Bactericidal, fungicidal and anti-allergenic <i>Zanthoxylum schinifolium </i>skin care soap and method of preparation

Abstract

The present invention discloses a method of preparing a bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap, wherein the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap comprises the following components based on percentage by weight: Component A: Zanthoxylum schinifolium seed oil 15.0-21.0%, propylene glycol 12.0-17.0%, glycerin 6.0-11.0%, Component B: deionized water 5.0-8.0%, sodium alkyl ether sulfate AES 8.0-12.0%, Component C: lauric acid 5.0-8.0%, stearic acid 11.0-16.0%, Component D: 98% NaOH 2.5-4.5%, deionized water balance, Component E: Zanthoxylum schinifolium essential oil 0.3-0.8%. The skin care soap of the present invention is pale yellow and translucent, has good stability, provides great aroma and rich foam, and can nourish the skin and sterilize effectively.

Claims

1. A bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap comprising based on weight percentage: TABLE-US-00021 Component A: Zanthoxylum schinifolium nut oil 15.0-21.0%, Propylene glycol 12.0-17.0%, Glycerin 6.0-11.0%; Component B: Deionized water 5.0-8.0%, Sodium alkyl ether sulfate AES 8.0-12.0%; Component C: Lauric acid 5.0-8.0%, Stearic acid 11.0-16.0%; Component D: 98% NaOH 2.5-4.5%, Deionized water balance; and Component E: Zanthoxylum schinifolium essential oil 0.3-2%.

2. A bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap comprising based on weight percentage: TABLE-US-00022 Component A: Zanthoxylum schinifolium nut oil 16.0-20.0%, Propylene glycol 13.0-16.0%, Glycerin 7.0-10.0%; Component B: Deionized water 6.0-8.0%, Sodium alkyl ether sulfate AES 9.0-12.0%; Component C: Lauric acid 6.0-8.0%, Stearic acid 12.0-15.0%; Component D: 98% NaOH 2.5-4.0%, Deionized water balance; and Component E: Zanthoxylum schinifolium essential oil 0.3-2%.

3. The bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap of claim 1 comprising based on weight percentage: TABLE-US-00023 Component A: Zanthoxylum schinifolium nut oil 15.0-21.0%, Propylene glycol 12.0-17.0%, Glycerin 6.0-11.0%; Component B: Deionized water 5.0-8.0%, Sodium alkyl ether sulfate AES 8.0-12.0%; Component C: Lauric acid 5.0-8.0%, Stearic acid 11.0-16.0%; Component D: 98% NaOH 2.5-4.5%, Deionized water balance; and Component E: Zanthoxylum schinifolium essential oil 0.3-0.8%.

4. The bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap of claim 2 comprising based on weight percentage: TABLE-US-00024 Component A: Zanthoxylum schinifolium nut oil 16.0-20.0%, Propylene glycol 13.0-16.0%, Glycerin 7.0-10.0%; Component B: Deionized water 6.0-8.0%, Sodium alkyl ether sulfate AES 9.0-12.0%; Component C: Lauric acid 6.0-8.0%, Stearic acid 12.0-15.0%; Component D: 98% NaOH 2.5-4.0%, Deionized water balance; and Component E: Zanthoxylum schinifolium essential oil 0.3-0.6%.

5. The Zanthoxylum schinifolium skin care soap of claim 1, comprising: Component A: Zanthoxylum schinifolium nut oil 18 wt %, Propylene glycol 13.0 wt %-16.0 wt %, Glycerin 7.0 wt %-10.0 wt %; Component B: Deionized water 6.0 wt %-8.0 wt %, Sodium alkyl ether sulfate AES 9.0 wt-12.0 wt %; Component C: Lauric acid 6.0 wt %-8.0 wt %, Stearic acid 12.0 wt %-15.0 wt %; Component D: 98% NaOH 2.5 wt %-4.0 wt %, Deionized water balance; and Component E: Zanthoxylum schinifolium essential oil 2 wt %, wherein the skincare soap is bactericidal, fungicidal and anti-allergenic.

Description

DETAILED DISCLOSURE

(1) The present invention is further described by the following examples. However, the examples are provided for the purpose of illustration and are not to be construed as limitations of the scope of the invention in any form.

Example 1

(2) Preparation of Zanthoxylum schinifolium Essential Oil

(3) Take 100 grams of Zanthoxylum schinifolium seeds, crush under room temperature, sieve through a 10-mesh screen, and place them in an essential oil extraction equipment, and then add water. The weight ratio between seeds to water is 1:3. Set microwave power at 150 W, extract assisted by microwaves for 1.5 hours; under these conditions, the yield of essential oil is 7.8%. The extracted essential oil is pale yellow and transparent, and has a rich and characteristic Zanthoxylum schinifolium fragrance.

(4) Zanthoxylum schinifolium essential oil obtained above has the following components based on weight percentage:

(5) TABLE-US-00004 Linalool 58.0%, D-lemonene 3.5%, 4-methyl-1-isopropyl-3-cyclohexene-1-ol (terpene alcohol) 2.5%.
Preparation of Zanthoxylum schinifolium Nut Oil

(6) Collect and dry Zanthoxylum schinifolium seeds that have been extracted for essential oil, place them in a Soxhlet extractor for extraction using petroleum ether (30-60 C.) as solvent, heat to reflux, and reflux for 3 hours under a micro-boiling state, recover petroleum ether after extraction by heat to obtain Zanthoxylum schinifolium nut oil. Under these conditions, the yield of nut oil is 21.6%. The extracted nut oil is pale yellow and transparent, and has a rich fragrance.

(7) Zanthoxylum schinifolium nut oil obtained above contains 82.0% of total unsaturated fatty acids based on weight percentage, and the total unsaturated fatty acids contain 28.0% of -linolenic acid based on weight percentage.

(8) The bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap of the present invention comprises the following components based on weight percentage:

(9) TABLE-US-00005 Component A: Zanthoxylum schinifolium nut oil 15.0%, Propylene glycol 12.0%, Glycerin 6.0%, Component B: Deionized water 5.0%, Sodium alkyl ether sulfate AES 8.0%, Component C: Lauric acid 5.0%, Stearic acid 11.0%, Component D: 98% NaOH 2.5%, Deionized water balance, Component E: Zanthoxylum schinifolium essential oil 0.3%.

(10) The method of preparing the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap of the present invention comprises the following steps: (1) add Component A into an emulsifying pot, start agitation, and raise temperature to 50 C., confirm that Component A dissolves homogeneously; (2) add Component B, mix homogeneously, and maintain temperature at 50 C.; (3) add Component C and melt Component C, and maintain temperature at 50 C.; (4) dissolve Component D, and maintain temperature at 50 C.; (5) add Component D, agitate, saponify for 15 minutes, and control the temperature of materials at 75 C.; (6) add Component E, agitate for 10 minutes, and control the temperature of the materials at 75 C.; (7) defoam under vacuum for 15 minutes; confirm the semi-finished product, pour the materials from the emulsifying pot into a mold, and obtain the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap after cooling.

(11) The bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap has a pH of 8.0.

Example 2

(12) Example 2 differs from Example 1 in that:

(13) Take 100 grams of Zanthoxylum schinifolium seeds, crush under room temperature, sieve through a 10-mesh screen, and place them in an essential oil extraction equipment, and then add water. The weight ratio between seeds to water is 1:5. Set microwave power at 250 W, extract assisted by microwaves for 2 hours; under these conditions, the yield of essential oil is 8.2%. The extracted essential oil is pale yellow and transparent, and has a rich and characteristic Zanthoxylum schinifolium fragrance.

(14) Zanthoxylum schinifolium essential oil obtained above has the following components based on weight percentage:

(15) TABLE-US-00006 Linalool 60.0%, D-lemonene 4.5%, 4-methyl-1-isopropyl-3-cyclohexene-1-ol (terpene alcohol) 3.5%.
Preparation of Zanthoxylum schinifolium Nut Oil

(16) Collect and dry Zanthoxylum schinifolium seeds that have been extracted for essential oil, place them in a Soxhlet extractor for extraction using petroleum ether (30-60 C.) as solvent, heat to reflux, and reflux for 3.5 hours under a micro-boiling state, recover petroleum ether after extraction by heat to obtain Zanthoxylum schinifolium nut oil. Under these conditions, the yield of nut oil is 21.9%. The extracted nut oil is pale yellow and transparent, and has a rich fragrance.

(17) Zanthoxylum schinifolium nut oil obtained above contains 85.0% of total unsaturated fatty acids based on weight percentage, and the total unsaturated fatty acids contain 30.0% of -linolenic acid based on weight percentage.

(18) The bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap of the present invention comprises the following components based on weight percentage:

(19) TABLE-US-00007 Component A: Zanthoxylum schinifolium nut oil 17.0%, Propylene glycol 13.5%, Glycerin 7.5%, Component B: Deionized water 6.0%, Sodium alkyl ether sulfate AES 9.5%, Component C: Lauric acid 6.0%, Stearic acid 12.5%, Component D: 98% NaOH 3.0%, Deionized water balance, Component E: Zanthoxylum schinifolium essential oil 0.45%.

(20) The method of preparing the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap of the present invention comprises the following steps: (1) add Component A into an emulsifying pot, start agitation, and raise temperature to 55 C., confirm that Component A dissolves homogeneously; (2) add Component B, mix homogeneously, and maintain temperature at 55 C.; (3) add Component C and melt Component C, and maintain temperature at 55 C.; (4) dissolve Component D, and maintain temperature at 55 C.; (5) add Component D, agitate, saponify for 18 minutes, and control the temperature of materials at 78 C.; (6) add Component E, agitate for 10 minutes, and control the temperature of the materials at 78 C.; (7) defoam under vacuum for 18 minutes; confirm the semi-finished product, pour the materials from the emulsifying pot into a mold, and obtain the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap after cooling.

(21) The bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap has a pH of 8.5.

Example 3

(22) Example 3 differs from Example 1 in that:

(23) Take 100 grams of Zanthoxylum schinifolium seeds, crush under room temperature, sieve through a 10-mesh screen, and place them in an essential oil extraction equipment, and add then water. The weight ratio between seeds to water is 1:6. Set microwave power at 300 W, extract assisted by microwaves for 2.5 hours; under these conditions, the yield of essential oil is 8.6%. The extracted essential oil is pale yellow and transparent, and has a rich and characteristic Zanthoxylum schinifolium fragrance.

(24) Zanthoxylum schinifolium essential oil obtained above has the following components based on weight percentage:

(25) TABLE-US-00008 Linalool 62.0%, D-lemonene 5.5%, 4-methyl-1-isopropyl-3-cyclohexene-1-ol (terpene alcohol) 4.5%.
Preparation of Zanthoxylum schinifolium Nut Oil

(26) Collect and dry Zanthoxylum schinifolium seeds that have been extracted for essential oil, place them in a Soxhlet extractor for extraction using petroleum ether (30-60 C.) as solvent, heat to reflux, and reflux for 4 hours under micro-boiling state, recover petroleum ether after extraction by heat to obtain Zanthoxylum schinifolium nut oil. Under these conditions, the yield of nut oil is 22.3%. The extracted nut oil is pale yellow and transparent, and has a rich fragrance.

(27) Zanthoxylum schinifolium nut oil obtained above contains 88.0% of total unsaturated fatty acids based on weight percentage, and the total unsaturated fatty acids contain 31.0% of -linolenic acid based on weight percentage.

(28) The bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap of the present invention comprises the following components based on weight percentage:

(29) TABLE-US-00009 Component A: Zanthoxylum schinifolium nut oil 19.0%, Propylene glycol 15.5%, Glycerin 9.0%, Component B: Deionized water 7.0%, Sodium alkyl ether sulfate AES 10.5%, Component C: Lauric acid 7.0%, Stearic acid 14.0%, Component D: 98% NaOH 4.0%, Deionized water balance, Component E: Zanthoxylum schinifolium essential oil 0.6%.

(30) The method of preparing the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap of the present invention comprises the following steps: (1) add Zanthoxylum schinifolium nut oil, propylene glycol, and glycerin of Component A into an emulsifying pot, start agitation, raise temperature to 58 C., and dissolve Component A homogeneously; (2) add deionized water and sodium alkyl ether sulfate AES of Component B, mix homogeneously, and maintain temperature at 58 C.; (3) add lauric acid and stearic acid of Component C into the emulsifying pot to melt, and maintain temperature at 58 C.; (4) dissolve 98% NaOH in water of Component D, and maintain temperature at 58 C.; (5) add Component D, agitate, saponify for 22 minutes, and control the temperature of materials at 82 C.; (6) add Zanthoxylum schinifolium essential oil of Component E, agitate for 10 minutes, and control the temperature of the materials at 82 C.; (7) defoam under vacuum for 22 minutes; confirm the semi-finished product, pour the materials from the emulsifying pot into a mold, and obtain the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap after cooling.

(31) The bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap has a pH of 9.0

Example 4

(32) Example 4 differs from Example 1 in that:

(33) Take 100 grams of Zanthoxylum schinifolium seeds, crush under room temperature, sieve through a 10-mesh screen, and place them in an essential oil extraction equipment, and add water. The weight ratio between seeds to water is 1:8. Set microwave power at 350 W, extract assisted by microwaves for 3 hours; under these conditions, the yield of essential oil is 8.9%. The extracted essential oil is pale yellow and transparent, and has a rich and characteristic Zanthoxylum schinifolium fragrance.

(34) Zanthoxylum schinifolium essential oil obtained above has the following components based on weight percentage:

(35) TABLE-US-00010 Linalool 65.0%, D-lemonene 6.5%, 4-methyl-1-isopropyl-3-cyclohexene-1-ol (terpene alcohol) 5.5%.
Preparation of Zanthoxylum schinifolium Nut Oil

(36) Collect and dry Zanthoxylum schinifolium seeds that have been extracted for essential oil, place them in a Soxhlet extractor for extraction using petroleum ether (30-60 C.) as solvent, heat to reflux, and reflux for 5 hours under micro-boiling state, recover petroleum ether after extraction by heat to obtain Zanthoxylum schinifolium nut oil. Under these conditions, the yield of nut oil is 22.7%. The extracted nut oil is pale yellow and transparent, and has a rich fragrance.

(37) Zanthoxylum schinifolium nut oil obtained above contains 92.0% of total unsaturated fatty acids based on weight percentage, and the total unsaturated fatty acids contain 33.0% of -linolenic acid based on weight percentage.

(38) The bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap of the present invention comprises the following components based on weight percentage:

(39) TABLE-US-00011 Component A: Zanthoxylum schinifolium nut oil 21.0%, Propylene glycol 17.0%, Glycerin 11.0%, Component B: Deionized water 8.0%, Sodium alkyl ether sulfate AES 12.0%, Component C: Lauric acid 8.0%, Stearic acid 16.0%, Component D: 98% NaOH 4.5%, Deionized water balance, Component E: Zanthoxylum schinifolium essential oil 0.8%.

(40) The method of preparing the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap of the present invention comprises the following steps: (1) add Zanthoxylum schinifolium nut oil, propylene glycol, and glycerin of Component A into an emulsifying pot, start agitation, raise temperature to 62 C., and dissolve Component A homogeneously; (2) add deionized water and sodium alkyl ether sulfate AES of Component B, mix homogeneously, and maintain temperature at 62 C.; (3) add lauric acid and stearic acid of Component C into the emulsifying pot to melt, and maintain temperature at 62 C.; (4) dissolve 98% NaOH in water of Component D, and maintain temperature at 62 C.; (5) add Component D, agitate, saponify for 25 minutes, and control the temperature of the materials at 85 C.; (6) add Zanthoxylum schinifolium essential oil of Component E, agitate for 10 minutes, and control the temperature of the materials at 85 C.; (7) defoam under vacuum for 25 minutes; confirm the semi-finished product, pour the materials from the emulsifying pot into a mold, and obtain the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap after cooling.

(41) The bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soap has a pH of 9.5

(42) Experiment 1

(43) The bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soaps prepared in Example 1 to Example 4 have the following physical and chemical indicators:

(44) Physical State

(45) The skin care soap has good stability, characteristic Zanthoxylum schinifolium fragrance, and exquisite uniform pale yellow color, and is translucent.

(46) pH Value

(47) Take the skin care soaps prepared in Example 1 to Example 4, wet them with distilled water, and test them with pH papers. The pH values range between 7.5-10.0.

(48) Skin Irritation and Allergic Reaction Tests

(49) Take 12 experimental mice, remove the hair on the back of each mouse by rosin hot-melt method, apply the soaps prepared in Example 1 to Example 4 that have wetted by distilled water to the bare skin, observe 1 hour after the application, and compare the treated skin with untreated skin. The results showed the skin care soaps did not cause irritation or allergic reaction.

(50) Apply the skin care soaps prepared in Example 1 to Example 4 that have been wetted by distilled water to the back of the hands of volunteers (12-60 years old, 58 volunteers), observe 30 minutes after the application. No skin redness, itching, blistering, or rash were observed.

(51) Experiment 2

(52) Bactericidal and Fungicidal Effects of Zanthoxylum schinifolium Skin Care Soaps Prepared in Example 1 to Example 4

(53) Materials and Method

(54) Material

(55) Test sample: Zanthoxylum schinifolium skin care soap prepared in Example 1 to Example 4.

(56) Test strain: Fungi: Candida albicans C. albicans (SC5314). Bacteria: Pseudomonas aeruginosa(PA14).

(57) Medium: yeast extract peptone glucose (YPD) agar medium.

(58) Preparation of bacterium and fungus suspensions: bacterial or fungal suspension was prepared by agar plate method, and the test bacterium or fungus was activated on the slant medium for two generations. Then, the bacterium or fungus rings were scraped from the slant surface with tweezers, and were collected in triangular flasks containing different volumes of sterile physiological saline, respectively. The suspension of Candida albicans was prepared with the final concentration of 110.sup.4 CFU/mL, and the suspension of Pseudomonas aeruginosa was prepared with the final concentration of 110.sup.8 CFU/mL.

(59) Determination of Bactericidal and Fungicidal Activity

(60) Mix the soap samples and bacterium or fungus suspension in a 96-well plate, set aside for 1 minute, draw 10 L suspension, drop on the YPD solid medium, and culture for 24 hours, count the number of colonies and repeat three times.

(61) The results of fungicidal activity against the Candida albicans of Zanthoxylum schinifolium skin care soaps prepared in Example 1 to Example 4 are shown in Table 1, Table 2, Table 3 and Table 4, respectively; and the results of bactericidal activity against Pseudomonas aeruginosa of the Zanthoxylum schinifolium skin care soaps prepared in Example 1 to Example 4 are shown in Table 5, Table 6, Table 7 and Table 8, respectively.

(62) The results of the fungicidal test on Candida albicans by the Zanthoxylum schinifolium skin care soap prepared in Example 1 for 1 minute are shown in Table 1; the results of fungicidal test on Candida albicans by the Zanthoxylum schinifolium skin care soap prepared in Example 2 for 1 minute are shown in Table 2; the results of fungicidal test on Candida albicans by the Zanthoxylum schinifolium skin care soap prepared in Example 3 for 1 minute are shown in Table 3; and the results of fungicidal test on Candida albicans by the Zanthoxylum schinifolium skin care soap prepared in Example 4 for 1 minute are shown in Table 4. The results of the bactericidal test on Pseudomonas aeruginosa by the Zanthoxylum schinifolium skin care soap prepared in Example 1 for 1 minute are shown in Table 5; the results of bactericidal test on Pseudomonas aeruginosa by the Zanthoxylum schinifolium skin care soap prepared in Example 2 for 1 minute are shown in Table 6; the results of bactericidal test on Pseudomonas aeruginosa by the Zanthoxylum schinifolium skin care soap prepared in Example 3 for 1 minute are shown in Table 7; and the results of bactericidal test on Pseudomonas aeruginosa by the Zanthoxylum schinifolium skin care soap prepared in Example 4 for 1 minute are shown in Table 8.

(63) TABLE-US-00012 TABLE 1 Sample Dilution Factor 1/16 1/32 1/64 Repeat 1 0 >20 >20 >20 >20 >20 Repeat 2 0 >20 >20 >20 >20 >20 Repeat 3 0 >20 >20 >20 >20 >20

(64) TABLE-US-00013 TABLE 2 Sample Dilution Factor 1/16 1/32 1/64 Repeat 1 0 >20 >20 >20 >20 >20 Repeat 2 0 >20 >20 >20 >20 >20 Repeat 3 0 >20 >20 >20 >20 >20

(65) TABLE-US-00014 TABLE 3 Sample Dilution Factor 1/16 1/32 1/64 Repeat 1 0 >20 >20 >20 >20 >20 Repeat 2 0 >20 >20 >20 >20 >20 Repeat 3 0 >20 >20 >20 >20 >20

(66) TABLE-US-00015 TABLE 4 Sample Dilution Factor 1/16 1/32 1/64 Repeat 1 0 >20 >20 >20 >20 >20 Repeat 2 0 >20 >20 >20 >20 >20 Repeat 3 0 >20 >20 >20 >20 >20

(67) TABLE-US-00016 TABLE 5 Sample Dilution Factor 1/16 1/32 1/64 Repeat 1 0 12 >20 >20 >20 >20 Repeat 2 0 9 >20 >20 >20 >20 Repeat 3 0 11 >20 >20 >20 >20

(68) TABLE-US-00017 TABLE 6 Sample Dilution Factor 1/16 1/32 1/64 Repeat 1 0 11 >20 >20 >20 >20 Repeat 2 0 7 >20 >20 >20 >20 Repeat 3 0 15 >20 >20 >20 >20

(69) TABLE-US-00018 TABLE 7 Sample Dilution Factor 1/16 1/32 1/64 Repeat 1 0 8 >20 >20 >20 >20 Repeat 2 0 8 >20 >20 >20 >20 Repeat 3 0 12 >20 >20 >20 >20

(70) TABLE-US-00019 TABLE 8 Sample Dilution Factor 1/16 1/32 1/64 Repeat 1 0 10 >20 >20 >20 >20 Repeat 2 0 12 >20 >20 >20 >20 Repeat 3 0 9 >20 >20 >20 >20

(71) This experiment selected Candida albicans as a representative fungus that is harmful to the human body, and Pseudomonas aeruginosa as a representative bacterium that is harmful to the human body. The rapid killing effect of the Zanthoxylum schinifolium skin care soap prepared in Example 1 to Example 4 on these two pathogens was examined.

(72) The results showed that the Zanthoxylum schinifolium skin care soaps prepared in Example 1 to Example 4 had prominent killing effect on Candida albicans and Pseudomonas aeruginosa, and the sterilization rate reached 100% in 1 minute, and the soaps had very excellent bactericidal and fungicidal effect.

(73) Experiment 3

(74) Evaluation of the Effectiveness of the Zanthoxylum schinifolium Skin Care Soaps

(75) Zanthoxylum schinifolium skin care soaps prepared in Example 1 to Example 4 were evaluated using consumer surveys. 56 subjects aged 18-55 years old were selected as trial subjects, and were randomly divided into 4 trial groups. The Zanthoxylum schinifolium skin care soaps prepared in Example 1 to Example 4 were tried in each group. The usage requirements were three times a day for the morning, evening and evening cleansing for 6 weeks. The highest score was 10: 10 points means very satisfactory and very effective; 8 points means satisfactory and effective; 6 points means acceptable and generally effective; and less than 6 points means unacceptable and not effective. The tabulated effects of the Zanthoxylum schinifolium skin care soaps, in average score, are shown in Table 9:

(76) TABLE-US-00020 TABLE 9 Example 1 Example 2 Example 3 Example 4 Average Average Average Average Tabulated Effectiveness score score score score score Cleansing 10 10 10 10 10 Capacity Foaming 9.8 9.9 9.7 9.5 9.7 Ability Moisturizing 9.2 9.4 9.4 9.3 9.3 Ability Nourishing 8.8 9.0 9.2 9.1 9.0 Ability

(77) As shown in Table 9, the bactericidal, fungicidal and anti-allergenic Zanthoxylum schinifolium skin care soaps of the present invention have a high foaming ability, have a high cleaning capacity, have an excellent ability of moisturizing and nourishing skin, and also have an excellent bactericidal and fungicidal effect.

(78) The basic principles, principal features and advantages of the present invention have been shown and described. It should be understood by those skilled in the art that the present invention is not limited to the embodiments described above and that the foregoing embodiments and description are intended to be illustrative of the principles of the invention. Various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims, the description and the equivalents thereof.