COMBINATION OF AN APPLICATOR AND OF A SUSPENSION HAVING AN ACTIVE PRINCIPLE

Abstract

The present invention relates to a combination of a flexible container of the type with a brush and a tube enclosing a homogeneous suspension composed of an aqueous phase and of an oily phase which has at least one active principle, characterized in that the container has an applicator consisting of friction members suitable for applying said suspension at the outlet of an orifice onto a zone of the body of a subject to be treated, said suspension having a suitable viscosity allowing it to be distributed homogeneously via said members of said applicator.

Claims

1. Combination of a container (1) with a flexible wall and a generally homogenous suspension (3) contained in said container (1), at least one orifice (6) being made in a point of said container (1) so as to achieve the evacuation of a controlled quantity of said suspension (3), said suspension (3) comprising a continuous aqueous phase that forms 80 to 99.5% of its weight, wherein said aqueous phase contains particulate solid supports, the amount sufficient to make up 100% consisting of an oily or lipophilic phase containing at least one active ingredient, the container (1) also comprising an applicator (2) consisting of friction members (5) made of a polymer material, suitable for applying said suspension (3) from the outlet of said orifice (6) onto an area of the body of the subject to be treated, said suspension (3) having an apparent suitable viscosity of between 1000 and 500000 centipoises, allowing it to be distributed homogeneously by said members (5) of said applicator (2), said organs being formed by a plurality of flexible teeth which, taken as a whole, forms a row, the cross-sectional view of which resembles that of a cone.

2. Combination The combination according to claim 1, wherein the suspension (3) is a gel or a cream.

3. Combination The combination according to claim 1, wherein applicator (2) is a brush, the flexible teeth of which are spaced apart by an average distance of between 0.1 mm and 7 mm.

4. Combination The combination according to claim 3, wherein the teeth are of a length of between 2 and 15 mm, and are sufficiently flexible to untangle the hairs, separate them and also smooth said suspension (3) over the hair.

5. (canceled)

6. Combination The combination according to claim 1, wherein the teeth of the applicator (2) are stiffened, spaced 4 to 5 mm apart and have a length of 3 to 5 mm.

7. Combination The combination according to claim 1, wherein the active ingredient induces a feeling of wellbeing and is chosen from essential oils, plant extracts, non-steroidal anti-inflammatory (NSAI) drugs, methyl salicylate and its derivatives and monoterpenic alcohols.

8. Combination The combination according to claim 1, wherein the active ingredient has an anti-pest action and is chosen from essential oils, pyrethrins, pyrethrinoids, carbamates, formamidines, icaridin, DEET, plant extracts and macerates such as margosa extract, repellent plant oils, nictotinyl compounds and monoterpenic alcohols such as geraniol, linalool, citriodiol or mixtures thereof.

9. The combination according to claim 1, wherein the suspension (3) comprises, in its aqueous phase, 0.1 to 30% of its weight of solid microparticles with an average grain size of between 1 m and 1 mm.

10. Combination The combination according to claim 9, wherein the microparticles contain the active ingredient(s) in an amount of between 0.5 and 35% by weight in relation to the total weight of the microparticles.

11. Combination The combination according to claim 1, wherein the microparticles of the suspension (3) are chosen from lamellar clays, kaolinites, porous silicas, zeolites, polymers of plant origin, polymers giving absorbent matrices and belonging to the polyethylene family, ethylene copolymers, polyamides, copolyam ides, polyurethanes, polymethyl sesquioxanes, polyvinyl chloride, polyesters, polylactic acid or mixtures thereof.

Description

[0045] The Single FIGURE shows a schematic cross-section, not to scale, of a reservoir-tube surmounted by a brush-applicator suitable for the distribution of the gel formulation defined in Tables 1 and 2.

[0046] This FIGURE shows a container in the form of a reservoir-tube (1) made of polyethylene, the walls of which are flexible. The body of the reservoir-tube (1) extends into a bottleneck (4) 35 mm in diameter, which is surmounted by a brush-applicator (2) in the center of which is arranged an outlet orifice (6) for the gel (3), an orifice that is 5 mm in diameter. The brush-applicator (2) consists of a plurality of teeth (5) arranged in 10 concentric circles of which the overall geometric form resembles the roof of a house. Within this row, the teeth round the peripheral edge have a length (L1) of 7 mm, while those located in the center have a length (L2) of 10 mm. The space between the teeth measures 1 mm.

[0047] From the constituents listed in Table 1, a homogenous suspension is obtained in the form of a gel, the viscosity of which is 368000 centipoises (with mobility of 64 at 20 C.) after manufacture. This gel is introduced into the reservoir-tube surmounted by a brush-applicator shown in FIG. 1. By squeezing the walls of the reservoir-tube, about a 2 g hazelnut-sized amount of gel is extruded; this is then applied onto the dog's abdomen by holding the reservoir-tube in a position forming an angle of 90 in relation to a horizontal plane, the brush-applicator being turned upwards. It will be noted that nothing leaks out during the application. Thanks to the brush-applicator, the dog's hairs are well separated for the application, which enables good adhesion of the gel mainly onto the skin of the ventral area.

[0048] From the constituents of Table 2, a gel is obtained with a viscosity of 90381 centipoises 3 days after manufacture. The anti-parasitic gel thus obtained is applied homogenously without leakage onto a dog's hairs, thanks to the brush-tube applicator described above.