Antiseptic wound dressing

Abstract

The antiseptic wound dressing includes at least nanometer chitin, alkaline earth metal alginate, and an antiseptic material. The nanometer chitin is tubular shaped having diameter 1050 nm and length 20200 nm. The amount of the nanometer chitin is 0.1%5% to the alkaline earth metal alginate. The antiseptic wound dressing is manufactured by mixing nanometer chitin and alkaline metal alginate, further mixing with antiseptic material, conducting a wet spinning process to produce fibers, and conducting a non-woven cloth process to obtain the antiseptic wound dressing of the present invention. Therefore, the antiseptic wound dressing is capable of reducing the chance of would infection, and providing superior moisture retention and enhanced wet strength.

Claims

1. An antiseptic wound dressing manufactured by a process comprising the steps of: providing a first solution where nanometer chitin is dispersed evenly in water and alkaline metal alginate powder is mixed in the water; providing a second solution by mixing an antiseptic material in the first solution; conducting a wet spinning process, where the second solution is filled into a grooving tank storing a grooving liquid which includes 5% calcium chloride solution, when the second solution contacts with the calcium chloride solution, the sodium ions in the alkaline metal alginate swap with calcium ions to form solid fibers of calcium alginate, and the fibers are then washed and dried; and conducting a non-woven cloth process comprising opening, combing, needle-bonding, calendering, and obtaining the antiseptic wound dressing of nanometer chitin calcium alginate; wherein the antiseptic wound dressing comprises nanometer chitin, alkaline earth metal alginate, and the antiseptic material; the nanometer chitin is tubular shaped having diameter 1050 nm and length 20200 nm; and the amount of nanometer chitin is 0.1%5% to the alkaline earth metal alginate.

2. The antiseptic wound dressing according to claim 1, wherein the antiseptic material comprises silver particles, Polyhexamethylene Biguanide (PHMB), or Chlorhexidine Gluconate (CHG).

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 is a flow diagram showing the steps of manufacturing an antiseptic wound dressing according to an embodiment of the present invention.

(2) FIG. 2 provides a diagram comparing the antiseptic effect and cytotoxicity of various wound dressings.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

(3) The following descriptions are exemplary embodiments only, and are not intended to limit the scope, applicability or configuration of the invention in any way. Rather, the following description provides a convenient illustration for implementing exemplary embodiments of the invention. Various changes to the described embodiments may be made in the function and arrangement of the elements described without departing from the scope of the invention as set forth in the appended claims.

(4) The present invention is an antiseptic wound dressing, comprising nanometer chitin, alkaline earth metal alginate, and antiseptic material. The nanometer chitin is tubular shaped having diameter 1050 nm and length 20200 nm. The amount of nanometer chitin is 0.1%5% to the alkaline earth metal alginate.

(5) In addition, the antiseptic material may include silver particles, Polyhexamethylene Biguanide (PHMB), or Chlorhexidine Gluconate (CHG).

(6) As shown in FIG. 1, the antiseptic wound dressing is manufactured as follows, where the antiseptic material is embodied using silver particles:

(7) Step A: providing a first solution where nanometer chitin is dispersed evenly in water and alkaline metal alginate powder is mixed in the water.

(8) Step B: providing a second solution by mixing silver particles in the first solution. The silver particles are added last to prevent nanometer chitin to react with the silver particles and cluster together, thereby losing its original size and function.

(9) Step C: conducting a wet spinning process, where the second solution is filled into a grooving tank storing a grooving liquid which includes 5% calcium chloride solution. When the second solution contacts with the calcium chloride solution, the sodium ions in the alkaline metal alginate swap with calcium ions to form solid fibers of calcium alginate. The fibers are then washed and dried.

(10) Step D: conducting a non-woven cloth process including opening, combing, needle-bonding, calendering, etc., and obtaining the antiseptic wound dressing of nanometer chitin calcium alginate.

(11) To test the effect of the nanometer chitin in moisture retention, three wound dressings are compared: one with 100% alkaline earth metal alginate without nanometer chitin (100% Alginate), one with alkaline earth metal alginate added 1% nanometer chitin relative to the alkaline earth metal alginate (Alginate+1% chitin), and one with alkaline earth metal alginate added 2% nanometer chitin relative to the alkaline earth metal alginate (Alginate+2% chitin). Their ability of moisture retention is recorded in the Table 1.

(12) The three wound dressings are cut into a same dimension and weighed. A fixed amount of saline solution is then added to and absorbed by the wound dressings. The wound dressings are placed in an oven whose temperature is maintained at 37 degrees Celsius. The three wound dressings are then weighed after 30, 60, 90, and 120 minutes. Their reduced weight is the amount of water lost.

(13) TABLE-US-00001 TABLE 1 100% Alginate + Alginate + Alginate 1% chitin 2% chitin Base weight (g) 0.23 0.215 0.24 Wet weight (g) 2.035 1.84 2.11 30 min Water 74% 74% 77% residual rate 60 min Water 64% 66% 70% residual rate 90 min Water 56% 59% 63% residual rate 120 min Water 46% 50% 56% residual rate

(14) As shown in Table 1, after 120 minutes, the Alginate+2% chitin wound dressing has 10% more remaining water than that of the 100% alginate wound dressing, suggesting that the former has superior water retention capability.

(15) Wound healing mainly relied on the degree of moisture between wound dressing and the wound. A wound dressing having greater moisture retention capability therefore provides faster healing to the wound. In addition, a wound dressing having greater moisture retention capability requires less frequent replacement. The nanometer chitin is able to attract more water molecules due to its surface area. As shown in Table 1, the wound dressing with nanometer chitin added is superior.

(16) To test the effect of the nanometer chitin in dressing wet strength, wound dressings of various amounts of nanometer chitin are cut into pieces of 2.54 by 7.5 cm, and tested by a universal tension machine. The result is shown in Table 2. As illustrated, wound dressings with nanometer chitin added all have superior wet strength than that of wound dressing without nanometer chitin. When wound dressing has low wet strength and it is removed from wound, portion of it may remain attach to the wound, thereby requiring additional cleaning. Therefore, wound dressing with stronger dressing wet strength is superior.

(17) TABLE-US-00002 TABLE 2 100% Alginate Alginate + 1% chitin Alginate + 2% chitin Average Average Average Tension Tension Tension Tension Tension Tension 1 9.785 8.2N 15.729 12.35N 13.5 11.74N 2 7.278 13.5 11.58 3 7.615 9.676 10.47 4 10.525 11.43

(18) To further test the present invention's antiseptic capability and effect on cytotoxicity, three wound dressings are compared. One wound dressing is from Coloplast, one is a conventional alkaline earth metal alginate dressing (Alginate), and one is the present invention's antiseptic wound dressing which is an alkaline earth metal alginate dressing with 1600 ppm silver (Ag) particles and 1% nanometer chitin added (relative to the alkaline earth metal alginate) added. The test result is shown in FIG. 2.

(19) The test procedure is conducted as follows:

(20) 1. Obtaining an extract by extracting a fixed percentage of a dressing.

(21) 2. Culturing the extract and L929 cells together for 24 hours.

(22) 3. Calculating cell survival ratio, where a higher cell survival ratio indicates that the dressing is less toxic.

(23) As shown in FIG. 2, the present invention's antiseptic wound dressing has superior antiseptic capability and low cytotoxicity. In contrast, Coloplast dressing has obvious antiseptic effect but also obvious cytotoxicity. The conventional alkaline earth metal alginate dressing (Alginate) has low cytotoxicity but inferior antiseptic effect.

(24) As described above, the antiseptic wound dressing according to the present invention, through adding nanometer chitin, reduces the chance of would infection. In addition, nanometer chitin's ability in attracting water molecules provides superior moisture retention and enhanced wet strength, thereby achieving faster healing and convenient wound treatment.

(25) While certain novel features of this invention have been shown and described and are pointed out in the annexed claim, it is not intended to be limited to the details above, since it will be understood that various omissions, modifications, substitutions and changes in the forms and details of the device illustrated and in its operation can be made by those skilled in the art without departing in any way from the claims of the present invention.