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Antibody Constructs For CDH19 and CD3

20180002450 · 2018-01-04

    Inventors

    Cpc classification

    International classification

    Abstract

    The present invention provides to a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

    Claims

    1-14. (canceled)

    15. A method for treating or ameliorating a melanoma disease, comprising the step of administering to a subject in need thereof a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell, wherein the first binding domain comprises a VH region comprising CDR-H1, CDR-H2 and CDR-H3 and a VL region comprising CDR-L1, CDR-L2 and CDR-L3 selected from the group consisting of: (a)(i) CDR-H1 as set forth in SEQ ID NO: 14, CDR-H2 as set forth in SEQ ID NO: 15, CDR-H3 as set forth in SEQ ID NO: 16, CDR-L1 as set forth in SEQ ID NO: 17, CDR-L2 as set forth in SEQ ID NO: 18 and CDR-L3 as set forth in SEQ ID NO: 19; (a)(ii) CDR-H1 as set forth in SEQ ID NO: 27, CDR-H2 as set forth in SEQ ID NO: 28, CDR-H3 as set forth in SEQ ID NO: 29, CDR-L1 as set forth in SEQ ID NO: 30, CDR-L2 as set forth in SEQ ID NO: 31 and CDR-L3 as set forth in SEQ ID NO: 32; (a)(iii) CDR-H1 as set forth in SEQ ID NO: 40, CDR-H2 as set forth in SEQ ID NO: 41, CDR-H3 as set forth in SEQ ID NO: 42, CDR-L1 as set forth in SEQ ID NO: 43, CDR-L2 as set forth in SEQ ID NO: 44 and CDR-L3 as set forth in SEQ ID NO: 45; (a)(iv) CDR-H1 as set forth in SEQ ID NO: 53, CDR-H2 as set forth in SEQ ID NO: 54, CDR-H3 as set forth in SEQ ID NO: 55, CDR-L1 as set forth in SEQ ID NO: 56, CDR-L2 as set forth in SEQ ID NO: 57 and CDR-L3 as set forth in SEQ ID NO: 58; (a)(v) CDR-H1 as set forth in SEQ ID NO: 66, CDR-H2 as set forth in SEQ ID NO: 67, CDR-H3 as set forth in SEQ ID NO: 68, CDR-L1 as set forth in SEQ ID NO: 69, CDR-L2 as set forth in SEQ ID NO: 70 and CDR-L3 as set forth in SEQ ID NO: 71; (a)(vi) CDR-H1 as set forth in SEQ ID NO: 79, CDR-H2 as set forth in SEQ ID NO: 80, CDR-H3 as set forth in SEQ ID NO: 81, CDR-L1 as set forth in SEQ ID NO: 82, CDR-L2 as set forth in SEQ ID NO: 83 and CDR-L3 as set forth in SEQ ID NO: 84; (a)(vii) CDR-H1 as set forth in SEQ ID NO: 92, CDR-H2 as set forth in SEQ ID NO: 93, CDR-H3 as set forth in SEQ ID NO: 94, CDR-L1 as set forth in SEQ ID NO: 95, CDR-L2 as set forth in SEQ ID NO: 96 and CDR-L3 as set forth in SEQ ID NO: 97; (a)(viii) CDR-H1 as set forth in SEQ ID NO: 105, CDR-H2 as set forth in SEQ ID NO: 106, CDR-H3 as set forth in SEQ ID NO: 107, CDR-L1 as set forth in SEQ ID NO: 108, CDR-L2 as set forth in SEQ ID NO: 109 and CDR-L3 as set forth in SEQ ID NO: 110; (a)(ix) CDR-H1 as set forth in SEQ ID NO: 118, CDR-H2 as set forth in SEQ ID NO: 119, CDR-H3 as set forth in SEQ ID NO: 120, CDR-L1 as set forth in SEQ ID NO: 121, CDR-L2 as set forth in SEQ ID NO: 122 and CDR-L3 as set forth in SEQ ID NO: 123; (a)(x) CDR-H1 as set forth in SEQ ID NO: 131, CDR-H2 as set forth in SEQ ID NO: 132, CDR-H3 as set forth in SEQ ID NO: 133, CDR-L1 as set forth in SEQ ID NO: 134, CDR-L2 as set forth in SEQ ID NO: 135 and CDR-L3 as set forth in SEQ ID NO: 136; (a)(xi) CDR-H1 as set forth in SEQ ID NO: 144, CDR-H2 as set forth in SEQ ID NO: 145, CDR-H3 as set forth in SEQ ID NO: 146, CDR-L1 as set forth in SEQ ID NO: 147, CDR-L2 as set forth in SEQ ID NO: 148 and CDR-L3 as set forth in SEQ ID NO: 149; (a)(xii) CDR-H1 as set forth in SEQ ID NO: 157, CDR-H2 as set forth in SEQ ID NO: 158, CDR-H3 as set forth in SEQ ID NO: 159, CDR-L1 as set forth in SEQ ID NO: 160, CDR-L2 as set forth in SEQ ID NO: 161 and CDR-L3 as set forth in SEQ ID NO: 162, (a)(xiii) CDR-H1 as set forth in SEQ ID NO: 170, CDR-H2 as set forth in SEQ ID NO: 171, CDR-H3 as set forth in SEQ ID NO: 172, CDR-L1 as set forth in SEQ ID NO: 173, CDR-L2 as set forth in SEQ ID NO: 174 and CDR-L3 as set forth in SEQ ID NO: 175; (a)(xiv) CDR-H1 as set forth in SEQ ID NO: 183, CDR-H2 as set forth in SEQ ID NO: 184, CDR-H3 as set forth in SEQ ID NO: 185, CDR-L1 as set forth in SEQ ID NO: 186, CDR-L2 as set forth in SEQ ID NO: 187 and CDR-L3 as set forth in SEQ ID NO: 188; (a)(xv) CDR-H1 as set forth in SEQ ID NO: 196, CDR-H2 as set forth in SEQ ID NO: 197, CDR-H3 as set forth in SEQ ID NO: 198, CDR-L1 as set forth in SEQ ID NO: 199, CDR-L2 as set forth in SEQ ID NO: 200 and CDR-L3 as set forth in SEQ ID NO: 201; (a)(xvi) CDR-H1 as set forth in SEQ ID NO: 209, CDR-H2 as set forth in SEQ ID NO: 210, CDR-H3 as set forth in SEQ ID NO: 211, CDR-L1 as set forth in SEQ ID NO: 212, CDR-L2 as set forth in SEQ ID NO: 213 and CDR-L3 as set forth in SEQ ID NO: 214; (a)(xvii) CDR-H1 as set forth in SEQ ID NO: 222, CDR-H2 as set forth in SEQ ID NO: 223, CDR-H3 as set forth in SEQ ID NO: 224, CDR-L1 as set forth in SEQ ID NO: 225, CDR-L2 as set forth in SEQ ID NO: 226 and CDR-L3 as set forth in SEQ ID NO: 227; (a)(xviii) CDR-H1 as set forth in SEQ ID NO: 235, CDR-H2 as set forth in SEQ ID NO: 236, CDR-H3 as set forth in SEQ ID NO: 237, CDR-L1 as set forth in SEQ ID NO: 238, CDR-L2 as set forth in SEQ ID NO: 239 and CDR-L3 as set forth in SEQ ID NO: 240; (a)(xix) CDR-H1 as set forth in SEQ ID NO: 248, CDR-H2 as set forth in SEQ ID NO: 249, CDR-H3 as set forth in SEQ ID NO: 250, CDR-L1 as set forth in SEQ ID NO: 251, CDR-L2 as set forth in SEQ ID NO: 252 and CDR-L3 as set forth in SEQ ID NO: 253; (a)(xx) CDR-H1 as set forth in SEQ ID NO: 261, CDR-H2 as set forth in SEQ ID NO: 262, CDR-H3 as set forth in SEQ ID NO: 263, CDR-L1 as set forth in SEQ ID NO: 264, CDR-L2 as set forth in SEQ ID NO: 265 and CDR-L3 as set forth in SEQ ID NO: 266; (a)(xxi) CDR-H1 as set forth in SEQ ID NO: 274, CDR-H2 as set forth in SEQ ID NO: 275, CDR-H3 as set forth in SEQ ID NO: 276, CDR-L1 as set forth in SEQ ID NO: 277, CDR-L2 as set forth in SEQ ID NO: 278 and CDR-L3 as set forth in SEQ ID NO: 279; (a)(xxii) CDR-H1 as set forth in SEQ ID NO: 287, CDR-H2 as set forth in SEQ ID NO: 288, CDR-H3 as set forth in SEQ ID NO: 289, CDR-L1 as set forth in SEQ ID NO: 290, CDR-L2 as set forth in SEQ ID NO: 291 and CDR-L3 as set forth in SEQ ID NO: 292; (a)(xxiii) CDR-H1 as set forth in SEQ ID NO: 300, CDR-H2 as set forth in SEQ ID NO: 301, CDR-H3 as set forth in SEQ ID NO: 302, CDR-L1 as set forth in SEQ ID NO: 303, CDR-L2 as set forth in SEQ ID NO: 304 and CDR-L3 as set forth in SEQ ID NO: 305; (a)(xxiv) CDR-H1 as set forth in SEQ ID NO: 313, CDR-H2 as set forth in SEQ ID NO: 314, CDR-H3 as set forth in SEQ ID NO: 315, CDR-L1 as set forth in SEQ ID NO: 316, CDR-L2 as set forth in SEQ ID NO: 317 and CDR-L3 as set forth in SEQ ID NO: 318; (b)(i) CDR-H1 as set forth in SEQ ID NO: 508, CDR-H2 as set forth in SEQ ID NO: 509, CDR-H3 as set forth in SEQ ID NO: 510, CDR-L1 as set forth in SEQ ID NO: 511, CDR-L2 as set forth in SEQ ID NO: 512 and CDR-L3 as set forth in SEQ ID NO: 513; (b)(ii) CDR-H1 as set forth in SEQ ID NO: 521, CDR-H2 as set forth in SEQ ID NO: 522, CDR-H3 as set forth in SEQ ID NO: 523, CDR-L1 as set forth in SEQ ID NO: 524, CDR-L2 as set forth in SEQ ID NO: 525 and CDR-L3 as set forth in SEQ ID NO: 526; (b)(iii) CDR-H1 as set forth in SEQ ID NO: 534, CDR-H2 as set forth in SEQ ID NO: 535, CDR-H3 as set forth in SEQ ID NO: 536, CDR-L1 as set forth in SEQ ID NO: 537, CDR-L2 as set forth in SEQ ID NO: 538 and CDR-L3 as set forth in SEQ ID NO: 539; (b)(iv) CDR-H1 as set forth in SEQ ID NO: 547, CDR-H2 as set forth in SEQ ID NO: 548, CDR-H3 as set forth in SEQ ID NO: 549, CDR-L1 as set forth in SEQ ID NO: 550, CDR-L2 as set forth in SEQ ID NO: 551 and CDR-L3 as set forth in SEQ ID NO: 552; (b)(v) CDR-H1 as set forth in SEQ ID NO: 560, CDR-H2 as set forth in SEQ ID NO: 561, CDR-H3 as set forth in SEQ ID NO: 562, CDR-L1 as set forth in SEQ ID NO: 563, CDR-L2 as set forth in SEQ ID NO: 564 and CDR-L3 as set forth in SEQ ID NO: 565; (b)(vi) CDR-H1 as set forth in SEQ ID NO: 573, CDR-H2 as set forth in SEQ ID NO: 574, CDR-H3 as set forth in SEQ ID NO: 575, CDR-L1 as set forth in SEQ ID NO: 576, CDR-L2 as set forth in SEQ ID NO: 577 and CDR-L3 as set forth in SEQ ID NO: 578; and (b)(vii) CDR-H1 as set forth in SEQ ID NO: 586 CDR-H2 as set forth in SEQ ID NO: 587, CDR-H3 as set forth in SEQ ID NO: 588, CDR-L1 as set forth in SEQ ID NO: 589, CDR-L2 as set forth in SEQ ID NO: 590 and CDR-L3 as set forth in SEQ ID NO: 591; and (b)(viii) CDR-H1 as set forth in SEQ ID NO: 1, CDR-H2 as set forth in SEQ ID NO: 2, CDR-H3 as set forth in SEQ ID NO: 3, CDR-L1 as set forth in SEQ ID NO: 4, CDR-L2 as set forth in SEQ ID NO: 5 and CDR-L3 as set forth in SEQ ID NO: 6; (b)(ix) CDR-H1 as set forth in SEQ ID NO: 326, CDR-H2 as set forth in SEQ ID NO: 327, CDR-H3 as set forth in SEQ ID NO: 328, CDR-L1 as set forth in SEQ ID NO: 329, CDR-L2 as set forth in SEQ ID NO: 330 and CDR-L3 as set forth in SEQ ID NO: 331; (b)(x) CDR-H1 as set forth in SEQ ID NO: 339, CDR-H2 as set forth in SEQ ID NO: 340, CDR-H3 as set forth in SEQ ID NO: 341, CDR-L1 as set forth in SEQ ID NO: 342, CDR-L2 as set forth in SEQ ID NO: 343 and CDR-L3 as set forth in SEQ ID NO: 344, (b)(xi) CDR-H1 as set forth in SEQ ID NO: 352, CDR-H2 as set forth in SEQ ID NO: 353, CDR-H3 as set forth in SEQ ID NO: 354, CDR-L1 as set forth in SEQ ID NO: 355, CDR-L2 as set forth in SEQ ID NO: 356 and CDR-L3 as set forth in SEQ ID NO: 357; (b)(xii) CDR-H1 as set forth in SEQ ID NO: 365, CDR-H2 as set forth in SEQ ID NO: 366, CDR-H3 as set forth in SEQ ID NO: 367, CDR-L1 as set forth in SEQ ID NO: 368, CDR-L2 as set forth in SEQ ID NO: 369 and CDR-L3 as set forth in SEQ ID NO: 370; (b)(xiii) CDR-H1 as set forth in SEQ ID NO: 378, CDR-H2 as set forth in SEQ ID NO: 379, CDR-H3 as set forth in SEQ ID NO: 380, CDR-L1 as set forth in SEQ ID NO: 381, CDR-L2 as set forth in SEQ ID NO: 382 and CDR-L3 as set forth in SEQ ID NO: 383; (b)(xiv) CDR-H1 as set forth in SEQ ID NO: 391, CDR-H2 as set forth in SEQ ID NO: 392, CDR-H3 as set forth in SEQ ID NO: 393, CDR-L1 as set forth in SEQ ID NO: 394, CDR-L2 as set forth in SEQ ID NO: 395 and CDR-L3 as set forth in SEQ ID NO: 396; (b)(xv) CDR-H1 as set forth in SEQ ID NO: 404, CDR-H2 as set forth in SEQ ID NO: 405, CDR-H3 as set forth in SEQ ID NO: 406, CDR-L1 as set forth in SEQ ID NO: 407, CDR-L2 as set forth in SEQ ID NO: 408 and CDR-L3 as set forth in SEQ ID NO: 409; (b)(xvi) CDR-H1 as set forth in SEQ ID NO: 417, CDR-H2 as set forth in SEQ ID NO: 418, CDR-H3 as set forth in SEQ ID NO: 419, CDR-L1 as set forth in SEQ ID NO: 420, CDR-L2 as set forth in SEQ ID NO: 421 and CDR-L3 as set forth in SEQ ID NO: 422; (b)(xvii) CDR-H1 as set forth in SEQ ID NO: 430, CDR-H2 as set forth in SEQ ID NO: 431, CDR-H3 as set forth in SEQ ID NO: 432, CDR-L1 as set forth in SEQ ID NO: 433, CDR-L2 as set forth in SEQ ID NO: 434 and CDR-L3 as set forth in SEQ ID NO: 435; (b)(xviii) CDR-H1 as set forth in SEQ ID NO: 443, CDR-H2 as set forth in SEQ ID NO: 444, CDR-H3 as set forth in SEQ ID NO: 445, CDR-L1 as set forth in SEQ ID NO: 446, CDR-L2 as set forth in SEQ ID NO: 447 and CDR-L3 as set forth in SEQ ID NO: 448; (b)(xix) CDR-H1 as set forth in SEQ ID NO: 456, CDR-H2 as set forth in SEQ ID NO: 457, CDR-H3 as set forth in SEQ ID NO: 458, CDR-L1 as set forth in SEQ ID NO: 459, CDR-L2 as set forth in SEQ ID NO: 460 and CDR-L3 as set forth in SEQ ID NO: 461, (b)(xix) CDR-H1 as set forth in SEQ ID NO: 482, CDR-H2 as set forth in SEQ ID NO: 483, CDR-H3 as set forth in SEQ ID NO: 484, CDR-L1 as set forth in SEQ ID NO: 485, CDR-L2 as set forth in SEQ ID NO: 486 and CDR-L3 as set forth in SEQ ID NO: 487; (b)(xxi) CDR-H1 as set forth in SEQ ID NO: 495, CDR-H2 as set forth in SEQ ID NO: 496, CDR-H3 as set forth in SEQ ID NO: 497, CDR-L1 as set forth in SEQ ID NO: 498, CDR-L2 as set forth in SEQ ID NO: 499 and CDR-L3 as set forth in SEQ ID NO: 500; and (b)(xxii) CDR-H1 as set forth in SEQ ID NO: 599, CDR-H2 as set forth in SEQ ID NO: 600, CDR-H3 as set forth in SEQ ID NO: 601, CDR-L1 as set forth in SEQ ID NO: 602, CDR-L2 as set forth in SEQ ID NO: 603 and CDR-L3 as set forth in SEQ ID NO: 604.

    16. The method according to claim 15, wherein the melanoma disease is selected from the group consisting of superficial spreading melanoma, lentigo maligna, lentigo maligna melanoma, acral lentiginous melanoma, nodular melanoma, mucosal melanoma, desmoplastic melanoma, amelanotic melanoma, and soft tissue melanoma.

    17. (canceled)

    18. The method according to claim 15, wherein the melanoma disease is metastatic melanoma disease.

    19. The method according to claim 18, wherein the metastatic melanoma disease is selected from the group consisting of superficial spreading melanoma, lentigo maligna, lentigo maligna melanoma, acral lentiginous melanoma, nodular melanoma, mucosal melanoma, desmoplastic melanoma, amelanotic melanoma, and soft tissue melanoma.

    Description

    BRIEF DESCRIPTION OF THE DRAWINGS

    [0359] FIG. 1: Binding of CDH19 specific BiTE antibodies to human CDH19 expressing HEK293 cells. CHO cell culture supernatant was used as first step reagent for an immunofluorescence staining of human CDH19 expressing HEK293 cells, followed by detection with a mouse anti-His and a phycoerythrin-conjugated anti-mouse antibody. The fluorescence was determined by flow cytometry.

    [0360] FIG. 2: Binding of CDH19 specific BiTE antibodies to cynomolgus CDH19 expressing HEK293 cells. CHO cell culture supernatant was used as first step reagent for an immunofluorescence staining of cynomolgus CDH19 expressing HEK293 cells, followed by detection with a mouse anti-His and a phycoerythrin-conjugated anti-mouse antibody. The fluorescence was determined by flow cytometry.

    [0361] FIG. 3: Binding of CDH19 specific BiTE antibodies to untransfected HEK293 cells. CHO cell culture supernatant was used as first step reagent for an immunofluorescence staining of untransfected HEK293 cells, followed by detection with a mouse anti-His and a phycoerythrin-conjugated anti-mouse antibody. The fluorescence was determined by flow cytometry.

    [0362] FIG. 4: Binding of CDH19 specific BiTE antibodies to the cell line CHL-1. CHO cell culture supernatant was used as first step reagent for an immunofluorescence staining of CHL-1 cells, followed by detection with a mouse anti-His and a phycoerythrin-conjugated anti-mouse antibody. The fluorescence was determined by flow cytometry.

    [0363] FIG. 5: Human and/or chicken chimera constructs used for the Epitope Prediction for the CDH19 binding domains of the invention.

    A=huCDH19(44-772) (see SEQ ID NO: 1843)
    J=ckCDH19(44-776) (see SEQ ID NO: 1837)
    K=huCDH19(44-141)::ckCDH19(142-776) (see SEQ ID NO: 1838)
    L=ckCDH19(44-141)::huCDH19(142-249)::ckCDH19(250-776) (see SEQ ID NO: 1839)
    M=ckCDH19(44-249)::huCDH19(250-364)::ckCDH19(365-776) (see SEQ ID NO: 1840)
    N=ckCDH19(44-364)::huCDH19(365-463)::ckCDH19(469-776) (see SEQ ID NO: 1841)
    O=ckCDH19(44-468)::huCDH19(464-772) (see SEQ ID NO: 1842)

    [0364] FIG. 6: Epitope clustering of anti-CDH19 scFv shown by flowcytometry On chimeric chicken/human CDH19-constructs sharing representative examples of each epitope cluster found within the totality of tested CDH19-binders. HEK cells transfected with chicken or human CDH19, or with chimeric CDH19 molecules were used for epitope mapping of periplasmic extracts containing anti-human and macaque CDH19-scFv. Bound scFv were detected with an anti-HIS antibody and a PE-labeled anti-mouse Fc gamma-specific antibody. Left: designation of CDH19 scFv, top row: term of transfected HEK cells. Histogram figures: red box: gain of binding due to exchange of the chicken CDH19 sequence by the homologous human CDH19 sequence thus identifying the epitope or part of the epitope of the tested scFv. Abbreviations: wt: wildtype, hu: human, ck: chicken.

    [0365] It should be understood that the inventions herein are not limited to particular methodology, protocols, or reagents, as such can vary. The discussion and examples provided herein are presented for the purpose of describing particular embodiments only and are not intended to limit the scope of the present invention, which is defined solely by the claims.

    [0366] All publications and patents cited throughout the text of this specification (including all patents, patent applications, scientific publications, manufacturer's specifications, instructions, etc.), whether supra or infra, are hereby incorporated by reference in their entirety. Nothing herein is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention. To the extent the material incorporated by reference contradicts or is inconsistent with this specification, the specification will supersede any such material.

    EXAMPLES

    [0367] The following examples are provided for the purpose of illustrating specific embodiments or features of the present invention. These examples should not be construed as to limit the scope of this invention. The examples are included for purposes of illustration, and the present invention is limited only by the claims.

    Example 1

    [0368] Interspecies CDH19 Cross-Reactivity

    [0369] To confirm binding to human and cynomolgus CDH19, 46 different CDH19 BiTE antibodies were tested by flow cytometry using the following cell lines: i) HEK293 cells transfected with N-terminally FLAG-tagged human CDH19, ii) HEK293 cells transfected with N-terminally FLAG-tagged cynomolgus CDH19, iii) untransfected HEK293 cells, iv) the human melanoma cell line CHL-1 expressing native human CDH19 (Table 1).

    [0370] For flow cytometry 200,000 cells of the respective cell lines were incubated on ice for 30 min with 50 μl of CHO cell culture supernatant containing secreted BiTE molecules. Cell culture supernatant of untransfected cells was used as a negative control. The cells were washed twice in PBS/1% FCS/0.05% Na-Azide and binding of the constructs was detected with a murine anti-His antibody (clone AD1.1.10, AbD Serotec), diluted 1:1000 in 50 μl PBS/1% FCS/0.05% Na-Azide). After washing, bound anti-His antibodies were detected with a phycoerythrin-conjugated mouse Fc gamma-specific antibody (Dianova), diluted 1:100 in PBS/1% FCS/0.05% Na-Azide. Fluorescence signals of the cells were measured by flow cytometry on a FACSCanto II instrument and analyzed by FACSDiva software (both from Becton Dickinson).

    [0371] As a result, the CDH19/CD3 bispecific antibodies stained HEK293 cells transfected with human CDH19, cynomolgus CDH19 and the human CDH19-expressing melanoma cell line CHL-1. Moreover, no staining of untransfected HEK293 cells could be observed (see Figure—Figure). BiTE antibody 23 shows only weak binding to HEK293 cells expressing human CDH19 or cynomolgus CDH19 but clear binding to CHL-1 cells indicating a N-terminal CDH19 epitope which may be altered by the N-FLAG-tag of the recombinantly expressed CDH19 proteins on the respective transfected HEK293 cells.

    TABLE-US-00002 TABLE 1 CDH19 BiTE antibodies and assigned numbers. BiTE antibody BiTE antibody name number CH19_4-H8 1 CH19_6-A7 2 CH19_6-B8 3 CH19_6-C12 4 CH19_6-E12 5 CH19_6-F9 6 CH19_6-G8 7 CH19_4-A7 8 CH19_9-F1 9 CH19_9-F9 10 CH19_0-B4 11 CH19_0-C11 12 CH19_1-H8 13 CH19_2-E4 14 CH19_0-B8 15 CH19_0-C4 16 CH19_0-G4 17 CH19_0-H5 18 CH19_1-B12 19 CH19_1-D11 20 CH19_1-G11 21 CH19_1-H11 22 CH19_2-G6 23 CH19_5-G4 24 CH19_8-F6 25 CH19_0-G9 26 CH19_2-A10 27 CH19_2-D9 28 CH19_2-H7 29 CH19_0-E11 30 CH19_1-E11 31 CH19_8-H6 32 CH19_8-H7 33 CH19_9-C2 34 CH19_9-F3 35 CH19_0-F5 36 CH19_1-E1 37 CH19_1-E6 38 CH19_3-B10 39 CH19_3-F2 40 CH19_2-C11 41 CH19_3-D5 42 CH19_5-B3 43 CH19_5-E10 44 CH19_6-G10 45 CH19_203-VKG 46

    Example 2

    [0372] Cytotoxic Activity

    [0373] Target Cell Labeling

    [0374] For the analysis of cell lysis in flow cytometry assays, the fluorescent membrane dye DiOC18 (DiO) (Molecular Probes, #V22886) was used to label cynomolgus CDH19 positive CHO cells—as target cells and distinguish them from effector cells. Briefly, cells were harvested, washed once with PBS and adjusted to 106 cell/mL in PBS containing 2% (v/v) FBS and the membrane dye DiO (5 μL/106 cells). After incubation for 3 min at 37° C., cells were washed twice in complete RPMI medium and the cell number adjusted to 1.25×105 cells/mL. The vitality of cells was determined using 0.5% (v/v) isotonic EosinG solution (Roth, #45380).

    [0375] Flow Cytometry Based Analysis

    [0376] This assay was designed to quantify the lysis of cynomolgus CDH19-transfected CHO cells in the presence of serial dilutions of CDH19 bispecific antibodies.

    [0377] Equal volumes of DiO-labeled target cells and effector cells (i.e. CD3-expressing macaque T cell line 4119LnPx) were mixed, resulting in an E:T cell ratio of 10:1. 160 μL of this suspension were transferred to each well of a 96-well plate. 40 μL of serial dilutions of the CDH19 bispecific antibodies and a negative control bispecific (an CD3-based bispecific antibody recognizing an irrelevant target antigen) or RPMI complete medium as an additional negative control were added. The bispecific antibody-mediated cytotoxic reaction proceeded for 48 hours in a 7% CO2 humidified incubator. Then cells were transferred to a new 96-well plate and loss of target cell membrane integrity was monitored by adding propidium iodide (PI) at a final concentration of 1 μg/mL. PI is a membrane impermeable dye that normally is excluded from viable cells, whereas dead cells take it up and become identifiable by fluorescent emission.

    [0378] Samples were measured by flow cytometry on a FACSCanto II instrument and analyzed by FACSDiva software (both from Becton Dickinson).

    [0379] Target cells were identified as DiO-positive cells. PI-negative target cells were classified as living target cells. Percentage of cytotoxicity was calculated according to the following formula:

    [00001] Cytotoxicity .Math. [ % ] = n dead .Math. .Math. target .Math. .Math. cells n target .Math. .Math. cells × 100 n = number .Math. .Math. of .Math. .Math. events

    [0380] Using GraphPad Prism 6 software (Graph Pad Software, San Diego), the percentage of cytotoxicity was plotted against the corresponding bispecific antibody concentrations. Dose response curves were analyzed with the four parametric logistic regression models for evaluation of sigmoid dose response curves with fixed hill slope and EC50 values were calculated.

    Example 3

    [0381] Epitope Prediction by Human/Chicken Cadherin-19 Chimeras

    [0382] Domain binding was determined by flowcytometry on 293T cells transiently transfected with plasmids consisting of single human CDH19 cadherin repeat domain replacements into the chicken Cadherin19 backbone cloned into the pTT5 expression vector immediately preceded by native human or chicken CDH19 leader sequences and a Flag tag. The experiment included assaying a subset of anti-CDH19 antibodies against chicken Cadherin19 to determine suitability for binning on these human/chicken chimeras.

    [0383] The following binding assay was completed in 96-well V-bottom plates. 50,000 transiently transfected 293T cells were incubated with periplasmic extracts containing scFv binding to human and macaque CDH19. Bound scFv were detected with 1 μg/ml of a monoclonal mouse anti-HIS antibody (AbD Serotec MCA1396). After washing, bound anti-His antibodies were detected with a Fc gamma-specific antibody conjugated to phycoerythrin (Jackson-Immuno-Research 115-116-071) diluted 1:100.

    [0384] Cells were then washed one time and measured by flowcytometry on a FACS Calibur instrument (Becton Dickinson) and analyzed by FlowJo software (Version 7.6).

    [0385] The experiments included HEK 293 controls. As negative control, cells were incubated in PBS with 2% FCS instead of periplasmic extracts containing anti-CDH19 scFv.

    [0386] The FLAG tag was detected with 1 μg/ml of a FLAG M2 antibody (Sigma F1804) followed by a Fc gamma-specific antibody conjugated to phycoerythrin (Jackson-Immuno-Research 115-116-071).

    [0387] Antibodies used for this assay (anti-HIS antibody (AbD Serotec MCA1396), FLAG M2 antibody (Sigma F1804) and the PE-labeled Fc gamma-specific antibody (Jackson-Immuno-Research 115-116-071) were diluted in PBS with 2% FCS. Cells were incubated with the respective antibodies for 30 minutes at 4° C.

    [0388] The data from these experiments are presented in FIGS. 5 and 6. Table 2 summarises the conclusion of those assay for the antibody constructs of the invention.

    TABLE-US-00003 TABLE 2 Epitope Cluster prediction for CDH19 antibody constructs of the invention Epi- Epi- tope tope clus- clus- Clon ter Clon ter CH19_2G6_302_VKGxI2C6 E3 CH19_2-H7xI2C6 E1 CH19_0-E11xI2C6 E1 CH19_5-B3xI2C6 E3 CH19_5-G4xI2C6 E1 CH19_5-E10xI2C6 E3 CH19_8-H6xI2C6 E1 CH19_6-G10xI2C6 E3 CH19_2-C11xI2C6 E1 CH19_4-H8xI2C6 E3 CH19_2-A10xI2C6 E1 CH19_2-E4xI2C6 E3 CH19_1-D11xI2C6 E1 CH19_6-B8xI2C6 E3 CH19_9-F9xI2C6 E1 CH19_0-B4xI2C6 E3 CH19_1-H8xI2C6 E1 CH19_9-F1xI2C6 E3 CH19_1-B12xI2C6 E1 CH19_4-A7xI2C6 E3 CH19_0-C4xI2C6 E1 CH19_6-E12xI2C6 E3 CH19_3-F2xI2C6 E1 CH19_6-C12xI2C6 E3 CH19_3-B10xI2C6 E1 CH19_6-A7xI2C6 E3 CH19_0-G4xI2C6 E1 CH19_6-G8xI2C6 E3 CH19_0-H5xI2C6 E1 CH19_6-F9xI2C6 E3 CH19_0-B8xI2C6 E1 CH19_0-C11xI2C6 E1 CH19_2-D9xI2C6 E1 CH19_8-F6xI2C6 E1 CH19_8-H7xI2C6 E1 CH19_0-G9xI2C6 E1 CH19_9-C2xI2C6 E1 CH19_1-E11xI2C6 E1 CH19_3-D5xI2C6 E1 CH19_0-F5xI2C6 E1 CH19_1-G11xI2C6 E1 CH19_1-E1xI2C6 E1 CH19_1-H11xI2C6 E1 CH19_1-E6xI2C6 E1 CH19_9-F3xI2C6 E1 CH19_2G6_302xI2C6 E3 CH19_2-G6xI2C6 E1

    [0389] The following table provides sequence identifiers and descriptions for the sequences provided in the sequence listing (the table can be read by scrolling down each column and proceeding left-to-right across columns on a given page).

    TABLE-US-00004 Sequence Table Ab HCDR1 HCDR2 HCDR3 LCDR1 LCDR2 LCDR3 CH19_2G6_302_VKGxl2C6 (SEQ ID 1) (SEQ ID 2) (SEQ ID 3) (SEQ ID 4) (SEQ ID 5) (SEQ ID 6) CH19_0-E11xl2C6 (SEQ ID 14) (SEQ ID 15) (SEQ ID 16) (SEQ ID 17) (SEQ ID 18) (SEQ ID 19) CH19_5-G4xl2C6 (SEQ ID 27) (SEQ ID 28) (SEQ ID 29) (SEQ ID 30) (SEQ ID 31) (SEQ ID 32) CH19_8-H6xl2C6 (SEQ ID 40) (SEQ ID 41) (SEQ ID 42) (SEQ ID 43) (SEQ ID 44) (SEQ ID 45) CH19_2-C11xl2C6 (SEQ ID 53) (SEQ ID 54) (SEQ ID 55) (SEQ ID 56) (SEQ ID 57) (SEQ ID 58) CH19_2-A10xl2C6 (SEQ ID 66) (SEQ ID 67) (SEQ ID 68) (SEQ ID 69) (SEQ ID 70) (SEQ ID 71) CH19_1-D11xl2C6 (SEQ ID 79) (SEQ ID 80) (SEQ ID 81) (SEQ ID 82) (SEQ ID 83) (SEQ ID 84) CH19_9-F9xl2C6 (SEQ ID 92) (SEQ ID 93) (SEQ ID 94) (SEQ ID 95) (SEQ ID 96) (SEQ ID 97) CH19_1-H8xl2C6 (SEQ ID 105) (SEQ ID 106) (SEQ ID 107) (SEQ ID 108) (SEQ ID 109) (SEQ ID 110) CH19_1-B12xl2C6 (SEQ ID 118) (SEQ ID 119) (SEQ ID 120) (SEQ ID 121) (SEQ ID 122) (SEQ ID 123) CH19_0-C4xl2C6 (SEQ ID 131) (SEQ ID 132) (SEQ ID 133) (SEQ ID 134) (SEQ ID 135) (SEQ ID 136) CH19_3-F2xl2C6 (SEQ ID 144) (SEQ ID 145) (SEQ ID 146) (SEQ ID 147) (SEQ ID 148) (SEQ ID 149) CH19_3-B10xl2C6 (SEQ ID 157) (SEQ ID 158) (SEQ ID 159) (SEQ ID 160) (SEQ ID 161) (SEQ ID 162) CH19_0-G4xl2C6 (SEQ ID 170) (SEQ ID 171) (SEQ ID 172) (SEQ ID 173) (SEQ ID 174) (SEQ ID 175) CH19_0-H5xl2C6 (SEQ ID 183) (SEQ ID 184) (SEQ ID 185) (SEQ ID 186) (SEQ ID 187) (SEQ ID 188) CH19_0-B8xl2C6 (SEQ ID 196) (SEQ ID 197) (SEQ ID 198) (SEQ ID 199) (SEQ ID 200) (SEQ ID 201) CH19_2-D9xl2C6 (SEQ ID 209) (SEQ ID 210) (SEQ ID 211) (SEQ ID 212) (SEQ ID 213) (SEQ ID 214) CH19_8-H7xl2C6 (SEQ ID 222) (SEQ ID 223) (SEQ ID 224) (SEQ ID 225) (SEQ ID 226) (SEQ ID 227) CH19_9-C2xl2C6 (SEQ ID 235) (SEQ ID 236) (SEQ ID 237) (SEQ ID 238) (SEQ ID 239) (SEQ ID 240) CH19_3-D5xl2C6 (SEQ ID 248) (SEQ ID 249) (SEQ ID 250) (SEQ ID 251) (SEQ ID 252) (SEQ ID 253) CH19_1-G11xl2C6 (SEQ ID 261) (SEQ ID 262) (SEQ ID 263) (SEQ ID 264) (SEQ ID 265) (SEQ ID 266) CH19_1-H11xl2C6 (SEQ ID 274) (SEQ ID 275) (SEQ ID 276) (SEQ ID 277) (SEQ ID 278) (SEQ ID 279) CH19_9-F3xl2C6 (SEQ ID 287) (SEQ ID 288) (SEQ ID 289) (SEQ ID 290) (SEQ ID 291) (SEQ ID 292) CH19_2-G6xl2C6 (SEQ ID 300) (SEQ ID 301) (SEQ ID 302) (SEQ ID 303) (SEQ ID 304) (SEQ ID 305) CH19_2-H7xl2C6 (SEQ ID 313) (SEQ ID 314) (SEQ ID 315) (SEQ ID 316) (SEQ ID 317) (SEQ ID 318) CH19_5-B3xl2C6 (SEQ ID 326) (SEQ ID 327) (SEQ ID 328) (SEQ ID 329) (SEQ ID 330) (SEQ ID 331) CH19_5-E10xl2C6 (SEQ ID 339) (SEQ ID 340) (SEQ ID 341) (SEQ ID 342) (SEQ ID 343) (SEQ ID 344) CH19_6-G10xl2C6 (SEQ ID 352) (SEQ ID 353) (SEQ ID 354) (SEQ ID 355) (SEQ ID 356) (SEQ ID 357) CH19_4-H8xl2C6 (SEQ ID 365) (SEQ ID 366) (SEQ ID 367) (SEQ ID 368) (SEQ ID 369) (SEQ ID 370) CH19_2-E4xl2C6 (SEQ ID 378) (SEQ ID 379) (SEQ ID 380) (SEQ ID 381) (SEQ ID 382) (SEQ ID 383) CH19_6-B8xl2C6 (SEQ ID 391) (SEQ ID 392) (SEQ ID 393) (SEQ ID 394) (SEQ ID 395) (SEQ ID 396) CH19_0-B4xl2C6 (SEQ ID 404) (SEQ ID 405) (SEQ ID 406) (SEQ ID 407) (SEQ ID 408) (SEQ ID 409) CH19_9-F1xl2C6 (SEQ ID 417) (SEQ ID 418) (SEQ ID 419) (SEQ ID 420) (SEQ ID 421) (SEQ ID 422) CH19_4-A7xl2C6 (SEQ ID 430) (SEQ ID 431) (SEQ ID 432) (SEQ ID 433) (SEQ ID 434) (SEQ ID 435) CH19_6-E12xl2C6 (SEQ ID 443) (SEQ ID 444) (SEQ ID 445) (SEQ ID 446) (SEQ ID 447) (SEQ ID 448) CH19_6-C12xl2C6 (SEQ ID 456) (SEQ ID 457) (SEQ ID 458) (SEQ ID 459) (SEQ ID 460) (SEQ ID 461) CH19_6-A7xl2C6 (SEQ ID 469) (SEQ ID 470) (SEQ ID 471) (SEQ ID 472) (SEQ ID 473) (SEQ ID 474) CH19_6-G8xl2C6 (SEQ ID 482) (SEQ ID 483) (SEQ ID 484) (SEQ ID 485) (SEQ ID 486) (SEQ ID 487) CH19_6-F9xl2C6 (SEQ ID 495) (SEQ ID 496) (SEQ ID 497) (SEQ ID 498) (SEQ ID 499) (SEQ ID 500) CH19_0-C11xl2C6 (SEQ ID 508) (SEQ ID 509) (SEQ ID 510) (SEQ ID 511) (SEQ ID 512) (SEQ ID 513) CH19_8-F6xl2C6 (SEQ ID 521) (SEQ ID 522) (SEQ ID 523) (SEQ ID 524) (SEQ ID 525) (SEQ ID 526) CH19_0-G9xl2C6 (SEQ ID 534) (SEQ ID 535) (SEQ ID 536) (SEQ ID 537) (SEQ ID 538) (SEQ ID 539) CH19_1-E11xl2C6 (SEQ ID 547) (SEQ ID 548) (SEQ ID 549) (SEQ ID 550) (SEQ ID 551) (SEQ ID 552) CH19_0-F5xl2C6 (SEQ ID 560) (SEQ ID 561) (SEQ ID 562) (SEQ ID 563) (SEQ ID 564) (SEQ ID 565) CH19_1-E1xl2C6 (SEQ ID 573) (SEQ ID 574) (SEQ ID 575) (SEQ ID 576) (SEQ ID 577) (SEQ ID 578) CH19_1-E6xl2C6 (SEQ ID 586) (SEQ ID 587) (SEQ ID 588) (SEQ ID 589) (SEQ ID 590) (SEQ ID 591) CH19_2G6_302xl2C6 (SEQ ID 599) (SEQ ID 600) (SEQ ID 601) (SEQ ID 602) (SEQ ID 603) (SEQ ID 604) Ab LC V-region HC V-region CH19_2G6_302_VKGxl2C6 (SEQ ID 9) (SEQ ID 7) (SEQ ID 10) (SEQ ID 8) CH19_0-E11xl2C6 (SEQ ID 22) (SEQ ID 20) (SEQ ID 23) (SEQ ID 21) CH19_5-G4xl2C6 (SEQ ID 35) (SEQ ID 33) (SEQ ID 36) (SEQ ID 34) CH19_8-H6xl2C6 (SEQ ID 48) (SEQ ID 46) (SEQ ID 49) (SEQ ID 47) CH19_2-C11xl2C6 (SEQ ID 61) (SEQ ID 59) (SEQ ID 62) (SEQ ID 60) CH19_2-A10xl2C6 (SEQ ID 74) (SEQ ID 72) (SEQ ID 75) (SEQ ID 73) CH19_1-D11xl2C6 (SEQ ID 87) (SEQ ID 85) (SEQ ID 88) (SEQ ID 86) CH19_9-F9xl2C6 (SEQ ID 100) (SEQ ID 98) (SEQ ID 101) (SEQ ID 99) CH19_1-H8xl2C6 (SEQ ID 113) (SEQ ID 111) (SEQ ID 114) (SEQ ID 112) CH19_1-B12xl2C6 (SEQ ID 126) (SEQ ID 124) (SEQ ID 127) (SEQ ID 125) CH19_0-C4xl2C6 (SEQ ID 139) (SEQ ID 137) (SEQ ID 140) (SEQ ID 138) CH19_3-F2xl2C6 (SEQ ID 152) (SEQ ID 150) (SEQ ID 153) (SEQ ID 151) CH19_3-B10xl2C6 (SEQ ID 165) (SEQ ID 163) (SEQ ID 166) (SEQ ID 164) CH19_0-G4xl2C6 (SEQ ID 178) (SEQ ID 176) (SEQ ID 179) (SEQ ID 177) CH19_0-H5xl2C6 (SEQ ID 191) (SEQ ID 189) (SEQ ID 192) (SEQ ID 190) CH19_0-B8xl2C6 (SEQ ID 204) (SEQ ID 202) (SEQ ID 205) (SEQ ID 203) CH19_2-D9xl2C6 (SEQ ID 217) (SEQ ID 215) (SEQ ID 218) (SEQ ID 216) CH19_8-H7xl2C6 (SEQ ID 230) (SEQ ID 228) (SEQ ID 231) (SEQ ID 229) CH19_9-C2xl2C6 (SEQ ID 243) (SEQ ID 241) (SEQ ID 244) (SEQ ID 242) CH19_3-D5xl2C6 (SEQ ID 256) (SEQ ID 254) (SEQ ID 257) (SEQ ID 255) CH19_1-G11xl2C6 (SEQ ID 269) (SEQ ID 267) (SEQ ID 270) (SEQ ID 268) CH19_1-H11xl2C6 (SEQ ID 282) (SEQ ID 280) (SEQ ID 283) (SEQ ID 281) CH19_9-F3xl2C6 (SEQ ID 295) (SEQ ID 293) (SEQ ID 296) (SEQ ID 294) CH19_2-G6xl2C6 (SEQ ID 308) (SEQ ID 306) (SEQ ID 309) (SEQ ID 307) CH19_2-H7xl2C6 (SEQ ID 321) (SEQ ID 319) (SEQ ID 322) (SEQ ID 320) CH19_5-B3xl2C6 (SEQ ID 334) (SEQ ID 332) (SEQ ID 335) (SEQ ID 333) CH19_5-E10xl2C6 (SEQ ID 347) (SEQ ID 345) (SEQ ID 348) (SEQ ID 346) CH19_6-G10xl2C6 (SEQ ID 360) (SEQ ID 358) (SEQ ID 361) (SEQ ID 359) CH19_4-H8xl2C6 (SEQ ID 373) (SEQ ID 371) (SEQ ID 374) (SEQ ID 372) CH19_2-E4xl2C6 (SEQ ID 386) (SEQ ID 384) (SEQ ID 387) (SEQ ID 385) CH19_6-B8xl2C6 (SEQ ID 399) (SEQ ID 397) (SEQ ID 400) (SEQ ID 398) CH19_0-B4xl2C6 (SEQ ID 412) (SEQ ID 410) (SEQ ID 413) (SEQ ID 411) CH19_9-F1xl2C6 (SEQ ID 425) (SEQ ID 423) (SEQ ID 426) (SEQ ID 424) CH19_4-A7xl2C6 (SEQ ID 438) (SEQ ID 436) (SEQ ID 439) (SEQ ID 437) CH19_6-E12xl2C6 (SEQ ID 451) (SEQ ID 449) (SEQ ID 452) (SEQ ID 450) CH19_6-C12xl2C6 (SEQ ID 464) (SEQ ID 462) (SEQ ID 465) (SEQ ID 463) CH19_6-A7xl2C6 (SEQ ID 477) (SEQ ID 475) (SEQ ID 478) (SEQ ID 476) CH19_6-G8xl2C6 (SEQ ID 490) (SEQ ID 488) (SEQ ID 491) (SEQ ID 489) CH19_6-F9xl2C6 (SEQ ID 503) (SEQ ID 501) (SEQ ID 504) (SEQ ID 502) CH19_0-C11xl2C6 (SEQ ID 516) (SEQ ID 514) (SEQ ID 517) (SEQ ID 515) CH19_8-F6xl2C6 (SEQ ID 529) (SEQ ID 527) (SEQ ID 530) (SEQ ID 528) CH19_0-G9xl2C6 (SEQ ID 542) (SEQ ID 540) (SEQ ID 543) (SEQ ID 541) CH19_1-E11xl2C6 (SEQ ID 555) (SEQ ID 553) (SEQ ID 556) (SEQ ID 554) CH19_0-F5xl2C6 (SEQ ID 568) (SEQ ID 566) (SEQ ID 569) (SEQ ID 567) CH19_1-E1xl2C6 (SEQ ID 581) (SEQ ID 579) (SEQ ID 582) (SEQ ID 580) CH19_1-E6xl2C6 (SEQ ID 594) (SEQ ID 592) (SEQ ID 595) (SEQ ID 593) CH19_2G6_302xl2C6 (SEQ ID 607) (SEQ ID 605) (SEQ ID 608) (SEQ ID 606) Ab VH − VL CH19_2G6_302_VKGxl2C6 (SEQ ID 11) (SEQ ID 12) CH19_0-E11xl2C6 (SEQ ID 24) (SEQ ID 25) CH19_5-G4xl2C6 (SEQ ID 37) (SEQ ID 38) CH19_8-H6xl2C6 (SEQ ID 50) (SEQ ID 51) CH19_2-C11xl2C6 (SEQ ID 63) (SEQ ID 64) CH19_2-A10xl2C6 (SEQ ID 76) (SEQ ID 77) CH19_1-D11xl2C6 (SEQ ID 89) (SEQ ID 90) CH19_9-F9xl2C6 (SEQ ID 102) (SEQ ID 103) CH19_1-H8xl2C6 (SEQ ID 115) (SEQ ID 116) CH19_1-B12xl2C6 (SEQ ID 128) (SEQ ID 129) CH19_0-C4xl2C6 (SEQ ID 141) (SEQ ID 142) CH19_3-F2xl2C6 (SEQ ID 154) (SEQ ID 155) CH19_3-B10xl2C6 (SEQ ID 167) (SEQ ID 168) CH19_0-G4xl2C6 (SEQ ID 180) (SEQ ID 181) CH19_0-H5xl2C6 (SEQ ID 193) (SEQ ID 194) CH19_0-B8xl2C6 (SEQ ID 206) (SEQ ID 207) CH19_2-D9xl2C6 (SEQ ID 219) (SEQ ID 220) CH19_8-H7xl2C6 (SEQ ID 232) (SEQ ID 233) CH19_9-C2xl2C6 (SEQ ID 245) (SEQ ID 246) CH19_3-D5xl2C6 (SEQ ID 258) (SEQ ID 259) CH19_1-G11xl2C6 (SEQ ID 271) (SEQ ID 272) CH19_1-H11xl2C6 (SEQ ID 284) (SEQ ID 285) CH19_9-F3xl2C6 (SEQ ID 297) (SEQ ID 298) CH19_2-G6xl2C6 (SEQ ID 310) (SEQ ID 311) CH19_2-H7xl2C6 (SEQ ID 323) (SEQ ID 324) CH19_5-B3xl2C6 (SEQ ID 336) (SEQ ID 337) CH19_5-E10xl2C6 (SEQ ID 349) (SEQ ID 350) CH19_6-G10xl2C6 (SEQ ID 362) (SEQ ID 363) CH19_4-H8xl2C6 (SEQ ID 375) (SEQ ID 376) CH19_2-E4xl2C6 (SEQ ID 388) (SEQ ID 389) CH19_6-B8xl2C6 (SEQ ID 401) (SEQ ID 402) CH19_0-B4xl2C6 (SEQ ID 414) (SEQ ID 415) CH19_9-F1xl2C6 (SEQ ID 427) (SEQ ID 428) CH19_4-A7xl2C6 (SEQ ID 440) (SEQ ID 441) CH19_6-E12xl2C6 (SEQ ID 453) (SEQ ID 454) CH19_6-C12xl2C6 (SEQ ID 466) (SEQ ID 467) CH19_6-A7xl2C6 (SEQ ID 479) (SEQ ID 480) CH19_6-G8xl2C6 (SEQ ID 492) (SEQ ID 493) CH19_6-F9xl2C6 (SEQ ID 505) (SEQ ID 506) CH19_0-C11xl2C6 (SEQ ID 518) (SEQ ID 519) CH19_8-F6xl2C6 (SEQ ID 531) (SEQ ID 532) CH19_0-G9xl2C6 (SEQ ID 544) (SEQ ID 545) CH19_1-E11xl2C6 (SEQ ID 557) (SEQ ID 558) CH19_0-F5xl2C6 (SEQ ID 570) (SEQ ID 571) CH19_1-E1xl2C6 (SEQ ID 583) (SEQ ID 584) CH19_1-E6xl2C6 (SEQ ID 596) (SEQ ID 597) CH19_2G6_302xl2C6 (SEQ ID 609) (SEQ ID 610) CDH19 × CD3 CH19_2G6_302_VKGxl2C6 (SEQ ID 13) CH19_0-E11xl2C6 (SEQ ID 26) CH19_5-G4xl2C6 (SEQ ID 39) CH19_8-H6xl2C6 (SEQ ID 52) CH19_2-C11xl2C6 (SEQ ID 65) CH19_2-A10xl2C6 (SEQ ID 78) CH19_1-D11xl2C6 (SEQ ID 91) CH19_9-F9xl2C6 (SEQ ID 104) CH19_1-H8xl2C6 (SEQ ID 117) CH19_1-B12xl2C6 (SEQ ID 130) CH19_0-C4xl2C6 (SEQ ID 143) CH19_3-F2xl2C6 (SEQ ID 156) CH19_3-B10xl2C6 (SEQ ID 169) CH19_0-G4xl2C6 (SEQ ID 182) CH19_0-H5xl2C6 (SEQ ID 195) CH19_0-B8xl2C6 (SEQ ID 208) CH19_2-D9xl2C6 (SEQ ID 221) CH19_8-H7xl2C6 (SEQ ID 234) CH19_9-C2xl2C6 (SEQ ID 247) CH19_3-D5xl2C6 (SEQ ID 260) CH19_1-G11xl2C6 (SEQ ID 273) CH19_1-H11xl2C6 (SEQ ID 286) CH19_9-F3xl2C6 (SEQ ID 299) CH19_2-G6xl2C6 (SEQ ID 312) CH19_2-H7xl2C6 (SEQ ID 325) CH19_5-B3xl2C6 (SEQ ID 338) CH19_5-E10xl2C6 (SEQ ID 351) CH19_6-G10xl2C6 (SEQ ID 364) CH19_4-H8xl2C6 (SEQ ID 377) CH19_2-E4xl2C6 (SEQ ID 390) CH19_6-B8xl2C6 (SEQ ID 403) CH19_0-B4xl2C6 (SEQ ID 416) CH19_9-F1xl2C6 (SEQ ID 429) CH19_4-A7xl2C6 (SEQ ID 442) CH19_6-E12xl2C6 (SEQ ID 455) CH19_6-C12xl2C6 (SEQ ID 468) CH19_6-A7xl2C6 (SEQ ID 481) CH19_6-G8xl2C6 (SEQ ID 494) CH19_6-F9xl2C6 (SEQ ID 507) CH19_0-C11xl2C6 (SEQ ID 520) CH19_8-F6xl2C6 (SEQ ID 533) CH19_0-G9xl2C6 (SEQ ID 546) CH19_1-E11xl2C6 (SEQ ID 559) CH19_0-F5xl2C6 (SEQ ID 572) CH19_1-E1xl2C6 (SEQ ID 585) CH19_1-E6xl2C6 (SEQ ID 598) CH19_2G6_302xl2C6 (SEQ ID 611) SEQ ID Designation 1. CH19_2G6_302_VKGxl2C6-156 2. CH19_0-E11xl2C6-156 3. CH19_5-G4xl2C6-156 4. CH19_8-H6xl2C6-156 5. CH19_2-C11xl2C6-156 6. CH19_2-A10xl2C6-156 7. CH19_1-D11xl2C6-156 8. CH19_9-F9xl2C6-156 9. CH19_1-H8xl2C6-156 10. CH19_1-B12xl2C6-156 11. CH19_0-C4xl2C6-156 12. CH19_3-F2xl2C6-156 13. CH19_3-B10xl2C6-156 14. CH19_0-G4xl2C6-156 15. CH19_0-H5xl2C6-156 16. CH19_0-B8xl2C6-156 17. CH19_2-D9xl2C6-156 18. CH19_8-H7xl2C6-156 19. CH19_9-C2xl2C6-156 20. CH19_3-D5xl2C6-156 21. CH19_1-G11xl2C6-156 22. CH19_1-H11xl2C6-156 23. CH19_9-F3xl2C6-156 24. CH19_2-G6xl2C6-156 25. CH19_2-H7xl2C6-156 26. CH19_5-B3xl2C6-156 27. CH19_5-E10xl2C6-156 28. CH19_6-G10xl2C6-156 29. CH19_4-H8xl2C6-156 30. CH19_2-E4xl2C6-156 31. CH19_6-B8xl2C6-156 32. CH19_0-B4xl2C6-156 33. CH19_9-F1xl2C6-156 34. CH19_4-A7xl2C6-156 35. CH19_6-E12xl2C6-156 36. CH19_6-C12xl2C6-156 37. CH19_6-A7xl2C6-156 38. CH19_6-G8xl2C6-156 39. CH19_6-F9xl2C6-156 40. CH19_0-C11xl2C6-156 41. CH19_8-F6xl2C6-156 42. CH19_0-G9xl2C6-156 43. CH19_1-E11xl2C6-156 44. CH19_0-F5xl2C6-156 45. CH19_1-E1xl2C6-156 46. CH19_1-E6xl2C6-156 47. CH19_2G6_302xl2C6-156 48. CH19_2G6_302_VKGxl2C6-LFcBY 49. CH19_0-E11xl2C6-LFcBY 50. CH19_5-G4xl2C6-LFcBY 51. CH19_8-H6xl2C6-LFcBY 52. CH19_2-C11xl2C6-LFcBY 53. CH19_2-A10xl2C6-LFcBY 54. CH19_1-D11xl2C6-LFcBY 55. CH19_9-F9xl2C6-LFcBY 56. CH19_1-H8xl2C6-LFcBY 57. CH19_1-B12xl2C6-LFcBY 58. CH19_0-C4xl2C6-LFcBY 59. CH19_3-F2xl2C6-LFcBY 60. CH19_3-B10xl2C6-LFcBY 61. CH19_0-G4xl2C6-LFcBY 62. CH19_0-H5xl2C6-LFcBY 63. CH19_0-B8xl2C6-LFcBY 64. CH19_2-D9xl2C6-LFcBY 65. CH19_8-H7xl2C6-LFcBY 66. CH19_9-C2xl2C6-LFcBY 67. CH19_3-D5xl2C6-LFcBY 68. CH19_1-G11xl2C6-LFcBY 69. CH19_1-H11xl2C6-LFcBY 70. CH19_9-F3xl2C6-LFcBY 71. CH19_2-G6xl2C6-LFcBY 72. CH19_2-H7xl2C6-LFcBY 73. CH19_5-B3xl2C6-LFcBY 74. CH19_5-E10xl2C6-LFcBY 75. CH19_6-G10xl2C6-LFcBY 76. CH19_4-H8xl2C6-LFcBY 77. CH19_2-E4xl2C6-LFcBY 78. CH19_6-B8xl2C6-LFcBY 79. CH19_0-B4xl2C6-LFcBY 80. CH19_9-F1xl2C6-LFcBY 81. CH19_4-A7xl2C6-LFcBY 82. CH19_6-E12xl2C6-LFcBY 83. CH19_6-C12xl2C6-LFcBY 84. CH19_6-A7xl2C6-LFcBY 85. CH19_6-G8xl2C6-LFcBY 86. CH19_6-F9xl2C6-LFcBY 87. CH19_0-C11xl2C6-LFcBY 88. CH19_8-F6xl2C6-LFcBY 89. CH19_0-G9xl2C6-LFcBY 90. CH19_1-E11xl2C6-LFcBY 91. CH19_0-F5xl2C6-LFcBY 92. CH19_1-E1xl2C6-LFcBY 93. CH19_1-E6xl2C6-LFcBY 94. CH19_2G6_302xl2C6-LFcBY 95. CH19_2G6_302_VKGxl2C6-LFcBY-156 96. CH19_0-E11xl2C6-LFcBY-156 97. CH19_5-G4xl2C6-LFcBY-156 98. CH19_8-H6xl2C6-LFcBY-156 99. CH19_2-C11xl2C6-LFcBY-156 100. CH19_2-A10xl2C6-LFcBY-156 101. CH19_1-D11xl2C6-LFcBY-156 102. CH19_9-F9xl2C6-LFcBY-156 103. CH19_1-H8xl2C6-LFcBY-156 104. CH19_1-B12xl2C6-LFcBY-156 105. CH19_0-C4xl2C6-LFcBY-156 106. CH19_3-F2xl2C6-LFcBY-156 107. CH19_3-B10xl2C6-LFcBY-156 108. CH19_0-G4xl2C6-LFcBY-156 109. CH19_0-H5xl2C6-LFcBY-156 110. CH19_0-B8xl2C6-LFcBY-156 111. CH19_2-D9xl2C6-LFcBY-156 112. CH19_8-H7xl2C6-LFcBY-156 113. CH19_9-C2xl2C6-LFcBY-156 114. CH19_3-D5xl2C6-LFcBY-156 115. CH19_1-G11xl2C6-LFcBY-156 116. CH19_1-H11xl2C6-LFcBY-156 117. CH19_9-F3xl2C6-LFcBY-156 118. CH19_2-G6xl2C6-LFcBY-156 119. CH19_2-H7xl2C6-LFcBY-156 120. CH19_5-B3xl2C6-LFcBY-156 121. CH19_5-E10xl2C6-LFcBY-156 122. CH19_6-G10xl2C6-LFcBY-156 123. CH19_4-H8xl2C6-LFcBY-156 124. CH19_2-E4xl2C6-LFcBY-156 125. CH19_6-B8xl2C6-LFcBY-156 126. CH19_0-B4xl2C6-LFcBY-156 127. CH19_9-F1xl2C6-LFcBY-156 128. CH19_4-A7xl2C6-LFcBY-156 129. CH19_6-E12xl2C6-LFcBY-156 130. CH19_6-C12xl2C6-LFcBY-156 131. CH19_6-A7xl2C6-LFcBY-156 132. CH19_6-G8xl2C6-LFcBY-156 133. CH19_6-F9xl2C6-LFcBY-156 134. CH19_0-C11xl2C6-LFcBY-156 135. CH19_8-F6xl2C6-LFcBY-156 136. CH19_0-G9xl2C6-LFcBY-156 137. CH19_1-E11xl2C6-LFcBY-156 138. CH19_0-F5xl2C6-LFcBY-156 139. CH19_1-E1xl2C6-LFcBY-156 140. CH19_1-E6xl2C6-LFcBY-156 141. CH19_2G6_302xl2C6-LFcBY-156 142. CH19_2G6_302_VKGxl2C6-Cys-Loop 143. CH19_0-E11xl2C6-Cys-Loop 144. CH19_5-G4xl2C6-Cys-Loop 145. CH19_8-H6xl2C6-Cys-Loop 146. CH19_2-C11xl2C6-Cys-Loop 147. CH19_2-A10xl2C6-Cys-Loop 148. CH19_1-D11xl2C6-Cys-Loop 149. CH19_9-F9xl2C6-Cys-Loop 150. CH19_1-H8xl2C6-Cys-Loop 151. CH19_1-B12xl2C6-Cys-Loop 152. CH19_0-C4xl2C6-Cys-Loop 153. CH19_3-F2xl2C6-Cys-Loop 154. CH19_3-B10xl2C6-Cys-Loop 155. CH19_0-G4xl2C6-Cys-Loop 156. CH19_0-H5xl2C6-Cys-Loop 157. CH19_0-B8xl2C6-Cys-Loop 158. CH19_2-D9xl2C6-Cys-Loop 159. CH19_8-H7xl2C6-Cys-Loop 160. CH19_9-C2xl2C6-Cys-Loop 161. CH19_3-D5xl2C6-Cys-Loop 162. CH19_1-G11xl2C6-Cys-Loop 163. CH19_1-H11xl2C6-Cys-Loop 164. CH19_9-F3xl2C6-Cys-Loop 165. CH19_2-G6xl2C6-Cys-Loop 166. CH19_2-H7xl2C6-Cys-Loop 167. CH19_5-B3xl2C6-Cys-Loop 168. CH19_5-E10xl2C6-Cys-Loop 169. CH19_6-G10xl2C6-Cys-Loop 170. CH19_4-H8xl2C6-Cys-Loop 171. CH19_2-E4xl2C6-Cys-Loop 172. CH19_6-B8xl2C6-Cys-Loop 173. CH19_0-B4xl2C6-Cys-Loop 174. CH19_9-F1xl2C6-Cys-Loop 175. CH19_4-A7xl2C6-Cys-Loop 176. CH19_6-E12xl2C6-Cys-Loop 177. CH19_6-C12xl2C6-Cys-Loop 178. CH19_6-A7xl2C6-Cys-Loop 179. CH19_6-G8xl2C6-Cys-Loop 180. CH19_6-F9xl2C6-Cys-Loop 181. CH19_0-C11xl2C6-Cys-Loop 182. CH19_8-F6xl2C6-Cys-Loop 183. CH19_0-G9xl2C6-Cys-Loop 184. CH19_1-E11xl2C6-Cys-Loop 185. CH19_0-F5xl2C6-Cys-Loop 186. CH19_1-E1xl2C6-Cys-Loop 187. CH19_1-E6xl2C6-Cys-Loop 188. CH19_2G6_302xl2C6-Cys-Loop 189. CH19_2G6_302_VKGxl2C6-LH-FcB-CH 190. CH19_0-E11xl2C6-LH-FcB-CH 191. CH19_5-G4xl2C6-LH-FcB-CH 192. CH19_8-H6xl2C6-LH-FcB-CH 193. CH19_2-C11xl2C6-LH-FcB-CH 194. CH19_2-A10xl2C6-LH-FcB-CH 195. CH19_1-D11xl2C6-LH-FcB-CH 196. CH19_9-F9xl2C6-LH-FcB-CH 197. CH19_1-H8xl2C6-LH-FcB-CH 198. CH19_1-B12xl2C6-LH-FcB-CH 199. CH19_0-C4xl2C6-LH-FcB-CH 200. CH19_3-F2xl2C6-LH-FcB-CH 201. CH19_3-B10xl2C6-LH-FcB-CH 202. CH19_0-G4xl2C6-LH-FcB-CH 203. CH19_0-H5xl2C6-LH-FcB-CH 204. CH19_0-B8xl2C6-LH-FcB-CH 205. CH19_2-D9xl2C6-LH-FcB-CH 206. CH19_8-H7xl2C6-LH-FcB-CH 207. CH19_9-C2xl2C6-LH-FcB-CH 208. CH19_3-D5xl2C6-LH-FcB-CH 209. CH19_1-G11xl2C6-LH-FcB-CH 210. CH19_1-H11xl2C6-LH-FcB-CH 211. CH19_9-F3xl2C6-LH-FcB-CH 212. CH19_2-G6xl2C6-LH-FcB-CH 213. CH19_2-H7xl2C6-LH-FcB-CH 214. CH19_5-B3xl2C6-LH-FcB-CH 215. CH19_5-E10xl2C6-LH-FcB-CH 216. CH19_6-G10xl2C6-LH-FcB-CH 217. CH19_4-H8xl2C6-LH-FcB-CH 218. CH19_2-E4xl2C6-LH-FcB-CH 219. CH19_6-B8xl2C6-LH-FcB-CH 220. CH19_0-B4xl2C6-LH-FcB-CH 221. CH19_9-F1xl2C6-LH-FcB-CH 222. CH19_4-A7xl2C6-LH-FcB-CH 223. CH19_6-E12xl2C6-LH-FcB-CH 224. CH19_6-C12xl2C6-LH-FcB-CH 225. CH19_6-A7xl2C6-LH-FcB-CH 226. CH19_6-G8xl2C6-LH-FcB-CH 227. CH19_6-F9xl2C6-LH-FcB-CH 228. CH19_0-C11xl2C6-LH-FcB-CH 229. CH19_8-F6xl2C6-LH-FcB-CH 230. CH19_0-G9xl2C6-LH-FcB-CH 231. CH19_1-E11xl2C6-LH-FcB-CH 232. CH19_0-F5xl2C6-LH-FcB-CH 233. CH19_1-E1xl2C6-LH-FcB-CH 234. CH19_1-E6xl2C6-LH-FcB-CH 235. CH19_2G6_302xl2C6-LH-FcB-CH 236. CH19_2G6_302_VKGxl2C6-LH-FcB-LH 237. CH19_0-E11xl2C6-LH-FcB-LH 238. CH19_5-G4xl2C6-LH-FcB-LH 239. CH19_8-H6xl2C6-LH-FcB-LH 240. CH19_2-C11xl2C6-LH-FcB-LH 241. CH19_2-A10xl2C6-LH-FcB-LH 242. CH19_1-D11xl2C6-LH-FcB-LH 243. CH19_9-F9xl2C6-LH-FcB-LH 244. CH19_1-H8xl2C6-LH-FcB-LH 245. CH19_1-B12xl2C6-LH-FcB-LH 246. CH19_0-C4xl2C6-LH-FcB-LH 247. CH19_3-F2xl2C6-LH-FcB-LH 248. CH19_3-B10xl2C6-LH-FcB-LH 249. CH19_0-G4xl2C6-LH-FcB-LH 250. CH19_0-H5xl2C6-LH-FcB-LH 251. CH19_0-B8xl2C6-LH-FcB-LH 252. CH19_2-D9xl2C6-LH-FcB-LH 253. CH19_8-H7xl2C6-LH-FcB-LH 254. CH19_9-C2xl2C6-LH-FcB-LH 255. CH19_3-D5xl2C6-LH-FcB-LH 256. CH19_1-G11xl2C6-LH-FcB-LH 257. CH19_1-H11xl2C6-LH-FcB-LH 258. CH19_9-F3xl2C6-LH-FcB-LH 259. CH19_2-G6xl2C6-LH-FcB-LH 260. CH19_2-H7xl2C6-LH-FcB-LH 261. CH19_5-B3xl2C6-LH-FcB-LH 262. CH19_5-E10xl2C6-LH-FcB-LH 263. CH19_6-G10xl2C6-LH-FcB-LH 264. CH19_4-H8xl2C6-LH-FcB-LH 265. CH19_2-E4xl2C6-LH-FcB-LH 266. CH19_6-B8xl2C6-LH-FcB-LH 267. CH19_0-B4xl2C6-LH-FcB-LH 268. CH19_9-F1xl2C6-LH-FcB-LH 269. CH19_4-A7xl2C6-LH-FcB-LH 270. CH19_6-E12xl2C6-LH-FcB-LH 271. CH19_6-C12xl2C6-LH-FcB-LH 272. CH19_6-A7xl2C6-LH-FcB-LH 273. CH19_6-G8xl2C6-LH-FcB-LH 274. CH19_6-F9xl2C6-LH-FcB-LH 275. CH19_0-C11xl2C6-LH-FcB-LH 276. CH19_8-F6xl2C6-LH-FcB-LH 277. CH19_0-G9xl2C6-LH-FcB-LH 278. CH19_1-E11xl2C6-LH-FcB-LH 279. CH19_0-F5xl2C6-LH-FcB-LH 280. CH19_1-E1xl2C6-LH-FcB-LH 281. CH19_1-E6xl2C6-LH-FcB-LH 282. CH19_2G6_302xl2C6-LH-FcB-LH 283. CH19_2G6_302_VKGxl2C6-LY-FcB-LH 284. CH19_0-E11xl2C6-LY-FcB-LH 285. CH19_5-G4xl2C6-LY-FcB-LH 286. CH19_8-H6xl2C6-LY-FcB-LH 287. CH19_2-C11xl2C6-LY-FcB-LH 288. CH19_2-A10xl2C6-LY-FcB-LH 289. CH19_1-D11xl2C6-LY-FcB-LH 290. CH19_9-F9xl2C6-LY-FcB-LH 291. CH19_1-H8xl2C6-LY-FcB-LH 292. CH19_1-B12xl2C6-LY-FcB-LH 293. CH19_0-C4xl2C6-LY-FcB-LH 294. CH19_3-F2xl2C6-LY-FcB-LH 295. CH19_3-B10xl2C6-LY-FcB-LH 296. CH19_0-G4xl2C6-LY-FcB-LH 297. CH19_0-H5xl2C6-LY-FcB-LH 298. CH19_0-B8xl2C6-LY-FcB-LH 299. CH19_2-D9xl2C6-LY-FcB-LH 300. CH19_8-H7xl2C6-LY-FcB-LH 301. CH19_9-C2xl2C6-LY-FcB-LH 302. CH19_3-D5xl2C6-LY-FcB-LH 303. CH19_1-G11xl2C6-LY-FcB-LH 304. CH19_1-H11xl2C6-LY-FcB-LH 305. CH19_9-F3xl2C6-LY-FcB-LH 306. CH19_2-G6xl2C6-LY-FcB-LH 307. CH19_2-H7xl2C6-LY-FcB-LH 308. CH19_5-B3xl2C6-LY-FcB-LH 309. CH19_5-E10xl2C6-LY-FcB-LH 310. CH19_6-G10xl2C6-LY-FcB-LH 311. CH19_4-H8xl2C6-LY-FcB-LH 312. CH19_2-E4xl2C6-LY-FcB-LH 313. CH19_6-B8xl2C6-LY-FcB-LH 314. CH19_0-B4xl2C6-LY-FcB-LH 315. CH19_9-F1xl2C6-LY-FcB-LH 316. CH19_4-A7xl2C6-LY-FcB-LH 317. CH19_6-E12xl2C6-LY-FcB-LH 318. CH19_6-C12xl2C6-LY-FcB-LH 319. CH19_6-A7xl2C6-LY-FcB-LH 320. CH19_6-G8xl2C6-LY-FcB-LH 321. CH19_6-F9xl2C6-LY-FcB-LH 322. CH19_0-C11xl2C6-LY-FcB-LH 323. CH19_8-F6xl2C6-LY-FcB-LH 324. CH19_0-G9xl2C6-LY-FcB-LH 325. CH19_1-E11xl2C6-LY-FcB-LH 326. CH19_0-F5xl2C6-LY-FcB-LH 327. CH19_1-E1xl2C6-LY-FcB-LH 328. CH19_1-E6xl2C6-LY-FcB-LH 329. CH19_2G6_302xl2C6-LY-FcB-LH 330. CH19_2G6_302_VKGxl2C6-LH-FcB-CH-156 331. CH19_0-E11xl2C6-LH-FcB-CH-156 332. CH19_5-G4xl2C6-LH-FcB-CH-156 333. CH19_8-H6xl2C6-LH-FcB-CH-156 334. CH19_2-C11xl2C6-LH-FcB-CH-156 335. CH19_2-A10xl2C6-LH-FcB-CH-156 336. CH19_1-D11xl2C6-LH-FcB-CH-156 337. CH19_9-F9xl2C6-LH-FcB-CH-156 338. CH19_1-H8xl2C6-LH-FcB-CH-156 339. CH19_1-B12xl2C6-LH-FcB-CH-156 340. CH19_0-C4xl2C6-LH-FcB-CH-156 341. CH19_3-F2xl2C6-LH-FcB-CH-156 342. CH19_3-B10xl2C6-LH-FcB-CH-156 343. CH19_0-G4xl2C6-LH-FcB-CH-156 344. CH19_0-H5xl2C6-LH-FcB-CH-156 345. CH19_0-B8xl2C6-LH-FcB-CH-156 346. CH19_2-D9xl2C6-LH-FcB-CH-156 347. CH19_8-H7xl2C6-LH-FcB-CH-156 348. CH19_9-C2xl2C6-LH-FcB-CH-156 349. CH19_3-D5xl2C6-LH-FcB-CH-156 350. CH19_1-G11xl2C6-LH-FcB-CH-156 351. CH19_1-H11xl2C6-LH-FcB-CH-156 352. CH19_9-F3xl2C6-LH-FcB-CH-156 353. CH19_2-G6xl2C6-LH-FcB-CH-156 354. CH19_2-H7xl2C6-LH-FcB-CH-156 355. CH19_5-B3xl2C6-LH-FcB-CH-156 356. CH19_5-E10xl2C6-LH-FcB-CH-156 357 CH19_6-G10xl2C6-LH-FcB-CH-156 358. CH19_4-H8xl2C6-LH-FcB-CH-156 359. CH19_2-E4xl2C6-LH-FcB-CH-156 360. CH19_6-B8xl2C6-LH-FcB-CH-156 361. CH19_0-B4xl2C6-LH-FcB-CH-156 362. CH19_9-F1xl2C6-LH-FcB-CH-156 363. CH19_4-A7xl2C6-LH-FcB-CH-156 364. CH19_6-E12xl2C6-LH-FcB-CH-156 365. CH19_6-C12xl2C6-LH-FcB-CH-156 366. CH19_6-A7xl2C6-LH-FcB-CH-156 367. CH19_6-G8xl2C6-LH-FcB-CH-156 368. CH19_6-F9xl2C6-LH-FcB-CH-156 369. CH19_0-C11xl2C6-LH-FcB-CH-156 370. CH19_8-F6xl2C6-LH-FcB-CH-156 371. CH19_0-G9xl2C6-LH-FcB-CH-156 372. CH19_1-E11xl2C6-LH-FcB-CH-156 373. CH19_0-F5xl2C6-LH-FcB-CH-156 374. CH19_1-E1xl2C6-LH-FcB-CH-156 375. CH19_1-E6xl2C6-LH-FcB-CH-156 376. CH19_2G6_302xl2C6-LH-FcB-CH-156 377. CH19_2G6_302_VKGxl2C6-LH-FcB-LH-156 378. CH19_0-E11xl2C6-LH-FcB-LH-156 379. CH19_5-G4xl2C6-LH-FcB-LH-156 380. CH19_8-H6xl2C6-LH-FcB-LH-156 381. CH19_2-C11xl2C6-LH-FcB-LH-156 382. CH19_2-A10xl2C6-LH-FcB-LH-156 383. CH19_1-D11xl2C6-LH-FcB-LH-156 384. CH19_9-F9xl2C6-LH-FcB-LH-156 385. CH19_1-H8xl2C6-LH-FcB-LH-156 386. CH19_1-B12xl2C6-LH-FcB-LH-156 387. CH19_0-C4xl2C6-LH-FcB-LH-156 388. CH19_3-F2xl2C6-LH-FcB-LH-156 389. CH19_3-B10xl2C6-LH-FcB-LH-156 390. CH19_0-G4xl2C6-LH-FcB-LH-156 391. CH19_0-H5xl2C6-LH-FcB-LH-156 392. CH19_0-B8xl2C6-LH-FcB-LH-156 393. CH19_2-D9xl2C6-LH-FcB-LH-156 394. CH19_8-H7xl2C6-LH-FcB-LH-156 395. CH19_9-C2xl2C6-LH-FcB-LH-156 396. CH19_3-D5xl2C6-LH-FcB-LH-156 397. CH19_1-G11xl2C6-LH-FcB-LH-156 398. CH19_1-H11xl2C6-LH-FcB-LH-156 399. CH19_9-F3xl2C6-LH-FcB-LH-156 400. CH19_2-G6xl2C6-LH-FcB-LH-156 401. CH19_2-H7xl2C6-LH-FcB-LH-156 402. CH19_5-B3xl2C6-LH-FcB-LH-156 403. CH19_5-E10xl2C6-LH-FcB-LH-156 404. CH19_6-G10xl2C6-LH-FcB-LH-156 405. CH19_4-H8xl2C6-LH-FcB-LH-156 406. CH19_2-E4xl2C6-LH-FcB-LH-156 407. CH19_6-B8xl2C6-LH-FcB-LH-156 408. CH19_0-B4xl2C6-LH-FcB-LH-156 409. CH19_9-F1xl2C6-LH-FcB-LH-156 410. CH19_4-A7xl2C6-LH-FcB-LH-156 411. CH19_6-E12xl2C6-LH-FcB-LH-156 412. CH19_6-C12xl2C6-LH-FcB-LH-156 413. CH19_6-A7xl2C6-LH-FcB-LH-156 414. CH19_6-G8xl2C6-LH-FcB-LH-156 415. CH19_6-F9xl2C6-LH-FcB-LH-156 416. CH19_0-C11xl2C6-LH-FcB-LH-156 417. CH19_8-F6xl2C6-LH-FcB-LH-156 418. CH19_0-G9xl2C6-LH-FcB-LH-156 419. CH19_1-E11xl2C6-LH-FcB-LH-156 420. CH19_0-F5xl2C6-LH-FcB-LH-156 421. CH19_1-E1xl2C6-LH-FcB-LH-156 422. CH19_1-E6xl2C6-LH-FcB-LH-156 423. CH19_2G6_302xl2C6-LH-FcB-LH-156 424. CH19_2G6_302_VKGxl2C6-LY-FcB-LH-156 425. CH19_0-E11xl2C6-LY-FcB-LH-156 426. CH19_5-G4xl2C6-LY-FcB-LH-156 427. CH19_8-H6xl2C6-LY-FcB-LH-156 428. CH19_2-C11xl2C6-LY-FcB-LH-156 429. CH19_2-A10xl2C6-LY-FcB-LH-156 430. CH19_1-D11xl2C6-LY-FcB-LH-156 431. CH19_9-F9xl2C6-LY-FcB-LH-156 432. CH19_1-H8xl2C6-LY-FcB-LH-156 433. CH19_1-B12xl2C6-LY-FcB-LH-156 434. CH19_0-C4xl2C6-LY-FcB-LH-156 435. CH19_3-F2xl2C6-LY-FcB-LH-156 436. CH19_3-B10xl2C6-LY-FcB-LH-156 437. CH19_0-G4xl2C6-LY-FcB-LH-156 438. CH19_0-H5xl2C6-LY-FcB-LH-156 439. CH19_0-B8xl2C6-LY-FcB-LH-156 440. CH19_2-D9xl2C6-LY-FcB-LH-156 441. CH19_8-H7xl2C6-LY-FcB-LH-156 442. CH19_9-C2xl2C6-LY-FcB-LH-156 443. CH19_3-D5xl2C6-LY-FcB-LH-156 444. CH19_1-G11xl2C6-LY-FcB-LH-156 445. CH19_1-H11xl2C6-LY-FcB-LH-156 446. CH19_9-F3xl2C6-LY-FcB-LH-156 447. CH19_2-G6xl2C6-LY-FcB-LH-156 448. CH19_2-H7xl2C6-LY-FcB-LH-156 449. CH19_5-B3xl2C6-LY-FcB-LH-156 450. CH19_5-E10xl2C6-LY-FcB-LH-156 451. CH19_6-G10xl2C6-LY-FcB-LH-156 452. CH19_4-H8xl2C6-LY-FcB-LH-156 453. CH19_2-E4xl2C6-LY-FcB-LH-156 454. CH19_6-B8xl2C6-LY-FcB-LH-156 455. CH19_0-B4xl2C6-LY-FcB-LH-156 456. CH19_9-F1xl2C6-LY-FcB-LH-156 457. CH19_4-A7xl2C6-LY-FcB-LH-156 458. CH19_6-E12xl2C6-LY-FcB-LH-156 459. CH19_6-C12xl2C6-LY-FcB-LH-156 460. CH19_6-A7xl2C6-LY-FcB-LH-156 461. CH19_6-G8xl2C6-LY-FcB-LH-156 462. CH19_6-F9xl2C6-LY-FcB-LH-156 463. CH19_0-C11xl2C6-LY-FcB-LH-156 464. CH19_8-F6xl2C6-LY-FcB-LH-156 465. CH19_0-G9xl2C6-LY-FcB-LH-156 466. CH19_1-E11xl2C6-LY-FcB-LH-156 467. CH19_0-F5xl2C6-LY-FcB-LH-156 468. CH19_1-E1xl2C6-LY-FcB-LH-156 469. CH19_1-E6xl2C6-LY-FcB-LH-156 470. CH19_2G6_302xl2C6-LY-FcB-LH-156 471. CH19_2G6_302_VKGxl2C6-ALB8 472. CH19_0-E11xl2C6-ALB8 473. CH19_5-G4xl2C6-ALB8 474. CH19_8-H6xl2C6-ALB8 475. CH19_2-C11xl2C6-ALB8 476. CH19_2-A10xl2C6-ALB8 477. CH19_1-D11xl2C6-ALB8 478. CH19_9-F9xl2C6-ALB8 479. CH19_1-H8xl2C6-ALB8 480. CH19_1-B12xl2C6-ALB8 481. CH19_0-C4xl2C6-ALB8 482. CH19_3-F2xl2C6-ALB8 483. CH19_3-B10xl2C6-ALB8 484. CH19_0-G4xl2C6-ALB8 485. CH19_0-H5xl2C6-ALB8 486. CH19_0-B8xl2C6-ALB8 487. CH19_2-D9xl2C6-ALB8 488. CH19_8-H7xl2C6-ALB8 489. CH19_9-C2xl2C6-ALB8 490. CH19_3-D5xl2C6-ALB8 491. CH19_1-G11xl2C6-ALB8 492. CH19_1-H11xl2C6-ALB8 493. CH19_9-F3xl2C6-ALB8 494. CH19_2-G6xl2C6-ALB8 495. CH19_2-H7xl2C6-ALB8 496. CH19_5-B3xl2C6-ALB8 497. CH19_5-E10xl2C6-ALB8 498. CH19_6-G10xl2C6-ALB8 499. CH19_4-H8xl2C6-ALB8 500. CH19_2-E4xl2C6-ALB8 501. CH19_6-B8xl2C6-ALB8 502. CH19_0-B4xl2C6-ALB8 503. CH19_9-F1xl2C6-ALB8 504. CH19_4-A7xl2C6-ALB8 505. CH19_6-E12xl2C6-ALB8 506. CH19_6-C12xl2C6-ALB8 507. CH19_6-A7xl2C6-ALB8 508. CH19_6-G8xl2C6-ALB8 509. CH19_6-F9xl2C6-ALB8 510. CH19_0-C11xl2C6-ALB8 511. CH19_8-F6xl2C6-ALB8 512. CH19_0-G9xl2C6-ALB8 513. CH19_1-E11xl2C6-ALB8 514. CH19_0-F5xl2C6-ALB8 515. CH19_1-E1xl2C6-ALB8 516. CH19_1-E6xl2C6-ALB8 517. CH19_2G6_302xl2C6-ALB8 518. CH19_2G6_302_VKGxl2C6-ALB23 519. CH19_0-E11xl2C6-ALB23 520. CH19_5-G4xl2C6-ALB23 521. CH19_8-H6xl2C6-ALB23 522. CH19_2-C11xl2C6-ALB23 523. CH19_2-A10xl2C6-ALB23 524. CH19_1-D11xl2C6-ALB23 525. CH19_9-F9xl2C6-ALB23 526. CH19_1-H8xl2C6-ALB23 527. CH19_1-B12xl2C6-ALB23 528. CH19_0-C4xl2C6-ALB23 529. CH19_3-F2xl2C6-ALB23 530. CH19_3-B10xl2C6-ALB23 531. CH19_0-G4xl2C6-ALB23 532. CH19_0-H5xl2C6-ALB23 533. CH19_0-B8xl2C6-ALB23 534. CH19_2-D9xl2C6-ALB23 535. CH19_8-H7xl2C6-ALB23 536. CH19_9-C2xl2C6-ALB23 537. CH19_3-D5xl2C6-ALB23 538. CH19_1-G11xl2C6-ALB23 539. CH19_1-H11xl2C6-ALB23 540. CH19_9-F3xl2C6-ALB23 541. CH19_2-G6xl2C6-ALB23 542. CH19_2-H7xl2C6-ALB23 543. CH19_5-B3xl2C6-ALB23 544. CH19_5-E10xl2C6-ALB23 545. CH19_6-G10xl2C6-ALB23 546. CH19_4-H8xl2C6-ALB23 547. CH19_2-E4xl2C6-ALB23 548. CH19_6-B8xl2C6-ALB23 549. CH19_0-B4xl2C6-ALB23 550. CH19_9-F1xl2C6-ALB23 551. CH19_4-A7xl2C6-ALB23 552. CH19_6-E12xl2C6-ALB23 553. CH19_6-C12xl2C6-ALB23 554. CH19_6-A7xl2C6-ALB23 555. CH19_6-G8xl2C6-ALB23 556. CH19_6-F9xl2C6-ALB23 557. CH19_0-C11xl2C6-ALB23 558. CH19_8-F6xl2C6-ALB23 559. CH19_0-G9xl2C6-ALB23 560. CH19_1-E11xl2C6-ALB23 561. CH19_0-F5xl2C6-ALB23 562. CH19_1-E1xl2C6-ALB23 563. CH19_1-E6xl2C6-ALB23 564. CH19_2G6_302xl2C6-ALB23 565. CH19_2G6_302_VKGxl2C6-HALBwD 566. CH19_0-E11xl2C6-HALBwD 567. CH19_5-G4xl2C6-HALBwD 568. CH19_8-H6xl2C6-HALBwD 569. CH19_2-C11xl2C6-HALBwD 570. CH19_2-A10xl2C6-HALBwD 571. CH19_1-D11xl2C6-HALBwD 572. CH19_9-F9xl2C6-HALBwD 573. CH19_1-H8xl2C6-HALBwD 574. CH19_1-B12xl2C6-HALBwD 575. CH19_0-C4xl2C6-HALBwD 576. CH19_3-F2xl2C6-HALBwD 577. CH19_3-B10xl2C6-HALBwD 578. CH19_0-G4xl2C6-HALBwD 579. CH19_0-H5xl2C6-HALBwD 580. CH19_0-B8xl2C6-HALBwD 581. CH19_2-D9xl2C6-HALBwD 582. CH19_8-H7xl2C6-HALBwD 583. CH19_9-C2xl2C6-HALBwD 584. CH19_3-D5xl2C6-HALBwD 585. CH19_1-G11xl2C6-HALBwD 586. CH19_1-H11xl2C6-HALBwD 587. CH19_9-F3xl2C6-HALBwD 588. CH19_2-G6xl2C6-HALBwD 589. CH19_2-H7xl2C6-HALBwD 590. CH19_5-B3xl2C6-HALBwD 591. CH19_5-E10xl2C6-HALBwD 592. CH19_6-G10xl2C6-HALBwD 593. CH19_4-H8xl2C6-HALBwD 594. CH19_2-E4xl2C6-HALBwD 595. CH19_6-B8xl2C6-HALBwD 596. CH19_0-B4xl2C6-HALBwD 597. CH19_9-F1xl2C6-HALBwD 598. CH19_4-A7xl2C6-HALBwD 599. CH19_6-E12xl2C6-HALBwD 600. CH19_6-C12xl2C6-HALBwD 601. CH19_6-A7xl2C6-HALBwD 602. CH19_6-G8xl2C6-HALBwD 603. CH19_6-F9xl2C6-HALBwD 604. CH19_0-C11xl2C6-HALBwD 605. CH19_8-F6xl2C6-HALBwD 606. CH19_0-G9xl2C6-HALBwD 607. CH19_1-E11xl2C6-HALBwD 608. CH19_0-F5xl2C6-HALBwD 609. CH19_1-E1xl2C6-HALBwD 610. CH19_1-E6xl2C6-HALBwD 611. CH19_2G6_302xl2C6-HALBwD 612. CH19_2G6_302_VKGxl2C6-HALB 613. CH19_0-E11xl2C6-HALB 614. CH19_5-G4xl2C6-HALB 615. CH19_8-H6xl2C6-HALB 616. CH19_2-C11xl2C6-HALB 617. CH19_2-A10xl2C6-HALB 618. CH19_1-D11xl2C6-HALB 619. CH19_9-F9xl2C6-HALB 620. CH19_1-H8xl2C6-HALB 621. CH19_1-B12xl2C6-HALB 622. CH19_0-C4xl2C6-HALB 623. CH19_3-F2xl2C6-HALB 624. CH19_3-B10xl2C6-HALB 625. CH19_0-G4xl2C6-HALB 626. CH19_0-H5xl2C6-HALB 627. CH19_0-B8xl2C6-HALB 628. CH19_2-D9xl2C6-HALB 629. CH19_8-H7xl2C6-HALB 630. CH19_9-C2xl2C6-HALB 631. CH19_3-D5xl2C6-HALB 632. CH19_1-G11xl2C6-HALB 633. CH19_1-H11xl2C6-HALB 634. CH19_9-F3xl2C6-HALB 635. CH19_2-G6xl2C6-HALB 636. CH19_2-H7xl2C6-HALB 637. CH19_5-B3xl2C6-HALB 638. CH19_5-E10xl2C6-HALB 639. CH19_6-G10xl2C6-HALB 640. CH19_4-H8xl2C6-HALB 641. CH19_2-E4xl2C6-HALB 642. CH19_6-B8xl2C6-HALB 643. CH19_0-B4xl2C6-HALB 644. CH19_9-F1xl2C6-HALB 645. CH19_4-A7xl2C6-HALB 646. CH19_6-E12xl2C6-HALB 647. CH19_6-C12xl2C6-HALB 648. CH19_6-A7xl2C6-HALB 649. CH19_6-G8xl2C6-HALB 650. CH19_6-F9xl2C6-HALB 651. CH19_0-C11xl2C6-HALB 652. CH19_8-F6xl2C6-HALB 653. CH19_0-G9xl2C6-HALB 654. CH19_1-E11xl2C6-HALB 655. CH19_0-F5xl2C6-HALB 656. CH19_1-E1xl2C6-HALB 657. CH19_1-E6xl2C6-HALB 658. CH19_2G6_302xl2C6-HALB 659. CH19_2G6_302_VKGxl2C6-HALB7 660. CH19_0-E11xl2C6-HALB7 661. CH19_5-G4xl2C6-HALB7 662. CH19_8-H6xl2C6-HALB7 663. CH19_2-C11xl2C6-HALB7 664. CH19_2-A10xl2C6-HALB7 665. CH19_1-D11xl2C6-HALB7 666. CH19_9-F9xl2C6-HALB7 667. CH19_1-H8xl2C6-HALB7 668. CH19_1-B12xl2C6-HALB7 669. CH19_0-C4xl2C6-HALB7 670. CH19_3-F2xl2C6-HALB7 671. CH19_3-B10xl2C6-HALB7 672. CH19_0-G4xl2C6-HALB7 673. CH19_0-H5xl2C6-HALB7 674. CH19_0-B8xl2C6-HALB7 675. CH19_2-D9xl2C6-HALB7 676. CH19_8-H7xl2C6-HALB7 677. CH19_9-C2xl2C6-HALB7 678. CH19_3-D5xl2C6-HALB7 679. CH19_1-G11xl2C6-HALB7 680. CH19_1-H11xl2C6-HALB7 681. CH19_9-F3xl2C6-HALB7 682. CH19_2-G6xl2C6-HALB7 683. CH19_2-H7xl2C6-HALB7 684. CH19_5-B3xl2C6-HALB7 685. CH19_5-E10xl2C6-HALB7 686. CH19_6-G10xl2C6-HALB7 687. CH19_4-H8xl2C6-HALB7 688. CH19_2-E4xl2C6-HALB7 689. CH19_6-B8xl2C6-HALB7 690. CH19_0-B4xl2C6-HALB7 691. CH19_9-F1xl2C6-HALB7 692. CH19_4-A7xl2C6-HALB7 693. CH19_6-E12xl2C6-HALB7 694. CH19_6-C12xl2C6-HALB7 695. CH19_6-A7xl2C6-HALB7 696. CH19_6-G8xl2C6-HALB7 697. CH19_6-F9xl2C6-HALB7 698. CH19_0-C11xl2C6-HALB7 699. CH19_8-F6xl2C6-HALB7 700. CH19_0-G9xl2C6-HALB7 701. CH19_1-E11xl2C6-HALB7 702. CH19_0-F5xl2C6-HALB7 703. CH19_1-E1xl2C6-HALB7 704. CH19_1-E6xl2C6-HALB7 705. CH19_2G6_302xl2C6-HALB7 706. CH19_2G6_302_VKGxl2C6-HALB098 707. CH19_0-E11xl2C6-HALB098 708. CH19_5-G4xl2C6-HALB098 709. CH19_8-H6xl2C6-HALB098 710. CH19_2-C11xl2C6-HALB098 711. CH19_2-A10xl2C6-HALB098 712. CH19_1-D11xl2C6-HALB098 713. CH19_9-F9xl2C6-HALB098 714. CH19_1-H8xl2C6-HALB098 715. CH19_1-B12xl2C6-HALB098 716. CH19_0-C4xl2C6-HALB098 717. CH19_3-F2xl2C6-HALB098 718. CH19_3-B10xl2C6-HALB098 719. CH19_0-G4xl2C6-HALB098 720. CH19_0-H5xl2C6-HALB098 721. CH19_0-B8xl2C6-HALB098 722. CH19_2-D9xl2C6-HALB098 723. CH19_8-H7xl2C6-HALB098 724. CH19_9-C2xl2C6-HALB098 725. CH19_3-D5xl2C6-HALB098 726. CH19_1-G11xl2C6-HALB098 727. CH19_1-H11xl2C6-HALB098 728. CH19_9-F3xl2C6-HALB098 729. CH19_2-G6xl2C6-HALB098 730. CH19_2-H7xl2C6-HALB098 731. CH19_5-B3xl2C6-HALB098 732. CH19_5-E10xl2C6-HALB098 733. CH19_6-G10xl2C6-HALB098 734. CH19_4-H8xl2C6-HALB098 735. CH19_2-E4xl2C6-HALB098 736. CH19_6-B8xl2C6-HALB098 737. CH19_0-B4xl2C6-HALB098 738. CH19_9-F1xl2C6-HALB098 739. CH19_4-A7xl2C6-HALB098 740. CH19_6-E12xl2C6-HALB098 741. CH19_6-C12xl2C6-HALB098 742. CH19_6-A7xl2C6-HALB098 743. CH19_6-G8xl2C6-HALB098 744. CH19_6-F9xl2C6-HALB098 745. CH19_0-C11xl2C6-HALB098 746. CH19_8-F6xl2C6-HALB098 747. CH19_0-G9xl2C6-HALB098 748. CH19_1-E11xl2C6-HALB098 749. CH19_0-F5xl2C6-HALB098 750. CH19_1-E1xl2C6-HALB098 751. CH19_1-E6xl2C6-HALB098 752. CH19_2G6_302xl2C6-HALB098 753. CH19_2G6_302_VKGxl2C6-HALB114 754. CH19_0-E11xl2C6-HALB114 755. CH19_5-G4xl2C6-HALB114 756. CH19_8-H6xl2C6-HALB114 757. CH19_2-C11xl2C6-HALB114 758. CH19_2-A10xl2C6-HALB114 759. CH19_1-D11xl2C6-HALB114 760. CH19_9-F9xl2C6-HALB114 761. CH19_1-H8xl2C6-HALB114 762. CH19_1-B12xl2C6-HALB114 763. CH19_0-C4xl2C6-HALB114 764. CH19_3-F2xl2C6-HALB114 765. CH19_3-B10xl2C6-HALB114 766. CH19_0-G4xl2C6-HALB114 767. CH19_0-H5xl2C6-HALB114 768. CH19_0-B8xl2C6-HALB114 769. CH19_2-D9xl2C6-HALB114 770. CH19_8-H7xl2C6-HALB114 771. CH19_9-C2xl2C6-HALB114 772. CH19_3-D5xl2C6-HALB114 773. CH19_1-G11xl2C6-HALB114 774. CH19_1-H11xl2C6-HALB114 775. CH19_9-F3xl2C6-HALB114 776. CH19_2-G6xl2C6-HALB114 777. CH19_2-H7xl2C6-HALB114 778. CH19_5-B3xl2C6-HALB114 779. CH19_5-E10xl2C6-HALB114 780. CH19_6-G10xl2C6-HALB114 781. CH19_4-H8xl2C6-HALB114 782. CH19_2-E4xl2C6-HALB114 783. CH19_6-B8xl2C6-HALB114 784. CH19_0-B4xl2C6-HALB114 785. CH19_9-F1xl2C6-HALB114 786. CH19_4-A7xl2C6-HALB114 787. CH19_6-E12xl2C6-HALB114 788. CH19_6-C12xl2C6-HALB114 789. CH19_6-A7xl2C6-HALB114 790. CH19_6-G8xl2C6-HALB114 791. CH19_6-F9xl2C6-HALB114 792. CH19_0-C11xl2C6-HALB114 793. CH19_8-F6xl2C6-HALB114 794. CH19_0-G9xl2C6-HALB114 795. CH19_1-E11xl2C6-HALB114 796. CH19_0-F5xl2C6-HALB114 797. CH19_1-E1xl2C6-HALB114 798. CH19_1-E6xl2C6-HALB114 799. CH19_2G6_302xl2C6-HALB114 800. CH19_2G6_302_VKGxl2C6-HALB254 801. CH19_0-E11xl2C6-HALB254 802. CH19_5-G4xl2C6-HALB254 803. CH19_8-H6xl2C6-HALB254 804. CH19_2-C11xl2C6-HALB254 805. CH19_2-A10xl2C6-HALB254 806. CH19_1-D11xl2C6-HALB254 807. CH19_9-F9xl2C6-HALB254 808. CH19_1-H8xl2C6-HALB254 809. CH19_1-B12xl2C6-HALB254 810. CH19_0-C4xl2C6-HALB254 811. CH19_3-F2xl2C6-HALB254 812. CH19_3-B10xl2C6-HALB254 813. CH19_0-G4xl2C6-HALB254 814. CH19_0-H5xl2C6-HALB254 815. CH19_0-B8xl2C6-HALB254 816. CH19_2-D9xl2C6-HALB254 817. CH19_8-H7xl2C6-HALB254 818. CH19_9-C2xl2C6-HALB254 819. CH19_3-D5xl2C6-HALB254 820. CH19_1-G11xl2C6-HALB254 821. CH19_1-H11xl2C6-HALB254 822. CH19_9-F3xl2C6-HALB254 823. CH19_2-G6xl2C6-HALB254 824. CH19_2-H7xl2C6-HALB254 825. CH19_5-B3xl2C6-HALB254 826. CH19_5-E10xl2C6-HALB254 827. CH19_6-G10xl2C6-HALB254 828. CH19_4-H8xl2C6-HALB254 829. CH19_2-E4xl2C6-HALB254 830. CH19_6-B8xl2C6-HALB254 831. CH19_0-B4xl2C6-HALB254 832. CH19_9-F1xl2C6-HALB254 833. CH19_4-A7xl2C6-HALB254 834. CH19_6-E12xl2C6-HALB254 835. CH19_6-C12xl2C6-HALB254 836. CH19_6-A7xl2C6-HALB254 837. CH19_6-G8xl2C6-HALB254 838. CH19_6-F9xl2C6-HALB254 839. CH19_0-C11xl2C6-HALB254 840. CH19_8-F6xl2C6-HALB254 841. CH19_0-G9xl2C6-HALB254 842. CH19_1-E11xl2C6-HALB254 843. CH19_0-F5xl2C6-HALB254 844. CH19_1-E1xl2C6-HALB254 845. CH19_1-E6xl2C6-HALB254 846. CH19_2G6_302xl2C6-HALB254 847. CH19_2G6_302_VKGxl2C6-CH-FcB-LH 848. CH19_0-E11xl2C6-CH-FcB-LH 849. CH19_5-G4xl2C6-CH-FcB-LH 850. CH19_8-H6xl2C6-CH-FcB-LH 851. CH19_2-C11xl2C6-CH-FcB-LH 852. CH19_2-A10xl2C6-CH-FcB-LH 853. CH19_1-D11xl2C6-CH-FcB-LH 854. CH19_9-F9xl2C6-CH-FcB-LH 855. CH19_1-H8xl2C6-CH-FcB-LH 856. CH19_1-B12xl2C6-CH-FcB-LH 857. CH19_0-C4xl2C6-CH-FcB-LH 858. CH19_3-F2xl2C6-CH-FcB-LH 859. CH19_3-B10xl2C6-CH-FcB-LH 860. CH19_0-G4xl2C6-CH-FcB-LH 861. CH19_0-H5xl2C6-CH-FcB-LH 862. CH19_0-B8xl2C6-CH-FcB-LH 863. CH19_2-D9xl2C6-CH-FcB-LH 864. CH19_8-H7xl2C6-CH-FcB-LH 865. CH19_9-C2xl2C6-CH-FcB-LH 866. CH19_3-D5xl2C6-CH-FcB-LH 867. CH19_1-G11xl2C6-CH-FcB-LH 868. CH19_1-H11xl2C6-CH-FcB-LH 869. CH19_9-F3xl2C6-CH-FcB-LH 870. CH19_2-G6xl2C6-CH-FcB-LH 871. CH19_2-H7xl2C6-CH-FcB-LH 872. CH19_5-B3xl2C6-CH-FcB-LH 873. CH19_5-E10xl2C6-CH-FcB-LH 874. CH19_6-G10xl2C6-CH-FcB-LH 875. CH19_4-H8xl2C6-CH-FcB-LH 876. CH19_2-E4xl2C6-CH-FcB-LH 877. CH19_6-B8xl2C6-CH-FcB-LH 878. CH19_0-B4xl2C6-CH-FcB-LH 879. CH19_9-F1xl2C6-CH-FcB-LH 880. CH19_4-A7xl2C6-CH-FcB-LH 881. CH19_6-E12xl2C6-CH-FcB-LH 882. CH19_6-C12xl2C6-CH-FcB-LH 883. CH19_6-A7xl2C6-CH-FcB-LH 884. CH19_6-G8xl2C6-CH-FcB-LH 885. CH19_6-F9xl2C6-CH-FcB-LH 886. CH19_0-C11xl2C6-CH-FcB-LH 887. CH19_8-F6xl2C6-CH-FcB-LH 888. CH19_0-G9xl2C6-CH-FcB-LH 889. CH19_1-E11xl2C6-CH-FcB-LH 890. CH19_0-F5xl2C6-CH-FcB-LH 891. CH19_1-E1xl2C6-CH-FcB-LH 892. CH19_1-E6xl2C6-CH-FcB-LH 893. CH19_2G6_302xl2C6-CH-FcB-LH 894. CH19_2G6_302_VKGxl2C6-CH-FcB-LY 895. CH19_0-E11xl2C6-CH-FcB-LY 896. CH19_5-G4xl2C6-CH-FcB-LY 897. CH19_8-H6xl2C6-CH-FcB-LY 898. CH19_2-C11xl2C6-CH-FcB-LY 899. CH19_2-A10xl2C6-CH-FcB-LY 900. CH19_1-D11xl2C6-CH-FcB-LY 901. CH19_9-F9xl2C6-CH-FcB-LY 902. CH19_1-H8xl2C6-CH-FcB-LY 903. CH19_1-B12xl2C6-CH-FcB-LY 904. CH19_0-C4xl2C6-CH-FcB-LY 905. CH19_3-F2xl2C6-CH-FcB-LY 906. CH19_3-B10xl2C6-CH-FcB-LY 907. CH19_0-G4xl2C6-CH-FcB-LY 908. CH19_0-H5xl2C6-CH-FcB-LY 909. CH19_0-B8xl2C6-CH-FcB-LY 910. CH19_2-D9xl2C6-CH-FcB-LY 911. CH19_8-H7xl2C6-CH-FcB-LY 912. CH19_9-C2xl2C6-CH-FcB-LY 913. CH19_3-D5xl2C6-CH-FcB-LY 914. CH19_1-G11xl2C6-CH-FcB-LY 915. CH19_1-H11xl2C6-CH-FcB-LY 916. CH19_9-F3xl2C6-CH-FcB-LY 917. CH19_2-G6xl2C6-CH-FcB-LY 918. CH19_2-H7xl2C6-CH-FcB-LY 919. CH19_5-B3xl2C6-CH-FcB-LY 920. CH19_5-E10xl2C6-CH-FcB-LY 921. CH19_6-G10xl2C6-CH-FcB-LY 922. CH19_4-H8xl2C6-CH-FcB-LY 923. CH19_2-E4xl2C6-CH-FcB-LY 924. CH19_6-B8xl2C6-CH-FcB-LY 925. CH19_0-B4xl2C6-CH-FcB-LY 926. CH19_9-F1xl2C6-CH-FcB-LY 927. CH19_4-A7xl2C6-CH-FcB-LY 928. CH19_6-E12xl2C6-CH-FcB-LY 929. CH19_6-C12xl2C6-CH-FcB-LY 930. CH19_6-A7xl2C6-CH-FcB-LY 931. CH19_6-G8xl2C6-CH-FcB-LY 932. CH19_6-F9xl2C6-CH-FcB-LY 933. CH19_0-C11xl2C6-CH-FcB-LY 934. CH19_8-F6xl2C6-CH-FcB-LY 935. CH19_0-G9xl2C6-CH-FcB-LY 936. CH19_1-E11xl2C6-CH-FcB-LY 937. CH19_0-F5xl2C6-CH-FcB-LY 938. CH19_1-E1xl2C6-CH-FcB-LY 939. CH19_1-E6xl2C6-CH-FcB-LY 940. CH19_2G6_302xl2C6-CH-FcB-LY 941. CH19_2G6_302_VKGxl2C6-HALB253 942. CH19_0-E11xl2C6-HALB253 943. CH19_5-G4xl2C6-HALB253 944. CH19_8-H6xl2C6-HALB253 945. CH19_2-C11xl2C6-HALB253 946. CH19_2-A10xl2C6-HALB253 947. CH19_1-D11xl2C6-HALB253 948. CH19_9-F9xl2C6-HALB253 949. CH19_1-H8xl2C6-HALB253 950. CH19_1-B12xl2C6-HALB253 951. CH19_0-C4xl2C6-HALB253 952. CH19_3-F2xl2C6-HALB253 953. CH19_3-B10xl2C6-HALB253 954. CH19_0-G4xl2C6-HALB253 955. CH19_0-H5xl2C6-HALB253 956. CH19_0-B8xl2C6-HALB253 957. CH19_2-D9xl2C6-HALB253 958. CH19_8-H7xl2C6-HALB253 959. CH19_9-C2xl2C6-HALB253 960. CH19_3-D5xl2C6-HALB253 961. CH19_1-G11xl2C6-HALB253 962. CH19_1-H11xl2C6-HALB253 963. CH19_9-F3xl2C6-HALB253 964. CH19_2-G6xl2C6-HALB253 965. CH19_2-H7xl2C6-HALB253 966. CH19_5-B3xl2C6-HALB253 967. CH19_5-E10xl2C6-HALB253 968. CH19_6-G10xl2C6-HALB253 969. CH19_4-H8xl2C6-HALB253 970. CH19_2-E4xl2C6-HALB253 971. CH19_6-B8xl2C6-HALB253 972. CH19_0-B4xl2C6-HALB253 973. CH19_9-F1xl2C6-HALB253 974. CH19_4-A7xl2C6-HALB253 975. CH19_6-E12xl2C6-HALB253 976. CH19_6-C12xl2C6-HALB253 977. CH19_6-A7xl2C6-HALB253 978. CH19_6-G8xl2C6-HALB253 979. CH19_6-F9xl2C6-HALB253 980. CH19_0-C11xl2C6-HALB253 981. CH19_8-F6xl2C6-HALB253 982. CH19_0-G9xl2C6-HALB253 983. CH19_1-E11xl2C6-HALB253 984. CH19_0-F5xl2C6-HALB253 985. CH19_1-E1xl2C6-HALB253 986. CH19_1-E6xl2C6-HALB253 987. CH19_2G6_302xl2C6-HALB253 988. CH19_2G6_302_VKGxl2C6-HALB131 989. CH19_0-E11xl2C6-HALB131 990. CH19_5-G4xl2C6-HALB131 991. CH19_8-H6xl2C6-HALB131 992. CH19_2-C11xl2C6-HALB131 993. CH19_2-A10xl2C6-HALB131 994. CH19_1-D11xl2C6-HALB131 995. CH19_9-F9xl2C6-HALB131 996. CH19_1-H8xl2C6-HALB131 997. CH19_1-B12xl2C6-HALB131 998. CH19_0-C4xl2C6-HALB131 999. CH19_3-F2xl2C6-HALB131 1000. CH19_3-B10xl2C6-HALB131 1001. CH19_0-G4xl2C6-HALB131 1002. CH19_0-H5xl2C6-HALB131 1003. CH19_0-B8xl2C6-HALB131 1004. CH19_2-D9xl2C6-HALB131 1005. CH19_8-H7xl2C6-HALB131 1006. CH19_9-C2xl2C6-HALB131 1007. CH19_3-D5xl2C6-HALB131 1008. CH19_1-G11xl2C6-HALB131 1009. CH19_1-H11xl2C6-HALB131 1010. CH19_9-F3xl2C6-HALB131 1011. CH19_2-G6xl2C6-HALB131 1012. CH19_2-H7xl2C6-HALB131 1013. CH19_5-B3xl2C6-HALB131 1014. CH19_5-E10xl2C6-HALB131 1015. CH19_6-G10xl2C6-HALB131 1016. CH19_4-H8xl2C6-HALB131 1017. CH19_2-E4xl2C6-HALB131 1018. CH19_6-B8xl2C6-HALB131 1019. CH19_0-B4xl2C6-HALB131 1020. CH19_9-F1xl2C6-HALB131 1021. CH19_4-A7xl2C6-HALB131 1022. CH19_6-E12xl2C6-HALB131 1023. CH19_6-C12xl2C6-HALB131 1024. CH19_6-A7xl2C6-HALB131 1025. CH19_6-G8xl2C6-HALB131 1026. CH19_6-F9xl2C6-HALB131 1027. CH19_0-C11xl2C6-HALB131 1028. CH19_8-F6xl2C6-HALB131 1029. CH19_0-G9xl2C6-HALB131 1030. CH19_1-E11xl2C6-HALB131 1031. CH19_0-F5xl2C6-HALB131 1032. CH19_1-E1xl2C6-HALB131 1033. CH19_1-E6xl2C6-HALB131 1034. CH19_2G6_302xl2C6-HALB131 1035. CH19_2G6_302_VKGxl2C6-HALB135 1036. CH19_0-E11xl2C6-HALB135 1037. CH19_5-G4xl2C6-HALB135 1038. CH19_8-H6xl2C6-HALB135 1039. CH19_2-C11xl2C6-HALB135 1040. CH19_2-A10xl2C6-HALB135 1041. CH19_1-D11xl2C6-HALB135 1042. CH19_9-F9xl2C6-HALB135 1043. CH19_1-H8xl2C6-HALB135 1044. CH19_1-B12xl2C6-HALB135 1045. CH19_0-C4xl2C6-HALB135 1046. CH19_3-F2xl2C6-HALB135 1047. CH19_3-B10xl2C6-HALB135 1048. CH19_0-G4xl2C6-HALB135 1049. CH19_0-H5xl2C6-HALB135 1050. CH19_0-B8xl2C6-HALB135 1051. CH19_2-D9xl2C6-HALB135 1052. CH19_8-H7xl2C6-HALB135 1053. CH19_9-C2xl2C6-HALB135 1054. CH19_3-D5xl2C6-HALB135 1055. CH19_1-G11xl2C6-HALB135 1056. CH19_1-H11xl2C6-HALB135 1057. CH19_9-F3xl2C6-HALB135 1058. CH19_2-G6xl2C6-HALB135 1059. CH19_2-H7xl2C6-HALB135 1060. CH19_5-B3xl2C6-HALB135 1061. CH19_5-E10xl2C6-HALB135 1062. CH19_6-G10xl2C6-HALB135 1063. CH19_4-H8xl2C6-HALB135 1064. CH19_2-E4xl2C6-HALB135 1065. CH19_6-B8xl2C6-HALB135 1066. CH19_0-B4xl2C6-HALB135 1067. CH19_9-F1xl2C6-HALB135 1068. CH19_4-A7xl2C6-HALB135 1069. CH19_6-E12xl2C6-HALB135 1070. CH19_6-C12xl2C6-HALB135 1071. CH19_6-A7xl2C6-HALB135 1072. CH19_6-G8xl2C6-HALB135 1073. CH19_6-F9xl2C6-HALB135 1074. CH19_0-C11xl2C6-HALB135 1075. CH19_8-F6xl2C6-HALB135 1076. CH19_0-G9xl2C6-HALB135 1077. CH19_1-E11xl2C6-HALB135 1078. CH19_0-F5xl2C6-HALB135 1079. CH19_1-E1xl2C6-HALB135 1080. CH19_1-E6xl2C6-HALB135 1081. CH19_2G6_302xl2C6-HALB135 1082. CH19_2G6_302_VKGxl2C6-HALB133 1083. CH19_0-E11xl2C6-HALB133 1084. CH19_5-G4xl2C6-HALB133 1085. CH19_8-H6xl2C6-HALB133 1086. CH19_2-C11xl2C6-HALB133 1087. CH19_2-A10xl2C6-HALB133 1088. CH19_1-D11xl2C6-HALB133 1089. CH19_9-F9xl2C6-HALB133 1090. CH19_1-H8xl2C6-HALB133 1091. CH19_1-B12xl2C6-HALB133 1092. CH19_0-C4xl2C6-HALB133 1093. CH19_3-F2xl2C6-HALB133 1094. CH19_3-B10xl2C6-HALB133 1095. CH19_0-G4xl2C6-HALB133 1096. CH19_0-H5xl2C6-HALB133 1097. CH19_0-B8xl2C6-HALB133 1098. CH19_2-D9xl2C6-HALB133 1099. CH19_8-H7xl2C6-HALB133 1100. CH19_9-C2xl2C6-HALB133 1101. CH19_3-D5xl2C6-HALB133 1102. CH19_1-G11xl2C6-HALB133 1103. CH19_1-H11xl2C6-HALB133 1104. CH19_9-F3xl2C6-HALB133 1105. CH19_2-G6xl2C6-HALB133 1106. CH19_2-H7xl2C6-HALB133 1107. CH19_5-B3xl2C6-HALB133 1108. CH19_5-E10xl2C6-HALB133 1109. CH19_6-G10xl2C6-HALB133 1110. CH19_4-H8xl2C6-HALB133 1111. CH19_2-E4xl2C6-HALB133 1112. CH19_6-B8xl2C6-HALB133 1113. CH19_0-B4xl2C6-HALB133 1114. CH19_9-F1xl2C6-HALB133 1115. CH19_4-A7xl2C6-HALB133 1116. CH19_6-E12xl2C6-HALB133 1117. CH19_6-C12xl2C6-HALB133 1118. CH19_6-A7xl2C6-HALB133 1119. CH19_6-G8xl2C6-HALB133 1120. CH19_6-F9xl2C6-HALB133 1121. CH19_0-C11xl2C6-HALB133 1122. CH19_8-F6xl2C6-HALB133 1123. CH19_0-G9xl2C6-HALB133 1124. CH19_1-E11xl2C6-HALB133 1125. CH19_0-F5xl2C6-HALB133 1126. CH19_1-E1xl2C6-HALB133 1127. CH19_1-E6xl2C6-HALB133 1128. CH19_2G6_302xl2C6-HALB133 1129. CH19_2G6_302_VKGxl2C6-CH-FcB-LH-156 1130. CH19_0-E11xl2C6-CH-FcB-LH-156 1131. CH19_5-G4xl2C6-CH-FcB-LH-156 1132. CH19_8-H6xl2C6-CH-FcB-LH-156 1133. CH19_2-C11xl2C6-CH-FcB-LH-156 1134. CH19_2-A10xl2C6-CH-FcB-LH-156 1135. CH19_1-D11xl2C6-CH-FcB-LH-156 1136. CH19_9-F9xl2C6-CH-FcB-LH-156 1137. CH19_1-H8xl2C6-CH-FcB-LH-156 1138. CH19_1-B12xl2C6-CH-FcB-LH-156 1139. CH19_0-C4xl2C6-CH-FcB-LH-156 1140. CH19_3-F2xl2C6-CH-FcB-LH-156 1141. CH19_3-B10xl2C6-CH-FcB-LH-156 1142. CH19_0-G4xl2C6-CH-FcB-LH-156 1143. CH19_0-H5xl2C6-CH-FcB-LH-156 1144. CH19_0-B8xl2C6-CH-FcB-LH-156 1145. CH19_2-D9xl2C6-CH-FcB-LH-156 1146. CH19_8-H7xl2C6-CH-FcB-LH-156 1147. CH19_9-C2xl2C6-CH-FcB-LH-156 1148. CH19_3-D5xl2C6-CH-FcB-LH-156 1149. CH19_1-G11xl2C6-CH-FcB-LH-156 1150. CH19_1-H11xl2C6-CH-FcB-LH-156 1151. CH19_9-F3xl2C6-CH-FcB-LH-156 1152. CH19_2-G6xl2C6-CH-FcB-LH-156 1153. CH19_2-H7xl2C6-CH-FcB-LH-156 1154. CH19_5-B3xl2C6-CH-FcB-LH-156 1155. CH19_5-E10xl2C6-CH-FcB-LH-156 1156. CH19_6-G10xl2C6-CH-FcB-LH-156 1157. CH19_4-H8xl2C6-CH-FcB-LH-156 1158. CH19_2-E4xl2C6-CH-FcB-LH-156 1159. CH19_6-B8xl2C6-CH-FcB-LH-156 1160. CH19_0-B4xl2C6-CH-FcB-LH-156 1161. CH19_9-F1xl2C6-CH-FcB-LH-156 1162. CH19_4-A7xl2C6-CH-FcB-LH-156 1163. CH19_6-E12xl2C6-CH-FcB-LH-156 1164. CH19_6-C12xl2C6-CH-FcB-LH-156 1165. CH19_6-A7xl2C6-CH-FcB-LH-156 1166. CH19_6-G8xl2C6-CH-FcB-LH-156 1167. CH19_6-F9xl2C6-CH-FcB-LH-156 1168. CH19_0-C11xl2C6-CH-FcB-LH-156 1169. CH19_8-F6xl2C6-CH-FcB-LH-156 1170. CH19_0-G9xl2C6-CH-FcB-LH-156 1171. CH19_1-E11xl2C6-CH-FcB-LH-156 1172. CH19_0-F5xl2C6-CH-FcB-LH-156 1173. CH19_1-E1xl2C6-CH-FcB-LH-156 1174. CH19_1-E6xl2C6-CH-FcB-LH-156 1175. CH19_2G6_302xl2C6-CH-FcB-LH-156 1176. CH19_2G6_302_VKGxl2C6-CH-FcB-LY-156 1177. CH19_0-E11xl2C6-CH-FcB-LY-156 1178. CH19_5-G4xl2C6-CH-FcB-LY-156 1179. CH19_8-H6xl2C6-CH-FcB-LY-156 1180. CH19_2-C11xl2C6-CH-FcB-LY-156 1181. CH19_2-A10xl2C6-CH-FcB-LY-156 1182. CH19_1-D11xl2C6-CH-FcB-LY-156 1183. CH19_9-F9xl2C6-CH-FcB-LY-156 1184. CH19_1-H8xl2C6-CH-FcB-LY-156 1185. CH19_1-B12xl2C6-CH-FcB-LY-156 1186. CH19_0-C4xl2C6-CH-FcB-LY-156 1187. CH19_3-F2xl2C6-CH-FcB-LY-156 1188. CH19_3-B10xl2C6-CH-FcB-LY-156 1189. CH19_0-G4xl2C6-CH-FcB-LY-156 1190. CH19_0-H5xl2C6-CH-FcB-LY-156 1191. CH19_0-B8xl2C6-CH-FcB-LY-156 1192. CH19_2-D9xl2C6-CH-FcB-LY-156 1193. CH19_8-H7xl2C6-CH-FcB-LY-156 1194. CH19_9-C2xl2C6-CH-FcB-LY-156 1195. CH19_3-D5xl2C6-CH-FcB-LY-156 1196. CH19_1-G11xl2C6-CH-FcB-LY-156 1197. CH19_1-H11xl2C6-CH-FcB-LY-156 1198. CH19_9-F3xl2C6-CH-FcB-LY-156 1199. CH19_2-G6xl2C6-CH-FcB-LY-156 1200. CH19_2-H7xl2C6-CH-FcB-LY-156 1201. CH19_5-B3xl2C6-CH-FcB-LY-156 1202. CH19_5-E10xl2C6-CH-FcB-LY-156 1203. CH19_6-G10xl2C6-CH-FcB-LY-156 1204. CH19_4-H8xl2C6-CH-FcB-LY-156 1205. CH19_2-E4xl2C6-CH-FcB-LY-156 1206. CH19_6-B8xl2C6-CH-FcB-LY-156 1207. CH19_0-B4xl2C6-CH-FcB-LY-156 1208. CH19_9-F1xl2C6-CH-FcB-LY-156 1209. CH19_4-A7xl2C6-CH-FcB-LY-156 1210. CH19_6-E12xl2C6-CH-FcB-LY-156 1211. CH19_6-C12xl2C6-CH-FcB-LY-156 1212. CH19_6-A7xl2C6-CH-FcB-LY-156 1213. CH19_6-G8xl2C6-CH-FcB-LY-156 1214. CH19_6-F9xl2C6-CH-FcB-LY-156 1215. CH19_0-C11xl2C6-CH-FcB-LY-156 1216. CH19_8-F6xl2C6-CH-FcB-LY-156 1217. CH19_0-G9xl2C6-CH-FcB-LY-156 1218. CH19_1-E11xl2C6-CH-FcB-LY-156 1219. CH19_0-F5xl2C6-CH-FcB-LY-156 1220. CH19_1-E1xl2C6-CH-FcB-LY-156 1221. CH19_1-E6xl2C6-CH-FcB-LY-156 1222. CH19_2G6_302xl2C6-CH-FcB-LY-156 1223. Human Cadherin-19 Construct A 1224. Cyno Cadherin-19 Macaca fascicularis 1225. secreted Cadherin-19 ecto-domain (amino acids 1-596) human 1226. ckCDH19(1-43)::FLAG::ckCDH19(44-776) construct J 1227. huCDH19(1-43)::FLAG::hu(44-141)::ckCDH19(142-776) construct K 1228. ckCDH19(1-43)::FLAG::ckCDH19(44-141)::huCDH19(142-249)::ckCDH19(250-776) construct L 1229. ckCDH19(1-43)::FLAG::ckCDH19(44-249)::huCDH19(250-364)::ckCDH19(365-776) construct M 1230. ckCDH19(1-43)::FLAG::ckCDH19(44-364)::huCDH19(365-463)::ckCDH19(469-776) construct N 1231. (1-43)::FLAG::ckCDH19(44-468)::huCDH19(464-772) construct O 1232. huCDH19(1-43)::FLAG::huCDH19(44-772) 1233. Human CD3ε extracellular domain 1234. Human CD3ε 1-27 1235. Callithrix jacchus CD3ε extracellular domain 1236. Callithrix jacchus CD3ε 1-27 1237. Saguinus oedipus CD3ε extracellular domain 1238. Saguinus oedipus CD3ε 1-27 1239. Saimiri sciureus CD3ε extracellular domain 1240. Saimiri sciureus CD3ε 1-27