A Container for at least a First Injectable Medicament and Injection Device

Abstract

The present disclosure relates to a container (10) for at least a first injectable medicament (60), the container comprising:an elongated body (11) having a tubular-shaped sidewall (12) extending along a longitudinal axis (z) and having a distal end (13), wherein the elongated body (11) comprises a hollow space (15) with a needle receiving subsection (17) adjacent to the distal end (13),an outlet (40) at the distal end (13) of the body (11),a piston (20) arranged inside the elongated body (11), sealingly engaged with the sidewall (12) and slidable along the longitudinal axis (z) relative to the sidewall (12),a membrane (30) arranged inside the elongated body (11) sealingly engaged with the sidewall (12) and being at least one of slidable and deformable along the longitudinal axis (z) relative to the sidewall (12),a first cavity (16) confined by the sidewall (12), the outlet (40) and the membrane (30), wherein the first injectable medicament (60) is located in the first cavity (16),a second cavity (18) confined by the sidewall (12), the piston (20) and the membrane (30), wherein the piston (20) and the membrane (30) are separated from each other by a distance along the longitudinal axis (z),wherein the outlet (40) is configured to receive or to hold a needle (50) extending from the distal end (13) into the needle receiving subsection (17), andwherein in an initial configuration, the membrane (30) is located outside the needle receiving subsection (17) and wherein the membrane (30) is displaceable or deformable relative to the sidewall (12) to such an extent that at least a portion (31) of the membrane (30) enters the needle receiving subsection (17).

Claims

1. A container (10) for at least a first injectable medicament (60), the container comprising: an elongated body (11) having a tubular-shaped sidewall (12) extending along a longitudinal axis (z) and having a distal end (13), wherein the elongated body (11) comprises a hollow space (15) with a needle receiving subsection (17) adjacent to the distal end (13), an outlet (40) at the distal end (13) of the body (11), a piston (20) arranged inside the elongated body (11), sealingly engaged with the sidewall (12) and slidable along the longitudinal axis (z) relative to the sidewall (12), a membrane (30) arranged inside the elongated body (11) sealingly engaged with the sidewall (12) and being at least one of slidable and deformable along the longitudinal axis (z) relative to the sidewall (12), a first cavity (16) confined by the sidewall (12), the outlet (40) and the membrane (30), wherein the first injectable medicament (60) is located in the first cavity (16), a second cavity (18) confined by the sidewall (12), the piston (20) and the membrane (30), wherein the piston (20) and the membrane (30) are separated from each other by a distance along the longitudinal axis (z), wherein the outlet (40) is configured to receive or to hold a needle (50) extending from the distal end (13) into the needle receiving subsection (17), and wherein in an initial configuration, the membrane (30) is located outside the needle receiving subsection (17) and wherein the membrane (30) is displaceable or deformable relative to the sidewall (12) to such an extent that at least a portion (31) of the membrane (30) enters the needle receiving subsection (17).

2. The container (10) according to claim 1, wherein the membrane (30) is pierceable and penetrable by the needle (50).

3. The container (10) according to any one of the preceding claims, wherein at least a second injectable medicament (62) is located in the second cavity (18).

4. The container according to any one of the preceding claims, wherein the membrane (30) is substantially inflexible.

5. The container according to any one of the preceding claims, wherein the membrane (30) comprises at least one or a combination of the following materials: a thermoplastic polymer, a thermoplastic elastomer, a thermoplastic vulcanizate, polyethylene (PE), polyvinyl chloride (PVC), polytetrafluoro-ethylene (PTFE), silicone rubber, halogenated butyl rubber, chlorobutyl rubber, bromobutyl rubber, chemical vapor deposited poly(p-xylylene) polymers, parylene, cork.

6. The container (10) according to any one of the preceding claims, wherein the membrane (30) comprises a thickness in a range from 10 m-2 mm, from 10 m-100 m, from 100 m-2 mm, or from 100 m-1 mm.

7. The container (10) according to any one of the preceding claims, wherein the membrane (30) is substantially impenetrable to liquids.

8. The container (10) according to any one of the preceding claims 3 to 7, wherein the at least first injectable medicament (60) comprises a narcotic active ingredient.

9. The container (10) according to any one of the preceding claims 3 to 8, wherein the first injectable medicament (60) and the second injectable medicament (62) comprise different drug formulations.

10. The container (10) according to any one of the preceding claims 3 to 9, wherein a viscosity of the second injectable medicament (62) is larger than 1.5 mPa s, larger than 3.0 mPa s, larger than 6.0 mPa s, larger than 12.0 mPa s, larger than 20.0 mPa s, or larger than 40 mPa s when measured at room temperature (20 C.).

11. The container (10) according to any one of the preceding claims, wherein the outlet (40) comprises a seal (25) pierceable by the needle (50).

12. An injection device (100) for administering at least a first injectable medicament (60), the injection device (100) comprising a container according to any one of the preceding claims and a needle (50) attached to the outlet (40) of the container (10), wherein the needle (50) comprises a proximal tipped end (51) extending into the needle receiving subsection (17).

13. The injection device according to claim 12, further comprising a plunger (110) configured to exert distally directed pressure to the piston (20).

14. The injection device according to claim 13, wherein the plunger (110) is rigidly connected to the piston (20) to transfer a distally directed and a proximally directed driving force from the plunger (110) to the piston (20).

15. The injection device according to any one of the preceding claims 11 to 14, wherein the needle (50) is displaceable relative to the body (11) of the container (10) along the longitudinal axis (z) between at least two longitudinal positions and wherein the needle (50) is fixable relative to the body (11) in any of the at least two longitudinal positions.

16. The injection device according to any one of the preceding claims 11 to 15, further comprising a housing (120) to accommodate the container (10) and comprising a drive mechanism (104) configured to urge the plunger (110) towards the distal end (13).

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0134] In the following, numerous examples of the container and of an injection device will be described in greater detail by making reference to the drawings, in which:

[0135] FIG. 1 shows an example of an injection device,

[0136] FIG. 2 shows the injection device partially disassembled,

[0137] FIG. 3 shows a distal end of the injection device with a needle assembly attached to an outlet end of the injection device,

[0138] FIG. 4 is a longitudinal cross-section through an example of the container in an initial configuration,

[0139] FIG. 5 represents the container according to FIG. 4 with a needle attached to the outlet,

[0140] FIG. 6 shows the container according to FIG. 5 when the membrane has been pierced by the needle and when delivery of the second injectable medicament takes place,

[0141] FIG. 7 shows a position of the needle that varies from the position of the needle as shown in FIG. 6,

[0142] FIG. 8 is an example of the container after the membrane has been pierced by the needle,

[0143] FIG. 9 shows a configuration of the container according to FIG. 8 after or during withdrawal of the piston in proximal direction,

[0144] FIG. 10 shows a further example of a container with a deformable membrane in an initial configuration and

[0145] FIG. 11 shows the container according to FIG. 10 in a configuration in which a portion of the deformed membrane is pierced by the needle.

DETAILED DESCRIPTION

[0146] In FIGS. 1-3 an example of an injection device 100 configured as a pen type injector is illustrated. The injection device 100 comprises a housing 120. The housing 120 comprises a cartridge holder 121 and a body 122. The cartridge holder 121 is configured to accommodate a container 10 that may comprise a cartridge that is prefilled with at least a first injectable medicament 60. The cartridge holder 121 and the body 122 may be permanently or releasably attached to each other. The injection device 100 may be configured as a disposable injection device with the container 10 readily assembled therein. Alternatively, the injection device 100 may be configured as a reusable device. Here, the cartridge holder 121 can be disconnected from the body 122 in order to replace or to exchange a container 10.

[0147] The cartridge holder 121 as illustrated in FIG. 2 comprises a window 125 in order to allow visual inspection of the container 10 located therein. Near a distal end the cartridge holder 121 comprises a socket 131 having an outer threaded section 132. The socket 131 is configured to engage with a needle assembly 55 which is separately illustrated in FIG. 1. The needle assembly 55 comprises an injection needle 50. The injection needle 50 is a double tipped hollow cannula having a proximal end 51 and a distal end 52 as shown in FIG. 3. The needle assembly 55 also denoted as a needle hub comprises a bottom section 56 and a sidewall section 57. The bottom section 56 and the sidewall section 57 form a cup-shaped receptacle configured to receive the threaded socket 131 of the cartridge holder 121. The sidewall section 57 comprises an inner threaded section 58 that mates with the outer threaded section 132 of the socket 131. A distal end face of the cartridge holder 121 comprises a through opening 123 through which the proximally protruding portion of the needle 50 can extend into the interior of the cartridge holder 121 and hence into the interior of the cartridge or container 10 when the needle assembly 55 is attached to the cartridge holder 121 and when the container 10 is arranged in the cartridge holder 121.

[0148] The container 10 is arranged inside the cartridge holder 121. It is positionally fixed inside the cartridge holder 121. The container 10 may comprise a narrowing shoulder portion 23 to abut or to engage axially with a correspondingly-shaped shoulder section of the cartridge holder 121. The container 10 comprises an elongated and tubular-shaped body 11. The body 11 may comprise a vitreous body. The body 11 may be made of glass. The body may be translucent or transparent in order to allow visual inspection of the content of the container 10. The elongated body 11 extends along a longitudinal direction (z). The body 11 comprises a distal end 13 and an oppositely located proximal end 14 as illustrated in FIG. 4.

[0149] With the distal end the body 11 is arranged near or at the distal end of the cartridge holder 121. The distal end 13 of the body 11 comprises a narrowing shoulder portion 23 extending into a diameter reduced neck portion 22. At the far distal end the neck portion 22 extends into a radially widening head portion 24. At the head portion 24 there is provided a seal 25, e.g. in form of a pierceable sealing disc. This seal 25 may comprise a pierceable rubber septum 26 that is fixed to the head portion 24 and hence to the distal end 13 of the body 11 by means of a crimped cap 27. The seal 25 may form an outlet 40 of the container 10 at the distal end 13 of the elongated body 11.

[0150] The injection device 100 may be further equipped with a drive mechanism 104 comprising a plunger 110 or a piston rod. The drive mechanism 104 may be further equipped with a dose button 108 by way of which a dispensing action of the injection device 100 can be triggered or controlled. Optionally, the injection device 100 and its drive mechanism 104 comprises a dose dial 106 by way of which a size of a dose to be dispensed can be individually set or by way of which the injection device 100 can be deployed or prepared for a subsequent dispensing procedure.

[0151] Optionally and as illustrated in FIG. 1 the body 122 of the housing 120 may be provided with a dose size indicating window 126. In the window 126 the size of a dose actually set can be visually displayed thus informing the user of the amount of the medicament to be dispensed during a subsequent dispensing procedure.

[0152] As further illustrated in FIG. 1 the needle assembly 55 may be provided with an inner needle cap 127 configured to cover the distal end 52 of the injection needle 50. The entire needle assembly 55 may be further covered by an outer needle cap 128. If not in use the needle assembly 55 should be detached from the distal end of the cartridge holder 121. Then the cartridge holder 121 can and should be covered by a protective cap 124. The protective cap 124 is configured to releasably engage with at least one of the cartridge holder 121 and the body 122. Prior to assembling the needle assembly 55 to the cartridge holder 121 the protective cap 124 has to be detached from the housing 120.

[0153] The interaction of the container 10 with a pen type injection device 100 as illustrated in FIGS. 1-3 is only exemplary. The general working principle of the container does not require interaction with a pen type injection device. The container 10 may be used as a manually operated syringe as will be explained below.

[0154] The container 10 in its entirety is illustrated in FIG. 4. The container 10 comprises an elongated body 11 with a tubular-shaped sidewall 12 extending along a longitudinal axis or along an axial direction (z). The container 10 and the elongated body 11 comprise a distal end 13 provided with an outlet 40 for at least a first injectable medicament 60. At an opposite longitudinal end the body 11 comprises a proximal end 14. The elongated body 11 and its tubular-shaped sidewall 12 confine a hollow space 15 of cylindrical geometry. Towards the proximal end 14 the hollow space 15 inside the elongated body 11 is sealed by a piston 20. The piston 20 comprises a diameter that corresponds and matches with the inner cross-section of the sidewall 12. The piston is sealingly engaged with the sidewall 12 and is slidable along the longitudinal axis (z) relative to the sidewall 12.

[0155] At a given axial or longitudinal distance from the piston 20 there is arranged a membrane 30 inside the elongated body. The membrane 30 is also sealingly engaged with the sidewall 12 and is at least one of slidable and deformable along the longitudinal axis (z) relative to the sidewall 12. As seen in longitudinal direction the membrane 30 is located between the piston 20 and the seal 40. The membrane 30 may be located in a longitudinal mid-section of the container 10. The piston 20 may be provided at or near a proximal end 14 of the container 10 and the outlet 40 may be provided at the distal end 13.

[0156] The membrane 30 is substantially impenetrable to liquids or is at least substantially impenetrable to pharmaceutically active ingredients of the at least first medicament 60 and/or of an at least second medicament 62. The hollow space 15 inside the body 11 is separated by the membrane 30 into a first cavity 16 and into a second cavity 18. The first cavity 16 is confined by the sidewall 12, by the outlet 40 and by the membrane 30. The second cavity 18 is confined by the sidewall 12, by the piston 20 and by the membrane 30. As seen in longitudinal direction the first and second cavities 16, 18 are located behind one another.

[0157] Adjacent to the distal end and/or adjacent to the outlet 40 the hollow space 15 of the container 10 comprises a needle receiving subsection 17. The needle receiving subsection is defined by the penetration depth of a needle 50 configured to enter the hollow space 15 from the outlet 40 in the longitudinal direction and towards the proximal end 14. The needle receiving subsection 17 is virtually indicated in FIGS. 4 and 5 by a dashed vertical line. The proximal end of the needle receiving subsection 17 coincides with the longitudinal position of a proximal end 51 of the needle 50 when arranged inside the hollow space 15 as indicated in FIG. 5.

[0158] The axial position of the needle 50 may be variable. In an initial configuration and when delivered to a healthcare professional or to a customer the container 10 may be void of a needle. The container 10 may comprise a cartridge sealed towards the distal end 13 by a pierceable seal 25. For conducting an injection procedure the outlet 40 of the container 10 is provided with a double tipped injection needle 50. In alternative examples the needle 50 may undetachably belong to the container 10 and to the body 11. It may be molded into the body 11 and the container 10. Hence, the needle 50 may be in fluid communication with the first cavity 16 when it is commercially distributed to healthcare professionals or end users.

[0159] The second cavity 18 is typically filled with the second injectable medicament 62. Starting from the configuration as shown in FIG. 5 distally directed pressure may be applied to the piston 20 in order to drive the piston 20 towards the distal end 13. Here, pressure applied to the piston 20 transfers through the second injectable medicament 62 which is substantially incompressible. The rise of a fluid pressure of the second injectable medicament 62 leads to a respective distally directed displacement or deformation of the membrane 30 towards the distal end 13. As a consequence also the pressure inside the first cavity 16 will rise thus leading to the expelling of an amount of the first injectable medicament 60 through the needle 50. If a distal end 52 of the injection needle 50 is located in biological tissue the first injectable medicament 60 will be injected in the biological tissue accordingly.

[0160] In FIG. 6 a situation is illustrated in which the piston 20 has been displaced towards the distal end 13 in unison with the membrane 30. As the membrane 30 enters the needle receiving subsection 17 a portion 31 of the membrane 30 will become pierced and penetrated by the proximal end 51 of the needle 50. Consequently the needle 50 gets in fluid communication with the second cavity 18 and the second injectable medicament 62 provided in the second cavity 18 will become subject to expelling through the needle 50 as the piston 20 is displaced further to the distal end 13. In FIG. 6 also a plunger 110 with a radially widened pressure piece 112 is illustrated by way of which distally directed pressure is exertable onto the piston 20. The plunger 110 may belong to the drive mechanism 104 of an injection device. Alternatively and when the container is implemented as a manually operable syringe the plunger 110 may be manually depressed by a user, e.g. by a thumb of a user. For this the plunger 110 may comprise a radially widening flange 114 at a proximal end onto which a user may apply pressure with a thumb.

[0161] As further illustrated in FIG. 6 a proximal end of the body 11 may be provided with radially outwardly extending lobes 115. There may be provided two diametrically oppositely located lobes 115 or radially outwardly extending flange portion a proximal end section of the body 11. The lobes 115 may provide finger flanges, e.g. for a middle and an index finger of a user in order to apply a counterforce to the container 10 as a user exerts distally directed pressure onto the plunger 110 with a thumb. The lobes 115 may be integrally formed with the container 10. In this case the container 10 and its elongated body 11 may comprise or may be manufactured from an injection molded plastic material. Alternatively, the lobes 115 may be provided as separate components that are fixed to the sidewall 12 of the body. In this case the body 11 may be made of glass.

[0162] In the illustration of FIG. 6 the proximal end 51 of the needle 50 is located at a first position P1. The axial or longitudinal position of the proximal end 51 of the needle 50 determines the axial position at which the membrane 50 is pierced and intersected by the needle 50. As illustrated in FIG. 6 the first cavity 16 comprises a residual non-zero volume as the membrane 30 is pierced by the needle 50. A certain residual amount of the first medicament 60 is hence left inside the container 10 as dispensing and expelling of the second medicament 62 starts. Compared to FIG. 6 the needle 50 and its proximal end 51 are located at a longitudinal position P2 as illustrated in FIG. 7. Here the proximal end 51 of the needle 50 is even further away from the distal end 13 of the body 11 compared to the configuration of FIG. 6.

[0163] As a consequence, the remaining volume of the first cavity 16 is larger in FIG. 7 than in FIG. 6. Insofar, the longitudinal position of the needle 50, in particular of its proximal tipped end 51 governs and determines the total amount of the first injectable medicament to be expelled from the container 10. With a minimum distance of the proximal end 51 of the needle 50 and the outlet 40 or distal end 13 of the body 11 a maximum amount of the first injectable medicament 60 will be expelled through the needle 50. By shortening the distance between the proximal end 51 of the needle 50 and the membrane 30 in an initial configuration the smaller will be the amount of the first injectable medicament expelled through the needle 50. Consequently, with an increasing penetration depth of the needle 50 in longitudinal direction into the hollow space 15 of the container 10 the larger will be the residual amount of the first medicament 60 that remains inside the container 10.

[0164] As the dispensing procedure continues the second injectable medicament 62 is urged and expelled through the injection needle 50 until a configuration as exemplary illustrated in FIG. 8 may be reached. In this configuration also a substantial amount of the second injectable medicament 62 has been expelled through the needle 50. The piston 20 may be even displaced further in distal direction until it is also pierced by the proximal tip 51 of the needle 60. Engagement of the piston 20 with the needle 50 will provide a haptic feedback to a user, that the entirety or that at least a major portion of the second injectable medicament 62 has been expelled and that the injection procedure has terminated.

[0165] The container as illustrated in FIGS. 4-8 is configured for the sequential expelling of two different injectable medicaments 60, 62 at or in the same injection site.

[0166] Furthermore and according to another aspect the container 10 may be also used for biopsy procedures. It may be then only prefilled with the first injectable medicament 60 located inside the first cavity 16. The second cavity 18 may be substantially empty and may be void of the second injectable medicament 62. For the purpose of conducting a biopsy operation there may be provided a gas between the piston 20 and the membrane 30, which under compression is configured to displace or to deform the membrane 30 towards the distal end 13 in order to expel the first injectable medicament 60 as described above in connection with FIGS. 4-7. Instead of a gas there may be provided a spacer inside the second cavity 18. The spacer may separate the piston 20 and membrane 30 in axial direction. It may be sandwiched between the piston 20 and the membrane 30. The spacer, a gas or an inert liquid substance located between the membrane 30 and the piston 20 serves to prevent that the piston 20 is pierced by the needle 50 when the membrane 30 is penetrated by the needle as the membrane 30 and the piston 20 are subject to a longitudinal displacement towards the distal end 13.

[0167] Once the membrane 30 has been penetrated by the proximal end 51 of the needle 50 the piston 20 can be withdrawn and can be displaced or moved towards the proximal end 14 of the body 11 as illustrated in FIG. 9. When withdrawing the piston 20 towards the proximal end 14 a suction effect is generated and a negative pressure is provided in the second cavity 18 thus leading to a withdrawal of tissue and/or of a biological fluid from the piercing site of a patient into the second cavity. The withdrawing and suction of a sample fluid 42 into the second cavity 18 is schematically illustrated in FIG. 9. The plunger 110 and/or its pressure piece 112 is rigidly connected to the piston 20. Here, a connection between the plunger 110 and the piston 20 may comprise a threaded engagement, a magnetic connection, a positive engagement established by snap features or an adhesive connection. Moreover, it is conceivable, that the piston 20 and the elongated plunger 110 are integrally formed.

[0168] In FIGS. 10 and 11 a further configuration of a membrane 30 is illustrated. The container 10 as shown in FIG. 10 in an initial configuration is substantially identical to the container 10 as illustrated and explained with regard to FIGS. 4 and 5. But here and contrary to the container 10 of FIG. 4 the container 10 as illustrated in FIG. 10 comprises a deformable membrane 30. In an initial configuration the proximal end 51 of the needle 50 extends into the first cavity 16. As a distally directed pressure is applied to the piston 20 the fluid pressure inside the second cavity 18 rises which leads to a distally directed deformation and bulging of the membrane 30 as illustrated in FIG. 11.

[0169] The membrane 30 may comprise an elastically deformable material, such as one of several layers of a thermoplastic elastomer. The membrane 30 and its outer circumference may be in frictional engagement with the inside of the sidewall 12. A friction force between the membrane 30 and the sidewall 12 may be substantially larger than a force or pressure required to induce a distally directed deformation of the membrane 30. As the membrane 30 deforms towards the distal end 13 the volume of the first cavity 16 substantially decreases while the volume of the second cavity remains substantially constant. Here, a portion 51, e.g. a radial central portion of the membrane 30 may reach the needle receiving subsection 17 first and may be punctured and penetrated by the proximal tip end 51 of the needle 50 as illustrated in FIG. 11.

[0170] As soon as the portion 31 of the membrane 30 is pierced a fluid transferring connection is established between the hollow interior of the needle 50 and the second cavity 18. As the second injectable medicament 62 flows through the needle 50 the fluid pressure inside the second cavity 18 may decrease thus leading to a relaxation of the membrane 30 such that the pierced portion 31 moves in proximal direction and disengages from the needle 50. A further displacement of the piston 20 in distal direction may then repeatedly lead to an expelling of a certain amount of the first injectable medicament 60 from the first cavity 16 until the portion 31 of the membrane 30 will be pierced again. Since the first and the second injectable medicaments 60, 62 will be subject to a mixing in the pierced tissue temporal variations of the order of expelling of the first and the second injectable medicaments 60, 62 might be tolerable.

[0171] Moreover, if the second medicament 62 comprises a comparatively large viscosity and if the diameter of the needle 50 is comparatively small a comparatively high pressure has to be applied to the piston 20 in distal direction. This pressure may be high enough to keep the membrane 30 in the bulged or deformed configuration as illustrated in FIG. 11. Hence, with a highly viscose second injectable medicament 62 the fluid communication between the second cavity 18 and the needle 50 may persist even after the membrane 30 has been pierced and intersected by the proximal end 51 of the needle 50.

[0172] In some examples or embodiments the membrane 30 might be substantially inflexible. It may exhibit a well-defined sliding behavior with regard to the tubular-shaped sidewall 12. In other embodiments the membrane 30 may be in frictional engagement with the sidewall 12 to such an extent that an elastic membrane 30 tends to deform or to bulge towards the distal end 13 as a respective fluid pressure is applied to the membrane 30. The membrane 30 may be flexible as well as stretchable in order to become pierced by the needle 50 as it is deformed towards the distal end 13.

[0173] Depending on the elastic properties of the material the membrane 30 is made of and depending on the overall geometry, e.g. depending on the thickness of the membrane in longitudinal direction and its diameter or cross-section the membrane 30 may be also subject to a combined sliding movement relative to the sidewall 12 as well as to a bulging or deformation due to a comparatively high pressure in the second cavity 18.

LIST OF REFERENCE NUMBERS

[0174] 10 container [0175] 11 elongated body [0176] 12 sidewall [0177] 13 distal end [0178] 14 proximal end [0179] 15 hollow space [0180] 16 first cavity [0181] 17 needle receiving subsection [0182] 18 second cavity [0183] 20 piston [0184] 22 neck portion [0185] 23 shoulder portion [0186] 24 head portion [0187] 25 seal [0188] 26 septum [0189] 27 cap [0190] 30 membrane [0191] 31 portion [0192] 40 outlet [0193] 42 sample fluid [0194] 50 needle [0195] 51 proximal end [0196] 52 distal end [0197] 55 needle assembly [0198] 56 bottom section [0199] 57 sidewall section [0200] 58 threaded section [0201] 60 medicament [0202] 62 medicament [0203] 100 injection device [0204] 104 drive mechanism [0205] 106 dose dial [0206] 108 dose button [0207] 110 plunger [0208] 112 pressure piece [0209] 114 flange [0210] 115 lobe [0211] 116 connection [0212] 120 housing [0213] 121 cartridge holder [0214] 122 body [0215] 123 through opening [0216] 124 cap [0217] 125 window [0218] 126 window [0219] 127 inner needle cap [0220] 128 outer needle cap [0221] 131 socket [0222] 132 thread