One kind of Live Bacteria Preparation of Bacillus Coagulans and Preparation Method thereof

Abstract

One kind of live bacteria preparation of bacillus coagulans, the aforesaid live bacteria preparation is in the form of tablets; such live bacteria tablet is made from the bacteria powder of bacillus coagulans HQ-1, subsequently coated with gelatin and cooled, then made with other pharmaceutical auxiliary ingredients. The preparation method of such live bacteria preparation includes the following steps: preparing the pellet core coated with the bacteria powder; preparing the gelatin solution; wrapping the gelatin solution outside the pellet core, cooling to obtain the hard capsule; preparing the powder or pill with other pharmaceutical auxiliary ingredients and syrup; pressing to form the tablets. Such live bacteria tablet can fully protect the effective ingredient bacteria powder in the stomach and intestine, allowing the coat to be melt when reaching the affected area, so as to ensure a high utilization rate of bacteria powder.

Claims

1. The characteristics of the aforesaid live bacteria preparation of bacillus coagulans is its tablet form; this live bacterial tablet is made from the bacterial powder of bacillus coagulans HQ-1, which is coated with gelatin and cooled, and then made with other pharmaceutical auxiliary ingredients.

2. Aright-claim for the preparation method of such live bacteria preparation, characterized by the following steps: 1) Take sucrose and purified water for heating and dissolving, and then cool down to obtain the syrup, ready for follow-up use; 2) Under room temperature, put the starch in the granulation, and power on the granulator; Meanwhile, spray syrup and the bacterial powder of bacillus coagulans HQ-1 until the required pellet cores are produced, and then take them out; 3) The core of the pellets shall be cooled under a temperature of 5-10 C. and be screened for follow-up use; 4) Take the medicine solid gelatin in the warm water bath and then cool it to room temperature to obtain the gel, ready for follow-up use; 5) Step 4) the gel shall be heated to obtain the solution; 6) Take the core of the pellet produced in the step 3, power on the pelletizer. Meanwhile, spray the solution made in the Step 5. Whenever the mixture is even, spray the cold gas into, the granulator till the gel is solidified, and obtain the pellet core wrapped with a hard capsule shell; 7) Weigh and take the pharmaceutical auxiliary ingredients and pellet core in line with the formula proportion, spray the syrup made in step 1) during the granulating process. Whenever the mixture is even, and then press into being tablets.

2. According to right-claim 1, the characteristics of the preparation method is the individual mass proportion of the starch, sucrose and bacterial powder inside the in the pellet core in step 2), subject to the tablet formula.

3. According to right-claim 1, the characteristics of the preparation method is the individual mass proportion of pharmaceutical excipients, sucrose, starch and bacterial powder in the tablet in in step 7), subject to the tablet formula.

Description

SPECIFIC IMPLEMENTATION STEPS

[0023] This case is further specified in combination with the embodiment as follows: In this case, the live bacteria preparation of bacillus coagulans is a tablet; its formula can be the counterpart of live bacteria tablet, in accordance with the existing multi-genre active ingredients.

[0024] The live bacteria tablet is made from the bacterial powder of bacillus coagulans HQ-1, coated with gelatin and cooled, and then made with other pharmaceutical auxiliary ingredients.

[0025] The preparation method of the live bacteria preparation includes the following steps:

[0026] 1) Take sucrose and purified water for heating and dissolving, and then cool down to obtain the syrup, ready for follow-up use;

[0027] 2) Under room temperature, put the starch in the granulation, and power on the granulator; Meanwhile, spray syrup and the bacterial powder of bacillus coagulans HQ-1 until the required pellet cores, are produced, and then take them out;

[0028] 3) The core of the pellets shall be cooled under a temperature of 5-10 C. and be screened for follow-up use;

[0029] 4) Take the medicine solid gelatin in the warm water (50 C.) bath for two hours (mass concentration is bigger than 2%) and then cool it to room temperature to obtain the gel, ready for, follow-up use;

[0030] 5) The gel shall be heated under the temperature of 40 C. to obtain the solution;

[0031] 6) Take the core of the pellet produced in the step 3, power on the pelletizer. Meanwhile, pray the solution made in the Step 5. Whenever the mixture is even, spray the cold gas into the granulator till the gel is solidified, and obtain the pellet core wrapped with a hard capsule shell;

[0032] 7) Weigh and take the pharmaceutical auxiliary ingredients and pellet core in line with the formula proportion, spray the syrup made in step 1) during the granulating process. Whenever the mixture is even, either pills or powder will be obtained in line with the size of pills.

[0033] 8) Before the consolidation of syrup, deliver the finished products of Step 7 to the tablet press so as to obtain the final tablet.

[0034] In step 2), the starch, the individual mass ratio of sucrose and bacterial powder in the pellet core is subject to the tablet formula.

[0035] In step 7), the individual mass ratio of the pharmaceutical auxiliary ingredients, sucrose, starch and bacterial powder in the tablet is subject to the tablet formula.