ORAL COMPOSITION FOR TOOTH WHITENING PRODUCT, AND KIT COMPRISING SAME

Abstract

The present invention relates to a composition that acts prior to the action of a tooth whitening composition or tooth whitening patch, the composition containing an oral cavity stimulation alleviating component able to reduce stimulation by the tooth whitening composition or patch. The present invention also relates to a tooth whitening kit whereby oral cavity stimulation is alleviated. The composition that acts prior to the action of a tooth whitening composition or patch of the present invention provides an outstanding tooth whitening effect while alleviating pain by mitigating intra-oral stimulation brought about by the rapid action of a tooth whitening component due to a tooth whitening component active agent.

Claims

1.-20. (canceled)

21. A method of whitening tooth, comprising: applying first agent containing an oral irritation mitigating ingredient and tooth whitening ingredient activator; and applying second agent containing a tooth whitening ingredient and a peroxide stabilizer after applying the first agent.

22. The method according to claim 21, wherein the oral irritation mitigating ingredient is at least one selected from the group consisting of: amino acids including methionine, cysteine and taurine; organic acids including ursodeoxycholic acid and tauroursodeoxycholic acid; and vitamins including vitamins A, C and E.

23. The method according to claim 22, wherein the oral irritation mitigating ingredient is taurine.

24. The method according to claim 21, wherein the tooth whitening ingredient is at least one selected from hydrogen peroxide, carbamide peroxide, calcium peroxide, tetrasodium pyrophosphate peroxidate, sodium bicarbonate and a chloride-based bleaching agent.

25. The method according to claim 21, wherein the tooth whitening ingredient activator is at least one selected from divalent or trivalent metal catalyst, a pH adjuster or mixtures thereof.

26. The method according to claim 21, wherein the oral irritation mitigating ingredient is present in an amount of 0.001 wt % to 10 wt % per the total weight of the first agent.

27. The method according to claim 21, wherein the first agent is in gel formulation, and the second agent is in patch form.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0068] FIG. 1 is a graph showing variations in tooth brightness after the use of a kit for tooth whitening according to the present disclosure.

[0069] FIG. 2 is a graph showing the degree of skin irritation.

[0070] FIG. 3 is a graph showing survey evaluation results of the degree of irritation.

[0071] FIG. 4 is a graph showing measured variations relative to initial brightness of tooth samples.

BEST MODE

[0072] Hereinafter, the present disclosure will be described in detail through the following embodiments. However, the embodiments according to the present disclosure may be modified in many different forms, and the scope of the present disclosure shall not be construed as being limited to the embodiments mentioned below. The embodiments of the present disclosure are provided for illustration to help a full understanding of the present disclosure.

Examples 1-4 and Comparative Examples 1-2

[0073] A tooth whitening kit according to the present disclosure was produced by a general method in the art according to the ingredient ratios as shown in the following Table 1. The amount unit in the following Table 1 is wt %.

TABLE-US-00001 TABLE 1 Comparative Comparative example 1 example 2 Example 1 Example 2 Example 3 Example 4 First agent — — Iron chloride Iron chloride Iron chloride Iron chloride (gel 0.5% 0.5% 0.5% 0.5% formulation) Taurine VitE 0.2% UDCA 0.2% efficacy 0.2% material First agent Glycerin Glycerin 5% Glycerin 5% Glycerin 5% Glycerin 5% Glycerin 5% (gel 5% formulation) Silica 10% Silica 10% Silica 10% Silica 10% Silica 10% Silica 10% additive Povidone Povidone Povidone Povidone Povidone Povidone 10% material 10% 10% 10% 10% 10% Ethanol Ethanol 10% Ethanol 10% Ethanol 10% Ethanol 10% Ethanol 10% 10% Water to Water to Water to Water to Water to Water to 100% 100% 100% 100% 100% 100% Second agent — Hydrogen Hydrogen Hydrogen Hydrogen Hydrogen (patch) peroxide peroxide peroxide peroxide peroxide 3.0% efficacy 3.0% 3.0% 3.0% 3.0% material

Experimental Example 1

Whitening Effect Test-Brightness Variation

[0074] 1) Test Method.

[0075] Comparative example 2 and examples 1 and 2 were each attached to a stained HAP disk and then removed after 1 hour, and variations relative to initial brightness were measured.

[0076] 2) Test Results

[0077] The results are shown in FIG. 1. As shown in FIG. 1, it could be seen that examples 1 and 2 showed an improvement in whitening effect by about 70% or more as compared to comparative example 2 using hydrogen peroxide alone.

Experimental Example 2

Patch Test Related to Irritation

[0078] 1) Test Method

[0079] 11 men having no skin disease on their arms were selected and comparative examples and examples were applied/attached in size of 2.5 cm×2.5 cm and kept for 1 hour. After removal in 1 hour, the remaining gel formulation was washed off with flowing water, and after 30 minutes, the degree of skin irritation was determined in accordance with the following judgment standard.

[0080] <Judgment Standard>

[0081] (CTFA/ICDRG Guideline, Textbook of Contact Dermatitis)

TABLE-US-00002 TABLE 2 Reaction Score Symptoms and determination criteria −+/−++++++ 00.51.02.03.0 No reaction Mild redness Moderate redness Serious redness involving swelling Serious redness involving blistering and swelling

[0082] 2) Test Results

[0083] According to the results shown in FIG. 2, as a result of determining the degree of skin irritation, it could be seen that a skin irritation phenomenon was remarkably reduced in examples 2 through 4, compared to comparative examples 1 and 2. Particularly, it was found that example 2 containing taurine among the skin irritation mitigating ingredients showed a lowest degree of skin irritation.

[0084] Furthermore, it was demonstrated through experimentation that when the whitening ingredient activator is not used with the skin irritation mitigating ingredient, even stronger skin irritation might occur as compared to comparative examples 1 and 2.

[0085] Accordingly, when putting the results of experimental examples 1 and 2 together, the fact could be recognized that when the whitening ingredient activator is used with the skin irritation mitigating ingredient, an excellent tooth whitening effect could be obtained without causing irritation on the gum.

Experimental Example 3

Survey Evaluation Related to Irritation

[0086] After using comparative example 2 and examples 1 and 2, each subject was allowed to evaluate the degree of irritation on a 3-point scale according to the following evaluation criteria.

[0087] <Evaluation Criteria>

[0088] 0: No irritation

[0089] 1: Mild irritation

[0090] 2: Certainly sensible irritation.

[0091] 3: Stop using due to irritation

[0092] According to the results shown in FIG. 3, it could be seen that in the case where iron chloride was used, the feeling of irritation was found more severe than the case where iron chloride was not used, but in the case where taurine was contained, the degree of feeling of skin irritation was significantly reduced.

[0093] The survey evaluation results showed that skin irritation was alleviated by taurine similar to the patch test related to irritation of experimental example 2.

Example 5 and Comparative Examples 3-8

[0094] The kit for tooth whitening according to the present disclosure was produced according to the ingredient ratios as shown in the following Table 3, and the unit was indicated in wt %.

[0095] The gel formulation of the present disclosure was prepared by the following process.

[0096] After silica as an abrasive and iron chloride as an efficacy material were dissolved in a mixed solution of ethanol and water, povidone was added thereto, followed by stirring for 20 minutes.

[0097] The comparative example was prepared by the same method as example except the ingredients added.

[0098] After dissolving iron chloride in water, ethanol and silica were introduced, and when silica was found to be fully dispersed, povidone was introduced, followed by stirring for 20 minutes.

[0099] In addition, the patch for tooth whitening that is attached to the tooth included hydrogen peroxide as a whitening ingredient as shown below, and was produced in the same way as example 2 of U.S. Pat. No. 6,682,721.

TABLE-US-00003 TABLE 3 Comparative Comparative Comparative Comparative Comparative Comparative example 3 example 4 example 5 example 6 example 7 example 8 Example 5 First agent — Ferrous Ferrous Magnesium Manganesm Iron sulfate Iron chloride (gel gluconate lactate chloride chloride 0.5% 0.5% formulation) 0.5% 0.5% 0.5% 0.5% efficacy material First agent Glycerin Glycerin Glycerin Glycerin Glycerin Glycerin Glycerin 5% (gel 5% 5% 5% 5% 5% 5% formulation) Silica 10% Silica 10% Silica 10% Silica 10% Silica 10% Silica 10% Silica 10% additive Povidone Povidone Povidone Povidone Povidone Povidone Povidone material 10% 10% 10% 10% 10% 10% 10% Ethanol Ethanol Ethanol Ethanol Ethanol Ethanol Ethanol 10% 10% 10% 10% 10% 10% 10% Water to Water to Water to Water to Water to Water to Water to 100% 100% 100% 100% 100% 100% 100% Second Hydrogen Hydrogen Hydrogen Hydrogen Hydrogen Hydrogen Hydrogen agent peroxide peroxide peroxide peroxide peroxide peroxide peroxide (patch) 3.0% 3.0% 3.0% 3.0% 3.0% 3.0% 3.0% efficacy material

Experimental Example 4

Brightness Variation

[0100] 1) Test Method

[0101] Comparative examples 3 through 8 and example 5 were each attached to a stained HAP disk and were removed after 1 hour, and variations relative to initial brightness were measured and were indicated as ΔL.

[0102] 2) Test Results

[0103] It could be seen that the gel formulation containing the metal salt catalyst (comparative examples 3 through 8 and example 5) showed a higher whitening effect than comparative example 3 using the gel formulation with no efficacy material, and among them, the effect of example 5 using iron chloride was prominent. That is, it was demonstrated through experimentation that the composition containing iron chloride had a highest tooth whitening effect, and the results were shown in FIG. 4. The unit on the vertical axis of FIG. 4 was ΔL.