ABSORBING DEVICE FOR RADIOTHERAPY
20200215354 · 2020-07-09
Inventors
- Christopher Snook (Neusaess, DE)
- Ulrike Lutz (Landsberg, DE)
- Armin Fürst (Geltendorf, DE)
- Florian Weber (Freising, DE)
- Rui Liu (Augsburg, DE)
- Manfred Wiesmeier (Gauting, DE)
Cpc classification
A61N5/1049
HUMAN NECESSITIES
A61N2005/1063
HUMAN NECESSITIES
A47C31/004
HUMAN NECESSITIES
International classification
A61N5/10
HUMAN NECESSITIES
Abstract
An absorbing device (24, 24, 24, 41) for radiotherapy treatment comprising at least one layer of electromagnetic absorbing material wherein the absorbing material is for preventing interaction between a target localisation system (1) having a targeted frequency range of between about 300 kHz and 500 kHz and a treatment table (4).
Claims
1. A mattress for radiotherapy treatment comprising an absorbing device for radiotherapy treatment comprising at least one layer of electromagnetic absorbing material, wherein the absorbing material is for preventing interaction between a target localisation system having a targeted frequency range of between about 300 kHz and 500 kHz and a treatment table, wherein the absorbing device comprises a ferrite layer and at least one spacer layer positioned above the ferrite layer in a patient-facing direction away from the couch top surface on which the patient lies; wherein the ferrite layer comprises a plurality of sheets of a sintered ferrite material.
2. The mattress according to claim 1, further comprising a comfort mattress layer positioned above the ferrite layer in a patient-facing direction away from the couch top surface on which the patient lies.
3. The mattress according to claim 1 wherein the absorbing device comprises an absorber layer comprising a material having high magnetic permeability, wherein the real part of relative permeability () is greater than 200 at 300 kHz and the imaginary part of relative permeability () is less than 50 at 300 kHz.
4. The mattress according to claim 1 wherein the absorbing device comprises an absorber layer having surface resistivity greater than 1.00 E+0.9 Ohms.
5. The mattress according to claim 3 wherein the absorber layer comprises a plurality of stacked sintered ferrite sheets.
6. The mattress according to claim 1 wherein the sintered ferrite material comprises iron oxide (Fe.sub.2O.sub.3); preferably, wherein at least 50% of the total mass of the sintered ferrite material comprises iron oxide (Fe.sub.2O.sub.3); and/or wherein the ferrite material further comprises at least one of Nickel Oxide (NiO); and/or Zinc Oxide (ZnO); and/or Copper Oxide (CuO).
7. The mattress according to claim 1 wherein each sheet of sintered ferrite material has a thickness of between 0.1 mm and 1 mm.
8. The mattress according to claim 1 having a plurality of partially overlapping sheets.
9. The mattress according to claim 1 wherein each sheet is attached to at least one layer of adhesive; preferably, to at least one layer of an adhesive tape.
10. The mattress according to claim 1 wherein the spacer layer includes a reinforcing material such as epoxy, and/or polyester, and/or polymer, polymethacrylimide, and/or vinyl ester resin, and/or wood, and/or ceramic, and/or aramid, and/or glass fibre, and/or ultrahigh molecular weight polyethylene.
11. An absorbing device for radiotherapy treatment, comprising at least one layer of electromagnetic absorbing material, wherein the absorbing material is for preventing interaction between a target localisation system having a targeted frequency range of between about 300 kHz and 500 kHz and a treatment table, wherein the absorbing device comprises a ferrite layer, wherein the ferrite layer comprises a plurality of sheets of a sintered ferrite material, and wherein the absorbing device is for positioning around a patient.
12. The absorbing device according to claim 11 wherein the absorbing device comprises at least two upstanding walls and at least one transverse member therebetween for positioning over and around a patient.
13. A couch top for patient support for radiotherapy treatment comprising a mattress according to claim 1.
14. A couch top for patient support for radiotherapy treatment comprising a mattress according to claim 11.
Description
DETAILED DESCRIPTION
[0071] Example embodiments of the present invention will now be described with reference to the accompanying figures, in which:
[0072]
[0073]
[0074]
[0075]
[0076]
[0077]
[0078]
[0079]
[0080] The present invention is intended to support the use of an electromagnetic tumour tracking system in combination with a carbon-fibre couch top in radiation imaging and therapy.
[0081] Referring to
[0082] Accurate localisation of the target means that the radiation therapist can align the patient's treatment target to the machine isocentre before radiation treatment commences. The use of the wireless beacons 2 and the transceiver 5 also allows for real time monitoring of the patient/target movement during radiotherapy treatment delivery. It is to be understood that the example shown in
[0083] In a preferred embodiment of the present invention, the or each radiofrequency beacon 2 is wireless and does not require a battery. The beacon transponders 2 are self-powered by the magnetic field of the transceiver antenna.
[0084] Referring to
[0085] Referring to
[0086] Unless explicitly specified to the contrary, is to be understood that the term permeability refers to the real part of relative permeability , in the context of the present invention.
[0087] It is to be understood that, in the context of the present invention, high permeability refers to the real part of relative permeability () being greater than 200 at 300 kHz, with a preferred range between 200 and 1000 at 300 kHz. It is to be understood that, in the context of this invention, low loss refers to the imaginary part of relative permeability () being less than 50 at 300 kHz, with a preferred range between 1 and 50 at 300 kHz.
[0088] The material selected for the absorbing device 24 of the present invention was selected to achieve optimum localisation accuracy. It was found that a material having high relative magnetic permeability was well-suited to the present invention. Relative permeability is a complex number and contains both a real part () and an imaginary part () as expressed in Equation 1:
=j[Equation 1]
[0089] The real part refers to the storage capability of the electromagnetic energy and the imaginary part refers to the loss behaviour of the electromagnetic energy. Unless explicitly specified to the contrary, the term permeability refers to the real part of relative permeability , in the context of the present invention. The ideal material for use in the absorbing device 24 comprises a high storage capability () and preserves electromagnetic energy with a low loss component ().
[0090] As shown in
[0091] Various materials were investigated for the absorbing device of the present invention and the localisation errors were quantified for each possible material. Referring to
[0092] The quantitative analysis to arrive at the results shown in
[0093] The preferred material for use in the present invention has a high storage capacity (e.g. is high) and a low loss behaviour (e.g. is low) because this minimises the electromagnetic localisation error. It has also been found that the surface resistance of the absorber layer also affects the electromagnetic field and so the localisation accuracy.
[0094] It is to be understood that in the context of the present invention, the term permeability refers to the real part of relative permeability () and the term permeable materials are the materials with a high real part of relative permeability () value. Both and are strongly dependent on the frequency of the electromagnetic field.
[0102] The results set out in
[0103] Further testing of the absorbing device of the present invention was also carried out to consider potential side effects introduced by ferrite materials. For example, the induced radioactivity effect, dose dosimetry change and the potential for X-ray artefacts were considered. The ferrite material used for the absorbing layer of the present invention comprises a set of ceramic compounds composed of iron oxide (Fe.sub.2O.sub.3) combined chemically with one or more additional metallic elements, including but not limited to copper oxide (CuO), zinc oxide (ZnO) and nickel oxide (NiO).
[0104] Table 1 shows the induced radioactivity (in Sv/hour) with different ferrite material compositions. The tests carried out used an 18 MV beam generator to deliver a photon energy of 96 Gy to several ferrite samples. The induced radioactivity was then measured at the surface of the ferrite material samples. It was found that different ferrite material compositions introduce different radioactivity behaviour and that the induced radioactivity decreases to the previous background level after two hours. Further measurement also shows that both and do not change after radiation. The impact of induced radioactivity can be reduced by placing the ferrite material of the absorbing layer away from the patient's body. In the present invention, a comfort mattress layer and a spacer layer are introduced above the ferrite material layer/s to minimize such induced radioactivity. It is understood that above is in a patient-facing direction away from the couch top surface on which the patient lies.
TABLE-US-00001 TABLE 1 Time after irradiation Sample- Sample- Sample- (minutes) 1 2 3 0 1.8 1.6 0.8 10 1 1 0.5 20 0.6 0.6 0.5 120 0.2 0.2 0.2
[0105] Referring to
[0106] As previously described, the absorber layer 32 comprises a material having high magnetic permeability to avoid the electromagnetic energy dissipation from the transceiver or wireless beacon that may otherwise introduce localisation errors. The absorber layer 32 also comprises a material having a high surface resistivity to provide a significant resistance to current running along the surface of the couch top 34 and the absorbing device 24. In a preferred embodiment, the absorber layer 32 comprises at least one layer of a sintered ferrite material with high magnetic permeability (), high surface resistivity and low loss () to absorb magnetic flux generated from the transceiver 5. The absorber layer 32 has the following characteristics: [0107] >200 at 300 kHz; [0108] <50 at 300 kHz; [0109] surface resistance>1.00E+0.9 Ohms; [0110] ferrite material composition, comprising at least 50% of iron oxide (Fe.sub.2O.sub.3) and, more preferably, also contains Copper oxide (CuO) and/or Zinc oxide (ZnO) and/or Nickel oxide (NiO).
[0111] Referring to
[0112] A multi-layer ferrite panel avoids potential magnetic field saturation due to a large amount of electromagnetic energy generated from the transceiver. As shown in
[0113] In alternative embodiments of the present invention, it is envisaged that the absorbing device 24 comprises an absorber layer 32 having a high magnetic permeability but a low surface resistivity, wherein the absorber layer is modified to compensate for the low surface resistivity; for example, by being provided in small pieces surrounded by an insulating medium. It is envisaged that in this configuration the high magnetic permeability/low surface resistivity material would be usable because the material is modified to reduce the electrical conductivity. In one embodiment of the present invention, the absorber layer of the absorbing device comprises plates/tiles of a ferrite material.
[0114] Referring to
[0115] The vacuum cushion 40 may also comprise at least one bolster (not shown). For example, the bolster can be shaped to locate a shoulder region of the patient in a comfortable, reproducible position for each treatment fraction; or support the knees of the patient in an elevated position; or be a substantially cylindrical neck roll to support underneath a neck of the patient. The use of additional bolsters or cushions reduces patient movement; improves patient comfort and provides better beam access for treatment, if appropriate. Bolsters or cushions can also be used to allow a patient to hold a panic button without introducing unwanted patient movement or increasing patient discomfort.
[0116] With reference to
[0117] Referring to
[0118] With the patient 42 resting on the positioning device 44 and lying in the desired position, the vacuum cushion 40 of the positioning device 44 is connected to a vacuum source or a vacuum pump (not shown) and the gas contained therein is evacuated to compress the filling material and prevent any further movement of the filling or the positioning device 44. Thus, the patient 42 is held by the moulded vacuum cushion 40 of the positioning device 44 in a reproducible position. The vacuum cushion 40 of the patient positioning device 44 is held in a substantially rigid state until the vacuum is broken and the positioning device 44 is returned to a soft and mouldable state to allow the patient to dismount the couch 45.
[0119] As previously described, to allow for patient localisation one or more wireless beacons 46 are positioned in, on or adjacent to the patient 42. The absorbing device 41 of the present invention is incorporated within the positioning device 44 and prevents the introduction of localisation errors in the calculation of the location of the treatment target caused by the surrounding conductive materials and electromagnetic noise. An electromagnetic transceiver 47 is positioned for communication with the wireless markers 46 to allow identification and/or accurate, undistorted positional information to be detected. The transceiver 47 is held in a fixed position or is moveable using a robotic arm (not shown) to move the transceiver 47 into a desired position with respect to the wireless beacons 46 that are to be detected.
[0120] Referring to
[0121] As previously described, with the patient 42 resting on the positioning device 44 and lying in the desired position, the vacuum cushion 40 of the positioning device 44 is connected to a vacuum source or a vacuum pump (not shown) and the gas contained therein is evacuated to compress the filling material and prevent any further movement of the filling or the positioning device 44. In this alternative embodiment, the patient 42 is held by the moulded vacuum cushion positioning device 44 and by the transparent plastic cover sheet 48 in a reproducible position. Both the vacuum cushion 40 and the cover sheet 48 are held in a substantially rigid state until the vacuum is broken. The positioning device 44 is returned to a soft and mouldable state to allow the patient 42 to dismount the couch 45.
[0122] The positioning device of the present invention can be provided to mould to and position the whole of the patient's body; or be provided for a specific body part or region, such as the hip or thorax. It is envisaged that after treatment the plastic sheet 48 can be removed and replaced and the positioning device 44 can be re-inflated and used for positioning of another patient 42.
[0123] The present invention further optimises the mass density and thickness of the absorber layer that is used. A higher mass density and a thicker ferrite absorber layer have been found to result in a greater impact on the dose dosimetry profile. These factors are carefully controlled during manufacture of the absorbing device of the present invention. The present invention also takes into account that different ferrite material compositions result in different attenuation of X-ray imaging. The risk of introducing X-ray artefacts is carefully considered and the nature of the material and the number of ferrite layers used is determined accordingly. For example, an image contrast change at 10.1 mm above the surface of the couch top was introduced when using a single-layer of ferrite material having a thickness of 0.3 mm; whereas, the image contrast change is introduced at 50.0 mm above the surface of the couch top when a laminar absorbing device having five, stacked ferrite panels is used, each having a thickness of 0.3 mm and so a total thickness of 1.5 mm.
[0124] In a further embodiment of the present invention, shown in
[0125] In a further aspect of the present invention, as an alternative or in addition to the pad or mattress accessory solution previously described, the absorbing device of the present invention can be integrated into a couch top or permanently fixed thereto. Thus, the present invention provides a combined solution whereby a carbon couch top is combined with the absorbing device, to offer a solution that is transparent to X-ray radiation; i.e. with very low X-ray attenuation, and maintains the electromagnetic field strength of a localisation system without disconnecting magnetic flux.
[0126] As previously described, the integrated couch top of the present invention comprises an absorber layer combined with an insulation layer. In use, with a patient lying on the couch top, the patient is not directly contacting the absorber layer but is separated therefrom by a non-conductive insulation layer, having a surface resistance greater than 1.00 E-0.9 Ohms. This minimises the induced radioactivity effects and blocks any potential X-ray imaging artefacts generated by the absorber layer. As described with respect to other aspects of the present invention, the insulation layer comprises any one or more of the following materials: epoxy, polyester, polymer, polymethacrylimide, vinyl ester resin, wood, ceramic, aramid, glass fibre or ultrahigh molecular weight polyethylene. The insulation layer provides additional reinforcement to the carbon fibre couch top, increasing the rigidity and loading capacity of the couch top. Furthermore, the insulation layer may comprise a non-conductive foam to act as cushioning and improve patient comfort.
[0127] The integrated couch top comprises an absorber layer having a least one ferrite panel with high magnetic permeability, wherein the real part of relative permeability () is greater than 200 at 300 kHz and the imaginary part of relative permeability () is less than 50 at 300 kHz. It is to understood that the magnetic permeability and the material selected can be further optimised according to the applied magnetic field. The ferrite material used for the absorbing layer of the present invention comprises a set of ceramic compounds composed of iron oxide (Fe.sub.2; O.sub.3); preferably with at least 50% of total ferrite material mass. In further preferred embodiments, the material of the absorber layer is also combined chemically with one or more additional metallic elements, including but not limited to copper oxide (CuO), zinc oxide (ZnO) and nickel oxide (NiO).
[0128] The integrated couch top comprises an absorber layer having a plurality of ferrite sheets; wherein each ferrite sheet has a relatively small size of about 60 cm60 cm and thickness of between about 0.1 mm and 1 mm. Prior to integrating the absorber layer into the couch top, the ferrite sheet is pre-assembled on an adhesive layer to form a larger panel. Preferably, the larger ferrite sheet is supported by a reinforcing layer. For example, the reinforcing carrier layer is rigid and comprises a conductive material, such as carbon fibre, which has very low X-ray attenuation. In alternative embodiments of the integrated couch top, the thickness of the absorber layer is adjusted according to requirements, with stacking of ferrite panels and/or layers to form a thicker layer if required.
[0129] It should be understood that various changes and modifications to the presently preferred embodiments described herein will be apparent to those skilled in the art. Such changes and modifications can be made without departing from the spirit and scope of the present invention and without diminishing its attendant advantages. It is therefore intended that such changes and modifications are covered by the appended claims.
Appendix
[0130] In addition to
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