MIXING APPARATUS AND METHOD FOR OPERATING A MIXING APPARATUS
20200171450 ยท 2020-06-04
Inventors
- Stefan Zeuch (Goettingen, DE)
- Markus Haeusser (Goettingen, DE)
- Stefan Weisshaar (Adelebsen, DE)
- Jens Ludwig (Juehnde, DE)
Cpc classification
B01F2035/3513
PERFORMING OPERATIONS; TRANSPORTING
B01F35/513
PERFORMING OPERATIONS; TRANSPORTING
B01F27/808
PERFORMING OPERATIONS; TRANSPORTING
International classification
Abstract
A mixing apparatus (1) for mixing a fluid and/or solid. The mixing apparatus includes a mixing container (100), in the interior of which the fluid and/or solid can be arranged, and a feed-through (10) through a container wall (101) of the mixing container (100). A drive shaft (50), fed through the feed-through (10), is used to drive a stirring element (30), which is arranged at least partly in the interior of the mixing container (100), in order to mix the fluid and/or solid, arranged in the mixing container (100). A drive-side shaft end (51) of the drive shaft (50) is used to couple a drive (120), arranged outside of the mixing container (100), to the drive shaft (50). An adjustable seal (70) seals off the feed-through (10), wherein the adjustable seal (70) can be put into at least two sealing operation states having different sealing effects.
Claims
1. Mixing apparatus for mixing a fluid and/or a solid, comprising: a mixing container comprising a container wall, defining an interior and configured to contain the fluid and/or the solid; a feed-through extending through the container wall of the mixing container; a stirring element arranged at least partly in the interior of the mixing container; a drive shaft extending through the feed-through and configured to drive the stirring element to mix the fluid and/or the solid contained in the mixing container; wherein the drive shaft comprises a drive-side shaft end configured to couple a drive arranged outside of the mixing container to the drive shaft; and an adjustable seal that produces a first sealing effect with respect to the feed-through in a first sealing operation state and produces a second sealing effect with respect to the feed-through that differs from the first sealing effect in a second sealing operation state.
2. Mixing apparatus, as claimed in claim 1, wherein the adjustable seal seals the feed-through in a sealing state as the first sealing operation state; and the adjustable seal is opened in an open state that does not seal the feed-through as the second sealing operation state.
3. Mixing apparatus, as claimed in claim 2, wherein the adjustable seal lies against the drive shaft in the sealing state and is at least partially spaced apart from the drive shaft in the open state.
4. Mixing apparatus, as claimed in claim 2, wherein the adjustable seal is completely spaced apart from the drive shaft in the open state.
5. Mixing apparatus, as claimed in claim 2, wherein the adjustable seal is configured: to assume the sealing state when the drive is positioned not to drive the drive shaft, and to assume the open state when the drive is positioned to drive the drive shaft.
6. Mixing apparatus, as claimed in claim 1, further comprising a setting apparatus for switching the adjustable seal between the first sealing operation state and the second operation state.
7. Mixing apparatus, as claimed in claim 6, wherein the setting apparatus is mounted to displace in axial directions of the drive shaft.
8. Mixing apparatus, as claimed in claim 6, wherein the setting apparatus is substantially ring shaped around the drive shaft.
9. Mixing apparatus, as claimed in claim 1, further comprising a setting apparatus for switching the adjustable seal between producing the first sealing effect and producing the second sealing effect, wherein the setting apparatus is substantially conical, so as to taper towards a narrow end of the setting apparatus that is pointed towards the adjustable seal .
10. Mixing apparatus as claimed in claim 9, wherein the adjustable seal tapers towards a narrow end of the adjustable seal such that the narrow end rests sealingly against the drive shaft in the first sealing operation state, and rests against the setting apparatus in the second sealing operation state.
11. Mixing apparatus, as claimed in claim 1, further comprising a particle separator arranged in the feed-through.
12. Mixing apparatus, as claimed in claim 11, wherein the particle separator is arranged on a container-side end of the feed-through.
13. Mixing apparatus, as claimed in claim 1, wherein the adjustable seal is substantially ring shaped around the drive shaft.
14. Mixing apparatus, as claimed in claim 1, further comprising: a housing arranged at the feed-through and defining an interior, wherein the drive shaft is movably mounted in the interior of the housing.
15. Mixing apparatus, as claimed in claim 14, wherein the adjustable seal is arranged between the drive shaft and the housing and comprises a movable sealing region.
16. Mixing apparatus, as claimed in claim 14, wherein the housing comprises a reinforcement on a drive-side end of the feed-through.
17. Mixing apparatus, as claimed in claim 1, further comprising at least one additional, permanent seal, which seals the feed-through independently of the sealing operation states of the adjustable seal.
18. Mixing apparatus, as claimed in claim 1, wherein the drive is arranged outside of the mixing container, for driving the drive shaft and/or the mixing container, in the interior of which the fluid and/or the solid is contained.
19. Mixing apparatus, as claimed in claim 1, wherein the mixing container, in the interior of which the fluid and/or the solid is contained, comprises an at least partially flexible container wall; and/or is configured as a bioreactor bag and/or as a mixing bag.
20. Mixing apparatus, for mixing a fluid and/or a solid, comprising: a mixing container comprising a container wall, defining an interior and configured to contain the fluid and/or the solid; a feed-through extending through the container wall of the mixing container; a stirring element arranged at least partly in the interior of the mixing container; a drive shaft extending through the feed-through and configured to drive the stirring element to mix the fluid and/or the solid contained in the mixing container, wherein the drive shaft comprises a drive-side shaft end configured to couple a drive arranged outside of the mixing container to the drive shaft; a housing arranged at the feed-through and defining an interior, wherein the drive shaft is movably mounted in the interior of the housing; an adjustable seal that produces a first sealing effect with respect to the feed-through in a first sealing operation state and produces a second sealing effect with respect to the feed-through that differs from the first sealing effect in a second sealing operation state, wherein the adjustable seal annularly surrounds the drive shaft, and the housing annularly surrounds the adjustable seal; and a setting apparatus that annularly surrounds the drive shaft, for switching the adjustable seal between the first sealing operation state and the second sealing operation state, wherein the adjustable seal is arranged between the drive shaft and the housing, wherein the adjustable seal contacts the housing and extends radially from the housing to the drive shaft in the first sealing operation state, and wherein the adjustable seal contacts the housing and extends radially from the housing to the setting apparatus in the second sealing operation state.
21. Mixing apparatus, as claimed in claim 20, wherein the adjustable seal comprises a static sealing region at least in a circumferential area in which the adjustable seal contacts the housing, and comprises a movable sealing region at least in a circumferential area in which the adjustable seal contacts the drive shaft and/or the setting apparatus.
22. Method for operating a mixing apparatus for mixing a fluid and/or a solid, comprising: receiving the fluid and/or the solid in an interior of a mixing container; mixing the fluid and/or the solid, contained in the mixing container, with a stirring element, arranged at least partly in the interior of the mixing container; driving the stirring element with a drive shaft, which is driven by a drive, which is arranged outside of the mixing container and which extends through a container wall of the mixing container at a feed-through; and arranging an adjustable seal for placing the feed-through into one of at least two sealing operation states having mutually different sealing effects.
23. Method, as claimed in claim 22, wherein said arranging comprises: placing the adjustable seal into a sealing state as a first sealing operation state, in which the adjustable seal seals the feed-through; and placing the adjustable seal into an open state as a second sealing operation state, in which the adjustable seal does not seal the feed-through and/or seals the feed-through only incompletely.
24. Method, as claimed in claim 23, wherein the first sealing operation state corresponds to an idle state, in which the drive shaft is not driven, and wherein the second sealing operation state corresponds to a drive state, in which the drive shaft is driven.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
[0049]
[0050]
[0051]
[0052]
[0053]
[0054]
[0055]
DETAILED DESCRIPTION
[0056]
[0057] The mixing apparatus 1 comprises a drive 120, which may be designed, for example, as a motor, in particular, as an electric motor. The drive 120 drives a drive shaft 50, which is fed through a feed-through 10 into the interior of the mixing container 100. The drive 120 is used to drive a stirring element 30, which is arranged in the interior of the mixing container 100 and is designed and provided for mixing a medium in the interior of the mixing container 100.
[0058] The drive 120, the mixing container 100 and/or the stirring element 30 may be designed as part of the mixing apparatus 1. As an alternative, one, two or all three of these components may be designed as a respective separate component, which is not designed as part of the mixing apparatus 1, but rather only for coupling to the mixing apparatus 1.
[0059] The mixing container 100 may be designed as a mixing bag and/or as a bioreactor bag. The mixing container 100 has a container wall 101, which may be at least partly formed of a flexible material, such as a flexible plastic material. The mixing container 100 may include an inlet port 102, through which the fluid and/or the solid may be filled into and/or drained out of the interior of the mixing container 100. In the exemplary embodiment shown, the inlet port 102 is arranged on one end of the mixing container 100, where said end is designed so as to be opposite the feed-through 10 in the container wall 101.
[0060] In one exemplary embodiment the feed-through 10 may be arranged at a lower end of the mixing container 100. The inlet port 102 may be arranged, for example, on an upper end of the mixing container 100.
[0061] In one exemplary embodiment the mixing container 100 may also be designed as a pallet tank for receiving a solid.
[0062]
[0063] The drive shaft 50 is arranged in the interior of the feed-through 10, which is designed at an opening in the container wall 101 of the mixing container 100. In this embodiment the feed-through 10 is designed as a shaft feed-through, inside of which the drive shaft 50 is fed through the container wall 101. In this case the drive shaft 50 is arranged in such a way that it pierces and/or passes through the container wall 101 of the mixing container 100. The feed-through 10 comprises a housing 40, which may be formed, for example, of a thermoplastic material. The drive shaft 50 is mounted in the housing 40. The housing 40 can be designed and provided for both supporting the drive shaft 50 and/or for improved sealing.
[0064] The stirring element 30 may have a plurality of stirring blades 31, which protrude into the interior of the mixing container 100. In the exemplary embodiment shown, the stirring element 30 has four stirring blades 31. In other embodiments the stirring element 30 may include more or fewer stirring blades 31. As an alternative, the stirring element 30 may also have a different shape, for example, may be formed in a spiral and/or bowl shaped manner.
[0065] The feed-through 10 is designed as a connection between the drive 120 and the stirring element 30. In the embodiment shown, the feed-through 10 is arranged locally between the stirring element 30 and the drive 120.
[0066]
[0067] On the drive-side feed-through end 11 of the feed-through 10 a drive-side shaft end 51 protrudes from a drive-side housing opening 41 out of the housing 40. The drive-side shaft end 51 is designed and provided to be contacted by the drive 120 and/or the clutch 121. In particular, the drive 120 can be coupled to the drive-side shaft end 51 through the clutch 121.
[0068] The housing 40 is designed so as to be substantially rotationally symmetrical in the shape of a cylinder, the cylinder axis of which coincides with the axis of rotation R. The housing 40 may be designed so as to be substantially circular in the cross section along a plane, arranged perpendicular to the axis of rotation R, in particular, substantially along its entire cylinder height. The housing 40 may change its (cylinder) diameter once or several times along the axis of rotation R.
[0069] The housing 40 has a central housing region 45, which has the smallest housing diameter in the exemplary embodiment shown. In this case the term housing diameter is defined as the expansion of the housing 40 perpendicular to the axis of rotation R, i.e., in the radial direction. Adjacent to the drive side and the stirring side at the central region 45, the housing 40 has in each case a region, which is widened in relation to the central region 45, i.e., a housing region having a housing diameter that is widened in relation to the central region 45.
[0070] On the drive side the housing 40 (for example, adjacent to the central housing region 45) has a first housing shoulder 43, which has a wider housing diameter than the central housing region 45. On the stirring side the housing 40 has a second housing shoulder 44, which may be, for example, adjacent to the central region 45 on the stirring side and which may have a wider housing diameter compared to said central region. At the transition of the central housing region 45 to both the first housing shoulder 43 and the second housing shoulder 44, the housing 40 has in each case a housing stage.
[0071] A flange 13 is formed on a stirring-side and/or container-side feed-through end 12 of the feed-through 10. The flange 13 reinforces the container wall 101 of the mixing container 100 and may be designed as a mixing container receptacle and/or reinforcement. The flange 13 may be designed as part of the mixing container 100 and/or as part of the feed-through 10. In the exemplary embodiment shown, the second housing shoulder 44 extends with a substantially constant housing diameter from the central housing region 45 as far as up to the stirring-side feed-through end 12, on which the flange 13 is formed.
[0072] The first housing shoulder 43 extends with a substantially constant housing diameter from the drive-side end of the central region 45 as far as up to a third housing shoulder 46 of the housing 40.
[0073] The third housing shoulder 46 has a housing diameter, which is widened in relation to the first housing shoulder 43. The third housing shoulder 46 extends with a substantially constant housing diameter from the drive-side end of the first housing shoulder 43 as far as up to the drive-side end of the feed-through 10. The drive-side housing opening 41, which is formed in a substantially ring shaped manner around the drive shaft 50, is designed and arranged on this drive-side feed-through end 11.
[0074] The housing 40 comprises a cavity from the drive-side feed-through end 11 as far as up to the stirring-side feed-through end 12, in which the drive shaft 50 is arranged and/or in which it is laid. In this case the drive shaft 50 may protrude from the cavity, enclosed by the housing 40, and, in particular, on both the drive side and the stirring side.
[0075] A reinforcement 90, in particular, a reinforcing ring, which may be designed, for example, as a metallic reinforcing ring, may be designed at least partly around the third housing shoulder 46. Reinforcement 90 is designed and provided to mechanically reinforce and/or stabilize the third housing shoulder 46. For this purpose, the reinforcement 90 may be designed in the shape of a ring around the axis of rotation R of the drive shaft 50 and may be formed radially outwards around the third housing shoulder 46 of the housing 40.
[0076]
[0077] The drive shaft 50 is formed so as to be substantially rod-shaped and extends from the drive-side shaft end 51 to its stirring-side shaft end 52 along the axis of rotation R. In this case the drive shaft 50 passes completely through the housing 40 of the feed-through 10 from the drive-side feed-through end 11 as far as up to the stirring-side feed-through end 12. In particular, the drive shaft 50 passes though the container wall 101 of the mixing container 100, shown only partially in
[0078] On the stirring-side shaft end 52 of the drive shaft 50, the drive shaft 50 is coupled to the stirring element 30. For this purpose, a connector 32 is provided that may be designed, for example, as a screw. The connector 32 may be designed and arranged partially in the interior of the drive shaft 50 and partially in the interior of the stirring element 30 and may provide a positive and/or non-positive connection between the stirring element 30 and the drive shaft 50. The drive shaft 50 is mounted in the interior of the housing 40 through at least one bearing. In the exemplary embodiment shown, the drive shaft 50 is mounted in the interior of the housing 40 with a first bearing 61 and a second bearing 62 in a manner allowing rotation about the axis of rotation R. The two bearings 61 and 62 are spaced apart from one another in the direction of propagation of the axis of rotation R. In this case the first bearing 61 is designed in the interior of the first housing shoulder 43, and the second bearing 62 is designed in the interior of the second housing shoulder 44. The first bearing 61 and the second bearing 62 may be designed in each case as a deep groove ball bearing.
[0079] The first bearing 61 is clamped between a housing stage at the transition from the central housing region 45 to the first housing shoulder 43, on the one hand, and a snap ring 63, on the other hand, in such a way that it is substantially non-displaceable and/or immovable along the axis of rotation R. The second bearing 62 is clamped between the housing stage at the transition from the central housing region 45 to the second housing shoulder 44, on the one hand, and a second snap ring 64, on the other hand, in such a way that it is substantially non-displaceable and/or immovable along the axis of rotation R.
[0080] A respective seal is designed on the side of the respective bearing 61 and 62, which faces the stirring element 30. In this way a first seal 65 is arranged between the first bearing 61 and the housing stage of the housing 40. Between the second bearing 62 and the second snap ring 64 there is arranged a second seal 66. The first seal 65 and/or the second seal 66 may each be designed as a permanent seal, in particular, as a radial shaft sealing ring. The first and/or second seal(s) 65 and/or 66 is/are designed in each case as a dynamic seal. This means that the respective seal 65 or 66 rests in a sealing manner against both movable and immovable parts of the mixing apparatus 1. In this embodiment both the first seal 65 and the second seal 66 are arranged between the movable drive shaft 50 and the housing 40, thus, sealing these two components of the mixing apparatus 1 off from each other. The first seal 65 and the second seal 66 dynamically seal the feed-through 10 between the drive shaft 50 and the housing 40, for example, against leakage of the medium out of the mixing container 100 during the mixing process.
[0081] The housing 40 may be formed of a thermoplastic material that may be welded by way of the flange 13 to the mixing container 100, which may also be formed of plastic.
[0082] On the stirring-side feed-through end 12, a stirring-side housing opening 42 is formed, from which the drive shaft 50 protrudes out of the housing 40 along the axis of rotation R. On the stirring-side feed-through end 12, in particular, in and/or at the stirring-side housing opening 42, a particle separator 67 is designed that can be sealed by a particle separator seal 68. The particle separator seal 68 may be designed, for example, as an O-ring and is arranged in the radial direction between the particle separator 67 and the housing 40, in particular, a stirring-side end of the second housing shoulder 44. The particle separator 67 may be designed and provided to leave some or all of the particles, generated inside the housing 40 during operation, inside the housing 40, and, in so doing, outside of the mixing container 100. The particle separator 67 may also be designed and provided to form a barrier and a protection for the second seal 66, in particular, against alkalis, acids and/or abrasive materials from the interior of the mixing container 100.
[0083] The first housing shoulder 43, the first bearing 61, the first snap ring 63 and the first seal 65 may each be designed as a drive-side component of the feed-through 10, i.e., as a drive-side housing shoulder 43, as a drive-side bearing 61, as a drive-side snap ring 63 and/or as a drive-side seal 65.
[0084] The second bearing 62, the second housing shoulder 44, the second snap ring 64 and/or the second seal 66 may each be designed as a respective stirring-side component of the feed-through 10, i.e., as a stirring-side housing shoulder 44, as a stirring-side bearing 62, as a stirring-side snap ring 64 and/or as a stirring-side seal 66.
[0085] The drive shaft 50, which may be formed of a plastic material, is fed through the housing 40. The stirring element 30, which may also be formed of plastic, is designed on the stirring shaft end 52. The connector 32 is used for mechanically connecting the drive shaft 50 to the stirring element 30. On the opposite end of the drive shaft 50, i.e., the drive-side shaft end 51, the drive shaft 50 is positively connected to the drive 120 through the clutch 121.
[0086] The housing 40, a major portion of the drive shaft 50, the clutch 121 and the drive 120 are arranged outside of the mixing container 100. In this case the housing 40 is adjacent to at least the mixing container 100 or the mixing container receptacle. As a result, the housing 40 of the feed-through 10 can protrude at least partly into the interior of the mixing container 100. The flange 13 may be arranged, for example, inside the mixing container 100.
[0087] The third housing shoulder 46 of the housing 40 is designed adjacent to the drive-side feed-through end 11. In the exemplary embodiment shown, the third housing shoulder 46 has a substantially constant housing diameter, which is designed so as to be larger than the housing diameter of the first housing shoulder 43 and/or the second housing shoulder 44 and, thus, also larger than the housing diameter of the central housing region 45.
[0088] In the interior of the third housing shoulder 46 an adjustable seal 70 is provided between a housing wall of the housing 40 and the drive shaft 50. The adjustable seal 70 may be configured as a static seal, in particular, as a static elastomeric seal. The adjustable seal 70 is designed and provided to seal the mixing container 100 during standstill of the mixing apparatus 1. During operation of the mixing apparatus 1, i.e., when the stirring element 30 is being driven, the adjustable seal 70 can be detached from the drive shaft 50 with a setting apparatus 80. In the standstill mode of the mixing apparatus 1, the adjustable seal 70 can be reversibly coupled to the drive shaft 50 again.
[0089] The adjustable seal 70 may be designed in a substantially ring shaped manner around the axis of rotation R and around the drive shaft 50. For this purpose the adjustable seal 70 may have a static sealing region 72, which adapts from radially inwards to the housing 40, more precisely to the third housing shoulder 46 and/or is adjacent thereto. This static sealing region 72 of the adjustable seal 70 is designed so as to be substantially immovable and does not substantially change its shape and/or position and/or its degree of compression in the interior of the housing 40. The static sealing region 72 may be formed in a substantially tube shaped and/or hose shaped manner around the axis of rotation R and spaced apart therefrom.
[0090] A movable sealing region 71 of the adjustable seal 70 is formed substantially adjacent to the static sealing region 72, where said adjustable seal connects the static sealing region 72 to the drive shaft 50 in the sealing operation state shown in
[0091] The reinforcement 90 is designed around the third housing shoulder 46. The reinforcement 90 may be designed, for example, as a metal ring and shrunk onto this part of the housing 40, as a result of which this part of the housing is stabilized.
[0092] The setting apparatus 80 may be designed as a decoupling mechanism. The setting apparatus 80 is designed in a substantially conical manner around the drive shaft 50.
[0093] In this case the setting apparatus 80 has a narrow end 81, which faces the drive-side feed-through end 11 in the position shown. In addition, the setting apparatus 80 also has a wide end 82, which faces away from the feed-through 10 in the embodiment shown. The narrow end 81 is designed as a stirring-side end of the setting apparatus 80, while the wide end 82 is designed as a drive-side end of the setting apparatus 80. The outer diameter of the setting apparatus 80 increases from the stirring-side end 81 to the drive-side end 82; in the exemplary embodiment shown, it increases substantially steadily.
[0094] In the interior the setting apparatus 80 has a passage 83, which is designed as a cavity and through which the drive shaft 50 passes. The setting apparatus 80 is designed so as to be substantially rotationally symmetrical with respect to the axis of rotation R and is arranged around the drive shaft 50 like a sleeve and/or a cuff.
[0095]
[0096]
[0097] In the embodiment shown in
[0098] In
[0099] In the open state of the adjustable seal 70, the static sealing region 72 of the adjustable seal 70 has substantially the same shape, position and compression as in the sealing state. Only the movable sealing region 71 of the adjustable seal 70 is elastically deformed by the mechanical action of the setting apparatus 80. In this case the deformation of the adjustable seal 70 takes place elastically and/or reversibly. In other words, moving the setting apparatus 80 along the axis of rotation R out of the third housing region 46 restores once again the sealing operation state, shown in
[0100] The movement of the setting apparatus 80 may take place and/or be triggered mechanically and/or electrically.
[0101] The adjustable seal 70 may be designed as a seal having a particularly strong sealing effect, in particular, as a seal with a higher sealing effect than the first and/or second seal(s) 65 and/or 66. As a result, a particularly strong and/or high sealing effect can be achieved, in particular, in resting states of the mixing apparatus 1.
[0102] Such a strong sealing effect can be provided and/or caused, for example, by an adjustable seal 70, in particular, by the movable sealing region 71 that lies flush and/or close to the drive shaft 50. This feature would slow down the drive shaft 50 during the mixing operation and/or lead to severe abrasion. Therefore, during operation of the mixing apparatus 1 the adjustable seal 70 is detached from the drive shaft 50, in particular, is arranged so as to be spaced apart from it, with the setting apparatus 80. In operation, the first seal 65 and the second seal 66 continue to seal the interior of the housing against the fluid and/or the solid in the interior of the mixing container 100. In the open state the adjustable seal 70 may be designed so as not to be in contact with the drive shaft 50.
LIST OF REFERENCE NUMERALS AND SYMBOLS
[0103] 1 mixing apparatus [0104] 10 feed-through [0105] 11 drive-side feed-through end [0106] 12 container-side/stirring-side feed-through end [0107] 13 flange [0108] 30 stirring element [0109] 31 stirring blade [0110] 32 connector [0111] 40 housing [0112] 41 drive-side housing opening [0113] 42 stirring-side housing opening [0114] 43 first housing shoulder [0115] 44 second housing shoulder [0116] 45 central housing region [0117] 46 third housing shoulder [0118] 50 drive shaft [0119] 51 drive-side shaft end [0120] 52 stirring-side shaft end [0121] 61 first bearing [0122] 62 second bearing [0123] 63 first snap ring [0124] 64 second snap ring [0125] 65 first seal [0126] 66 second seal [0127] 67 particle separator [0128] 68 particle separator seal [0129] 70 adjustable seal [0130] 71 movable sealing region [0131] 72 static sealing region [0132] 80 setting apparatus [0133] 81 narrow end [0134] 82 wide end [0135] 83 passage [0136] 90 reinforcement [0137] 100 mixing container [0138] 101 container wall [0139] 102 inlet port [0140] 120 drive [0141] 121 clutch [0142] R axis of rotation