PHOTOREACTOR

Abstract

The photoreactor comprises at least one housing (11) for at least one reaction vessel and at least one light source for lighting said at least one reaction vessel, and the photoreactor comprises: a first module (1) provided with said at least one housing (11) for at least one reaction vessel and comprising a cooling/heating circuit (15) for regulating the temperature of said at least one reaction vessel; a second module (2) provided with said at least one light source; and a thermal insulating layer (5) placed between the first module (1) and the second module (2).

It improves reproducibility of the reactions by temperature and light intensity control.

Claims

1-15. (canceled)

16. A photoreactor, comprising at least one housing (11) for at least one reaction vessel and at least one light source for lighting said at least one reaction vessel, wherein the photoreactor comprises: a first module (1) provided with said at least one housing (11) for at least one reaction vessel and comprising a cooling/heating circuit (15) for regulating the temperature of said at least one reaction vessel; a second module (2) provided with said at least one light source; and a thermal insulating layer (5) placed between the first module (1) and the second module (2); characterized in that the first and second modules (1, 2) and said thermal insulating layer (5) are fixed to each other, and in that the first and second modules (1, 2) and said thermal insulating layer (5) have substantially the same area and wherein the first and second modules (1, 2) are separated by said thermal insulating layer (5)

17. The photoreactor according to claim 16, wherein the first module (1) comprises a plurality of first housings (11) and the second module (2) comprises a plurality of light sources, the position of the first housings (11) matching with the position of the light sources, and the thermal insulating layer (5) being provided with holes (51) or being transparent for permitting the light from the light sources to reach the reaction vessels in said first housings (11).

18. The photoreactor according to claim 16, wherein the second module (2) comprises a plurality of second housings (21), each second housing (21) being for one or more light sources.

19. The photoreactor according to claim 18, wherein each second housing (21) comprises focusing means (24).

20. The photoreactor according to claim 16, wherein it comprises a plurality of light sources mounted on one or more supports (26) comprising an integrated electronic circuit.

21. The photoreactor according to claim 16, wherein said second module (2) comprises a cooling/heating circuit (25) for regulating the temperature of the light sources.

22. The photoreactor according to claim 17, wherein said second module (2) comprises a cooling/heating circuit (25) for regulating the temperature of the light sources.

23. The photoreactor according to claim 20, wherein said second module (2) comprises a cooling/heating circuit (25) for regulating the temperature of the light sources.

24. The photoreactor according to claim 21, wherein the cooling/heating circuit (25) comprised in said second module is a circuit for a liquid fluid.

25. The photoreactor according to claim 22, wherein the cooling/heating circuit (25) comprised in said second module is a circuit for a liquid fluid.

26. The photoreactor according to claim 23 wherein the cooling/heating circuit (25) comprised in said second module is a circuit for a liquid fluid.

27. The photoreactor according to claim 16, wherein the at least one light source is a Light Emitting Diode.

28. The photoreactor according to claim 25, wherein the at least one light source is a Light Emitting Diode.

29. The photoreactor according to claim 26, wherein the at least one light source is a Light Emitting Diode.

30. The photoreactor according to claim 16 further comprising a power source (6).

31. The photoreactor according to claim 30, wherein said power source (6) is connected to an external control device (7).

32. The photoreactor according to claim 16 further comprising a calibrating module (8) for calibrating of the light intensity from said at least one light source.

33. The photoreactor according to claim 32, wherein the calibrating module (8) is placed on said first module (1).

34. The photoreactor according to claim 16, wherein said thermal insulating layer (5) has a thermal conductivity lower than 0.3 watt per meter and per Kelvin.

35. The photoreactor according to claim 16, wherein said thermal insulating layer (5) consists of polytetrafluoroethylene (PTFE) or polycarbonate (PC).

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0021] For a better understanding of what has been disclosed, some drawings are attached in which, diagrammatically and only as a non-limitative example a specific embodiment is shown.

[0022] FIG. 1 is an exploded perspective view of the first and second modules and the thermal insulating layer of the photoreactor according to the present invention;

[0023] FIG. 2 is an exploded perspective view of the second module of the photoreactor according to an alternative embodiment of the present invention;

[0024] FIG. 3 is a diagrammatical view of the heating/cooling circuit of the first module; and

[0025] FIG. 4 is a block diagram of the connection between the modules, the power source, the control device and the calibration module.

DESCRIPTION OF A PREFERRED EMBODIMENT

[0026] With reference to FIG. 1, the parallel photoreactor of the invention is formed by two independent modules provided with a plurality of openings:

[0027] a first module 1 provided with a plurality of housings 11 for reaction vessels, said reaction vessels being preferably tubes placed into the housings 11, the first module 1 having a height enough for covering completely the height of the reaction vessels, and

[0028] a second module 2 provided with a plurality of housings 21 for placing light sources, such as LEDs 3, each housing 21 being provided with a lens 22 or another suitable focusing means.

[0029] The modules 1, 2 are separated by a thermal insulating layer 5 made of, for example, Teflon or polycarbonate layer and fixed to each other preferably by screws. This thermal insulating layer 5 can comprise a plurality of holes 51 (corresponding to the housings 11, 21 of the first and second modules 1, 2) or it can be transparent, to permit the passage of light from the LEDs to the reaction vessels.

[0030] The first module 1 comprises a central piece 13 and two lateral pieces 12. The central piece 13 can be made of any material having high thermal conductivity, such as metals and composite materials, preferably aluminum. The central piece 13 can be further coated with an electrically insulating layer (obtainable by anodization).

[0031] The shape and dimensions diameter of the housings 11 housing the reaction vessels must be adapted to the shape of the reaction vessels. Cylindrical housings are preferred when the reaction vessel is a flask or a vial. In such a case, the diameter of the housing corresponds to the diameter of the reaction vessel.

[0032] The height of the first module 1 needs to be sufficient to cover the height of the solutions of reactant and reagents in the reaction vessels. Typically, the size of the reaction vessels can range from 250 microliters to 250 ml, while the height of the reaction vessel can range from 0.5 cm to 30 cm. Typically, the height of the first module 1 is between 1 cm and 20 cm (preferably from 1-5 cm).

[0033] The central piece 13 of the first module 1 further comprises a pair of connectors 14 (entry and exit connectors) allowing a cooling/heating liquid to enter/exit a cooling/heating circuit 15 of the central piece 13. A cooling/heating liquid flows through the cooling/heating circuit of the central piece 13 in such a way that each housing 11 is surrounded by one or more channels of flowing cooling/heating liquid.

[0034] As shown in FIG. 3, in a preferred embodiment, the cooling/heating liquid flows from the entry connector 14 through a channel running the whole length of the central piece 13, then turning 90 and turning another 90 once passed the closest housing 11 to run the whole length of the central piece 13, and repeating this sequence until reaching the exit connector 14.

[0035] To this central piece 13 it can be fixed (e.g. by screwing) a lid (not shown in the drawings) preventing possible leakages of the cooling/heating system. A sealing gasket may be placed between the central piece 13 and the lid and/or between the central piece 13 and the lateral pieces 12.

[0036] The lid can be made of any material that would not suffer prolonged exposure to the cooling/heating fluid, such as plastics and metals. Typically, the lid is made of aluminum.

[0037] The second module 2 also comprises a central piece 23 and two lateral pieces 22. The features of the central piece 23 are similar to those of the central piece 13 for the first module 1 (materials, cooling system, dimensions) and the features of the lateral pieces 22 are similar to those of the lateral pieces 12 of the first module 1 (materials, fixation).

[0038] A sealing gasket may be placed between the central piece 23 and the lateral pieces 22.

[0039] Each housing 21 in the second module 2 comprises focusing means 24. The focusing means 24 may consist of a lens made of glass or plastic mounted on a plastic support which can be placed into a housing 21. In this design, a thermally conductive adhesive, such as an epoxy resin is used to fix the lens 24 inside the housing 21.

[0040] At least one light source, such as a LED, is fixed into each housing 21 (1 to 10 LEDs, preferably 1 to 3 LEDs, for regulating the light intensity), using a thermally conductive adhesive such as an epoxy resin. Each LED is connected through electrical wires to an external power source 6.

[0041] Advantageously, since the second module 2 includes a cooling/heating circuit 25 equivalent to the circuit 15 of the first module 1, high-power LEDs can be used. The LEDs can be connected electrically in series or in parallel. The LEDs comprised in the same row/column form a channel, each channel being connected to a transformer, and wherein each channel can be controlled independently through the power source 6, which allows controlling the intensity of light irradiation.

[0042] The power source 6 may further comprise a wireless emissor/receptor (e.g. by Bluetooth) allowing remote control of each transformers feeding the channels through an external wireless control device 7 (computer, mobile phone, tablet, etc.) and a suitable software interface.

[0043] In an alternative embodiment, the central piece 23 of the second module 2 can comprise at least one support 26 comprising an integrated electronic circuit connecting contact positions where one or more light sources, such as LEDs, are mounted. In this case, the focusing means 24 are mounted on top of the contact positions.

[0044] In this design, the support 26 represents a channel and is connected to the power source 6 through standard electric wiring and a multipin connector embedded in the central piece 23 of the second module 2. Each channel is connected to the multipin connector through electrical wires.

[0045] The power source 6 is a power supply including a number of channels that corresponds to the number of row or columns in the photoreactor, with low ripple output and hardware control. The power source 6 has the capacity to regulate independently the current intensity and voltage outputs of different channels. This control avoids the damage of the LEDs but also allows for adjusting and calibrating the final LEDs light intensity. Likewise, a channel switch on protocol is implemented to prevent LEDs damage. This power supply can be controlled/programmed via USB or Bluetooth.

[0046] The photoreactor according to the present invention may further comprise a calibration module 8 placed on top of the first module 1 and eventually separated from the first module 1 through a separation layer (not shown in the drawings) made of a transparent material (glass, PC, PMMA, plexiglass) and comprising for each housing 11 or row/column of housings 11 a light intensity measuring system combining a calibrated photodiode, which measures the light intensity, an analogic digital converter that converts the value of current intensity to a digital value, and a microcontroller, which controls the data acquisition and communication with the PC/tablet and a Bluetooth shield for communications.

[0047] The device is designed to measure the light intensity from one or more LEDs or/and the real current intensity applied to each LED.

[0048] Optionally, the first and second modules 1, 2 and the thermal insulating layer 3 can be placed in a dry box for preventing condensation and they can also be subjected to stirring by conventional stirring means, preferable an orbital shaker and glass beats to ensure equal stirring in all the positions and maximize the light passing though the solution since magnetic stirring with magnetic bars cause shadows and led to no homogeneous stirring.

[0049] The operation of the photoreactor according to the present invention is the following.

[0050] First a calibration step is carried out by the calibration module 8. For this, the calibration module 8 is placed on the first module 1 and the photoreactor is switched on. The calibration module 8 controls that the suitable light intensity reaches the samples in the reaction vessels and, if necessary, changes the parameters for providing the suitable light intensity. This calibration step is not carried out every time the photoreactor is operated, but according to preset intervals such as, e.g. once a week.

[0051] The operation of the photoreactor begins placing the reaction vessels inside the housings 11 of the first module 1 and turning on the LEDs in the second module 2. The user can control, e.g. by an external device 7 (tablet or smartphone) the temperature and light intensity for improving the reproducibility of the reactions.

[0052] Even though reference is made to a specific embodiment of the invention, it is apparent for a person skilled in the art that the photoreactor is susceptible of numerous variations and modifications, and all the details cited can be substituted by other technically equivalent ones, without departing from the scope of protection defined by the attached claims.