Therapeutic and method of use

Abstract

The present invention is a compound comprising an anti-inflammatory drug component consisting preferably of at least one of an NSAID portion and a cannabis portion and at least one of a progestin component and a progesterone component. The compound may take for instance the form of a pill or pellet (for oral internal use or for subdermal implantation), an injectable solution, or a suppository. The compound is intended for use in treating subjects having or being at increased riskespecially genetically determined riskof developing endometriosis. The compound may also be used for treating other disorders or as a contraceptive.

Claims

1. A method for treating a human suffering from endometriosis or pelvic pain consisting essentially of administering to the human suffering from the endometriosis or the pelvic pain a therapeutically effective amount of a composition consisting essentially of: cannabis; a compound selected from the group consisting of ibuprofen, naproxen, and a combination thereof; and a compound selected from the group consisting of progestin, progesterone, and a combination thereof to treat the endometriosis or the pelvic pain in the human.

2. The method of claim 1, wherein the human has the endometriosis.

3. The method of claim 1, wherein the human suffers from the pelvic pain.

4. The method of claim 1, wherein the composition is formulated as a unit dose.

5. The method of claim 1, wherein the composition is formulated as a pill or pellet.

6. The method of claim 1, wherein the composition is formulated as a suppository.

7. The method of claim 1, wherein the composition is formulated as an injectable solution.

8. The method of claim 1, wherein the composition consists essentially of: the ibuprofen; the cannabis; and the compound selected from the group consisting of: the progestin, the progesterone, and the combination thereof.

9. The method of claim 1, wherein the composition consists essentially of: the naproxen; the cannabis; and the compound selected from the group consisting of: the progestin, the progesterone, and the combination thereof.

10. The method of claim 1, wherein the composition consists essentially of: the ibuprofen and the naproxen; the cannabis; and the compound selected from the group consisting of: the progestin, the progesterone, and the combination thereof.

11. The method of claim 1, wherein the composition consists essentially of: the progestin; the cannabis; and the compound selected from the group consisting of: the ibuprofen, the naproxen, and the combination thereof.

12. The method of claim 1, wherein the composition consists essentially of: the progesterone; the cannabis; and the compound selected from the group consisting of the ibuprofen, the naproxen, and the combination thereof.

13. The method of claim 1, wherein the composition consists essentially of: the progestin and the progesterone; the cannabis; and the compound selected from the group consisting of the ibuprofen, the naproxen, and the combination thereof.

14. The method of claim 1, wherein the method consists essentially of treating the human for the endometriosis.

15. The method of claim 1, wherein the method consists essentially of treating the human for the pelvic pain.

Description

DETAILED DESCRIPTION OF THE INVENTION

(1) Reference throughout this specification to one embodiment, an embodiment, or similar language means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention. Thus, appearances of the phrases in one embodiment, in an embodiment, and similar language throughout this specification may, but do not necessarily, all refer to the same embodiment.

(2) Furthermore, the described features, structures, or characteristics of the invention may be combined in any suitable manner in one or more embodiments. In the following description, numerous specific details are included to provide a thorough understanding of embodiments of the invention. One skilled in the relevant art will recognize, however, that the invention can be practiced without one or more of the specific details, or with other methods, components, materials, and so forth. In other instances, well-known structures, materials, or operations are not shown or described in detail to avoid obscuring aspects of the invention.

(3) A first embodiment of the invention is a therapeutic compound for use in treating endometriosis and like disorders and preferably in pill form comprising a compound including at least one of an NSAID component and a cannabis component and at least one of a progestin component and a progesterone component. In practice, a subject being determined to have endometriosis or at increased risk of developing endometriosis, and more especially being determined to be genetically predisposed to increased risk of developing endometriosis, is orally administered a therapeutically effective amount of the compound so as to alleviate, cure, or prevent the symptoms of endometriosis. The therapeutic compound may be likewise administered for use as a contraceptive.

(4) A second embodiment of the invention is a therapeutic compound for use in treating endometriosis and like disorders and preferably in pellet form comprising a compound including at least one of an NSAID component and a cannabis component and at least one of a progestin component and a progesterone component. In practice, a subject being determined to have endometriosis or at increased risk of developing endometriosis, and more especially being determined to be genetically predisposed to increased risk of developing endometriosis, is administered a therapeutically effective amount of the compound by implanting the compound subdermally into the subject so as to alleviate, cure, or prevent the symptoms of endometriosis. The therapeutic compound may be likewise administered for use as a contraceptive.

(5) A third embodiment of the invention is a therapeutic compound for use in treating endometriosis and like disorders and preferably in solution form comprising a compound including at least one of an NSAID component and a cannabis component and at least one of a progestin component and a progesterone component. In practice, a subject being determined to have endometriosis or at increased risk of developing endometriosis, and more especially being determined to be genetically predisposed to increased risk of developing endometriosis, is administered a therapeutically effective amount of the compound by injecting the compound subdermally into the subject so as to alleviate, cure, or prevent the symptoms of endometriosis. The therapeutic compound may be likewise administered for use as a contraceptive.

(6) A fourth embodiment of the invention is a therapeutic compound for use in treating endometriosis and like disorders and preferably in suppository form comprising a compound including at least one of an NSAID component and a cannabis component and at least one of a progestin component and a progesterone component. In practice, a subject being determined to have endometriosis or at increased risk of developing endometriosis, and more especially being determined to be genetically predisposed to increased risk of developing endometriosis, is administered a therapeutically effective amount of the compound by placing the compound into a body orifice of the subject (e.g. vaginally or rectally) so as to alleviate, cure, or prevent the symptoms of endometriosis. The therapeutic compound may be likewise administered for use as a contraceptive.

(7) It shall be noted that the progestin disclosed herein may include any of a first generation progestin (estrane) including norethindrone, norethynodrel, norethindrone acetate, and ethynodiol diacetate, a second generation progestin (gonane) including levonorgestrel, norethisterone, and norgestrel, a third generation progestin (gonane) including desogestrel, gestodene, norgestimate, drospirenone, and a fourth generation progestin including dienogest, nestorone, nomegestrol acetate, and trimegestone. It shall also be noted that the progesterone disclosed herein may include tanaproget. It shall also be noted that the cannabis component is preferably free of a THC portion. It shall also be noted that the cannabis component may include any of a nabilone, dronabinol, and nabiximols. It shall also be noted that the NSAID disclosed herein may include any of a salicylate including aspirin (acetylsalicylic acid), diflunisal, and salsalate, a propionic acid derivative including ibuprofen, dexibuprofen, naproxen, fenoprofen, ketoprofen, dexketoprofen, flurbiprofen, oxaprozin, and loxoprofen, an acetic acid derivative including indomethacin, tolmetin, sulindac, etodolac, ketorolac, diclofenac, and nabumetone, an enolic acid (oxicam) derivative including piroxicam, meloxicam, tenoxicam, droxicam, lornoxicam, and isoxicam, a fenamic acid derivative (fenamates) including efenamic acid, meclofenamic acid, flufenamic acid, and tolfenamic acid, a selective COX-2 inhibitor (Coxibs) including celecoxib, rofecoxib, valdecoxib, parecoxib, lumiracoxib, etoricoxib, and firocoxib (used in dogs and horses), a sulphonanilide including nimesulide, an other NSAID including licofelone (acts by inhibiting LOX (lipooxygenase) & COX and hence known as LOX/COX inhibitor) and lysine clonixinate, and a natural NSAID including hyperforin, figwort, and calcitriol (vitamin D). It shall also be noted that the compound disclosed herein may include a biologic component including AMPION. It shall also be noted that the therapeutic compound disclosed herein is also useful in increasing dosage accuracy and administration convenience as compared to concurrent administration of separate NSAID and progestin and/or progesterone components.

(8) An exemplary therapeutic compound conforming with any of the disclosed embodiments may comprise for instance a compound including at least one of nabilone, dronabinol, and nabiximols, and at least one of a progestin component and a progesterone component and optionally at least one of naproxen, meloxicam, and celecoxi. A further exemplary therapeutic compound conforming with any of the disclosed embodiments may comprise for instance a compound including at least one of nabilone, dronabinol, and nabiximols and at least one of a progestin component and a progesterone component and optionally at least one of piroxicam, sulindac, and nabumetone. Still further an exemplary therapeutic compound conforming with any of the disclosed embodiments may comprise for instance a compound including 200 to 400 mg (milligrams) of nabilone and 250 to 450 g (micrograms) of norethindrone preferably administered as a once daily dosage. Still further an exemplary therapeutic compound conforming with any of the disclosed embodiments may comprise for instance a compound including 200 to 400 mg (milligrams) of nabilone and 250 to 450 g (micrograms) of norethindrone preferably administered as a once daily dosage. Still further an exemplary therapeutic compound conforming with any of the disclosed embodiments may comprise for instance a compound including approximately 300 mg of nabilone and approximately 350 g of norethindrone preferably administered as a once daily dosage.

(9) The present invention may be embodied in other specific forms without departing from its spirit or essential characteristics. The described embodiments are to be considered in all respects only as illustrative and not restrictive. The scope of the invention is, therefore, indicated by the appended claims rather than by the foregoing description. All changes which come within the meaning and range of equivalency of the claims are to be embraced within their scope.