Abstract
The dosing apparatus comprises a conveying device (5), which is driven by at least one conveying drive (4), for conveying fluid from the interior (3) of a container (2). The fluid by means of the conveying device (5) is conveyable from the container to a dispensing opening (6). The conveying device (5) comprises a cylinder (7) having at least one intake opening (11) and at least one outlet opening (12) on an inner cylinder wall (8), and a first piston (9) and a second piston (10). The first piston (9) and the second piston (10) are mounted within the cylinder (7) so as to be displaceable in the longitudinal direction. Furthermore, the first piston (9) and the second piston (10) between the end sides thereof and together with a portion of the inner cylinder wall (8) delimit a variable fluid volume (17).
Claims
1-20. (canceled)
21. A dosing device for dispensing a fluid under aseptic conditions, comprising at least one container with an interior, and a conveying device which is driven by at least one conveying drive in order to convey the fluid out of the interior of the at least one container, wherein the fluid is conveyable by means of the conveying device from the container to a dispensing opening, wherein the conveying device comprises a cylinder, with at least one intake opening and at least one outlet opening on a cylinder inner wall, and also a first piston and a second piston, wherein the first piston and the second piston are mounted inside the cylinder in such a way as to be displace able in the longitudinal direction, and wherein the first piston and the second piston, between the end faces thereof and together with a portion of the cylinder inner wall, delimit a variable fluid volume, characterized in that the dosing device comprises a drive module and a dispensing module which are configured so as to be mutually connectable and separable by a user, wherein the drive module comprises at least parts of the conveying drive, in particular optionally a rotary drive, and/or optionally an application drive of an injection device, and the dispensing module has at least the container and also the conveying device and optionally the injection device, and the container is at least partially collapsible.
22. The dosing device according to claim 20, wherein the intake opening and the outlet opening are disposed on the cylinder in a manner offset in the longitudinal direction.
23. The dosing device according to either of claim 20, wherein the intake opening is fluidically connectable to the interior of a container, and the outlet opening is fluidically connect able to the dispensing opening.
24. The dosing device according to one of claim 20, wherein the conveying device has a pressure sensor which is preferably disposed on the cylinder, in particular in the longitudinal direction at the level of the outlet opening.
25. The dosing device according to one of claim 20, wherein the conveying device additionally comprises a filling opening which is fluidically connectable to the intake opening by displacement of the first piston and of the second piston inside the cylinder.
26. The dosing device according to claim 25, wherein the filling opening and the intake opening are disposed on the cylinder in a manner offset in the longitudinal direction.
27. The dosing device according to either of claim 25, wherein the filling opening is fluidically connectable to a coupling means, in particular a Luer coupling, for the coupling of a fluid source, wherein advantageously a valve device, preferably a duckbill valve, which blocks the filling opening towards the outside in relation to a fluid stream from the conveying device, is disposed in fluid communication between the filling opening and the coupling means.
28. The dosing device according to one of claim 20, wherein the conveying device comprises at least two intake openings, which are disposed on the cylinder in a manner offset in the longitudinal direction.
29. The dosing device according to claim 28, wherein each intake opening is fluidically connectable to the interior of a separate and at least partially collapsible container assigned to it.
30. The dosing device according to claim 28, wherein at least two intake openings are each fluidically connectable to a separately demarcated interior of a container, wherein the separately demarcated interiors are configured in such a way that at least two fluids are receivable separately from each other in the container.
31. The dosing device according to one of claim 20, wherein the at least one container additionally comprises a closure piece, wherein the closure piece is in particular disposed fixedly in the container and is fluidically connectable to the conveying device via an attachment channel.
32. The dosing device according to one of claim 20, wherein the conveying device additionally comprises an analysis opening which is disposed on the cylinder, in a manner offset in the longitudinal direction in relation to the intake opening or the intake openings and to the outlet opening, and which is fluidically connectable to an analysis device.
33. The dosing device according to one of claim 20, the first piston is derivable by a first conveying drive, and the second piston is drivable by a second conveying drive.
34. The dosing device according to one of claim 20, wherein the first piston and the second piston are drivable by a common conveying drive.
35. The dosing device according to claim 34, wherein at least one piston is operatively connectable to the conveying drive in an indirect manner.
36. The dosing device according to claim 35, wherein a piston that is operatively connect able to the conveying drive in an indirect manner is operatively connectable to the conveying drive via a spring element, which is preferably disposed in the interior of said piston.
37. The dosing device according to one of claim 20, wherein the first piston and the second piston are formed integrally and are connected to each other via a bellows.
38. The dosing device according to one of claim 20, at least one conveying drive is configured as a spindle drive.
39. The dosing device according to one of claim 20, wherein at least one conveying drive comprises a cam gear.
40. The dosing device according to one of claim 20, wherein the dosing device comprises an injection device for preferably continuous subcutaneous dispensing of a fluid to a patient.
Description
[0045] Further advantages and individual features of the invention may be derived from the following description of a plurality of exemplary embodiments and from the drawings in which, in a schematic manner:
[0046] FIG. 1: Shows a perspective illustration of a dosing apparatus according to the invention;
[0047] FIGS. 2a-2f: Show a series of longitudinal sections through a conveying device of a dosing apparatus according to the invention, for visualizing a pumping procedure;
[0048] FIG. 3: Shows a longitudinal section through a conveying device of a dosing apparatus according to the invention, having a pressure sensor;
[0049] FIGS. 4a-4d: Show a series of longitudinal sections through a conveying device of a dosing apparatus according to the invention, for visualizing a filling procedure;
[0050] FIGS. 5a-5d: Show a longitudinal section through a conveying device of an alternative exemplary embodiment of a dosing apparatus according to the invention, for visualizing a filling procedure;
[0051] FIG. 6: Shows a longitudinal section through a conveying device of a dosing apparatus according to the invention, having two independent conveying drives;
[0052] FIG. 7: Shows a longitudinal section through a conveying device of an alternative exemplary embodiment of a dosing apparatus according to the invention, having two independent conveying drives;
[0053] FIG. 8: Shows a longitudinal section through a conveying device of a dosing apparatus according to the invention, having three intake openings;
[0054] FIGS. 8a-8i: Show a series of part-enlargements through longitudinal sections of a conveying device according to FIG. 8, for visualizing a pumping procedure;
[0055] FIG. 9: Shows a longitudinal section through a conveying device of a dosing apparatus according to the invention, having an additional analysis opening;
[0056] FIGS. 9a-9j: Show a series of part-enlargements of longitudinal sections through a conveying device according to FIG. 9, for visualizing an analysis and pumping procedure;
[0057] FIGS. 10a-10e: Show a series of longitudinal sections through a conveying device of a dosing apparatus according to the invention, having a common drive for both pistons;
[0058] FIGS. 11a-11e: Show a series of longitudinal sections through a conveying device of an alternative exemplary embodiment of a dosing apparatus according to the invention, having a common drive for both pistons;
[0059] FIG. 12a: Shows a spatial illustration of a longitudinal section according to FIG. 11c;
[0060] FIG. 12b: Shows the bellows 34 marked by a circle in FIG. 12a, but in a non-sectional form;
[0061] FIGS. 13a-13d: Show a series of longitudinal sections through a conveying device of an alternative exemplary embodiment of a dosing apparatus according to the invention, having two independent piston drives which are configured as cam gears;
[0062] FIGS. 14a-14e: Show a series of longitudinal sections through a conveying device of an alternative exemplary embodiment of a dosing apparatus according to the invention, for installation in a filling station for liquid pharmaceuticals.
[0063] FIG. 1 shows a perspective illustration of a dosing apparatus 1 according to the invention. Said dosing apparatus additionally comprises a collapsible container 2, the fluid to be dispensed being contained in the interior 3 thereof. The container 2 is connected to the conveying device 5 via a connection duct 24 in the closure piece 23. The conveying device 5 comprises a cylinder 7 in which a first piston 9 and a second piston 10 are displaceably mounted. An intake opening 11 for suctioning the fluid from the container 2 is attached to the cylinder 7. In order for the fluid to be dispensed from the dosing apparatus 1, an outlet opening 12 which is fluidically connected with the dispensing opening 6 is moreover attached to the cylinder 7. In the exemplary embodiment shown, additionally a pressure sensor 13 as well as a filling opening 14 which is closed off by a stopper 22 are attached to the cylinder 7. The first piston 9 and the second piston 10 in the exemplary embodiment shown are driven by a common conveying drive 4 which here is configured as a spindle drive.
[0064] The operating principle of the conveying device 5 of a dosing apparatus 1 according to FIG. 1 is illustrated in FIGS. 2a-f. FIG. 2a shows a longitudinal section through the conveying device 5 in the initial state thereof. The two pistons 9 and 10 are mounted so as to be displaceable in the cylinder 7. In order for a fluid-tight contact between the pistons 9 and 10 and the inner cylinder wall 8 to be established, a plurality of annular seals 21 are attached to the pistons 9 and 10. Moreover, an intake opening 11 and an outlet opening 12 are present on the cylinder 7 of the conveying device 5. In the initial position of the conveying device 5, the two pistons 9 and 10, having end-side contact, are positioned so as to be level with the intake opening 11. FIG. 2b shows the conveying device 5 after suctioning of fluid has been performed. It can be seen that the first piston 9 has been displaced in the direction of the outlet opening 12, on account of which a volume 17 which is delimited internally and by the inner cylinder wall 8 has been formed between the end sides of the two pistons 9 and 10. In FIG. 2c the two pistons 9 and 10 are displaced in the direction of the outlet opening 12, so as to be mutually equidistant. In FIG. 2d, the first piston 9 in the longitudinal direction of the cylinder 7 is now level with the outlet opening 12. In order for the liquid to be ejected, the second piston 10, proceeding from this position, may displaced further in the direction of the first piston 9 up to the point at which the two pistons 9 and 10 have end-side contact, as is shown in FIG. 2f. However, the two pistons 9 and 10, proceeding from a position according to FIG. 2d, may also be further displaced in an equidistant manner up to the point where the second piston 10 is level with the outlet opening 12, corresponding to FIG. 2e. Proceeding from here, an alternative ejection principle, in which the first piston 9 is displaced in the direction of the second piston 10, is implementable.
[0065] FIG. 3 shows an alternative exemplary embodiment of a conveying device 5 of a dosing apparatus 1 according to the invention, in which additionally a pressure sensor 13 is attached to the cylinder 7, so as to be level with the outlet opening 12.
[0066] A sequence of longitudinal sections through the conveying device 5 of a further exemplary embodiment of a dosing apparatus 1 according to the invention is shown in FIGS. 4a-d. An additional filling opening 14 is attached to the cylinder 7 in the case of said conveying device. FIG. 4a shows the conveying device 5 in the initial position thereof, prior to filling the container 2. The two pistons 9 and 10, having end-side contact, in the longitudinal direction of the cylinder 7 are positioned so as to be level with the intake opening 11 and the filling opening 14. As can be seen in FIG. 4b, fluid communication between the filling opening 14 and the intake opening 11 is established by displacing the first piston 9 in the direction of the outlet opening 12. The interior 3 of the container 2 may be filled with fluid on account of this fluid communication. After the filling procedure has been performed, the filling opening 14 is closed according to FIG. 4c, using a stopper 22. In FIG. 4d, the conveying device 5 having a filled container 2 is again shown in the initial position of the former.
[0067] FIGS. 5a-d highlight the filling procedure of an alternative exemplary embodiment of a dosing apparatus 1 according to the invention. A longitudinal section through a corresponding conveying device 5 in which the filling opening 14 and the intake opening 11 are disposed on the cylinder 7 so as to be offset in the longitudinal direction is shown in FIG. 5a. In order for the dosing apparatus 1 to be filled, the first piston 9 is displaced in the direction of the outlet opening 12 (FIG. 5b), so as to establish fluid communication between the filling opening 14 and the intake opening 11. As is illustrated in FIG. 5c, said fluid communication may again be interrupted after filling of the container 2 has been performed, by again displacing the piston 9 in the direction of the second piston 10. The filling opening 14 is closed off using a stopper 22 as the last step of the filling procedure (FIG. 5d).
[0068] FIG. 6 shows a part-section through a dosing apparatus 1 according to the invention, in which the conveying device 5 is driven by two independent conveying drives 4 and 4. The two conveying drives 4 and 4 here are of identical construction and comprise in each case one motor 25 having a transmission 26. The rotation movement generated by the motor 25 is transmitted to a spindle housing 28 which is rotatably mounted by way of the bearings 29. The spindle housing 28 has a bore having a thread 30 into which the spindle 27 engages. On account thereof, a rotation movement which has been generated by the motor and the transmission 26 may be converted into a longitudinal movement of the piston 9 or 10. In said exemplary embodiment, a filling opening 14 is attached to the conveying device 5, so as in the longitudinal direction to be level with the intake opening 11, and is closed off by way of a stopper 22.
[0069] FIG. 7 shows an alternative exemplary embodiment of a dosing apparatus 1 according to the invention, having the conveying drive 4 and 4 according to FIG. 6. However, the filling opening 14 here is disposed on the cylinder 7 of the conveying device 5, so as to be offset in the longitudinal direction in relation to the intake opening 11.
[0070] FIG. 8 shows a further exemplary embodiment of a dosing apparatus 1 according to the invention, having a conveying device 5 which has three independent intake openings 11, 11, and 11. FIGS. 8a-i represent a series of longitudinal sections of said conveying device 5, corresponding to a part-enlargement of FIG. 8. In FIG. 8a the conveying device 5 is shown in the initial position thereof, wherein the first piston 9 and the second piston 10 are in end-side contact, so as to be level with the first intake opening 11. In FIG. 8b the first piston 9 is displaced in the direction of the outlet opening 12, on account of which a volume 17 for suctioning fluid is formed between the end sides of the first piston 9 and of the second piston 10 and the inner cylinder wall 8. In FIG. 8c the two pistons 9 and 10 in the longitudinal cylinder direction are displaced in an equidistant manner, so as to be level with the second intake opening 11. By again moving the first piston 9 in the direction of the outlet opening 12, further fluid may be suctioned through the intake opening 11 (FIG. 8d). In FIG. 8e, the two pistons 9 and 10 are again offset in an equidistant manner in the direction of the dispensing opening 12, so as to be level with the third intake opening 11. Here too, fluid may be suctioned through the intake opening 11 by displacing the first piston 9 in the direction of the outlet opening 12 (FIG. 8f). FIG. 8g shows equidistant displacement of the first piston 9 and of the second piston 10 in relation to the dispensing opening 12. FIG. 8h illustrates the conveying device 5 in the ready state for dispensing, with the second piston 10 being level with the outlet opening 12. After the fluid has been dispensed by displacing the first piston 9 in the direction of the second piston 10, there is again end-side contact between the two pistons 9 and 10, as is shown in FIG. 8i.
[0071] FIG. 9 shows a longitudinal section through a further exemplary embodiment of a dosing apparatus 1 according to the invention, having an additional analysis opening 15 on the cylinder 7 of the conveying device 5. The corresponding conveying device 5 is shown in part-enlargement in FIG. 9a. The two pistons 9 and 10 are located in the initial position, the end sides thereof in the longitudinal direction of the cylinder 7 being level with the intake opening 11. In a first step, the two pistons 9 and 10 are displaced so as to be level with the outlet opening 12, as is highlighted in FIG. 9b. Thereafter, fluid, for example a patient's blood, is received in the dosing apparatus 1 through the outlet opening 12 by moving the first piston 9 in the direction of the analysis opening 15 (FIG. 9c). The received fluid by equidistant displacement of the pistons 9 and 10 is thereafter moved to the analysis opening 15 (FIG. 9d). The fluid is dispensed through the analysis opening 15 to an analysis device by moving the second piston 10 in the direction of the first piston 9. Once dispensing has been performed, the conveying device 5 having end-side contact between the first piston 9 and the second piston 10 according to FIG. 9e is established. Accordingly, the pistons are thereafter collectively offset to the initial position according to 9f. As is shown in FIGS. 9g-j, thereafter a dosage of fluid which has been determined by the analysis device may be taken into the conveying device 5 and dispensed to a patient.
[0072] FIGS. 10a-e show an exemplary embodiment of a dosing apparatus 1 according to the invention, in which the two pistons 9 and 10 of the conveying device 5 are driven by a common conveying drive 4. The first piston 9 here is indirectly coupled via a compression spring 33 to the conveying drive 4, while the second piston 10 is connected in a floating manner to the conveying drive 4. As can be seen in FIG. 10b, actuation of the conveying drive, proceeding from the initial position in FIG. 10a, first leads to sole displacement of the first piston 9 in the direction of the outlet opening 12. Once the desired fluid volume 17 between the two pistons 9 and 10 has been reached, the second piston 10 is displaced in an equidistant manner to the first piston 9 in the direction of the dispensing opening 12, as is shown in FIG. 10c. In FIG. 10d the first piston 9 in the longitudinal direction of the cylinder 7 has now reached a position which is level with the dispensing opening 12. It can be seen that the piston rod 16 of the first piston at this point also contacts the stop 32. Further actuation of the conveying drive 4 leads to the spring 33 being compressed, as is shown in FIG. 10e, on account of which the second piston 10 is further displaced in the direction of the dispensing opening 12, again leading to dispensation of the fluid volume having been taken in.
[0073] FIGS. 11a-e show a further exemplary embodiment of a dosing apparatus 1 according to the invention, in which the conveying device 5 is driven by only one conveying drive 4. The first piston 9 here is operatively connected in an indirect manner via the spring element 40 which is disposed therein with the conveying drive 4. The second piston 10 by way of the piston rod 16 may be pushed in the direction of the outlet opening 12, and by way of the first piston 9 in the direction of the intake opening 11. The first piston 9 and the second piston 10 are configured so as to be integral and are interconnected by way of a bellows 34. In this way, the pistons 9 and 10 and the bellows 34 may be implemented from a single part, for example from silicone, TPE, or bromobutyl rubber, for example.
[0074] FIG. 12a shows a spatial illustration of a longitudinal section according to FIG. 11c. It can be seen that the first piston 9 and the second piston 10 are displaced in an equidistant manner in the direction of the outlet opening 12. Here, the first piston 9 is moved by way of the spring element 40, and the second piston 10 is pushed by the piston rod 16. FIG. 12b shows the bellows 34 which is marked by a circle in FIG. 12a, but not as part-section but in a spatial illustration.
[0075] FIGS. 13a-d show a further dosing apparatus 1 according to the invention, in which the pistons 9 and 10 of the conveying device 5 are driven by two independent conveying drives 4 and 4. However, in this case, these are two cam gears 18 and 18. Said cam gears 18 and 18 comprise in each case one control disc 19 having a guide groove 31 by way of which a plunger 20 is articulated thereon.
[0076] FIGS. 14a-e show the conveying device 5 of a further alternative exemplary embodiment of a dosing apparatus 1 according to the invention, for installation in a filling station for liquid pharmaceutical formulae. The conveying device 5 in this case has a cylinder 7 which is integrally embodied as a U-shaped housing 36. While the first piston 9 transitions into a typical straight piston rod 16, the second piston 10 is connected to a U-shaped piston rod 35 which has a bend of 180. The conveying device 5 is not only without a valve, but is also conceived so as to have no seals or piston rings on the pistons. The housing 36 has a space 37 for the bend in the piston rod 35, and ducts 38 and 39 for flushing the conveying device 5.
