METHOD OF SYNERGETIC MINIMIZATION OF NEGATIVE IMPACT CAUSED BY FLIGHTS ON HUMAN HEALTH

Abstract

This invention is referred to the field of medicine, namely preventative treatment, and may be used as a means of synergetic minimization of negative impact of flights on human health (brain, stomach, lungs, blood vessels, heart etc.) with application of known substances and medicines with newly discovered pharmacological properties in new conditions. The ultimate technical solution of this invention would be synergetic minimization of negative impact of flying on human health without foot swelling, belching, jet-lag, tiredness and fatigue etc. The claimed technical result is achieved by the method of synergetic minimization of negative impact of air flights on human health, including consumption of substances that improve osmotic concentration of blood plasma, in the form of oral rehydration solution, split into two intakes as a minimum, first intake in the amount of at least 0.3 liters up to 1 liter before boarding and further during the flight from half an hour to 2 hours at least 0.3 liters to 1 liter and on as-needed basis.

Claims

1. A kit for reducing the negative impact of air travel on a human subject by administering blood plasma osmolarity increasing preparations to the human subject, the kit comprising: at least two doses of an aqueous solution for oral rehydration solution containing sodium chloride, potassium chloride, sodium citrate, glucose, and an anticoagulant, the first dose calculated for an amount of not less than 0.3 liters to 1 liter and a second dose calculated for the amount of not less than 0.3 liters to 1 liter.

2. The kit of claim 1, wherein the anticoagulant is effervescent acetylsalicyclic acid.

3. The kit of claim 1, wherein the anticoagulant is acetylsalicyclic acid.

4. The kit of claim 1, wherein the anticoagulant is warfarin.

5. The kit of claim 1, wherein the anticoagulant is heparin.

6. The kit of claim 1, wherein the oral rehydration solution is one dose or one sachet of 18.9 g of powder containing 3.5 g sodium chloride, 2.5 g potassium chloride, 2.9 g sodium citrate, and 10 g glucose in the following ratio of components: 18.5% sodium chloride, 13.2% potassium chloride, 15.3% sodium citrate, and 52.9% glucose when dissolved in 1 liter of boiled water.

7. The kit of claim 1, wherein the kit is used to treat in a subject in need thereof small intestine bacterial overgrowth syndrome (SIBOS) by administering a therapeutically effective amount of (i) one or more probiotics or (ii) simethicone or simethicone and alvarine citrate or simethicone and dimethicone or (iii) a prokinetic medication.

8. The kit of claim 7, wherein the prokinetic medication is domperidone.

9. The kit of claim 1, wherein the anticoagulant is Rivaroxaban.

10. The kit of claim 1, wherein the kit is used to treat dehydration and restore blood plasma osmolarity due to airline travel in a subject in need thereof.

11. The kit of claim 10, wherein the first dose is administered to the subject before boarding an airplane, and the second dose administered to the subject in the airplane in the time interval of after half an hour and up to 2 hours after boarding the airplane.

12. The kit of claim 10, wherein the first dose is administered 20-30 minutes before boarding an airplane.

Description

DETAILED DESCRIPTION OF INVENTION

[0041] This invention is a way of synergetic minimization of negative impact of air flights on human health, including consumption of substances that improve osmotic concentration of blood plasma, in the form of oral rehydration solution, split into two intakes as a minimum, first intake in the amount of at least 0.3 liters up to 1 liter before boarding and further during the flight from half an hour to 2 hours at least 0.3 liters to 1 liter and on as-needed basis.

[0042] Oral rehydration solution, 1 sachet of REHYDRON® powder—18.9 g, containing sodium chloride—3.5 g, potassium chloride—2.5 g, sodium citrate—2.9 g and glucose—10 g with the following ratio: sodium chloride—18.5%, potassium chloride—13.2%, sodium citrate—15.3%, glucose—52.9% per 1 liter of water is used in one of scenarios of synergetic minimization of negative impact on flights on human body.

[0043] HYDROVIT® or MARATONIC® may also be used as oral rehydration solution instead of REHIDRON®.

[0044] One of additional measures for synergetic minimization of negative impact of flights on human body is a single dose of anticoagulant 20-30 minutes before the flight. Dissolvable ASPIRIN®, CARDIOMAGNYL®, WARFARIN® or HEPARIN® may be used as an anticoagulant.

[0045] One of additional measures for synergetic minimization of negative impact of flights on human body is prevention of small bowel bacterial overgrowth syndrome. To this end: [0046] Bifidumbacteria probiotics are taken before boarding; [0047] foam preventative substances with active simethicone component are taken in the amount of 4 capsules before boarding and another 4 capsules after the meal during the flight (1 capsule 40 mg each). ESPUMISAN® or ANTIFLAT®, SAB SIMPLEX® or SIMICOL® are used as foam preventative substances. [0048] prokinetics with active domperidone component—2 pills before the flight and another 2 pills after the meal during the flight, 10 mg each, MOTILIUM®, DOMSTAL®, MOTORIKUM®, PERIDAL® or PERIDONE® or MOTILIUM® are used as prokinetics.

Case History

[0049] Case 1. Passenger Ilona L (31 years) experienced feet swelling, leg muscle cramps, fainting, had ear and stomach ache during Vienna-Moscow-Almaty flight. After the flight she had to be treated from small bowel bacterial overgrowth syndrome.

[0050] One month after during Almaty-Moscow-Vienna flight she took recommended substances in certain sequence and single doses: Rehydron solution in the amount of 0.5 l before boarding, and 0.5 l after 2 hours of flight, 1 pill of anticoagulant 20-30 minutes before the flight (1 dissolvable aspirin); 4 bottles of Bifidumbacterin probiotics before the flight, simethicone (ESPUMISAN®) 4 capsules before boarding and another 4 capsules after the meal during the flight (1 capsule 40 mg each), prokinetic with active ingredient domperidone (MOTILIUM®)—2 pills before the flight and another 2 pills after the meal during the flight, 10 mg each. The flight was easy, no feet swelling, no headache, ear ache was suppressed with a popsicle. She was feeling great after the flight.

[0051] Example 2. Passenger Yury B (71) experienced heart ache, leg pain, panic attack, had pain in the stomach and excessive sweating during Ust-Kamenogorsk-Moscow-San Francisco flight. He had heart stroke after landing and coronary artery stent placed in the US clinic. Three months after before boarding San Francisco-Moscow flight he took medicines for synergetic minimization of negative impact of the flight on health: intramuscular Cytochrome injections before the flight; Rehydron solution in the amount of 0.5 l before the flight and 0.5 l 2 hours after the flight; took the following before boarding: 4 bottles of Bifidumbacterin probiotics, 4 capsules of simethicone, prokinetic with active substance domperidone—2 pills; the following after the meal during the flight: simethicone—4 capsules (1 capsule 40 mg each) and 2 capsules of domperidone, 10 mg each. The flight was successful. There was no jet lag or fatigue feeling, no bloating and other negative consequences during the flight. He later successfully travelled to the clinic in Almaty City using means for synergetic minimization.

[0052] Multiple studies of synergetic minimization of negative impact of the flight on human health demonstrate that intake of above-mentioned substances and medicines with new pharmacological value in new conditions prevent feet swelling, bloating, jet lag and fatigue during the flight.

[0053] As such, the above-mentioned medicines with new pharmacological value (improved osmotic concentration of blood, prevention of small bowel bacterial overgrowth syndrome, improved immune system response) in new conditions are recommended to passengers in order to minimize negative impact of flights on human health in the following order:

[0054] to increase osmotic concentration of blood—1 sachet of oral rehydration solution—REHIDRON®, HYDROVIT® or MARATONIK®; take 0.5 l before the flight and another 0.5 2 hours after); to improve blood flow and prevent excessive coagulation take anticoagulants during the flight—dissolvable ASPIRIN® 1 tablet (20-30 minutes before the flight) or CARDIOMAGNYL® or WARFARIN® or HEPARIN® (Note. If passenger is already taking these substances, he does not need to take them additionally).

[0055] To prevent small bowel bacterial overgrowth syndrome: [0056] take probiotics, several bottles—Bifidumbacteria or Lactobacteria (before boarding). [0057] take foam preventive substances with active ingredient—simethicone, for example, ESPUMISAN® or METEOSPASMYL® or ANTIFLAT® or SAB SIMPLEX® or SIMICOL®)—4 capsules (before boarding and another 4 capsules after the meal during the flight); [0058] take prokinetics with active ingredient domperidone (MOTILIUM®, DOMSTAL®, MOTORIKUM®, PERIDAL®, PERIDON®), MOTILIUM®—2 tablets (before the flight and another 2 tables after the meal during the flight).

[0059] This invention promotes means of synergetic minimization of negative impact of the flight on passenger health with application of known substances and medicines with new pharmacological value in new conditions and attributes to positive state of health of passengers during the flight.

[0060] All methods used for synergetic minimization of negative impact of the flight on passenger health are known active substances with new pharmacological value in new conditions and are sold off-counter.

[0061] This range of known active pharmaceutical substances with new pharmacological value, including oral fixed dose, may be obtained by means of selection of the above-mentioned substances in therapeutic effective quantities with the standard kit: [0062] oral rehydration substances; [0063] anticoagulants; [0064] probiotics; [0065] foam preventative substances with active ingredient—simethicone; [0066] prokinetics with active ingredient domperidone.
This means of synergetic minimization of negative impact of the flights with consecutive consumption of the above active substances was tested in over 50 overseas flights during the past five years. We also perform studies of over 100 patients arriving into our clinic from abroad. Many patients state that they experienced panic, sleepiness, muscle cramps, small bowel bacterial overgrowth syndrome during the flight. They also suffered from sinusitis and vessel disorders (heart attack, stents placed) after the flights.

[0067] After utilization of declared means and instruction there was no panic, stomach aches, sleepiness, memory loss and mental confusion during the flight. Good boom was observed. The results were evaluated based on the following factors: complaints from passengers with regard to flight impact before and after utilization.

[0068] The studies were performed after the flight and then during the month after arrival through survey and visual examination. The obtained positive results were consistent during 2 months after the flights.

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