COMPOSITION FOR POLYAMINE BIOSYNTHESIS

Abstract

The invention relates to a composition comprising at least one C4 component and at least one C3 component, wherein the C4 component consists of ornithine and/or arginine or a suitable derivative of ornithine and/or arginine, wherein the C3 component consists of methionine and/or S-adenosylmethionine or a suitable derivative of methionine and/or S-adenosylmethionine, and wherein the molar ratio between the C3 component and the C4 component is between 1:5 and 5:1. The invention further relates to a nutritional supplement.

Claims

1-15. (canceled)

16. A composition comprising: at least one C4 component consisting of ornithine and/or arginine or a suitable derivative of ornithine and/or arginine; and and at least one C3 component consisting of methionine and/or S-adenosylmethionine or a suitable derivative of methionine and/or S-adenosylmethionine; wherein a molar ratio between the least one C3 component and the least one C4 component is between 1:5 and 5:1.

17. The composition according to claim 16, wherein: the molar ratio between the at least one C3 component and the at least one C4 component is from 0.8 to 1.2 parts of the C4 component and from 0.8 to 2.4 parts of the C3 component.

18. The composition according to claim 16, wherein: the at least one C4 component and the least one C3 component form an amino acid component.

19. The composition according to claim 18, wherein: the amino acid component is between 80 weight percent and 90 weight percent relative to total weight of the composition.

20. The composition according to claim 18, wherein: the amino acid component is between 85 weight percent and 95 weight percent relative to total weight of the composition.

21. The composition according to claim 18, wherein: the composition does not contain any further amino acid component in addition to the amino acid component formed from the at least one C4 component and the at least one C3 component.

22. The composition according to claim 18, wherein: the composition contains at least one further amino acid component in addition to the amino acid component formed from the at least one C4 component and the at least one C3 component, wherein the at least one further amino acid component is at most 5 weight percent relative to total weight of the composition.

23. The composition according to claim 22, wherein: the at least one further amino acid component is at most 2 weight percent relative to total weight of the composition.

24. The composition according to claim 16, further comprising: vitamin B, wherein the vitamin B is selected from at least one of the following: Vitamin B6, vitamin B12, and folic acid.

25. The composition according to claim 24, wherein: the vitamin B is between 0.05 weight percent and 0.5 weight percent relative to total weight of the composition.

26. The composition according to claim 24, wherein: the vitamin B is between 0.05 weight percent and 0.2 weight percent relative to total weight of the composition.

27. The composition according to claim 16, further comprising: a trace metal.

28. The composition according to claim 27, wherein: the trace metal comprises zinc.

29. The composition according to claim 27, wherein: the trace metal is between 0.05 weight percent and 0.2 weight percent relative to total weight of the composition.

30. The composition according to claim 16, for use in cell activation and/or induction of autophagy.

31. A nutritional supplement comprising or consisting of a composition according to claim 16.

32. The nutritional supplement according to claim 31, wherein: the nutritional supplement comprises glucose, wherein the glucose is between 70 weight percent and 95 weight percent relative to total weight of the composition.

33. The nutritional supplement according to claim 32, further comprising: a transport mediator.

34. The nutritional supplement according to claim 33, wherein: the transport mediator comprises an agent activating glucose transporter GLUT1.

35. The nutritional supplement according to claim 33, wherein: the transport mediator is between 0.5 weight percent and 10 weight percent relative to the total weight of glucose in the composition.

36. The nutritional supplement according to claim 33, wherein: the transport mediator is selected from at least one of the following: phytopreparation, oestrogen-like natural substance, omega-3 fatty acid, and biguanide.

Description

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

Example Group 1 With L-Methionine and L-Ornithine as Precursors

Example 1a: Component Mixture

[0048] A base mixture of 110 mg L-methionine (about 65%) and 60 mg ornithine (about 35%) with 0.53 mg zinc bisglycinate and 0.28 mg vitamin B6 is prepared by mixing. The composition may be used in particular as an additive to medicinal products or as a premix for a nutritional supplement with other ingredients.

Example 1b: Dextrose Drops

[0049] A component mixture according to example 1a is compressed with 2.44 g of dextrose with the addition of citric acid and flavourings of the types tropic, passion fruit and elderberry flower, using magnesium salts of fatty acids and hydrogenated vegetable oils as excipients, to form a tablet with a weight of 2.7 g.

[0050] Dextrose drops according to example 1b are, apart from the uses indicated in the description, particularly well suited as a means of remedying hypoglycaemic episodes in patients with type 1 diabetes (instead of conventional dextrose drops).

Example 1c: Dextrose Drops With Activator

[0051] A tablet according to example 1b is compressed with an addition of 15 mg resveratrol. Dextrose drops according to example 1c are particularly suitable for supplying the brain with nutrients and thus for maintaining a normal brain metabolism.

Example 1d: Sugar Sticks With Glucose

[0052] A powdered component mixture according to example 1a is mixed with 15 mg trans-resveratrol and 1.85 g dextrose and adjusted to a sweetening value corresponding to that of 4 g sucrose by adding small amounts of sweetener. The sweeteners used may be any authorised sweeteners, preferably 37.5 mg of a sodium cyclamate-sodium saccharin 10:1 mixture.

[0053] The nutritional supplement of example 1d may be used as a sweetener for tea, coffee and other beverages and is present in the form of pre-portioned sweetener sticks. In addition to the uses given in example 1d, it is suitable as a calorie-reduced sweetener for the treatment of obesity.

Example 1e: Melissa Ginseng Instant Drink With Activator

[0054] To a component mixture according to example 1a, 15 mg of trans-resveratrol, 200 mg of melissa extract, 20 mg of ginseng extract, and 20 mg of peppermint extract are added. 4.4 g of dextrose and 76 mg of a sodium cyclamate-sodium saccharin 10:1 mixture are added and the mixture is packed into a can.

Example 1f: Hop Ginseng Instant Drink With Activator

[0055] The preparation is analogous to that of example 1e. Instead of the melissa extract, 70 mg of hop extract (65-70% content), as well as 40 mg of orange flavouring and 2.5 mg of lemon flavouring are used.

[0056] The instant mixtures according to example 1e and 1f are dissolved in a beverage, preferably in an amount of 125 ml for a 5 g portion and preferably in water.

[0057] Instant blends with other flavour components may be produced analogously to examples 1e and 1f. The instant mixtures according to examples 1e and 1f are suitable, apart from the uses indicated in the description, as agents for reducing blood glucose levels in patients with prediabetes or type 2 diabetes. For this purpose, the instant mixtures may be sweetened with another sugar, a sugar substitute or sweetener as an alternative to dextrose, or they may be used unsweetened.

Example Group 2 With S-Adenosylmethionine and L-Ornithine as Precursors

Example 2a: Component Mixture

[0058] A base mixture of 160 mg S-adenosymethionine, 60 mg L-methionine and 60 mg ornithine with 0.28 mg vitamin B6 is prepared by mixing. The composition may be used in particular as an additive to medicinal products or as a premix for a nutritional supplement with other ingredients.

[0059] The composition may be used in particular as an additive to medicinal products or as a premix for a nutritional supplement with other ingredients.

Example 2b: Dextrose Drops

[0060] A component mixture according to example 2a is compressed with 2.44 g of dextrose with the addition of citric acid and flavourings of the types tropic, passion fruit and elderberry flower, using magnesium salts of fatty acids and hydrogenated vegetable oils as excipients, to form a tablet with a weight of 2.7 g.

[0061] Dextrose drops according to examples 2a and 2b may also be produced with other flavours. They are, apart from the uses indicated in the description, particularly well suited as a means of remedying hypoglycaemic episodes in patients with type 1 diabetes (instead of conventional dextrose drops).

Example 2c: Tablets With an Antidiabetic

[0062] A component mixture according to example 2a is compressed with 0.6 g of the antidiabetic drug metformin, 1.85 g of dextrose and 37.5 mg of a sodium cyclamate-sodium saccharin 10:1 mixture with the addition of citric acid and flavourings of the types tropic, passion fruit and elderberry blossom and using magnesium salts of fatty acids and hydrogenated vegetable oils as excipients to form a tablet with a weight of 2.7 g.

[0063] Tablets according to example 2c may be used to treat type 2 diabetes and to prevent neurodegeneration.

Example 2d: Sugar Sticks With Glucose

[0064] A powdered component mixture according to example 2a is mixed with 15 mg trans-resveratrol and 1.85 g dextrose and by adding small amounts of sweeteners, any permitted sweeteners, preferably 37.5 mg of a sodium cyclamate-sodium saccharin 10:1 mixture may be used.

[0065] The nutritional supplement of example 2d may be used as a sweetener for tea, coffee and other beverages and is in the form of pre-portioned sweetener sticks. In addition to the uses given in example 1c, it is suitable as a calorie-reduced sweetener for the treatment of obesity.

Example 2e: Flavoured Sugar Sticks With Glucose

[0066] Apple flavouring is added to a powdered component mixture according to example 2c.

[0067] The nutritional supplement of example 2e may preferably be used in 125 ml of water or soda water as a soft drink. As the product in example 2c, it is also suitable as a calorie-reduced sweetener for the treatment of obesity.

Example 2f: Melissa Ginseng Instant Drink With Activator

[0068] To a component mixture according to example 2a, 15 mg of trans-resveratrol, 200 mg of melissa extract, 20 mg of ginseng extract and 20 mg of peppermint extract are added. 4.4 g of dextrose and 76 mg of a sodium cyclamate-sodium saccharin 10:1 mixture are added and the mixture is packed into a can.

Example 2g: Coffee Ginseng Instant Drink With Activator

[0069] To a component mixture according to example 2a, 15 mg of trans-resveratrol and blonde roast coffee extract are added. 4.4 g of dextrose and 76 mg of a sodium cyclamate-sodium saccharin 10:1 mixture are added and the mixture is packed into a can. Instant blends with other flavour components may be produced analogously.

[0070] The instant mixtures according to examples 2f and 2 g are suitable, apart from the uses indicated in the description, as agents for reducing blood glucose levels in patients with prediabetes or type 2 diabetes. For this purpose, the instant mixtures may be sweetened with another sugar, a sugar substitute or sweetener as an alternative to dextrose, or they may be used unsweetened.

Example Group 3: Arginine in Dual Function as Precursor and Endothelium-Relaxing Component

[0071] In this product group, arginine has a dual function both as an endothelium-relaxing agent (NO donor) and as a spermidine precursor (after decarboxylation via the pathway of agmatine with subsequent urea splitting to ornithine and to spermidine, respectively).

Example 3a: Component Mixture

[0072] A base mixture of 140 mg L- methionine, 200 mg L-arginine hydrochloride and 0.28 mg vitamin B6 is prepared by mixing. The composition may be used in particular as an additive to medicinal products or as a premix for a nutritional supplement with other ingredients.

Example 3b: Dextrose Drops

[0073] A component mixture according to example 3a is compressed with 40 micrograms of folic acid, 0.5 micrograms of vitamin B12 and 2.3 g of dextrose with the addition of citric acid and flavourings of the types tropic, passion fruit and elderberry flower, using magnesium salts of fatty acids and hydrogenated vegetable oils as excipients, to form a tablet with a weight of 2.7 g.

[0074] Dextrose drops according to example 3b may also be produced with other flavours. They have an effect against apoptotic processes. They are, apart from the uses indicated in the description, particularly well suited as a means of remedying hypoglycaemic episodes in patients with type 1 diabetes (instead of conventional dextrose drops).

Example 3c: Sugar Sticks With Glucose

[0075] A powdered component mixture according to Example 3a is added with 40 micrograms of folic acid, 0.5 microgram of vitamin B12 and sweetened with 1.85 g of dextrose, and with 37.5 mg of a sodium cyclamate-sodium saccharin 10:1.

[0076] The nutritional supplement of example 2e may be used as a sweetener for tea, coffee and other beverages and is present in the form of pre-portioned sweetener sticks. In addition to the uses given in example 1c, it is effective against apoptotic processes and is suitable as a calorie-reduced sweetener for the treatment of obesity.

Example 3d: Hop Ginseng Instant Drink With Activator

[0077] A component mixture according to example 3a is mixed with 40 micrograms of folic acid, 0.5 micrograms of vitamin B12, 50 mg of hop extract (65-70% content), 20 mg of ginseng extract, 20 mg of peppermint extract, and 40 mg of orange flavouring and 2.5 mg of lemon flavouring. 4.4 g of dextrose and 76 mg of a sodium cyclamate-sodium saccharin 10:1 mixture are added and the mixture is packed into a can.

[0078] The instant mixtures according to example 3e are dissolved in a beverage, preferably in an amount of 125 ml for a 5 g portion and preferably in water.

[0079] Instant blends with other flavour components may be produced analogously. Instant mixtures according to example 3e have an anti-apoptotic effect. They are suitable, apart from the uses indicated in the description, as agents for reducing blood glucose levels in patients with prediabetes or type 2 diabetes. For this purpose, the instant mixtures may be sweetened with another sugar, a sugar substitute or sweetener as an alternative to dextrose, or they may be used unsweetened.

[0080] The component mixtures of examples 1a, 2a and 3a are compositions according to the present invention and as such may be used as nutritional supplements without further additives. The above component mixtures achieve the effects according to the present invention.

[0081] The remaining examples are nutritional supplements within the meaning of the present invention, wherein further ingredients are contained, for example glucose, sweeteners and a transport mediator.