Compositions and Methods for Treating Anhidrosis

Abstract

Provided herein are compositions and methods useful for the treatment of anhidrosis in mammals, for example, horses.

Claims

1. A horse feed composition or additive comprising a substantial amount of a nitric oxide enhancer for the treatment or prevention of anhidrosis in mammals.

2. The horse feed composition or additive of claim 1 wherein said nitric oxide enhancer is L-arginine.

3. The horse feed composition or additive of claim 1 wherein said nitric oxide enhancer is L-arginine in an amount of 20-35%.

4. The horse feed composition or additive of 1 wherein said nitric oxide enhancer is L-arginine in an amount of about 23%.

5. The horse feed composition or additive of claim 1 further comprising an antioxidant.

6. The horse feed composition or additive of claim 5 wherein said antioxidant is selected from the group consisting of vitamin A, vitamin C, vitamin E, beta-carotene and combinations thereof.

7. The horse feed composition or additive of claim 1 further comprising an electrolyte.

8. The horse feed composition or additive of claim 7 wherein said electrolyte is selected from time group consisting of potassium, sodium, magnesium, calcium, chloride, phosphorus, sulfate, carbonate, citrate and combinations thereof.

9. The horse feed composition or additive of claim 7 wherein said electrolyte is a combination of sodium chloride and potassium chloride.

10. The horse feed composition or additive of claim 1 further comprising an omega 3 fatty acid.

11. The horse feed composition or additive of claim 10 wherein said omega 3 fatty acid is selected from the group consisting of -linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and combinations thereof.

12. The horse feed composition or additive of claim 1 further comprising L-tyrosine.

13. The horse feed composition or additive of claim 1 that comprises about 30.5% potassium chloride, about 24.5% sodium chloride, about 23% L-arginine, about 12.2% vitamin C, about 2.4% vitamin E 360, about 3.5% L-tyrosine, about 1.8% choline bitartrate, about 0.8% vitamin 95, about 0.5% vitamin 93, about 0,5% vitamin B6, about 0.1% vitamin B1 and about 0.02% folic acid.

14. A method of treating or preventing anhidrosis comprising the step of administering at least about 8000 mg/day L-arginine to a mammal in need thereof.

15. The method of claim 14 that comprises administering between about 8000 mg/day and 18,000 mg/day L-arginine to a mammal in need thereof.

16. The method of claim 5 wherein said mammal is a horse.

17. A method of treating or preventing anhidrosis comprising the step of administering the feed composition or additive of claim 1 to a mammal in need thereof.

18. The method of claim 17 wherein said mammal is a horse.

19. A method of treating or preventing anhidrosis comprising the step of administering the feed composition or additive of claim 13 to a mammal in need thereof.

20. The method of claim 19 wherein said mammal is a horse.

Description

EXAMPLES

[0025] As used herein, the symbols and conventions used in these processes, schemes and examples, regardless of whether a particular abbreviation is specifically defined, are consistent with those used in the contemporary scientific literature.

Example 1

[0026] An embodiment is the following composition formulated for oral administration to a horse twice a day.

TABLE-US-00001 TABLE 1 Label Formula Claim per Serving per Serving Ingredient (mg) (mg) Percent Potassium Chloride 6250.00 6250.00 30.49% NaCl 5000.00 5000.00 24.39% L-Arginine 4750.00 4750.00 23.17% Vitamin C 2500.00 2500.00 12.20% Vitamin E 630 500.00 500.00 2.44% L-Tyrosine 720.00 720.00 3.51% Choline Bitartrate 375.00 375.00 1.83% Vitamin B5-Calcium Pantothenate 175.00 175.00 0.85% Vitamin B3-Niacin 100.00 100.00 0.49% Vitamin B6-Pyridoxine HCl 100.00 100.00 0.49% Vitamin B1-Thiamin 25.00 25.00 0.12% Folic Acid 5.00 5.00 0.02% Totals 20,500.00 20,500.00 100.00%

Example 2

[0027] Horses with anhidrosis were treated with the formulation provided in Example 1 twice per day (Table 2).

TABLE-US-00002 TABLE 2 Stopped Sweating Sweating Horse Sweating at 1 month at 2 months 1 Chronic No No 2 Yes 3 Jun. 20, 2011 No Yes 4 Jun. 1, 2011 No Better but not 100% 5 Jun. 5, 2011 No Better but not 100% 6 May 2011 No 7 May 2011 No 8 May 2011 No 9 May 2011 No 10 May 2011 No 11 2008 Yes 12 May 2011 Yes 13 May 2011 No No 14 2006 Yes No 15 Summer 2010 No

[0028] Out of 15 horses administered the composition described in Example 1, four (4) horses resumed sweating by at least one month after administration started. At two months, another horse was fully sweating again, and two horses showed improved, but not complete sweating. Overall, administration of the composition of Example 1 restored or improved the sweating in 7 of 15 horses.

Example 3

[0029] An embodiment is the following composition formulated for oral administration to a horse twice a day.

TABLE-US-00003 TABLE 3 Label Claim Formula per Serving Ingredients Percent (mg) (mg) L-Arginine 34.01% 7617.963 7500.0 Potassium Chloride 27.96% 6262.525 6250.0 NaCl 22.51% 5041.575 5000.0 Vitamin C 6.19% 1387.626 1250.0 L-Tyrosine 3.28% 734.473 720.0 Vitamin E 630 2.25% 505.000 500.0 Choline Bitartrate 1.77% 397.538 375.0 Vitamin B5-Calcium Pantothenate 0.88% 196.071 175.0 Vitamin B3-Niacin 0.50% 111.523 100.0 Vitamin B6-Pyridoxine HCl 0.50% 112.041 100.0 Vitamin B1-Thiamin 0.13% 28.010 25.0 Folic Acid 0.03% 5.655 5.0 Totals 100.00% 22,400.000 22,000.0

Example 4

[0030] The embodiment of the compositions provided in Example 3 was administered to horses having one or more symptoms of anhidrosis. As detailed in the following table, some of the horses had no prior treatments for anhidrosis, and some of the horses had one or more than one prior treatments for anhidrosis. The results of the administrations are summarized in Table 4. These results were reported by voluntarily by individuals that had administered the composition and observed the results.

TABLE-US-00004 TABLE 4 Results from Results from Treatment Treatment Condition Prior Prior with with Horse Condition Duration Treatment Treatment Example 3 Example 3 1 Anhidrosis 10 days Sweating 2 Poor Yes Sweating sweating better 3 Poor One AC, Leg Some Yes Sweating sweating Magic improvement, short duration 4 Non- ProSweat, No Success 3 wks. Sweating sweater Make Em Sweat, One AC 5 Non- Chronic Yes Sweating sweater better than ever 6 2 wks Marked improvement 7 One AC, Minimal Yes Better True Sweat success sweatinclt, 8 Anhidrosis 4-5 mos. None 4-5 months 3-4 wks. Results seen anhidrosis 9 Anhidrosis 1 yr. One AC Anhidrosis 1 Yes Sweating, year respiration improved 10 Anhidrosis 4 yrs. One AC 3 months 2 wks. Results seen some sweating 11 Anhidrosis 10 yrs. One AC No success 1 wk. Results seen 12 Anhidrosis 6 yrs. One AC Success Immediate Success 13 Anhidrosis 1 yr. 2 One AC, No 2-3 wks. Results mos. acupuncture, observed Sweat Activator 14 Anhidrosis 3 yrs. One AC Some 1 wk. Results observed 15 Anhidrosis Year- One AC, No 1 mo. Results round acupuncture, herbs 16 Anhidrosis 2 yrs. One AC 3 months, no 45 days Results 17 Anhidrosis 1 yr. One AC 3 months, Yes Success minimal success 18 Anhidrosis 5 mos. Acupuncture 1-3 months, One mo. Response no success 19 Anhidrosis Summers One AC 3 months, no Yes Sweating success 20 Anhidrosis 3 One AC 1-3 months, Yes Sweating summers success first normally summer only, no success subsequent summers 21 Anhidrosis, 2 mos. One AC, No success 4 wks. Sweating two electrolytes months 22 Yes Success 23 One AC, Let No success Yes Sweating Em Sweat, Salt, Beer 24 5 days Sweating 25 Anhidrosis 1 yr. Acupuncture, Little or no 23 days Sweating herbs, One sweating AC, beer, True Sweat 26 Anhidrosis 1 mo. 1 mo. Sweating 27 1 yr. True Sweat No sweating 2 days Sweating, behind saddle back and hindquarters 28 Anhidrosis Chronic 7 days Sweating

[0031] All publications and patent, applications cited in this specification are herein incorporated by reference as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. While the claimed subject matter has been described in terms of various embodiments, the skilled artisan will appreciate that various modifications, substitutions, omissions, and changes may be made without departing from the spirit thereof. Accordingly, it is intended that the scope of the subject matter limited solely by the scope of the following claims, including equivalents thereof.