TABLETS WITH HIGH ACTIVE INGREDIENT CONTENT OF OMEGA-3 FATTY ACID AMINO ACID SALTS

Abstract

The present invention relates to a tablet comprising one or more omega-3 fatty acid amino acid salt(s), a method for preparing a tablet according to the invention and the use of a tablet according to the invention as a food supplement or as a pharmaceutical product.

Claims

1-12. (canceled)

13. A tablet, comprising an omega-3 fatty acid amino acid salt comprising an omega-3 fatty acid and an amino acid, a total amount of 20 wt % or less, based on a total weight of the tablet, of a binder and/or a structure-forming substance selected from the group consisting of polyvinylpyrrolidone (PVP), starch, lactose, microcrystalline cellulose, calcium sulphate, mannitol, calcium phosphate and mixtures thereof, and a total amount of 40 wt % or more, based on the total weight of the tablet, of the omega-3 fatty acid.

14. The tablet of claim 13, comprising a total amount of 10 wt % or less, based on the total weight of the tablet, of the binder and/or the structure-forming substance.

15. The tablet of claim 13, wherein the omega-3 fatty acid is selected from the group consisting of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and mixtures thereof.

16. The tablet of claim 13, wherein the amino acid is basic.

17. The tablet of claim 13, wherein the amino acid is selected from the group consisting of lysine, arginine, ornithine and mixtures thereof.

18. The tablet of claim 13, comprising a total amount of 50 wt % or more, based on the total weight of the tablet, of the omega-3 fatty acid.

19. A method of preparing the tablet of claim 13, the method comprising: compressing the omega-3 fatty acid amino acid salt, optionally together with the binder and/or the structure-forming substance.

20. The method of claim 19, comprising: compacting the omega-3 fatty acid amino acid salt prior to the compressing.

21. The method of claim 19, comprising: granulating the omega-3 fatty acid amino acid salt with a solvent or a solvent mixture prior to the compressing.

22. The method of claim 19, comprising: precipitating the omega-3 fatty acid amino acid salt from an aqueous or alcoholic aqueous solution.

23. The method of claim 19, comprising: spray-drying of an aqueous or alcoholic aqueous solution to obtain the omega-3 fatty acid amino acid salt.

24. A food supplement or a pharmaceutical product, comprising the tablet of claim 13.

25. The method of claim 20, comprising: granulating the omega-3 fatty acid amino acid salt with a solvent or a solvent mixture prior to the compacting.

Description

EXAMPLE 1

[0029]

TABLE-US-00001 Amount Amount Material [% by weight] [g] Omega-3 fatty acid lysine salt 85.00 255.00 Mg stearate 1.00 3.00 Cornstarch (cold swelling) 6.50 19.50 PVP 6.50 19.50 Aerosil 200 Pharma 1.00 3.00 (highly dispersed silicon dioxide) Sum total 100.00 300.00

[0030] The formula could be compressed with 219 mm oblong punches at 5 kN compression force to 50 N hard tablets. The omega-3 fatty acid lysine salt used had a content of omega-3 fatty acids (sum of EPA+DHA) of 48% by weight. This resulted in a content of omega-3 fatty acids of the finished tablets of 41% by weight.

EXAMPLE 2

[0031]

TABLE-US-00002 Amount Material [% by weight] Omega-3 fatty acid lysine salt (EPA-lysinate) 86.40 Na starch glycolate 2.90 Hydroxy-propyl-methyl-cellulose (HPMC E5) 2.10 Talkum 4.00 Aerosil 200 Pharma (highly dispersed silicon dioxide) 3.00 Mg-stearate 1.60 Sum total 100.00

[0032] This formula could also directly be compressed to tablets. The omega-3 fatty acid lysine salt used had a content of omega-3 fatty acids (EPA) of 65% by weight. This resulted in a content of omega-3 fatty acids of the finished tablets of 56.1%.