Method for producing an aperture plate

Abstract

An aperture plate is manufactured by plating metal around a mask of resist columns having a desired size, pitch, and profile, which yields a wafer about 60 m thickness. This is approximately the full desired target aperture plate thickness. The plating is continued so that the metal overlies the top surfaces of the columns until the desired apertures are achieved. This needs only one masking/plating cycle to achieve the desired plate thickness. Also, the plate has passageways formed beneath the apertures, formed as an integral part of the method, by mask material removal. These are suitable for entrainment of aerosolized droplets exiting the apertures.

Claims

1. A method of manufacturing an aperture plate wafer, the method comprising: providing a substrate, applying a mask over the substrate in a pattern of columns, each column having a top surface; electroplating a plating material around the columns to form a first thickness; continuing electroplating the plating material such that the plating material is over-plated to form a second thickness directly on the top surfaces of the pattern of columns so as to form a plurality of aerosol-forming apertures with entry surfaces with a convex shape in a direction of intended flow through the aerosol-forming apertures and wherein the first thickness is greater than the second thickness; and removing the plated material from the mask and the substrate to provide a wafer of electroplated material with the plurality of aerosol-forming apertures with entry surfaces with a convex shape that are fluidly coupled with a plurality of droplet entrainment openings; and forming the aperture plate wafer into a domed shape to increase a size of the entrainment openings.

2. The method of claim 1, wherein the height of the columns is in the range of 40 to 60 m.

3. The method of claim 1, wherein a width dimension of each column is in the range of 20 m to 40 m.

4. The method of claim 1, wherein a width dimension of each column is in the range of 25 m to 35 m.

5. The method of claim 1, wherein the plurality of aerosol-forming apertures each have a diameter in the range of 2 m to 6 m.

6. The method of claim 1, wherein the height of the columns is in the range of 55 to 65 micrometers.

7. A method of manufacturing an aperture plate wafer, the method comprising: applying a mask over a substrate in a pattern of columns, each column having a frustoconical bottom portion terminating in a convex top surface, wherein a height of each column is greater than a diameter of each column; electroplating a palladium-nickel alloy matrix plating material around the columns to form a first thickness; over-plating the plating material directly on the top surfaces of the pattern of columns to form a second thickness and so as to form a plurality of aerosol-forming apertures, wherein the first thickness is greater than the second thickness; removing the palladium-nickel alloy matrix plated material from the mask and the substrate to provide a wafer of electroplated material with greater than 44,100 aerosol-forming apertures per 650 mm.sup.2 and a plurality of tapered droplet entrainment portions; and forming the aperture plate wafer into a domed shape such that a size of an exit of the tapered droplet entrainment portions increases based on the forming.

8. The method of claim 7, wherein the plating material plated on the convex top surface provide a funnel shaped entrance to the aerosol-forming apertures.

9. The method of claim 8, wherein the aerosol-forming apertures are 2 to 6 micrometers in diameter.

10. The method of claim 8, wherein the aerosol-forming apertures are 2 to 5 micrometers in diameter.

11. The method of claim 7, wherein each of the plurality of aerosol-forming apertures is aligned with one of the plurality of tapered droplet entrainment portions.

12. The method of claim 7, wherein the height of the columns is in the range of 40 to 60 micrometers.

13. The method of claim 7, wherein the height of the columns is in the range of 55 to 65 micrometers.

14. The method of claim 7, wherein a width dimension of each column is in the range of 20 m to 40 m.

15. The method of claim 7, wherein a width dimension of each column is in the range of 25 to 35 micrometers.

16. A method of manufacturing an aperture plate wafer, the method comprising: applying a mask over a substrate in a pattern of columns, each column having a height between 40-50 m, at least some of the columns in the pattern of columns tapering to define a frustoconical bottom portion with a convex top surface; electroplating a plating material around the columns to form a first thickness; over-plating the plating material directly on the top surfaces of the pattern of columns to form a second thickness and so as to form a plurality of aerosol-forming apertures, wherein the first thickness is greater than the second thickness; and removing the plated material from the mask and the substrate to provide a wafer of electroplated material with the plurality of aerosol-forming apertures aligned with tapered entrainment portions with a height of at least 40-50 m based on a height of each column of the mask; forming the aperture plate wafer into a dome shape such that the tapered entrainment portions increase in size and the aperture plate wafer is concave on a side of the apertures.

17. The method of claim 16, wherein a width dimension of each column is in the range of 20 m to 40 m.

18. The method of claim 16, wherein a width dimension of each column is in the range of 25 to 35 micrometers.

19. The method of claim 16, wherein the plating material includes Ni.

20. The method of claim 19, wherein the plating material includes Pd.

Description

DETAILED DESCRIPTION OF THE INVENTION

Brief Description of the Drawings

(1) The invention will be more clearly understood from the following description of some embodiments thereof, given by way of example only with reference to the accompanying drawings in which:

(2) FIGS. 1 to 4 are a series of cross-sectional views showing stages of manufacturing an aperture plate;

(3) FIG. 5 is a cross-sectional view of a stage in an alternative embodiment;

(4) FIG. 6 is a cross-sectional diagram illustrating an alternative approach in which there are tapered openings below the aerosol-forming apertures; and

(5) FIG. 7 shows an aperture plate of the type n FIG. 6 after it has been formed into a dome shape.

Description of the Embodiments

(6) Referring to FIGS. 1 to 4, the following are the main steps to manufacture an aperture plate in one embodiment.

(7) An aperture plate is manufactured by plating metal around a mask of resist columns 2 having a height of about 45 m, a diameter of about 30 m and a separation of about 30 m. The plating is continued so that the metal 3 overlies the top surfaces of the columns until the desired apertures 4 are achieved. This provides the benefits of both photo-defined technology (by reducing the aspect ratio near the aperture region during electroforming) and aperture density by enabling more closely patterned resist islands, with need for only one masking/plating cycle to achieve the desired plate thickness.

(8) In more detail, non-conductive photo-resist 2 is laid on to a mandrel 1 substrate. This is developed to leave the upstanding columns 2 where holes are required. The tops of the columns 2 are approximately convex. The mandrel is placed in an electroforming tank. As the plating continues, the space between the columns 2 of developed photo resist is in-filled with the plating material. This is typically a PdNi alloy matrix, or it could alternatively be Nickel or a Nickel Cobalt alloy matrix.

(9) The plating is initially to the extent shown in FIG. 2 and is continued so that over-plating occurs as shown in FIG. 3. This plating is stopped just in time to create 2 to 6 m holes 4 as shown also in FIG. 3.

(10) The diametrical size accuracy of these holes can be improved by slowing down the plating deposition activity as the holes are being formed. This prevents overshoot resulting in smaller or occluded holes with the possibility of a thicker than desired wafer construction. The 45 m column height is so chosen such that when the plating is stopped (FIG. 3) the holes are typically 2 to 6 m and preferably 2 to 5 m, which is required to produce droplets in the inhalable range for nebulisation, and concurrently the wafer thickness is in the range of 60 to 62 m in one embodiment.

(11) The convex shape of the entry surfaces to the apertures in addition to the concave shape of the overall domed shaped aperture plate (FIG. 7) provides effective funnelling of the liquid towards the aerosol-forming apertures 4, thereby minimising the residual volume of the drug in the nebuliser. When the photo-resist 2 is removed using an appropriate dissolving solvent, the full wafer cross-section is evident as depicted in FIG. 4. The cross-sectional profile under the hole 4 forms passageways directly under and aligned with the apertures. Because they are formed by removal of the column resist they have the same length as the heights of the columns 2. In use, these passageways under the apertures encourage entrainment of the aerosol towards the outlet of the nebuliser, thereby reducing coalescence with the resultant undesirable effect of larger droplets being formed.

(12) In an alternative embodiment (FIG. 5), photo-resist columns 11 have flat top surfaces over which the metal (12) is plated.

(13) As evident from FIG. 6, in a plate 20 the remaining metal may form outlet hole or passageway 24 sides that are tapered towards the aerosol outlet direction. This drawing shows the wafer metal 21 forming aerosol-forming apertures 22. The liquid 23 is aerosolized through the apertures 22 to exit as droplets through the entrainment openings or passageways 24 aligned with and below the apertures 22. Clearly, choice of geometry of the resist columns decides the geometry of the passageways.

(14) FIG. 7 shows an aperture plate 30 with metal 31 forming apertures 32 and droplet entrainment openings 34, after being formed into a dome shape. As noted above, this dome shape together with the convex shape of the metal between the apertures 32 helps to effectively funnel the liquid 33 towards the apertures 32 in order to form droplets, which exit via the entrainment openings 34.

(15) These much larger holes 34 in comparison (to the aperture diameter) can entrain the aerosol, almost into a laminar flow pattern. This reduces turbulence and consequential coalescence which can lead to an undesirable increase in droplet size. These openings may be tapered (FIGS. 6 and 7) or not (FIGS. 1-4).

(16) The resultant wafer 10 has a greater number of holes, greater than 44,100 per 650 mm.sup.2 (square inch, Mesh 210), than the prior art and yet maintains the same aperture plate thickness (approximately 61 m) as many commercially available products. This ensures that the existing drive controllers (128 kHz) already in situ in many hospitals can be used for the aperture plate, alleviating the cost and considerable time required to be expended to develop a bespoke drive controller to ensure that the correct frequency is available to achieve optimum aerosol output. It is also more conducive for meeting and exceeding the fatigue life requirements. As there is single-layer plating it incorporates a fine equiaxed microstructure.

(17) It will be appreciated that the method provides the benefits of both photo-defined technology, partially decoupling the dependence of wafer thickness to resist island patterning distance and increased aperture density, with the process simplicity of electroforming, because it needs only one masking/plating cycle to achieve the desired plate thickness.

(18) Those skilled in the electro-deposition field will appreciate how the plating conditions may be chosen to suit the circumstances, and the entire contents of the following documents are herein incorporated by reference: U.S. Pat. Nos. 4,628,165, 6,235,117, US2007023547, US2001013554, WO2009/042187, and Lu S. Y., Li J. F., Zhou Y. H., Grain refinement in the solidification of undercooled NiPd alloys, Journal of Crystal Growth 309 (2007) 103-111, Sep. 14, 2007. Generally, most electroplating solutions involving Palladium and Nickel would work or Nickel only or indeed Phosphorous & Nickel (14:86) or Platinum. It is possible that a non-Palladium wafer could be plated at the surface (1-3 microns thick) in PdNi to impart more corrosion resistance. This would also reduce the hole sizes if smaller openings were desired.

(19) The resist geometry, such as height, width, and shape, is configured in such a way as to increase the number of holes while maintaining the desired wafer thickness. Further increase of hole density is also possible. For example, the invention in one embodiment achieves an aperture plate of about 4 times the density (moving from 210 to 420 holes per 25 mm (linear inch) or from 44,100 to 176,400 holes per 650 mm.sup.2 (square inch), while still maintaining the typical 60 to 62 m thickness range.

(20) Adjusting the dimensions in FIG. 1, by reducing the column 2 diameter (30 m) and dimensions between the columns 2 to say 15 m has the potential to increase the number of holes to 700 to 850 per 25 mm (linear inch).

(21) The invention avoids need for two-layer photo defined technology to increase the number of holes while maintaining the same wafer thickness. It also solves the problem of using standard plating defined technology as referred to in the Prior Art Discussion with a greater number of holes which will result in a lower thickness wafer, thus requiring significant changes to the core construction, or more typically the drive controller, to find the optimum drive frequency.

(22) The invention finds particular application where faster nebulisation treatment times are required. This is usually required for hand-held devices when aerosol is administrated through the mouth or nasal passages in fully mobile patients. These are typically patients who administer nebulised drugs in a non-hospital setting.

(23) This is in contrast to intubated hospital patients who are typically on mechanical ventilation where treatment times are less important as long as the patient gets the full prescribed dose.

(24) Techniques for vibrating the aperture plates are described generally in U.S. Pat. Nos. 5,164,740; 5,586,550; and 5,758,637, which are incorporated herein by reference. The aperture plates are constructed to permit the production of relatively small liquid droplets at a relatively fast rate. For example, the aperture plates of the invention may be employed to produce liquid droplets having a size in the range from about 2 m to about 10 m, and more typically between about 2 m to about 5 m. In some cases, the aperture plates may be employed to produce a spray that is useful in pulmonary drug delivery procedures. As such, the sprays produced by the aperture plates may have a respirable fraction that is greater than about 70%, preferably more than about 80%, and most preferably more than about 90% as described in U.S. Pat. No. 5,758,637.

(25) In some embodiments, such fine liquid droplets may be produced at a rate in the range from about 2 l (microliters) per second to about 25 l per second per 1000 apertures. In this way, aperture plates may be constructed to have multiple apertures that are sufficient to produce aerosolized volumes that are in the range from about 2 l to about 25 within a time that is less than about one second. Such a rate of production is particularly useful for pulmonary drug delivery applications where a desired dosage is aerosolized at a rate sufficient to permit the aerosolised medicament to be directly inhaled. In this way, a capture chamber is not needed to capture the liquid droplets until the specified dosage has been produced. In this manner, the aperture plates may be included within aerosolisers, nebulizers, or inhalers that do not utilise elaborate capture chambers.

(26) The aperture plate may be employed to deliver a wide variety of drugs to the respiratory system. For example, the aperture plate may be utilized to deliver drugs having potent therapeutic agents, such as hormones, peptides, and other drugs requiring precise dosing including drugs for local treatment of the respiratory system. Examples of liquid drugs that may be aerosolized include drugs in solution form, e.g., aqueous solutions, ethanol solutions, aqueous/ethanol mixture solutions, and the like, in colloidal suspension form, and the like. The invention may also find use in aerosolizing a variety of other types of liquids, such as insulin.

(27) It will be appreciated that the invention allows the production of a wafer from which nebuliser aperture plates are punched in one single plating step and facilitates the creation of a larger number of holes than that known today (typically up to 400%). Also, it facilitates the use of aperture plates which are 60 to 62 m thick. Also, it allows an increase in the number of holes per unit of area while still being able to control the plating thickness to a predetermined dimension.

(28) The above in combination allows the creation of a higher output nebuliser while still maintaining the standard drive controller and core construction all of which is accomplished in a very economical manner.