Thin film valve apparatus using a fluid hole closing membrane

Abstract

A thin film valve includes at least one chamber for storing a fluid required for biological/chemical analysis, a plurality of chamber for performing a biological/biochemical reaction, or connecting, at least one chamber performing the biological or biochemical reaction to enable a movement of the fluid flow, a flow path arranged to communicate with the hole on the flow path, a thin film closing membrane for closing the fluid hole, a thin film valve including the hole and the fluid hole closing membrane, a multilayered plurality of substrates forming the fluid path, the fluid hole and the chamber, a rotatable disk forming the fluid path, fluid hole, the plurality of chambers, a heat generator, laser beam generator heating the thin film valves, a light detector for detecting amount of light passing through the membrane and closing the fluid hole, and a feedback controller for controlling the focusing actuator.

Claims

1. A thin film valve apparatus, the apparatus comprising: channels as flow paths of a fluid; a first fluid hole and a second fluid hole configured to interconnect the channels; a black membrane having the second fluid hole, where the second fluid hole is vertically aligned and connected with the first fluid hole; a membrane chamber for storing the black membrane; a multilayered plurality of substrates forming the membrane chamber, the channels, and the first fluid hole; a laser beam generator disposed below a rotatable disk, and configured to output a laser beam to melt the black membrane; an optical sensor disposed proximate an upper or lower surface of the rotatable disk, and configured to measure an intensity of light passing through the first fluid hole; an actuator configured to vary a focusing distance of the laser beam on the black membrane; a feedback control device configured to control the laser beam generator, in response to the optical sensor measuring the intensity of the light passing through the first fluid hole; and a driving motor for rotating the rotatable disk for generating a centrifugal force to move the melted black membrane into the first fluid hole to have the first fluid hole closed, wherein the multilayered plurality of substrates and the black membrane are integrated into the rotatable disk.

2. A thin film valve apparatus, the apparatus comprising: channels as flow paths of a fluid; a first fluid hole configured to interconnect the channels; a black membrane turning into a gel state when heated; a membrane chamber for storing the black membrane; a laser beam generator disposed below a rotatable disk, and configured to output a laser beam to melt the black membrane; a space chamber connecting with the membrane chamber, wherein the space chamber has the first fluid hole and provides a room for the melted black membrane to move in by a centrifugal force; an optical sensor disposed proximate an upper or lower surface of the rotatable disk, and configured to measure an intensity of light passing through the first fluid hole; an actuator configured to vary a focusing distance of the laser beam on the black membrane; a feedback control device configured to control the laser beam generator, in response to the optical sensor measuring the intensity of the light passing through the first fluid hole; a multilayered plurality of substrates forming the channels, the membrane chamber, the space chamber, and the first fluid hole; and a driving motor for rotating the rotatable disk for generating the centrifugal force to move the melted black membrane from the membrane chamber into the space chamber to have the first fluid hole closed, wherein the multilayered plurality of substrates, and the black membrane are integrated into the rotatable disk.

3. The apparatus of claim 1, the multilayered plurality of substrates further comprising a third hole initially closed by the black membrane: wherein the centrifugal force moves the melted black membrane towards the first fluid hole thereby closing the first fluid hole and at the same time opening the third fluid hole.

4. The apparatus of claim 1, wherein the black membrane comprises one of black vinyl, black hot melt, black thermoplastic resin, black polyester, black coated PVDF, black polyethylene, Polypropylene, polyvinyl chloride, black PET polyethylene terephthalate, Poly-Ethylene-Terephthalate, and other black synthetic materials.

5. The apparatus of claim 2, the multilayered plurality of substrates further comprising a third hole initially closed by the black membrane: wherein the centrifugal force moves the melted black membrane towards the first fluid hole thereby closing the first fluid hole and at the same time opening the third fluid hole.

6. The apparatus of claim 2, wherein the black membrane comprises one of black vinyl, black hot melt, black thermoplastic resin, black polyester, black coated PVDF, black polyethylene, Polypropylene, polyvinyl chloride, black PET polyethylene terephthalate, Poly-Ethylene-Terephthalate, and other black synthetic materials.

Description

BRIEF DESCRIPTION OF DRAWINGS

(1) FIG. 1A and FIG. 1B is thin film valve using thin film adhesive tape according to an embodiment.

(2) FIG. 1C shows two sided adhesive tape formed by using black membrane layer and adhesive membrane layer according to an embodiment.

(3) FIG. 1D shows fluid hole closing membrane in the disk phase using the double-sided adhesive tape according to an embodiment.

(4) FIG. 1E_A, FIG. 1E_B, FIG. 1E_C, FIG. 1F_A, FIG. 1F_B, FIG. 1F_C, FIG. 1G_A, and FIG. 1G_B show the thin film valve uses black membrane utilizing black thermoplastic resin to open fluid hole.

(5) FIG. 2A and FIG. 2D show disk of thin film valve apparatus and controller of thin film valve apparatus according to an embodiment.

(6) FIG. 2B shows azimuth detector according to an embodiment.

(7) FIG. 2C shows laser beam generation system, permanent magnet and focusing actuator installed on the slider according to an embodiment.

(8) FIG. 2E shows independently controlling opening/closing of a plurality of fluid hole closing membranes on the disk according to an embodiment.

(9) FIG. 2F shows the embodiment arranged as the reflection mode structure so that the laser beam generator and optical sensor measure the intensity of the light passing through the thin film closing membrane of the membrane valve using the thin film adhesive tape according to an embodiment.

DESCRIPTION OF EMBODIMENTS

(10) Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. The invention may, however, be embodied in many different forms and should not be construed as being limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. Since purpose, characteristic, and other advantages like above of the present invention particularly explain the embodiment doing with desirable of the present invention with reference to the attached view it will become clearer.

(11) Hereinafter, fluid hole according to an embodiment of the present invention will be describe.

(12) The thin film valve apparatus using the attached fluid hole closing membrane according to a preferred embodiment of the present invention decides to be hereinafter particularly explained.

(13) The configuration description of the thin film valve apparatus 100 using fluid hole closing membrane.

Description of Thin Film Valve 100 Using Fluid Hole Closing Membrane

(14) The above and other aspects will become more apparent by describing in detail exemplary embodiments thereof with reference to the attached drawings in which:

(15) FIG. 1A and FIG. 1B show the cross-sectional view that another embodiment of the membrane valve using the thin film adhesive tape which includes the membrane valve 100 is implemented by the thin film closing membrane 30 in which three support layers 1, 2, 3 is formed by layered and bonding.

(16) According to an embodiment of the present invention, thin film valve 100, for controlling fluid flow, accommodating a fluid hole closing membrane 30 on a region of a first fluid hole and opening a second fluid hole on the fluid closing membrane 30 by melting, tearing, or breaking a first fluid hole with laser beam's heat. The thin film valve 100 arranges a plurality of the first fluid holes 10 installed on the disk to be opened and closed independently. An embodiment of the present invention recommends 1 mm-5 mm diameter and 0.001 mm-0.2 mm width of fluid hole closing membrane 30, and a black body film or black membrane that easily melts or tears with low powered laser by absorbing all the light energy or generated from laser beam generator 107 or laser module 103.

(17) Disk 200 of the FIG. 1D includes the upper portion substrate 1, and the intermediate substrate 2 and the lower part substrate 3. Fluid hole connecting the fluid paths channel, 22a, 22c in which each of them is the fluid in the substrate surface for the injection molding process flows, the chambers chamber, 20, and 21 which stores the buffer solution and the fluid path is formed with plural number. It is adhered so that substrates 1, 2, 3 stick to thin film adhesive tape layers 1a, 2a and forming a single body disk 200.

(18) A DISK 200 of FIG. 1D having upper substrate 1, intermediate substrate 2 and lower substrate 3, during the injection molding process, forms a plurality of the first fluid hole that connect fluid holes or channels 22a, 22c for flowing fluid on the substrate surface, chambers 20, 21 for storing buffer fluid. The substrates 1, 2, 3 are bonded and multi-layered by a first adhesive tape 1a.

(19) The Fluid hole closing membrane 30 of the thin film valve 100 is layered between the upper substrate 1 and intermediate substrate 2, formed on the a first fluid hole region 10 when bonded the substrates 1,2 by the first thin film adhesive tape 1.

(20) The intermediate 2 and the second thin film adhesive tape 2a which is layered between the lower part substrate 3 and combines substrates 2, 3 are included.

(21) Specifically, chambers 20,21 are formed on the lower substrate 3 and intermediate substrate 2, a first chamber 20 and a first fluid path engraved to the predetermined depth for connecting a first fluid hole are formed on the intermediate substrate 2, a second chamber 21 and a second fluid path 22c for connecting a first fluid hole 10 are formed on the upper substrate 1, a first fluid hole 10 is formed on the end parts of the fluid paths 22a, 22c for connecting the first chamber 20 and the second chamber 21.

(22) The fluid hole 10 is closed by the fluid hole closing membrane 30. The fluid hole closing membrane 30 is formed on the fluid hole 10 when bonding the substrates 1, 2, and 3 with thin film adhesive tape 1a.

(23) According to an embodiment of the present invention, the thin film valve apparatus includes a black body as the thin film closing membrane 30 is burnt with heat.

(24) The thin film valve apparatus an embodiment of the present invention, the substrate junction is transparent blocks the laser and not heated when radiating light while thin film closing membrane 30 is black and easily destroyed by heat from source apparatus.

(25) The light protection at the substrate junction is preferred by covered the upper portion substrate 1 of the disk substrate except for the perforation closing membrane or the lower part substrate 3 with CD label as a coating sheet or coated them with the light protector. Area except for the thin film closing membrane the laser beam is blocked by the CD label to the light barrier coating.

(26) According to an embodiment of the present invention, the thin film valve apparatus includes completely blocking the first thin film hole 10 with the thin film closing membrane 30 for circulation and retention period, forming a second fluid path on the thin film closing membrane 30 and opened by the heat of the heater or heating apparatus, which is stored in the first chamber 20 with the rotation of the disk 200 and moved to the second chamber 21 with fluid pressure formed on the fluid itself.

(27) The thin film closing membrane 30 has the advantage that the problem that the sealing is hindered does not occur among circulation and retention period with the reason like the evaporation of liquid because of well adapting to the expansion according to the environmental factors like the temperature and contraction since being pliable with the physical properties phase.

(28) According to an embodiment of the present invention, it is preferred that in fluid paths 22a, 22c, the hydrophobic coating is preferred to prevent before opening the membrane valve from liquid being flowed into the first fluid hole 10 with the capillary phenomena.

(29) The FIG. 1A-1B shows the first fluid hole 10 is closed (blocked) by the fluid hole closing membrane 30 and fluid paths 22a, 22c are blocked each other, if the first fluid hole 10 be opened and wants to connect fluid paths 22a, 22c, the fluid hole closing membrane 30 is melted and the first fluid hole 10 is opened by the second fluid hole is being formed by the laser beam generator 107 or the laser module 103.

(30) According to an embodiment of the present invention, it is preferred that the first thin film adhesive tape 1a serves as the thin film closing membrane 30.

(31) Referring to FIG. 1A, what foil-coats the first thin film adhesive tape 1a is preferred film coated on both sides of the black membrane 1c with adhesive layers 1b, 1d. Masked region of the fluid hole can be prevented from an adhesive coating when printing by a screen coating.

(32) A thin film adhesive tape 1a includes composed of the black membrane 1c and an adhesive layer 1b, 1d which cover the entire surface of the substrate, the fluid hole closing membrane 30 only in part the adhesive layer is removed, and then the fluid hole closing membrane is formed by the black membrane 1c.

(33) The fluid hole closing membrane 30 may include only black membrane layer 1c, the material of any one selected from the poly ethylene (PE), the polypropylene (PP), black hot melt adhesive, black thermoplastic resin, black vinyl, and the vinyl polyvinyl chloride (PVC).

(34) FIG. 1B shows forming a fluid hole closing membrane 30 according to an embodiment of the present invention, a material of any one selected from a black plastic, black hot-melt adhesive, a black thermoplastic resin for installing a first fluid hole to form the fluid hole closing membrane 30.

(35) Putting a material, any one selected from a black PE poly ethylene, a PP polypropylene, a black PVC vinyl polyvinyl chloride, and a black vinyl, into the first fluid hole region, when bonding a substrate, for forming the fluid hole closing membrane 30.

(36) According to an embodiment of present invention, the black vinyl or the thin film adhesive tape further includes a micro heating particle.

(37) According to an embodiment of the present invention, the fluid hole closing membrane 30 is formed by printing the first fluid hole 10 with the black paint to form a black film.

(38) According to an embodiment of the present invention, the lower part of substrate 3 of the first fluid hole region 10 has a convex lens shape. The convex lens shape is a biconvex lens or a hemisphere convex lens can be used. The convex lens can be made to have convex lens on the lower part substrate 3 of the first fluid hole 10 in the injection molding process by designing.

(39) According to an embodiment of the present invention, the first fluid region 10 of the substrate 1 may further include a reflective film reflector. it has the advantage in which the light passing through the first fluid hole more fuses the thin film closing membrane 30 by the quickly amount of the light coming in into the optical sensor and is checked the laser focusing goes well. The laser beam is in-focus and thin film closing membrane 30 is opened when the intensity of light becomes suddenly stronger over the reference limits, thereby, effectively controls the laser focusing. In the meantime, in this case, the optical sensor has to be installed in the laser beam generator and a reflection mode structure referring to FIG. 2F.

(40) FIG. 1C is a detail view of the black membrane layer 1c and the first thin film adhesive tape 1a formed using adhesive layers 1b, 1d.

(41) Since the thin film closing membrane 30 is torn with the heating since only having the membrane layer 1c and since the membrane layer 1c is black or the micro heating particle is included and the other region, adhesive layers 1b, 1d in which are not heated by the laser beam from the laser beam generator 107 or the laser module 103, the adhesive layers neither physically changed nor torn.

(42) FIG. 1D is an embodiment forming the thin film closing membrane 30 using the first thin film adhesive tape 1a on the disk 200.

(43) It is preferred to be formed so that the first thin film adhesive tape 1a the membrane layer 1c be positioned between the upper portion adhesive layer 1b and lower part adhesive layer 1d. However, it is not limited thereto.

(44) Firstly, if using the masking pattern having the opening part about area the fluid hole closing membrane 30 shape is removed, it prints on the membrane layer c with the adhesive with double side coating and the upper portion adhesive layer 1b and lower part adhesive layer 1d are formed for the thin film closing membrane 30 formation the rest membrane layer 1c area except for the first fluid hole region 10 is coated with the adhesive. Thereafter, the first thin film adhesive tape 1a of the part corresponding to chambers 20, 21 of the disk is removed with the laser cutting. The thin film closing membrane 30 is formed on the first fluid hole region 10 if the upper portion substrate 1 and intermediate 2 of the disk 200 are welded using this.

(45) According to another embodiment of the present invention, a fluid hole closing membrane 30 formation method, includes printing one side of the membrane layer 1c with the adhesive and forming the upper portion adhesive layer 1b and membrane layer 1c the using the masking pattern having the opening part about area the thin film closing membrane 30 shape is taken out after doing the adhesion the rest membrane layer 1c area except for the first fluid hole region 10 is the lower part adhesive layer 1d in which the part which firstly comes under disk chambers 20, 21 for the fluid hole closing membrane 30 formation is removed coated in the upper side of the intermediate 2 of the disk with the adhesive, removing the part corresponding to disk chambers 20, 21 with the laser cutting, and forming the fluid hole closing membrane 30 on the fluid hole region 10 by welding the upper portion substrate 1 and intermediate 2 of the disk 200 using this.

(46) According to another embodiment of the present invention, the thin film closing membrane 30 in the upper portion substrate 1 of the disk 200 using the upper portion adhesive layer 1b which firstly adheres the membrane layer 1c the lower part adhesive layer 1d in which the part which firstly comes under disk chambers 20, 21 for the thin film closing membrane 30 formation is removed to the upper side of the intermediate 2 of the disk after doing the adhesion to the upper part thereafter corresponding to disk chambers 20, 21 and the fluid hole closing membrane 30 shape removed with the laser cutting. A fluid hole closing membrane 30 is formed on the first fluid hole 10 region by welding the first intermediate substrate 1 and intermediate substrate 2.

(47) According to another embodiment of the present invention, patterning of adhesive layers 1b, 1d is caused by laser cutting or press cutting the chamber 20, 21 and fluid hole closing membrane 30.

(48) According to embodiments of the present invention, FIGS. 1e through 1g, as a black membrane, display fluid hole opening/closing thin film valve 100 using black thermoplastic resin 40.

(49) The thin film valve 100 includes an upper substrate 1, an intermediate substrate 2, and a lower substrate 3, and during the injection molding process, each substrate forms the first fluid hole 10 connecting the flow paths 22a 22c.

(50) The substrates 1, 2, 3 are attached to each other in a close contact by the thin film adhesive tape layers 1a, 2a and form a thin film valve 100.

(51) FIG. 1E_A to FIG. 1F_C shows a black hot melt adhesive is preferred as black thermoplastic resin 40 according to embodiments of the present invention

(52) Referring to FIG. 1E_A, and FIG. 1E_B, according to embodiment of the present invention, a thin film valve includes a second fluid hole 11 on the black thermoplastic resin 40 hole 11 and the first fluid hole 10 are connected each other and form a fluid hole.

(53) According to an embodiment of the present invention, the first fluid hole 10 is closed or blocked by melting and removing the second fluid hole 11 formed on a black thermoplastic resin 40 by activating a laser beam generating system 107 or a laser module 103.

(54) FIG. 1E_C shows open first fluid hole 10 and FIG. 1E_B shows closed first fluid hole 10 by removing the second fluid hole 11.

(55) In preferred embodiment, the apparatus includes, melting the black thermoplastic resin 40 of the second fluid hole 11 into a gel state by activating the laser beam generator 107 or the laser module 103 and moving the black thermoplastic resin 40 toward the second fluid hold 11 using centrifugal force by rotating the disk to close the first fluid hole 10. Thereby, at the same time, the second fluid hole 11 is removed and the first fluid hole 10 is closed.

(56) Referring to FIG. 1E_C, thin film 100 includes a membrane chamber 14, which stores a black thermoplastic resin 40, a first hole 10 which connects with the membrane chamber 14, where the membrane chamber has a space 13 where a room for the black thermoplastic resin to move in.

(57) The laser beam generating unit 107 or the laser module 103 melts the black thermoplastic resin 40 to be a gel state.

(58) By moving melted black thermoplastic resin 40 toward the first fluid hole, the first fluid hole is closed.

(59) FIG. 1E_C shows a state where the first fluid hole 10 is open, FIG. 1E_B shows a state where the first hole 10 is closed.

(60) Referring to FIG. 1F_A, FIG. 1F_B, and FIG. 1F_C, by operation of the laser beam generating unit 107 or the laser module unit 103, closing a first fluid hole 10 and opening the third fluid hole 12 at the same time by melting and removing the black thermoplastic resin 40 by a heat an embodiment of the present invention.

(61) FIG. 1F_A shows that the first fluid hole 10 is open and the third fluid hole 12 is closed.

(62) FIG. 1F_B shows that both the first fluid hole 10 and third fluid hole 12 are closed.

(63) It is preferred to close the first fluid hole 10 by operating the laser beam generator 107 or laser module 103 and heating the black thermoplastic resin 40 into a gel state and then moving the black thermoplastic resin 40, by centrifugal force by rotating the disk, toward the first fluid hole 10 and closing or blocking the second fluid hole 11 according to an embodiment.

(64) FIG. 1F_C-FIG. 1F_B show that the laser beam generating system 107 or the laser module 103 is moved toward the third fluid hole 12 and operated to open the third fluid hole 12 by a heat according to an embodiment.

(65) Referring to FIG. 1F_B it is preferred that operating the laser beam-generating apparatus 107 or the laser module unit 103, melting the black thermoplastic resin 40 to be in a gel state by a heat by a laser beam, and then rotating the disk to move the melted black thermoplastic resin 40 toward the first fluid hole 10 by the centrifugal force, and opening the third fluid hole 12.

(66) FIG. 1F_B shows that a laser beam generator 107 or a laser module 103 may easily open the third hole 12 since large portion of black thermoplastic resin 40 have been moved to the first hole 10 region as shown in FIG. 1F_C. When the third hole 12 is open, it is possible to move the liquid from the flow path 22a to the chamber 31.

(67) That is, as shown in FIG. 1F_A, the liquid inputted from the flow path 22a can be moved to the opposite flow path 22c, while, in FIG. 1F_C, a liquid from flow path 22a can be transferred to the chamber 31 through the third hole 12.

(68) In FIG. 1E_C, after the laser beam generating apparatus 107 or the laser module unit 103 is operated to melt the black thermoplastic resin 40 into a gel state, the melted black thermoplastic resin 40 is moved to the first fluid hole 10 by centrifugal force and closing the first fluid hole 10 at the same time opening the third fluid hole 12.

(69) A thin film valve 100 shown in FIG. 1E_C may include the membrane chamber 14 to store black thermoplastic resin 40 to close a third hole 12, a space chamber 13 which connects with the membrane chamber 14 and provides a room for the black thermoplastic resin moved in.

(70) The laser beam-generating apparatus 107 or the laser module unit 103 is operates to melt the black thermoplastic resin 40 and turns the resin into a gel state, and then rotates the disk to move the melted black thermoplastic resin 40 toward the first hole 10 for closing the same and opening the third hole 12.

(71) FIG. 1G_A shows that the first hole 10 is opened and the third hole 12 is closed.

(72) FIG. 1G_B shows that a first hole 10 is closed and a third hole 12 is opened.

(73) In FIG. 1G_B, even if small amount of black thermoplastic resin 40 are remaining, the third fluid hole 12 can be easily open by the laser beam generator 107 or a laser module 103 because large portion of the black thermoplastic resin 40 have moved to the third fluid hole 12 due to centrifugal force.

(74) When the third hole 12 is open, the liquid from the flow path 22a can be moved to the chamber 31. In other words, while, in FIG. 1k, injected liquid is transported from flow path 22a through the first fluid hole 10 to the fluid path 22c. In FIG. 1l, injected liquid is transported from flow path 22a to chamber 31 through the third fluid hole 12.

(75) FIG. 2A shows a thin film valve apparatus includes a controller 100a and a disk 200 according to an embodiment.

(76) FIG. 2A is an example applying the laser beam generator 107 as a heat source apparatus according to an embodiment.

(77) Referring to FIG. 2A, specifically, an apparatus according to an embodiment of present application, may include chambers 20,21 to perform various chemical processes and store all kinds of the buffer solutions necessary for the analysis and fluid paths 22a, 22c to move a fluid and a buffer solution, a thin film valve 100 having a fluid hole closing membrane 30 to open and close a fluid path and a fluid hole, a motor 102 to control for rotating a disk 200, and a controller 100a to selectively open or close a plurality of valve by controlling a permanent magnet 5a and a laser beam controller 107.

(78) Disc 200 is made up of upper substrate 1, intermediate substrate 2 and lower substrate 3 and surfaces of substrates 1,2,3 create plurality of fluid hole that connect flow path 22a 22c for fluid to flow, chamber 20,21 for storing buffer fluid and the fluid hole during injection molding process of substrates 1,2,3. The above substrates 1, 2, 3 are bonded to create the body of the disc 200.

(79) A reference numeral 102 may be referred to a spindle motor or a stepper motor for rotating the disc 200. A reference numeral 201 is a slider 211 on which the movable permanent magnet 5a and a laser beam generator 107 mounted, wherein the slider 211 is controlled by a sliding motor 109 and worm gear connection parts 109a, 109b.

(80) At the start and end of the biological or chemical process, for example, the preparation process, amplification process, mixing process, dilution process, labeling process, and the biological/chemistry reaction process or the cleaning process, independently on/off controller of a plurality of thin film valve can be achieved by melting the thin film membrane by operating the laser bream generator 107, after space addressing by a permanent magnet 5a installed on the slider 211.

(81) According to another embodiment of the present invention, instead of laser beam generator 107 being mounted on the slider 211, a plurality of thin film valve corresponding one to one to a plurality of laser beam generators may be installed on the controller 100a.

(82) At the start of end of biological or chemical process, independent on/off control of plurality of thin film valve can be achieved if the central controller 101 can independently control a plurality of laser beam generators installed on the controller 100a.

(83) Moreover, the laser beam generator 107 may further include the focusing actuator 103 for varying a focal distance of the laser beam.

(84) The central control apparatus 101 may further include the feedback controller 101a for measuring the intensity and amount of a laser beam passing through the thin film closing membrane 30 with the optical sensor and reflecting this to the focusing actuator 103.

(85) According to an embodiment of the present invention, during closing/opening or thin film valve 100, the space addressing regarding the thin film valve 100 precedes radial direction and azimuthal direction space addressing of the disc 200.

(86) The radial direction space addressing of the thin film valve 100 moves the slider 211 in reverse along the radial direction using the slider motor 109.

(87) The slider 211 moves to the center of the disc 200 from the outside of the disc 200 or the direction of outside from the center of the disc 200 along the radial direction of the disc 200 by the slider motor 109.

(88) A reference numeral 151 may be referred to a photo sensor array or a photo diode array for measuring the light quantity of the beam, generated by the laser beam generator 107, passing and coming out from the disk 200 or the thin film closing membrane 30.

(89) According to an embodiment of the present invention, a linear image sensor, or a line image sensor, as an example, as the photo sensor array 151 senses the light quantity by unit of the pixel, is preferred. An embodiment of the present invention, a linear sensor array or a Contact Image Sensor CIS is preferred as the linear image sensor. However, it is not limited thereto.

(90) The structure where the optical sensor the photo sensor array 151 lines up to the radial direction in a row is preferred. The photo sensor array may be installed face up with the laser beam generator 107 and disc is there between. The photo sensor array 151 measure the light quantity passes through the disc 200 or the thin film closing membrane 30 and comes out. The laser beam generator 107 is mounted on the slider 211 and it is transferable of the radial direction of the disc 200. Therefore it is necessary to have the photo sensor array 151 which lines up in the radial direction to measure the light quantity of the laser beam generator 107 in the position of the arbitrary radial direction.

(91) An embodiment of the present invention, a space addressing of the azimuthal direction for the membrane valve 100 may be performed by radiating a continuous beam or a pulse beam outputted from the laser beam generator 107 on the disc 200 which is in a stationary state or a rotation operation state after the space addressing of the radial direction is completed.

(92) In a state where the pulse beam or the continuous beam the radius direction space addressing described in the above is completed, it is preferred that whenever the thin film closing membrane 30 meets the laser beam if the laser beam generator 107 is continuously operated while rotating the disc 200, and then heats are accumulated by the beams and a fluid hole is opened.

(93) According to an embodiment of the present invention, a method of opening a thin film valve using a continuous beam includes, in a state the radius direction space addressing as described above is completed, operating the laser beam generator 107 continuously while rotating the disc 200 at the same time rotating the stepping motor 102 slowly, the intensity of the light from the photo sensor array 151 becomes suddenly stronger, the search of the membrane valve 100 is achieved in the relevant position, The stepping motor 102 continually heats the thin film closing membrane 30 the rotation in the stop state and the perforation is opened.

(94) In this case, it is preferred that it is covered with the CD label using the external side of the upper portion substrate 1 among substrates 1,2,3 except for the thin film closing membrane 30 or the lower part substrate 3 is the coating sheet or the light protection is coated.

(95) Area except for the thin film closing membrane 30, the laser beam is blocked by the CD label or the light barrier coating. Thus, the photodiode array 151 can receive a strong light in a position of a perforation closing membrane 30. Compared to the other area of the disc 200, there is no adhesive layer at the thin film closing membrane 30 area. Thus, transmittance of light rate of the thin film closing membrane 30 is different from other area. Therefore, while the rotation of the disc 200, the intensity of a received light from the photo sensor array 151 suddenly can change in the thin film closing membrane 30 position and it can be used for searching a direction angle position of the thin film closing membrane 30.

(96) Moreover, since the intensity of the received light from the photo sensor array 151 suddenly increases in a case the fluid hole is opened, the central control equipment 101 recognizes opening and closing of the fluid hole. If the intensity of light does not increase to enough extent even after enough heating it determines that there is an error and continues to the rotation of the disc 200 and the azimuth search toward the position of the membrane valve 100.

(97) Another embodiment of the present invention, instead of the photo sensor array 151, an optical sensor arranged a reflection mode structure and the laser beam generator 107 may be mounted on the slider 211.

(98) Another embodiment of the present invention, to make widening the opening area of perforation closing membrane 30 of the membrane valve 100, after the space addressing is completed and focusing the laser beam generator 107 by controlling the vertical direction with focusing actuator 103, opening the thin film closing membrane 30 by moving the laser beam generator 107 to right and left horizontal direction of the slider 211 number of millimeter or rotating disc 200 a little bit with the motor 102. In the direction angle position of the corresponding membrane valve 100 calculated based on the standard trigger signal in which the pulse beam is obtained with the azimuth detector 99, it periodically makes the operation on done the laser beam generator 107 is formed. The reference trigger signal refers as an azimuth reference.

(99) An embodiment of the present invention, preferably, the azimuth detector 99 is a photo coupler. According to an embodiment of the present invention, it is preferred that the azimuth detector 99 is a reflection or translucent type.

(100) An embodiment of the present invention, opening and closing method of the plurality of membrane valves 100, on the disc 200 with the laser beam generator 107 and permanent magnet 5a mounted on the slider 211, may be performed by the space addressing of the radial direction and space addressing of the azimuthal direction, respectively.

(101) According to an embodiment of present invention, a plurality of membrane valves 100 and corresponding the photo diodes and laser beam generation systems of the plurality of membrane valves are accommodated in the control unit 100a, thereby opening and shutting of each of the plurality of the membrane valve may be controlled by the control unit.

(102) According to an embodiment of present invention, a flexible cable 101b supplies the control signals for controlling the focusing actuator 103 and laser beam generator 107 on the slider 211, is connected to the central control equipment 101 through a harness 110a, harness and a feedback controller 101a supplies control signal for controlling a focusing actuator 103. Instead, a wafer can be used as the harness 110a. A turn table 181 may load the disc 200 through the central opening 170 by way of a front or a top loading.

(103) A memory-embedded wireless radio frequency IC 188 may include the protocol, an analysis algorithm, a standard control value for the read, and location information about the assay site, the bioinformatics information, and the related information, self-diagnosis for the disc 200. Moreover, the identification ID of the disc 200 and individual encryption information can be stored on the memory-embedded wireless radio frequency IC 188 for not the disc used by an unauthorized person. The smart IC card form is preferred for the wireless radio frequency IC 188.

(104) The information of the wireless radio frequency IC 188 is provided to the central controller 101 through a wireless transmission and may be used for the individual password. A radio wave generating unit 110 supplies power source to the wireless radio frequency IC 188.

(105) An embodiment of the present invention, enough amount of the electricity is produced and supplied the power source to the wireless radio frequency IC 188 the electric wave by the reacts the induction coil installed in the wireless radio frequency IC 188 according to the Fleming's rule.

(106) An embodiment of the present invention, the lighting device 108 may further included for supplying the light energy to the solar cell 189 on the disc 200. Preferably, the lighting device 108 is a high intensity LED module of multiple high intensity LEDs or a lamp.

(107) Preferably, according to an embodiment of the present invention, through the wireless radio frequency IC 188, the specific identification of the disc 200 wirelessly is transmitted to central controller 101 at a loading point of time of the disc 200. The central controller 101 recognizes that the disc loaded in the control unit 100a of the thin film valve apparatus is an authenticated disk.

(108) Preferably, according to an embodiment of the present invention, the controller 100a may further include the I/O unit 111. The I/O unit 111 may have one of the standards for telecommunications among group including USB Universal Serial Bus, the IEEE1394, ATAPI, the SCS I, IDE and wire and wireless internet communication network.

(109) FIG. 2B shows an azimuth detector 99 according to an embodiment of the present invention. A pulse beam may be generated by periodically operating the laser beam generator 107 at the direction angle position of the corresponding membrane valve calculated based on a reference trigger signal from the azimuth detector 99. The reference trigger signal represents an azimuth reference of the disc 200.

(110) A rotation angle position signal or a reference trigger signal may be obtained by the azimuth detector photo coupler 99 which includes the light generator 99a and an optical detector 99b.

(111) Preferably, according to an embodiment of the present invention, the azimuth detector 99 may be a mirror projection or a translucent method. In case of the translucent, if only, the photo coupler 99 meets with the reference hole 98a on the disc 200 while rotating the disc 200, the reference trigger signal is generated and then provided to the central control equipment 101.

(112) In case of the mirror projection, whenever the photo coupler 99 meets the reference reflector 98b for the rotation of the disc 200, the standard trigger signal is generated with the reference reflector 98b and photo coupler 99 and is provided to the central control equipment 101. Synchronized with the reference trigger signal, the central control equipment 101 operates the laser beam generator only at the position of the corresponding membrane valve and the corresponding membrane valve is selectively heated while rotating the disc 200.

(113) FIG. 2C is an upper view of the slider 211 according to an embodiment.

(114) According to an embodiment of the present invention, the laser beam generator 107, the permanent magnet 5a and focusing actuator 103 are installed arrange as shown. The slider 211 is transferred and controlled with worm gear connection parts 109a, 109b connected to the slide motor 109 shaft. The slider 211 slides down by using slide arms 108a, 108b as a guide.

(115) The slide arms 108a, 108b are connected to the body of the control unit 100a through screws 110a, 110b, 110c, and 110d. The flexible cable 110b is connected to the central control equipment 101 with the wafer or the harness 110a. The turn-table 181 rotates with the motor 102.

(116) FIG. 2D shows a thin film valve apparatus includes a control unit 100a and the disc 200, according to an embodiment of present invention.

(117) A body 300 supports control unit 100a. The circuit board 140 under the control unit 100a is connected to the control unit 100a. the central controller 101, which is an element of the a part of controller 100a, a radio wave generating unit 110, and the lighting device 108 and I/O unit 111 are installed on the circuit board 140.

(118) The central controller 101 controls the motor 102 for the rotation or the pause of the disc 200, controls the laser beam generator 107 and movement of a permanent magnet 5a on the slider 211 by controlling the slide motor 109 and controls the laser beam generator 107 by periodically outputting a pulse beam at the direction angle position of the corresponding membrane valve calculated based on the standard trigger signal controlling the space transition of the and is obtained with the azimuth detector 99.

(119) Preferably, according to an embodiment of the present invention, the central controller 101 may provide users' guide, according to the kind of the disc 200 loaded in the turn-table 181 of the control unit 100a and provide the user the audio synthesis for additional explanation to the user. Preferably, according to an embodiment of the present invention, the idle table 104 can compress on the disc 200 settled by in the turn-table 181 through the disc air gap with the magnetic force attractive force between the idle table and the turn-table 181, and move vertically and rotate idly.

(120) FIG. 2E is an apparatus for individually controlling opening and closing plurality of perforation closing membranes 30a, 30b, 30c, 30d, 30e, 30f arranged on the disc 200 an embodiment of the present invention.

(121) Specifically, after addressing the space corresponding to the reference point of the disc based on thin film cylinder magnet 5a and permanent magnet 5b, utilizing each laser beam generators 107a, 107b, 107c, 107d, 107e, 107f corresponding to perforation closing membrane 30a, 30b, 30c, 30d, 30e, 30f of the thin film valve, the central controller 101 independently controls the on/off of each thin film valve.

(122) According to an embodiment of the present invention, a laser beam to be focused on the surface of the thin film closing membrane 30 to concentrate a thermal energy.

(123) Therefore, the thin film valve apparatus of the present invention includes laser beam generators 107a, 107b, 107c, 107d, 107e, 107f and focusing actuators 103a, 103b, 103c, 103d, 103e, 103f, for focusing laser beam corresponding to each thin film valve 100 on one side of the disc 200 and photo diodes to optical sensors on the other side of the disc to measure the quantity of the laser beams that came through the thin film closing membrane 30.

(124) FIG. 2D is an embodiment of the present invention a laser beam generator and optical sensor which is arranged as the transmission mode structure to measure intensity of the light passing through the thin film closing membrane 30. According to an embodiment of the present invention, the focal distance of the laser beam of the focusing actuator 103 is controlled by an electromagnet coil and a permanent magnet.

(125) According to an embodiment of the present invention, the focal distance of the laser beam the focusing actuator 103 is controlled by a piezo device. The scan focus mode which scans while the feedback controller 101a controls the focusing actuator 103 and varies the focal distance of the laser beam generator 107 with the maximum value in the minimum value and calculates the focal distance is preferred. In this case, the intensity of the laser light, which penetrates the thin film closing membrane 103 if the focus is correct among the scan process, is getting stronger. The feedback controller 101a receiving the change of this light through the optical sensor 150 with the feedback controls and focuses the focusing actuator 103.

(126) Moreover, it is seen that after it focuses the thin film closing membrane is opened if the intensity of the light sensed with the optical sensor 150 becomes suddenly stronger. Referring to FIG. 2F_A to 2F_C, a reflective film 4 is further accommodated on the upper portion substrate 1 and both the laser beam generator 107 and optical sensor 150 are arranged in the reflection mode structure to measure the intensity of the light passing through the thin film closing membrane 30 of the perforation 10 site.

(127) It is preferred to operate the laser beam generator 107 after the radial search and azimuthal direction search about the membrane valve 100 which the reflection mode structure opens and open the thin film closing membrane 30. In this case, the optical sensor 150 is accommodated under the disc 200 like as the laser beam generator 107 does. The intensity of the light in which reflected the optical sensor 150 has been turning the reflective film 4 back around is observed with the scan focus mode for the scan and the moment when the intensity of light becomes stronger unlike can know that it is easy to the focusing of the laser beam at the thin film closing membrane 30.

(128) While scanning using the scan focus method, the optical sensor 150 determines the increase of the focus of the returned laser beam on the thin film closing membrane 30, by checking observing the intensity of beam reflected by the reflective film.

(129) Moreover, whether or not the thin film closing membrane 30 is opened can be determined if the intensity of the light sensed with the optical sensor 150 becomes suddenly stronger after focusing.

(130) Preferably, the reflective film are an aluminum, a gold, and a silver coating according to an embodiment of the present invention.

(131) In the above, it described the embodiment doing with desirable of the present invention. But the invention is not restricted in the specific embodiment. That is, the multiple changes and correction about the invention if it grows up to go to the normal knowledge from the technical field in which the invention belongs thought and category of the attached patent claim are deviated from are made possible. And it should be considered that the equivalent of the correction and such all proper changes belong to the scope of the present invention.

(132) An embodiment of the present invention, the lighting device 108 may further included for supplying the light energy to the solar cell 189 on the disk 200.

(133) Preferably, the lighting device 108 is a high intensity LED module of multiple high intensity LEDs or a lamp.

(134) Preferably, according to an embodiment of the present invention, through the wireless radio frequency IC 188, the specific identification of the disk 200 wirelessly is transmitted to central controller 101 at a loading point of time of the disk 200. The central controller 101 recognizes that the disk loaded in the control unit 100a of the thin film valve apparatus is an authenticated disk.

(135) Preferably, according to an embodiment of the present invention, the controller 100a may further include the I/O unit 111.

(136) The I/O unit 111 may have one of the standards for telecommunications among group including USB Universal Serial Bus, the IEEE1394, ATAPI, the SCS I, IDE and wire and wireless internet communication network.

(137) FIG. 2B shows an azimuth detector 99 according to an embodiment of the present invention. A pulse beam may be generated by periodically operating the laser beam generator 107 at the direction angle position of the corresponding membrane valve calculated based on a reference trigger signal from the azimuth detector 99. The reference trigger signal represents an azimuth reference of the disk 200.

(138) A rotation angle position signal or a reference trigger signal may be obtained by the azimuth detector photo coupler 99 which includes the light generator 99a and an optical detector 99b.

(139) Preferably, according to an embodiment of the present invention, the azimuth detector 99 may be a mirror projection or a translucent method. In case of the translucent, if only, the photo coupler 99 meets with the reference hole 98a on the disk 200 while rotating the disk 200, the reference trigger signal is generated and then provided to the central control equipment 101.

(140) In case of the mirror projection, whenever the photo coupler 99 meets the reference reflector 98b for the rotation of the disk 200, the standard trigger signal is generated with the reference reflector 98b and photo coupler 99 and is provided to the central control equipment 101.

(141) Synchronized with the reference trigger signal, the central control equipment 101 operates the laser beam generator only at the position of the corresponding membrane valve and the corresponding membrane valve is selectively heated while rotating the disk 200.

(142) FIG. 2C is an upper view of the slider 211.

(143) According to an embodiment of the present invention, the laser beam generator 107, the permanent magnet 5a and focusing actuator 103 are installed as shown. The slider 211 is transferred and controlled with worm gear connection parts 109a, 109b connected to the slide motor 109 shaft. The slider 211 slides down by using slide arms 108a, 108b as a guide.

(144) The slide arms 108a, 108b are connected to the body of the control unit 100a through screws 110a, 110b, 110c, and 110d. The flexible cable 110b is connected to the central control equipment 101 with the wafer or the harness 110a. The turn-table 181 rotates with the motor 102.

(145) FIG. 2D shows a thin film valve apparatus includes a control unit 100a and the disk 200, according to an embodiment of present invention.

(146) A body 300 supports control unit 100a. The circuit board 140 under the control unit 100a is connected to the control unit 100a. the central controller 101, which is an element of the a part of controller 100a, a radio wave generating unit 110, and the lighting device 108 and I/O unit 111 are installed on the circuit board 140. The central controller 101 controls the motor 102 for the rotation or the pause of the disk 200, controls the laser beam generator 107 and movement of a permanent magnet 5a on the slider 211 by controlling the slide motor 109 and controls the laser beam generator 107 by periodically outputting a pulse beam at the direction angle position of the corresponding membrane valve calculated based on the standard trigger signal controlling the space transition of the and is obtained with the azimuth detector 99.

(147) Preferably, according to an embodiment of the present invention, the central controller 101 may provide users' guide, according to the kind of the disk 200 loaded in the turn-table 181 of the control unit 100a and provide the user the audio synthesis for additional explanation to the user. Preferably, according to an embodiment of the present invention, the idle table 104 can compress on the disk 200 settled by in the turn-table 181 through the disk air gap with the magnetic force attractive force between the idle table and the turn-table 181, and move vertically and rotate idly.

(148) FIG. 2E is an apparatus for individually controlling opening and closing plurality of perforation closing membranes 30a, 30b, 30c, 30d, 30e, 30f arranged on the disk 200 an embodiment of the present invention.

(149) Specifically, after addressing the space corresponding to the reference point of the disk based on thin film cylinder magnet 5a and permanent magnet 5b, utilizing each laser beam generators 107a, 107b, 107c, 107d, 107e, 107f corresponding to perforation closing membrane 30a, 30b, 30c, 30d, 30e, 30f of the thin film valve, the central controller 101 independently controls the on/off of each thin film valve.

(150) According to an embodiment of the present invention, a laser beam to be focused on the surface of the thin film closing membrane 30 to concentrate a thermal energy.

(151) Therefore, the thin film valve apparatus of the present invention includes laser beam generators 107a, 107b, 107c, 107d, 107e, 107f and focusing actuators 103a, 103b, 103c, 103d, 103e, 103f, for focusing laser beam corresponding to each thin film valve 100 on one side of the disk 200 and photo diodes to optical sensors on the other side of the disk to measure the quantity of the laser beams that came through the thin film closing membrane 30.

(152) FIG. 2D is an embodiment of the present invention a laser beam generator and optical sensor which is arranged as the transmission mode structure to measure intensity of the light passing through the thin film closing membrane 30.

(153) According to an embodiment of the present invention, the focal distance of the laser beam of the focusing actuator 103 is controlled by an electromagnet coil and a permanent magnet.

(154) According to an embodiment of the present invention, the focal distance of the laser beam the focusing actuator 103 is controlled by a piezo device. The scan focus mode which scans while the feedback controller 101a controls the focusing actuator 103 and varies the focal distance of the laser beam generator 107 with the maximum value in the minimum value and calculates the focal distance is preferred. In this case, the intensity of the laser light, which penetrates the thin film closing membrane 30 if the focus is correct among the scan process, is getting stronger. The feedback controller 101a receiving the change of this light through the optical sensor 150 with the feedback controls and focuses the focusing actuator 103.

(155) Moreover, it is seen that after it focuses the thin film closing membrane is opened if the intensity of the light sensed with the optical sensor 150 becomes suddenly stronger. Referring to FIG. 2f, a reflective film 4 is further accommodated on the upper portion substrate 1 and both the laser beam generator 107 and optical sensor 150 are arranged in the reflection mode structure to measure the intensity of the light passing through the thin film closing membrane 30 of the perforation 10 site. It is preferred to operate the laser beam generator 107 after the radial search and azimuthal direction search about the membrane valve 100 which the reflection mode structure opens and open the thin film closing membrane 30. In this case, the optical sensor 150 is accommodated under the disk 200 like as the laser beam generator 107 does.

(156) While scanning using the scan focus method, the optical sensor 150 determines the increase of the focus of the returned laser beam on the thin film closing membrane 30, by observing the intensity of beam reflected by the reflective film 4.

(157) Moreover, whether or not the thin film closing membrane 30 is opened can be determined if the intensity of the light sensed with the optical sensor 150 becomes suddenly stronger after focusing.

(158) Preferably, the reflective film are an aluminum, a gold, and a silver coating according to an embodiment of the present invention.

(159) In the above, it described the embodiment doing with desirable of the present invention. But the invention is not restricted in the specific embodiment. That is, the multiple changes and correction about the invention if it grows up to go to the normal knowledge from the technical field in which the invention belongs thought and category of the attached patent claim are deviated from are made possible. And it should be considered that the equivalent of the correction and such all proper change s belong to the scope of the present invention.