Combined external medicine for treating prostate diseases

Abstract

The invention provides a combined external medicine for treating prostate diseases and a method using the same. The combined external medicine includes a pre-immune composition comprising multi-immune powder and a noble bottle tree decoction, a lesion active composition comprising the multi-immune powder and a first medical decoction prepared from a first Chinese medical composition for treating prostate diseases, and a double rib active composition comprising the multi-immune powder and a second medical decoction prepared from a second Chinese medical composition for conditioning liver and kidney. The method includes applying the pre-immune composition on skin of lesion part and skin of the left and right ribs; waiting for 5-10 minutes; applying the lesion active composition and the double rib active composition on the skin of the lesion part and skin of the left and right ribs; and airing for 10-40 minutes.

Claims

1. A combined external medicine for treating prostate diseases, comprising: a pre-immune composition comprising a i26 immune egg powder and a noble bottle tree decoction; a lesion active composition comprising the i26 immune egg powder and a first medical decoction prepared from a first Chinese medical composition for treating prostate diseases; and a double rib active composition comprising the i26 immune egg powder and a second medical decoction prepared from a second Chinese medical composition for conditioning liver and kidney wherein the i26 immune egg powder and the noble bottle tree decoction of the pre-immune composition are in a weight ratio of 30-40:60-70; the i26 immune egg powder and the first Chinese medical composition of the lesion active composition are in a weight ratio of 30-40:60-70; and the i26 immune egg powder and the second Chinese medical composition of the double rib active composition are in a weight ratio of 30-40:60-70.

2. The composition of claim 1, wherein the second Chinese medical composition for conditioning liver and kidney comprises a first ingredient, a second ingredient, or a third ingredient, wherein the first ingredient comprises: 15-30 parts by weight of radix rehmanniae, 15-30 parts by weight of rehmanniae vaporata, or 15-30 parts by weight of a mixture of radix rehmanniae and rehmanniae vaporata in a weight ratio of 1:1; 10-20 parts by weight of fructus corni; 15-30 parts by weight of rhizoma dioscoreae; 6-12 parts by weight of cortex moutan; 6-12 parts by weight of poria cocos; 6-12 parts by weight of rhizoma alismatis; 10-20 parts by weight of cuscuta chinensis lam; 10-20 parts by weight of semen astragali complanati; and 10-20 parts by weight of rhizoma polygonati; and the second ingredient comprises: 15-30 parts by weight of radix rehmanniae, 15-30 parts by weight of rehmanniae vaporata, or 15-30 parts by weight of a mixture of radix rehmanniae and rehmanniae vaporata in a weight ratio of 1:1; 10-20 parts by weight of fructus corni; 15-30 parts by weight of rhizoma dioscoreae; 6-12 parts by weight of cortex moutan; 6-12 parts by weight of poria cocos; 6-12 parts by weight of rhizoma alismatis; 15-30 parts by weight of rhizoma anemarrhenae; and 15-30 parts by weight of cortex phellodendri; and the third ingredient comprises: 15-30 parts by weight of radix rehmanniae, 15-30 parts by weight of rehmanniae vaporata, or 15-30 parts by weight of a mixture of radix rehmanniae and rehmanniae vaporata in a weight ratio of 1:1; 10-20 parts by weight of fructus corni; 15-30 parts by weight of rhizoma dioscoreae; 6-12 parts by weight of cortex moutan; 6-12 parts by weight of poria cocos; 6-12 parts by weight of rhizoma alismatis; 10-20 parts by weight of rhizoma polygonati; 10-20 parts by weight of morindae officinalis; 10-30 parts by weight of herba epimedii; 10-30 parts by weight of cortex cinnamomi; and 10-30 parts by weight of radix paeoniae alba.

3. The composition of claim 2, wherein the first Chinese medical composition comprises: 15-30 parts by weight of leech; 20-40 parts by weight of earthworm; 15-30 parts by weight of eupolyphaga; 20-50 parts by weight of fructus foeniculi; 20-40 parts by weight of concha ostreae; 10-20 parts by weight of pangolin scales; 20-40 parts by weight of carapax trionycis; 15-30 parts by weight of radix achyranthis bidentatae; 20-40 parts by weight of rhizoma sparganii; 20-40 parts by weight of rhizoma curcumae; 15-30 parts by weight of radix notoginseng; 20-40 parts by weight of litchi chinensis sonn, 20-60 parts by weight of caulis spatholobi; 20-40 parts by weight of chinese honeylocust spine; 20-40 parts by weight of dandelion; 15-30 parts by weight of myrrh; 15-30 parts by weight of frankincense; 15-30 parts by weight of acacia catechu; 20-40 parts by weight of semen plantaginis; 20-40 parts by weight of hedyotis diffusa; 20-40 parts by weight of tangerine seed; 20-40 parts by weight of cyrtomium fortunei; 15-30 parts by weight of rhizoma chuanxiong; and 15-30 parts by weight of prunella vulgaris.

4. The composition of claim 2, wherein the first Chinese medical composition comprises: 10-30 parts by weight of cortex phellodendri; 10-30 parts by weight of rhizoma anemarrhenae; 5-15 parts by weight of pangolin scales; 10-20 parts by weight of carapax trionycis; 10-30 parts by weight of concha ostreae; 10-30 parts by weight of radix achyranthis bidentatae; 20-50 parts by weight of lysimachia christinae hance; 10-30 parts by weight of fructus crataegi; 10-30 parts by weight of rhizoma curcumae; 10-30 parts by weight of semen plantaginis; 10-40 parts by weight of caulis spatholobi; 20-40 parts by weight of herba leonuri; 10-30 parts by weight of rheum officinale; 10-30 parts by weight of chinese honeylocust spine; 10-30 parts by weight of acacia catechu; 10-30 parts by weight of leech; 10-30 parts by weight of lumbricus; 10-30 parts by weight of eupolyphaga; 15-50 parts by weight of largehead atractylodes rhizome; 10-30 parts by weight of rhizoma chuanxiong; and 10-30 parts by weight of prunella vulgaris.

5. A method for treating prostate diseases by administering the composition of claim 1, comprising: applying the pre-immune composition on skin of lesion part and skin of the left and right ribs; waiting for 5-10 minutes; applying the lesion active composition and the double rib active composition on the skin of the lesion part and skin of the left and right ribs respectively; and airing for 10-40 minutes.

6. The method of claim 5, wherein the composition of claim 1 is used in the morning and in the evening.

7. The method of claim 5, wherein the lesion part is skin of perineum and testis.

Description

DESCRIPTION OF THE EMBODIMENTS

(1) I. Combined External Medicine for Treating Prostatitis

Example 1 (Kidney Yin Deficiency)

(2) 1. Preparation of Combined External Medicine:

(3) 1) Preparation of Traditional Chinese Medicinal Materials:

(4) Preparation of 100 g of noble bottle tree (Sterculia nobilis);

(5) Preparation of therapeutic traditional Chinese medicinal materials for prostatitis: 15 g of leech, 20 g of lumbricus, 15 g of eupolyphaga, 20 g of fructus foeniculi, 20 g of concha ostreae, 10 g of pangolin scales, 20 g of carapax trionycis, 15 g of radix achyranthis bidentatae, 20 g of rhizoma sparganii, 20 g of rhizoma curcumae, 15 g of radix notoginseng, 20 g of litchi chinensis sonn, 20 g of caulis spatholobi, 20 g of chinese honeylocust spine, 20 g of dandelion, 15 g of myrrh, 15 g of frankincense, 15 g of acacia catechu, 20 g of semen plantaginis, 20 g of hedyotis diffusa, 20 g of tangerine seed, 20 g of cyrtomium fortunei, 15 g of rhizoma chuanxiong, and 15 g of prunella vulgaris.

(6) Preparation of traditional Chinese medicinal materials for conditioning kidney yin deficiency: 15 g of radix rehmanniae, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of cuscuta chinensis lam, 10 g of semen astragali complanati and 10 g of rhizoma polygonati.

(7) 2) The above three kinds of medicinal materials were decocted for 40-50 minutes into a decoction, and then concentrated over a high heat to a suitable amount, and cooled to 0 C. to 30 C. to obtain a noble bottle tree decoction, a first medical decoction for treating prostatis, and a second medical decoction for conditioning liver and kidney;

(8) 3) the noble bottle tree decoction, the first medical decoction for treating prostatis, and the second medical decoction for conditioning liver and kidney were respectively mixed with multi-immune powder according to a weight ratio of 38:62 to obtain a pre-immune composition, a lesion active composition, and a double rib active composition.

Example 2 (Kidney Yin Deficiency)

(9) Preparation of traditional Chinese medicinal materials for conditioning kidney yin deficiency: 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of cuscuta chinensis lam, 10 g of semen astragali complanati and 10 g of rhizoma polygonati.

(10) Others are the same as in Example 1.

Example 3 (Kidney Yin Deficiency)

(11) Preparation of traditional Chinese medicinal materials for conditioning kidney yin deficiency: 15 g of radix rehmanniae, 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of cuscuta chinensis lam, 10 g of semen astragali complanati and 10 g of rhizoma polygonati.

(12) Others are the same as in Example 1.

Example 4 (Fire Hyperactivity Due to Kidney Yin Deficiency)

(13) Preparation of therapeutic traditional Chinese medicinal materials for prostatitis: 30 g of leech, 40 g of lumbricus, 30 g of eupolyphaga, 50 g of fructus foeniculi, 40 g of concha ostreae, 20 g of pangolin scales, 40 g of carapax trionycis, 30 g of radix achyranthis bidentatae, 40 g of rhizoma sparganii, 40 g of rhizoma curcumae, 30 g of radix notoginseng, 40 g of litchi chinensis sonn, 60 g of caulis spatholobi, 40 g of chinese honeylocust spine, 40 g of dandelion, 30 g of myrrh, 30 g of frankincense, 30 g of acacia catechu, 40 g of semen plantaginis, 40 g of hedyotis diffusa, 40 g of tangerine seed, 40 g of cyrtomium fortunei, 30 g of rhizoma chuanxiong, and 30 g of prunella vulgaris.

(14) Preparation of traditional Chinese medicinal materials for conditioning fire hyperactivity due to kidney yin deficiency: 15 g of radix rehmanniae, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 15 g of rhizoma anemarrhenae and 15 g of cortex phellodendri.

(15) Others are the same as in Example 1.

Example 5 (Fire Hyperactivity Due to Kidney Yin Deficiency)

(16) Preparation of traditional Chinese medicinal materials for conditioning fire hyperactivity due to kidney yin deficiency: 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 15 g of rhizoma anemarrhenae and 15 g of cortex phellodendri.

(17) Others are the same as in Example 4.

Example 6 (Fire Hyperactivity Due to Kidney Yin Deficiency)

(18) Preparation of traditional Chinese medicinal materials for conditioning fire hyperactivity due to kidney yin deficiency: 15 g of radix rehmanniae, 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 15 g of rhizoma anemarrhenae and 15 g of cortex phellodendri.

(19) Others are the same as in Example 4.

Example 7 (Kidney Yang Deficiency)

(20) Preparation of therapeutic traditional Chinese medicinal materials for prostatitis: 18 g of leech, 25 g of lumbricus, 23 g of eupolyphaga, 27 g of fructus foeniculi, 32 g of concha ostreae, 14 g of pangolin scales, 31 g of carapax trionycis, 22 g of radix achyranthis bidentatae, 34 g of rhizoma sparganii, 29 g of rhizoma curcumae, 23 g of radix notoginseng, 30 g of litchi chinensis sonn, 35 g of caulis spatholobi, 30 g of chinese honeylocust spine, 30 g of dandelion, 19 g of myrrh, 21 g of frankincense, 24 g of acacia catechu, 31 g of semen plantaginis, 30 g of hedyotis diffusa, 30 g of tangerine seed, 30 g of cyrtomium fortunei, 25 g of rhizoma chuanxiong, and 25 g of prunella vulgaris.

(21) Preparation of traditional Chinese medicinal materials for conditioning kidney yang deficiency: 15 g of radix rehmanniae, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of rhizoma polygonati, 10 g of morindae officinalis, 10 g of herba epimedii, 10 g of cortex cinnamomi and 10 g of radix paeoniae alba.

(22) Others are the same as in Example 1.

Example 8 (Kidney Yang Deficiency)

(23) Preparation of traditional Chinese medicinal materials for conditioning kidney yang deficiency: 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of rhizoma polygonati, 10 g of morindae officinalis, 10 g of herba epimedii, 10 g of cortex cinnamomi and 10 g of radix paeoniae alba.

(24) Others are the same as in Example 7.

Example 9 (Kidney Yang Deficiency)

(25) Preparation of traditional Chinese medicinal materials for conditioning kidney yang deficiency: 15 g of radix rehmanniae, 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of rhizoma polygonati, 10 g of morindae officinalis, 10 g of herba epimedii, 10 g of cortex cinnamomi and 10 g of radix paeoniae alba.

(26) Others are the same as in Example 7.

(27) The composition of combined external medicine for treating prostatitis prepared in the above Examples was applied as follows.

(28) A total of 900 patients suffering from prostatitis were selected and averagely divided into 9 groups, and each group has 100 people. In each group, there were an elderly group having 50 people (over 65 years old) and an adult group having 50 people (16-65 years old). The prevalence rate of children was extremely low, so no children were selected.

(29) The combined external medicine prepared in each Example was applied to skin. Before applying the medicine, an application part was washed with clear water. After air-drying, the pre-immune composition was respectively applied to skin of the lesion part and skin of left and right ribs. 5-10 minutes later, the lesion active composition and the double rib active composition were respectively applied to the skin of the lesion part and the skin of the left and right ribs. Airing for 10-40 minutes is needed after the application, and the medicine was applied twice a day, once in the morning and once in the evening. The lesion part is the skin of perineum, testis and the like. The medicine was applied for 10 days.

(30) Treatment results were shown in Table 1.

(31) TABLE-US-00001 TABLE 1 Treatment results of combined external medicine for treating prostatitis provided by Examples 1-9 of the present invention Elderly group (50 people) Adult group (50 people) Cured Effective Ineffective Effective Ineffective (number (number (number Cure Cured (number (number Cure of of of rate (number of of rate people) people) people) (%) of people) people) people) (%) Example Kidney yin 44 6 0 88 43 7 0 86 1 deficiency Example Kidney yin 45 5 0 90 44 6 0 88 2 deficiency Example Kidney yin 44 6 0 88 45 5 0 90 3 deficiency Example Fire 43 7 0 86 44 6 0 88 4 hyperactivity due to kidney yin deficiency Example Fire 45 5 0 90 43 7 0 86 5 hyperactivity due to kidney yin deficiency Example Fire 43 7 0 86 44 6 0 88 6 hyperactivity due to kidney yin deficiency Example Kidney yang 45 5 0 90 45 5 0 90 7 deficiency Example Kidney yang 44 6 0 88 43 7 0 86 8 deficiency Example Kidney yang 45 5 0 90 44 6 0 88 9 deficiency

(32) In the second Embodiment (Examples 10-18) in the international application (PCT/CN2016/083266) was taken as a Control Example, the treatment results of the second Embodiment (Examples 10-18) in the international application (PCT/CN2016/083266) were shown in Table 2, and the treatment period was 2 weeks, wherein Examples 10-18 in the second Embodiment were sequentially and correspondingly taken as Control Examples 1-9, i.e., the control example 1 was the original Example 10, and so on.

(33) TABLE-US-00002 TABLE 2 Treatment results of the combined external medicine for treating prostatitis provided by Control Examples Elderly group (50 people) Adult group (50 people) Cured Effective Ineffective Cure Cured Effective Ineffective Cure (number (number (number rate (number (number (number rate of people) of people) of people) (%) of people) of people) of people) (%) Control Kidney yin 30 20 0 60 41 90 0 82 example deficiency 1 Control Kidney yin 32 17 1 64 40 10 0 80 example deficiency 2 Control Kidney yin 34 15 1 68 38 10 2 76 example deficiency 3 Control Fire 35 15 0 70 40 9 1 80 example hyperactivity 4 due to kidney yin deficiency Control Fire example hyperactivity 36 12 2 72 40 10 0 80 5 due to kidney yin deficiency Control Fire example hyperactivity 35 14 1 70 41 9 0 82 6 due to kidney yin deficiency Control Kidney yang 32 17 1 64 39 11 0 78 example deficiency 7 Control Kidney yang 35 15 0 70 38 11 1 78 example deficiency 8 Control Kidney yang 34 16 0 68 37 12 1 74 example deficiency 9

(34) As can be seen from the comparison between Table 1 and Table 2, the combined external medicine for treating prostatitis provided by the present invention has a short treatment period and an improved cure rate, and the cure rate can reach 86% or more within 10 days.

(35) II. Combined External Medicine for Treating Prostatic Hyperplasia and Hypertrophy

Example 10 (Kidney Yin Deficiency)

(36) 1. Preparation of combined external medicine

(37) 1) Preparation of traditional Chinese medicinal materials

(38) Preparation of 100 g of noble bottle tree;

(39) Preparation of therapeutic traditional Chinese medicinal materials for prostatic hyperplasia and hypertrophy: 10 g of cortex phellodendri, 10 g of rhizoma anemarrhenae, g of pangolin scales, 10 g of carapax trionycis, 10 g of concha ostreae, 10 g of radix achyranthis bidentatae, 20 g of lysimachia christinae hance, 10 g of fructus crataegi, 10 g of rhizoma curcumae, 10 g of semen plantaginis, 10 g of caulis spatholobi, 20 g of herba leonuri, 10 g of rheum officinale, 10 g of chinese honeylocust spine, 10 g of acacia catechu, 10 g of leech, 10 g of lumbricus, 10 g of eupolyphaga, 15 g of largehead atractylodes rhizome, 10 g of rhizoma chuanxiong and 10 g of prunella vulgaris.

(40) Preparation of traditional Chinese medicinal materials for conditioning kidney yin deficiency: 15 g of radix rehmanniae, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of cuscuta chinensis lam, 10 g of semen astragali complanati and 10 g of rhizoma polygonati.

(41) 2) The above three kinds of medicinal materials were respectively decocted for 40-50 minutes into decoctions, and then concentrated over a high heat to a suitable amount, and cooled to 0 C. to 30 C. to obtain a noble bottle tree decoction, a first medical decoction for treating prostatic hyperplasia and hypertrophy, and a second medical decoction for conditioning liver and kidney;

(42) 3) the noble bottle tree decoction, the first medical decoction for treating prostatic hyperplasia and hypertrophy, and the second medical decoction for conditioning liver and kidney were respectively mixed with multi-immune powder according to a weight ratio of 38:62 to obtain a pre-immune composition, a lesion active composition, and a double rib active composition.

Example 11 (Kidney Yin Deficiency)

(43) Preparation of traditional Chinese medicinal materials for conditioning kidney yin deficiency: 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of cuscuta chinensis lam, 10 g of semen astragali complanati and 10 g of rhizoma polygonati.

(44) Others are the same as in Example 10.

Example 12 (Kidney Yin Deficiency)

(45) Preparation of traditional Chinese medicinal materials for conditioning kidney yin deficiency: 15 g of radix rehmanniae, 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of cuscuta chinensis lam, 10 g of semen astragali complanati and 10 g of rhizoma polygonati.

(46) Others are the same as in Example 10.

Example 13 (Fire Hyperactivity Due to Kidney Yin Deficiency)

(47) Preparation of therapeutic traditional Chinese medicinal materials for prostatic hyperplasia and hypertrophy: 30 g of cortex phellodendri, 30 g of rhizoma anemarrhenae, 15 g of pangolin scales, 20 g of carapax trionycis, 30 g of concha ostreae, 30 g of radix achyranthis bidentatae, 50 g of lysimachia christinae hance, 30 g of fructus crataegi, 30 g of rhizoma curcumae, 30 g of semen plantaginis, 40 g of caulis spatholobi, 40 g of herba leonuri, 30 g of rheum officinale, 30 g of chinese honeylocust spine, 30 g of acacia catechu, 30 g of leech, 30 g of lumbricus, 30 g of eupolyphaga, 50 g of largehead atractylodes rhizome, 30 g of rhizoma chuanxiong and 30 g of prunella vulgaris.

(48) Preparation of traditional Chinese medicinal materials for conditioning fire hyperactivity due to kidney yin deficiency: 15 g of radix rehmanniae, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 15 g of rhizoma anemarrhenae and 15 g of cortex phellodendri.

(49) Others are the same as in Example 1.

Example 14 (Fire Hyperactivity Due to Kidney Yin Deficiency)

(50) Preparation of traditional Chinese medicinal materials for conditioning fire hyperactivity due to kidney yin deficiency: 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 15 g of rhizoma anemarrhenae and 15 g of cortex phellodendri.

(51) Others are the same as in Example 13.

Example 15 (Fire Hyperactivity Due to Kidney Yin Deficiency)

(52) Preparation of traditional Chinese medicinal materials for conditioning fire hyperactivity due to kidney yin deficiency: 15 g of radix rehmanniae, 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 15 g of rhizoma anemarrhenae and 15 g of cortex phellodendri.

(53) Others are the same as in Example 13.

Example 16 (Kidney Yang Deficiency)

(54) Preparation of traditional Chinese medicinal materials for treating prostatic hyperplasia and hypertrophy: 14 g of cortex phellodendri, 19 g of rhizoma anemarrhenae, 5-15 g of pangolin scales, 15 g of carapax trionycis, 21 g of concha ostreae, 21 g of radix achyranthis bidentatae, 36 g of lysimachia christinae hance, 19 g of fructus crataegi, 20 g of rhizoma curcumae, 20 g of semen plantaginis, 27 g of caulis spatholobi, 31 g of herba leonuri, 22 g of rheum officinale, 16 g of chinese honeylocust spine, 17 g of acacia catechu, 15 g of leech, 18 g of lumbricus, 18 g of eupolyphaga, 35 g of largehead atractylodes rhizome, 20 g of rhizoma chuanxiong and 20 g of prunella vulgaris.

(55) Preparation of therapeutic traditional Chinese medicinal materials for conditioning kidney yang deficiency: 15 g of radix rehmanniae, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of rhizoma polygonati, 10 g of morindae officinalis, 10 g of herba epimedii, 10 g of cortex cinnamomi and 10 g of radix paeoniae alba.

(56) Others are the same as in Example 1.

Example 17 (Kidney Yang Deficiency)

(57) Preparation of traditional Chinese medicinal materials for conditioning kidney yang deficiency: 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of rhizoma polygonati, 10 g of morindae officinalis, 10 g of herba epimedii, 10 g of cortex cinnamomi and 10 g of radix paeoniae alba.

(58) Others are the same as in Example 16.

Example 18 (Kidney Yang Deficiency)

(59) Preparation of traditional Chinese medicinal materials for conditioning kidney yang deficiency: 15 g of radix rehmanniae, 15 g of rehmanniae vaporata, 10 g of fructus corni, 15 g of rhizoma dioscoreae, 6 g of cortex moutan, 6 g of poria cocos, 6 g of rhizoma alismatis, 10 g of rhizoma polygonati, 10 g of morindae officinalis, 10 g of herba epimedii, 10 g of cortex cinnamomi and 10 g of radix paeoniae alba.

(60) Others are the same as in Example 16.

(61) The combined external medicine for treating prostatic hyperplasia and hypertrophy prepared in the above Examples 10-18 was applied as follows.

(62) A total of 900 patients suffering from prostatic hyperplasia were selected and averagely divided into 9 groups, each group having 100 people. In each group, there were an elderly group having 50 people (over 65 years old) and an adult group having 50 people (16-65 years old). The prevalence rate of children was extremely low, so no children were selected.

(63) The combined external medicine prepared in each examples was applied to skin. Before applying the medicine, the application part was washed with clear water. After air-drying, a pre-immune composition was respectively applied to the skin of a lesion part and the skin of left and right ribs. 5-10 minutes later, a lesion active composition and a double rib active composition were respectively applied to the skin of the lesion part and the skin of the left and right ribs. Airing for 10-40 minutes is needed after application, and the medicine was applied twice a day, once in the morning and once in the evening. The lesion part was skin of perineum, testis and the like. The medicine was applied for 10 days.

(64) Treatment results were shown in Table 3.

(65) TABLE-US-00003 TABLE 3 Treatment results of combined external medicine for treating prostatic hyperplasia and hypertrophy provided by Examples 9-18 of the present invention. Elderly group (50 people) Adult group (50 people) Cured Effective Ineffective Cure Cured Effective Ineffective Cure (number (number (number rate (number (number (number rate of people) of people) of people) (%) of people) of people) of people) (%) Example Kidney yin 43 7 0 86 45 5 0 90 10 deficiency Example Kidney yin 43 7 0 86 43 7 0 86 11 deficiency Example Kidney yin 45 5 0 90 44 6 0 88 12 deficiency Example Fire 43 7 0 86 45 5 0 90 13 hyperactivity due to kidney yin deficiency Example Fire 45 5 0 90 44 6 0 88 14 hyperactivity due to kidney yin deficiency Example Fire excess due 44 6 0 88 43 5 0 90 15 to kidney yin deficiency Example Kidney yang 43 7 0 86 43 5 0 90 16 deficiency Example Kidney yang 44 6 0 88 45 5 0 90 17 deficiency Example Kidney yang 43 7 0 86 44 6 0 88 18 deficiency

Control Examples

(66) The pre-immune composition was not applied to the skin of the lesion site and the skin of left and right ribs, that is, the combined external medicine contains only the lesion active composition and the double rib active composition; the Examples 10-18 without the pre-immune composition were respectively and correspondingly taken as Control Examples 10-18. Others are the same as in Examples 10-18.

(67) Application of the combined external medicine for treating prostatic hyperplasia prepared in the above Examples 10-18

(68) A total of 900 patients suffering from prostatic hyperplasia were selected and divided into 9 groups, each group having 100 people. In each group, there were an elderly group having 50 people (over 65 years old) and an adult group having 50 people (16-65 years old). The prevalence rate of children was extremely low, so no children were selected.

(69) The combined external medicine prepared in Control Examples 9-18 was applied to the skin. Before applying the medicine, the application site was washed with clear water. After air-drying, the lesion active composition and the double rib active composition were respectively applied to the skin of the lesion site and the skin of left and right ribs. It should be aired for 10-40 minutes after application, and the medicine was applied twice a day, once in the morning and once in the evening. The lesion was located at the skin of the perineum, testis and the like. The medicine was applied for two weeks.

(70) The treatment results were shown in Table 4.

(71) TABLE-US-00004 TABLE 4 Treatment results of combined external medicine for treating prostatic hyperplasia provided by Control Examples 10-18 (not containing the pre-immune composition) Elderly group (50 people) Adult group (50 people) Cure Effective Ineffective Cure Cure Effective Ineffective Cure (number of (number (number rate (number (number (number rate people) of people) of people) (%) of people) of people) of people) (%) Control Kidney yin 27 22 1 54 33 15 2 66 example deficiency 10 Control Kidney yin 31 18 1 62 35 15 0 70 example deficiency 11 Control Kidney yin 33 16 1 66 36 13 1 72 example deficiency 12 Control Fire 34 14 2 68 30 20 0 60 example hyperactivity 13 due to kidney yin deficiency Control Fire 37 12 1 74 28 20 2 56 example hyperactivity 14 due to kidney yin deficiency Control Fire 35 14 1 70 38 12 0 76 example hyperactivity 15 due to kidney yin deficiency Control Kidney yang 33 17 0 66 34 15 1 68 example deficiency 16 Control Kidney yang 34 15 1 68 37 13 0 74 example deficiency 17 Control Kidney yang 30 19 1 60 28 21 1 56 example deficiency 9

(72) As can be seen from Table 4, when the pre-immune composition was not contained, that is, before applying the medicine, the pre-immune composition was not applied to the corresponding sites, the corresponding sites were scrubbed only with clear water, and other prescriptions remained the same, the cure rate was still low under the condition that the treatment time was extended for two times (the treatment time in Table 3 was 10 days, and the treatment time in Table 4 was 2 weeks and 14 days). As can be seen from Table 3, the combined external medicine for treating prostatic hyperplasia provided by the present invention has a short treatment period and an improved cure rate, and the cure rate can reach 86% or more within 10 days.