PESTICIDAL COMPOSITION COMPRISING AN OXIME CARBAMATE AND USE THEREOF

Abstract

A soluble liquid concentrate (SL) composition is provided. The composition comprising: i) an oxime carbamate; ii) a carboxylic acid stabiliser; and iii) a liquid carrier.

Claims

1. A soluble liquid concentrate (SL) composition comprising: i) an oxime carbamate; ii) a carboxylic acid stabiliser; and iii) a liquid carrier.

2. The composition according to claim 1, where the composition comprises a single oxime carbamate.

3. The composition according to claim 1, wherein the oxime carbamate is selected from alanycarb, aldicarb, aldoxycarb, butocarboxim, butoxycarboxim, methomyl, nitrilcarb, oxamyl, tazimcarb, thiocarboxime, thiodicarb, thiofanox and mixtures thereof.

4. The composition according to claim 3, wherein the oxime carbamate is selected from oxamyl, methomyl and mixtures thereof

5. The composition according to claim 4, wherein the oxime carbamate comprises oxamyl.

6. The composition according to claim 1, wherein the oxime carbamate is present in an amount of up to 60% by weight.

7. The composition according to claim 6, wherein the oxime carbamate is present in an amount of up to 45% by weight.

8. The composition according to claim 1, wherein the oxime carbamate is present in an amount of at least 5% by weight.

9. The composition according to claim 8, wherein the oxime carbamate is present in an amount of at least 20% by weight.

10. The composition according to claim 1, wherein the carboxylic acid is an aliphatic carboxylic acid.

11. The composition according to claim 1, wherein the carboxylic acid has from 1 to 8 carbon atoms.

12. The composition according to claim 11, wherein the carboxylic acid is selected from formic acid, acetic acid, propionoic acid, butyric acid, valeric acid, caproic acid and benzoic acid.

13. The composition according to claim 12, wherein the carboxylic acid is acetic acid.

14. The composition according to any preceding claim claim 1, wherein the composition has a pH of up to 6.5.

15. The composition according to claim 14, wherein the composition has a pH of up to 4.0.

16. The composition according to claim 15, wherein the composition has a pH of from 3.0 to 4.0.

17. The composition according to claim 1, wherein the carboxylic acid is present in an amount of from 0.5 to 5% by weight.

18. The composition according to claim 1, wherein the liquid carrier is present in an amount of up to 80% by weight of the composition.

19. The composition according to claim 1, wherein the liquid carrier is present in an amount of from 40% by weight of the composition.

20. The composition according to claim 1, wherein the liquid carrier is present in an amount of from 65 to 85% by weight of the composition.

21. The composition according to claim 1, wherein the liquid carrier comprises an alcohol.

22. The composition according to claim 21, wherein the alcohol is a monohydric alcohol.

23. The composition according to claim 21, wherein the alcohol has from 1 to 8 carbon atoms.

24. The composition according to claim 23, wherein the alcohol is selected from methanol, ethanol, propanol, butanol, pentanol and hexanol.

25. The composition according to claim 21, wherein the liquid carrier comprises methanol or ethanol.

26. The composition according to claim 20, wherein the alcohol is present in the composition in an amount of up to 50% by weight.

27. The composition according to claim 26, wherein the alcohol is present in the composition in an amount of from 5% by weight.

28. The composition according to claim 1, wherein the liquid carrier comprises a carbonate ester.

29. The composition according to claim 28, wherein the carbonate ester has the general formula: ##STR00003## in which R1 is selected from hydrogen or a lower alkyl group.

30. The composition according to claim 29, wherein R1 is methyl.

31. The composition according to claim 28, wherein the carbonate ester is present in the composition in an amount of up to 50% by weight.

32. The composition according to claim 28, wherein the carbonate ester is present in the composition in an amount of from 5% by weight.

33. The composition according to claim 1, wherein the liquid carrier comprises water.

34. (Originally Filed) The composition according to claim 33, wherein water is present in the composition in an amount of up to 60% by weight.

35. The composition according to claim 33, wherein water is present in the composition in an amount of from 5% by weight.

36. The composition according to claim 1, wherein the liquid carrier comprises an alcohol and a carbonate ester in a weight ratio of from 1:10 to 10:1.

37. The composition according to claim 1, wherein the liquid carrier comprises an alcohol and water in a weight ratio of from 1:8 to 8:1.

38. The composition according to claim 1, wherein the liquid carrier comprises a carbonate ester and water in a weight ratio of from 1:12 to 12:1.

39. The composition according to claim 1, further comprising one or more auxiliaries selected from surfactants, stabilizers, anti-foaming agents, anti-freezing agents, preservatives, antioxidants, and colorants.

40. A method for the treatment of pest infestations at a locus, the method comprising applying to the locus a composition according to claim 1.

41. The use of a composition according to claim 1 in the treatment of pest infestations.

42. The use of a carboxylic acid to stabilise a soluble liquid concentrate (SL) composition comprising: i) an oxime carbamate; and ii) a liquid carrier.

43. The use according to claim 42, wherein the carboxylic acid is an aliphatic carboxylic acid.

44. The use according to claim 42, wherein the carboxylic acid has from 1 to 8 carbon atoms.

45. The use according to claim 44, wherein the carboxylic acid is selected from formic acid, acetic acid, propionoic acid, butyric acid, valeric acid, caproic acid and benzoic acid.

46. The use according to claim 45, wherein the carboxylic acid is acetic acid.

47. The use according to claim 1, wherein the carboxylic acid is present in the composition in an amount to provide a pH of up to 6.5.

48. The use according to claim 47, wherein the composition has a pH of up to 4.0.

49. The use according to claim 48, wherein the composition has a pH of from 3.0 to 4.0.

50. The use according to claim 1, wherein the carboxylic acid is present in the composition an amount of from 0.5 to 5% by weight.

Description

DETAILED DESCRIPTION

EXAMPLES

Example 1

[0084] A soluble concentrate (SL) formulation was prepared by mixing the following components:

TABLE-US-00001 Oxamyl (97.5% TG) 43.0% Methanol 20.0% Propylene carbonate 15.0% Acetic acid 1.0% Brilliant blue FCF (Dye) 0.002% Tartrazine (Dye) 0.0002% Water to 100%

[0085] The formulation had a pH of about 3.5. The formulation exhibited excellent stability.

Example 2

[0086] A soluble concentrate (SL) formulation was prepared by mixing the following components:

TABLE-US-00002 Oxamyl (97.5% TG) 24.6% Methanol 20.0% Propylene carbonate 9.0% Acetic acid 1.0% Brilliant blue FCF (Dye) 0.03% Tartrazine (Dye) 0.07% Water to 100%

[0087] The formulation had a pH of about 3.5. The formulation exhibited excellent stability.

Field Test Examples

[0088] The compositions of Examples 1 and 2 were dispersed in water to form a diluted spray medium. The spray medium was sprayed on plants at a locus.

[0089] The compositions of Examples 1 and 2 were readily compatible with water and easily dispersed in water to form the spray medium. The spray medium was readily sprayed using standard spray equipment with no indication of any instability of the active components of the composition, which remained in solution.

Stability Test 1

[0090] Soluble liquid (SL) formulations 3 to 7 and Comparative formulation A were prepared as described above having the compositions summarised in Table 1 below.

TABLE-US-00003 TABLE 1 Comparative Example Example Example Example Example Example Component A 3 4 5 6 7 Oxamyl (%) 24 24 24 24 24 24 Boric Acid (%) 1 Acetic Acid (%) 1 Citric Acid (%) 1 Phosphoric Acid (%) 1 Hydrochloric Acid (%) 1 Methanol (%) 40 40 40 40 40 40 Propylene Carbamate (%) 10 10 10 10 10 10 Water (%) 25 25 25 25 25 25

[0091] Samples of the compositions summarised in Table 1 above were packaged in commercially available 500 ml fluorinated plastic bottles and the bottles sealed. The bottles were stored at 54 C. for 14 days. Thereafter, the bottles were cooled to room temperature and their appearance assessed. The concentration of the active ingredient, oxamyl, in each bottle was measured.

[0092] The results are set out in Table 2 below.

TABLE-US-00004 TABLE 2 Oxamyl content after Observed storage at Degradation packaging 54 C. of oxamyl bottle pH (%) (%) flatulence Comparative 6.63 18.8 21.7 Serious Example A Example 3 6.52 18.5 22.6 Serious Example 4 3.67 23.5 2.08 None Example 5 3.55 23.6 2.07 Medium Example 6 3.50 23.4 2.09 Medium Example 7 3.40 23.4 2.50 Medium

[0093] From the results set out in Table 2 above, it can be seen that boric acid was not effective in stabilising the oxamyl active ingredient and did not prevent packaging bottle flatulence. The presence of citric acid, phosphoric acid and hydrochloric acid in the compositions significantly reduced the chemical degradation of the oxamyl active ingredient. However, the compositions containing these acids exhibited packaging bottle flatulence, as evidenced by observed deformation of the bottle. Acetic acid present in the composition significantly reduced the chemical degradation of oxamyl and also eliminated all observable packaging bottle flatulence.

Stability Test 2

[0094] Soluble liquid (SL) formulations 8 to 15 were prepared as described above having the compositions summarised in Table 3 below.

TABLE-US-00005 TABLE 3 Example Example Example Example Example Example Example Example 8 9 10 11 12 13 14 15 Oxamyl (%) 24 24 24 24 24 24 24 24 Acetic Acid (%) 1 1 1 1 1 1 2 3 Methanol (%) 50 10 50 10 5 35 15 15 Propylene Carbonate (%) 5 5 15 15 35 35 15 15 Water (%) 20 60 10 50 35 5 9 8

[0095] Samples of the compositions summarised in Table 3 above were packaged in commercially available 500 ml fluorinated plastic bottles and the bottles sealed. The bottles were stored at 54 C. for 14 days. Thereafter, the bottles were cooled to room temperature and their appearance assessed. The concentration of the active ingredient, oxamyl, in each bottle was measured.

[0096] The results are set out in Table 4 below.

TABLE-US-00006 TABLE 4 Oxamyl content after Observed storage at Degradation packaging 54 C. of oxamyl bottle pH (%) (%) flatulence Example 8 3.65 23.8 1.24 None Example 9 3.69 23.2 2.11 None Example 10 3.65 24.0 1.64 None Example 11 3.66 23.4 1.69 None Example 12 3.63 23.8 2.06 None Example 13 3.62 23.5 1.67 None Example 14 3.43 23.9 1.24 None Example 15 3.20 23.6 2.07 None

[0097] From the data set out in Table 4, it can be seen that the compositions comprising acetic acid exhibited a very high level of stability of the oxamyl active ingredient. In addition, the presence of acetic acid prevented the occurrence of packaging bottle flatulence.