sup.1H-NMR(400.0 MHz, CDCl3):
[0910] =7.5182 (0.5); 7.2592 (86.6); 7.1914 (3.5); 7.1291 (2.0); 7.1101 (3.1); 7.0445 (2.3); 7.0252 (1.4); 5.2978 (3.8); 5.1896 (0.5); 5.1705 (1.3); 5.1494 (1.4); 5.1303 (0.6); 4.2520 (1.1); 4.2289 (1.0); 4.1246 (3.8); 4.1096 (5.8); 4.0944 (4.1); 3.1801 (4.2); 3.1718 (1.8); 3.1657 (3.2); 3.1600 (1.7); 3.1518 (4.6); 2.9492 (0.5); 2.9283 (0.6); 2.9188 (0.8); 2.9103 (0.9); 2.8973 (0.9); 2.8891 (0.9); 2.8306 (0.6); 2.8111 (1.3); 2.7911 (1.0); 2.7722 (0.7); 2.6985 (0.8); 2.6900 (0.8); 2.6806 (0.9); 2.6722 (0.9); 2.6672 (0.9); 2.6613 (0.7); 2.6586 (0.9); 2.6527 (0.7); 2.6490 (1.0); 2.6405 (0.9); 2.6299 (0.6); 2.6213 (0.6); 2.4422 (1.2); 2.4273 (2.2); 2.4195 (1.3); 2.4129 (3.2); 2.4069 (1.3); 2.3987 (1.9); 2.3837 (1.0); 2.3248 (16.0); 1.8712 (0.7); 1.8502 (1.6); 1.8399 (0.7); 1.8311 (1.5); 1.8187 (1.4); 1.8098 (0.7); 1.7996 (1.4); 1.7782 (0.6); 1.5764 (1.2); 0.0080 (1.0); 0.0002 (32.0); 0.0085 (0.9)
[0911] 1H-NMR
[0912] I-348: .sup.1H-NMR(400.0 MHz, CDCl3):
[0913] =7.2587 (23.4); 7.1071 (1.6); 7.0653 (0.9); 7.0463 (1.6); 6.9996 (1.2); 6.9806 (0.7); 6.9518 (2.6); 6.8284 (1.0); 6.7868 (1.1); 6.7645 (0.6); 5.2949 (5.8); 4.7791 (0.5); 4.7565 (1.0); 4.7341 (0.6); 4.2015 (0.6); 4.1773 (0.6); 4.1121 (1.9); 4.0971 (2.9); 4.0820 (2.0); 3.8124 (5.1); 3.7013 (16.0); 3.5535 (4.9); 3.1822 (1.8); 3.1776 (0.7); 3.1733 (0.8); 3.1691 (1.2); 3.1671 (1.3); 3.1623 (0.8); 3.1583 (0.7); 3.1539 (2.0); 3.0293 (0.6); 3.0103 (0.6); 2.9910 (0.7); 2.9719 (0.7); 2.4777 (0.5); 2.4409 (1.0); 2.4327 (0.9); 2.4259 (1.1); 2.4208 (0.8); 2.4121 (1.7); 2.4057 (0.8); 2.4029 (0.8); 2.3981 (1.4); 2.3824 (0.6); 2.2948 (7.5); 2.2139 (0.7); 2.1970 (0.6); 2.1933 (0.5); 2.1910 (0.5); 1.5957 (2.4); 1.3097 (5.8); 1.2922 (6.7); 1.2895 (7.8); 1.2727 (7.0); 1.1962 (3.8); 1.1792 (3.7); 1.1500 (0.6); 1.1316 (0.5); 0.9258 (4.1); 0.9175 (0.6); 0.9090 (3.8): -0.0002 (8.6)
[0914] I-349: .sup.1H-NMR(400.0 MHz, CDCl3):
[0915] =7.5183 (0.9); 7.4466 (3.7); 7.4322 (3.8); 7.4238 (4.2); 7.2593 (150.8); 7.1784 (1.1); 7.1659 (5.5); 7.1615 (7.2); 7.1526 (14.4); 7.1437 (9.5); 7.1391 (5.6); 7.1268 (1.2); 7.1047 (0.8); 7.0950 (4.8); 7.0864 (3.9); 7.0726 (2.6); 6.9954 (0.8); 5.2973 (16.0); 4.8531 (1.5); 4.8393 (2.4); 4.8312 (2.0); 4.8183 (2.6); 4.8038 (1.4); 4.2693 (3.0); 4.2481 (2.7); 4.1299 (0.9); 4.1134 (10.4); 4.0985 (15.4); 4.0833 (10.4); 3.1740 (10.2); 3.1699 (3.3); 3.1655 (4.2); 3.1598 (8.1); 3.1539 (4.2); 3.1457 (10.8); 2.8610 (0.7); 2.8460 (1.4); 2.8308 (0.9); 2.8199 (2.0); 2.8044 (3.7); 2.7890 (2.2); 2.7793 (2.2); 2.7628 (3.2); 2.7467 (2.4); 2.7201 (1.0); 2.7049 (0.8); 2.4365 (2.9); 2.4323 (1.2); 2.4216 (5.4); 2.4162 (3.5); 2.4073 (8.1); 2.4012 (3.0); 2.3987 (3.2); 2.3929 (4.7); 2.3781 (2.4); 2.1239 (0.9); 2.1165 (I.I); 2.1113 (0.8); 2.1015 (1.4); 2.0921 (2.2); 2.0809 (2.3); 2.0703 (2.2); 2.0608 (2.0); 2.0483 (1.6); 2.0430 (3.3); 1.9563 (1.1); 1.9487 (1.4); 1.9405 (1.6); 1.9348 (2.6); 1.9285 (2.4); 1.9159 (2.6); 1.9032 (3.0); 1.8935 (2.2); 1.8864 (3.2); 1.8815 (2.4); 1.8712 (1.5); 1.8668 (1.9); 1.8589 (1.6); 1.8521 (1.7); 1.8434 (2.0); 1.8347 (2.0); 1.8270 (1.6); 1.8186 (1.8); 1.8066 (1.3); 1.7983 (1.3); 1.7854 (0.7); 1.5851 (2.9); 1.2762 (0.9); 1.2582 (2.1); 1.2403 (0.9); 0.0079 (2.0); 0.0002 (53.4); 0.0084 (1.4)
[0916] I-350: .sup.1H-NMR(400.0 MHz, CDCl3):
[0917] =7.4373 (0.6); 7.4193 (0.8); 7.4098 (1.7); 7.4035 (1.0); 7.4011 (0.9); 7.3957 (1.8); 7.3870 (1.9); 7.2595 (68.2); 7.1493 (1.0); 7.1443 (0.9); 7.1374 (2.7); 7.1326 (3.8); 7.1249 (7.1); 7.1155 (4.4); 7.1114 (3.3); 7.0994 (0.6); 7.0843 (0.9); 7.0799 (0.9); 7.0681 (2.6); 7.0612 (1.8); 7.0590 (1.9); 7.0514 (0.8); 7.0457 (1.2); 5.2969 (16.0); 4.5130 (1.1); 4.4910 (2.0); 4.4697 (1.3); 4.2004 (1.6); 4.1770 (1.4); 4.1662 (0.7); 4.1298 (0.5); 4.1120 (0.6); 4.0988 (5.1); 4.0839 (8.0); 4.0687 (5.2); 3.1749 (4.9); 3.1664 (2.4); 3.1601 (4.4); 3.1549 (2.4); 3.1509 (2.1); 3.1467 (5.6); 2.8403 (0.8); 2.8316 (1.2); 2.8179 (2.3); 2.8037 (2.5); 2.7964 (1.6); 2.7899 (1.8); 2.7755 (0.5); 2.4356 (1.6); 2.4312 (0.7); 2.4274 (1.0); 2.4206 (3.1); 2.4152 (2.1); 2.4063 (4.8); 2.4001 (1.9); 2.3977 (2.0); 2.3920 (2.9); 2.3818 (0.7); 2.3772 (1.5); 2.0428 (2.0); 1.9959 (0.5); 1.9881 (0.7); 1.9821 (1.1); 1.9743 (1.3); 1.9683 (0.6); 1.9604 (1.0); 1.9554 (1.0); 1.9494 (0.9); 1.9419 (2.1); 1.9292 (1.4); 1.9160 (0.7); 1.9099 (0.8); 1.9070 (0.9); 1.9032 (1.0); 1.8993 (0.7); 1.8956 (0.6); 1.8866 (0.8); 1.8789 (0.6); 1.6776 (0.7); 1.6619 (0.8); 1.6547 (1.2); 1.6444 (1.0); 1.6387 (1.3); 1.6327 (1.2); 1.6290 (1.3); 1.6221 (1.6); 1.6168 (1.9); 1.6071 (1.6); 1.6004 (0.9); 1.2759 (0.7); 1.2581 (1.5); 1.2402 (0.6); 1.1200 (14.5); 1.1033 (14.5); 1.0383 (5.1); 1.0212 (5.0); 0.0080 (0.7); 0.0002 (25.5); 0.0085 (0.8)
[0918] I-352: .sup.1H-NMR(400.0 MHz, CDCl3):
[0919] =7.5184 (1.0); 7.3871 (5.4); 7.3696 (6.6); 7.3662 (5.3); 7.2596 (175.0); 7.2484 (2.2); 7.2392 (8.2); 7.2358 (11.3); 7.2317 (9.5); 7.2242 (12.1); 7.2206 (9.8); 7.2127 (6.5); 7.2073 (5.3); 7.2027 (4.3); 7.1966 (4.6); 7.1889 (3.1); 7.1797 (2.0); 7.1730 (1.2); 6.9956 (1.0); 5.2976 (13.7); 5.2384 (1.8); 5.2194 (4.3); 5.1984 (4.4); 5.1795 (1.9); 4.2720 (14.9); 4.2598 (8.5); 4.2582 (8.3); 4.2460 (16.0); 4.2156 (3.1); 3.0143 (1.8); 3.0053 (2.0); 2.9926 (1.9); 2.9836 (2.1); 2.9747 (3.3); 2.9656 (3.5); 2.9531 (3.4); 2.9443 (3.5); 2.8853 (2.6); 2.8646 (6.1); 2.8579 (14.2); 2.8516 (6.3); 2.8445 (13.5); 2.8361 (6.2); 2.8301 (15.4); 2.8051 (1.9); 2.7107 (2.4); 2.7016 (2.3); 2.6926 (3.0); 2.6836 (3.0); 2.6790 (3.0); 2.6731 (2.4); 2.6699 (2.8); 2.6640 (2.4); 2.6609 (3.4); 2.6519 (3.2); 2.6414 (2.2); 2.6324 (1.9); 2.2150 (3.0); 2.2090 (2.6); 2.2003 (5.6); 2.1932 (4.6); 2.1862 (8.6); 2.1797 (4.8); 2.1720 (6.0); 2.1641 (2.9); 2.1578 (3.3); 2.0432 (1.8); 1.8886 (5.8); 1.8809 (2.3); 1.8739 (6.6); 1.8704 (6.9); 1.8674 (8.9); 1.8618 (7.9); 1.8487 (9.7); 1.8359 (6.6); 1.8276 (2.6); 1.8172 (4.5); 1.7958 (2.0); 1.6003 (1.9); 1.2762 (0.7); 1.2583 (1.6); 1.2404 (0.6): 0.8818 (0.8): 0.0079 (2.2): 0.0002 (65.6): -00085 (L9)
[0920] 1H-NMR
[0921] I-353: .sup.1H-NMR(400.0 MHz, CDCl3):
[0922] =7.2592 (57.8); 7.1859 (3.5); 7.1307 (2.0); 7.1116 (3.0); 7.0451 (2.3); 7.0261 (1.4); 5.2974 (2.5); 5.1990 (0.6); 5.1799 (1.3); 5.1589 (1.4); 5.1400 (0.6); 4.2733 (4.5); 4.2612 (2.5); 4.2595 (2.6); 4.2474 (4.7); 4.2144 (1.2); 4.1918 (1.2); 2.9514 (0.5); 2.9294 (0.6); 2.9210 (0.8); 2.9123 (0.9); 2.8995 (0.9); 2.8910 (0.9); 2.8582 (4.2); 2.8519 (1.9); 2.8444 (2.8); 2.8363 (2.1); 2.8304 (5.2); 2.8111 (1.3); 2.7911 (1.0); 2.7719 (0.7); 2.6987 (0.8); 2.6901 (0.8); 2.6809 (0.9); 2.6722 (0.9); 2.6674 (1.0); 2.6615 (0.7); 2.6586 (0.9); 2.6527 (0.7); 2.6494 (1.0); 2.6405 (1.0); 2.6300 (0.6); 2.6212 (0.6); 2.3233 (16.0); 2.2148 (0.9); 2.2088 (0.8); 2.2001 (1.7); 2.1930 (1.5); 2.1859 (2.6); 2.1796 (1.5); 2.1718 (1.9); 2.1639 (1.0); 2.1577 (1.0); 1.8879 (1.1); 1.8843 (0.9); 1.8714 (2.2); 1.8658 0.6); 1.8614 (2.3); 1.8500 (2.8); 1.8399 (1.3); 1.8365 (0.9); 1.8315 (2.1); 1.8187 (1.4); 1.8101 (0.7); 1.7998 (1.4); 1.7784 (0.6); 1.5793 (1.3); 0.0079 (0.7); 0.0002 (21.9); 0.0085 (0.7)
[0923] I-354: .sup.1H-NMR(400.0 MHz, CDCl3):
[0924] =7.2593 (60.4); 7.0978 (3.6); 7.0696 (1.8); 7.0505 (3.3); 7.0036 (2.4); 6.9953 (0.6); 6.9847 (1.4); 5.2974 (3.4); 4.7863 (1.1); 4.7642 (1.9); 4.7418 (1.2); 4.2651 (4.3); 4.2532 (2.4); 4.2510 (2.5); 4.2391 (4.4); 4.1587 (1.3); 4.1350 (1.2); 3.0371 (1.2); 3.0180 (1.3); 2.9986 (1.4); 2.9796 (1.5); 2.8663 (4.1); 2.8599 (1.9); 2.8532 (2.6); 2.8446 (1.9); 2.8385 (4.6); 2.4999 (1.0); 2.4766 (1.1); 2.4611 (0.8); 2.4382 (1.0); 2.2938 (16.0); 2.2592 (0.6); 2.2394 (1.0); 2.2198 (1.4); 2.2167 (1.7); 2.2101 (1.0); 2.2008 (2.5); 2.1872 (2.8); 2.1808 (2.0); 2.1738 (1.8); 2.1653 (1.0); 2.1591 (1.0); 1.8896 (1.1); 1.8857 (0.9); 1.8751 (1.9); 1.8676 (1.6); 1.8629 (2.3); 1.8564 (1.6); 1.8488 (1.7); 1.8380 (0.8); 1.8341 (0.9); 1.5933 (0.7); 1.2834 (14.6); 1.2666 (14.3); 0.0080 (0.7); 0.0002 (21.5); 0.0085 (0.6)
[0925] I-355: .sup.1H-NMR(400.0 MHz, CDCl3):
[0926] =7.5184 (0.6); 7.4512 (2.8); 7.4455 (1.8); 7.4401 (1.4); 7.4361 (3.0); 7.4285 (3.2); 7.2595 (106.3); 7.1787 (0.9); 7.1663 (3.7); 7.1618 (6.0); 7.1528 (11.4); 7.1441 (7.5); 7.1388 (4.3); 7.1264 (0.9); 7.1065 (0.5); 7.0964 (3.6); 7.0879 (3.1); 7.0794 (1.5); 7.0739 (2.0); 6.9954 (0.6); 5.2972 (16.0); 4.8612 (1.1); 4.8479 (1.8); 4.8390 (1.5); 4.8264 (1.9); 4.8122 (1.1); 4.2619 (8.6); 4.2499 (4.8); 4.2480 (4.9); 4.2360 (10.8); 4.2134 (2.2); 2.8568 (8.1); 2.8501 (3.8); 2.8434 (5.8); 2.8348 (3.6); 2.8290 (9.1); 2.8204 (1.8); 2.8048 (2.8); 2.7896 (1.6); 2.7801 (1.7); 2.7629 (2.4); 2.7466 (1.8); 2.7204 (0.8); 2.7049 (0.6); 2.2112 (1.6); 2.2051 (1.5); 2.1961 (3.0); 2.1894 (2.6); 2.1822 (4.8); 2.1759 (2.8); 2.1683 (3.2); 2.1603 (1.7); 2.1540 (1.9); 2.1205 (0.7); 2.1127 (0.8); 2.1080 (0.6); 2.0979 (1.0); 2.0888 (1.6); 2.0769 (1.8); 2.0666 (1.7); 2.0574 (1.4); 2.0432 (2.1); 1.9539 (0.8); 1.9470 (1.0); 1.9332 (1.9); 1.9271 (1.8); 1.9161 (2.2); 1.9101 (1.7); 1.9003 (2.4); 1.8930 (2.2); 1.8857 (4.4); 1.8780 (2.9); 1.8715 (4.5); 1.8641 (3.7); 1.8593 (5.0); 1.8525 (3.6); 1.8450 (4.2); 1.8308 (3.0); 1.8165 (1.4); 1.8043 (1.1); 1.7963 (1.0); 1.7827 (0.6); 1.5933 (1.8); 1.2760 (0.6); 1.2582 (1.2); 0.8818 (0.8); 0.0080 (1.2); 0.0002 (38.7); 0.0085 (1.1)
[0927] I-356: .sup.1H-NMR(400.0 MHz, CDCl3):
[0928] =7.4385 (0.8); 7.4216 (0.9); 7.4169 (1.0); 7.4064 (2.1); 7.3913 (2.3); 7.3839 (2.4); 7.2596 (65.7); 7.1529 (0.8); 7.1482 (0.9); 7.1403 (2.9); 7.1353 (4.7); 7.1313 (2.7); 7.1264 (9.9); 7.1180 (5.6); 7.1123 (3.7); 7.0999 (0.8); 7.0944 (0.6); 7.0852 (1.1); 7.0810 (1.3); 7.0711 (3.0); 7.0629 (2.7); 7.0540 (1.2); 7.0488 (1.5); 5.2968 (15.0); 4.9284 (0.6); 4.9168 (0.6); 4.9035 (0.6); 4.8921 (0.6); 4.5156 (1.4); 4.4948 (2.4); 4.4739 (1.6); 4.2460 (7.5); 4.2339 (4.4); 4.2323 (4.4); 4.2202 (7.6); 4.1721 (2.0); 4.1492 (1.8); 4.1332 (0.8); 4.1085 (0.6); 2.8610 (6.1); 2.8575 (4.0); 2.8465 (5.0); 2.8333 (7.1); 2.8299 (3.9); 2.8186 (2.0); 2.8046 (4.4); 2.7898 (3.1); 2.7747 (0.6); 2.2080 (1.7); 2.2019 (1.7); 2.1924 (3.2); 2.1863 (2.9); 2.1790 (4.7); 2.1723 (2.8); 2.1661 (3.0); 2.1572 (1.7); 2.1507 (1.7); 2.0429 (0.7); 2.0004 (0.6); 1.9926 (0.9); 1.9860 (1.4); 1.9780 (1.9); 1.9687 (1.6); 1.9641 (1.6); 1.9605 (1.4); 1.9515 (3.0); 1.9455 (1.7); 1.9361 (2.3); 1.9284 (1.2); 1.9165 (0.9); 1.9088 (0.7); 1.8843 (2.0); 1.8805 (1.7); 1.8701 (3.5); 1.8624 (2.9); 1.8578 (4.5); 1.8512 (3.0); 1.8436 (3.5); 1.8331 (1.6); 1.8290 (1.8); 1.8091 (0.6); 1.8018 (0.5); 1.6738 (1.0); 1.6573 (1.2); 1.6516 (1.3); 1.6403 (1.6); 1.6355 (1.5); 1.6313 (1.3); 1.6243 (1.8); 1.6198 (2.1); 1.6154 (2.3); 1.6041 (1.5); 1.2758 (0.5); 1.2627 (0.8); 1.2581 (0.9); 1.1076 (16.0); 1.0909 (16.0); 1.0301 (6.1): 1.0129 (5.9); 0.8818 (1.2); 0.8642 (0.5); 0.0079 (0.8); 0.0002 (24.2); 0.0085 (0.7)
[0929] 1H-NMR
[0930] I-358: .sup.1H-NMR(400.0 MHz, CDCl3):
[0931] =7.5182 (1.4); 7.3714 (1.2); 7.3536 (1.5); 7.3418 (2.5); 7.3248 (3.1); 7.3192 (2.8); 7.2593 (248.7); 7.1872 (0.5); 7.1790 (0.6); 7.1735 (1.8); 7.1688 (1.5); 7.1610 (2.7); 7.1560 (3.9); 7.1499 (3.8); 7.1450 (6.6); 7.1389 (4.3); 7.1314 (2.6); 7.1265 (3.7); 7.1046 (2.3); 7.0895 (3.4); 7.0844 (3.7); 7.0683 (1.8); 6.9953 (1.4); 4.9680 (0.6); 4.9580 (0.7); 4.9443 (0.7); 4.9340 (0.6); 4.5448 (1.8); 4.5251 (1.5); 4.4978 (1.4); 4.4402 (0.8); 4.4164 (0.7); 4.2442 (2.7); 4.2368 (6.0); 4.2290 (5.0); 4.2220 (9.0); 4.2144 (3.7); 4.2069 (5.8); 3.5370 (6.4); 3.5295 (3.2); 3.5212 (5.6); 3.5069 (7.2); 2.8959 (0.5); 2.8662 (0.8); 2.8524 (1.4); 2.8307 (2.8); 2.8179 (3.5); 2.8090 (2.6); 2.7739 (2.6); 2.7594 (4.2); 2.7520 (3.0); 2.7441 (6.0); 2.7303 (3.9); 2.7139 (1.4); 2.2064 (0.5); 2.1994 (0.6); 2.1886 (0.7); 2.1819 (0.6); 2.0029 (0.6); 1.9949 (1.0); 1.9891 (1.4); 1.9813 (1.8); 1.9677 (1.8); 1.9626 (1.4); 1.9537 (3.2); 1.9397 (2.0); 1.9180 (0.8); 1.9104 (0.6); 1.8133 (0.6); 1.8002 (0.7); 1.7923 (0.6); 1.6824 (0.6); 1.6597 (1.3); 1.6495 (1.3); 1.6432 (1.5); 1.6377 (1.5); 1.6278 (1.7); 1.6216 (1.2); 1.6120 (1.2); 1.5862 (0.6); 1.5425 (9.8); 1.1068 (16.0); 1.0902 (15.9); 1.0376 (8.5); 1.0204 (8.2); 0.0079 (3.2); 0.0002 (92.1); 0.0085 (3.0)
[0932] I-359: .sup.1H-NMR(400.0 MHz, CDCl3):
[0933] =7.5188 (0.5); 7.2599 (93.8); 7.1651 (5.2); 7.1433 (2.7); 7.1242 (4.0); 7.0614 (3.7); 7.0422 (2.4); 6.9958 (0.6); 5.2297 (1.1); 5.2198 (1.0); 5.2114 (2.3); 5.2022 (2.0); 5.1934 (1.3); 5.1843 (1.0); 4.3923 (1.2); 4.3868 (1.5); 4.3828 (1.2); 4.3756 (0.8); 4.3640 (0.8); 4.3534 (2.1); 4.3456 (1.3); 4.3407 (1.2); 4.1374 (0.5); 4.1258 (0.9); 4.1216 (1.0); 4.1153 (0.8); 4.1079 (1.0); 4.1034 (1.3); 4.0975 (1.3); 4.0919 (1.6); 4.0737 (0.8); 4.0692 (0.7); 4.0628 (0.9); 3.4892 (1.0); 3.4118 (0.6); 3.3960 (1.3); 3.3812 (2.1); 3.3734 (1.1); 3.3664 (1.7); 3.3512 (2.0); 3.3414 (0.7); 3.1065 (0.9); 3.0931 (1.0); 3.0777 (3.4); 3.0725 (3.5); 3.0592 (1.4); 3.0477 (3.2); 3.0415 (2.3); 3.0151 (0.8); 2.9751 (0.9); 2.9669 (0.7); 2.9534 (0.9); 2.9446 (1.2); 2.9357 (1.4); 2.9278 (1.1); 2.9143 (1.5); 2.9071 (1.0); 2.8509 (0.9); 2.8308 (1.8); 2.8110 (1.5); 2.7914 (1.1); 2.7715 (0.8); 2.7002 (0.6); 2.6911 (0.6); 2.6874 (0.8); 2.6804 (0.9); 2.6786 (0.9); 2.6731 (0.9); 2.6685 (1.5); 2.6594 (1.5); 2.6557 (1.1); 2.6500 (1.4); 2.6469 (1.1); 2.6411 (1.4); 2.6379 (1.2); 2.6287 (1.1); 2.6218 (0.7); 2.6183 (0.8); 2.6092 (0.6); 2.3983 (0.7); 2.3910 (1.0); 2.3872 (1.0); 2.3802 (0.9); 2.3757 (1.0); 2.3717 (0.9); 2.3629 (1.2); 2.3561 (2.5); 2.3333 (16.0); 2.3027 (0.8); 1.8881 (0.7); 1.8691 (1.7); 1.8565 (0.8); 1.8481 (1.9); 1.8375 (1.7); 1.8295 (0.8); 1.8269 (0.8); 1.8164 (1.7); 1.7976 (0.6); 1.7952 (0.6); 0.0079 (1.0); 0.0002 (35.4); 0.0085 (1.4)
[0934] I-360: .sup.1H-NMR(400.0 MHz, CDCl3):
[0935] =7.5192 (0.5); 7.2603 (96.1); 7.0844 (2.9); 7.0654 (7.8); 7.0225 (4.3); 7.0028 (2.4); 6.9964 (1.2); 4.8195 (2.5); 4.7994 (2.6); 4.3815 (1.2); 4.3758 (1.4); 4.3697 (1.4); 4.3541 (0.8); 4.3469 (1.9); 4.3414 (1.7); 4.3356 (1.6); 4.3291 (1.1); 4.1275 (0.6); 4.1162 (1.3); 4.1052 (1.1); 4.0971 (1.1); 4.0919 (1.3); 4.0864 (1.4); 4.0674 (0.8); 4.0566 (0.8); 3.4898 (7.0); 3.4043 (0.8); 3.3983 (1.2); 3.3899 (1.4); 3.3828 (1.5); 3.3744 (1.3); 3.3685 (1.4); 3.3594 (1.5); 3.3529 (1.7); 3.1149 (0.6); 3.1051 (1.3); 3.0895 (2.0); 3.0830 (3.3); 3.0801 (3.7); 3.0669 (1.5); 3.0574 (4.1); 3.0534 (3.8); 3.0435 (2.0); 3.0338 (1.6); 3.0220 (2.1); 3.0141 (1.6); 3.0025 (1.7); 2.9951 (1.5); 2.5201 (1.8); 2.4975 (2.2); 2.4816 (1.7); 2.4590 (2.0); 2.3972 (1.0); 2.3894 (1.2); 2.3859 (1.0); 2.3819 (1.1); 2.3787 (1.1); 2.3746 (1.0); 2.3577 (2.2); 2.3457 (1.0); 2.3420 (1.1); 2.3310 (0.8); 2.3071 (12.7); 2.2966 (16.0); 2.2815 (2.0); 2.2644 (1.9); 2.2614 (1.9); 2.2482 (1.6); 2.2443 (1.7); 2.2278 (1.1); 2.2087 (0.6); 1.2843 (13.6); 1.2809 (12.3); 1.2675 (13.9); 1.2641 (12.3); 0.0080 (0.9); 0.0002 (35.1); 0.0084 (1.7)
[0936] I-361: .sup.1H-NMR(400.0 MHz, CDCl3):
[0937] =7.5182 (15.3); 7.4013 (10.0); 7.3847 (11.4); 7.3791 (11.2); 7.3208 (4.7); 7.2900 (8.5); 7.2593 (2808.0); 7.2328 (16.6); 7.2241 (10.8); 7.1789 (16.0); 7.1707 (25.9); 7.1629 (18.5); 7.1547 (12.8); 7.1128 (14.1); 7.0901 (8.3); 6.9953 (16.0); 4.8895 (8.0); 4.3790 (4.9); 4.3493 (7.6); 4.1185 (5.3); 4.0900 (6.6); 4.0558 (4.2); 3.3923 (5.4); 3.3782 (8.2); 3.3621 (5.9); 3.3476 (7.0); 3.0930 (4.9); 3.0715 (12.2); 3.0677 (12.5); 3.0401 (9.5); 2.8351 (4.7); 2.8188 (8.3); 2.8037 (6.2); 2.7944 (5.8); 2.7788 (7.9); 2.7619 (6.4); 2.3520 (7.1); 2.0784 (5.5); 2.0680 (5.2); 2.0046 (3.5); 1.9115 (9.2); 1.8921 (9.1); 1.8560 (8.0); 0.1459 (3.4); 0.0080 (32.5); 0.0002 (976.5); 0.0085 (36.2); 0.1494 (4.5)
[0938] 1H-NMR
[0939] I-362: .sup.1H-NMR(400.0 MHz, CDCl3):
[0940] =7.5187 (1.2); 7.3782 (1.3); 7.3585 (1.5); 7.3501 (1.6); 7.3418 (2.7); 7.3348 (2.5); 7.3252 (3.0); 7.3200 (2.4); 7.2597 (200.4); 7.1715 (1.4); 7.1669 (2.1); 7.1590 (1.9); 7.1534 (4.1); 7.1489 (5.1); 7.1433 (5.6); 7.1361 (7.2); 7.1304 (7.2); 7.1125 (3.6); 7.1047 (2.1); 7.0880 (5.1); 7.0830 (4.7); 7.0661 (2.5); 6.9957 (1.1); 4.9619 (1.2); 4.9517 (1.2); 4.5605 (4.1); 4.5404 (4.1); 4.3626 (2.1); 4.3281 (3.2); 4.3171 (2.1); 4.1168 (1.1); 4.1049 (2.0); 4.0942 (1.7); 4.0754 (2.0); 4.0556 (1.1); 4.0449 (1.0); 3.4910 (5.1); 3.3935 (2.1); 3.3784 (2.8); 3.3640 (2.5); 3.3485 (3.1); 3.1017 (1.7); 3.0949 (1.5); 3.0790 (5.5); 3.0741 (5.9); 3.0526 (4.7); 3.0429 (2.8); 3.0201 (1.1); 2.9008 (0.7); 2.8889 (0.7); 2.8726 (1.0); 2.8584 (1.5); 2.8471 (2.4); 2.8329 (3.9); 2.8265 (3.6); 2.8182 (4.8); 2.8044 (3.0); 2.7914 (1.2); 2.7750 (1.3); 2.7314 (0.5); 2.3935 (1.4); 2.3817 (1.5); 2.3746 (1.5); 2.3541 (3.1); 2.3396 (1.3); 2.3274 (0.9); 2.2053 (0.6); 2.1936 (0.6); 2.0078 (0.9); 1.9999 (1.3); 1.9942 (1.9); 1.9864 (2.7); 1.9808 (1.6); 1.9663 (2.6); 1.9548 (3.2); 1.9453 (2.7); 1.9380 (2.0); 1.9284 (1.3); 1.9152 (0.7); 1.8175 (0.5); 1.8039 (0.6); 1.7970 (0.6); 1.6843 (0.8); 1.6625 (1.5); 1.6476 (1.9); 1.6379 (1.7); 1.6313 (1.6); 1.6133 (1.3); 1.5912 (0.5); 1.1095 (15.5); 1.0930 (16.0); 1.0418 (5.3); 1.0350 (3.6); 1.0246 (5.2); 1.0179 (3.3); 0.0079 (2.1); 0.0002 (73.2); 0.0084 (2.8)
[0941] I-364: .sup.1H-NMR(400.0 MHz, CDCl3):
[0942] =7.5186 (1.3); 7.3559 (6.4); 7.3383 (8.5); 7.2596 (231.2); 7.2531 (17.5); 7.2462 (12.2); 7.2422 (15.4); 7.2385 (11.9); 7.2257 (7.6); 7.2196 (5.0); 7.2091 (4.8); 7.2033 (3.1); 7.1946 (2.7); 7.1871 (1.6); 6.9956 (1.3); 5.2429 (4.9); 5.2247 (9.9); 5.2066 (5.0); 4.4746 (14.5); 4.4617 (9.0); 4.4487 (14.9); 3.4915 (16.0); 3.3597 (13.6); 3.3529 (6.4); 3.3450 (10.5); 3.3368 (6.6); 3.3302 (14.5); 3.0328 (2.1); 3.0236 (2.4); 3.0110 (2.4); 3.0020 (2.5); 2.9930 (3.9); 2.9839 (4.2); 2.9712 (4.1); 2.9624 (4.1); 2.9025 (3.0); 2.8820 (6.4); 2.8619 (5.1); 2.8424 (3.7); 2.8219 (2.3); 2.7124 (2.5); 2.7033 (2.5); 2.6934 (3.4); 2.6847 (3.4); 2.6806 (3.3); 2.6747 (2.7); 2.6716 (3.1); 2.6617 (3.8); 2.6530 (3.5); 2.6429 (2.4); 2.6338 (2.1); 2.3992 (3.3); 2.3927 (3.5); 2.3836 (6.2); 2.3762 (5.5); 2.3698 (10.2); 2.3635 (5.7); 2.3553 (6.7); 2.3469 (3.8); 2.3403 (3.8); 2.0314 (3.9); 2.0177 (6.5); 2.0049 (8.2); 1.9906 (6.0); 1.9762 (3.3); 1.8997 (2.4); 1.8785 (5.0); 1.8679 (2.5); 1.8598 (4.9); 1.8467 (4.8); 1.8386 (2.5); 1.8280 (4.6); 1.8067 (2.0); 0.0077 (2.8); 0.0002 (84.2); 0.0084 (2.8)
[0943] I-365: .sup.1H-NMR(400.0 MHz, CDCl3):
[0944] =7.2599 (44.5); 7.1511 (3.7); 7.1250 (3.1); 7.0637 (2.3); 7.0448 (1.4); 5.2051 (1.2); 5.1869 (2.3); 5.1687 (1.2); 4.4740 (3.8); 4.4608 (2.4); 4.4481 (3.9); 3.4901 (5.6); 3.3591 (3.5); 3.3523 (1.7); 3.3443 (2.7); 3.3362 (1.8); 3.3296 (3.8); 2.9462 (0.5); 2.9372 (0.8); 2.9286 (0.9); 2.9156 (0.8); 2.9072 (0.9); 2.8475 (0.6); 2.8270 (1.3); 2.8071 (1.0); 2.7878 (0.7); 2.6995 (0.6); 2.6908 (0.6); 2.6809 (0.8); 2.6724 (0.9); 2.6681 (0.8); 2.6620 (0.7); 2.6592 (0.8); 2.6532 (0.6); 2.6493 (1.0); 2.6407 (0.9); 2.6305 (0.6); 2.6215 (0.5); 2.3986 (0.8); 2.3921 (0.8); 2.3829 (1.5); 2.3755 (1.4); 2.3691 (2.7); 2.3629 (1.5); 2.3547 (1.8); 2.3463 (1.1); 2.3319 (16.0); 2.0293 (1.0); 2.0157 (1.7); 2.0026 (2.2); 1.9885 (1.7); 1.9744 (1.0); 1.8798 (0.6); 1.8588 (1.4); 1.8482 (0.7); 1.8398 (1.3); 1.8272 (1.3); 1.8186 (0.7); 1.8082 (1.2); 1.7868 (0.6); 0.0002 (16.0); 0.0082 (0.8)
[0945] I-366: .sup.1H-NMR(400.0 MHz, CDCl3):
[0946] =7.2596 (56.2); 7.0861 (1.8); 7.0655 (5.7); 7.0279 (2.5); 7.0073 (1.4); 4.7896 (1.8); 4.7692 (1.9); 4.4627 (3.9); 4.4511 (2.5); 4.4483 (2.5); 4.4367 (4.2); 3.4894 (6.5); 3.3680 (3.6); 3.3612 (1.8); 3.3528 (2.7); 3.3452 (1.9); 3.3385 (4.0); 3.0553 (1.2); 3.0362 (1.3); 3.0166 (1.5); 2.9974 (1.5); 2.5158 (1.0); 2.4936 (1.2); 2.4774 (0.9); 2.4557 (1.1); 2.4003 (0.8); 2.3936 (0.9); 2.3841 (1.6); 2.3773 (1.5); 2.3708 (2.7); 2.3644 (1.6); 2.3562 (1.8); 2.3480 (1.2); 2.3413 (1.1); 2.3070 (16.0); 2.2854 (0.9); 2.2656 (1.0); 2.2461 (1.3); 2.2267 (0.9); 2.0303 (1.0); 2.0162 (1.6); 2.0039 (2.2); 1.9907 (1.6); 1.9754 (0.9); 1.2823 (13.8); 1.2655 (13.7); 0.0080 (0.6); 0.0002 (20.7); 0.0085 (1.0)
[0947] 1H-NMR
[0948] I-367: .sup.1H-NMR(400.0 MHz, CDCl3):
[0949] =7.5188 (0.6); 7.4015 (2.3); 7.3848 (3.0); 7.3790 (2.8); 7.2599 (105.8); 7.2501 (1.3); 7.2485 (1.1); 7.2341 (0.6); 7.2023 (0.8); 7.1974 (1.0); 7.1838 (2.9); 7.1793 (3.2); 7.1745 (3.0); 7.1682 (7.6); 7.1613 (4.2); 7.1563 (3.1); 7.1512 (3.3); 7.1381 (1.2); 7.1332 (0.9); 7.1243 (0.7); 7.1112 (3.1); 7.1051 (3.0); 7.0959 (1.6); 7.0930 (1.8); 7.0894 (2.0); 6.9959 (0.7); 4.8739 (1.8); 4.8609 (2.8); 4.8466 (1.8); 4.4652 (6.0); 4.4514 (3.7); 4.4392 (6.4); 3.4907 (16.0); 3.3599 (5.7); 3.3531 (2.8); 3.3452 (4.2); 3.3369 (3.0); 3.3303 (6.4); 2.8605 (0.8); 2.8455 (0.6); 2.8340 (1.2); 2.8181 (2.3); 2.8033 (1.4); 2.7923 (1.5); 2.7756 (2.2); 2.7591 (1.6); 2.7343 (0.8); 2.7178 (0.7); 2.3960 (1.3); 2.3896 (1.4); 2.3802 (2.4); 2.3729 (2.3); 2.3665 (4.2); 2.3602 (2.6); 2.3524 (2.9); 2.3436 (1.9); 2.3370 (1.8); 2.1239 (0.6); 2.1161 (0.7); 2.1112 (0.6); 2.1022 (0.9); 2.0924 (1.4); 2.0818 (1.6); 2.0704 (1.6); 2.0606 (1.3); 2.0485 (1.0); 2.0299 (1.6); 2.0162 (2.8); 2.0034 (3.5); 1.9887 (2.8); 1.9747 (1.7); 1.9537 (0.9); 1.9462 (1.0); 1.9329 (1.7); 1.9261 (1.7); 1.9161 (2.0); 1.9094 (1.7); 1.9058 (1.7); 1.9003 (2.2); 1.8924 (2.0); 1.8849 (2.4); 1.8774 (1.9); 1.8703 (1.6); 1.8664 (2.0); 1.8586 (1.6); 1.8518 (2.1); 1.8435 (2.0); 1.8355 (1.4); 1.8271 (1.5); 1.8154 (1.1); 1.8069 (1.1); 1.7934 (0.7); 0.0079 (1.0); 0.0002 (39.3); 0.0085 (1.7)
[0950] I-368: .sup.1H-NMR(400.0 MHz, CDCl3):
[0951] =7.5186 (0.5); 7.3891 (1.0); 7.3688 (1.2); 7.3549 (2.5); 7.3383 (3.0); 7.3326 (2.9); 7.2596 (87.5); 7.1778 (0.6); 7.1710 (1.3); 7.1664 (1.3); 7.1598 (2.7); 7.1550 (3.2); 7.1489 (3.7); 7.1436 (7.7); 7.1377 (4.0); 7.1313 (2.8); 7.1267 (3.6); 7.1130 (1.1); 7.1033 (1.8); 7.0889 (3.4); 7.0834 (3.6); 7.0673 (1.9); 6.9956 (0.5); 4.9316 (1.2); 4.9207 (1.2); 4.5210 (3.1); 4.5016 (3.1); 4.4528 (2.5); 4.4459 (6.5); 4.4322 (4.8); 4.4272 (4.4); 4.4201 (6.2); 3.4901 (3.0); 3.3656 (5.2); 3.3593 (4.5); 3.3512 (5.1); 3.3434 (4.0); 3.3362 (6.6); 3.3303 (2.8); 2.8692 (0.6); 2.8542 (1.0); 2.8410 (1.8); 2.8299 (2.9); 2.8171 (3.9); 2.8066 (2.8); 2.7900 (0.9); 2.7686 (0.7); 2.3935 (1.6); 2.3871 (1.8); 2.3780 (3.3); 2.3705 (3.0); 2.3642 (5.5); 2.3580 (3.2); 2.3499 (3.8); 2.3412 (2.1); 2.3348 (2.0); 2.2142 (0.6); 2.2033 (0.6); 2.1965 (0.6); 2.0257 (1.9); 2.0123 (3.5); 1.9998 (4.9); 1.9877 (4.6); 1.9805 (4.4); 1.9741 (2.9); 1.9639 (3.3); 1.9528 (2.6); 1.9467 (2.8); 1.9391 (2.1); 1.9315 (1.4); 1.9192 (0.8); 1.8446 (0.5); 1.8367 (0.5); 1.8245 (0.5); 1.8103 (0.6); 1.8028 (0.6); 1.6837 (0.8); 1.6686 (1.1); 1.6606 (1.5); 1.6484 (1.6); 1.6446 (1.7); 1.6390 (1.3); 1.6343 (1.4); 1.6284 (1.5); 1.6236 (1.5); 1.6126 (1.2); 1.6039 (0.8); 1.5883 (0.7); 1.2838 (0.8); 1.2668 (0.7); 1.1022 (15.9); 1.0857 (16.0); 1.0298 (6.6); 1.0126 (6.5); 0.0076 (0.8);-0.0002 (32.2); 0.0083 (1.6)
[0952] I-369: .sup.1H-NMR(400.0 MHz, CDCl3):
[0953] =7.5186 (3.2); 7.3671 (8.9); 7.3498 (11.6); 7.2916 (1.0); 7.2710 (3.4); 7.2702 (3.6); 7.2598 (570.7); 7.2547 (30.3); 7.2532 (30.6); 7.2515 (29.2); 7.2445 (24.4); 7.2394 (27.7); 7.2358 (23.3); 7.2241 (15.2); 7.2172 (11.3); 7.2068 (9.5); 7.2015 (6.9); 7.1921 (5.1); 7.1847 (3.4); 6.9957 (3.2); 5.2264 (5.5); 5.2084 (11.4); 5.1904 (6.1); 4.5918 (5.0); 4.5620 (8.4); 4.5584 (7.9); 4.5286 (7.8); 4.3351 (5.3); 4.3230 (5.2); 4.2989 (4.2); 4.2913 (4.1); 4.2868 (3.9); 3.5122 (5.9); 3.5006 (5.7); 3.4901 (9.0); 3.4807 (5.8); 3.4657 (5.7); 3.4617 (5.0); 3.0336 (3.1); 3.0248 (3.5); 3.0121 (3.5); 3.0032 (3.9); 2.9940 (5.7); 2.9849 (6.2); 2.9726 (6.1); 2.9633 (6.3); 2.9044 (5.8); 2.8834 (16.0); 2.8641 (10.4); 2.8516 (9.2); 2.8457 (9.8); 2.8219 (5.9); 2.7950 (11.9); 2.7632 (13.3); 2.7285 (5.4); 2.7040 (4.0); 2.6947 (3.9); 2.6845 (5.9); 2.6751 (6.0); 2.6725 (6.1); 2.6664 (4.5); 2.6630 (5.1); 2.6526 (6.8); 2.6432 (5.9); 2.6344 (3.9); 2.6250 (3.4); 2.1707 (8.2); 2.1617 (9.0); 2.1540 (8.2); 2.1397 (9.3); 2.1288 (9.9); 2.1236 (9.8); 1.9068 (2.8); 1.9009 (2.0); 1.8857 (5.7); 1.8799 (4.0); 1.8749 (3.5); 1.8673 (7.3); 1.8645 (6.2); 1.8618 (6.7); 1.8568 (6.8); 1.8540 (6.7); 1.8465 (5.4); 1.8403 (4.3); 1.8353 (8.0); 1.8325 (8.3); 1.8268 (9.0); 1.8142 (4.6); 1.8085 (3.2); 1.7971 (6.1); 1.7712 (2.1); 0.1461 (0.7); 0.0079 (6.4); 0.0002 (215.5); 0.0085 (8.7);- 0.1496 (0.8)
[0954] I-370: .sup.1H-NMR(400.0 MHz, CDCl3):
[0955] =7.2597 (88.3); 7.1669 (3.2); 7.1427 (1.8); 7.1237 (2.8); 7.0607 (2.3); 7.0410 (1.5); 6.9957 (0.5); 5.1862 (1.0); 5.1681 (2.2); 5.1504 (I. I); 4.5952 (0.9); 4.5625 (1.4); 4.5591 (1.4); 4.5294 (1.4); 4.3371 (0.9); 4.3247 (0.9); 4.3012 (0.7); 4.2887 (0.7); 3.5103 (1.0); 3.4986 (1.0); 3.4941 (0.9); 3.4896 (1.5); 3.4790 (0.9); 3.4635 (1.0); 3.4596 (0.8); 2.9391 (0.8); 2.9300 (0.9); 2.9168 (1.0); 2.9086 (1.0); 2.8831 (1.0); 2.8517 (1.8); 2.8294 (1.6); 2.8097 (1.4); 2.7930 (2.3); 2.7593 (2.0); 2.7276 (0.8); 2.6905 (0.6); 2.6817 (0.6); 2.6715 (1.0); 2.6622 (0.9); 2.6595 (0.9); 2.6502 (0.8); 2.6398 (1.1); 2.6305 (1.0); 2.6215 (0.6); 2.6123 (0.5); 2.3316 (16.0); 2.1694 (1.4); 2.1601 (1.5); 2.1520 (1.4); 2.1381 (1.6); 2.1277 (1.7); 2.1218 (1.6); 1.8657 (1.1); 1.8607 (1.0); 1.8553 (0.9); 1.8473 (1.0); 1.8425 (1.0); 1.8342 (1.3); 1.8289 (1.5); 1.8261 (1.5); 1.8156 (1.1); 1.8111 (1.0); 1.7944 (1.3); 0.0079 (0.9); 0.0002 (32.5); 0.0085 (1.5)
[0956] 1H-NMR
[0957] I-371: .sup.1H-NMR(400.0 MHz, CDCl3):
[0958] =7.2595 (73.1); 7.0850 (1.6); 7.0653 (5.0); 7.0246 (2.7); 7.0054 (1.3); 4.7683 (2.2); 4.7482 (2.2); 4.5954 (0.7); 4.5604 (1.4); 4.5265 (1.0); 4.3303 (0.9); 4.3215 (0.9); 4.2944 (0.7); 4.2855 (0.7); 3.5234 (1.0); 3.5117 (0.9); 3.4920 (2.0); 3.4766 (0.9); 3.0592 (0.8); 3.0397 (0.9); 3.0203 (1.0); 3.0016 (1.0); 2.8860 (0.8); 2.8555 (1.3); 2.8240 (2.5); 2.7913 (2.0); 2.7582 (0.7); 2.5159 (0.9); 2.4937 (1.1); 2.4774 (0.8); 2.4555 (1.0); 2.3068 (16.0); 2.2677 (0.6); 2.2514 (0.8); 2.2365 (0.6); 2.1776 (1.6); 2.1615 (1.3); 2.1462 (1.7); 2.1314 (1.9); 1.8416 (1.0); 1.8122 (0.8); 1.2845 (6.4); 1.2730 (6.6); 1.2677 (6.8); 1.2562 (6.0); 0.0079 (0.8); 0.0002 (26.6); 0.0080 (1.0)
[0959] I-372: .sup.1H-NMR(400.0 MHz, CDCl3):
[0960] =7.5186 (2.3); 7.4167 (3.5); 7.4071 (5.8); 7.4002 (6.6); 7.3917 (6.9); 7.3844 (5.7); 7.3725 (0.8); 7.2597 (408.8); 7.2014 (1.2); 7.1964 (2.6); 7.1833 (8.2); 7.1781 (11.9); 7.1689 (20.2); 7.1608 (13.8); 7.1543 (8.9); 7.1412 (1.8); 7.1215 (1.1); 7.1107 (9.5); 7.1043 (7.5); 7.0889 (5.6); 6.9956 (2.3); 4.8543 (5.6); 4.8407 (9.4); 4.8269 (5.4); 4.5822 (3.8); 4.5524 (6.5); 4.5184 (5.3); 4.3275 (4.2); 4.3161 (3.9); 4.2914 (3.1); 4.2795 (2.9); 3.5118 (4.8); 3.5005 (4.6); 3.4908 (10.3); 3.4813 (4.9); 3.4771 (4.2); 3.4660 (4.1); 3.4623 (3.8); 2.9103 (1.7); 2.8754 (5.4); 2.8601 (4.2); 2.8480 (7.9); 2.8330 (6.2); 2.8171 (12.1); 2.8056 (14.9); 2.7927 (5.3); 2.7742 (16.0); 2.7593 (5.4); 2.7398 (4.7); 2.7174 (2.0); 2.1699 (7.2); 2.1612 (6.1); 2.1526 (6.3); 2.1382 (7.6); 2.1231 (8.7); 2.1111 (4.1); 2.0980 (2.4); 2.0879 (3.7); 2.0776 (4.5); 2.0662 (4.3); 2.0562 (4.1); 2.0443 (3.1); 2.0356 (1.4); 1.9589 (2.2); 1.9397 (4.7); 1.9243 (5.4); 1.9120 (5.4); 1.9072 (5.4); 1.8914 (6.2); 1.8700 (5.4); 1.8544 (4.9); 1.8354 (7.2); 1.8303 (7.1); 1.8055 (5.1); 1.7734 (1.5); 0.1461 (0.6); 0.0079 (4.9); 0.0002 (150.2); 0.0085 (4.7); 0.1494 (0.6)
[0961] I-373: .sup.1H-NMR(400.0 MHz, CDCl3):
[0962] =7.5185 (2.4); 7.3952 (0.8); 7.3770 (1.4); 7.3632 (2.8); 7.3468 (3.8); 7.3413 (3.6); 7.3344 (2.8); 7.3276 (2.9); 7.3092 (0.6); 7.2934 (0.7); 7.2596 (447.6); 7.2196 (1.6); 7.1831 (1.2); 7.1696 (2.2); 7.1649 (2.2); 7.1589 (4.5); 7.1526 (6.4); 7.1444 (10.7); 7.1365 (7.2); 7.1292 (5.6); 7.1026 (2.5); 7.0882 (5.6); 7.0827 (5.2); 7.0662 (3.2); 6.9956 (2.5); 4.9090 (1.6); 4.8983 (1.7); 4.5715 (3.0); 4.5414 (3.9); 4.5357 (4.2); 4.5072 (9.2); 4.4880 (5.4); 4.3126 (2.8); 4.3032 (2.8); 4.2767 (2.3); 4.2680 (2.3); 3.5125 (2.8); 3.5024 (2.9); 3.4912 (4.1); 3.4825 (2.9); 3.4680 (2.7); 2.9095 (0.9); 2.8779 (3.0); 2.8556 (2.1); 2.8442 (5.2); 2.8177 (12.1); 2.8021 (6.0); 2.7900 (7.0); 2.7563 (2.9); 2.4579 (0.7); 2.1688 (5.5); 2.1529 (4.5); 2.1378 (5.4); 2.1228 (6.3); 1.9932 (2.4); 1.9856 (3.8); 1.9707 (6.0); 1.9546 (5.2); 1.9438 (3.3); 1.9351 (2.8); 1.9271 (1.7); 1.8701 (1.2); 1.8396 (2.9); 1.8099 (2.9); 1.6968 (0.5); 1.6825 (1.2); 1.6605 (2.2); 1.6480 (2.4); 1.6238 (2.2); 1.6106 (1.6); 1.5873 (0.9); 1.1048 (14.0); 1.0954 (14.7); 1.0883 (16.0); 1.0789 (14.7); 1.0358 (5.0); 1.0289 (5.4); 1.0186 (5.0); 1.0118 (5.3); 0.0079 (3.8); 0.0002 (159.9); 0.0085 (7.6); 0.1498 (0.6)
[0963] I-376: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0964] =7.0494 (2.9); 6.9321 (1.5); 6.9270 (1.4); 6.9115 (1.7); 6.9064 (1.6); 6.6436 (3.7); 6.6229 (3.2); 6.2863 (2.0); 6.2645 (2.0); 4.6573 (0.5); 4.6442 (1.1); 4.6324 (0.8); 4.6225 (1.1); 4.6095 (0.5); 4.2103 (0.5); 4.2020 (0.6); 4.1890 (0.5); 4.1819 (1.3); 4.1743 (1.1); 4.1619 (1.1); 4.1536 (1.1); 4.1494 (1.0); 4.1392 (1.1); 4.1330 (I. I); 4.1232 (1.1); 4.1117 (0.4); 4.1050 (0.5); 4.0966 (0.4); 4.0133 (2.2); 3.9987 (3.9); 3.9838 (2.3); 3.9019 (8.1); 3.3256 (156.7); 3.2892 (0.4); 3.2669 (0.3); 3.2283 (2.4); 3.2147 (2.4); 3.2009 (2.5); 2.6748 (0.5); 2.6704 (0.6); 2.6660 (0.5); 2.5407 (0.4); 2.5236 (1.8); 2.5099 (46.2); 2.5059 (91.5); 2.5015 (118.5); 2.4970 (85.6); 2.3328 (0.6); 2.3280 (0.7); 2.3239 (0.6); 2.2859 (0.7); 2.2656 (1.8); 2.2582 (2.2); 2.2452 (1.5); 2.2299 (0.6); 2.1791 (16.0); 2.0368 (0.4); 2.0245 (0.5); 2.0114 (0.7); 2.0021 (0.9); 1.9904 (1.0); 1.9792 (0.8); 1.9688 (0.9); 1.9599 (0.7); 1.9531 (1.0); 1.9451 (1.0); 1.9382 (0.7); 1.9305 (0.6); 1.9183 (0.5); 1.9103 (0.4);-0.0002 (0.5)
[0965] I-377: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0966] =7.0683 (2.9); 7.0646 (2.9); 6.9419 (1.5); 6.9371 (1.4); 6.9212 (1.7); 6.9163 (1.6); 6.6534 (3.7); 6.6327 (3.2); 6.2863 (2.0); 6.2646 (2.0); 4.6590 (0.5); 4.6461 (1.1); 4.6351 (0.9); 4.6245 (1.1); 4.6113 (0.5); 4.2169 (0.4); 4.2094 (0.5); 4.1890 (1.3); 4.1815 (1.2); 4.1656 (3.3); 4.1549 (2.9); 4.1407 (3.7); 4.1316 (1.4); 4.1193 (0.5); 4.1129 (0.6); 4.1041 (0.4); 3.9101 (8.8); 3.3341 (154.4); 3.2752 (0.4); 2.8992 (2.3); 2.8930 (1.8); 2.8858 (2.2); 2.8777 (1.9); 2.8722 (2.4); 2.6829 (0.5); 2.6787 (0.6); 2.5489 (0.5); 2.5140 (89.8); 2.5096 (115.1); 2.5053 (83.0); 2.3409 (0.6); 2.3364 (0.7); 2.3320 (0.5); 2.2737 (0.4); 2.1864 (16.0); 2.0676 (2.1); 2.0590 (1.8); 2.0383 (1.0); 2.0243 (0.8); 2.0144 (0.9); 2.0029 (1.0); 1.9920 (0.8); 1.9817 (0.6); 1.9759 (0.6); 1.9668 (0.7); 1.9603 (1.0); 1.9523 (1.0); 1.9458 (0.7); 1.9385 (0.7): 1.9255 (0.5); 1.9174 (0.4): 1.9111 (0.3); 1.7901 (0.9); 1.7788 (1.6); 1.7671 (2.0); 1.7557 (1.5)
[0967] 1H-NMR
[0968] I-378: .sup.1H-NMR(400.0 MHz, CDCl3):
[0969] =7.2596 (47.0); 7.0884 (2.5); 7.0042 (1.3); 6.9988 (1.2); 6.9833 (1.5); 6.9781 (1.4); 6.7482 (3.6); 6.7274 (3.0); 4.8084 (1.0); 4.2507 (3.4); 4.2358 (5.0); 4.2207 (3.9); 4.2091 (1.0); 4.2020 (1.2); 4.1945 (1.5); 4.1792 (1.2); 4.1720 (1.4); 4.1663 (0.5); 4.1514 (0.6); 3.5419 (2.9); 3.5341 (1.3); 3.5267 (2.2); 3.5192 (1.3); 3.5117 (3.2); 3.4894 (7.0); 2.7786 (0.8); 2.7708 (0.5); 2.7633 (1.6); 2.7568 (1.1); 2.7486 (2.6); 2.7406 (1.1); 2.7334 (1.4); 2.7264 (0.5); 2.7184 (0.7); 2.2498 (16.0); 2.2354 (0.5); 2.2221 (0.8); 2.2127 (0.9); 2.1998 (1.0); 2.1878 (0.8); 2.1782 (0.6); 2.1689 (0.6); 2.1612 (0.8); 2.1556 (1.0); 2.1483 (1.1); 2.1423 (0.7); 2.1345 (0.8); 0.0079 (0.6); 0.0002 (16.6); 0.0083 (0.6)
[0970] I-379: .sup.1H-NMR(400.0 MHz, CDCl3):
[0971] =7.5182 (1.4); 7.2594 (246.2); 7.0985 (3.7); 7.0048 (2.1); 6.9997 (1.9); 6.9956 (1.9); 6.9838 (2.2); 6.9787 (2.1); 6.7506 (4.3); 6.7298 (3.6); 4.8270 (1.4); 4.8150 (2.9); 4.8027 (1.4); 4.3904 (1.1); 4.3850 (1.1); 4.3551 (1.6); 4.3440 (1.2); 4.2535 (0.8); 4.2336 (1.4); 4.2260 (1.9); 4.2207 (1.6); 4.2120 (2.4); 4.2050 (2.1); 4.1904 (1.4); 4.1833 (2.0); 4.1624 (0.6); 4.1549 (0.6); 4.1363 (0.7); 4.1248 (1.0); 4.1067 (1.0); 4.0955 (1.3); 4.0725 (0.7); 4.0621 (0.7); 3.4456 (0.5); 3.4082 (1.1); 3.3932 (1.8); 3.3783 (1.5); 3.3624 (1.6); 3.1047 (0.9); 3.0927 (1.2); 3.0784 (2.7); 3.0741 (2.3); 3.0552 (2.0); 3.0432 (1.3); 2.4083 (0.8); 2.4008 (0.8); 2.3677 (1.6); 2.2788 (2.1); 2.2528 (16.0); 2.2475 (11.2); 2.2258 (1.0); 2.2166 (1.2); 2.2036 (1.3); 2.1927 (1.1); 2.1818 (0.7); 2.1768 (0.8); 2.1683 (1.1); 2.1627 (1.5); 2.1555 (1.6); 2.1421 (1.1); 2.1282 (0.7); 2.1206 (0.7); 0.0080 (3.0); 0.0002 (91.6); 0.0084 (2.7)
[0972] I-380: .sup.1H-NMR(400.0 MHz, CDCl3):
[0973] =7.5189 (0.5); 7.2601 (95.3); 7.1165 (3.2); 7.0024 (2.0); 6.9963 (2.3); 6.9814 (2.2); 6.9765 (2.0); 6.7489 (4.2); 6.7281 (3.6); 4.7778 (1.4); 4.7662 (2.8); 4.7551 (1.5); 4.5915 (0.7); 4.5842 (0.8); 4.5564 (1.6); 4.5499 (1.1); 4.5259 (1.0); 4.5207 (1.1); 4.3287 (1.0); 4.3209 (1.0); 4.3165 (1.0); 4.2978 (0.8); 4.2924 (0.8); 4.2848 (0.8); 4.2803 (0.8); 4.2648 (0.6); 4.2531 (0.9); 4.2362 (2.0); 4.2269 (2.3); 4.2130 (2.2); 4.2084 (1.8); 4.2043 (1.3); 4.1936 (1.2); 4.1861 (1.5); 4.1820 (1.2); 4.1659 (0.5); 4.1614 (0.5); 4.1580 (0.5); 3.5153 (1.1); 3.5041 (1.1); 3.4904 (7.5); 3.4697 (1.1); 3.4448 (0.7); 3.4014 (0.7); 2.8819 (1.1); 2.8510 (1.5); 2.8343 (0.6); 2.8174 (0.8); 2.7955 (1.8); 2.7607 (2.0); 2.7292 (1.0); 2.2774 (1.9); 2.2502 (16.0); 2.2223 (0.8); 2.2127 (1.1); 2.2005 (1.2); 2.1890 (1.4); 2.1670 (2.8); 2.1597 (3.0); 2.1461 (2.7); 2.1336 (2.7); 2.1123 (1.1); 1.8279 (0.8); 1.8193 (0.8); 1.7897 (0.8); 0.0079 (1.2); 0.0002 (35.7); 0.0085 (1.3)
[0974] I-381: .sup.1H-NMR(400.0 MHz, CDCl3):
[0975] =7.2605 (33.2); 7.1050 (2.3); 7.1004 (2.5); 7.0019 (1.3); 6.9966 (1.4); 6.9811 (1.5); 6.9759 (1.4); 6.7479 (3.5); 6.7270 (3.0); 4.8029 (0.9); 4.7908 (1.9); 4.7788 (0.9); 4.4694 (3.0); 4.4566 (1.9); 4.4435 (3.0); 4.2346 (1.1); 4.2253 (1.1); 4.2205 (1.3); 4.2078 (1.4); 4.2000 (1.5); 4.1849 (1.2); 4.1777 (1.4); 4.1718 (0.5); 4.1570 (0.6); 3.4917 (6.5); 3.3611 (2.7); 3.3543 (1.4); 3.3464 (2.1); 3.3383 (1.4); 3.3316 (2.9); 2.4014 (0.7); 2.3948 (0.7); 2.3856 (1.3); 2.3783 (1.2); 2.3719 (2.1); 2.3656 (1.2); 2.3575 (1.4); 2.3489 (0.8); 2.3425 (0.8); 2.2478 (16.0); 2.2261 (0.8); 2.2164 (0.9); 2.2037 (1.0); 2.1920 (0.8); 2.1822 (0.5); 2.1693 (0.6); 2.1617 (0.7); 2.1557 (0.9); 2.1486 (1.1); 2.1426 (0.7); 2.1348 (0.8); 2.0317 (0.8); 2.0180 (1.4); 2.0047 (1.8); 1.9906 (1.3); 1.9767 (0.7); 0.0002 (12.3)
[0976] I-402: .sup.1H-NMR(400.0 MHz, CDCl3):
[0977] =7.5181 (0.6); 7.2592 (123.9); 6.9952 (0.8); 6.9833 (10.5); 6.9805 (9.4); 5.2979 (7.4); 4.8148 (0.6); 4.8024 (0.9); 4.7816 (1.0); 4.7664 (0.6); 4.2678 (4.2); 4.2539 (2.4); 4.2419 (4.3); 4.2190 (1.4); 4.1974 (1.2); 2.8583 (4.0); 2.8522 (1.7); 2.8446 (2.7); 2.8367 (1.7); 2.8305 (4.3); 2.7985 (0.5); 2.7714 (0.7); 2.7562 (1.3); 2.7418 (0.8); 2.7305 (0.8); 2.7137 (1.1); 2.6974 (0.8); 2.3434 (0.6); 2.2744 (16.0); 2.2130 (0.8); 2.2069 (0.8); 2.1977 (1.5); 2.1914 (1.4); 2.1841 (2.4); 2.1777 (1.4); 2.1703 (1.6); 2.1622 (0.9); 2.1557 (1.0); 2.0730 (0.8); 2.0613 (0.9); 2.0511 (0.8); 2.0431 (1.0); 2.0289 (0.6); 1.9289 (0.6); 1.9145 (1.0); 1.9089 (0.9); 1.8948 (1.2); 1.8837 (2.1); 1.8736 (2.4); 1.8665 (2.4); 1.8615 (3.0); 1.8472 (2.2); 1.8323 (1.3); 1.8240 (0.7); 1.8172 (0.7); 1.8095 (0.8); 1.7933 (0.7); 1.7734 (0.6); 1.5695 (0.6); 1.2584 (0.6); 0.0079 (1.2); 0.0002 (42.5); 0.0085 (1.4)
[0978] I-402: .sup.1H-NMR(400.0 MHz, d.sub.6-DMSO):
[0979] =7.1232 (3.3); 6.9393 (8.6); 6.0237 (1.8); 6.0008 (1.9); 5.7526 (16.0); 4.6085 (0.6); 4.5965 (0.9); 4.1460 (2.5); 4.1333 (1.8); 4.1205 (2.6); 3.3075 (36.4); 2.8888 (2.3); 2.8825 (1.6); 2.8752 (2.0); 2.8674 (1.6); 2.8613 (2.5); 2.6849 (0.6); 2.6734 (1.0); 2.6689 (1.4); 2.6645 (1.2); 2.6531 (1.0); 2.6349 (1.1); 2.6202 (0.6); 2.5225 (1.7); 2.5178 (2.3); 2.5091 (28.3); 2.5045 (59.8); 2.4999 (82.8); 2.4953 (57.1); 2.4908 (26.0); 2.3266 (0.6); 2.2099 (14.8); 2.0857 (0.6); 2.0717 (1.3); 2.0647 (1.3); 2.0574 (1.8); 2.0507 (1.4); 2.0440 (1.3); 2.0362 (0.8); 2.0296 (0.6); 1.9074 (0.6); 1.8985 (0.9); 1.8839 (1.6); 1.8724 (1.4); 1.8582 (0.8); 1.7816 (0.8); 1.7697 (1.4); 1.7560 (1.9); 1.7275 (1.3); 1.7085 (0.8); 1.7026 (1.0); 1.6844 (0.8); 1.6703 (0.8); 1.6496 (0.6); 0.0080 (0.6); 0.0002 (19.0); 0.0085 (0.6)
B. FORMULATION EXAMPLES
[0980] a) A dusting product is obtained by mixing 10 parts by weight of a compound of the formula (I) and/or salts thereof and 90 parts by weight of talc as an inert substance and comminuting the mixture in a hammer mill. [0981] b) A readily water-dispersible, wettable powder is obtained by mixing 25 parts by weight of a compound of the formula (I) and/or salts thereof, 64 parts by weight of kaolin-containing quartz as an inert substance, 10 parts by weight of potassium lignosulfonate and 1 part by weight of sodium oleoylmethyltaurate as a wetting agent and dispersant, and grinding the mixture in a pinned-disk mill. [0982] c) A readily water-dispersible dispersion concentrate is obtained by mixing 20 parts by weight of a compound of the formula (I) and/or salts thereof with 6 parts by weight of alkylphenol polyglycol ether (Triton X 207), 3 parts by weight of isotridecanol polyglycol ether (8 EO) and 71 parts by weight of paraffinic mineral oil (boiling range for example about 255 to above 277 C.), and grinding the mixture in a friction ball mill to a fineness of below 5 microns. [0983] d) An emulsifiable concentrate is obtained from 15 parts by weight of a compound of the formula (I) and/or salts thereof, 75 parts by weight of cyclohexanone as a solvent and 10 parts by weight of ethoxylated nonylphenol as an emulsifier. [0984] e) Water-dispersible granules are obtained by mixing [0985] 75 parts by weight of a compound of the formula (I) and/or salts thereof, [0986] 10 parts by weight of calcium lignosulfonate, [0987] 5 parts by weight of sodium lauryl sulfate, [0988] 3 parts by weight of polyvinyl alcohol and [0989] 7 parts by weight of kaolin, [0990] grinding the mixture in a pinned-disk mill, and granulating the powder in a fluidized bed by spray application of water as a granulating liquid. [0991] f) Water-dispersible granules are also obtained by homogenizing and precomminuting, in a colloid mill, [0992] 25 parts by weight of a compound of the formula (I) and/or salts thereof, [0993] 5 parts by weight of sodium 2,2-dinaphthylmethane-6,6-disulfonate [0994] 2 parts by weight of sodium oleoylmethyltaurate, [0995] 1 part by weight of polyvinyl alcohol, [0996] 17 parts by weight of calcium carbonate and [0997] 50 parts by weight of water, [0998] then grinding the mixture in a bead mill and atomizing and drying the resulting suspension in a spray tower by means of a one-phase nozzle.
C. BIOLOGICAL EXAMPLES
[0999] C.1 Pre-Emergence Herbicidal Action and Crop Plant Compatibility
[1000] Seeds of monocotyledonous and dicotyledonous weed plants and crop plants are placed in plastic or organic planting pots and covered with soil. The compounds of the invention, formulated in the form of wettable powders (WP) or as emulsion concentrates (EC), are then applied onto the surface of the covering soil as aqueous suspension or emulsion with addition of 0.5% additive at a water application rate of 6001/ha (converted). After the treatment, the pots are placed in a greenhouse and kept under good growth conditions for the trial plants. After about 3 weeks, the effect of the preparations is scored visually in comparison with untreated controls as percentages. For example, 100% activity=the plants have died, 0% activity=like control plants.
[1001] In the tables below, the following abbreviations are used:
[1002] Undesired plants/weeds:
ABUTH: Abutilon theophrasti ALOMY: Alopecurus myosuroides
AMARE: Amaranthus retroflexus AVEFA: Avena fatua
CYPES: Cyperus esculentus ECHCG: Echinochloa crus-galli
LOLMU: Lolium multiflorum MATIN: Matricaria inodora
PHBPU: Ipomoea purpurea POLCO: Polygonum convolvulus
SETVI: Setaria viridis STEME: Stellaria media
VERPE: Veronica persica VTOTR: Viola tricolor
TABLE-US-00013 TABLE B1 Pre-emergence herbicidal efficacy Herbicidal efficacy against [%] Example Application No.: rate [g/ha] ECHCG LOLRI SETVI ABUTH AMARE MATIN POLCO STEME VIOTR VERPE I-152 320 100 100 100 100 100 100 100 100 100 100 I-163 320 100 80 100 100 100 100 100 100 100 100 I-165 320 100 100 100 100 100 100 100 100 100 100 I-167 320 100 100 100 100 100 100 100 100 100 100 I-171 320 90 100 100 100 100 100 100 100 100 100 I-173 320 100 100 100 100 100 100 100 100 100 100 I-175 320 100 100 100 100 100 100 100 100 100 100 I-180 320 100 100 100 100 100 100 100 100 100 100 I-182 320 90 100 100 100 100 100 100 100 100 100 I-190 320 100 100 100 100 100 100 100 100 100 100 I-191 320 100 100 100 100 100 100 100 100 100 100 I-196 320 100 100 100 100 100 100 100 100 100 100 I-197 320 90 80 100 100 100 100 80 100 100 100 I-198 320 90 100 90 100 100 100 100 100 100 100 I-199 320 100 100 100 100 100 100 100 100 100 100 I-200 320 100 100 100 100 100 100 100 100 100 100 I-213 320 100 100 100 100 100 100 100 100 100 100 I-214 320 100 100 100 100 100 100 100 100 100 100 I-215 320 100 100 100 100 100 100 100 100 100 100 I-227 320 100 100 100 100 100 100 100 100 100 100 I-231 320 100 100 100 100 100 100 100 100 100 100 I-232 320 100 100 100 100 100 100 100 100 100 100 I-234 320 100 100 100 100 100 100 100 100 100 100 I-238 320 80 90 100 100 100 100 100 100 100 100 I-245 320 100 100 100 100 100 100 100 100 100 100 I-246 320 100 100 100 80 100 100 100 100 100 100 I-248 320 100 100 100 100 100 100 100 100 100 100 I-249 320 100 100 100 100 100 100 100 100 100 I-254 320 80 100 100 100 100 100 100 100 100 100 I-256 320 90 80 100 100 100 100 100 100 100 100 I-321 320 100 80 100 100 90 100 100 100 I-347 320 100 100 100 100 100 100 100 100 100 I-348 320 100 80 100 100 100 100 100 100 100 100 I-353 320 100 100 100 100 100 100 100 100 100 100 I-354 320 100 100 100 100 100 100 100 100 100 100 I-355 320 100 80 100 100 100 100 100 100 100 100 I-356 320 100 100 100 100 100 100 100 100 100 I-360 320 90 100 100 100 100 100 100 100 100 100 I-360 320 80 100 100 100 100 100 100 100 100 I-365 320 90 100 100 100 100 100 100 100 100 100 I-366 320 100 100 100 100 100 100 100 100 100 100 I-370 320 100 100 100 100 100 100 100 100 100 100 I-371 320 100 100 100 100 100 100 100 100 100 100 I-376 320 100 100 100 100 100 100 100 100 100 100 I-377 320 100 100 100 100 100 100 100 100 100 100 I-380 320 100 80 100 100 100 100 100 100 100 100 I-381 320 100 100 100 100 100 100 100 100 100 I-402 320 100 100 100 100 100 100 100 100 100 100
TABLE-US-00014 TABLE B2 Pre-emergence herbicidal efficacy Herbicidal efficacy against [%] Example Application No.: rate [g/ha] AMARE MATIN POLCO STEME VIOTR VERPE I-151 320 90 100 100 100 90 I-187 320 100 90 100 100 100 100 I-192 320 100 100 100 100 100 100 I-193 320 100 90 100 100 100 100 I-201 320 100 90 100 100 100 100 I-203 320 100 90 100 100 100 100 I-207 320 100 100 100 100 100 100 I-239 320 100 100 100 100 100 100 I-250 320 100 100 100 100 100 90 I-253 320 100 100 100 100 100 100 I-278 320 100 100 100 100 100 100 I-301 320 100 100 80 100 100 90 I-315 320 80 80 90 100 100 I-316 320 100 100 100 100 100 I-320 320 90 100 100 100 100 I-327 320 100 100 100 100 100 I-329 320 100 100 100 100 100 100 I-333 320 100 100 100 100 100 I-336 320 100 100 100 100 100 I-343 320 100 100 100 100 100 I-349 320 100 100 100 100 100 100 I-361 320 100 100 100 100 100 100 I-362 320 100 100 100 100 100 100 I-364 320 100 100 100 100 100 100 I-368 320 100 100 100 100 100 I-373 320 100 100 100 100 100 100 I-378 320 100 100 100 100 100 100
TABLE-US-00015 TABLE B3 Pre-emergence herbicidal efficacy Herbicidal efficacy against [%] Example Application No.: rate [g/ha] MATIN STEME VIOTR I-060 320 100 100 90 I-061 320 100 100 100 I-068 320 100 100 100 I-076 320 90 100 I-078 320 70 90 100 I-087 320 100 100 100 I-094 320 100 100 100 I-097 320 100 100 100 I-157 320 80 100 100 I-158 320 90 100 100 I-160 320 90 100 100 I-164 320 90 100 100 I-166 320 90 100 100 I-168 320 80 90 100 I-169 320 90 100 100 I-170 320 90 100 100 I-172 320 90 100 100 I-174 320 90 100 100 I-176 320 80 80 90 I-177 320 90 100 100 I-178 320 70 100 100 I-179 320 90 100 70 I-181 320 100 100 100 I-183 320 90 100 90 I-184 320 90 100 100 I-185 320 90 100 100 I-186 320 80 100 100 I-194 320 90 100 100 I-195 320 90 100 100 I-202 320 90 100 100 I-204 320 100 100 I-209 320 100 100 100 I-211 320 100 100 100 I-212 320 100 100 100 I-216 320 100 100 100 I-219 320 100 100 100 I-223 320 90 100 90 I-228 320 100 100 100 I-236 320 100 100 100 I-242 320 100 80 I-247 320 100 100 100 I-250 320 100 100 100 I-252 320 100 100 I-253 320 100 100 100 I-255 320 90 100 I-262 320 100 100 I-271 320 90 90 90 I-273 320 80 100 100 I-278 320 80 80 90 I-305 320 100 100 100 I-316 320 100 100 100 I-321 320 100 100 100 I-325 320 100 I-327 320 100 100 100
[1003] As the results show, compounds according to the invention, for example compound Nos. I-231, I-199 and other compounds from table B1, when applied pre-emergence, have very good herbicidal efficacy against harmful plants. Here, for example, compound Nos. I-214 and I-196, when applied pre-emergence, have very good activity (80% to 100% herbicidal activity) against harmful plants such as Abutilon theophrasti, Amaranthus retroflexus, Echinochloa crus-galli, Lolium rigidum, Matricaria inodora, Polygonum convolvulus, Setaria viridis, Stellaria media, Veronica persica and Viola tricolor at an application rate of 0.32 kg of active substance or less per hectare. At the same time, some of the compounds according to the invention leave Gramineae crops such as barley, wheat, rye, millet/sorghum, corn, rice or sugar cane virtually undamaged when applied pre-emergence, even at high active compound dosages. In addition, some substances are also harmless to dicotyledonous crops such as soya, cotton, oilseed rape or sugar beet.
[1004] Some of the compounds according to the invention exhibit high selectivity and are therefore suitable for controlling unwanted vegetation in agricultural crops by the pre-emergence method.
[1005] C.2 Post-Emergence Herbicidal Action and Crop Plant Compatibility
[1006] Seeds of monocotyledonous and dicotyledonous weeds and crop plants are placed in sandy loam in plastic or organic planting pots, covered with soil and cultivated in a greenhouse under controlled growth conditions. 2 to 3 weeks after sowing, the test plants are treated at the one-leaf stage. The compounds of the invention, formulated in the form of wettable powders (WP) or as emulsion concentrates (EC), are then sprayed onto the green parts of the plants as aqueous suspension or emulsion with addition of 0.5% additive at a water application rate of 6001/ha (converted). After the test plants had been kept in the greenhouse under optimum growth conditions for about 3 weeks, the activity of the preparations is rated visually in comparison to untreated controls. For example, 100% activity=the plants have died, 0% activity=like control plants.
TABLE-US-00016 TABLE B4 Post-emergence herbicidal efficacy Herbicidal efficacy against [%] Example Application No.: rate [g/ha] VIOTR VERPE I-068 1280 80 90 I-087 1280 80 90 I-195 1280 90 90 I-219 1280 80 90 I-247 1280 80 80 I-249 1280 80 80 I-273 1280 90 100
TABLE-US-00017 TABLE B5 Post-emergence herbicidal efficacy Herbicidal efficacy against [%] Example Application No.: rate [g/ha] ECHCG LOLRI AMARE STEME VIOTR VERPE I-231 320 100 80 80 80 90 90 I-232 320 80 90 100 100 90 90 I-248 320 100 100 90 100 90 90 I-353 320 100 100 90 100 80 90 I-354 320 100 100 80 100 80 100 I-355 320 100 80 100 80 80 I-366 320 100 90 80 90 I-402 320 100 90 90 90 90
TABLE-US-00018 TABLE B6 Post-emergence herbicidal efficacy Herbicidal efficacy against [%] Example Application No.: rate [g/ha] SETVI ABUTH AMARE VERPE I-180 320 80 80 80 80 I-214 320 100 80 80 100 I-377 320 90 80 80 90
TABLE-US-00019 TABLE B7 Post-emergence herbicidal efficacy Herbicidal efficacy against [%] Example Application No.: rate [g/ha] VIOTR VERPE I-087 320 80 80 I-163 320 80 90 I-165 320 80 90 I-170 320 80 90 I-173 320 80 90 I-190 320 80 80 I-192 320 80 80 I-194 320 80 100 I-195 320 80 80 I-198 320 80 90 I-200 320 80 100 I-202 320 80 80 I-213 320 90 90 I-227 320 90 100 I-234 320 90 80 I-245 320 80 90 I-327 320 80 90
[1007] As the results show, compounds according to the invention, for example compound Nos. I-248, I-353 and I-231 and other compounds from table B5, when applied post-emergence, have very good herbicidal efficacy against harmful plants. Here, for example, compound Nos. I-377 and I-214, when applied post-emergence, have very good herbicidal activity (80% to 100% herbicidal activity) against harmful plants such as Abutilon theophrasti, Amaranthus retroflexus, Setaria viridis, and Veronica persica at an application rate of 0.32 kg of active substance or less per hectare. At the same time, some of the compounds according to the invention leave Gramineae crops such as barley, wheat, rye, millet/sorghum, corn, rice or sugar cane virtually undamaged when applied post-emergence, even at high active compound dosages. In addition, some substances are also harmless to dicotyledonous crops such as soya, cotton, oilseed rape or sugar beet. Some of the compounds according to the invention have high selectivity and are therefore suitable for controlling unwanted vegetation in agricultural crops by the post-emergence method.