COMPOSITIONS FOR WOUND TREATMENT

Abstract

A wound treatment composition comprises honey and a gelling agent dispersed in water, and forms a gel on contact with wound exudate. The composition may be prepared by dispersing the gelling agent in water and mixing the water and gelling agent mixture with honey. A kit comprises the wound treatment composition and a secondary dressing.

Claims

1. A wound treatment composition comprising honey and a gelling agent, the honey and gelling agent being dispersed in water, wherein the wound treatment composition forms a gel on contact with wound exudate.

2. A wound treatment composition according to claim 1, wherein the water used to prepare the composition accounts for between about 5% and about 75% w/w of the composition.

3. A wound treatment composition according to claim 2, wherein the water used to prepare the composition accounts for between about 10% and about 50% w/w of the composition.

4. A wound treatment composition according to claim 3, wherein the water used to prepare the composition accounts for about 15% and about 25% w/w of the composition.

5. A wound treatment composition according to claim 2, wherein the honey is produced from nectar of plants of the genus Leptospermum.

6. A wound treatment composition according to claim 5, wherein the honey is manuka honey or jelly bush honey.

7. A wound treatment composition according to claim 6, wherein the honey is manuka honey.

8. A wound treatment composition according to claim 1, wherein the honey used to prepare the composition accounts for between about 25% and about 90% w/w of the composition.

9. A wound treatment composition according to claim 8, wherein the honey used to prepare the composition accounts for between about 40% and about 80% w/w of the composition.

10. A wound treatment composition according to claim 9, wherein the honey used to prepare the composition accounts for between about 60% and about 70% w/w of the composition.

11. A wound treatment composition according to claim 1, wherein the gelling agent is an alginate or pectin.

12. A wound treatment composition according to claim 11, wherein the gelling agent is an alginate.

13. A wound treatment composition according to claim 12, wherein the gelling agent is sodium alginate.

14. A wound treatment composition according to claim 1, wherein the gelling agent is present at a concentration of at least 0.5% w/w.

15. A wound treatment composition according to claim 14, wherein the gelling agent is present at a concentration of at least about 5% w/w.

16. A wound treatment composition according to claim 15, wherein the gelling agent is present at a concentration of at least about 10% w/w.

17. A wound treatment composition according to claim 14, wherein the gelling agent is present at a maximum concentration of 30% w/w.

18. A wound treatment composition according to claim 1, which further comprises one or more additional agents selected from antimicrobial agents, antiseptic agents, antifungal agents, anti-inflammatory agents, vitamins and/or minerals.

19. A wound treatment composition according to claim 18, wherein the one or more additional agents comprise PHMB and/or manuka oil.

20. A wound treatment composition according to claim 19, wherein the one or more additional agents comprise manuka oil.

21. A wound treatment composition according to claim 18, wherein the one or more additional agents are present at a concentration of at least about 0.5% w/w.

22. A wound treatment composition according to claim 18, wherein the one or more additional agents are present at a maximum concentration of 15% w/w.

23. A wound treatment composition according to claim 1, which comprises from about 20% to 40% w/w water, from about 10% to 20% w/w gelling agent, and up to 2% w/w additional antimicrobial agent, the balance of the composition being made up substantially or completely of the components of the honey other than water.

24. A wound treatment composition according to claim 1, which comprises from about 40% to 60% w/w water, from about 3% to 10% w/w gelling agent, and up to 3% w/w additional antimicrobial agent, the balance of the composition being made up substantially or completely of the components of the honey other than water.

25. A wound treatment composition according to claim 23, wherein the additional antimicrobial agent is manuka oil and the honey is manuka honey.

26. A kit comprising a wound treatment composition and a secondary dressing, said wound treatment composition comprising honey and a gelling agent, the honey and gelling agent being dispersed in water, wherein the wound treatment composition forms a gel on contact with wound exudate.

27. A kit according to claim 26, wherein the secondary dressing is an air- and moisture vapour-permeable plastics film.

28. A kit according to claim 27, wherein the air- and moisture vapour-permeable plastics film is a polyurethane film.

29. A method for producing the wound treatment composition of claim 1, comprising the steps of: a) dispersing the gelling agent in water; and b) mixing the water/gelling agent mixture with the honey.

30. A method according to claim 29, wherein in step b) the water/gelling agent mixture is added to the honey.

31. A method according to claim 29, wherein the honey is warmed prior to step b).

32. A method according to claim 29, wherein an additional antimicrobial agent is added to the water and/or to the honey prior to step b).

Description

EXAMPLE 1

[0045]

TABLE-US-00001 Ingredient Mass % w/w Deionised water 15 kg 19.74 Honey 50 kg 65.79 Sodium Alginate 10 kg 13.16 Manuka Oil 1 kg 1.31 TOTAL 76 kg 100%

Manufacturing Method:

[0046] 1. Alginate powder was slowly added to deionised water and mixed at 6000 rpm for 20 minutes using a Silverson Shear Mixer. [0047] 2. Manuka oil was added to the alginate/water mixture. [0048] 3. Honey was heated to 40 C. [0049] 4. The alginate/water/manuka oil mixture from Step 2 was slowly added to the honey from Step 3, and mixed at 6000 rpm for 20 minutes using a Silverson Shear Mixer.

EXAMPLE 2

[0050]

TABLE-US-00002 Ingredient Mass % w/w Deionised water 23.91 kg 47.15 Honey 23.91 kg 47.15 Sodium Alginate 1.89 kg 3.73 Manuka Oil 1 kg 1.97 TOTAL 50.71 kg 100%

Manufacturing Method:

[0051] 1. Alginate powder was slowly added to deionised water and mixed at 6000 rpm for 20 minutes using a Silverson Shear Mixer. [0052] 2. Honey was heated to 40 C. [0053] 3. Manuka oil was slowly added to the honey, and mixed at 6000 rpm for 15 minutes using a Silverson Shear Mixer. [0054] 4. The alginate/water mixture from Step 1 was slowly added to the honey/manuka oil mixture from Step 3, and mixed at 6000 rpm for 20 minutes using a Silverson Shear Mixer.