ANTIMICROBIAL AGENT COMPOSITION AND MANUFACTURING METHOD AND PRODUCT THEREOF
20240016834 ยท 2024-01-18
Inventors
Cpc classification
A61K31/191
HUMAN NECESSITIES
A61K33/14
HUMAN NECESSITIES
A61K33/20
HUMAN NECESSITIES
International classification
A61K33/14
HUMAN NECESSITIES
A61K33/20
HUMAN NECESSITIES
A61K31/191
HUMAN NECESSITIES
A61K33/06
HUMAN NECESSITIES
Abstract
The present invention relates to an antimicrobial agent composition comprising an undiluted mixture solution formed by mixing: 1 to 10 wt % of a mixture comprising 50 to 60 wt % of purified water and chloride in which sodium chloride and calcium chloride which are at a 1:1 ratio are contained; 1 to 2 wt % of a mixture comprising Pueraria lobata root extract and bellflower root extract which are selected from among natural extracts and are at a 1:1 ratio; 5 to 10 wt % of a mixture comprising carbonate based material in which sodium carbonate and sodium bicarbonate which are at a 1:1 ratio are contained; 10 to 15 wt % of a mixture comprising lactic acid and acetic acid among organic acids and their related salts, which are at a 1:1 ratio; and 5 to 10 wt % of chloric acid based compound of inorganic acid.
Claims
1. An antimicrobial agent composition comprising an undiluted mixture solution formed by mixing: 1 to 10 weight % of a mixture comprising 50 to 60 weight % of purified water and chloride in which sodium chloride and calcium chloride which are at a 1:1 ratio, 50 weight %:50 weight %, are contained; 1 to 2 weight % of a mixture comprising Pueraria lobata root extract and bellflower root extract which are selected from among natural extracts and are at a 1:1 ratio, 50 weight %:50 weight %; 5 to 10 weight % of a mixture comprising carbonate based material in which sodium carbonate and sodium bicarbonate which are at a 1:1 ratio, 50 weight %:50 weight %, are contained; 10 to 15 weight % of a mixture comprising lactic acid and acetic acid among organic acids and their related salts, which are at a 1:1 ratio, 50 weight %:50 weight %; and 5 to 10 weight % of chloric acid based compound of inorganic acid.
2. The antimicrobial agent composition of claim 1, wherein 1 kg of the undiluted mixture solution is diluted with 50 to 100 kg of purified water.
3. A method of manufacturing an antimicrobial agent, the method comprising: a first step of selecting the antimicrobial agent composition of claim 1; a second step of converting the composition of the first step into a liquid product by applying heat to the composition at 50 to 60 C. and adding a solubilizer to completely dissolve the composition into liquefied composite material; a third step of forming the liquefied composite material into powder by heat-drying the liquefied composite material of the second step at 60 C.; and a fourth step of manufacturing a tablet product by shaping the heat-dried powder of the third step.
4. A method of manufacturing an antimicrobial agent, the method comprising: a first step of selecting the composition of claim 1; a second step of converting the composition of the first step into a liquid product by applying heat to the composition at 50 to 60 C. and adding a solubilizer to completely dissolve the composition into liquefied composite material; a third step of diluting 1 kg of the liquefied composite material of the second step with 50 to 100 kg of purified water.
5. A tablet product manufactured by the method of manufacturing an antimicrobial agent according to claim 3.
6. A tablet product manufactured by the method of manufacturing an antimicrobial agent according to claim 4.
7. A method of manufacturing an antimicrobial agent, the method comprising: a first step of selecting the antimicrobial agent composition of claim 2; a second step of converting the composition of the first step into a liquid product by applying heat to the composition at 50 to 60 C. and adding a solubilizer to completely dissolve the composition into liquefied composite material; a third step of forming the liquefied composite material into powder by heat-drying the liquefied composite material of the second step at 60 C.; and a fourth step of manufacturing a tablet product by shaping the heat-dried powder of the third step.
8. A method of manufacturing an antimicrobial agent, the method comprising: a first step of selecting the composition of claim 2; a second step of converting the composition of the first step into a liquid product by applying heat to the composition at 50 to 60 C. and adding a solubilizer to completely dissolve the composition into liquefied composite material; a third step of diluting 1 kg of the liquefied composite material of the second step with 50 to 100 kg of purified water.
9. A tablet product manufactured by the method of manufacturing an antimicrobial agent according to claim 7.
10. A tablet product manufactured by the method of manufacturing an antimicrobial agent according to claim 8.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
[0029]
[0030]
[0031]
[0032]
MODES FOR THE INVENTION
[0033] Hereinafter, in order to explain in detail to the extent that a person of ordinary skill in the art to which the present invention pertains can easily implement the technical idea of the present invention, specific embodiments of the present invention will be described as follows.
[0034] An antimicrobial agent composition of the present invention, comprises an undiluted mixture solution formed by mixing: 1 to 10 weight % of a mixture comprising 50 to 60 weight % of purified water and chloride in which sodium chloride and calcium chloride which are at a 1:1 ratio, 50 weight %:50 weight %, are contained; 1 to 2 weight % of a mixture comprising Pueraria lobata root extract and bellflower root extract which are selected from among natural extracts and are at a 1:1 ratio, 50 weight %:50 weight %; 5 to 10 weight % of a mixture comprising carbonate based material in which sodium carbonate and sodium bicarbonate which are at a 1:1 ratio, 50 weight %:50 weight %, are contained; 10 to 15 weight % of a mixture comprising lactic acid and acetic acid among organic acids and their related salts, which are at a 1:1 ratio, 50 weight %:50 weight %; and 5 to 10 weight % of chloric acid based compound of inorganic acid.
[0035] In addition, 1 kg of the undiluted mixture solution may be diluted with 50 to 100 kg of purified water.
[0036] Furthermore, a method of manufacturing an antimicrobial agent of the present invention, comprises: a first step of selecting the antimicrobial agent composition of claim 1 or 2; a second step of converting the composition of the first step into a liquid product by applying heat to the composition at 50 to 60 C. and adding a solubilizer to completely dissolve the composition into liquefied composite material; a third step of forming the liquefied composite material into powder by heat-drying the liquefied composite material of the second step at 60 C.; and a fourth step of manufacturing a tablet product by shaping the heat-dried powder of the third step.
[0037] Moreover, a method of manufacturing an antimicrobial agent of the present invention, comprises: a first step of selecting the composition of claim 1 or 2; a second step of converting the composition of the first step into a liquid product by applying heat to the composition at 50 to 60 C. and adding a solubilizer to completely dissolve the composition into liquefied composite material; a third step of diluting 1 kg of the liquefied composite material of the second step with 50 to 100 kg of purified water.
[0038] In addition, the present invention provides a tablet product and a liquid product manufactured by the method of manufacturing an antimicrobial agent mentioned above.
[0039] As shown in
[0040] The <Table 1> below is based on the official test report of a test that was requested to and performed by the Korea Analytical Testing Research Institute as a test institution. The test was performed by an In vitro test method, and the <Table 1> shows test results of testing reaction states between the bacteria and the Impact sample for 5 minutes after diluting the Impact product to a prescribed concentration. In this case, an inhibition rate (%) of the test result is as follows: Inhibition Rate (%)=(Number of Bacteria in Control GroupNumber of Bacteria in Sample Group)/Number of Bacteria in Control Group.
TABLE-US-00001 TABLE 1 Sample Name: Comparison Table of Impact (Antiviral Agent) vs. Ampicillin 100 (Antibiotic) Test Details Korea Food and Drug Administration (KFDA) Guidelines for Efficacy Test Result Evaluation of External Disinfectants Control Ampicillin (Quasi-Drugs) (2014.6) Group Impact 100 Staphylococcus Inhibition rate 1.5 10.sup.3 Non 8.1 10.sup.1 aureus (%) of number Detected (94.6%) ATCC 6538 of viable cells (99.9%) Concentration of after 5 minutes inoculum [Antibacterial solution power] 1.0 10.sup.3 CFU/mL Escherichia coli Inhibition rate 1.7 10.sup.3 Non Non (E. coli) (%) of number Detected Detected ATCC 8739 of viable cells (99.9%) (99.9%) Concentration of after 5 minutes inoculum [Antibacterial solution power] 1.3 10.sup.3 CFU/mL Salmonella Inhibition rate 1.6 10.sup.3 Non 2.1 10.sup.1 Typhimurium (%) of number Detected (98.6%) ATCC 14028 of viable cells after 5 minutes (99.9%) Concentration of [Antibacterial inoculum power] solution 1.1 10.sup.3 CFU/mL
[0041]
[0042] In the <Table 1>, 1) when a test item of Concentration of inoculum solution of Staphylococcus aureus ATCC 6538 was tested under a condition of an inhibition rate (%) of number of viable cells [Antibacterial power] 1.010.sup.3 CFU/mL after 5 minutes, the test result showed that 8.110.sup.1 CFU/mL of bacteria (Inhibition Rate 94.6%) were detected in the ampicillin 100 group, but there was no bacteria detected in the Impact (antimicrobial agent) of the present invention (Inhibition Rate 99.9%). Accordingly, the test result shows an antibacterial effect of the present invention.
[0043] 2) When a test item of Concentration of inoculum solution of Escherichia coli (E. coli) ATCC 8739 was tested under a condition of an inhibition rate (%) of number of viable cells [Antibacterial power] 1.310.sup.3 CFU/mL after 5 minutes, there were no bacteria detected both in the ampicillin 100 group (control material) and the Impact (antimicrobial agent) of the present invention.
[0044] 3) When a test item of concentration of inoculum solution of Salmonella Typhimurium ATCC 14028 was tested under a condition of an inhibition rate (%) of number of viable cells [Antibacterial power] 1.110.sup.1 CFU/mL after 5 minutes, the test result showed that 2.110.sup.1 CFU/mL of bacteria (Inhibition Rate 98.6%) were detected in the ampicillin 100 group, but there were no bacteria detected in the Impact (antimicrobial agent) of the present invention (Inhibition Rate 99.9%). Accordingly, the test result shows an antibacterial effect of the present invention.
[0045] The present invention was clinically tested to each of groups divided into broiler chicken, broiler chicken breeding, laying hen, pigs, dog, cat, and human (simple clinical test) as follows.
[0046] First, the below are an administration test method and a result for broiler chicken.
[0047] In the first test, referring to <Table 2> in the below, Escherichia coli was diagnosed among 30,000 of Ross breeds at the age of 25 days at a broiler chicken consignment farm in Miyang-myeon, Anseong-si, Gyeonggi-do, Korea, and sepsis and mortality occurred. For the test, the product of the present invention was diluted in drinking water at an appropriate ratio and fed for 3 days. As a result of the test, the mortality disappeared after the administration, the symptoms improved, and feed intake was restored to normal.
TABLE-US-00002 TABLE 2 Administration Test to Broiler Chicken - 1 Test Information Test Result Farm Name Broiler chicken consignment farm [Breed: Ross, Age: 25 days, Population: 30,000] Used Product Impact Administration Escherichia coli was diagnosed at the age of 25 Method days, and sepsis and mortality occurred. The product of the present invention was diluted as a 1:1000 ratio in drinking water and fed for 3 days Test Result After the administration, the mortality disappeared, the symptoms improved, and feed intake was restored to normal.
[0048] In the second test, referring to <Table 3> in the below, infectious bronchitis (corona virus) occurred among 24,000 of Ross breeds at the age of 20 days at the broiler chicken consignment farm mentioned above. The Ross breeds showed initial respiratory symptoms, and feed intake was reduced. Antibiotic (Ampicillin) was administered, but respiratory symptoms persisted. For the test, the product of the present invention was fed at the recommended dosage and was administered in the same way for 3 days. As a result of the test, symptoms improved the next day after the first administration, respiratory symptoms disappeared after administration for 3 days, and feed intake was normalized.
TABLE-US-00003 TABLE 3 Administration Test to Broiler Chicken - 2 Test Information Test Result Farm Name Broiler chicken consignment farm [Breed: Ross, Age: 20 days, Population: 24,000] Location Miyang-myeon, Anseong-si, Gyeonggi-do, Korea Situation Infectious bronchitis (corona virus) occurred Related to among 24,000 of Ross breeds at the age of 20 days. Disease The Ross breeds showed initial respiratory symptoms, and feed intake was reduced. Antibiotic (Ampicillin) s administered, but respiratory symptoms persisted. Administration The 1 L of Impact of the present invention was Method diluted in 1 ton of drinking water for 10,000 to 15,000 and fed for a day and was administered in the same way for 3 days. Test Result After the first administration, symptoms improved the next day; respiratory symptoms disappeared after administration for 3 days; and feed intake was normalized.
[0049] In the third test, referring to <Table 4> in the below, Salmonella occurred among 55,000 of Ross breeds at the Seonghwa foods broiler consignment farm in Susin-myeon, Dongnam-gu, Cheonan-si, Korea, and an average number of mortalities per day was approximately 240. In addition, at the age of 10 days, a total of 2,600 have been killed. For the test, at 12 days of age, the product of the present invention was fed at the recommended dosage for 3 days. As a result of the test, mortality decreased sharply to 50 per day, and drinking water consumption increased. In addition, at the time of shipment, a growth rate was 95.5%, and a weight was 1.6 kg, which was good.
TABLE-US-00004 TABLE 4 Breeding Test to Broiler Chicken - 3 Test Information Test Result Farm Name Seonghwa Foods Broiler Consignment Farm [Breed: Ross, Population: 55,000] Location Susin-myeon, Dongnam-gu, Cheonan-si, Korea Used Product Impact Disease/ Salmonella occurred; an average number of Administration mortalities per day was approximately 240; and Method at the age of 10 days, a total of 2,600 have been killed. At 12 days of age, the product of the present At 12 days of age, the product of the invention was diluted at a ratio of 1 L of the product to 1 ton of drinking water and fed for 3 days. Test Result After the administration of the Impact, mortality decreased sharply to 50 per day; and drinking water consumption increased. At the time of shipment, a growth rate was 95.5%, and a weight was 1.6 Kg, which was good.
[0050] In the fourth test, referring to <Table 5> in the below, a laying hen test 1 was conducted. At the TY farm located in Yeoncheon-gun, Gyeonggi-do, Korea, infectious bronchitis (corona virus) occurred among 2,500 of High-line breeds. A laying rate decreased along with a mortality increase. For the test, the product of the present invention was continuously fed for 5 days at the recommended dosage. The mortality stopped 3 days after administration, an occurrence of abnormal eggs decreased, and the egg laying rate gradually recovered.
TABLE-US-00005 TABLE 5 Test to Laying Hen - 1 Test Information Test Result Farm Name TY farm [Breed: High Line, Population: 25,000] Location Yeoncheon-gun, Gyeonggi-do, Korea Used Product Impact (Antibacterial and antiviral substitute) Disease/ Infectious bronchitis (corona virus) occurred, Administration and a laying rate decreased along with a Method mortality increase. The product of the present invention was diluted at a ratio of 1 L of the product to 1 ton of drinking water and fed for 5 days. Test Result After 3 days after the administration, the mortality stopped; an occurrence of abnormal eggs decreased; and the egg laying rate gradually recovered.
[0051] In the fifth test, referring to <Table 6> in the below, a laying hen test 2 was conducted. At the TY farm located in Ipjyang-myeon, Cheonan-si, Korea, inclusion body hepatitis (adeno virus) occurred among 70,000 of High Line breeds 7, and an average number of mortalities per day was approximately 500 from the age of 12 weeks. For the test, from the second day after the occurrence, the product of the present invention was fed at the recommended dose for 5 days. After administration of this product, mortality rapidly decreased to 50 per day, and from the third day after administration, mortality completely disappeared and returned to normal.
TABLE-US-00006 TABLE 6 Test to Laying Hen - 2 Test Information Test Result Farm Name K farm [Breed: High Line, Population: 70,000] Location Ipjyang-myeon, Cheonan-si, Korea Used Product Impact Disease/ Inclusion body hepatitis (adeno virus) occurred, Administration and an average number of mortalities per day was Method approximately 500 from the age of 12 weeks. Since the second day after the occurrence, Newcosin was diluted at a ratio of 1 L of the product to 1 ton of drinking water and fed for 5 days. Test Result After the administration of the present product, mortality rapidly decreased to 50 per day; and from the third day after administration, mortality completely disappeared and returned to normal.
[0052] In the sixth test, referring to <Table 7> in the below, a pig test 1 was conducted. At a finisher pig farm located in Icheon-si, Gyeonggi-do, Korea, respiratory and reproductive syndrome (PRRS virus) occurred among 1000 breeding pigs of a LDY hybrid breed, which were at the age of 2 to 3 months and weighted 30-40Kg. For the test, the product of the present invention was fed at the recommended dose and fed for 5 days in the same way. As a result of the test, the symptoms improved after 5 days of administration, the respiratory symptoms disappeared from the third day of the administration, and feed intake was normalized.
TABLE-US-00007 TABLE 7 Administration Test to Pig - 1 Test Information Test Result Farm Name Finisher pig farm [Breed: LDY hybrid, Age: 2 to 3 months, Population: 1,000] Location Icheon-si, Gyeonggi-do, Korea Situation Respiratory and reproductive syndrome (PRRS Related to virus) occurred among breeding pigs with 30- Disease 40 Kg of weight. Administration The 1,000 mL of the Impact of the present Method invention was diluted in 1 ton of drinking water and fed daily for 5 days. Test Result After 5 days of the administration, the symptoms were improved; the respiratory symptoms disappeared from the third day of the administration; and feed intake was normalized.
[0053] In the seventh test, referring to <Table 8> in the below, the pig test 2 was conducted. At a finisher pig farm located in Nonsan-si, Chungcheongnam-do, Korea, E. coli diarrhea occurred among 1,000 of weaned pigs of a LDY hybrid, which were weighted 10 to 20 kg. The product of the present invention was fed at the recommended dosage and was fed for 5 days in the same way. After 3 days of the administration, as a result of the test, diarrhea stopped, and symptoms gradually improved.
TABLE-US-00008 TABLE 8 Administration Test to Pig - 2 Test Information Test Result Farm Name Finisher pig farm [Breed: LDY hybrid, Population: 5,000] Location Nonsan-si, Chungcheongnam-do, Korea Situation E. coli diarrhea occurred among 1,000 of weaned Related to pigs, which were weighted 10 to 20 kg. Disease Administration The 1 L of the Impact of the present invention Method was diluted in 1 ton of drinking water and fed daily for 5 days. Test Result After 3 days of the administration, diarrhea stopped; and symptoms gradually improved.
[0054] In the eighth test, referring to <Table 9> in the below, the pig test 3 was conducted. At a batch breeding farm located in in Hwaseong-si, Gyeonggi-do, Korea, white diarrhea (E. coli and rotavirus) occurred among weaned pigs from 200 of brood sows of a LDY hybrid. For each weaned pig, 2 mL of the product of the present invention was diluted in 100 mL of drinking water, orally administrated, and fed for 5 days in the same way. As a result of the test, diarrhea stopped from the next day after the first administration.
TABLE-US-00009 TABLE 9 Administration Test to Pig - 3 Test Information Test Result Farm Name Batch breeding farm [Breed: LDY hybrid, Population: 200] Location Hwaseong-si, Gyeonggi-do, Korea Situation White diarrhea (E. coli and rotavirus) Related to occurred. Disease Administration For each weaned pig, 2 mL of the product of the Method present invention was diluted in 100 mL of drinking water, orally administrated, and fed for 5 days in the same way. Test Result From the next day after the first administration, diarrhea stopped.
[0055] In the ninth test, referring to <Table 10> in the below, the pig test 4 was conducted. At a batch breeding farm located in Haman-gun, Gyeongnam-do, Korea, porcine epidemic diarrhea virus PED (corona virus) occurred among both suckling pigs and 200 of brood sows of a LDY hybrid. For each suckling pig, 2 mL of the product of the present invention was diluted in 100 mL of drinking water and orally administered, and for brood sows and growing pigs were fed at an appropriate dose for 5 days. As a result of the test, diarrhea started to stop on the third day after the administration, and the pigs were recovered after 5 days.
TABLE-US-00010 TABLE 10 Administration Test to Pig - 4 Test Information Test Result Farm Name Batch breeding farm [Breed: LDY hybrid, Population: 200] Location Haman-gun, Gyeongnam-do, Korea Situation Porcine epidemic diarrhea virus PED (corona Related to virus) occurred among both suckling pigs and Disease brood sows. Administration For each weaned pig, 2 mL of the Impact was Method diluted in 100 mL of drinking water, and orally administrated for 5 days. For each brood sow and growing pig, the Impact was diluted at a ratio of 1 L of the product to 1 ton of drinking water, and consistently fed for 5 days. Test Result From the third day after the administration, diarrhea started to stop, and the pigs were recovered after 5 days.
[0056] In the tenth test, referring to <Table 11> in the below, the cat test 1 was conducted. Koshort breeds, which were at the age of 7 months and weighted 2.7 kg, from Bubal-eup, Icheon-si, Gyeonggi-do, Korea, visited the hospital due to bloody diarrhea, and a positive result for feline leukopenia (FP virus) was obtained in the kit test. The blood test showed a 0 count of lymphocyte, a 1.310.sup.3/ul count of white blood cell, and a 4110.sup.3/ul count of platelets, which were significant low levels. Therefore, for the test, 1 mL of the product of the present invention was orally administrated daily for each cat, and after a day from the oral administration, 0.3 mL of the product was administrated every day. As a result of the test, bloody stools stopped 3 days after the administration, but appetite was still poor. The blood test after getting an IV (intravenous injection) showed that a count of lymphocyte was recovered to 2.7, which was normal; a count of white blood cell slightly increased to 38, and a count of platelet was recovered to 333, which was normal.
TABLE-US-00011 TABLE 11 Administration Test to Cat - 1 Species: Cat Breed: Koshort Age: 7 months Sex: Female (neutered) Weight: 2.7 kg Address of Owner: Bubal-eup, Icheon-si, Gyeonggi-do, Korea Disease Feb. 6, 2020: Visited with bloody diarrhea A positive result for feline leukopenia (FP virus) was obtained in the kit test. The blood test showed a 0 count of lymphocyte, a 1.3 10.sup.3/ ul count of white blood cell, and a 41 10.sup.3/ul count of platelets, which were significant low levels. Administration Feb. 6, 2020: Administration of fluids at the same time as hospitalization. Injection of antiserum injection. Feb. 7, 2020: Oral administration of 1 mL of an antiviral agent with no sweeting agents for each cat. After the administration, cat showed vomiting symptoms. Feb. 8, 2020 to Feb. 13, 2020: Oral administration of 0.3 mL of Impact containing a sweeting agent every day. Test Result After 3 days of the administration, bloody stools stopped, but appetite was still poor. Administration of an IV (intravenous injection). Feb. 13, 2020: The blood test showed that a count of lymphocyte was recovered to 2.7, which was normal; a count of white blood cell slightly increased to 38, and a count of platelet was recovered to 333, which was normal.
[0057] In the eleventh test, referring to <Table 12> in the below, the cat test 2 was conducted. A Koshort breed, which was at the age of 6 months and weighted 2.3 kg, from Baeksa-myeon, Icheon-si, Gyeonggi-do, Korea, visited the hospital with a respiratory problem and tentatively determined as feline respiratory disease complex (FRDC) based on sleep discharge and the respiratory problem.
[0058] On Feb. 6, 2020, antibiotics and anti-inflammatory drugs were prescribed, but 6 out of 10 died within 3 days. For the test, 0.2 mL of the Impact, which was mixed with sugar, of the present invention was orally administrated for each cat from Feb. 10, 2020 to Feb. 14, 2020. As a result of the test, the remaining 4 of cats all become healthy without death and were active normally.
TABLE-US-00012 TABLE 12 Administration Test to Cat - 2 Species: Cat Breed: Koshort Age: 6 months Count: 10 stray cats Address of Owner: Baeksa-myeon, Weight: 2.3 kg on Icheon-si, Gyeonggi-do, Korea average Disease: Feb. 6, 2020: Visited with a respiratory problem. Tentatively determined as feline respiratory disease complex (FRDC) based on sleep discharge and the respiratory problem. Administration Feb. 6, 2020: Antibiotics and anti-inflammatory drugs were prescribed, but 6 out of 10 died within 3 days. Feb. 10, 2020 to Feb. 14, 2020: Oral administration of 0.2 mL of Impact containing sugar for each cat. Test Result The remaining 4 of cats all become healthy without death and were active normally.
[0059] In the twelfth test, referring to <Table 13> in the below, the dog test was conducted. A mixed breed, which was male at the age of 1 year and 1 month and weighted 6 kg, from Aeryeonjeong-ro, Icheon-si, Gyeonggi-do, Korea, visited to the hospital with continuous cough, high fever of 40 C., vomiting, and diarrhea and was hospitalized with interstitial pneumonia based on X-ray and examination.
[0060] On the first day, antipyretic, anti-serum, antibiotic, and fluid were administered, and for 3 days thereafter, 0.2 mL of antiviral agent mixed with sugar water was orally administered for each cat. As a result of the test, symptoms improved, and he was discharged from the hospital.
TABLE-US-00013 TABLE 13 Administration Test to Dog Species: Dog Breed: Age: 1 year and Mixed 1 month Sex: Male Weight: 6 kg Address of Owner: Aeryeonjeong-ro, Icheon-si, Gyeonggi-do, Korea, Disease: Jan. 24, 2020: Visited to the hospital with continuous cough, high fever of 40 C., vomiting, and diarrhea and was hospitalized with interstitial pneumonia based on X-ray and examination. Administration First day: Antipyretic, anti-serum, antibiotic, and fluid were administered. 3 Days after the first day: 0.2 mL of antiviral agent mixed with sugar water was orally administered. Test Result The symptoms improved, and he was discharged from the hospital.
[0061] In the thirteenth test, efficacy was tested on humans as a simple clinical trial, and the following results were obtained.
[0062] [Case 1]
[0063] Name: Jo, xxx (male, 54 years old), living in Jeungpo-dong, Icheon-si, Korea infection
[0064] Symptoms: sore throat, high fever, and cold virus infection
[0065] Treatment: After administration of 1 mL of the antibacterial antiviral agent per day for 3 days, the symptoms of cold completely disappeared.
[0066] [Case 2]
[0067] Name: Kim, xxx (female, 63 years old), living in Taepyeong-dong, Seongnam-si, Korea
[0068] Symptoms: Cold symptoms. Even though a cold medicine was administrated for 7 days, the symptoms did not get better.
[0069] Treatment: After administration of 1 mL of the antibacterial and antiviral agent per day for 2 days, the cold was disappeared.
[0070] [Case 3]
[0071] Name: Park, xxx (male, 49 years old), living in Changjeon-dong, Icheon-si, Korea
[0072] Symptoms: sore throat, fever, and cold symptoms.
[0073] Treatment: After administration of 1 ml of antibacterial antiviral agent per day for 3 days, the cold was disappeared.
[0074] [Case 4]
[0075] Name: Kim, xxx (male, 27 years old), living in Bundang-gu, Seongnam-si, Korea
[0076] Symptoms: Sore throat and cold symptoms
[0077] Treatment: 1 mL of the antibacterial and antiviral agent was administered for 2 days, and then the cold was disappeared.
[0078] As described above, although the present invention has been shown and described in relation to the specific embodiments described above, various modifications and changes are possible without departing from the spirit and scope of the invention as indicated by the following claims. Anyone with ordinary knowledge in the relevant technical field will be able to easily understand.