MEDICAL VESSELS WITH VALVES AND VALVE LOCK-UNLOCK MECHANISMS
20200315918 ยท 2020-10-08
Inventors
Cpc classification
A61M39/18
HUMAN NECESSITIES
A61J1/2051
HUMAN NECESSITIES
A61M2005/31518
HUMAN NECESSITIES
A61J1/2089
HUMAN NECESSITIES
A61M5/24
HUMAN NECESSITIES
A61M39/16
HUMAN NECESSITIES
A61J1/2096
HUMAN NECESSITIES
A61M5/31511
HUMAN NECESSITIES
A61M2039/242
HUMAN NECESSITIES
A61M5/2459
HUMAN NECESSITIES
A61M5/001
HUMAN NECESSITIES
A61M5/286
HUMAN NECESSITIES
International classification
Abstract
The present invention relates, in some embodiments thereof, to devices, systems and methods for establishing a fluid passageway between vessels. In some embodiments, the invention provides a system for the engagement and establishment of fluid passageway between vessels, the system comprises a first vessel comprising a valve; and a second vessel configured to be coupled to the first vessel; wherein the second vessel comprises a valve unlock mechanism configured to unlock/open the valve, and wherein at about the time of or following the engagement between the first and second vessels, the valve unlock mechanism unlocks/opens the valve, allowing a fluid transfer between the vessels.
Claims
1. A system for the engagement and establishment of fluid passageway between vessels, the system comprising: a first vessel comprising a valve; and a second vessel configured to be coupled to the first vessel; wherein the second vessel comprises a valve unlock mechanism configured to unlock/open the valve, and wherein at about the time of or following the engagement between the first and second vessels, the valve unlock mechanism unlocks/opens the valve, allowing a fluid transfer between the vessels.
2. The system of claim 1, wherein the valve is a one-way valve or a two-way valve.
3. The system of claim 1, wherein the valve is selected from a ball valve, a butterfly valve, choke valve, diaphragm valve, a gate valve, a knife valve, a needle valve, a pinch valve, a piston valve, a plug valve, a solenoid valve, a spool valve, and a combination thereof.
4. The system of claim 1, further comprising a valve lock mechanism configured to lock the valve in a closed position and prevent the premature fluid transfer from the first vessel to the second vessel prior to an engagement with the second vessel.
5. The system of claim 4, wherein the valve lock mechanism is selected from a group consisting of a latch, a spring, a magnet, a hook, a tooth, a pin, a retractable pin, a ratchet tooth, a knob, a retractable knob, a ball, a retractable ball, a thread, a bangle, a locking key, a zip-tie, a moveable wall, and a combination thereof.
6. The system of claim 1, wherein the valve unlock mechanism is selected from a group consisting of a latch, a spring, a magnet, a hook, a tooth, a pin, a retractable pin, a ratchet tooth, a knob, a retractable knob, a ball, a retractable ball, a thread, a bangle, a locking key, a zip-tie, a moveable wall, a hole, a dent, a socket, a channel, an elongated arm, a latch, a lock, a slot, and a combination thereof.
7. The system of claim 1, wherein the valve is pivotally connected to a side wall of the first and/or second vessel and moveable about said pivot.
8. The system of claim 1, wherein the valve lock and/or unlock mechanism is pivotally connected to a side wall of the first and/or second vessel and moveable about said pivot.
9. The system of claim 1, wherein the valve lock and/or unlock mechanism is spring loaded or attached to a spring, allowing planar movement thereof.
10. The system of claim 1, further comprising an engagement mechanism to connect the first vessel to the second vessel, wherein the engagement mechanism is selected from a thread, a luer, a ratchet teeth mechanism, a retention member, an adhesive mechanism, a clamping member and combinations thereof.
11. The system of claim 1, further comprising a piercing member to pierce a seal/cover of the first and/or second vessel(s).
12. The system of claim 11, further comprising a piercing member lock mechanism to prevent premature seal/cover piercing of the first vessel and/or second vessel, by the piercing member.
13. The system of claim 1, further comprising a plunger disposed on the first and/or second vessel(s), the plunger configured to allow for the fluid transfer from the first vessel into the second vessel.
14. The system of claim 13, further comprising a plunger lock mechanism configured to lock a plunger and prevent fluid transfer from the first vessel to the second vessel prior to an engagement with the second vessel.
15. The system of claim 1, wherein the second vessel includes a port having peripheral walls enclosing a cavity, the cavity configured to receive or engage with the first vessel, or a portion thereof.
16. The system of claim 1, further comprising a decontamination device configured to be coupled to the first vessel and second vessel and allow the fluid passageway therebetween, the decontamination device further configured to decontaminate a surface of at least one of the first and second vessels.
17. The system of claim 16, wherein the decontamination device includes a wiping member configured to wipe off a surface of a vessel, wherein the wiping member is configured to move within the device such to allow decontamination a surface of at least one of said first and second vessels at about the time of said wiping member's movement.
18. The system of claim 17, wherein the first and/or second vessel is configured to move within the device and wherein the wiping member configured to remove contaminants from a surface of said first and/or second vessels at about the time of said vessel's movement.
19. The system of claim 17, wherein the decontamination device includes a sliding mechanism located on and/or attached to said wiping member and/or said vessel and configured to allow for the movement of said wiping member and/or said vessel within said device.
20. The system of claim 19, further comprising a valve lock mechanism configured to lock the valve in a closed position and prevent the premature fluid transfer from the first vessel to the second vessel prior to an engagement with the second and wherein the valve unlock mechanism disposed on the decontamination device and/or on the first vessel.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
[0110] Some embodiments of the invention are herein described, by way of example only, with reference to the accompanying drawings. With specific reference now to the drawings in detail, it is stressed that the particulars shown are by way of example and for purposes of illustrative discussion of embodiments of the invention. In this regard, the description taken with the drawings makes apparent to those skilled in the art how embodiments of the invention may be practiced.
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[0146] It should be appreciated that for simplicity and clarity of illustration, elements shown in the figures have not necessarily been drawn to scale. For example, the dimensions of some of the elements are exaggerated relative to each other for clarity. Further, where considered appropriate, reference numerals have been repeated among the figures to indicate corresponding elements.
DETAILED DESCRIPTION OF THE INVENTION
[0147] It is understood that the invention is not limited to the particular methodology, devices, items or products etc., described herein, as these may vary as the skilled artisan will recognize. It is also to be understood that the terminology used herein is used for the purpose of describing particular embodiments only and is not intended to limit the scope of the invention. The following exemplary embodiments may be described in the context of exemplary valve lock and unlock mechanisms for ease of description and understanding. However, the invention is not limited to the specifically described products and methods and may be adapted to various applications without departing from the overall scope of the invention. All ranges disclosed herein include the endpoints. The use of the term or shall be construed to mean and/or unless the specific context indicates otherwise.
[0148] The present invention pertains to devices, methods and systems for fluid transfer between one or more vessels in a secure manner. The present invention pertains to systems, devices, and methods for preventing the premature spillage of beneficial substances/medicaments from containers intended for use in a modular assembly format. The invention provides a solution to an unmet and long felt need in the medical settings and provides vessels with one or more valves and valve lock, and optionally unlock mechanisms, thereby preventing spillage of medical substances. In one or more embodiments, the herein disclosed devices and systems pertain to valve locking and unlocking mechanisms for fluid transfer between vessels. In one or more embodiments, the herein disclosed devices and systems pertain to valve locking and unlocking mechanisms for securing and monitoring a fluid transfer between vessels.
[0149] Thus, it is an object of the present invention, in some embodiments, to provide systems, devices, and methods for establishing fluidic communications between containers. It is an object of the present invention, in some embodiments, to provide vessels having one or more valves for fluid transfer monitoring. It is an object of the present invention, in some embodiments, to provide vessels having at least one valve locking mechanisms. It is an object of the present invention, in some embodiments, to provide vessels having at least one valve unlocking mechanisms. It is an object of the present invention, in some embodiments, to provide systems, devices, and methods of preventing spillage of beneficial substances/medicaments prior to the engagement of at least two vessels.
[0150] The present invention pertains to a system with at least two containers/vessels for establishing a fluidic communication therebetween at about the time, at the time, and/or following an engagement/coupling of the at least two containers/vessels. In some embodiments, at least one of the containers/vessels is having a valve configured to be opened by a second container/vessel, wherein upon opening of the valve a fluidic communication can be established between the containers/vessels.
[0151] In one or more embodiments, engaging/coupling the vessels mediates the unlocking/opening of valves, allowing for a fluidic communication between the vessels. Advantageously, the invention provides systems capable of preventing premature leakage of contents of the containers into the environment. Hence, the system prevents exposure of healthcare personnel to optionally toxic substances which may be contained within the vessels, providing safe means of establishing fluidic communication between at least two containers.
[0152] The valve is configured to be operable in at least two positions, a first closed position which prevents the flow of a substance into and/or out of the vessel, and a second open position which allows the flow of a substance into and/or out of the vessel.
[0153] Thus, in one or more embodiments, the invention provides a system for establishing fluidic communication between vessels, the system comprising: [0154] a first vessel having a valve; and [0155] a second vessel; [0156] wherein upon the engagement between the first and second vessels, the valve is opened allowing a fluid communication between the vessels.
[0157] In one or more embodiments, the invention provides a system for establishing fluidic communication between vessels, the system comprising: [0158] a first vessel having a valve and a valve lock mechanism; and [0159] a second vessel; [0160] wherein upon the engagement between the first and second vessels, the valve lock mechanism is opened allowing opening of the valve and a fluid communication between the vessels.
[0161] In one or more embodiments, the invention provides a system for establishing fluidic communication between vessels, the system comprising: [0162] a first vessel having a valve and a valve lock mechanism; and [0163] a second vessel; [0164] wherein the first and/or second vessel includes a valve unlock mechanism, wherein upon the engagement between the first and second vessels, the valve unlock mechanism unlocks the valve lock mechanism, allowing opening of the valve and a fluid communication between the vessels.
[0165] In one or more embodiments, the invention provides a system for establishing fluidic communication between vessels, the system comprising: [0166] a first vessel having a valve; [0167] a second vessel; and [0168] a decontamination device configured to be coupled to the first and second vessels, the decontamination device allowing a fluid communication between the vessels and decontaminating a surface of the first and/or second vessels; [0169] wherein upon the engagement between the first vessel and the decontamination device, the valve is opened allowing the fluid communication between the vessels.
[0170] In one or more embodiments, the invention provides a system for establishing fluidic communication between vessels, the system comprising: [0171] a first vessel having a valve and a valve lock mechanism; [0172] a second vessel; and [0173] a decontamination device configured to be coupled to the first and second vessels, the decontamination device allowing a fluid communication between the vessels and decontaminating a surface of the first and/or second vessels; [0174] wherein upon the engagement between the first vessel and the decontamination device, the valve lock mechanism is unlocked allowing opening of the valve and a fluid communication between the vessels.
[0175] In one or more embodiments, the invention provides a system for establishing fluidic communication between vessels, the system comprising: [0176] a first vessel having a valve and a valve lock mechanism; [0177] a second vessel; and [0178] a decontamination device configured to be coupled to the first and second vessels, allow a fluid communication between the vessels and decontaminate a surface of the first and/or second vessels; [0179] wherein the first vessel and/or decontamination device include(s) a valve unlock mechanism, wherein upon the engagement between the first vessel and the decontamination device, the valve unlock mechanism unlocks the valve locking mechanism, allowing opening of the valve and a fluid communication between the vessels.
[0180] In one or more embodiments, the second vessel further comprises a valve. In one or more embodiments, the valve of the second vessel is connected/engaged/coupled to a valve locking mechanism. In one or more embodiments, the second vessel includes a valve and a valve lock mechanism, and the first vessel includes a valve unlocking mechanism configured to unlock the valve locking mechanism of the second vessel.
[0181] Various forms of the valve locking mechanism are contemplated and applicable, including without limitation a hook, pin, retractable pin, locking key, latch, knob, lock, dent, hole, channel, bangle, slot, or a combination thereof. Various forms of the valve unlocking mechanism are contemplated and applicable, including without limitation a hook, pin, retractable pin, locking key, latch, knob, lock, dent, hole, channel, bangle, slot.
[0182] Various positions for the valve and/or valve lock mechanism and/or valve unlock mechanism are contemplated, such as within the vessel, within a tip or port of the vessel, on a surface of an aperture/tip/port of the vessel, on internal surfaces of side walls of the vessel. on a cavity of the vessel, extending through a wall of the vessel, and combinations thereof.
[0183] In one or more embodiments, the valve locking mechanism engages/couples with the valve unlocking mechanism at about the time of engagement/coupling of the first vessel and the second vessel.
[0184] Various motions can be applicable for opening the valve lock mechanism and/or the valve. In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a pushing motion of the second vessel towards the first vessel. In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a pushing motion of the first vessel towards the second vessel. In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a pushing motion of the first and second vessels towards each other.
[0185] In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a twisting motion of the first vessel in relation to the second vessel. In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a twisting motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a twisting motion of the first and second vessels in relation to each other.
[0186] In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a turning motion of the first vessel in relation to the second vessel. In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a turning motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a turning motion of the first and second vessels in relation to each other.
[0187] In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a push and twist motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a push and twist motion of the first vessel in relation the second vessel. In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a push and twist motion of the first and second vessels in relation to each other.
[0188] In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a twist and push motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a twist and push motion of the first vessel in relation the second vessel. In one or more embodiments, the unlocking of the valve locking mechanism is mediated via a twist and push motion of the first and second vessels in relation to each other.
[0189] Optionally, the valve locking mechanism is configured to be unlocked by a pushing motion of the first vessel towards the second vessel. Alternatively, the valve locking mechanism is configured to be unlocked by a pushing motion of the second vessel relative to the first vessel. Alternatively, the valve locking mechanism is configured to be unlocked by a pushing motion of the first and second vessels towards each other.
[0190] In one or more embodiments, at least one of a push and twist motions moves the valve locking mechanism from a locked position where the valve is unable to move to an unlocked position where the valve can move forward. In one or more embodiments, at least one of a push and twist motions moves the valve locking mechanism from a locked position where the valve is closed to an unlocked position where the valve is open and allows fluid to pass through the valve.
[0191] The present invention further provides a method for establishing a fluidic communication between vessels, the method comprising: [0192] providing a first vessel having a valve; [0193] providing a second vessel; and [0194] engaging/coupling the first and second vessels, wherein at about the time of engagement of the vessels, the valve opens, allowing the valve to open and establishment of a fluidic communication between the first and second vessels.
[0195] The present invention further provides a method for establishing a fluidic communication between vessels, the method comprising: [0196] providing a first vessel having a valve and a valve lock mechanism, the valve lock mechanism configured to lock the valve in a closed position; [0197] providing a second vessel; and [0198] engaging/coupling the first and second vessels, wherein at about the time of engagement of the vessels, the valve lock mechanism is unlocked, allowing the valve to open and establishment of a fluidic communication between the first and second vessels.
[0199] The present invention further provides a method for establishing a fluidic communication between vessels, the method comprising: [0200] providing a first vessel having a valve and a valve lock mechanism, the valve lock mechanism configured to lock the valve in a closed position; [0201] providing a second vessel having a valve unlock mechanism, the valve unlocking mechanism configured to unlock the valve of the first vessel; [0202] engaging/coupling the first and second vessels, wherein at about the time of engagement of the vessels, the valve locking mechanism is unlocked, allowing the valve to open and establishment of a fluidic communication between the first and second vessels.
[0203] In one or more embodiments, the herein disclosed devices and systems include a vessel with a plunger and a plunger lock mechanism that can lock the plunger, preventing premature transfer of the content from the vessel. Various forms of the plunger lock mechanism are herein contemplated. Non-limiting examples of the plunger locking mechanism include a latch, a spring, a magnet, a hook, a tooth, a pin, a retractable pin, a ratchet tooth, a knob, a retractable knob, a ball, a retractable ball, a thread, a bangle, a locking key, a zip-tie, a moveable wall. The plunger lock mechanism may be moveable between a locked position and an unlocked position. Optionally, the plunger lock position includes extension of the lock mechanism into a hole/dent/socket/channel. Optionally, in the plunger lock position, the lock mechanism is extended into the hole/dent/socket/channel and in the unlock position, the lock mechanism is retracted. In one or more embodiments, the vessel is a syringe. In one or more embodiments, the vessel is a cartridge. In one or more embodiments, the vessel is a container.
[0204] In one or more embodiments, the herein disclosed devices and systems include a vessel having a plunger, a plunger lock mechanism, a valve, and a valve lock mechanism. In one or more embodiments, the herein disclosed devices and systems further include the vessel having a piercing member and a piercing member lock mechanism. In one or more embodiments, the piercing member is a needle. In one or more embodiments, the vessel is a selected from a syringe, a cartridge, a vial, a container, a bottle, and combinations thereof.
[0205] In one or more embodiments, the herein disclosed devices and systems include a plunger unlock mechanism that can unlock the lock mechanism of the plunger. In one or more embodiments, the plunger unlock mechanism unlocks the lock mechanism at about the time of or following an engagement between a first vessel and a second vessel. Various forms of the unlock mechanism are herein contemplated. Non-limiting examples of the unlocking mechanism include a latch, a spring, a magnet, a hook, a tooth, a pin, a retractable pin, a ratchet tooth, a knob, a retractable knob, a ball, a retractable ball, a thread, a bangle, a locking key, a zip-tie, a moveable wall, a hole, a dent, a socket, a channel, an elongated arm, a latch, a lock, and a slot.
[0206] In one or more embodiments, the present invention provides a vessel having a moveable wall locking mechanism. In one or more embodiments, the present invention provides a vessel having a moveable wall and a moveable wall locking mechanism. In one or more embodiments, the present invention provides a vessel having a moveable wall unlocking mechanism. In one or more embodiments, the moveable wall is configured to expel the contents of the container out of the container. In one or more embodiments, the moveable wall is a plunger. In one or more embodiments, the vessel is a bottle, a vial, a syringe, a container, and combinations thereof.
[0207] In a further aspect, the present invention provides a method for establishing fluid communication between vessels, the method comprising: [0208] providing a first vessel having a plunger and a plunger locking mechanism; [0209] providing a second vessel having a plunger unlocking mechanism; [0210] connecting the first vessel to the second vessel; and [0211] pushing a plunger of the first vessels towards the second vessel to thereby establishing a fluid passageway between the vessels, wherein the plunger locking mechanism configured to lock the plunger thus preventing the plunger from moving and expelling a substance within the first vessel prior to the engagement between the first vessel and the second vessel, wherein the plunger unlocking mechanism configured to unlock the plunger locking mechanism of the first vessel; wherein upon the connection between the plunger unlocking mechanism and the plunger locking mechanism, the plunger locking mechanism is unlocked by the plunger unlocking mechanism thus allowing the plunger to move and expel the contents of the first vessel into the second vessel.
[0212] In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a pushing motion of the second vessel towards the first vessel. In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a pushing motion of the first vessel towards the second vessel.
[0213] In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a pushing motion of the first and second vessels towards each other.
[0214] In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a twisting motion of the first vessel in relation to the second vessel. In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a twisting motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a twisting motion of the first and second vessels in relation to each other.
[0215] In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a turning motion of the first vessel in relation to the second vessel. In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a turning motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a turning motion of the first and second vessels in relation to each other.
[0216] In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a push and twist motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a push and twist motion of the first vessel in relation the second vessel. In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a push and twist motion of the first and second vessels in relation to each other.
[0217] In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a twist and push motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a twist and push motion of the first vessel in relation the second vessel. In one or more embodiments, the unlocking of the plunger locking mechanism is mediated via a twist and push motion of the first and second vessels in relation to each other.
[0218] In one or more embodiments, at least one of a push and twist motions moves the plunger locking mechanism from a locked position where the plunger is unable to move to an unlocked position where the plunger is can move forward.
[0219] In one or more embodiments, the herein disclosed devices and systems include a vessel with a piercing member configured to pierce a seal/cover/membrane of a vessel. In one or more embodiments, the herein disclosed devices and systems include a vessel with a piercing member and a piercing member lock mechanism that can lock the piercing member, preventing premature seal/cover piercing. Various forms of the piercing member lock mechanism are herein contemplated. Non-limiting examples of the piercing member locking mechanism include a latch, a spring, a magnet, a hook, a tooth, a pin, a retractable pin, a ratchet tooth, a knob, a retractable knob, a ball, a retractable ball, a thread, a bangle, a locking key, a zip-tie, a moveable wall. The piercing member lock mechanism may be moveable between a locked position and an unlocked position. Optionally, the piercing member lock position includes extension of the lock mechanism into a hole/dent/socket/channel. Optionally, in the piercing member lock position, the lock mechanism is extended into the hole/dent/socket/channel and in the unlock position, the lock mechanism is retracted.
[0220] In one or more embodiments, the herein disclosed devices and systems include a piercing member unlock mechanism that can unlock the lock mechanism of the piercing member. In one or more embodiments, the piercing member unlock mechanism unlocks the lock mechanism at about the time of or following an engagement between a first vessel and a second vessel. Various forms of the unlock mechanism are herein contemplated. Non-limiting examples of the unlocking mechanism include a latch, a spring, a magnet, a hook, a tooth, a pin, a retractable pin, a ratchet tooth, a knob, a retractable knob, a ball, a retractable ball, a thread, a bangle, a locking key, a zip-tie, a moveable wall, a hole, a dent, a socket, a channel, an elongated arm, a latch, a lock, and a slot.
[0221] In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a pushing motion of the second vessel towards the first vessel. In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a pushing motion of the first vessel towards the second vessel. In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a pushing motion of the first and second vessels towards each other.
[0222] In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a twisting motion of the first vessel in relation to the second vessel. In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a twisting motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a twisting motion of the first and second vessels in relation to each other.
[0223] In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a turning motion of the first vessel in relation to the second vessel. In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a turning motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a turning motion of the first and second vessels in relation to each other.
[0224] In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a push and twist motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a push and twist motion of the first vessel in relation the second vessel. In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a push and twist motion of the first and second vessels in relation to each other.
[0225] In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a twist and push motion of the second vessel in relation to the first vessel. In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a twist and push motion of the first vessel in relation the second vessel. In one or more embodiments, the unlocking of the piercing member locking mechanism is mediated via a twist and push motion of the first and second vessels in relation to each other.
[0226] In one or more embodiments, at least one of a push and twist motions moves the piercing member locking mechanism from a locked position where the piercing member is unable to move to an unlocked position where the piercing member can move forward.
[0227] In a further aspect, the present invention provides a container having a plunger, a plunger lock mechanism, a valve, and a valve lock mechanism. In one or more embodiments, the container further comprising a piercing member and a piercing member lock mechanism. In one or more embodiments, the piercing member is a needle. In one or more embodiments, the container is selected from a vial, a bottle, a syringe, a cartridge, and combinations thereof.
[0228] In one embodiment, the present invention further provides devices, systems and methods configured to decontaminate one or more surfaces of a vessel(s). In one or more embodiments, the devices and systems of the invention allow a substantially decontaminated fluid transfer between the one or more vessel(s). The engagement and/or fluid transfer between the one or more vessels may accordingly be utilized via the decontamination devices which decontaminate the vessel(s) and also allow the fluid transfer. A locking mechanism and/or an unlocking mechanism may be disposed on the decontamination device, and one or both engaging vessels, thereby locking and unlocking a plunger.
[0229] In a further aspect, the present invention provides a system for decontaminating a surface of a vessel, the system comprising: [0230] a first vessel having a plunger lock mechanism, the plunger lock mechanism configured to lock a plunger within the vessel thus preventing premature movement thereof; [0231] a second vessel; and [0232] a decontamination device having a first and second ports for connection to the first and second vessels, the decontamination device comprising a wiper/wiping member disposed therein the device and configured to remove contaminants from a surface of at least one of the first and second vessels, the decontamination device further comprises a plunger unlock mechanism configured to unlock a plunger lock mechanism of the first vessel, [0233] wherein upon the engagement between the first vessel and the decontamination device, the lock mechanism is unlocked, allowing a fluid transfer between the first and second vessels via the decontamination device.
[0234] In one or more embodiments, the first vessel is a syringe. In one or more embodiments, the syringe has a plunger. In one or more embodiments, the first vessel is a cartridge. In one or more embodiments, the first vessel has a moveable wall. In one or more embodiments, the moveable wall is a plunger. In one or more embodiments, decontamination device has an actuator for effecting a wiping action of the wiping member. In one or more embodiments, the actuator is a handle. In one or more embodiments, the actuator is a tab.
[0235] In a further aspect, the present invention provides a method for establishing a fluid communication between vessels, the method comprises [0236] providing a first vessel having a plunger lock mechanism, the plunger lock mechanism configured to lock a plunger within the vessel thus preventing premature movement thereof; [0237] providing a second vessel; and [0238] providing a decontamination device having a first and second ports for connection to the first and second vessels, the decontamination device comprising a wiper/wiping member disposed therein the device and configured to remove contaminants from a surface of at least one of the first and second vessels, the decontamination device further comprises a plunger unlock mechanism configured to unlock a plunger lock mechanism of the first vessel, [0239] connecting the first vessel to the decontamination device; [0240] wherein upon the engagement between the first vessel and the decontamination device, the plunger unlock mechanism of the decontamination device unlocks the plunger lock mechanism of the first vessel, thus allowing for the movement of the plunger of the first vessel to expel the contents of the vessel into the decontamination device and thereby establish a fluid communication between the first vessel and the second vessel.
[0241] In one or more embodiments, the unlocking of the plunger lock mechanism of the first vessel occurs due to a pushing motion of the decontamination device towards the first vessel. In one or more embodiments, the unlocking of the plunger lock mechanism of the vessel occurs due to a pushing motion of the vessel towards the decontamination device. In one or more embodiments, the unlocking of the plunger lock mechanism of the vessel occurs due to a pushing motion of the vessel and the decontamination device towards each other.
[0242] In one or more embodiments, the unlocking of the plunger lock mechanism of the vessel occurs due to a twisting/turning motion of the decontamination device relative to the vessel. In one or more embodiments, the unlocking of the plunger lock mechanism of the vessel occurs due to a twisting/turning motion of the vessel relative to the decontamination device. In one or more embodiments, the unlocking of the plunger lock mechanism of the vessel occurs due to a twisting/turning motion of the vessel and the decontamination device relative to each other.
[0243] In one or more embodiments, the unlocking of the plunger lock mechanism of the vessel occurs due to a push and twist motion of the decontamination device relative to the vessel. In one or more embodiments, the unlocking of the plunger lock mechanism of the vessel occurs due to a push and twist motion of the vessel relative to the decontamination device. In one or more embodiments, the unlocking of the plunger lock mechanism of the vessel occurs due to a push and twist motion of the vessel and the decontamination device towards each other.
[0244] In one or more embodiments, the unlocking of the plunger lock mechanism of the vessel occurs due to a twist and push motion of the decontamination device relative to the vessel. In one or more embodiments, the unlocking of the plunger lock mechanism of the vessel occurs due to a twist and push motion of the vessel relative to the decontamination device. In one or more embodiments, the unlocking of the plunger lock mechanism of the vessel occurs due to a twist and push motion of the vessel and the decontamination device towards each other.
[0245] Optionally, the decontamination device includes an actuator, disposed through a wall of the device, for manipulating the movement of the wiping member, and thereby decontaminating the surface of the first and/or second vessels.
[0246] Optionally, the locking mechanism may be disposed on the vessel and/or the unlocking mechanism on the decontamination. Various positions of the locking/unlocking mechanism on the vessel and/or decontamination device are herein contemplated. The locking/unlocking mechanism may be disposed, without limitation, on a vessel's/device's body, port, aperture, wall, plunger and/or compartment. The locking mechanism may be disposed in an external and/or internal position of the vessel/device. Optionally, the decontamination device includes one or more compartments. Optionally, the decontamination device includes in a first compartment thereof a connecting structure/port for receiving a vessel. The connecting structure/port may mediate a connection with a vessel, via an engagement mechanism. Various forms of connecting structures/ports are herein contemplated. In one or more embodiments, the connecting structure/port extends downwardly from a top inner wall of a first compartment. In one or more embodiments, the connecting structure/port includes extension bodies (e.g., an elongated arm), clamping members, a threaded structure, minimized built-in dent structures, elongated extensions, and a circular body.
[0247] Various form of first and/or second vessels are contemplated. For example, the vessel may be a cartridge. In one or more embodiments, the cartridge includes protective side walls. In one or more embodiments, the moveable wall is a plunger. In one or more embodiments, the moveable wall is made of a rubber material. In one or more embodiments, the moveable wall is made of a plastic material. In one or more embodiments, the moveable wall is made of an elastomeric material. In one or more embodiments, at least one of the first and second vessels is a bag. In one or more embodiments, at least one of the first and second vessels is a bottle. In one or more embodiments, the first vessel is a bag and the second vessel is a syringe. In one or more embodiments, the first vessel is a syringe and the second vessel is a bag. In one or more embodiments, the first vessel is a bottle and the second vessel is a syringe. In one or more embodiments, the second vessel is a cartridge having a plunger.
[0248] Various types, combinations and numbers of plunger and/or valve and/or piercing member locking mechanisms may be provided in each of the herein disclosed systems and/or devices and/or container, to ensure the locking action. For example, a combination of two locking mechanisms or more may be provided in each device/system/vessel/container.
[0249] Various types, combinations and numbers of plunger and/or valve and/or piercing member unlocking mechanisms may be provided in each of the herein disclosed systems, to ensure the unlocking action. For example, a combination of two unlocking mechanisms or more may be provided in each device/system/vessel. In one or more embodiments, the locking mechanism is unlocked by the unlocking mechanism at the time of engagement of the first and second vessels. In one or more embodiments, the locking mechanism is unlocked by the unlocking mechanism after the engagement of the first and second vessels. In one or more embodiments, the locking and/or unlocking mechanism is disposed through a wall of the vessel. In one or more embodiments, the locking and/or unlocking mechanism is disposed on an interior wall of the vessel. In one or more embodiments, the locking and/or unlocking mechanism is disposed on an exterior wall of the vessel. In one or more embodiments, the locking and/or unlocking mechanism is disposed inside a wall of the vessel.
[0250] In one or more embodiments, the valve and/or plunger and/or piercing member unlock mechanism is operable to unlock a lock mechanism by displacing/removing a lock mechanism (e.g., a pin) from a channel/slot. In one or more embodiments, the valve and/or plunger and/or piercing member unlock mechanism is operable to unlock a lock mechanism by displacing/removing a lock mechanism (e.g., a stopper) from a dent. In one or more embodiments, the valve and/or plunger and/or piercing member unlock mechanism is operable to unlock a lock mechanism by displacing/removing a stopper from a protrusion of a valve/piercing member/plunger. In one or more embodiments, the valve and/or plunger and/or piercing member unlock mechanism is operable to unlock a lock mechanism by displacing/removing a latch from a valve and/or a plunger and/pre a piercing member.
[0251] In one or more embodiments, a portion of the valve and/or plunger and/or piercing member unlocking mechanism that engages/couples with the valve and/or plunger and/or piercing member locking mechanism is disposed in a wall of the vessel, inside the vessel, on an inner surface of the vessel or on an outer surface of the vessel, and combinations thereof.
[0252] In one or more embodiments, a portion of the valve and/or plunger and/or piercing member locking mechanism that engages/couples with the valve and/or plunger and/or piercing member unlocking mechanism is disposed in a wall of the vessel, inside the vessel, on an inner surface of the vessel or on an outer surface of the vessel.
[0253] In one or more embodiments, any of the valve locking mechanisms, piercing member locking mechanisms, and/or plunger locking mechanisms is selected from a stopper, a latch, a dent, a hole, a channel, a slot, a pin, a retention member, a fastener, and combinations thereof.
[0254] In one or more embodiments, any of the valve unlocking mechanisms, piercing member unlocking mechanisms, and/or plunger unlocking mechanisms is selected from a stopper, a latch, a dent, a hole, a channel, a slot, a pin, a retention member, a fastener, and combinations thereof.
[0255] Optionally, the valve, piercing member, and/or plunger includes a spring, optionally disposed in a wall of the vessel, for allowing an energy/force that will open/close the valve and/or piercing member and/or plunger.
[0256] Optionally, the valve locking mechanisms, piercing member locking mechanisms, and/or plunger locking mechanisms includes a spring, optionally disposed in a wall of the vessel, for allowing an energy/force that will open the valve and/or piercing member and/or plunger.
[0257] The decontamination device of the invention includes a housing having side walls, a top wall and a bottom wall, and a wiping member disposed within the housing. The device configured to be coupled to at least two vessels and includes applicable connecting structures/ports or openings for receiving the vessels. The connecting structures/ports/openings may optionally be formed by vertical walls extending from the top and/or bottom walls, forming an inner lumen via which medical substances may be transferred following engagement between, and decontamination of the vessel surfaces. Other port configurations include ports/openings without any walls. The ports may be flush, or surface mounted to the housing. Optionally, a locking and/or unlocking may be disposed in a port of the device, for example, in an internal position within vertical walls of the port. In one or more embodiments, the decontamination device may have a valve. In one or more embodiments, the decontamination device may have a valve and a valve lock mechanism. In one or more embodiments, the decontamination device has a valve and a valve locking mechanism. In one or more embodiments, the decontamination device has a valve unlocking mechanism.
[0258] The wiping member is configured to decontaminate a vessel's surface, optionally by a movement of the wiping member across the housing and surface of the vessel, or by movement of the surface of the vessel within the housing. The wiping member may be moveable or may be static. The wiping member may be made of a plastic material, an elastomeric material, a sponge-like material, and combinations thereof.
[0259] In an embodiment of the invention, the wiping member is operable to move across and wipe off any contaminates present on the one or more surfaces of the vessels via an actuator extending through an opening of the housing. The actuator is configured to manipulate movement of the wiping member across the housing. In one or more embodiments, the wiping member is operable to move across and wipe off any contaminants present on the one or more surfaces of the vessels via an actuator extending through an opening in the side wall of the housing. Exemplary actuators include, without limitation, a handle, a tab, a button, a touch button, a lever, a gear, a spring, a mechanical actuator, an electric actuator, an air pressure actuator, and combinations thereof.
[0260] In one or more embodiments, the wiping member is operable to move across and wipe off any contaminates present on the one or more surfaces of the vessels without any actuator for mediating the wiping action. In accordance with this embodiment, a user may, for example, apply force onto the housing to thereby forcibly manipulate the wiping member to slide across the housing. In accordance with this embodiment, the housing may be flexible, so the user can manipulate the wiping member from the outside and by applying for example press forces onto the housing. In one or more embodiments, the wiping member is moveable from an initial position which precedes the wiping action to an end position which follows the wiping action of the wiping member.
[0261] Optionally, the wiping member is static within the housing and the decontamination of a vessel's surface is effective via movement of the vessel, optionally a portion of the vessel, within the housing and via/through/under the wiping member. In accordance with this embodiment, the system optionally comprises a sliding mechanism positioned on at least one of the first vessel and the second vessel, and/or within and/or on the housing, the sliding mechanism configured to allow traveling there along of at least one of the first vessel and the second vessel, such that at least one of the first vessel and the second vessel is configured to move from a first position to a second position. IN one or more embodiments, the sliding mechanism is a rail mechanism. The wiping member is configured to remove contaminants from a surface of at least one of the first vessel and the second vessel at about the time, optionally at the time, of movement of the medical vessels from the first position to the second position. In one or more embodiments, the medical vessel or medical vessel surface slides along the housing and passes through and/or under and/or over the wiping member under great friction, or under a friction sufficient to wipe off any contaminants from the surface of the vessel, such as dirt, bacteria or ambient air particles.
[0262] Various types of sliding mechanisms are contemplated as long as they can be connected or engage a vessel and afford traveling there along and allow decontamination of a surface of the vessel. The sliding mechanism may include a rail. The rail may be optionally made from a plastic or polymetric material, but a metallic material or glass material is also applicable. In one embodiment, the rail is manufactured from a plastic material. In one or more embodiments, the plastic material is rigid. In one or more embodiments the vessel surface is positioned on a surface of the rail. In one or more embodiments, the vessel surface is positioned between the rails of the rail. In one or more embodiments, the vessel surface is positioned between a portion of the rails. In one or more embodiments, the rail may be a circumferential rail. In one or more embodiments, the sliding mechanism may include a hinge/pivot mechanism. In one or more embodiments, the sliding mechanism provides for the travelling a vessel between a plurality of positions, such as from a second position to a third position, from a third position to a fourth position, and from a fourth position to a fifth position. In one or more embodiments, the sliding mechanism allows only unidirectional sliding. Alternatively, the sliding mechanism allows for the vessel to retract/return to a previous position.
[0263] In one or more embodiments, the wiping member is manufactured from or comprises a material including, but not limited to an elastic material, a rigid material, a flexible material, an expandable material, a polymer, and combinations thereof. In one or more embodiments, the wiping member is manufactured from or comprises an elastomeric material, such as, but not limited to a rubber material. In one or more embodiments, the wiping member is manufactured from or comprises a sponge or a sponge-like material. In one or more embodiments, the wiping member slides across the surface of the one or more vessel(s) under great friction, or under a friction sufficient to wipe off any contaminants from the surface, such as dirt or bacteria. In one or more embodiments, the vessel's surface slides underneath the wiping member under great friction, or under a friction sufficient to wipe off any contaminants from the surface, such as dirt or bacteria.
[0264] In one or more embodiments, the wiping member is covered, at least partially, by a sterilizing substance. As used herein the term sterilizing substance encompasses any substance that can eliminate or reduce the presence of microorganisms, air particles, or any of the alike. In one embodiment, the term sterilizing substance is interchangeable with the term disinfecting substance. In one or more embodiments, the sterilizing substance may be, but is not limited to, an antibacterial substance, an antiviral substance (e.g., an anti-HIV agent), an anti-tuberculin substance, an anti-fungal, and combinations thereof.
[0265] In one or more embodiments, the sterilizing substance may be a bactericidal substance, a virucidal substance, and/or a fungicidal substance. Exemplary sterilizing substances include, without limitation, alcohol, isopropyl alcohol, and hydrogen peroxide. In one or more embodiments, the sterilizing or disinfecting substance may be a fluid or a liquid. In one or more embodiments, the sterilizing or disinfecting substance may be a gas. In one or more embodiments, the gas may be a pressurized gas. In one or more embodiments, the sterilizing substance may be housed within the housing of the decontamination device. In one or more embodiments, at least one of the openings and/or ports of the decontamination device are sealed and/or covered thus preventing the sterilizing substance from escaping from inside the housing of the decontamination device. The seals and/or covers maintain the sterility of the decontamination device until about the time of use of the decontamination device. In one or more embodiments, the sterilizing substance is sodium hypochlorite. In one or more embodiments, the concentration of sodium hypochlorite is 0.55% or higher. In one or more embodiments, the concentration of sodium hypochlorite is below 0.55% concentration.
[0266] In one or more embodiments, the housing may be manufactured from various materials. Optionally, the housing is manufactured from an inert material, thus suitable for various types of pharmaceutical substances. The housing may be made from flexible or from rigid materials. Suitable materials include, without limitation a plastic, a glass, a rigid plastic, a flexible plastic, and combinations thereof. In one or more embodiments, the housing may be transparent. In one or more embodiments, the housing may be opaque.
[0267] Various sizes and shapes of the housing are applicable. For example, the housing may have an external most length, width, and/or height of less than about 3 inches. In one or more embodiments, the housing may have an external most length, width, and/or height of less than about 25 millimeters (mm). For example, less than about 20 mm, less than about 15 mm, or less than about 10 mm. The housing internal most length, width, and/or height may be less than about 10 mm. For example, less than about 4 mm, less than about 3 mm, or less than about 2 mm. The housing may include one or more compartments which may optionally be separated or divided by the wiping member or by any other means. In one or more embodiments, the housing includes two compartments, wherein a first compartment is kept sterile and a second compartment is configured to receive a vessel which may be contaminated. In one or more embodiments, the sterile compartment can receive a vessel following decontamination of the surface of the vessel.
[0268] In one or more embodiments, the housing includes two compartments wherein a first includes a capping mechanism and the second is configured to receive a vessel. In one or more embodiments, the housing includes three, four, or five compartments. The vessel may move from a first position in which a vessel surface is located within the first compartment to a second position in which the vessel surface is located in the second compartment. Optionally, the housing includes a third compartment and the vessel surface is moveable from the second position to a third position. Optionally, the housing includes a fourth compartment, or a fifth compartment and the vessel surface is moveable from a third position to a fourth position and/or a fifth position.
[0269] In one or more embodiments, the housing is conveniently light presenting a weight of no more than about 100 grams (gr). For example, less than about 75 gr, less than about 50 mm gr, less than about 25 gr, less than about 10 gr, or less than about 5 gr. In one or more embodiments, the housing may be transparent allowing visualization of its interior, or opaque.
[0270] In one or more embodiments, the housing may be a closed chamber which forms a tight, optionally, airtight connection between the vessels. In one or more embodiments, when the ports or openings are connected to vessels or when the ports are covered by a cover or a seal, the housing may form an interior which is hermetically sealed/isolated from surrounding/environmental air. In one or more embodiments, the cover or the seal is frangible, breakable or rupturable. In one or more embodiments, the cover or the seal is pierceable by a piercing member such as a needle.
[0271] In one or more embodiments, the housing may optionally include one or more apertures, optionally covered by a filter, to thereby allow releasing air from the housing when actuating the wiping member. Optionally, the one or more apertures may be covered by a valve, to thereby allow releasing of air or pressure from within the housing when actuating the wiping member. In one or more embodiments, the valve may be a one-way valve, thereby allowing the release of air or pressure from within the housing when actuating the wiping member while preventing ambient or environmental air from entering the housing. In one or more embodiments, the filter or valve may be located in or on a wall of the housing's first, second or third compartment.
[0272] In one or more embodiments, the system or devices of the invention is provided when the housing is already connected to one or more medical vessels. In accordance with this embodiment, the one or more medical vessels may be integrally manufactured or assembled with the housing and provided or distributed to consumers as such. In accordance with this embodiment, the system may be configured to allow a connection/locking/engagement to additional one or more vessels.
[0273] In one or more embodiments, the system includes two or more housings each containing a wiping member. Optionally, the housings are disposed one above the other, providing a top housing and a bottom housing. In accordance with this embodiment, a wiping member disposed on the top housing is configured to wipe a surface of a vessel connected to the top housing and a wiping member disposed on the bottom housing is configured to wipe a surface of a vessel connected to the bottom housing.
[0274] In one or more embodiments, the system includes two or more ports which are disposed one above the other, or which are longitudinally aligned with respect to each other. In accordance with this embodiment, the vessels connected to such ports are positioned aligned allowing a direct and aligned fluid passageway between the vessels. In one or more embodiments, the system includes two or more ports which are shifted from each other. Yet, in accordance with this embodiment, a fluid passageway is formed between vessels which is twisted or curved. In yet one or more embodiments, the housing contains a plurality of ports configured for connecting a plurality of vessels to the housing. The system or device is configured so that actuating the wiping member allows wiping the surfaces of all vessels connected to the housing in one action.
[0275] In one or more embodiments, the housing has an engagement mechanism configured or adapted to connect the at least one vessel to the housing. In one or more embodiments, the engagement mechanism may be reversible, allowing to detach the engagement between a vessel and a decontamination device. Various types of engagement mechanisms may be applicable and are contemplated. For example, the engagement mechanism is selected from, without limitation, a thread, a luer, a luer-lock, a luer-slip, snap-on, twist-on, a ratchet teeth mechanism, a retention member, a clamping rail, and an adhesive mechanism. The thread and the complementary thread may be selected from, without limitation, a luer, a smart-site mechanism and combinations thereof. In an embodiment, the engagement mechanism may be selected from a ratchet teeth mechanism, a clamping rail mechanism and/or an adhesive. In one or more embodiments, the herein disclosed invention allows transferring medical substances in a contaminant-free, or in a substantially contaminant-free manner.
[0276] The term lock mechanism is interchangeable with the term locking mechanism.
[0277] The term unlock mechanism is interchangeable with the term unlocking mechanism.
[0278] In one or more embodiments, the herein disclosed invention affords an engagement of vessels in a contaminant-free, or in a substantially contaminant-free manner. In one or more embodiments, the herein disclosed invention affords an engagement of vessels in an air-free, or in a substantially air-free manner.
[0279] In one or more embodiments, the herein disclosed invention provides a fluidic passageway or communication between vessels in a contaminant-free, or in a substantially contaminant-free manner. In one or more embodiments, the herein disclosed invention provides a fluidic passageway or communication between vessels in an air-free, or in a substantially air-free manner.
[0280] In one or more embodiments, the herein disclosed invention, allows to substantially decrease the chances to introduce contaminants within a medical substance, when preparing or administering medical substances for administration to patients. In one or more embodiments, contaminants may be, but are not limited to, bacteria, viruses, fungus, ambient air particles, and pathogens.
[0281] As used herein the term substances refers to various types of materials that should be kept sterile. The substances may be liquid, semi-solid, or gas. In one or more embodiments, the substances are medical substances. As used herein the term medical substances refers to and encompasses any of the various pharmaceutical drugs, fluids, nutritional products and the like. In an embodiment of the invention the term medical substance is interchangeable with the terms a pharmaceutical substance, a beneficial substance and a medicament.
[0282] As used herein the term contaminant-free is interchangeable with the term sterile, disinfected, and decontaminated. The term refers to substances that are free or substantially free of ambient air particles and/or pathogens and/or micro-organisms, and/or any of the alike. Typically, when less or no air is introduced within medical substances, the chances of contamination by pathogens, such as, bacteria, viruses, funguses, spores, pyrogens or the alike is completely abolished or significantly reduced.
[0283] As used herein, the term substantially contaminant-free means significantly less ambient air present when transferring medical substances with the herein disclosed vessels and systems, as compared to comparable conditions for transferring medical substances without the herein disclosed vessels and systems.
[0284] As used herein the term ambient air particles is interchangeable with the term environmental air particles and refers to air particles present in a non-filtered environment. The air particles may contain dirt, such as dust. Alternatively, or additionally, the air particles may contain pathogens or other microorganisms, or any of the alike.
[0285] As used herein the term vessel refers to any device utilized for containing, transferring or administering substances as herein disclosed. In one or more embodiments, the vessels may be used for containing medical substances. In an embodiment of the invention, the vessel is a medical vessel. In one or more embodiments, the term medical vessel is interchangeable with the term pharmaceutical vessel. In an embodiment of the invention, the vessel is a medical device. In an embodiment of the invention, the vessels are used for, and adapted to allow connection to another vessel. In an embodiment of the invention, the vessel is utilized for containing or housing a medical substance. Various types of vessels are contemplated. The vessel may be selected, without limitation, from a vial, a syringe, a bag, a chamber, a bottle, a container, a cartridge and the alike. In an embodiment of the invention, the term vessel further encompasses elements that can be used to connect between vessels. In accordance with this embodiment, the vessel may be selected, without limitation, from a connector, a connector having a plurality of openings, a syringe, an infusion line, a tubing, an infusion line, a spike, a syringe, a filter, a port and a manifold. In one or more embodiments, the first container is a bag. In one or more embodiments, the herein system include a first vessel and a second vessel. In one or more embodiments, the first vessel is a cartridge configured to fill the second vessel. In accordance with this embodiment, the cartridge includes a mechanism for allowing the fluid transfer. Suitable fluid transfer mechanisms may include, without limitation a plunger, and a moveable wall. Optionally, the cartridge may have various forms, such as a syringe, a vial, a bottle, a bag, etc. In one or more embodiments, the first vessel is a bottle. In one or more embodiments, the first vessel is a syringe and the second vessel is a bag, or vice versa. In one or more embodiments, the first vessel is a syringe and the second vessel is a bottle, or vice versa. In one or more embodiments, the first vessel is a cartridge with a moveable wall and the second vessel is a bag. In one or more embodiments, the first vessel is a cartridge with a plunger and the second vessel is a bag. In one or more embodiments, the first vessel is a cartridge with a moveable wall and the second vessel is a bottle. In one or more embodiments, the first vessel is a cartridge with a plunger and the second vessel is a bottle. In one or more embodiments, at least one of the first and second containers is a bag. In one or more embodiments, at least one of the first and second vessels is a bottle. In one or more embodiments, the vessel is a cartridge having a plunger and protective side walls.
[0286] As used herein the term fluid communication refers to two or more vessels in which substances may pass therethrough either directly or indirectly. The fluid communication may occur via a fluid passageway that allows for the flow/transfer of substances. In an embodiment of the invention, fluid passageway between vessels is established when any seals or covers of the ports of the herein disclosed systems and/or of the vessels are open. Optionally, the vessels and/or ports of the systems are provided with seals/covers and those seals/cover become open upon piercing by a piercing member or breaking/rupturing thereof. Optionally, the vessels and/or ports of the systems are provided with seals/covers and those seals/covers are opened upon uncovering or removing thereof by a user. Optionally, one or more of the seals/covers disclosed herein are fragile, allowing piercing thereof with a sharp instrument (i.e., a piercing member) or by the application of a sufficient force to break or rupture the seals/covers. The piercing member may optionally be a needle, for example, a hollowed needle, but other sharp elements are contemplated. In one or more embodiments, the seals/covers may be peelable.
[0287] In an embodiment of the invention, the herein disclosed devices, systems and methods allow fluid communication in a contaminant-free, or in a substantially contaminant-free manner. For example, between three or more, four or more, five or more or six or more vessels. In an embodiment of the invention, the herein disclosed devices, systems and methods allow fluid communication between three, four, five six, or seven vessels. For example, the devices, systems, and methods of the invention allow fluid communication between two bags, between two containers, between two bottles, between a syringe and a bag, between a syringe and a container, between a syringe and a vial, between a connector and a bag, between a container and a bag, between a vial and a bag, between a container and an infusion line or between a syringe and a connector. Optionally, one vessel is configured to connect a plurality of vessels. For example, one vessel can connect two, or three, or four or five, or six or more vessels. Optionally, a second vessel can connect a plurality of first vessels. Optionally, the second vessel includes a plurality of cavities, each configured to accommodate and/or connect a vessel. In an embodiment of the invention, the herein disclosed devices and systems are disposable. In an embodiment of the invention, the herein disclosed devices and systems are non-disposable.
[0288] In one or more embodiments of the invention, the decontamination device has a valve, a valve locking mechanism, a valve unlocking mechanism, and combinations thereof. In one or more embodiments of the invention, the decontamination device has a valve, a valve lock mechanism, and a plunger unlock mechanism. In one or more embodiments of the invention, the decontamination device has a valve unlock mechanism and a plunger unlock mechanism. In one or more embodiments of the invention, the decontamination device has a valve unlock mechanism and a piercing member unlock mechanism. In one or more embodiments, the piercing member unlock mechanism is a needle unlock mechanism. In one or more embodiments of the invention, the decontamination device has a valve unlock mechanism, a plunger unlock mechanism, and a piercing member unlock mechanism.
[0289] Referring now to the drawings,
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[0321] Each of the following terms: includes, including, has, having, comprises, and comprising, and, their linguistic, as used herein, means including, but not limited to, and is to be taken as specifying the stated component(s), feature(s), characteristic(s), parameter(s), integer(s), or step(s), and does not preclude addition of one or more additional component(s), feature(s), characteristic(s), parameter(s), integer(s), step(s), or groups thereof. Each of these terms is considered equivalent in meaning to the phrase consisting essentially of.
[0322] Each of the phrases consisting of and consists of, as used herein, means including and limited to.
[0323] The term method, as used herein, refers to steps, procedures, manners, means, or/and techniques, for accomplishing a given task including, but not limited to, those steps, procedures, manners, means, or/and techniques, either known to, or readily developed from known steps, procedures, manners, means, or/and techniques, by practitioners in the relevant field(s) of the disclosed invention.
[0324] Throughout this disclosure, a numerical value of a parameter, feature, characteristic, object, or dimension, may be stated or described in terms of a numerical range format. Such a numerical range format, as used herein, illustrates implementation of some exemplary embodiments of the invention, and does not inflexibly limit the scope of the exemplary embodiments of the invention. Accordingly, a stated or described numerical range also refers to, and encompasses, all possible sub-ranges and individual numerical values (where a numerical value may be expressed as a whole, integral, or fractional number) within that stated or described numerical range. For example, a stated or described numerical range from 1 to 6 also refers to, and encompasses, all possible sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., and individual numerical values, such as 1, 1.3, 2, 2.8, 3, 3.5, 4, 4.6, 5, 5.2, and 6, within the stated or described numerical range of from 1 to 6. This applies regardless of the numerical breadth, extent, or size, of the stated or described numerical range.
[0325] Moreover, for stating or describing a numerical range, the phrase in a range of between about a first numerical value and about a second numerical value, is considered equivalent to, and meaning the same as, the phrase in a range of from about a first numerical value to about a second numerical value, and, thus, the two equivalently meaning phrases may be used interchangeably.
[0326] The term about, is some embodiments, refers to 30% of the stated numerical value. In further embodiments, the term refers to 20% of the stated numerical value. In yet further embodiments, the term refers to 10% of the stated numerical value.
[0327] It is to be fully understood that certain aspects, characteristics, and features, of the invention, which are, for clarity, illustratively described and presented in the context or format of a plurality of separate embodiments, may also be illustratively described and presented in any suitable combination or sub-combination in the context or format of a single embodiment. Conversely, various aspects, characteristics, and features, of the invention which are illustratively described and presented in combination or sub combination in the context or format of a single embodiment, may also be illustratively described and presented in the context or format of a plurality of separate embodiments.
[0328] Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications, and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications, and variations that fall within the spirit and broad scope of the appended claims.
[0329] All publications, patents, and patent applications mentioned in this specification are herein incorporated in their entirety by reference into the specification, to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated herein by reference. In addition, citation or identification of any reference in this application shall not be construed as an admission that such reference is available as prior art to the present invention. To the extent that section headings are used, they should not be construed as necessarily limiting.